VIOLIN: Vaccine Investigation and Online Information Network

YPMT1.84 (F1 capsule antigen)

General Information

Protegen ID

341

Sequence Strain (Species/Organism)

Yersinia pestis CO92

VO ID

VO_0011004

Taxonomy ID

214092

Molecule Role

Protective antigen

Molecule Role Annotation

Intranasal immunization with flagellin and the F1 antigen was protective against intranasal challenge with virulent Y. pestis CO92, with 93 to 100% survival of immunized mice. Lastly, vaccination of cynomolgus monkeys with flagellin and a fusion of the F1 and V antigens of Y. pestis induced a robust antigen-specific IgG antibody response (Honko et al., 2006).

Related Vaccines(s)

Y. pestis F1 antigen Vaccine with Flagellin

References

Honko et al., 2006: Honko AN, Sriranganathan N, Lees CJ, Mizel SB. Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infection and immunity. 2006; 74(2); 1113-1120. [PubMed: 16428759].

Gene Information

Gene Name

YPMT1.84 (F1 capsule antigen)

NCBI Gene ID

1172839

Genbank Accession

AL117211

Locus Tag

YPMT1.84

Plasmid No

pMT1

Gene Starting Position

85949

Gene Ending Position

86461

DNA Sequence

>NC_003134.1:85949-86461 Yersinia pestis CO92 plasmid pMT1, complete sequence
TATGAAAAAAATCAGTTCCGTTATCGCCATTGCATTATTTGGAACTATTGCAACTGCTAATGCGGCAGAT
TTAACTGCAAGCACCACTGCAACGGCAACTCTTGTTGAACCAGCCCGCATCACTCTTACATATAAGGAAG
GCGCTCCAATTACAATTATGGACAATGGAAACATCGATACAGAATTACTTGTTGGTACGCTTACTCTTGG
CGGCTATAAAACAGGAACCACTAGCACATCTGTTAACTTTACAGATGCCGCGGGTGATCCCATGTACTTA
ACATTTACTTCTCAGGATGGAAATAACCACCAATTCACTACAAAAGTGATTGGCAAGGATTCTAGAGATT
TTGATATCTCTCCTAAGGTAAACGGTGAGAACCTTGTGGGGGATGACGTCGTCTTGGCTACGGGCAGCCA
GGATTTCTTTGTTCGCTCAATTGGTTCCAAAGGCGGTAAACTTGCAGCAGGTAAATACACTGATGCTGTA
ACCGTAACCGTATCTAACCAATA

Protein Information

Protein Name

F1 capsule antigen

NCBI Protein GI

16082876

Protein Accession

NP_395430

Protein pI

4.63

Protein Weight

16375.93

Protein Length

170

Protein Sequence

>NP_395430.1 F1 capsule antigen (plasmid) [Yersinia pestis CO92]
MKKISSVIAIALFGTIATANAADLTASTTATATLVEPARITLTYKEGAPITIMDNGNIDTELLVGTLTLG
GYKTGTTSTSVNFTDAAGDPMYLTFTSQDGNNHQFTTKVIGKDSRDFDISPKVNGENLVGDDVVLATGSQ
DFFVRSIGSKGGKLAAGKYTDAVTVTVSNQ

Epitope Information

IEDB Linear Epitope