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PVSRIPO vaccine vector |
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Vaxvec ID |
79 |
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Vaccine Vector Name |
PVSRIPO vaccine vector |
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Vector VO ID |
VO_0005434
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Advantage |
PVSRIPO has a natural inherent tropism for antigen-presenting cells including dendritic cells and macrophages due to the presence of the CD-155 receptor on their cellular surfaces (Mosaheb et al., 2020). This enables it of inducing CD8+ T-cell mediate immune responses. |
| Related Vaccine(s) |
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| References |
Mosaheb et al., 2020: Mosaheb MM, Dobrikova EY, Brown MC, Yang Y, Cable J, Okada H, Nair SK, Bigner DD, Ashley DM, Gromeier M. Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity. Nature communications. 2020; 11(1); 524. [PubMed: 31988324].
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