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Vaccine Detail
SL3261-L. donovani |
Vaccine Information |
- Vaccine Ontology ID: VO_0004672
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Host Species as Laboratory Animal Model: mouse
- KMP-11
gene engineering:
- Type: Recombinant vector construction
- Description: The sequence encoding cholera toxin B subunit signal peptide was followed by SpeI/BglII sites for in frame directional cloning of ORF of interest fused with downstream sequences coding for a hemagglutinin epitope (HA)-tag and the transporter domain of AIDA (Schroeder et al., 2011)
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Five chosen antigens were differentially expressed on the surface or in the cytosol of Salmonella typhimurium SL3261. A two-step procedure was developed to select optimal Salmonella vaccine strains for each antigen, based on bacterial fitness and antigen expression levels (Schroeder et al., 2011).
- Immunization Route: Intramuscular injection (i.m.)
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References |
Schroeder et al., 2011: Schroeder J, Brown N, Kaye P, Aebischer T. Single dose novel Salmonella vaccine enhances resistance against visceralizing L. major and L. donovani infection in susceptible BALB/c mice. PLoS neglected tropical diseases. 2011; 5(12); e1406. [PubMed: 22216363].
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