VIOLIN Logo
VO Banner
Search: for Help
Vaxvec Home
Introduction
Statistics
News and Updates
Vaxvec Vectors
Vaxvec Vaccines
Vaxvec Antigens
VaxvecAg BLAST
Selected Vectors
B. abortus RB51 vector
RSV vaccine vector
SL3261 vaccine vector
VSV vaccine vector
Data Submission
Data Exchange
Data Download
Documentation
FAQs
Disclaimer
Contact Us
UMMS Logo

Vaccine Detail

SL3261-L. donovani
Vaccine Information
  • Vaccine Ontology ID: VO_0004672
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Host Species as Laboratory Animal Model: mouse
  • KMP-11 gene engineering:
    • Type: Recombinant vector construction
    • Description: The sequence encoding cholera toxin B subunit signal peptide was followed by SpeI/BglII sites for in frame directional cloning of ORF of interest fused with downstream sequences coding for a hemagglutinin epitope (HA)-tag and the transporter domain of AIDA (Schroeder et al., 2011)
    • Detailed Gene Information: Click Here.
  • Vector:
  • Preparation: Five chosen antigens were differentially expressed on the surface or in the cytosol of Salmonella typhimurium SL3261. A two-step procedure was developed to select optimal Salmonella vaccine strains for each antigen, based on bacterial fitness and antigen expression levels (Schroeder et al., 2011).
  • Immunization Route: Intramuscular injection (i.m.)
References
Schroeder et al., 2011: Schroeder J, Brown N, Kaye P, Aebischer T. Single dose novel Salmonella vaccine enhances resistance against visceralizing L. major and L. donovani infection in susceptible BALB/c mice. PLoS neglected tropical diseases. 2011; 5(12); e1406. [PubMed: 22216363].