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Vaccine Comparison
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CVD 103-HgR- REPEC |
rBCG -Stx2B (Escherichia coli ) |
| Vaccine Information |
Vaccine Information |
- Vaccine Ontology ID: VO_0004721
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: Rabbit Enteropathogenic E. coli (REPEC), a member of the AEEC family. The C-terminal portion of intimin was delivered by the attenuated Vibrio cholerae vaccine strain CVD 103-HgR. To export intimin, a fusion was engineered with ClyA, a secreted protein from Salmonella enterica serovar Typhi (Keller et al., 2010).
- Immunization Route: Intramuscular injection (i.m.)
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- Vaccine Ontology ID: VO_0004657
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- StxB2
gene engineering:
- Type: Recombinant vector construction
- Description: A novel vaccine against Shiga toxin (Stx)-producing Escherichia coli (STEC) infection using a recombinant Mycobacterium bovis BCG (rBCG) system expressing the Stx2 B subunit (Stx2B) (Fujii et al., 2012).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: rBCG expressing the Stx2 B subunit (Stx2B) (Fujii et al., 2012).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
References |
Keller et al., 2010: Keller R, Hilton TD, Rios H, Boedeker EC, Kaper JB. Development of a live oral attaching and effacing Escherichia coli vaccine candidate using Vibrio cholerae CVD 103-HgR as antigen vector. Microbial pathogenesis. 2010; 48(1); 1-8. [PubMed: 19878715].
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Fujii et al., 2012: Fujii J, Naito M, Yutsudo T, Matsumoto S, Heatherly DP, Yamada T, Kobayashi H, Yoshida S, Obrig T. Protection by a recombinant Mycobacterium bovis Bacillus Calmette-Guerin vaccine expressing Shiga toxin 2 B subunit against Shiga toxin-producing Escherichia coli in mice. Clinical and vaccine immunology : CVI. 2012; 19(12); 1932-1937. [PubMed: 23035176].
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