|
Burkholderia pseudomallei aroC deletion mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002825
- Type: Live, attenuated vaccine
- Status: Research
- aroC
gene engineering:
- Type: Gene mutation
- Detailed Gene Information: Click Here.
- Preparation: An unmarked aroC deletion mutant of B. pseudomallei strain A2 was constructed using a sucrose counter-selection strategy. The aroC deletion in the resultant mutant, designated A2DeltaaroC, was confirmed by PCR, Southern hybridization and failure of the mutant to grow in a defined medium without aromatic compound (Srilunchang et al., 2009).
- Immunization Route: Intraperitoneal injection (i.p.)
|
| References |
Srilunchang et al., 2009: Srilunchang T, Proungvitaya T, Wongratanacheewin S, Strugnell R, Homchampa P. Construction and characterization of an unmarked aroC deletion mutant of Burkholderia pseudomallei strain A2. The Southeast Asian journal of tropical medicine and public health. 2009; 40(1); 123-130. [PubMed: 19323044].
|
|
Burkholderia pseudomallei asd mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002826
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- asd
gene engineering:
- Type: Gene mutation
- Description: This asd mutant is from Burkholderia pseudomallei (Norris et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
|
| References |
Norris et al., 2011: Norris MH, Propst KL, Kang Y, Dow SW, Schweizer HP, Hoang TT. The Burkholderia pseudomallei {Delta}asd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice. Infection and immunity. 2011; ; . [PubMed: 21807903].
|
|
Burkholderia pseudomallei purM mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002827
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- purM
gene engineering:
- Type: Gene mutation
- Description: This purM mutant is from Burkholderia pseudomallei (Breitbach et al., 2008).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
|
| References |
Breitbach et al., 2008: Breitbach K, Köhler J, Steinmetz I. Induction of protective immunity against Burkholderia pseudomallei using attenuated mutants with defects in the intracellular life cycle. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008; 102 Suppl 1; S89-94. [PubMed: 19121696].
|
|
Burkholderia pseudomallei purN mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002828
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- purN
gene engineering:
- Type: Gene mutation
- Description: This purN mutant is from Burkholderia pseudomallei (Breitbach et al., 2008).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
|
| References |
Breitbach et al., 2008: Breitbach K, Köhler J, Steinmetz I. Induction of protective immunity against Burkholderia pseudomallei using attenuated mutants with defects in the intracellular life cycle. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008; 102 Suppl 1; S89-94. [PubMed: 19121696].
|
