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Adenoviral vector |
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Vaxvec ID |
33 |
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Vaccine Vector Name |
Adenoviral vector |
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Vector VO ID |
VO_0000136
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Advantage |
Recombinant, replication-incompetent adenovirus vector vaccines can efficiently generate humoral and cellular immune responses. One of the most popularly studied viral vectors, Adenovirus (Ad) vectors have also demonstrated promising results against filoviruses. First-generation Ad vectors expressing ZEBOV GP have demonstrated 100% protection in NHP against homologous virus challenge. Additionally, it was previously demonstrated that second-generation complex Ad vectors expressing multiple filovirus GP antigens can provide complete protection of rodents against ZEBOV or MARV challenge (Swenson et al., 2008). |
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Disadvantage |
Adenoviral vectors are only capable of carrying a single filovirus GP gene due to restrictions in genome size of first-generation Ad vectors (Swenson et al., 2008). |
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Description |
One of the most popularly studied viral vectors, Adenovirus (Ad) vectors have demonstrated promising results against filoviruses. First-generation Ad vectors expressing ZEBOV GP induced 100% protection in NHP against homologous virus challenge. Additionally, second-generation complex Ad vectors expressing multiple filovirus GP antigens can provide complete protection of rodents against ZEBOV or MARV challenge (Swenson et al., 2008). |
| Related Vaccine(s) |
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| References |
Brown et al., 2014: Brown LJ, Rosatte RC, Fehlner-Gardiner C, Bachmann P, Ellison JA, Jackson FR, Taylor JS, Davies C, Donovan D. Oral vaccination and protection of red foxes (Vulpes vulpes) against rabies using ONRAB, an adenovirus-rabies recombinant vaccine. Vaccine. 2014; 32(8); 984-989. [PubMed: 24374501].
Kim et al., 2014: Kim E, Okada K, Beeler JA, Crim RL, Piedra PA, Gilbert BE, Gambotto A. Development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model. Journal of virology. 2014; 88(9); 5100-5108. [PubMed: 24574396].
Swenson et al., 2008: Swenson DL, Wang D, Luo M, Warfield KL, Woraratanadharm J, Holman DH, Dong JY, Pratt WD. Vaccine to confer to nonhuman primates complete protection against multistrain Ebola and Marburg virus infections. Clinical and vaccine immunology : CVI. 2008; 15(3); 460-467. [PubMed: 18216185].
Xiang et al., 2014: Xiang ZQ, Greenberg L, Ertl HC, Rupprecht CE. Protection of non-human primates against rabies with an adenovirus recombinant vaccine. Virology. 2014; 450-451; 243-249. [PubMed: 24503087].
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