immunization with the r4D Ag alters the course of experimental syphilis in a manner consistent with previously defined parameters of partial protection. (Borenstein et al., 1988)
The reactivities of TpF1 with syphilitic sera were proportional to the titers of the T. pallidum particle agglutination (TPPA) assay. These data indicate that the recombinant protein TpF1 is a highly immunogenic protein in human and rabbit infections and a promising marker for the screening of syphilis.(Jiang et al., 2013)
References
Borenstein et al., 1988: Borenstein LA, Radolf JD, Fehniger TE, Blanco DR, Miller JN, Lovett MA. Immunization of rabbits with recombinant Treponema pallidum surface antigen 4D alters the course of experimental syphilis. Journal of immunology (Baltimore, Md. : 1950). 1988; 140(7); 2415-2421. [PubMed: 2450921].
Jiang et al., 2013: Jiang C, Zhao F, Xiao J, Zeng T, Yu J, Ma X, Wu H, Wu Y. Evaluation of the recombinant protein TpF1 of Treponema pallidum for serodiagnosis of syphilis. Clinical and vaccine immunology : CVI. 2013; 20(10); 1563-1568. [PubMed: 23945159].
Gene Information
Gene Name
tpf1
Protein Information
Protein Name
DNA starvation/stationary phase protection protein
