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Vaccine Detail
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SL3261 expressing T. spiralis Ag30 |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004605
- Type: Recombinant vector vaccine
- Status: Research
- Antigen: The antigen expressed on S. enterica is the "210-239 amino acid epitope, (designated as Ag30) derived from the 43 kDa glycoprotein of T. spiralis muscle larvae" (Pompa-Mera et al., 2011).
- Vector: Salmonella typhimurium SL3261 vaccine vector
- Preparation: (Pompa-Mera et al., 2011)
- Immunization Route: intranasal immunization
- Description: This vaccine was shown to elicit protective immunity against T. spiralis challenge, in the form of the induction of antigen-specific IgG1 and IL-5 production (Pompa-Mera et al., 2011).
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| References |
Pompa-Mera et al., 2011: Pompa-Mera EN, Yépez-Mulia L, Ocaña-Mondragón A, GarcÃÂa-Zepeda EA, Ortega-Pierres G, González-Bonilla CR. Trichinella spiralis: intranasal immunization with attenuated Salmonella enterica carrying a gp43 antigen-derived 30mer epitope elicits protection in BALB/c mice. Experimental parasitology. 2011; 129(4); 393-401. [PubMed: 21907709].
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