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YopE

General Information
Protegen ID 1074
Sequence Strain (Species/Organism) Yersinia pestis KIM 10
Taxonomy ID 187410
Molecule Role Protective antigen
Molecule Role Annotation Immunizing mice with a single peptide, YopE(69-77), suffices to confer significant protection from lethal pulmonary challenge (Lin et al., 2011).
Related Vaccines(s) YopE(67-77) Protein Vaccine
References
Lin et al., 2011: Lin JS, Szaba FM, Kummer LW, Chromy BA, Smiley ST. Yersinia pestis YopE Contains a Dominant CD8 T Cell Epitope that Confers Protection in a Mouse Model of Pneumonic Plague. Journal of immunology (Baltimore, Md. : 1950). 2011; ; . [PubMed: 21653834].
Gene Information
Gene Name YopE
NCBI Gene ID 1149129
Genbank Accession AF053946
Locus Tag YKCD1p59
Plasmid No pCD1
Gene Starting Position 44185
Gene Ending Position 44844
DNA Sequence 
>gi|31795262:44185-44844 Yersinia pestis KIM plasmid pCD1, complete sequence
ATCACATCAATGACAGTAATTTCTGCATCTGTTGCGCCAGCCCTTTGATCTCATTTGCTGCCTGCGTTAG
ATCAACGCCACTGGCGACGTACGCGCTGGCCGCCCCACCAATAGTTCCCCACTGCGAGAAGGGAATACCA
CAAACAGGCGTGTTTAAGATGGCACTGGCCTCAGCTTGCAATTCCCCACCACAAAACTGCATCAGCCCTT
GGCATTGAGTGATACTGCCACGAAGAGGGCCGCTGCCCGTAGCGAACTGATCATGATTTTTCTGCAGCAT
CTCTGCATCCAAGCTATTCAACTGCTGCATGTATTTTGGCAGCGTCTCAGCAGCAAGTTGCTTGATACTG
TCACTGAAAGACGTAGGACTTGGCATTTGTGCAGGTGTGGGTGCTGGTGTCACCACCGGTTTATGGCTCC
CCTCCGAGAACATGCGTTGGATAAACCCAATCACAGAGTGGGCCACTGATGATAACCTCTCAATGATACG
GCTGGCTAAGCTGGAACCCTGAGGGCTTTCAGTGCGCCCGGCCAGATTGTTTGCATATTGATCACTTGTT
TGCTGTGAGACTGAGCGCCCAGACATTTCTCCTACGCTGCTAGATCCTGACACAGATGTCGGCAGGGGCA
GTGATGTAGAAATAAATGATGATATTTTCA
Protein Information
Protein Name secreted effector protein
NCBI Protein GI 31795304
Protein Accession NP_857762
Protein pI 6.77
Protein Weight 21994.2
Protein Length 219
Protein Sequence 
>gi|31795304|ref|NP_857762.1| secreted effector protein [Yersinia pestis KIM]
MKISSFISTSLPLPTSVSGSSSVGEMSGRSVSQQTSDQYANNLAGRTESPQGSSLASRIIERLSSVAHSV
IGFIQRMFSEGSHKPVVTPAPTPAQMPSPTSFSDSIKQLAAETLPKYMQQLNSLDAEMLQKNHDQFATGS
GPLRGSITQCQGLMQFCGGELQAEASAILNTPVCGIPFSQWGTIGGAASAYVASGVDLTQAANEIKGLAQ
QMQKLLSLM
Epitope Information
IEDB Linear Epitope