VIOLIN: Vaccine Investigation and Online Information Network

YPO0612

General Information

Protegen ID

344

Sequence Strain (Species/Organism)

Yersinia pestis CO92

VO ID

VO_0011007

Taxonomy ID

214092

Molecule Role

Protective antigen

Molecule Role Annotation

Using a mouse plague model, YPO0612 may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).

References

Li et al., 2009: Li B, Zhou L, Guo J, Wang X, Ni B, Ke Y, Zhu Z, Guo Z, Yang R. High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay. Infection and immunity. 2009; 77(10); 4356-4361. [PubMed: 19651863].

Gene Information

Gene Name

YPO0612

NCBI Gene ID

1173455

Genbank Accession

CP009973

Locus Tag

YPO0612

Gene Starting Position

672594

Gene Ending Position

673838

DNA Sequence

>NC_003143.1:672594-673838 Yersinia pestis CO92 chromosome, complete genome
TATGAAGATACTTTATTATATTGCCATCGCGATAGCCTCGCTGCCGCTTATGGCGGCCGAAAGGCTAGAA
ATTATGGTGCCCAGCGGCAGCTATGTTTCTTTTATGCGTAATACCGTCACCCCTGAATTTAATAAGCTCT
ATCCCGAGGTTAATTTAGTGGTATCCAATGACGAACAACTGGATACCCGAATGGCCGCCGGGGATAACCC
CAATGTTTACATCGGTGTATTCGGCTATCAACCCGCCAAACTGGCGAAGCTTGGCAAGCTGGCGTATTTG
GATAAATTCCCCGGTTTTGCCGAATTAAATGAACGTATCGATCCTCACTTCTTACGCGAAAACTTTGGCC
GTACCTATTATATTCCGTGGAACGCCACCACCCAGATGATGATTTATAATAAGGAGCTATTTGCTGAGGC
AGGCTTGGATCCTGAGCGCCCTCCAGCGACCTGGGATGAATTTTTACTGGCGGCCGAAAAGATCTCCGCC
TTGCCCCCTCGCTCAGACGGTAGCAAAGTCTACGGCACGGTATTCTGGAATGATGTGCTGTCATTCGGCA
GTTGGTACTGGAATCTGCTGGCACCCATGTATTACAACGTTAATCAGGGCCAGTATCAGTTGCTAAACCG
CTACGGTACCGACATCGTATTCGACCGTCCCGACGCCAACATGGCGCAGTTTATGCGTACCATGCAGCAG
GCGCAGCGCTTTGCGCCACTGACCATGGAAAAAAGCTTCTTCTCCCGTAATATCGGCATGTGGCTACAAT
TCGGCTTCGGCTGGAAGGCCACCCTCTCGTCGGCGGCTGAACGCCCAATGGTGGTAGGCCAGGACGTGGC
CATCGCCCCGATCCCGGTACAAACCAAGGGCGACATCCACTACTCGGTATTGGATGGTCGGGCCATCATG
ATTTTCAAGGATGAGGCCAGGAAAGAGCAACTCAGTTGGGCGCTGCTCAACCTACTTATGCGCGACGATA
TCAATCTACAGGCCAATATTGCCCTGGGTCAGCTCCCTACGTTGAAGGCGCTGCAAGATGCTCCCTATTT
TCAGTCCGCAGAGGCACAGCCGTTCGTACAGCAACTACAACATGCGATCCTGAGTGAGCCTTTCGCCAAT
GCGATGGAGGTGGCGAATATTATTCTCGCCAACTACAGCAAAGTGGTACTGAAAGGGGAAATATCCCCGG
AACAAGCGGTTGCCACCTCGGCACAGGCCGCACGCCAACTGCTCAATGAACACTG

Protein Information

Protein Name

sugar binding protein

NCBI Protein GI

218927806

Protein Accession

YP_002345681

Protein pI

5.11

Protein Weight

44490.69

Protein Length

414

Protein Note

Similar to Rhizobium meliloti putative trehalose/maltose binding protein ThuE TR:Q9R9Q7 (EMBL: AF175299) (423 aa) fasta scores: E(): 1.4e-08, 23.9% id in 427 aa, and to Thermotoga maritima hypothetical protein TM1120 TR:Q9X0K4 (EMBL: AE001770) (436 aa) fasta scores: E(): 5.9e-09, 22.3% id in 452 aa

Protein Sequence

>YP_002345681.1 sugar binding protein [Yersinia pestis CO92]
MKILYYIAIAIASLPLMAAERLEIMVPSGSYVSFMRNTVTPEFNKLYPEVNLVVSNDEQLDTRMAAGDNP
NVYIGVFGYQPAKLAKLGKLAYLDKFPGFAELNERIDPHFLRENFGRTYYIPWNATTQMMIYNKELFAEA
GLDPERPPATWDEFLLAAEKISALPPRSDGSKVYGTVFWNDVLSFGSWYWNLLAPMYYNVNQGQYQLLNR
YGTDIVFDRPDANMAQFMRTMQQAQRFAPLTMEKSFFSRNIGMWLQFGFGWKATLSSAAERPMVVGQDVA
IAPIPVQTKGDIHYSVLDGRAIMIFKDEARKEQLSWALLNLLMRDDINLQANIALGQLPTLKALQDAPYF
QSAEAQPFVQQLQHAILSEPFANAMEVANIILANYSKVVLKGEISPEQAVATSAQAARQLLNEH

Epitope Information

IEDB Linear Epitope