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Vaccine Comparison
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pRP-RSV-HSV-1-gB |
rOka-gD2- HSV-2 |
| Vaccine Information |
Vaccine Information |
- Vaccine Ontology ID: VO_0004723
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- gB
gene engineering:
- Type: Recombinant vector construction
- Description: The herpes simplex virus type 1 (HSV-1) glycoprotein B (gB-1) gene, was cloned under control of the Rous sarcoma virus long terminal repeat in the episomal replicating vector pRP-RSV (Manservigi et al., 1990).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: The herpes simplex virus type 1 (HSV-1) glycoprotein B (gB-1) gene, deleted of 639 nucleotides that encode the transmembrane anchor sequence and reconstructed with the extramembrane and intracytoplasmic domains, was cloned under control of the Rous sarcoma virus long terminal repeat in the episomal replicating vector pRP-RSV (Manservigi et al., 1990).
- Immunization Route: Intramuscular injection (i.m.)
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- Vaccine Ontology ID: VO_0004710
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- gD
gene engineering:
- Type: Recombinant vector construction
- Description: The herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) gene was inserted into an intergenic site in the unique short region of the Oka VZV genome (Heineman et al., 1995).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) gene was inserted into an intergenic site in the unique short region of the Oka VZV genome (Heineman et al., 1995).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
References |
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Heineman et al., 1995: Heineman TC, Connelly BL, Bourne N, Stanberry LR, Cohen J. Immunization with recombinant varicella-zoster virus expressing herpes simplex virus type 2 glycoprotein D reduces the severity of genital herpes in guinea pigs. Journal of virology. 1995; 69(12); 8109-8113. [PubMed: 7494331].
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