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adeno-associated virus vector |
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Vaxvec ID |
24 |
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Vaccine Vector Name |
adeno-associated virus vector |
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Alternative Names |
AAV |
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Vector VO ID |
VO_0000571
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Description |
There are many subtypes of AAV. In total, there are six serotypes of AAV, including AAV type 1 (AAV-1), have been isolated from primates, and two have been isolated from nonhuman primates; AAV-2, AAV-3, and AAV-5 are from humans, and AAV-6 is from a human adenovirus preparation. AAV-2 is the most characterized primate serotype, since its infectious clone was the first one made |
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| References |
Cwerman-Thibault et al., 2014: Cwerman-Thibault H, Augustin S, Ellouze S, Sahel JA, Corral-Debrinski M. Gene therapy for mitochondrial diseases: Leber Hereditary Optic Neuropathy as the first candidate for a clinical trial. Comptes rendus biologies. 2014; 337(3); 193-206. [PubMed: 24702846].
Dyka et al., 2014: Dyka FM, Boye SL, Chiodo VA, Hauswirth WW, Boye SE. Dual adeno-associated virus vectors result in efficient in vitro and in vivo expression of an oversized gene, MYO7A. Human gene therapy methods. 2014; 25(2); 166-177. [PubMed: 24568220].
Joyeux et al., 2014: Joyeux L, Danzer E, Limberis MP, Zoltick PW, Radu A, Flake AW, Davey MG. In Utero Lung Gene Transfer Using Adeno-Associated Viral and Lentiviral Vectors in Mice. Human gene therapy methods. 2014; ; . [PubMed: 24660751].
Liu et al., 2014: Liu Q, Huang W, Zhang H, Wang Y, Zhao J, Song A, Xie H, Zhao C, Gao D, Wang Y. Neutralizing antibodies against AAV2, AAV5 and AAV8 in healthy and HIV-1-infected subjects in China: implications for gene therapy using AAV vectors. Gene therapy. 2014; ; . [PubMed: 24849042].
Tian et al., 2014: Tian F, Wang L, Arias A, Yang M, Sharifi BG, Shah PK. Comparative Antiatherogenic Effects of Intravenous AAV8- and AAV2-Mediated ApoA-IMilano Gene Transfer in Hypercholesterolemic Mice. Journal of cardiovascular pharmacology and therapeutics. 2014; ; . [PubMed: 24742767].
Weber et al., 2014: Weber ND, Stone D, Sedlak RH, De Silva Feelixge HS, Roychoudhury P, Schiffer JT, Aubert M, Jerome KR. AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication. PloS one. 2014; 9(5); e97579. [PubMed: 24827459].
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