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Bfr from B. melitensis biovar Abortus 2308

General Information
Protegen ID 255
Sequence Strain (Species/Organism) Brucella abortus 2308
VO ID VO_0010968
Taxonomy ID 359391
Molecule Role Protective antigen
Molecule Role Annotation Brucella bacterioferritin is a protective antigen (Al-Mariri et al., 2001)
COG COG2193P, under P: Inorganic ion transport and metabolism
References
Al-Mariri et al., 2001: Al-Mariri A, Tibor A, Mertens P, De Bolle X, Michel P, Godefroid J, Walravens K, Letesson JJ. Protection of BALB/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant. Infection and immunity. 2001 Aug; 69(8); 4816-22. [PubMed: 11447155 ].
Gene Information
Gene Name Bfr from B. melitensis biovar Abortus 2308
NCBI Gene ID 3828133
Genbank Accession JMRZ01000012
Chromosome No II
Locus Tag BAB_RS29555
Gene Starting Position 673934
Gene Ending Position 674419
DNA Sequence 
>NC_007624.1:673934-674419 Brucella melitensis biovar Abortus 2308 chromosome II, complete sequence, strain 2308
CTTACTCAGCTTCGTCGGCGGGCGCCGCGTTAAGCTGGCCATAGCGTTCTCCGCCGATCTTGGCGAGAAG
GTCAAGCTGGGTTTCAAGGAAGTCGATATGGCCTTCTTCATCGGCCAGAAGTTCGTCGAAAAGCTGCTTC
GACACATAGTCGCCGAGCTTGTCGCAGATTTCGCGCGATTCCTTATACGAAGCGCGAGCGTCATATTCAC
CCTTGAGGTCAGCTTCGAGAACTTCCTTCACATTCTGGCCAATGCGCAACGGCGAAACGGTCTGGAGGTT
CGGAAAGCCTTCAAGGAAGATAATGCGATCAATCAGCTTGTCGGCGTGATGCATTTCCTCGATGGATTCC
TCGCGTTCCTTCTTTGCAAGGCGCGTGTAACCCCAATCGTTGAGAAGACGGTAGTGCAGCCAATACTGGT
TTACCGCACCGAGCTCAAGAAACAGTGCCTCGTTAAGCCGCTCGATGACCTTTGGTTCGCCTTTCA
Protein Information
Protein Name bacterioferritin
NCBI Protein GI 489055925
Protein Accession WP_002966069
3D structure: PDB ID 3FVB
Protein pI 4.42
Protein Weight 17971.98
Protein Length 161
Protein Sequence 
>WP_002966069.1 MULTISPECIES: bacterioferritin [Brucella]
MKGEPKVIERLNEALFLELGAVNQYWLHYRLLNDWGYTRLAKKEREESIEEMHHADKLIDRIIFLEGFPN
LQTVSPLRIGQNVKEVLEADLKGEYDARASYKESREICDKLGDYVSKQLFDELLADEEGHIDFLETQLDL
LAKIGGERYGQLNAAPADEAE
Vaxign Prediction
Localization(Probability) Cytoplasmic
(Prob.=0.997)
Adhesin Probability 0.133
Trans-membrane Helices 0
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope