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Vaccine Detail
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Aeromonas hydrophila LSA34 vector vaccine WED/pUTDgap |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004606
- Type: Recombinant vector vaccine
- Status: Research
- Antigen: The protective antigen GAPDH from the fish pathogen A. hydrophila, encoded by the gene gapA34 (Mu et al., 2011).
- Vector:
- Vactor Name:
- VO ID: VO_0001032
- Description: Because E. tarda is commonly a fish pathogen, it is useful as a vector for other pathogens in fish. It has been shown to elicit strong immune responses (Mu et al., 2011).
- Preparation: The gapA34 gene was introduced into P(dps) and transformed into live, attenuated E. tarda strain EIB202 (Mu et al., 2011).
- Immunization Route: Intramuscular injection (i.m.)
- Description: A. hydrophila is a common fish pathogen, so in order to create a vaccine against this pathogen, the gapA34 gene of A. hydrophila was expressed in the bacterial vector E. tarda strain EIB202, and it was shown to increase survival of vaccinated fish (Mu et al., 2011).
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| References |
Mu et al., 2011: Mu W, Guan L, Yan Y, Liu Q, Zhang Y. A novel in vivo inducible expression system in Edwardsiella tarda for potential application in bacterial polyvalence vaccine. Fish & shellfish immunology. 2011; 31(6); 1097-1105. [PubMed: 21964456].
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