Vaxvec

Vaccine Detail

HSVT[VP7/6/2]

Vaccine Information

Vaccine Ontology ID: VO_0004687
Type: Recombinant vector vaccine
Status: Research
Host Species for Licensed Use: Baboon
VP2 gene engineering:
- Type: Recombinant vector construction
- Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
- Detailed Gene Information: Click Here.
VP6 gene engineering:
- Type: Recombinant vector construction
- Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
- Detailed Gene Information: Click Here.
VP7 gene engineering:
- Type: Recombinant vector construction
- Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
- Detailed Gene Information: Click Here.
Vector: Herpes simplex virus vaccine 1 vector
- Vactor Name: Herpes simplex virus vaccine 1 vector
- VO ID: VO_0001068
Preparation: Herpes simplex virus type 1 (HSV-1) amplicon vectors were constructed to coexpress the rotavirus (RV) structural genes VP2, VP6, and VP7 (Laimbacher et al., 2012).
Immunization Route: Intramuscular injection (i.m.)

References

Laimbacher et al., 2012: Laimbacher AS, Esteban LE, Castello AA, Abdusetir Cerfoglio JC, Argüelles MH, Glikmann G, D'Antuono A, Mattion N, Berois M, Arbiza J, Hilbe M, Schraner EM, Seyffert M, Dresch C, Epstein AL, Ackermann M, Fraefel C. HSV-1 amplicon vectors launch the production of heterologous rotavirus-like particles and induce rotavirus-specific immune responses in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2012; 20(9); 1810-1820. [PubMed: 22713696].