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Fasl

General Information
Protegen ID 302
Sequence Strain (Species/Organism) Mus musculus
Taxonomy ID 10090
Molecule Role Protective antigen
Molecule Role Annotation Introduction of CD95L (Fasl) cDNA into murine tumor cells did not affect growth in vitro but caused rejection in vivo. Neutrophils were primarily responsible for this rejection. A CD8 T cell-mediated protective immunity against subsequent challenge with parental tumor cells was also elicited (Seino et al., 1997).
References
Seino et al., 1997: Seino K, Kayagaki N, Okumura K, Yagita H. Antitumor effect of locally produced CD95 ligand. Nature medicine. 1997; 3(2); 165-170. [PubMed: 9018234].
Gene Information
Gene Name Fasl
NCBI Gene ID 14103
Genbank Accession AC164414
Chromosome No 1
Gene Starting Position 161780690
Gene Ending Position 161788494
DNA Sequence 
>NC_000067.6:161780690-161788494 Mus musculus strain C57BL/6J chromosome 1, GRCm38.p4 C57BL/6J
ATTTCCAAAGTCTATGTCCTTAAGGCATTTCTGTATTCTATAACATAATTTTATTTGTCTTTTCCTCATT
AGGATGTTCAGAGCATAAATACTAGTTGTATTAAAGAAAAACAGCATCAGTAGCTGATAATAAAAGATTT
TGAAGACTATTAGAGTTTATTGCCAAGAAACATTCAGATATCTAGCATCAAATGTAACAGGTTTCTAATA
TGTACTCCATAATGTACATATTTTATTTATATGACTCCTTAGAATCTGTTTGCTCTCATACATACAAACA
CACAGACATCATTGCACTGGAGGTATGCATGCTATGTAGAGAATGATTTGTGCCTCAAACATCCCTCTTA
CTTCTCCGTTAGGATCAAAGGTCGGCTCAGAAAACATTAGGTAACAGTAAAGATGGTGCCAATGAGACAC
TGTCTTTTTTTCAGTCTCTAGCTTATCAGTCAAATGAGCCTCCTTTCTCACCCTTGTATATTCATACCAC
AACTATGTCTCAAAAACGGCCTCTGTGAGGTAGTAAGTAGACCCACCCTGGAAGTGAGTGTAAAGGTGTC
TTCTTCAATGGTTAAAATTCTCTTGGCCATTTAACATCAGACAGTTCTTTCTCTGTGCCTCTGCATTGTC
ACACAGCAGCCCAAAGCTTTATGTCCCTCAGTCACAGACCTCCTTCCATCTGGCTCATGATGCAGGCATT
AAGGACCACTCCATGGACCTCGAGAAAATGAAGGATAGCTGACCTGTTGGACCTTGCGGTCATGAGGTCT
TTGTGGCTCATGTAGTCTTAATTAATCTCAATAGGTCTTAAGAAGACTCTCATTCAAGACAATATTCCTG
GTGCCCATGATAAAGAATAGTAGATCATTTTAAAATGCTTTTTCTTTTAAAGCTTATACAAGCCGAAAAA
GGTCTTAGATTCCTCAAAATTGATCAGAGAGAGTTGAGATATGTTGACATATAAATGGTCAGCACTGGTA
AGATTGAATACTGCCCCCAGGTAGCTGCTGTGGGCCCATATCTGTCCAGTAGTGCAGTAGTTCAACCTCT
TCTCCTCCATTAGCACCAGATCCTCAGGATACTTAGAGTTCCTCATATAGACCTTGTGGTTTAGGGGCTG
GTTGTTGCAAGACTGACCCCGGAAGTATACTTTGGAATACACGAAGTACAACCCAGTTTCGTTGATCACA
AGGCCACCTTTCTTATACTTCACTCCAGAGATCAGAGCGGTTCCATATGTGTCTTCCCATTCCAGAGGGA
TGGACCTTGAGTGGGGGTTCCCTGTAATAGACCAGAGAGGAACGTTCAGGCAGAAAGGCTCACACACCTG
ACATGCATCCCTTAACTAAAGTTCTATACAGAATGACTTCTGATGAAAAAGTGGCTGAGGAGGTAAAACA
TGGTCCCCCACTGAGTTTCTTCAGCACGTTTGCCAAATTCCCCACCTCATTTTAATCATCCATATAAATG
GGACAAAGTTAGTATGTGCCTCAGGTGAAACTCGGGGAAGATTATGAGGATAATTTCAGATCTCTGTAAT
AAACACTTTATAATTTAAACTAGTTCCTACACTTCTGGGCTTGGGGACTCTTCCATAAAAAAGGGGATCT
CTGGAGTTCAACATCTGGACAAAGTCTCATGATTATGTGGTCCATCTCCTCATTTAGTTTGGATTCCTTG
ACCTCTTCTTTTGGGCTAATCTCCTTCCTTTGTATTCACATAGTATTAAATGTACCTACACACAGCAAGT
ACTCAATAAATGTTTGTGGATCCAGATGAACTTGTCTACAGTCTCCATGTGATTACAGGAGCTGGTAGAC
CTCTTAGTGTGATATTTATCCACATTTTTTATGTTTATTTTTCTACTGGAGGTGCTCATACCACATTACA
CCAAACCACTTCTTCACTTTATAATCTTAGTCTGAAAGCCCACAAATGCCAGAACTCTCTTCTTACTCAA
AATAGTTCACCATTTCACCCTCTGGTGCTCCTCCTGTTGAACCTATGTCACAAATCCCCCTGCAGATTTT
GGAATGGTTGAAAAGAGTATGCTTTGCATGGGCAAGACCAAATCATACATAATTCCATAGCATTAAGTTC
TGTCAGACTAGGGTCATGAGATCCAAGAGATAAGGATGGTCTTGAGTGATAACTACAGTTGTCAGTAATA
CTTTCCAAGAGCTGCAATGGAAATTTAGCAGTTGGTCCACAGCTTTCCAAAGGCTTACTGTCCCCACCCA
CTCCTTCCAGACACAAACCTGTTAAATGGGCCACACTCCTCGGCTCTTTTTTTTCAGAGGGTGTACTGGG
GTTGGCTGCATAACAGAGAGATAAAAGACATGTGAAAATTATTATGATAAAGGCAGACTATGATATATCT
CGATAGGACTCTAAATCCCATCATTTAAATATAAGATTTTCAGAGCATAAGATGAAATATTCTAGTACAT
ACTCATGGAGAAAATCTAAACTGGGGGACTCATAGAAGTGTGTATTTCAAAAACAGTTTAAAAAGACAAG
ATAGGGAAAGATATATATATATCATTGCAATAAAACAGTGAATACAAACATTGCTGCACAAGACTGCTAT
TTCTGTTATTCCATTTAGAACTTGCCTTGGCCCCTTTAGGTCAAAATTACTCCCCTAAATATATATGATC
TGCAAAAAGATATTAGAAGCTGATTGACCATAGTGATGGAAGCAACCAATGTGCACCAAGGCTGACTGTT
ATCCTGATTCTGCTGGCTGATGAGAGTCTAGAAAAGATGACTGCTTCACCTTCTGGTTATCATCCTACAG
TCTATTCCCAAACTGACTCTATTAAGGCCTCCTCACAGGTCATGAGGTTGCCCAGATTTTTAGTTCATCA
GGTTGCCTTTGCCTTACCTCTCCTCCTCCATCACACTGAGCACTTGCACACAGCAGGAGTCCTATGACCT
AGTTATGCCCCTTCTTCCCTGTCCCTGGGCCTTTCCTCATTCTGTCTGTAACACCCTCCAGATGAGATCC
CGGTGTTAAATTCCTGTCAATTCTCTGAACACCATCTTCACTGCTCTTCCTTTGGGAAACCCTTCAGCAC
CTTTTGTCAACTATGACCCTTCAACCTTTGAAACCTAAAATCCCTCTGTCATTTCCTTTCTTGATACTTC
TGCCTTCTCCTTGCTGGGGCAAATATATATATATATATATATATATATATATATATTTGTGTGTGTGTGT
GTGTGTGTGTGTATGTGTGTGTGTGTGTATACACACATATATATATACACACACACACATACACACACAC
ATACACACACACACACACACATATATATATATCTTTGCTTTCTTCTTGTTCAGGAAAACTGTACCTTTCT
AGAATAAACACTTTATGACTAAACCAGTACTAACACTGCTGGGCTTTGAGAACCTGGCCACCAAGTCTTT
CCCTAGTGGCATTTGACAATATGGTAAAGTCACAAAGAGCATTTAGTCTGGTTTAGCACAGCATCCAATA
AATTAAATTGACATAGTTAACATTGATAATATTCTTAAAAATAAACACTGTTTCTCTAACTTCAAATATT
TCAGCTAAGGTAGAAATCTATTATTGGGCTTCATGAATTCAGCTAATTGATACATTAAAAAAATATTTAT
AGGAAGGTACTTGTCCACCTCAGGCTTGGAAGTAGACTATAAAACACACCCTGGGTGAGAAAATAGCCCA
TTCTATTGAGATCACCCTAGAAACAATCGTGTCCTTTCTCGCGTCCTCTCTAGCACCTGGGACAAGCCCC
CTTGAAAAAAGTGAGGAGCAGGATAGGCAAGACTACCACCTGAGCAGCTAACCTGGCATTCTGCCACACA
CGAACAAGAAATGGAGCAGAGAACCACACATTGCTTACCTTTATATTCCTCATACAGTCTAGTATTATGT
TATTCTCATAAAACATACTCCTATAAGTATCTGCTCGAGAGGTTCTAACAATATCCAGAAATACAAGAAA
AGATCTTTTCCTGCCTCAGGCTCCTTGCATGTGAAATGGAGAATGTCCTACCTGCTCTCTGACCCATACA
CACCTCTTCTCTCCAAGACATGTCTGGCTGATCCCTTGTGCATTAGCGCAAACCACCCTATAAAGGACTT
TTCCAGACCACTCTGCTTTGTATCATTCTTAGTACAGATTGAAACTGTGTTGTGGGTTTGTTTTTGTTCC
TCTTCTCCACTGTGCTATCAGCTTGCTGAGAAAAAGCATCCACCCTTCTTTCTCATCCTCAATCACCAAC
CAAGACTAAGCCTCTGTCATGGGAGGCTCTCTAAAGCCCTGCTATATAAATATGATGTCCAGTTAGCTAA
CTATGGGGAAGGTAGCAGTGTAAAAAGAAATAGGACCGGGCAGACGGCCGAGTGAGAAAAGGCACTTGCT
GCCGAGCCTGAGCACCTGAGTTTGATCCCTGGAACCCACAGGTAGAAGGAGAGATCTTATTCCCACAGGT
TGTTCTCTGACCTCTACGCACAAGCTCTGGCACACACATGTGCACGTGTACATAAACACACAATAAAATA
AATAAATGTTTGAAAAAGTATTTTCTTAGAAGTTTAAAAACACGCACATGCAATTTTATTATTAAACTGA
AAATGGCCTTTGATAACTTGTCTGTTTACCTAACAGCATTAAGTACGCAATATTCGTGGCATTAAAAGTC
CCACAAGGTGGTTTTGGTTGCCATGATGTTCCCCTATTGTATTTCAACTCATCTTCTATTGTGAGAGTTC
AGTTTCTTCCAAACTGTTCAAACTGTTGTTGTTTTATAAGAAAGTGATGAACACTACACACACACACATA
TATGTACTCTTAACTAAAAGAATCCTTTGGTGATGTAATTACAAGGTAGACTAACAGTTCAAGACCTTGG
AATGAACTTTCCCAGTGTTCTTCAGGATTCTTAACAGCAATTTCCATGCACATTGGATGAAACTTGTGCC
AAATATGGCTTTTTTTCCTCCCATATTTGATAATCTTTGGGTTTTTTTTCCTTTTTATGAATTTGATGGA
AGAAATAAATATTCCTTTCTTTAAATCAGCTCCTCTTGACAGTAAAGTTGCGATTTTGATACTTTTGTGA
TGGTTTATCAATTTCTGGCCATCTACGTTGGTATAAAGAAGATAAGCACTGGGGCAGGCGACCTGACTCA
TCTGTTCATTTGACTTCTATTCACTAAAACGATTCCATCGAGTGGGTGAACATGGGTGATCACCATCTGT
TTCACAAGCCATGCTCCACTGATTTCAAAAATGATTTCACTTTAGAAATCCTGAGAGGTTTTGTTTTTCT
AACAAGTTATTTACTCTGTGCCTGTGTATCCTGGGCTCTGGTCCTTTGAATGCAGAGTTGAAAATCAGAG
CACACCATGGTGACCCCTGAAAGAGCTTATATCCTCACTCAGGAGCTGACTGGTCACTGTCTGTCTTCCT
TCCTTCCTTCCTTCCTTCCTTCCTTCCTCCCTTCCTTTCCATTAATTAATTTATTCAATTTACGTCAGAT
TGCAGTCCCTCCCCTATCCTCCCCTCACACAGTCCCTCCCCCTCCTCTTCTCCTTTGAGAAGGGAGCCTC
TGCTACACCCTGTATCAATCCACTCTAGCACATCAAGTCACTCAGGACTAGACACATACTCTCCCACTGA
GACCAGACAAGGCAGCCCAATTAGGGGAATGGGATCTACAGGAAGGCAAAAGATTCAGGGACAACCCCCT
CTCCAGTTGTTGAGGGACTCACATGTAGACCAAACTGCACTGTGGTGGATCCATCCCCTTTTTATGGATG
GTTTGGTTTTCTTCAAAGTTATTAGAATACACTTGTCATGTTGCCCTTACAAAGGAAACCAGCTTTGTAT
TTGCTTCTCATTTCTGGGCCACGACTAAGAGGTGGAAGTTTCTCTATGCATTGTATAGTCCTAATAGGTA
ACAAGGCACTGGGGGACTGTTCTCCTAGTCCCAGTTTCAGACAGGAGGCTTGGGCACTGAACCTAATTGG
TCTAGTATTTTACATCTAGTATTTTTGCCTCTACTCCCCTTCTGTCCCTAGGAGTTACAGCCACCACAAC
GTAAGATGGGACCAAGATACCCTTGGAAGGAGCCAAGGGAGAAGGTCCAGGGCTATATGTGTGTCTCTTT
CCAAAGTCAAGTCCAAATTCGTTTGAGTTGTGGGCAGTGTTCATTCAGATACACTGATATTGAGCAATAA
GCTACAGTCAATATTTTCACATCGTTCACAGAACCACACTGAACGAAGAGTCAAAAGCTCCTCAGGGTTT
CATGCCTAGGAAACATAAGCCCAAGAAAGGCACAGAATCCTAGGCATCCTCCCAACTTTATTGAGTGTTG
AAGACCAGCTATGGGAACTCACAAGGCAGACATAAAAGTACTTACCTATTTGCTTTTCAAAAGATGATAC
TTTAAGGCTTTGGTTGGTGAACTAGTGAGAGAAAGAGAGTCATAGAATAAATGTGCAGTTATTTAAGCCA
AGGAAGCAGAAGTCACAGCAATCCATAGAAAGAGGACTCAGATATGTCAGACCTGGCCCGAGTTAGGGTT
TAGCCACACAATTGTATCTAGAGTAGTAGTAAGACTTCTAAGTCTCTTTGAAGAAAATTAATTTATTTAC
ACTTCTGAACAAGACACAAAATTGATTTTCATCCTTGAATCACTAAACATGAAGCAGCGAGAAGCTCATC
AAACACCCTTGACAACTCAGAGAGGAATAAGTATTTGCCTTGAATTCTCTAGAAGATGGAAAATAACTTC
CTGTGAGCAGTGGTTCTCAACATTTCTAACGCTGCATCATCCTTAAGGTTATGGCAACCCCCAACCATAA
AATGATTTCATGGTTACTTCATAACTGAAACTTTGCTACAGTTACAAACCCATAATGTAAATATCTGAGA
TGCCGAATATCTGGTATGTAACCCCCGTAAAATAGTGGTTTGACTCCCCTCACTAAGGGGTCGCAACCCA
CAGGTTGAGAACAACTCTCTTTGAGGGCGTGTGCGCCTGATTCTCCAACTCTAAAGAGACTCTAAGAACT
CTTTTCTAAATTAGAGGGGATTGAAAAGATCCTTGCCTTTAAAAACAACAACAACAACAACAACCCCAAA
TCATTGCAAGCAACACAGTAGCCCACATGGGCCATAGCAAGTCCCTACTCCCACGCAGCAGAGTCAGGTT
GCAGCCAGGAACGCGAGGGCTGCTAATCCATGTGCTAGGCTTACCTCACGGAGTTCTGCCAGTTCCTTCT
GCAGGTGGAAGAGCTGATACATTCCTAATCCCATTCCAACCAGAGCCACCAGAACCATGAAAAATACCAC
CGGTAGCCACAGATTTGTGTTGTGGTCCTTCTTCTTTAGAGGGGTCAGTGGCGGCAGTGGGAGTGGTTGT
GATGGCGGTGGTAGTGGTGACACAGGTGGTGGTGGAGGTGGCGGTCTCCTTTGGTCCGGCCCTCTAGGCC
CACAAGATGGACAGGGAAAAACTGACCCTGGAGGAGCCCAAGATGAAGTGGCACTGCTGTCTACCCAGAA
GATCTGGGGACATGGGTAATTCATGGGCTGCTGCATGGCACCCAGCCCCAGGAAAGGGTTTCCTTCTCAC
AGCCTTGTGGAGGAGACTCAGGTGTCAAGGACAGAACTCTGACGCTGACTGCTCCAGAGAAGCTAAGTTT
TCTTTATAAAGTTTCCGCAGTCAAGGGAAACACCTTTCTCCTGTTCTCTTCTCTTTGCTTCTCTGTGAGA
CACCCACTCACTTGCATCTGAAGCTGAGAAGCCTC
Protein Information
Protein Name transcript variant 2
NCBI Protein GI 327478405
Protein Accession NP_001192172
Protein pI 10.08
Protein Weight 13560
Protein Length 131
Protein Note Also known as gld; CD178; CD95L; Fas-L; Faslg; CD95-L; Tnfsf6; APT1LG1; Fas-Ligand
Protein Sequence 
>NP_001192172.1 tumor necrosis factor ligand superfamily member 6 isoform 2 [Mus musculus]
MQQPMNYPCPQIFWVDSSATSSWAPPGSVFPCPSCGPRGPDQRRPPPPPPPVSPLPPPSQPLPLPPLTPL
KKKDHNTNLWLPVVFFMVLVALVGMGLGMYQLFHLQKELAELREPTPVHPLKKKSRGVWPI
Epitope Information
IEDB Linear Epitope