VIOLIN: Vaccine Investigation and Online Information Network

cpn60

General Information

Protegen ID

382

Sequence Strain (Species/Organism)

Bordetella pertussis

VO ID

VO_0011035

Taxonomy ID

520

Other Database IDs

CDD:234573
CDD:239460

Molecule Role

Protective antigen

Molecule Role Annotation

A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73 kDa N-terminal alpha-domain of BrkA autotransporter protein and the Cpn60/60 kDa chaperonin. Both stimulated antibodies against pertussis and induced a 42% protection rate against the challenge (Cainelli et al., 2007).

Related Vaccines(s)

B. pertussis Cpn60 protein vaccine

References

Cainelli et al., 2007: Cainelli Gebara VC, RisolÃ©o L, Lopes AP, Ferreira VR, Quintilio W, LÃ©pine F, Silva WD, Raw I. Adjuvant and immunogenic activities of the 73kDa N-terminal alpha-domain of BrkA autotransporter and Cpn60/60kDa chaperonin of Bordetella pertussis. Vaccine. 2007; 25(4); 621-629. [PubMed: 17011680].

Gene Information

Gene Name

cpn60

Protein Information

Protein Name

Cpn60 (GroEL)

NCBI Protein GI

968920

Protein pI

4.81

Protein Weight

52145.9

Protein Length

605

Protein Note

chaperonin GroEL; Reviewed; PRK00013

Protein Sequence

>AAA74967.1 Cpn60 (GroEL) [Bordetella pertussis]
MAAKQVLFADEARVRIVRGVNVLANAVKTTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENIG
AQLVKDVASKTSDNAGDGTTTATVLAQAVVQEGLKYVAAGFNPIDLKRGIDKAVAAAVEELKKLSKPVTT
SKEIAQVGSISANSDASIGQIIADAMDKVGKEGVITVEDGKSLENELDVVEGMQFDRGYLSPYFINSPEK
QVAALDDPYVLIYDKKVSNIRDLLPVLEQVAKSSRPLLIIAEDVEGEALATLVVNNIRGILKTTAVKAPG
FGDRRKAMLEDIAILTGGTVISEETGMSLEKATLQDLGQAKRIEVAKENTTIIDGAGDGKSIEARVKQIR
AQIEEATSDYDREKLQERVAKLAGGVAVIRVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALL
RAKQAITGLKGDTADQNAGIKLILRAVEEPLRTIVTNAGDEASVVVNTVLNGKGNYGYNAATGEYGDLVE
QGVLDPTKVTRTALQNAASVASLLLTAEAAVVELMENKPAAAPAMPGGMGGMGGMDF

Epitope Information

IEDB Linear Epitope