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Vaccine Comparison
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AdC68- rabies virus glycoprotein |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004630
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- G
gene engineering:
- Type: Recombinant vector construction
- Description: A plasmid vector, termed pSG5rab.gp, that expresses the rabies virus glycoprotein under the control of an SV40 early promoter (Xiang et al., 1994).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Chimpanzee adenovirus (Ad) vector serotype SAd-V24, also termed AdC68, expressing the rabies virus glycoprotein (Xiang et al., 2014).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Xiang et al., 1994: Xiang ZQ, Spitalnik S, Tran M, Wunner WH, Cheng J, Ertl HC. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology. 1994; 199(1); 132-140. [PubMed: 8116236].
Xiang et al., 2014: Xiang ZQ, Greenberg L, Ertl HC, Rupprecht CE. Protection of non-human primates against rabies with an adenovirus recombinant vaccine. Virology. 2014; 450-451; 243-249. [PubMed: 24503087].
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ALVAC-RV |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004728
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: A non-adjuvanted feline rabies vaccine developed using the canarypoxvirus vector (Jas et al., 2012).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Jas et al., 2012: Jas D, Coupier C, Toulemonde CE, Guigal PM, Poulet H. Three-year duration of immunity in cats vaccinated with a canarypox-vectored recombinant rabies virus vaccine. Vaccine. 2012; 30(49); 6991-6996. [PubMed: 23059358].
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BV-RVG/RVG |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004651
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Glycoprotein G
gene engineering:
- Type: Recombinant protein preparation
- Description: The recombinant baculovirus (BV-RVG/RVG) was pseudotyped with the rabies virus glycoprotein (RVG) and also simultaneously expressed another RVG under the control of the immediate early CMV promoter (Wu et al., 2014).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Recombinant baculovirus (BV-RVG/RVG) was pseudotyped with the rabies virus glycoprotein (RVG) and also simultaneously expressed another RVG under the control of the immediate early CMV promoter (Wu et al., 2014).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Wu et al., 2014: Wu Q, Yu F, Xu J, Li Y, Chen H, Xiao S, Fu ZF, Fang L. Rabies-virus-glycoprotein-pseudotyped recombinant baculovirus vaccine confers complete protection against lethal rabies virus challenge in a mouse model. Veterinary microbiology. 2014; 171(1-2); 93-9101. [PubMed: 24793501].
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RCN-rabies-G |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004693
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Glycoprotein G
gene engineering:
- Type: Recombinant vector construction
- Description: A recombinant RCN vaccine expressing the rabies-G glycoprotein (RCN/rabies-G) (Osorio et al., 1999).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Recombinant RCN vaccine expressing the rabies-G glycoprotein (RCN/rabies-G) (Osorio et al., 2003).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Osorio et al., 1999: Osorio JE, Tomlinson CC, Frank RS, Haanes EJ, Rushlow K, Haynes JR, Stinchcomb DT. Immunization of dogs and cats with a DNA vaccine against rabies virus. Vaccine. 1999; 17(9-10); 1109-1116. [PubMed: 10195621].
Osorio et al., 2003: Osorio JE, Frank RS, Moss K, Taraska T, Powell T, Stinchcomb DT. Raccoon poxvirus as a mucosal vaccine vector for domestic cats. Journal of drug targeting. 2003; 11(8-10); 463-470. [PubMed: 15203914].
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rLSDV-Rabies-gP |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004762
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Glycoprotein G
gene engineering:
- Type: Recombinant vector construction
- Description: Recombinant LSDV encoding the rabies glycoprotein (rLSDV-RG) (Aspden et al., 2003).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Using the rabies virus glycoprotein (RG) as a model antigen, the recombinant LSDV encoding the rabies glycoprotein (rLSDV-RG) was able to express RG (Aspden et al., 2003).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Aspden et al., 2003: Aspden K, Passmore JA, Tiedt F, Williamson AL. Evaluation of lumpy skin disease virus, a capripoxvirus, as a replication-deficient vaccine vector. The Journal of general virology. 2003; 84(Pt 8); 1985-1996. [PubMed: 12867628].
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rORFV-RabG |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004766
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- RABVgp1 nucleoprotein N
gene engineering:
- Type: Recombinant vector construction
- Description: Orf virus (ORFV) recombinant, D1701-V-RabG, expressing the rabies virus (RABV) glycoprotein that is correctly presented on the surface of infected cells without the need of replication or production of infectious recombinant virus(Amann et al., 2013).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Orf virus (ORFV) recombinant, D1701-V-RabG, expressing the rabies virus (RABV) glycoprotein (Amann et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Amann et al., 2013: Amann R, Rohde J, Wulle U, Conlee D, Raue R, Martinon O, Rziha HJ. A new rabies vaccine based on a recombinant ORF virus (parapoxvirus) expressing the rabies virus glycoprotein. Journal of virology. 2013; 87(3); 1618-1630. [PubMed: 23175365].
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