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Vaccine Comparison
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Bordetella pertussis BPZE vectored vaccine |
S. gordonii-PT |
VC-TetC/Tcf |
| Vaccine Information |
Vaccine Information |
Vaccine Information |
- Vaccine Ontology ID: VO_0004608
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: The pertussis toxin gene, which encodes a highly virulent toxin (Mielcarek et al., 2006).
- Vector:
- Vector: Bordetella pertussis BPZE, which is attenuated for 3 different toxins: the pertussis toxin, the dermonecrotic toxin, and the tracheal cytotoxins (Mielcarek et al., 2006).
- Immunization Route: intranasal immunization
- Virulence: The pertussis toxin itself if extremely virulent, but after thorough and careful attenuation, the virulence is basically gone (Mielcarek et al., 2006).
- Description: This is an intranasal vaccine because pathogenic B. pertussis colonizes the respiratory tract of humans. The vaccine itself has been shown to only need one inoculation in order to elicit protection, making it a good candidate to be a vaccine vector for other diseases (Mielcarek et al., 2006).
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- Vaccine Ontology ID: VO_0004670
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: (Lee et al., 1999)
- Immunization Route: Intramuscular injection (i.m.)
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- Product Name: VC expressing B. pertussis TetC/Tcf
- Vaccine Ontology ID: VO_0004781
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- TcfA
gene engineering:
- Type: Recombinant protein preparation
- Description: An attenuated strain of Vibrio cholerae was used as a carrier for the expression of heterologous antigens such as fragment C from tetanus toxin (TetC) and tracheal colonization factor from Bordetella pertussis (Tcf) (Chen et al., 1998).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: An attenuated strain of Vibrio cholerae was used as a carrier for the expression of heterologous antigens such as fragment C from tetanus toxin (TetC) and tracheal colonization factor from Bordetella pertussis (Tcf) (Chen et al., 1998).
- Immunization Route: intranasal immunization
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| References |
References |
References |
Mielcarek et al., 2006: Mielcarek N, Debrie AS, Raze D, Quatannens J, Engle J, Goldman WE, Locht C. Attenuated Bordetella pertussis: new live vaccines for intranasal immunisation. Vaccine. 2006; 24 Suppl 2; S2-54-5. [PubMed: 16823926].
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Lee et al., 1999: Lee SF, March RJ, Halperin SA, Faulkner G, Gao L. Surface expression of a protective recombinant pertussis toxin S1 subunit fragment in Streptococcus gordonii. Infection and immunity. 1999; 67(3); 1511-1516. [PubMed: 10024603].
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Chen et al., 1998: Chen I, Finn TM, Yanqing L, Guoming Q, Rappuoli R, Pizza M. A recombinant live attenuated strain of Vibrio cholerae induces immunity against tetanus toxin and Bordetella pertussis tracheal colonization factor. Infection and immunity. 1998; 66(4); 1648-1653. [PubMed: 9529093].
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