VIOLIN: Vaccine Investigation and Online Information Network

FASLG

General Information

Protegen ID

301

Sequence Strain (Species/Organism)

Homo sapiens

Taxonomy ID

9606

Molecule Role

Protective antigen

Molecule Role Annotation

Introduction of human CD95L (FASLG) cDNA into murine tumor cells did not affect growth in vitro but caused rejection in vivo. Neutrophils were primarily responsible for this rejection. A CD8 T cell-mediated protective immunity against subsequent challenge with parental tumor cells was also elicited (Seino et al., 1997).

References

Seino et al., 1997: Seino K, Kayagaki N, Okumura K, Yagita H. Antitumor effect of locally produced CD95 ligand. Nature medicine. 1997; 3(2); 165-170. [PubMed: 9018234].

Gene Information

Gene Name

FASLG

NCBI Gene ID

356

Genbank Accession

AB013303

Chromosome No

Gene Starting Position

172659007

Gene Ending Position

172666872

DNA Sequence

>NC_000001.11:172659007-172666872 Homo sapiens chromosome 1, GRCh38.p12 Primary Assembly
CAGAATCAGAGAGAGAGAGATAGAGAAAGAGAAAGACAGAGGTGTTTCCCTTAGCTATGGAAACTCTATA
AGAGAGATCCAGCTTGCCTCCTCTTGAGCAGTCAGCAACAGGGTCCCGTCCTTGACACCTCAGCCTCTAC
AGGACTGAGAAGAAGTAAAACCGTTTGCTGGGGCTGGCCTGACTCACCAGCTGCCATGCAGCAGCCCTTC
AATTACCCATATCCCCAGATCTACTGGGTGGACAGCAGTGCCAGCTCTCCCTGGGCCCCTCCAGGCACAG
TTCTTCCCTGTCCAACCTCTGTGCCCAGAAGGCCTGGTCAAAGGAGGCCACCACCACCACCGCCACCGCC
ACCACTACCACCTCCGCCGCCGCCGCCACCACTGCCTCCACTACCGCTGCCACCCCTGAAGAAGAGAGGG
AACCACAGCACAGGCCTGTGTCTCCTTGTGATGTTTTTCATGGTTCTGGTTGCCTTGGTAGGATTGGGCC
TGGGGATGTTTCAGCTCTTCCACCTACAGAAGGAGCTGGCAGAACTCCGAGAGGTAAGCCTGCCGGCAGA
CTGCTGTGCCCTGGAGGCACCAGGCATAAGGGGATGGAGGGCCCACTGCCTGGCTTGCAAAGTGCTTTTC
AATCCTTTTTTTTTTTTTCTTAGAAATGGGTTGTTCTAGTTATTCTATTCTATAGACAGAGAAATGGAGG
CTCATAGGGGTGAAGGGAATATTTTTTACTTTGTAAAGAATCAGAGCCCAACAGTTTGTCTTTCCTCAGT
TGTCAACTCAGTCTGTTGAACCACTTACTGCCTCATACCTATTGATTTAAGGAGTAAAAAACAAACAAAC
AAAACTTTTAAGTTTTGCTTGGAAGTAAATTTGTTCAGATGACCAAACTAAATCTTGAAAATTGGTACGA
TTCCAAATCACAAAACTGAGGGACAGTGAGGCAAAATTGCTTGGCCAAAGCCCAAGTTAGCAGAACTTCT
GAGGTATTTGGATTCTCTTTCCAGGGCTTGGTTTATTTGACGATTCTGCCTCTTTTGCTTAAAGAATTTT
ATTTTTATTATACATCTTTTCTCTTTCTGTTTTACTAGTCTACCAGCCAGATGCACACAGCATCATCTTT
GGAGAAGCAAATAGGTGAGTCTTTTTTCGCATGTACATTGAGTTCCCAAAGATGATCCTCAGCACAGAAC
TATGTTAATGGAATGCCTTAAATTCTGTCCCACACTTTGGTTTCTGTACACTATAAGAGGAATTCTGGCT
AATTCAGAATCTCTGGTCTATGATTCCTTGAGCTGCTTTAAAAATGTGAAGTGAATTGAATTGCTCACAA
TCAATATAGCTGAGCACTGCACACAATTCAAAATCACTTCCACTTGACTTTGGAAAGAGACACACATATA
CAACCCTGGACCTTTGCCCCCTGAGAAGTGGCTCCAGGCCTGTCCCCTTCCACAGACATCCTGGTCCTGG
CACACACGCCAGTGGCTGTAACTCCTGGGAAGAGAAGGCGAAATGAAGGCAGAGACAGATGTTTCTGAGA
AACGTCCTTTCCTCTTTTAAATGCCCTAAAGAGATTACATTGAAGCTTTATTTACAATATGTTTTATAGG
ATGTAAGCTTTTAAAACATGGATAATCAATTCCCCACATTAGAATGGTTTTTCTTGAAGTCACTGAGAAG
CTTAAGGGAAGACTTCAGCCATCATTCAAAGGATGTTCAGCTTCACCCACAGAGGCAGTCATGAGGTACC
CTTGATCACAAAGGAAAATCCTTTGTATGGGAGCTAGGGCAAGAAGATGATAGGTTGAACACTGATCTCA
TGAAATTTCAGGGCATAGTTGTGCAAGCTCTGTACAGATAGATTTTACAGTGTGCTTCACTAGTCTAAGA
TTCATTGAAATTTTAGATTTAGATTTACAATGAGATTCATTGAATTTTTAGAGGTGGAAGGAAGCTTAGA
ATATATCTAGTCCAGCCATTTCATTTTTTGGAAGAGAAACAAAATACCAGATGGATTAGGTGAATATGCC
CAAGACCACTGGTATGCCATTGGGGCTAGAAGGAACACAGGCTCTTGATGCCTTGTCACCTACAGGGCTT
TCCAGTACTGGACTGGTGCCTCATGAAGGAGGGAAACTCCTGTCTCTCTGTAGTGAGCATGGAATAAGAA
ATAGATGAAAAGCAGGATACCTCTGCAAAGACTATAGGTAGATCTCATCCTTAGAAACTCAGAATAAAGA
AGAAGGCAGCACTGGCCATCTATTAAGTGAAGCAAGTTCCAGTTTCTCCGGATGTGGCTACTGCACATGA
CCCAGTCGCCTGTCTACTATCCTAGACTGTTAAGTTCTTATATGAGCCACTGTTGGGATGCTCTGGCCCC
TGCTTCTGTGTCCTAATCCTTAAATGTTAGAAAGTCCATATGTACACAAGCAGAGTGGAAATATTTGATA
GAAAAGTAAAGCCTCTGGAGGACGTCTGAAATAAGATCATTTTGAAAATCTGTGGAATGTGCCTGGTCTG
ATAGGTATCTAATTATTCATCTTTCACCCACTCTCTGGAGTCAATTTAGTGATTAAAAGTCAAATGATCA
GGTGAGTCAGATCCATCTACCCCAGTAAGCAATTATGTTCTCTAGATCAACCCAAATAAACCAGAAATTG
GTAAATCATCACATGGAAATCAAATCAGTAACTTTACTAATAAGAAAAGAGATGCAAATTAAAAATAGGG
AATACCAATTTTCATCAAATTAATAAAGATTAAAAAAAAACCCAGACTGACAAAGATTTGAGAGAAAAGT
GCCTGTGCAAACATTAGTTTCAGCCAGTATACATGTAAATTGCTATAACTTTTTTTGAAGAGCGCTTTAG
AAATACATAGCAAAAGCTTGTAACTAGTAGTTTACGTTGTAATCCTATCGCTAAGAATTTATCTTAAGAA
AATAATCAGAGATGTGCCCGAAGATTTATATATAAGGATGTTCATTACTTCCTTATGAGCCTATTTATAA
TAAATAATTCAGAAGAAACTTGAATGCCTCATACGAGATTAGTTATATACATTATGGTGTATTCAGACAA
GCACATAATAAGCAGCAACTAAAAGTGATGTATCAGAAGGACATTTAATGCTTTGGGGATTGTGCACTCT
GTATTGTTAGATAAAAAGACAAGTTACAAAAGGGTATGTTTAGTTTCATACTGACTATGTAACCATGTAT
GCACATTTTTATATTCTTAGGAACTGGAAAGTTTTACACACTGACATACTAACAGTGATTTTCTCTGGGA
GATACTATTATAGATTATTTATACTTTCTAATTTGCTCCTTTTTACATTTTCCATTTTTTTCCGGTTAAC
TAATTAAATCTTTTATTCATTCACATGTGTGAGGCTAGATGTTGGGTGTTGGATGCTGATTGAGGATGAG
CCAGCCCAGGGGGCCTGTCCTTATGGAGCTTTTAGCAGGGGGAAGAAGCTAAACAAAAGCAAGCAAACAG
ACCATGCAATTCCAAAGTTGTACTAAGTACAACCTGAGAATCTTCTTTAAGGAGGTGTTGTTTACGCTAA
CACCTTGGGGGTCAGAAGCCCGATGAGTGAACGGCTGTGTGCATGTGCTGTGGAGTGGGGTGGGGCTGGG
GGCGGGCATTTCAGCGCTGGGAACGGCACATGCAAAAACCCTGGGGCAGGAAGCACTCATAACCAGTGTC
TAGGATATCCTTGCAATTTATTTATTCCAGTATAGGTACAGCAGATATTCTTAGTGAGCATGTTCTGTAA
GAATAACGTTGTACTAGGCTCTGTGAGGGATATAAAGACATGCAACATGTGGTTCTCTGTTCCGTTTCCT
GCCGGTGCGTGGCTGAGTGCCAGATTAGTTGCTCGGGTGGTTTGCGGTGTAGGAATGCAGAGGAGACTCA
GTTTTGCCTTTCCTGTTCGCTAACACCTCCTACATGGTGGGTTGTCTTGGATGACTAGAGAGGTCATGAT
TGCTCAGCTAATGTTCTCTGTGGATTGGGCCATTCTCATACCATATGTGAGTTTTACAGGCTAATCACGA
ACCTGACATAGACAAGCATCTCCTGTGAATATTTATTGAAGTCTCAGTTAGCTGAATTCATTAGCTAAGT
GGCAGCTGTCTATCTTGTCTGAAACAGTTGAAGTCAGAGAAATAGTGTCTGTTTTGAGAACTATTGTCTA
TCCTTCCATTTAATTTGTCCAACATTTGCTAGTAACATGCCCTGTGTTAGAAACTGGGCTTCTCTGGTGA
ACTCAACGTATCGTAAGGAACTTGTCGTTATTTGAGGGGAATAAGATAATTTATGTAGTTACCCCAGAGA
CAAGAGGAGTCAGAAATGACAAGAGAGGGGAAGACAGAGGGATCCTAGATTTCAAAAGAGGGGCAGATCA
TATTTGATCAAAAAAGGCTTGAGAGGGTTTCCCAAAGAAAGCGGTAATAGGTAGTCCTTATGGGATGTTT
AGGAATTTGACACAGAAATCTGCTTGAAAGAACATTACGGGCAGAAGACATGGCATGAACAAAGGCACAG
AGGAAGGAAAGTGGGGGTATGTGTAGGCCACAGAACTCCCGTTGTGTGGCAATGCTCAGTGGGAGTAAGG
AGATAAGGCTGGACAGATGGGCTGGGATTGTGTGATGGGGATACTTGTATACGACGGCATCTTCGGGGAG
GAGCAATTAAAGGTGTTTGAGGACTCAGTGATATGAGGTGATTGTCAGAGGTCTTAAGATAATTAATTTG
GGGCAGATTGTAAAATGTCACTGGGGGAAGATCTGGTGACACGCAGACAGATCAGTAGTCTTCTTCAGCC
TCTGTCCTGTAAGTCTTTGGAACAAGAGAATCAGAGTGGACAGAGCCCTGGAATTGGCGTCAGGAGAGCA
GGGTGTGGTCCCATCTGTGATGCTGACTAGCTGGGTCTTCTTGGATTAGTCACCCAACTTCTAAGCTCAT
TTTGCAATCGATAAGGTGGGACAATAATACCTACCTCAAAGGGTTGTGGTGAGTTCTAAATGCAATAACT
GACATGACAGCTCTTTATGAATAAATGTTTATATTAATTATGTTTTATTGTAACATTATAATTTATACAT
ATGTCAATCTTAATTTGGTTTATTTTTTTACCTCTTTGTTTCTGAAATATAGACTACTATGAATCCTGCA
GTTCAGACCTACATGATTAGTATATGTTAGACTGTTGCCATTTACGGTTTTAAAATCTTTTTTTTAAAAT
GATTGGATTTAAATTCCCACCAAAATAATAGTTGCTATTTCATTTTAACATATATTTTTCCTCTCTCTAT
GATACAGGCCACCCCAGTCCACCCCCTGAAAAAAAGGAGCTGAGGAAAGTGGCCCATTTAACAGGTCTGT
ATCTGGAAGGTACAGGTGAGATTTGGGAAAGCTTTTGGCAAAAGGCAAAATGGCTGCCTGGTTTCCATTA
CCAGGCTCTAGAGAGTTGTTACTTCCTGGAGACAGTATTTGAACCCAATAATACTAACACTTTTCTTGTC
GAGTCAGTCTTATGAACACACTTTGATCCCCTATTCTCTGGGCAAGGCCCTCTTCTAAATTGGAGACCTG
GAGCTGATTATGACATGACCCCTGCCCATAAGAAGCTCATTCTTTTCAGTCATTCCAAAGTCCCTTGGGG
GATTGGGGGCACAGATCCAAGAGGTGAGAGATGAGAAGGTGAGGAATGAGGACTTATTTTAGTCAGTGCT
TTCTTGGTTTTCTGGAAGAGCTTCACTCTGCTTTGTCCAAGAGTATAAATAGGAGTGAGAAGGGAGACTC
AATCCTGGCACTTGTAGAGTTTCAATATGTGCCTGTAAAGTGGAGTGAAATGATATGGTATGGGCACTCC
CATTATAAACTACATAAATAATGGAATAAATATCACAGAAAGTGGTAGGCTATTGTCCCTGGAATTATTT
AGGCAGAAATTATAGAATGATCCGGTCACATCAGCAGACACTTACTGAATACCTGCTGTGTGCCAATTTG
GGGATGTGAAGATGAGTAGCACATGGCTCTTGCCCCCAGGGAGCTTGACATCTAATAGGGAAAGACAGGC
ACTTATGATAATTTCAGTACTTCAGAGATTTAGGTTATGTTCATGATGTTGTGGGGATACAAAGAAAAGG
GAACTGTACCCCAAATTGAGGGGCTGAATAATTCTTACTGCAGGTGAGAAGATGGACCAGATGGTCCCTA
AGATCCTTCCCAACTTTAGAACTTTAGAGTTCCTTGGATTTGGCTTTTTCCTTCAGGAAAGGACTTCAAA
GCCTAGCAGATTTGGTGCTAGTTCTGAAGATAGTAAAATCTTTGTTCCAGAGAGCAAATATTTTCTCAAT
AATTTCTTACTGCAATGGATTACGGGTATATACTATTGTTCCAATTGTGTGGATGACAAAATAGGACAAC
GTTGTTGAGGAAATTCTGTGATGGATCAAGTTCTGACCCCTCAGCCAGTTCTATACCAGCTGTCATTCTG
GGTGAAACATTTGTTGAAGGAAGGGCCCACAGTTTTGCCTTAGAAACTTAGTTTGTTGGATGCATGACTA
TTCCTTGTTGAAAGCTCCTTTTGGATTTATTTCAGGCAAGTCCAACTCAAGGTCCATGCCTCTGGAATGG
GAAGACACCTATGGAATTGTCCTGCTTTCTGGAGTGAAGTATAAGAAGGGTGGCCTTGTGATCAATGAAA
CTGGGCTGTACTTTGTATATTCCAAAGTATACTTCCGGGGTCAATCTTGCAACAACCTGCCCCTGAGCCA
CAAGGTCTACATGAGGAACTCTAAGTATCCCCAGGATCTGGTGATGATGGAGGGGAAGATGATGAGCTAC
TGCACTACTGGGCAGATGTGGGCCCGCAGCAGCTACCTGGGGGCAGTGTTCAATCTTACCAGTGCTGATC
ATTTATATGTCAACGTATCTGAGCTCTCTCTGGTCAATTTTGAGGAATCTCAGACGTTTTTCGGCTTATA
TAAGCTCTAAGAGAAGCACTTTGGGATTCTTTCCATTATGATTCTTTGTTACAGGCACCGAGAATGTTGT
ATTCAGTGAGGGTCTTCTTACATGCATTTGAGGTCAAGTAAGAAGACATGAACCAAGTGGACCTTGAGAC
CACAGGGTTCAAAATGTCTGTAGCTCCTCAACTCACCTAATGTTTATGAGCCAGACAAATGGAGGAATAT
GACGGAAGAACATAGAACTCTGGGCTGCCATGTGAAGAGGGAGAAGCATGAAAAAGCAGCTACCAGGTGT
TCTACACTCATCTTAGTGCCTGAGAGTATTTAGGCAGATTGAAAAGGACACCTTTTAACTCACCTCTCAA
GGTGGGCCTTGCTACCTCAAGGGGGACTGTCTTTCAGATACATGGTTGTGACCTGAGGATTTAAGGGATG
GAAAAGGAAGACTAGAGGCTTGCATAATAAGCTAAAGAGGCTGAAAGAGGCCAATGCCCCACTGGCAGCA
TCTTCACTTCTAAATGCATATCCTGAGCCATCGGTGAAACTAACAGATAAGCAAGAGAGATGTTTTGGGG
ACTCATTTCATTCCTAACACAGCATGTGTATTTCCAGTGCAATTGTAGGGGTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTATGACTAAAGAGAGAATGTAGATATTGTGAAGTACATATTAGGAAAATATGGGTTGCA
TTTGGTCAAGATTTTGAATGCTTCCTGACAATCAACTCTAATAGTGCTTAAAAATCATTGATTGTCAGCT
ACTAATGATGTTTTCCTATAATATAATAAATATTTATGTAGATGTGCATTTTTGTGAAATGAAAACATGT
AATAAAAAGTATATGTTAGGATACAA

Protein Information

Protein Name

transcript variant 1

NCBI Protein GI

4557329

Protein Accession

NP_000630

Protein pI

9.71

Protein Weight

29599.28

Protein Length

281

Protein Note

Also known as FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1

Protein Sequence

>NP_000630.1 tumor necrosis factor ligand superfamily member 6 isoform 1 [Homo sapiens]
MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPP
LKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEK
KELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHK
VYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYK
L

Epitope Information

IEDB Linear Epitope