VAEAG: Vaccine Adverse Events Associate with Gene

Record Information
Record ID	7
Pubmed ID	34835092
SNP
Gene ID	3557
Protein ID	P18510
Vaccine Adverse Events	varicella vaccine meningitis
Vaccine	varicella vaccination
Gene Name	IL1RN
Official Symbol	interleukin 1 receptor antagonist [Homo sapiens (human)]
Aliases	DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4
Other Designations	interleukin-1 receptor antagonist protein; IL1 inhibitor; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist
Chromosome	2
Location	2q14.1
Annotation	Chromosome 2 NC_000002.12 (113099360..113134014)
MIM	147679
DNA Sequence	>NC_000002.12:113099360-113134014 Homo sapiens chromosome 2, GRCh38.p14 Primary Assembly AGCTCCCATGCAGCCCACAGCCCTAAAGGCCGGTTTCACTCCCACCATGCCCCACCAACAGCAATGAGTT TACTTCCAGGAAGCTGGTGAGCAGGGCTGAGAACTTGCTCCAGGCTACAAGCCTCCCAGCTGAGAAAACG AGCGAACTCACAGTTCCTCGACTGTCCCATGGAGCCTGCAGTGGCAATCCGCCTCCTTCAAAGGGTCTGT GGACTTTCTCGGCTTTCCTGGTATGTTCCTGTGGAAGTTCTTGGAGCAAAAGTTCACGATGTGGGTCTCC ATACACTGCTCTGTTCATCTGAGTGGGAGCTGCAAATTAGTCCTGCCTCCTATCCGCCATTTTTCCTCAG CATCCTCTTCTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAG GCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCCTTCTCCTGCC TCAGCCTCCCGAGTAGCTGGGACTACAGGCACCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTA GAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCC TCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGACTGGCCCCTCTTCCTTCTTAAAAGCTGGACCA CGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACAAGGTCAGGAGATCAAGACCATCCT GGCTAACATGGTGAAACCCCGTCTCTACTAAAAAAGTACAAAAACAATTAGCCGGGCGTGGTGGCGGGCG CCTGTAGTGCCAGCTACTTGGGAGGCTGAGACAGGAGAATGGCATGAACCTGGGAGGTGGAGCTTGCAGT GAGCCGAGATCGCACCACTGCACTCCAGCCCGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAA AAGGCTGGAAAACTGGAGATTATTTTGAGGCCAGGCGTATTCATGTTCAGGCCAACAGGTACTAGCTGAG CCTTGTGCTAGTCACAAGAGAAGCAGCAAATGACAAGGGGAGGACAGGAGTCTGTCAGGCCAAGCACTGG TCCCTTATGGAGACAAAGAAGAATGAGCCGGACCACAGCTATGAGGTTGACCTAATGGTTTCTCTTGCAG GCACAGTGCCATTGCATTTCCTACAGGGCCCCACTTAGGAGGCACTTCTATCACTCTATCGCACAGATGC AGAAACTGAGGCTCGGAGAGGTTAAGGAACTTATCCCAGTTAGTAAGTGGTGCCGACAAGAATCAAATTT AGACAGTTCTGACAGAAAGCCATGTTTGTAATCACCACATATTCATGCTCCTTCTTAGCACAGGGTGGCT AAAAAGCTCAAACAAGCCAAGATTTAAATACCACAAAGAAGATCCAAGTGACCTGTGAGGAGGAGACTGC CAGTGGATGGGCGATCAGGAAGACTTTGTAGGAGAGGAAAAATATTTTTTTCTCAGTTCTCATAAGTTCT TAGTTGGAATGGGCAGATGAATAAGAGAAAAACAAGCAGATGTTAATTAACATGTATATTTCTTATATAC ATGGGAGACACCCAGGGAATAAGTAGCTTTCAAAGAGGTGGCTTTGAATTCCAGCTTATATAGTGTCTTC AACAAAGAACAGTAAAGTTTTAGAGACATGACAAGGGAATTAAAAAGGACTTTGAGTCTCTAAGAGTAGT GACTTGTGGAAAGGCGAAATGTCAGATAAAGGCTAGTTTGTAAAGCTTGTTAATGTAGATTCCCCTGGTG CCATCTCCAGACTGATAAGAGTCTTAAAGTTGTCTTCGCTGGTTGACCTTTGTCCTCTCTGGTAGACGCA GTGGGGGTGAGGAGTAGGGGTTAGGGTAGCGAGGGGGTTTCCTTCCACCTGTGGGAAGAGGCATTCACAT TTTAAGATTGGGAGCAGGAGGCCTGATGTGATTACAGCTGTGATGTAAAACCGACATTCAATGATATTTT AATATCTCATACCTGTAATCTTTTTAAAAACTTGGGAAAACAACTTATAATTTTTACAAGAACATTAATA AAAATAACAAGTTGCACCTACTATAGCCACTATTTCATAAAAGAAAGGCCATTTTTACATTTCCTCTCCA CTCAGTGAGCATGATCTCAGAAGAAAGGACTGCCTTTCTCAAGAATGAAGAGTTAACAATAGCATCCCAA CATATTTAAATATCAAGCCCTGGGCTCTCGATTTTCTAATTTAATTTAGCTCATCATTAAAACTGGCACT GGTCTAAGGACCAACATGTAGAAACCACCGCTCTGAAAGATCTGGCAGTAGCATAGAAGGCAGATTGGAG CTGGGGAAGAGAGACTTTTTTATTCTTTTTTTATTTTTATTTTTTGAGATGGAGTTTCTCTCTTGTTACC CAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCCAGTTCAAGTGATTCTCCT GCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGTGCGTTATCACACCCGGCTAATTTTGTATTTTTAGT AGAGACAGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGAACTCAGGTGATCTGCCCACCTCG GTCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCCGCCCGAGACTTTTTTTCTTAAGGAGA TTGTCTTAGTCACCTCAGACTGCCATAACAAAATACCACAGGCTGGGTGGCTTAACCAACAGGAAGAATG TATTTGCTCCCAGTTCTGGAGGCTGTGATCAAGTCTCAGATCATCCACTTGCTGGCTGGCAGACAGCTAC CTTCTCACTGTGGCCTTTCCTTGGTGTCTGTGCAGGCACGGGGACAGTGAGAGCTCTCTGGTGTCTCTAC CTCTTCTTATAAGGACACCAATTCTATTGTGTTAGGGCCCCACCCTTATTTAACCTCAATTACTTTCTTA TAGGCTCTATCTTCAAATACAGCCACACTGGGAGTTAGGACTTTGATATGTGGATTGTGGAGGGATTCAG TTCACACAGAGCTATTGCAATGGTTTGGACAAGCAGCTCTAATTGGGGAAGGGGGAAGCCTGTAGGCATG GGAAGGAGAGGTCAGGCGTGTCACGTGCGTCTGTGTGAAAAGACCACCAAACAGGCTTTGTGTGAGCAAC AAGGCTGTTTATTTCACCTGGGTGCAGGTGGGCTGAGTCTGAAAGAGAGTCAGCGAAGGGAGATGGGGTG GGGAGGTTTTATAGGATTTGGGTAGGTAGTGGAAAATTACAGTCAAAGGGGGTTTCTCTCTTTGGGCAGG CGTGGGGGTCACAAGGTGCTCAGTGGGGGAGGTTCTGAGCCAGGAAAAGGAATTTCACAAGGTTAATCGC TCAGTTAAGGTGGGGCAGGAATAAATCACAATGGTGGAATGTCATCAGTTAAGGCAGGAACTGGCCATTT TCACTTCTTTTGTGATTCTTCACTTGCTTCAGGCCATCTGGATGTATATGTGCAGGTCACAGGGCATACA TTGGCTTAGCTTGGGCTCAGAGGCCTGACAAGGCACAGAAGGAGCTGGGATAGAGGTGCAAAGTACTCAT GCTGACCTGACATCCCATGCCCACGGCAGACATGACTACTTGATCGGACAATACTTTCTTGGAATCAAAG ACACAACTTCACAGTCCTCAGCATCATAGTTCAGGCAGCCTGTATCAGTAGATCAGAGTGGGCACATGGC CTGGTGCTATCACTCCATCCTGTGAGGGGAGATGGGATTGGAATGGAGGTGGAGGAGTCACAGGTGGTCC TGATATCACAGGCCTGGGAGTCTGAAAGAAGTGCAGTAGGTAGTATTATGGCCCTCAAAGACATCTGTGT CCTACTGTCTAGAGTCAATTAAAGTGTTACCTAACATAGAAAAAAGGATTTTGCAGGTGGGATTAAACTA AGGATCTCAAGATAGAAAGACTCTCCTGGAGTATCCAGTTGTGTCCAATGTAAGAACAAGCGTTCTCAAA ATAGGGACACAGGAGATTGAATTGCAAAGGAGATGTGCTGATAAACGGAGAGGTTGGAGTGATGCCGCCA TGAGGCAAGGAATGTGGGTGGCCTCTAGCAGCTAGCAATGATTCGGAAATGGATTCTCCCCCAGAGTCCA GAAAGATCACAGCAGTGCTGACACCTTGATTTGAGCCCAGTGTCACCTCTGTCAGACTTCTGCCCTATAG AACTGTAAGAGGATAAATTTGTGTTTTAAGGCACAAAGTTTATGGTAATTTGTTATAGCAGCAATGGGAA ACTAATACAAGAAGGGTTGTGTTATCAACAGAAATACAGCAATCAGAAGAAAGATGGTTGGGGAGAGCAG AGGGTGGGGTGGGAAGGTGATGGATTCTGTTTGGGACATTCTGGGTGTCATATGAATATTATTGGGGAAC TGTCCATCAAAAGCTCAGACTTCAAAGAAAGAAAGGAAGGAGCAACAATATTTTGAAAGGGAGAAAGTAG GTAATATTCAATATGTGTTGAGTACCTACAAGGTTTTTAGTTCTTTCACCAAGTTATTTTATTTAATTTT TATGGCATCAAGGGGTGTTTTTTTTTTTTCTTAAACCAAATTTTCTCAGTTAAGCATCCCATGTAAGTGG CCAGGGGTTAAGAGATGTGACTAAGACTAGACAGAGTGATTTTCATCATTACATGGTACTATGGTTCTAC TGAAGCACTGAGGAAGGAAGTCAAGAGAGTTCCTGAGAAATGTCTGGAGTCTTAGTAACATGCAAAGTGA GGCAGAGGTATTGTCAGTGTTAGCTGGTCACTTTGAAAGGTTAGAGGTAAATAAAGTTCAGGGCAATGGT ACTTGGAGAGGAGTGAATCTTTGGTAACCTGGAGGAGATGCTTCTCAGAGGAAAATTTCTTCACAGCATG AAGTCACCAGCTCTAAGACTAGTGGGTGTTCTGGGGGATGTTAGCAGTGACTCACTGACTGTTGGCCCAG TGAGGGGAGGGATGAAAGGCTGGGTAGTGGGTAGAGAATCTGACTCCTCCTGCCCCCACATGTCTATTCC TGGGCCTTCTCATGGTGGGGGCAAAAGGTATGCAAAGGGATTTCCGCAGTGTCTGAGTGCTCCCAGGAGA CGGAAAAGTAACTGATGACTTGGAGTTGGAGTCTTGTTGGCTCAGGCAGCTGGGGCGTTTTGGGATTTCA ACACCTCCCTTTAGTTTCTATGTATGGTGCTGAGCAAGTAGTCAAAGACTTTGGTCTTGCTTTACCCCAG TAGCCCACAAGCCTGAGTACATGGCTAACATTTATTGGGCACTTAGTGTGTGCCAAAGAGCTTTATGAGA CAGGTTCTTTTTGAGTCCCATTATACTGATAATGGGACTGATAAGAAACAGAAGGTCAGAAAGGCCCAGT AACTTGGGCAAGGTCATGTAGCTAGTAAGTGGTCCAGCTGAAATTTAAAACCAGGTTTATCCAACTCCAA ATCCCACATCTGATTTATTTTGCCATGAATTAAAACATAGTTCTGATTTTGAGAAACTCCCAGTCCCAGT GGGAAAACAGATGGAATCACAAATTACCATAACACAGTGTAGTGATGTAGATATAAAAACAAAGACATGG GAACCCTGAAAGGAAGTTGTAACACCAATAGAGGAATGCACGGAGGAGATCTTTCAGAGGAGGTAGCCTC GTAGCTGGGCTCAGGGGTGGATGAGTTTCTGGCTAGAAGCGCATTGTGGGTAGAGGGAGAACATATATAG AAAGGCATGAAGATGGTGGACATGTTTGGAAAGAGTGAGTACTAGACTGATGAACACGATGAGTCAGGAG CTTATGACGTCAGGGGCTACTGCTAGCCTAGCTAATGACTGAAGATTCTGTGAAAAGAAAACCCTAACAT TTCCAGCTGAGTACTAGGGCCATGGTGATTATATATCATCTCTCATGACAACACAAATGTTTGGGCTTAC TTATCATCCTGCTCAGTAATCATTATGTCACTCATTAAAGATGTATCAGGGTAAATTTTAGGTGAGAATT GATTAGAAATGTAAACTCTATATATGTAGTTACAGGCTTCACAGTTTGCCACTCAAACAATATGGTCATC CAATCATGAGGCACAACCTTCTGCTCAGAACTTTTTTATAATTGGGAGAAAGTGACATCCGAGTTCCATC TCTTCTGAGAACTGTGCAGCTCAGAAATCTTCTTCCCTTTTTTGATCCCCCAGTTGGGTGAGATGACATT AACAGTGTGTTATAAGCACTTTTCATGTTTACTACCCCATATTCAAAATTAAGCATTTCAAACAACTGTA TAATTGTCTATAAATGTAGCATTATTAGTTAATTTTCCTTTTAACACATTGAGGTTACCTCTAATGTTTT GCTATTTTTAACTATGTTGAAATAATCATGTGGTTTTTATTCTTTGAATTATTTTATATTGTAATGTTCC CTGAAATGAAATTAGTTGATCAAAAGATGAGTAATCTTTTCATGACTTTTGATACATGTCACTCAATCAC CTTCTGGAAGAGTTGGAACAAGAGCCTATTGCTGGCATCCCATTTCATAGCCATCTCACCAATGTTGGAA AATGGGCTTTTCCTATTTTCTGCTAATTCATTAGTTGTTAATGGCTTATTTTAACTATTAATCCCTTGTT ATTGATGAAAGTTAAGCATTTTCTGTATTTTTATTTTCTGTCTAAATTCTACTTTTTGCACAATTTCCTT TGCTCACTTCTTCACTGGAATTTAGTATTTTTCTTTCCAATTTGTATGACTCCAAAATCAGTGATAAAAT AAGCAAAGGGTCTTTCTTAGAGGCTAAACAAGGGAATGAATAAGGAACAAGAACAGCAAAGGGATAGTGA ATAAAGATACAAAATAATAACTTATTTTTATTTTTGAAGCTTTCCCCAGGCAGTAATTCTTGACCTTTTT AAGATTATAAATTATTTTGAGATATGCATTCTTATCCTCAAAATGAATTAGTACATAAAATTTAAATGGG TTGATAGATCCCCTGAAGTGTATCCACAAAATGCTCTCAGGTTAAGCAACATTGTTCTATAATAACTGCT TTAACCAAAATGTTTAATTATTGCTTGTGTTTACCTGTCCTAGCAAAGAGCTAATTGTTAAATTTTGTGT TAGAGGGTCAATATTATAAATAACTTAATGTGGCCTCTCTTTCCTTTCCTTTTTTTGAGAGTTTTGAGGC TATCACTAAGTGGGCTTTAGAGTACCAGGTGGGAATCTGACCTCACTGCTCAAACTTTCAACTTCAGGCA TGAAGTGGTCCCAGTGATGTGGGAACCTCAGAGTCTAAAACAAAAATAGTAGACTGAGGCCCTCAGAAAC CAGACTTATCAGATTCAGAATTTAATATAACTATGTTTGAAAGATTTAAAGAAAATAAATCAAATTAAAA AGTGAGCAAGAAGCAAGAATAACAAATGAACTGGCATATTTGAGAAAGAATTTTGAGCTTTTAGAAATAA TACATACAGTTATTGAAGTAAAAACTCAAGTCAATAGGTTTAAACAGCAAAATGAATATAGTTAAAGAAA ACTATTGTGCTGAAAGATTTAAAAAACTATTACACAGAATGCAAAATGATGAAATAGGGTAATTTAATAT ATGGCAGATATGTTAAGACACTATGAGGATAGTATGAGAAGACCTGATAGACATCTAATCACAGCACCTT AAGGTGAAAATAGAGAGAGTGCACCAATATTGAGGAGTTAATGTCTGAGACTATTCCAGAACTGATAAAT AGATGAATCTACAGATCTCAGAAACACAGCTTTTACAAAGGATAAATGAAGAGAAATTCACCAGAGATAC ATTGTAATGAATCTGTAAATCACCAAAGCTAAAGATATTATTTCACAAGTGGAATGACAGCTGACTTCTC AACAACAACGAAAGCAAGGAGACAGTTGAAAGACATCTTGAAAATGGTGAGAGAAAAACTAACTGTTAAT ATAAAATTGTGTACCTATCAAAAATATCTTTTGGCCAGGCGTGGTGGCTCACGCCTATAATCCTAGCACT TTGGGAAGCCAAGGAACGTGGATCACTTGAGGTCAGGAGTTTGAGACCGTCCTGGCCAACATGGTGAAAC CCCATCTCTACTAAAAATACAAAAAAAAAAAAAAATAGCCATGTGTGGTGGTGTGCACCTGTAATCCCAG CTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTAGAGGTTGCAGTGAGCTGAGATCAT GCTGCTGCACTCCAGTCTGGGTGACAGAGTGAGACTGCCTCAAAACCAAACCAAACCAAACCAAACCAAT CTTTCAAGAAGTACACCATAAAGACATTTCTGGATAAACAGTGAATGAGATTACTTCCTAAACGAATATG TAAGGATGTTTCTTTTTAAAATTTTTTTTGGGTGTATTCATCACCTCAAGCATTTATTCTTTTGTGTTGT TACAACTGATAAGAATATCTAAGGATGTTTCAAAAGGAAGAAAAATGATCCCTAAAGTCTGGTATATTAG TTTCTTATTAGTTGCTCTAAGAAATTACTGCAAACTTAGTGGCTTTAAAAAACACGAAATTATCTTTCAG TTCTGTAGGTCAGAAATTTAACCTCCTGATTTCTGGTCAGAAGTCTTACTGGGCTAAAATCAGGGTATCA GCAGGGCTGCTGGAGGCTCTGGAGATGATGTTTCTCTAATTTCTAGAGGCATTTGCATTCCTTAGCTAGT GGCTTCTTCCCACATCTTCAAAGCTAACAGTGGCAGTCGAGTCCTTCTCTTATCTTTTTTTTTTGGGGGG GGTTATAAATTTTTTTTATTATTATTATACTTTAAGTTTTAGGGTACATGTGCACAACGTGCAGGTTTGT TACATATGTATACATGTGCCACATTGGTGTGCTGCACCCATTAACTCATCATTTAGCATTAGGTATATCT CCTAATGCTATCCGTCCCCCCTCCCCCACCCCACAACAGTCCCCAGTGTGCGATGTTCCCCTTCCCTTCT CTTATCTTATCACTCTGACCTCTTCTGCCTCCTTTCTCTACTTTTAAGGACCCTTGTGATTAGATTGGGT CCACCTAAATAATCCAGGATAATCTCTTTATTTTAAGGTTAGCTGATTAGCAACCTCAATTCCATCTGTA ACCTTAATTTCTTTTTTGCCATGTAACCTAACATAGTCACAGGCCCAAGGGAATAATAGGATGTGGGAAT TGCGGGTGGTGGAGTAGGGGCATTATTCTGCTTACCACAGGGGACCTTGGATGTCAGTAAAAAATGGTGA GGAAGAAAACAGGAAACGTAGAATAATCTAAACAAATCTTTGAAAAATAAGTCGAAATGTGGGGTTAGAA AAAGGGCAGAACTAAAATGTTAAGACAAATTAAAATGTTAAGCCTATAAGTTGAGAGGGAGATGATCAAG GTTAAAAATACTCATAAATCATATTTTTTTGGGTAGGGGGTTAGATATTTATTAATTTTAGACCCTGAGA AGTAAAATAGTCATGACAAAAATTTAATAGTAACCACTAAAACAAGAGAAACAGAGTATATAACTTCTAA ATCAATATGGGAAGGGGAATGGAATAAGAAAACAATAGCAACCACCAACACCCCACCCAAAATAAATAAT AAGGTGAGAGAGAAAAAGAAGCATTGAAAAGGGGCTAAAATAAAATAAAAAATTAAGTCATGCCCGTAAT CCCAGCACTTTGAGAGGCCAAGATGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACA TGGGGAAACCCCATCTCTACTAAAAATTCAAAATTAGCTGGGTGTGGGGGTGCATGCCTGTAATCCCAGC TACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGTGGTGAGCAGAGATTGTG CCATTGCATTCCAGCCTGGGCAGCAAGAGCGAAACGCCATCTAAAAAAAAAAAAAAAAAAATTAAGATAG TAAAACAAATCCAAATACATTAAAGATTACAAAAAATGAAAATGAACTAAACTTCCTAGTTGAAAGACAT ATTGTCAGATTGGATTTTAAAATCTGGCAATGATATTTCCAGGACACAGTCCTAAAATATTAAACACAGA AAAGTTGAAAGTAAAGGGATGGAAGAACACAGTCAAACTAACTAGAAGAGAGCTGGGTTCACCCTTTTAT ATCAGAGCAGAATTTCACTGAGAAAACACTAACAGGAAGGGGGAAAGGCACAACATAGTGATGAAGCACT TAATTCTCAACAAATGTATGACACTTCTAAACTATTATGACTGCAAAAAAAAAAAAAACCTCAGCATATA TAAAATTTTGGAAGAGCCATGGCTATCAGCTGACATGCACTTACCATATTTGCATTGTCCTACTACAAAC TTTACCCATATGACCAAGGTGCTGTCTTCATCCCCATTTTACAGATGGGGAAATTTCCCCATAGAGAAAA AGATTTGGGCCATGCCTTGGTTTCTTCTTGACTCTGCTTCCTGCTGATTGATCCTCACACCTCACCTGGA GACCTACTTCACATTATCCATCAGGATGAGAACTGGTGTGCCTTTACCAAAGGACCACAGTCACCTTCAA AACGTGTTTAGATAGATCTGGATGGAGACTTATGTGGTTGCAGATGAAAAAAAAGTCCCCATGGTATATC TGACTCCATGTCATTCACTGCATGAACACTCACACACATGCACACGTACACAGGCAAACACAATCCTGTT CTGGTCCGGCAGTAGTGCCAACACTCAAATCCCAGGTCCTACTCTGAAGCCTTTGAGGAAACCATTGTCA TTCTGGGGTTTATGGGAATATTTCTTCTTGGTGCCCCTTGTTCCTCACAGAAGCTTTTTTTCTGTGCTGT GGGCTTGCTATCCTAGCTTTCCAAGCTATCCTAGTTTTGCAAATTTCTCTGATCAATCACATCAGGTTCT TGGATCATCCCAAAATTAAAGAGGTACGTTTTGCTGCAAGAGACAAAGACATTCACCTCTCACACAGTTT GAATTCCTGGGTAGAAACAGATTTCAATGCTGGCCAGCCTCTGTAGCTCCCAGTGCCCCCTCAATTATGA CTCCCGAGGCATTGGAGCAGGATCCTCACCTTGCGCAAAGATAATTAGGTGTGCTGAAGAAAGCCAGACA CTGCTCTTTCTTAGCTCTGCATCCTTAAAAAGTTACCACTACTCCTTCTCTTTGAACCTTTGACTTGTCA ATGGTAAAGTGCCTATGATTCTTAAAGGGATAAAAACGCAACCTATATAAAGCACCTGGCATAGTGCCTG GCACAGGTGGGTGTTTAACAAATGTTAACTCCTTTCTATCCCACTGTGGGTGTCCATATCCTCTTGGGTA GGCTGCCTCTGGTTTCCATTGTGTCATCAGAGCCATACTAAATCGATGTGTTGGACATGGATCCCAAGAA CTAATTTCTGGAATGAGTTATGCCTACCAACTTCCCTGATACTTACTTCTGTCTCTCCATTTATCAAATG GAAATGTTTGCATTTGGCCTCTGCCAGTTGGAGTAACCAAAAGGCTTAGAGGTTTTGGAGAGGTCCTACA CTGCCATCTGTTTGACCACATACTGCCTTTCACGTGTAATAAGCATTGTTTCTTACATTTGTCTAGGAAT TAGCAGTTCACAAAGCACATTCGCATATAAGGGCTTGTTTTGAATTGATCTTGGCAGCAATTCTATGAGA CAAGTAAAAGGTAGGTCAAGCATTATAATCCTCATTTTAAATCTGGGAAAACTGAATCTCAAAAAGGTTG AAAGACTTGTCTAGGGGACAGTGTGTGGGTAAATGAGAAGTTAAGATTTGCTGAACTGGCATTTCCTGAC TACATATCTAGTGTTTATTTATGGAGAAGGCACTACGGTGGCCAAGTGGCTCAGAGTCACACAGCTCTGT GCCTCAGTTTATTTGTCTGTAAAATGAAGATAATAATATATTCTGAATACTGTTGTGGAATTTCATTGAG ATAGTTCACATAATGGCATGGATACTGTAGTACACCGCCTAGATTCACAACCCCACGACTATCCATGAGA ATGGCCCATAGCTCAAGAGGTCACATTCTTTCCCCAGGTGAAGCCCGCATCCAATGACTGCTCAGTGTGG GTATATAAAGGCCTGGCTCCCTTGCCAGTGCCACCCTACCTCCTGGCGAATGGACTGAGGCTTGCATTAT GACTGCATTGCAGCTCAACTGTTCTTTCCATTCAGTCTTTCCTTTACACTCACACAGGTGAGGACCCAGC CATTAAATGCCTCACATGATAACCTCTATTGCATGCTAGGCTTCGTGTGCACACACAAAAACCATCCTCT ATCAGTCAGGTCCCTTACTTGCAGAGGCAAAGAGGCCAGTCTGGGTTAGATGTGCACCCTGTTTTTACAA CAGAACGAGACAAACAGGTCCTCCTTAGGTGTAAGTTCATGGCCTTGGCCCCACCCCTGAAACTCAGCCA TCTGAGACAGTTTTAGGCCTGAGGCAACCCCAGACTTTGGGTTGTTGTTTGCTGGGCACAGCCTCCTTTT GCCAATGTTGCAATCCTTTGTAAGAGACCACAGGTTGATCACCCGTTCCTGTTACTGAGCACAGAGAGGT TTGTAGGCCAGTCTCTCCAGGAATTCTGACGCACTGCAAAATCCCATGGTCTGAATGCTTCTACCTTCCC TGTGAAAGCCCCTGGCCTCAGAAAAGGAAGCTGGTTTAAGTGACCAACATTTGGGGCGGAGCTTCCGAGG GCCCAGCCACCGTGTTACATGCAACACTCAACAGAGATATTCTTTGGCTAGAGTTGTTTTTCTGGGTATA GGACCCTATAATTAAAATCAGCTCTCCAACTTCCCTTCCTCCAAAAAGTATACAATGTAAGGAGGAAAAT GCAAATTGAAAAGTTGCTAGTCCTTCCCGCCAGAATGCCACCTCAAGCCTCCCCTGCAGGAAGTTCTGGA GTCCCCAACTCTGCCCCAAGCCTGAGGCCCTTGATAAGGTAAAGGGATGTGAGTGTGGAGGCCGGAGCCC CCCTCGCCCTGTAGGCTGCTCCCCTTGCTTTTCCCTTTGAATGTTACAGTTTAGTTCTGTGACTTACTTA TAATTGCCTGAATTCCCCGCCCACGCTTTCTCTTACTTTGGGGCTTCTCACCGTTCCTCTTCCTCCATCT TCCTCCTCTGACCCCACTCCCAAGCCTGAATGGGGTGTTCCTCTTCCGTGCTCCCACAAAACCCTGTGCC TCTTTCATCGTTGCATATATTATGCTGTAATGTAGTTTTCTGGAGGTGTGAAGACTATGAATCCTATGAA GACAAATACACACCTACCTTGCTGACCGTTGTATCCTCAGAATCTAATACTGCACTTGGCACACAGTGGT TGGGAGTAAATATTCATGAGGCAAACACACAGGAAGGACTCTTTTGTTATGGTTGTTTGTTGTTGTTGCA AGTAACATAACCCCACCTTGATCTAGCTGACTGACGGCTCTACCACCTTGTCTTTTGCAGCACAAGAGGA ATAGGAACTGCACCTCTTCCTTCAGTTTCAGCTTGAATAATATCAGGAAGATTCGTATCGGTCTGAGTTG GGTCACGTACCCGACGTGCTATAGCTGAGGATGGGGTAAGCTGATTGGAGTTTGCAACACTGTTCACATA GCCAAGATATGGAAAGAACCTAAATGTCAACTGGTGGATGAATGGATAAAGAAATTGTGGTATATACATA CACTGGAATATTATTCAACCTTAAAAAGAAGGAAATCCTAACATTTGTGACAACATGGATGGACCTGGAG GGAATTATGCTGAGTGAAATAAGACAGACACAAAAAGACATTTCTTGCAGGAGCTCACTTATATGTGGAA TCTAAAATAGTCAAGCTTAAAGAAGAGAGTAGACTACTGGTTGTCAGGAGCAGGAGAAAAGTGGAAATGA AGAGGTGATAGTTAAAGGGTACAAAGTTTCAGTTATACAAGATAAATAAGTTCTGGAGGTTTACTATTAA TATATCACATAGTACCTATAAGTAACAATACTGTATTGTATACTTAAAATTGCTAAGAGGGTATATCTTA TATGTTCTTACCAATAATAATAATAATGGTAATAATTAAGGGGCAGGAGGACACTTCAAAAGGTGATGGA TATGTTTATGGCCTTGATGGTGGTGATGGTTTCATGAGAGTATACTTATCCCCAAACTAATTGAGATGTA AATATTAAATATGTACAGCTTTTTGTATGTCAATCGTACCTCAGTAAAGTAGTTTAAAAATGGTTGGACT GAGAAAAGGAGGAGCTGCTCAGCAACATGAGGCTGGGTGCTGGGCAGACAAAACCTCACACATGCATTAC TGAACCCACGGACTCATGTCTGTGAGCTTTGTGGCTGTGGATGCACCATGCCAATGTAGTCAAGGATTCT TCAATGTGTACCTTACTGGATTAGTTCCCTCTGTTTATTTGTATTGACTCCTCAGTTCCCTTATGGGTTG CTTGTTGGCTCTTGTGGAATTATTTAAGTAAGGCTTTGGTTGCAGGAGTCAGACATGCTTAAGCTGGTTT TGGCTGTAATGGGGAATTTGTGAGATGTGACACAGTGACAGGAAGTGCAGCCAGACGTTGTGAGAGGCAG TAACTGGGAATAGGAAAGTTATGAGAAGTTAAGGCAGTAGTAATTGTTTCTCTATCGAAGGCCATAATGT TATCATTCCTGCCTCTATCTGTTTGCTTGTTCTTCTCTCTCAGCAGAATGGTCTTCTCTGCTTCTCTGTG CACCTGCAGAAGGTGACCACCCTAAGGCTTATGGATTCAGGAGTCCTCAGTTTGAGAGCAGTTACCAAAT GCCTCGCCCCTGTGAACTCTAGTCCCAGTTTCTTATTCCTGGTACTGGCTTAGTTTGAGGCAGCTGCCCA CCGTTAAGTCCAGTGAGCCATGGCCTGGGGACAAGGTCAGGTACATGTGTAATCAGCTGGGTCTGTGAGT TGTGGTGGTGGCGATGGAGGTAGCTCCCAGAAAAATGGATTACAGGTTAAGAAGAGTCTATATATCTTGA CCACATTTGATGTGACTTGGAAGTTTCAATGTGTGACCACTTACAAAGTTATGATCAGGTGTCTCATTTA TTTATGGTGATGTATGAGTCCGTGTGTGAGTGTGTGTGTGTCTGTGTTTGTGTGTGTGTGTGAGAGAGAG AGAGAGAATGAGAATATGAGTGGTGGTTTCCCATTTATTTTTCTATGGGCCAAATCCTGGGCTATGAGCT GGAGATATAAGAGTAAACAAAATAGACACGGTGCTTGCTGTGACCTGCCCTGGGAGACAGATATTACACG GAGGATCACATAAATGCAGAGTCTGAGCTGAGGTCTTAAGGGTGAGGATAAGTAACTAGTCAGTGGAGCA GGGGAGGGAAGGGTGTTCCATGCCTGTGTCAAGGTCCTGAGGTGAGAGAAAGAGGTGAATTTGAGGAACC AAAAGGAGTTCAGGGAACAAGAGGGGCTGTTTCACAAGCTGAGTCTGGAAGCTGAGCAGGCTGAGCAGAT TCTTAGGAACTCTGCAAAAACTTAAGGGCTTGTCTATGACCGTAAACAACTACGGTCGTAGATAAACAAG TTGGCAAACAACTCAAGGATTTACAGTCATCAGAATTGTAAAACTGATCCCATGTATTTTCAAACCTCAA ATCCCTTGCTCTGACCTTGTGTGTCTAAGCTAGAAGGAAGCAGGATGCACCTCTCCCCTGGCTGGAATGA AGGGATTCACCCAAGCTCTCAGTCTTCTCACGGCATCCAGGGCCCCCCTGCTTGTGTGTGGTCTAGATTT CCATTCCCATAGTAGGAATTCCTTTGGGAGCCTTGGGGTCTCTCCTGCTAGAGGGCTTCACCTGTGACTG TCTCAATTCAAGGGAGGGGTTCTAATAACATTAAACCTCAATATCTTGCTCCTCCATTCCTGATGCCTCC CTTTCCTTCTACCCTTCCCCTACCTCCTTCTTTCCTATGCCACAGGCTGGCAGGTTAGTGCCAGAGCAAG TGGCCAGTCACCATCATTGGGGTTGTGGATCCTCAGGGTTCTTCAGAAGCCCCTTCACCATGATCAAGAG TCTCCAGTCACTCAGAATTCCACGGTTCCCAAATGCCAGCTCTCCCACTACTCCCAGCGTTCTCCATCTC TGGGATGTTGGGCTCCAGGCTTCTCAGATGCACTGAGTACCCTAGGCTAAGCCACTGATCCATCAGAACT TCATAGCCTGAGAGGAGAGGGAGACAGGCTTGCAAAGGAGAGTTCTGACTAGACACTGGGGTGCTACAGA TGCCCGTAAGTTGTCCCTTTACCCTCGATGTCCCCAGTGTTGGGACCACCTGGGAATGCCCAGCCTTGTG TGCTGATTGACTTGTAGTCCCCTGGCCCTGACTGGAAGCCTAGTTTTCTCTCTCATGACCAGCTAGGCCC CTAGCTCCCCAGGGAAGAAATCCAATCTATTTCCTCTGATAGTAATGGCTAATACTTAAATAATGCCAAC CACATGCCAAGCACTTTACAGTTGTTAGCCCAGTCTTCACAAGCACCTTGTGAGGTGGGCAAGAGTCTTA TCTTACTCTCATTTTATAGATGTGGCCCAGGATCCCACAGCTATAGTTCATGGTGCTGGGATTTGAACCT CTGGCCACCAGAGCCCACCTTAATGTGTCCTCCTCCTGTTGTCATAACAGAAAAGTACAACACCATGATG ACACATCAGGCTATCCTGGCAGGTTCCCAGGCTGCCCCAATGCCCAACTTTCTAGGTTTACAAAGTTGAC ATTTACGAAGTTTCCAGGTTTACAAATCTAGTTTCTGATTCTTTAGTCAGCAGGAATTTCTCTACAAAAG CTGCTTCGAAAATTTCCAGCCAAACCTTACACACCTTGGCATTACATCTTGGTGAGCCAAGGCGGAAGAG AACAGGAAGTGAAGGCCCCATGGGAAGTCCCTGCGGTCGGGAGCACCCAGGCGGGGCGGGGGGTGGGGGG CTTTCCTGTGGCCGGCTCCCTGCCCCTCCCACCCCCATTCAGGCCCTGTGAGTTGAATGAAGAGACCCTG GGAATGAGTCCAGGTCTGCAGGGTTAGAGGAAATTGAAGGCCCTTACCAGATCCCTGTTGAGAAGTTTAT GAATTATGAGCCCTTCTGCAAATGAGAGGGTTCTTCCCTGTCAGGAGGGACAGATTGTAGGTGGCAAGAT TGGTGGCAGCCAGTAGGCTGGTCTGCTCCTTCCTCTCTATTTCATATGTGTATGAAGGCATTACCTGCAG CAAGGGCCTGTGTAAATGCATGTGATTTACAGAGCATTTTATGTACTGCGTGTCATTCATGCTTCCGGTG AGCCCTAAGTCTAAGATAGGGCAGATAGCATCAGGTCCATTTTGCAGCTGTCAAAATGAGGTCTGAAGGG CAGAAGTGGTGTGCCCACACACACACAACTGGTTGGCTGCAGACCTGGGGACTAGACCCGGGACTTCGTC CTGCCCAGGGGTCTCTTGCCACTGCTCCCCATCAACTTGGATGGCTTTAAGCATTTGTGAGTTGTCTGCT CCCTGATGGCAGAATGCAGAGACATGAAGCTACAAGCAGGTTCGCTCCCAACGGCAAAAAGGAGGAGGGG TGTTCAGAACATCAGGTGCTTCTAGAGAAAGCAGGGAGAGAGTATCTGGCCTTGTGGACAATGTCACGGC AGAGGCCAGGTATAGGGCATGGGGGTAACTGGAAGCGGGATGGACCCTGTTATTCCCTAAGACATGGCTT CCACGTAGTGCTCAAACAAGGCCTTTGCCCTTGCTGTTCCCTCCACCTGGAATATTCTTCCCCTTCCTTG ACATTGCTCAGGTCTCCACTCTTATGTCACCCTCTCAGAGAGGGCTTCCCTGGCCACTTTCCCTAAAATA GCCACCCACTCCTAGGTCCCTCAAAAGCATATCCTGCTTTGGATTTTCCCTATAGCAATATGCCCTATGA AGTTATTTTATTTGCTAACTTGTTTCTTGTCTGTTTTCCTTTGTTAGAGCGTTGGGGACCTTGTCTGGCT TGTTCCCAATGCCTGGAAGAGTGCCTGGCACACAGGATTAAGCCAACACATATGTTTTGAATGAATGTGT GCACACATGCATGAGCTGGCGGCAGTCGGGGTTGGGGTAAGCACGAAGGCCCAGCTCAGTTCTCTGCATG TGACCTCCCATCTTACGCAGATAAGAACCAGTTTGGTTTCTGCTAGCCTGAGTCACCCTCCTGGAAACTG GGCCTGCTTGGCATCAAGTCAGCCATCAGCCGGCCCATCTCCTCATGCTGGCCAACCCTCTGTGAGTGTG TGGGAGGGGAGGCTGGGCTCCTCCTTGTACTCTCTGAGGTGCTCTGGAAGGAGGGGCAGCTCCACCCTGG GAGGGACTGTGGCCCAGGTACTGCCCGGGTGCTACTTTATGGGCAGCAGCTCAGTTGAGTTAGAGTCTGG AAGACCTCAGAAGACCTCCTGTCCTATGAGGCCCTCCCCATGGCTTTAGGTAAGCTCCTTCCACTCTCAT TTTTTCACCTGAGAAATGAGAGAGGAAAATGTCTACAATTGGTGTTTATCAAATGCTTTCAGGCTCTGGT GAGCAAGCGTCCAGGAAAATGTCAAGCGCATGGAGCTCCAGGCCTGTCTGGGGGATCTGGGCACGGGGAG GCATCCATGGGAGACCATGCAGGCACTCTGAGGCAGGGGCTGCAAGCCTAGTGCCTGCTGGGGCAGCAGG TGAACAGAGAGGTGTAACTGCTGTGACAGAAGTCATGGAGTCCTTGGAGTGTGAGGGTCATTTTCCACTG TTGATAGAATAGGGAAATTGGTGAAATAGCCCTGTTAAATGAGAGAAAGAACAGTGTGAGCTCAATGAGA AATACTAATAGAATGTGGCACTGAGCCACAAGGTCTGAGGGTTGATTGATAAGGAAGGGTGGGGACTGTG GAGAATTAAGGGCTTGGCACAGTCAGTTCCACCAGTTGTCACAAGAGAATGCAGGCTCAGGTGGCCAGAA CTTCTCGCTTTTCCAGAAGAGTCCGATATTCTGATTTCATTATATATAGTATTCTGATTAAACCAGACAA TAAAGCAAGCAGATAAAATATTTAAATTATAAGCTGCCAGTTTGCAACCTCCGGTTAGGATTTGTGTGGG GCAAAGAAAAAAACTCTCAGGATCATTGGTATGTAGACTCTAATTTTAAGTTTCTAATTTAAAATTGGCC CCTGAGGCTGGGCGTGGTGGCTCACACCTGTAATCCCAGCATTTTGGGAGGCCAAGGTGGGTGGATCTCT TGAGGTCAAGAGTTCAAGGCCTGCCTGGCCAACATGGTGAAACCCTGTCTCTATTAAAAATACAAAAATT AGCTGGGCATGGTGGTGCATGTCTGCAATCTTAGCTACTTGGGTAGCTAAGGCAGGAGAATTGCTGGAAC CCGGGAGGTAGAGGTTGCAGTGAATGGAGATCACACCACTGCACTCCAGTCTGGGCAATAGAGAGAGACG CTCTCTCTAAAAAAAAATATGTAAAGATAAATAAAATGAAATAAAATAGGCCTCTAATGAGCAGGCCATT CTCCTTTCTGGGTCTTACTTTCCTTGCACTCCTTTCTGGGTGTTAAGAGGAGGTCTAGAGGAAGCTGGAC AACTCTTAGCTTGTAGTAAGCACAGTGGAAGTGTCAGCTCTTAATGGGTCATGGACACGTTACAAGCTAG GCGCCTTGCTGAGCACTTTACATGGTTTATCCCACTGAACCCTCTCAATAACCCTATGAGGAAGGGCTAT TATTGCTCACATTTTCAGAAGAGGAAATGGATATAGAGAGATTAGATAATTTGCCCATGGCCAGACAGCT AGTATAAGAGGAGGAGGTGGATTGACTGCAGACATTCTGTCTTCAAACCACTACACTATGCTATGGGGGC ACAGAGACTTAATGAAATCATGGAGAGGGGAATTGCTTTGTCAACCACAAGCAGTTATTCCGGGGGCAGC AGATCCTCCCCTGTCCCCCAGTGGGTACAATGGTCCCTGGTGGGTTGTGCTACAATGTTAGCCCATGGTC TTATGTGTTTTTCAAATGTGTAAAGTAGGATGCTGGAACCACTCTTAGAACCAGATACCAATACATTGTG AAGAAATAAATCTCTGTGCTTAAAACTGGTTCATCCCAAAATATTTTGAACTGACACACAATAGGTGCTA AATAAATGTGTGTTAACTTGAATTGGATTGAATTCGGGAAAAAAGTGCAATAAGCTTAGTGAAGACACCA TGTTCCCTGGGTAGAGGAACCACATTCTCCATCTAAGGCCAGGAGTATGGGAGGTATCAATGTTTGCCCA GCACAGAACAGGGTGCCAAGAAGAGAAAAGTTGACGGGGTGCATACTCGGACTGGAAACTGGAAGGGTGA GAACAGAGGGTAAAGGATAGAGATGGAACCATGTGCATACACTTTGTGTTACCTTGGACAAGTCATTCAT TTCTCTGGACCTCTGCTTTCTCTCTACACAATGGGGTCCCACCACTTCCCTTACAGCTGACTTGTATGAA GAAGGAGGTGGAGGAGGAGGAGAAGGTGAAGACAATGCTGACTCAAAGGGTAAATTATTTTTAGGATCCA AGTTTGAAAACAATTTTAGGCTACTAGATATGAACAACATCTTGATTATGTAGTTGAAGGAAATTAAAGA TGAATGGTTTAATTAAAAATTAATCAGAATGAAAACGATTGATTACTAATATATCTGCAATGGTTTATTT TCCTGAGTGGCAGACTCACTAAGGTTTTTGAATACTCCTGTGTGATTGCTCTATGTATGTATGTATGTAT GTATGTATGCATGTATCTATCTATCTGTTGTCTAATAAAATGGATCACATCTCTGCTAATAAAAACACTA CACTGGCAGGGTACAATTATAATCATTAACTGTGCCTGGAATTTGCAGCAGCAGCCACCAGAGGTACCAG TGCCCTTTAAGGGTTCATAATTTAGAATAATCCAATTATCTGAGTTTTTCAGGGACTGAGGGGTTTGGCA AGGTGTAGAACTTTCAGTAATAAAGTCAAGAAAGTCCTGGACAAACCAAGGTAGTTGGTCACTCTAGTCC ATAACCAGGTAAAGAGCTTTCCCTGTAACCTGTGTAAGGTTTTAGAATCATTTCTTTCCTTATTACCAAA AATCCTCCCCAAATTTTCAAGAAATTATGAACTAAATAGTTACTCTATGAGATAGGAGTTCAGCCCAAAA GAAACACCATAAGAACAAATATAATTCTTGCTTATGTTAACCATGCAATGAAGCAGAGAGAAAAAGTCAG TGGCCTCTTTAGGAGGACTGTAGTGTGGGAAGAAATAACTAAACTGGGTTTCAATCCTGGCCTGGCCAGG ATCTGGAGCAAGTGAGTTAATCTTTCTAAGCCTTGAGTAGTTTCTTCTTCTTCTTCTTCTTCTTCCTCCC CCTTCTCCTCTTCTTCTTCCTCCTCCTTCTCCTCTTCTTCTTCTTCTTCTTCTTCCTCTTCTTCTTCTTC CTCCTCCTCCTCCTCCTCTTCTTCTTCTTCTTCTTCCTCTTCCTCTTCCTCTTCTTCCTCTTCCTCTTAT TCTTCTTCATCGTCTTCGTCTTCGTCTTCTTTTTATTTTCAAAGTGAAAGCAAGTTTATTAAGAAAGTAA AGGAATAAAAGAATGGCCACTCCATAGACAGAGTAGCCTGAACCTTGAGTTCTTCTATAAAGTCACTATG AATTTATACTCATTTTGAAAGTGGGTGTCAATATGTCTGTCCACTTTGCACAGCTGTTATGTGGACAAAA GGAGATCTGTGTGAAAGTGTAACACAGAGCCTAAACTATAACAGGTAAGCAACACAGTTGTCCCCTTCCC CATGGTGTCTGTTCTTCTCCATTTCCTCCTGTCTGCAGGGGGATTATAAAACTAATCATCAAAGCCAAGA AGGCAAGAGCAAGCATGTACCGCTGAAAACACAAGATAACTGCATAAGTAATGACTTTCAGTGCAGATTC ATAGCTAACCCATAAACTGCTGGGGCAAAAATCATCTTGGAAGGCTCTGAACCTCAGAAAGGATTCACAG TAAGTTAACCATGTAGATCTGAGAGGAGAGTAGCTTCTTGTAGATAACAGTTGGATTATATACCATGTCC TGATCCCCTTCATCATCCAGGAGAGCAGAGGTGGTCACCCTGATAGCAGCAAGCCTGGGGGCTGCAGCTT GGTGGGTAGAGGTACTCAGGGGTACAGATGTCTCCAAACCTGTCCTGCTGCCTTAGGGAGCTTCTAATAA GTTGATGGATTTGGTTAAAATTAACTTGGCTACTTGGCAGGACTGGGTCAGTGAGGACCAACAAAAAGAA GACATCAGATTATACCCTGGGGGTTTGTATTTCTTGTGTTTCTTTCTCTTCTTTGTACTAAAATATTTAC CCATGACTGGGAAAGAGCAACTGGAGTCTTTGTAGCATTATCTTAGCAAAAATTTACAAAGTTTGGAAAA CAATATTGCCCATATTGTGTGGTGTGTCCTGTGACACTCAGGATTCAAGTGTTGGCCGAAGCCACTAAAT GTGAGATGAAGCCATTACAAGGCAGTGTGCACATCTGTCCACCCAAGCTGGATGCCAACATTTCACAAAT AGTGCTTGCGTGACACAAATGCAGTTCCAGGAGGCCCAAATGAAAATGTTTGTACTGAAATTTGTTAAAG CTTCCCGACAAACTAGATTTATCAGTAAGGATTGTTTTCTGCAAGGGGGATGAAACTTGTGGGGTGAGCC ATTTGGGCTGAGGAGGAGGGAGGTTGGAGCTGAGAAATGTGGAGACAATTTCCCTTTAGAAGGACTGAAT CTCCCTGCCTCTCTGGGGTGCGGCAGCCAGCAGGATCCAATGGTGTATATGTCTCCCCAGCTCCCCATTC AGTGATATCATGTCAGTAGCTTGAAATTATCCGTGGTGGGAGTATTATGTCATGGAAATTGGCAAATGGA AACTTTTATTGGAGATTCAATTGTTAAACTTTTACCAGCACAACACTGCCCTGCCTTCAGAGTCAATGAC CCTATCCAAGTTTAATCCATCTGTCCACTGTCTCCAACACGATCTTTATAAAACACACCTGACAACATTA CCCTTTTATTCAGTTTTTTAAAAGATAAGTTTCCAGCTCATCGGGCTGGCTTTAAAGGCCATTTCTCCTC TGGACCTCACCCAACTTTTCAAATCACTTTTCCTACCCCTACCTCTAAATGCTACTCAAACTCCAGCCAT CCTGAATAATAAGACTTTTGAAAAGTAGATTATGGGCTGGGCACAGTGGCTCACACCTGTAATCCCAGCA CTTTGGGAGGCCAAGATGGGTGGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTGACTAACATAGTGAA ACCCTGTCTCTACTAAAAATACAAAATTAGTTGGGGGTGGTGGCACAAGCCTGTAATCCCAGCTACTCAG GAGGTTGAGGCAGGGGAATTGCTTGAACCTGGGAGGCGGAGGTTGCGGTGAGCCTAGATTGCTCCACTGC ACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAATAAATAAATAAATAAAGTAGATTACAT CAGATACCTCTGGCCTAGGTTGTTTATGACCAACTCTCCTGCTGAGAATAACTAGAAAAGCTAGACAAAA CATATTTCCAAAAGATCTCTTTGGAGGCATCAGAGAATGGCCAAGGCTGTAAGGAACTGCCTGAGCCCAG AGAGGTGGAGCCCAGCACTGGTGCCCTTTACTCCTGGGGACATGTGCTGGTTTCAAAAACTTCAGCTGAG TTTTTGAGCATTCATGGAACTTGGTGGGGGAGATGAAATTTGTACCTTAAATCCTGCCTACAGGGAGGGT CCCTGATAATCCCCACCCAATTTGGAAATCTGGGTCAGCCTTCACAGGTACTGAAGCCCTCCTCTGAATG ATCTCAAGTCCTGCTAGGGTAGAGGTTACCTGCTTTTGAAAGGCTCCTGGCCTACCTGTGCAGCAGGAGC AAAAGTGAACCATCTCAGGGTACAGATAACAATCATCCAGAGCCTTGAATGACCTCTACTGTGCTTAATA TATAGTATTCAGCAGTCAGTAAAAAGGATTTAGGCACATGCAAGATGACCTGTGTATCAGGGAGAAATAG GCAATAAATTGAGATCCAGCAGGGATTTGAATCATGGATTTGAATCAGGGGCAGCCTTCGAAAGAACTGT GGAGAATATACTCAGATTTAAAACATAAGATTGGAATTTTTGGCAGAGAACTAACAACTGTACAAAAAAG GAACCAAATGGAAATCCTAGAACTGAAAGATGCAATTAACCGATGTTGAGAAATAGCCAACATCTATTGA ACACTTCCCATGTGGACAGCTGTGCTAAACACTTTACAGGCATCAACATAAGATGTGTCCCCTTACAGCA GTGCAGTGTCCCTCCTAAGACATGGACAGCCTGGTTTCCCTATCTCTCTGCTTCATCAAAACCCCTTTAC GTGGGGCTTAGACACTCCTGTTGTCTCTAGTGTCTAGTAGCACAGGGCTCAGCACATGGAAGCCACTAGA TACAATTTGATGACCAGGACCTCCGATGAAAGCCATGGGTGCTGATTGGGAAGGCATTGTCTTTTATGTG CTATGGTCTTAAAGCTTCATCCAGGAAGCAGAACTCGGGGGGTGCTGAGGACCCAGAACCGAGAATAAGA TTAGTCAGAGATTTCCTGTGGGCAGAAATCATAAGGACGCCAACTGTTTGGGTGAGATAAGACGAAACCA AGAGTGGACTTGTGGCCAGAAGCGTGAGGAAGAGGGAGAGAGCTTCCCTTGTCCCCTTTCTTCCTCTCCC TAAGCCACAGTGATTGACAGCCCCCCCCCTTTGGAGTCAGAGCAGGCTTGAGACTGGACTGGGAAAGGAG GGTGGGTCAGGATACAGAGCAGGAAGGCTGGGAGTGCAGGGCAGGAGCAAGGGGCTGGGGCATTCATTGT GCCTGATCTCTCCCACTTTACCTGGGGTAAAGAAGCATATGCAAAAGCCACGGTGTGAGTATTTCCCAAG TGCCAGGGTCAGGGCATGATTCATCACGTGCAGCATTTCATTCAATCCTTATAGTAACCGATGATGTGGC TTCTATTATTAGCTCTATCAGATAATGAAACTGAGACCAAGACAGGCTCTGCACATTGTGTGGGGTAATG ACACAGGGGGATTCAGACCTAGACTCCATAACTCCTGCCCCAGGGACCACCCCCACCCTCACCCTGTGCA TGTCGACAAAGGACAGACTGGGCCACTTCTCAGGACACAGCGGGGAAATGACACAGAGCAGGGAGGTTCC AGGAGCCCCGAGCGTCTTTTCTCCAGGAGAATACTCTCTGAATTCAGACTGGGGTCAGAGAAACATTTAC CCAGGAGCCGCAGTGTGGGTGGGGCTTTTTACTTGAAACGCTGTCTGAAGGCAGTGGCCAGGATGGAACT CTCCACCCTACCTTGGCAAGCCACTTCTCTTCTGCAATCTGTAAGGACATTGTTGAGAGAATTATGGTCT TCCAATTCCGGAGGGTTGAAGAAAGACAAATAGGAGAGAACCTATCATAGTCAGGTGCTAGCTGCCTTCT CTTTCAGAGAGTGTGAGAATAAAGTGATACACTTGATTATTAGCAAATACTTTGGAAATTTTAAACGCTA ATATTCAACACACTCTGGAAGAGGCAAATAAGTAGACAGGTTCATATACATCATCTCCTTCAGCTAGTCC TCACAAAAACAAACAAATGAATAAACAAAATTCTTCTTTGGCCCTCATAGGAAGACACTGTTTCTTGAAC GTGTTTCAAAAAGGATGGGTGACTCACTCAAGGTCACACTGTTTATGAGGACAGTACAGGAATACAGACA TGCCATTTTGCCTGAAAAAATCCATCACCCAGGGAGGTGACACAATTTTGCAGAAATGTTCTATTTCCTC TGAAGGATACATTCTTTAAACCTTTGGGAAATTCATTCATAGTCTTCCTCCTTTGAAGGATTAACTCTCT GGACACAAAGTGTTTGATTCTGATTTGTTGGTTGGAAGATGTGTTGGTTGAGAGAAAGATTCTGATTTGT TGGTTGAAAATAGACTCATCAAGATCAACTGCTGTAGTAGTAAATATTTTGACATTTTGTCTGTATTCCT GTGCTGCCCTCACAAGCTGCATCACCTTGAGTGAGTCATTCATACTTTTTTGTTTGTTTTTGTTTTGGAG ATGGAGTCTTACTCTGTTGCCTAGGCTGGAGTGCGGTGGCGTGATCTTGGCTCACTGCGACCTCCATCTC CTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACATGCCACCATCCCT GCTAATTTTTGCATTTTCAGTAGAGACGGAGTTTCACCATGTTGGTCAGGTTGGTCTTGAACTCCTGACC TCAGGTGATCCGCCCACCTCAGCCTCCCCAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCCA GCCATCATTTTTGAAACACGTTTGAGAAATAGTGTCTTCCTTTGAGGGCCAAGGAGACATTTTTTTTGTT TATTTGTTTGTTTTTGTGAGGACTAGCTGAAGGGGGTGATGTATATTAACCTGCCTACTTATTTGCCTCT TCCCAGAGTGTGATGAATATTAGGGTTTAAAGTTTCTGAAGCATTTGTTAATAAAGCCCGGGGCTGGAGG TCAGAAGACCTGGATTTCTCTGCATACTTTTGCCATCAGCAAGCTGTGTGACCTTGGACAGATCCCTTTT TTGTCTAAATCTTTCTGAGTCTTCTTGAAAACAATGCCAGGTTGGGACAGGATGATTGCCAAGCTCCCGT CCAGCTCTAAAACACTGCAACGTATGCTTCTGCACCAGCACTGTCCATCCTGTAGATCATGCAGAAATTC TCTTCAACTTTTTCCTACCCATAAAATAGGAGCATGCTTACCTTTTTCCTAATGTTCCAGGCCCCGGGTC TAGAATATTGTAAGTAAGGAAGTTAATGTGTATCAGAGCCCATTATGGGCCAGAAGTTCTCCTCTTCCTT CCTACACCTGCTTCCTCCCTCCCTCCCTCCCTCTTTCCCTTCCTTCCTTCCATCCATTTGTGAAGAAGAC ATGATCACCCTCATTCTGAGAGTGAAGAGACAGAGGCTCAACTAATGAAATGATTTGTTCAAGGTCACAC GGGTGGCACAAGGCAAGTGGCAGAGGTTGAATTTAGACCCATTCCTGTCCAAATGCTGAGTTTATGTCAT CGTCCCGAGACCATAACTTTAAAGATGTAAGATAGTGGGAAAAGAGTTGATTTCAAAGCACCTCTCAGAA GGACTCACTTTACATCAGGGGTCAGCAGACTCAGGCCAAATCCGGTCCATTCCCCGCTTTTGCAAAGAAA GTTGTAGTGGAACACAGCTAGGCTTATTGATTTATGGATTGCCAACGTCCTTTTGTGAAACAGACAGCTG AGCTGAGTAATCGTGGCGCACAAAACCTAAAATATTTACTATCTCGTCCTTTACAGAATGTTTGCCAATC TATGGTCCGGAGTCCAAGGCTGTCCATTTTTCAAAGAACACAAAGTGACATGAGACTGTCCCATGTGCAG GGAGCCCTATCATTTTATTATGAAAAAACGGCCTTTCTGCTCAAATCTGTTTTTTAAAAAGTCAACAAAC AGACTCTGGGTACCTGTCAGGAACAGTAGGGAGTTTGGTTTCCATTGTGCTCTTCTTCCCAGGAACTCAA TGAAGGGGAAATAGAAATCTTAATTTTGGGGAAATTGCACAGGGGAAAAAGGGGAGGGAATCAGTTACAA CACTCCATTGCGACACTTAGTGGGGTTGAAAGTGACAACAGCAAGGGTTTCTCTTTTTGGAAATGCGAGG AGGGTATTTCCGCTTCTCGCAGTGGGGCAGGGTGGCAGACGCCTAGCTTGGGTGAGTGACTATTTCTTTA TAAACCACAACTCTGGGCCCGCAATGGCAGTCCACTGCCTTGCTGCAGTCACAGAATGGAAATCTGCAGA GGCCTCCGCAGTCACCTAATCACTCTCCTCCTCTTCCTGTTCCATTCAGAGACGATCTGCCGACCCTCTG GGAGAAAATCCAGCAAGATGCAAGCCTTCAGGTAAGGCTACCCCAAGGAGGAGAAGGTGAGGGTGGATCA GCTGGAGACTGGAAACATATCACAGCTGCCAGGGGCTGCCAGGCCCCAGAGGGCCTGAGAACTGGGTTTG GGCTGGAGAGGATGTCCATTATTCAAGAAAGAGGCTGTTACATGCATGGGCTTCAGGACTTGTGTTTCAA AATATCCCAGATGTGGATAGTGCGACCGGAGGGCTGTCTTACTTTCCCAGAGACTCAGGAACCCAGTGAG TAATAGATGCATGCCAAGGAGTGGGACTGCGATTCAGGCCTAGTTGAATGTGCTGACAGAGAAGCAGAGA GGGGCACCAGGGGCACAGCCCGAAGGCCCAGACTGATATGGGCAAGGCCTGTCTGTGCTGACATGTCGGA GGGTCCCACTCTCCAGGGACCTTGGTTTCCCCGTCTGTGACATCTGTGACATGAGAGTCACGATAACTCC TTGTGTGCCTTACAGGGTTGTTGTGAAAATTAAATGCACAGATAATAGCGTAACAGTATTCCGTGCATTG TAAAGAGCCTGAAAACCATTATGATTTGAAAATGGAATCGGCTTTGTGAGACCATCACTATTGTAAAGAT GTGATGCTGATAGAAATGACAGGACTGCTTGTGCATGCCCTCTGCAGTGTGACATTCCAGCAGTGAAATC ATGTTGGGGTGACTTCTCCCCCACTCTGACCTTTATGTTTGTCTGGGCCGAGGCTGCAAGTCGGGCTCTG TGGGTGTATGAGTGACAAGTCTCTCCCTTCCAGATATGGGGACTGTCTGCTTCCCTAGGTTGCCTCTCCC TGCTCTGATCAGCTAGAAGCTCCAGGAGATCCTCCTGGAGGCCCCAGCAGGTGATGTTTATCCCTCCAGA CTGAGGCTAAATCTAGAAACTAGGATAATCACAAACAGGCCAATGCTGCCATATGCAAAGCACTTTGGTT TGCCTGGCCACCCCTCGTCGAGCATGTGGGCTCTTCAGAGCCACCTGATGAGGTGGGTACAGTTAGCCAC ACTTCACAGGTGAAGAGGTGAGGCACAGGTCCCAGGTCAGGCTGGCCAGAGCTCTGTTTATTACGTCTCA CAGCTTTGAGTCCTGCTCTCAACCAGAGAGGCCCTTTACCAAGAAGAAAGGATTGGGACCCAGAATCAGG TCACTGGCTGAGGTAGAGAGGAAGCCGGGTTGTTCCCAAGGGTAGCTGCTCCTGCAGGACTCTGAGCAGG TCACCAGCTAATGGAGGAAAGGCTCTAGGGAAAGACCCTTCTGGTCTCAGACTCAGAGCGAGTTAGCTGC AAGGTGTTCCGTCTCTTGAAACTTCTACCTAGGTGCTATGGTAGCCACTAGTCTCAGGTGGCTATTTAAA TTTATACTTAAATGAATGAAAATAGAAGAAAATTTAAAATCCAGACCCTTGGTCACACTATCCACATTTA AAGAGGTCAATAGCCACATGTGGTTAGTGGCCACCCTATTGGGCAGTGCAGCTACAGAACATTTTTGCAT CCCAGAAAGTTCTTTTGGATGTTGCTGCTCTACAGCATGCTTTGCTGAAACAGAAGTGCCTTCCCTGGGA ATCTCAGATGGGAAGCAAGTAAGGAGGGGAGTCAAATGTGGGCTCACTGCTCACCAGCTGTGAGGGTTGG GCCTGCCTCTTAACCATTGTCAGCCTCAGTCTTCTCATCCATGCATGCCGTGGGTATACTAAAATACTAT ACCCCTGGAAGAGCTGGATGCAAATTTGACAAGTTCTGGGGGACACAGGAAGGTGCCAAGCACAAGGCTG GGCACATGGTGGCTGTGCACTACAGCTGAGTCCTTTTCCTTTTCAGAATCTGGGATGTTAACCAGAAGAC CTTCTATCTGAGGAACAACCAACTAGTTGCTGGATACTTGCAAGGACCAAATGTCAATTTAGAAGGTGAG TGGTTGCCAGGAAAGCCAATGTATGTGGGCATCACGTCACTTTGCCCGTCTGTCTGCAGCAGCATGGCCT GCCTGCACAAACCCTAGGTGCAATGTCCTAATCCTTGTTGGGTCTTTGTATTCAAGTTTGAAGCTGGGAG GGCCTGGCTACTGAAGGGCACATATGAGGGCAGCCTGAAGAGGGTGTGGAGAGGTAGAGTCTAGGTCAGA GGTCAGTGCCTATAGGCACAGTGGTCCCAGGGCCACAGCTGGGAAGGGCAAATACCAGAAGGCAAGGTTG ACCATTCCCTTCCTCAAGTGCCTATTAAGGCTCCATGTTCCTATGTTGTTCAAACCCTAACTCAATCCCA AATTAATCCACCATGTATAAGGTTGAGCTATGTCTCTTATTCCTGGACACCATACTCAGCCATATTCTGG TCCACACATTAAACAAGCTGGATGACCTTGAAGAAGCTTCACCCACTCTGTTCCTCAGCTTTCCCTTCAG TGGGATGATATCAACTGGACAACAGGATGTGCGATTCTTTTAGTTCCAGCCTTCCAGGATGTTTTCACTC CCCTGTTTGTTGTTGTAGGATGGTATTACCTCCACCTTCCCACCTTCCCTATGCCCTGGTTCTGTCTCCT GTGCCTCGCTCTGAAAGTGGATGAGACCTACAATTCCTGTCCTGGTAGTTCTCCTAATGAACACACTGAA GCACGAGGAAGCTGAGATTTTTGTTGCTACATGAGAGCATGGAGGCCTCTTAGGGAGAGAGGAGGTTCAG AGACTCCTAGGCTCCTGTGGAGCCCCACTCATGGCCTTGTTCATTTTCCCTGCCCCTCAGCAACACTCCT ATTGACCTGGAGCACAGGTATCCTGGGGAAAGTGAGGGAAATATGGACATCACATGGAACAACATCCAGG AGACTCAGGCCTCTAGGAGTAACTGGGTAGTGTGCATCCTGGGGAAAGTGAGGGAAATATGGACATCACA TGGAACAACATCCAGGAGACTCAGGCCTCTAGGAGTAACTGGGTAGTGTGCATCCTGGGGAAAGTGAGGG AAATATGGACATCACATGGAACAACATCCAGGAGACTCAGGCCTCTAGGAGTAACTGGGTAGTGTGCATC CTGGGGAAAGTGAGGGAAATATGGACATCACATGGAACAACATCCAGGAGACTCAGGCCTCTAGGAGTAA CTGGGTAGTGTGCTTGGTTTAATCTTCTATTTACCTGCAGACCAGGAAGATGAGACCTCTCTGCCCTTCT GACCTCGGGATTTTAGTTTTGTGGGGACCAGGGGAGATAGAAAAATACCCGGGGTCTCTTCATTATTGCT GCTTCCTCTTCTATTAACCTGACCCTCCCCTCTGTTCTTCCCCAGAAAAGATAGATGTGGTACCCATTGA GCCTCATGCTCTGTTCTTGGGAATCCATGGAGGGAAGATGTGCCTGTCCTGTGTCAAGTCTGGTGATGAG ACCAGACTCCAGCTGGAGGTAAAAACATGCTTTGGATCTCAAATCACCCCAAAACCCAGTGGCTTGAAAC AACCAAAATTTTTTCTTATGATTCTGTGGGTTGACCAGGATTAGCTGGGTAGTTCTGTTCCATGTGGTGG AACATGCTGGGGTCACTTTGGAAGCTGCATTCAGCAGAGTGCCTGGCTTGCGCTGGGCATCCAAGGTGGT CCCTCATCCTCCAGGCTCTCTTTCCATGTGATCTCTCAGTGTTTAAGAGTTAGTTGGAGCTTCCTTACAG CATGGCGGCTGACTTCCAAAAGGGATTATTCCAAAAAGAGCCTCAACATGCAGGCGCTTATTATGACTTC TGCTTGCATCATCCTATTGGCCAAAGCCAGTCACGTGGCTAAGTCTAGCCCCCTGTGAGAGGAGACTGCA TAAGAGTGTGAACACCAGGAGACACGGTCACTGGGGGCCACCACTGTAACCATCTACCACAGGACCTGAA TCTCTGTGTGCTACTCCCTTGCTCAAGGGCCCCCCTACCCACGCAGACCTGCTGTCTTCTAGCAAAGCCC ATCCTCAGGACCTTTCTCTTCCAATCCTTATTGACTCAAATTGATTAGTTGGTGCTCCACCCAGAGCCCT GTGCTCCTTTATCTCATGTAATGTTAATGGGTTTCCCAGCCCTGGGAAAACATGGCTTTGTCTCAGGGGC TTGCTGGATGCAAGCTTAACCTCAATGTGAGTGGCCATACTGTGGCACTGTCCCATCCCTCACCAGGGAC ACTGTTCTGGAGGGTGACTGCCTGTTCTGTGAGGAGTGGGGATGGCTAGGACATTGCATGGAACACACCA CCACCCCATCTTCTCAGAGCTCAAACCCTGACAGAACACCAGCTCCACAGGCCTTGGCTTCTGCTGATGG TGCCGTGTATTTACCAGACTTAGTGGTCCAAGGCCAGAGTGGCCAGATTTCCCAAAGTCAAGGTGTGACA GTGGGACAGCCTCTTTGTGTCTTTGCTGTCCTAAGAAACCTGGGCCAGGCCAGGCGCAGTGGCTCACGCC TGTAATCCCAGCACTTTGAGAAGCCAAGGTGGGCAGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGCC AACATGGTGAAACCCTGTCTCTATTAAAAATAGAAAACATTAGACAGGTGTGGTGGTGCATGCCTGTAAT CCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAG ATTGTGCCACTGCACTCCAGCCTAGGCGACAGAGCAAGACTCCGTCTCGGGAAAATTAATTAATAAATAA ATAAACCTAGGTCCCAGAGTCCCACAGAATGGCAGACAGGAGCACCTGGGGGCTTTTAGGGTATGGCATT TCCCCTGTACTAACTCTGGGCTGTCCAGAGGGCCATTTCATGGCGTGGAGTGGAGAGGGAGGCAGCACAG GACTTCCTAGGCCTCAGCTCTCACCTGCCCATCTTTTGATTTCCAGGCAGTTAACATCACTGACCTGAGC GAGAACAGAAAGCAGGACAAGCGCTTCGCCTTCATCCGCTCAGACAGTGGCCCCACCACCAGTTTTGAGT CTGCCGCCTGCCCCGGTTGGTTCCTCTGCACAGCGATGGAAGCTGACCAGCCCGTCAGCCTCACCAATAT GCCTGACGAAGGCGTCATGGTCACCAAATTCTACTTCCAGGAGGACGAGTAGTACTGCCCAGGCCTGCCT GTTCCCATTCTTGCATGGCAAGGACTGCAGGGACTGCCAGTCCCCCTGCCCCAGGGCTCCCGGCTATGGG GGCACTGAGGACCAGCCATTGAGGGGTGGACCCTCAGAAGGCGTCACAACAACCTGGTCACAGGACTCTG CCTCCTCTTCAACTGACCAGCCTCCATGCTGCCTCCAGAATGGTCTTTCTAATGTGTGAATCAGAGCACA GCAGCCCCTGCACAAAGCCCTTCCATGTCGCCTCTGCATTCAGGATCAAACCCCGACCACCTGCCCAACC TGCTCTCCTCTTGCCACTGCCTCTTCCTCCCTCATTCCACCTTCCCATGCCCTGGATCCATCAGGCCACT TGATGACCCCCAACCAAGTGGCTCCCACACCCTGTTTTACAAAAAAGAAAAGACCAGTCCATGAGGGAGG TTTTTAAGGGTTTGTGGAAAATGAAAATTAGGATTTCATGATTTTTTTTTTTCAGTCCCCGTGAAGGAGA GCCCTTCATTTGGAGATTATGTTCTTTCGGGGAGAGGCTGAGGACTTAAAATATTCCTGCATTTGTGAAA TGATGGTGAAAGTAAGTGGTAGCTTTTCCCTTCTTTTTCTTCTTTTTTTGTGATGTCCCAACTTGTAAAA ATTAAAAGTTATGGTACTATGTTAGCCCCATAATTTTTTTTTTCCTTTTAAAACACTTCCATAATCTGGA CTCCTCTGTCCAGGCACTGCTGCCCAGCCTCCAAGCTCCATCTCCACTCCAGATTTTTTACAGCTGCCTG CAGTACTTTACCTCCTATCAGAAGTTTCTCAGCTCCCAAGGCTCTGAGCAAATGTGGCTCCTGGGGGTTC TTTCTTCCTCTGCTGAAGGAATAAATTGCTCCTTGACATTGTAGAGCTTCTGGCACTTGGAGACTTGTAT GAAAGATGGCTGTGCCTCTGCCTGTCTCCCCCACCGGGCTGGGAGCTCTGCAGAGCAGGAAACATGACTC GTATATGTCTCAGGTCCCTGCAGGGCCAAGCACCTAGCCTCGCTCTTGGCAGGTACTCAGCGAATGAATG CTGTATATGTTGGGTGCAAAGTTCCCTACTTCCTGTGACTTCAGCTCTGTTTTACAATAAAATCTTGAAA ATGCC
Protein Name	IL1RA_HUMAN
Length	177
Moltype	AA
Topology	linear
Division	PRI
Update Date	12-OCT-2022
Create Date	01-NOV-1990
Definition	RecName: Full=Interleukin-1 receptor antagonist protein; Short=IL-1RN; Short=IL-1ra; Short=IRAP; AltName: Full=ICIL-1RA; AltName: Full=IL1 inhibitor; AltName: INN=Anakinra; Flags: Precursor
Primary Accession	P18510
Accession Version	P18510.1
Other SeqIDs	sp\|P18510.1\|IL1RA_HUMAN,gi\|124312
Organism	Homo sapiens
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Comment	On or before Jul 13, 2012 this sequence version replaced gi:74726700, gi:88009, gi:7438656.; [FUNCTION] Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. {ECO:0000250\|UniProtKB:P25085, ECO:0000269\|PubMed:7775431}.; [INTERACTION] P18510; Q9NYB0: TERF2IP; NbExp=2; IntAct=EBI-1026330, EBI-750109.; [SUBCELLULAR LOCATION] [Isoform 1]: Secreted {ECO:0000269\|PubMed:32384874}.; [SUBCELLULAR LOCATION] [Isoform 2]: Cytoplasm.; [SUBCELLULAR LOCATION] [Isoform 3]: Cytoplasm.; [SUBCELLULAR LOCATION] [Isoform 4]: Cytoplasm.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P18510-1; Sequence=Displayed; Name=2; Synonyms=icIL-1ra; IsoId=P18510-2; Sequence=VSP_002649; Name=3; Synonyms=icIL-1ra type II; IsoId=P18510-3; Sequence=VSP_002650; Name=4; IsoId=P18510-4; Sequence=VSP_002651.; [TISSUE SPECIFICITY] The intracellular form of IL1RN is predominantly expressed in epithelial cells.; [DISEASE] Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. {ECO:0000269\|PubMed:8786086}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; [DISEASE] Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. {ECO:0000269\|PubMed:19494218}. Note=The disease is caused by variants affecting the gene represented in this entry.; [PHARMACEUTICAL] Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis.; [SIMILARITY] Belongs to the IL-1 family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-1 entry; URL='https://en.wikipedia.org/wiki/Interleukin_1'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il1rn/'.; [WEB RESOURCE] Name=Kineret professional medical information; URL='https://www.rxlist.com/kineret-drug.htm'.
Source Db	UniProtKB: locus IL1RA_HUMAN, accession P18510;; class: standard.; extra accessions:A8K4G1,Q14628,Q53SC2,Q7RTZ4,Q96GD6,Q9UPC0; created: Nov 1, 1990.; sequence updated: Nov 1, 1990.; annotation updated: Oct 12, 2022.; xrefs: X53296.1, CAA37386.1, X52015.1, CAA36262.1, M63099.1, AAB41943.1, X64532.1, CAA45832.1, U65590.1, AAB92270.1, AAB92268.1, AAB92269.1, M55646.1, AAA59138.1, X84348.1, CAA59087.1, AY196903.1, AAN87150.1, AK290898.1, BAF83587.1, AK290926.1, BAF83615.1, AC024704.9, AAX93278.1, CH471217.1, EAW73625.1, BC009745.2, AAH09745.1, AF043143.1, AAC39672.1, BN000002.1, CAD29879.1, A30368, A39386, NP_000568.1, NP_001305843.1, NP_776213.1, NP_776214.1, NP_776215.1, XP_005263718.1, XP_011509423.1, 1ILR_1, 1ILR_2, 1ILT_A, 1ILT_B, 1IRA_X, 1IRP_A, 2IRT_A, 2IRT_B; xrefs (non-sequence databases): CCDS:CCDS2113.1, CCDS:CCDS2114.1, CCDS:CCDS2115.1, CCDS:CCDS46396.1, PDBsum:1ILR, PDBsum:1ILT, PDBsum:1IRA, PDBsum:1IRP, PDBsum:2IRT, AlphaFoldDB:P18510, SMR:P18510, BioGRID:109772, IntAct:P18510, STRING:9606.ENSP00000259206, BindingDB:P18510, ChEMBL:CHEMBL4523191, DrugBank:DB06372, DrugCentral:P18510, Allergome:11858, GlyConnect:1947, GlyGen:P18510, iPTMnet:P18510, PhosphoSitePlus:P18510, BioMuta:IL1RN, DMDM:124312, EPD:P18510, jPOST:P18510, MassIVE:P18510, MaxQB:P18510, PaxDb:P18510, PeptideAtlas:P18510, PRIDE:P18510, ProteomicsDB:53572, ProteomicsDB:53573, ProteomicsDB:53574, ProteomicsDB:53575, Antibodypedia:806, CPTC:P18510, DNASU:3557, Ensembl:ENST00000259206.9, Ensembl:ENSP00000259206.5, Ensembl:ENSG00000136689.20, Ensembl:ENST00000354115.6, Ensembl:ENSP00000329072.3, Ensembl:ENST00000361779.7, Ensembl:ENSP00000354816.3, Ensembl:ENST00000409052.6, Ensembl:ENSP00000387210.1, Ensembl:ENST00000409930.4, Ensembl:ENSP00000387173.3, Ensembl:ENST00000696879.1, Ensembl:ENSP00000512947.1, Ensembl:ENST00000696880.1, Ensembl:ENSP00000512948.1, Ensembl:ENST00000696881.1, Ensembl:ENSP00000512949.1, GeneID:3557, KEGG:hsa:3557, MANE-Select:ENST00000409930.4, UCSC:uc002tiy.3, CTD:3557, DisGeNET:3557, GeneCards:IL1RN, HGNC:6000, HPA:ENSG00000136689, MalaCards:IL1RN, MIM:147679, MIM:612628, MIM:612852, neXtProt:NX_P18510, OpenTargets:ENSG00000136689, Orphanet:210115, PharmGKB:PA29816, VEuPathDB:HostDB:ENSG00000136689, eggNOG:ENOG502S5F0, GeneTree:ENSGT00950000182943, HOGENOM:CLU_095373_2_0_1, InParanoid:P18510, OMA:WYLCTAL, OrthoDB:1410755at2759, PhylomeDB:P18510, TreeFam:TF300203, PathwayCommons:P18510, Reactome:R-HSA-6783783, Reactome:R-HSA-9020702, SignaLink:P18510, SIGNOR:P18510, BioGRID-ORCS:3557, ChiTaRS:IL1RN, EvolutionaryTrace:P18510, GeneWiki:Interleukin_1_receptor_antagonist, GenomeRNAi:3557, Pharos:P18510, PRO:PR:P18510, Proteomes:UP000005640, RNAct:P18510, Bgee:ENSG00000136689, ExpressionAtlas:P18510, Genevisible:P18510, GO:0005737, GO:0070062, GO:0005615, GO:0005886, GO:0005125, GO:0005152, GO:0005149, GO:0045352, GO:0045353, GO:0005150, GO:0005151, GO:0006953, GO:0006955, GO:0006954, GO:0002437, GO:0030073, GO:0006629, GO:0034115, GO:2000660, GO:0051384, InterPro:IPR020877, InterPro:IPR000975, InterPro:IPR003297, InterPro:IPR008996, InterPro:IPR039348, PANTHER:PTHR10078, PANTHER:PTHR10078:SF28, Pfam:PF00340, PRINTS:PR00264, PRINTS:PR01360, SUPFAM:SSF50353, PROSITE:PS00253
Sequence	meicrglrshlitlllflfhseticrpsgrksskmqafriwdvnqktfylrnnqlvagylqgpnvnleekidvvpiephalflgihggkmclscvksgdetrlqleavnitdlsenrkqdkrfafirsdsgpttsfesaacpgwflctameadqpvsltnmpdegvmvtkfyfqede