The purified recombinant proteins, P1, HspB, and P1-HspB, and whole-cell antigen (WCA) of C. burnetii were used to immunize BALB/c mice. Protective immunity against Q fever was induced with a recombinant P1 antigen fused with HspB after Coxiella burnetii challenge (Li et al., 2005).
The identification of 37 SEPs and show that 30 react with sera from mice immunized with Cox. burnetii and sera from patients with Q fever. (Jiao et al., 2014)
Jiao et al., 2014: Jiao J, Xiong X, Qi Y, Gong W, Duan C, Yang X, Wen B. Serological characterization of surface-exposed proteins of Coxiella burnetii. Microbiology (Reading, England). 2014; 160(Pt 12); 2718-2731. [PubMed: 25298245].
Li et al., 2005: Li Q, Niu D, Wen B, Chen M, Qiu L, Zhang J. Protective immunity against Q fever induced with a recombinant P1 antigen fused with HspB of Coxiella burnetii. Annals of the New York Academy of Sciences. 2005; 1063; 130-142. [PubMed: 16481504 ].
