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canarypox viral vector |
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Vaxvec ID |
14 |
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Vaccine Vector Name |
canarypox viral vector |
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Alternative Names |
CaPV |
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Vector VO ID |
VO_0001043
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Function |
This vector has been applied with success to vaccinate against emergent infectious disease and cancer in humans. (Di et al., 2013) |
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Advantage |
In human clinical trials, attenuated canarypox strain was considered to be a highly advanced recombinant poxviral vaccine vector (Di et al., 2013). The canarypox vaccine vector has been successfully employed against cancer in humans and emergent infectious diseases. Canarypox virus is one of the most advanced recombinant poxviral vaccine vectors in human clinical trials. |
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Safety |
The canarypox vaccine vector is pathogenic in some avian species but incapable of effectively infecting humans. This property of its virulence is due to its inability to complete its life cycle and create an particle that is infectious. |
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Description |
Attenuated canarypox strain is part of the poxviridae family. It is classified under the avipoxvirus genera and is one of the highly attenuated vaccinia virus (VACV) strains. It's genome size is approximately 330 kbp and it has about 320 genes. (Di et al., 2013) |
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| References |
Boone et al., 2007: Boone JD, Balasuriya UB, Karaca K, Audonnet JC, Yao J, He L, Nordgren R, Monaco F, Savini G, Gardner IA, Maclachlan NJ. Recombinant canarypox virus vaccine co-expressing genes encoding the VP2 and VP5 outer capsid proteins of bluetongue virus induces high level protection in sheep. Vaccine. 2007; 25(4); 672-678. [PubMed: 17059856].
de et al., 2004: de Bruyn G, Rossini AJ, Chiu YL, Holman D, Elizaga ML, Frey SE, Burke D, Evans TG, Corey L, Keefer MC. Safety profile of recombinant canarypox HIV vaccines. Vaccine. 2004; 22(5-6); 704-713. [PubMed: 14741163].
Di et al., 2013: Di Pilato M, MejÃÂas-Pérez E, Gómez CE, Perdiguero B, Sorzano CO, Esteban M. New vaccinia virus promoter as a potential candidate for future vaccines. The Journal of general virology. 2013; 94(Pt 12); 2771-2776. [PubMed: 24077296].
Guthrie et al., 2009: Guthrie AJ, Quan M, Lourens CW, Audonnet JC, Minke JM, Yao J, He L, Nordgren R, Gardner IA, Maclachlan NJ. Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus. Vaccine. 2009; 27(33); 4434-4438. [PubMed: 19490959].
Walther-Jallow et al., 2001: Walther-Jallow L, Nilsson C, Söderlund J, ten Haaft P, Mäkitalo B, Biberfeld P, Böttiger P, Heeney J, Biberfeld G, Thorstensson R. Cross-protection against mucosal simian immunodeficiency virus (SIVsm) challenge in human immunodeficiency virus type 2-vaccinated cynomolgus monkeys. The Journal of general virology. 2001; 82(Pt 7); 1601-1612. [PubMed: 11413371].
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