|
|
| Record Information |
| Record ID |
64 |
| Pubmed ID |
30546947 |
| SNP |
|
| Gene ID |
4102 |
| Protein ID |
P43357 |
| Vaccine Adverse Events |
weight loss, fever, emesis, diarrhea, and constipation , emesis, diarrhea, and constipation , transient decrease in circulating lymphocytes, transient decrease in circulating lymphocytes, chronic high-grade elevation |
| Vaccine |
MAGE-A3 vaccine |
| Gene Name |
MAGEA3 |
| Official Symbol |
MAGE family member A3 [Homo sapiens (human)] |
| Aliases |
CT1.3, HIP8, HYPD, MAGE3, MAGEA6 |
| Other Designations |
melanoma-associated antigen 3; MAGE-3 antigen; antigen MZ2-D; cancer/testis antigen 1.3; cancer/testis antigen family 1, member 3; melanoma antigen family A, 3; melanoma antigen family A3 |
| Chromosome |
X |
| Location |
Xq28 |
| Annotation |
Chromosome X NC_000023.11 (152698794..152702347) |
| MIM |
300174 |
| DNA Sequence |
>NC_000023.11:152698794-152702347 Homo sapiens chromosome X, GRCh38.p14 Primary Assembly
GGAGGGAAGCCGGCCCAGGCTCGGTGAGGAGGCAAGGTAAGACGCTGAGGGAGGACTGAGGCGGGCCTCA
CCTCAGACAGAGGGCCTCAAATAATCCAGTGCTGCCTCTGCTGCCGGGCCTGGGCCACCCCGCAGGGGAA
GACTTCCAGGCTGGGTCGCCACTACCTCACCCCGCCGACCCCCGCCGCTTTAGCCACGGGGAACTCTGGG
GACAGAGCTTAATGTGGCCAGGGCAGGGCTGGTTAGAAGAGGTCAGGGCCCACGCTGTGGCAGGAATCAA
GGTCAGGACCCCGAGAGGGAACTGAGGGCAGCCTAACCACCACCCTCACCACCATTCCCGTCCCCCAACA
CCAACCCCACCCCCATCCCCCATTCCCCATTCCCATCCCCACCCCCACCCCTATCCTGGCAGAATCCGGG
CTTTGCCCCTGGTATCAAGTCACGGAAGCTCCGGGAATGGCGGCCAGGCACGTGAGTCCTGAGGTTCACA
TCTACGGCTAAGGGAGGGAAGGGGTTCGGTATCGCGAGTATGGCCGTTGGGAGGCAGCGAAAGGGCCCAG
GCCCTCCTGGAAGACAGTGGAGTCCTGAGGGGACCCAGCATGCCAGGACAGGGGGCCCACTGTACCCCTG
TCTCAAACCGAGGCACCTTTTCATTCGGCTACGGGAATCCTAGGGATGCAGACCCACTTCAGCAGGGGGT
TGGGGCCCAGCCCTGCGAGGAGTCATGGGGAGGAAGAAGAGGGAGGACTGAGGGGACCTTGGAGTCCAGA
TCAGTGGCAACCTTGGGCTGGGGGATGCTGGGCACAGTGGCCAAATGTGCTCTGTGCTCATTGCGCCTTC
AGGGTGACCAGAGAGTTGAGGGCTGTGGTCTGAAGAGTGGGACTTCAGGTCAGCAGAGGGAGGAATCCCA
GGATCTGCAGGGCCCAAGGTGTACCCCCAAGGGGCCCCTATGTGGTGGACAGATGCAGTGGTCCTAGGAT
CTGCCAAGCATCCAGGTGAAGAGACTGAGGGAGGATTGAGGGTACCCCTGGGACAGAATGCGGACTGGGG
GCCCCATAAAAATCTGCCCTGCTCCTGCTGTTACCTCAGAGAGCCTGGGCAGGGCTGTCAGCTGAGGTCC
CTCCATTATCCTAGGATCACTGATGTCAGGGAAGGGGAAGCCTTGGTCTGAGGGGGCTGCACTCAGGGCA
GTAGAGGGAGGCTCTCAGACCCTACTAGGAGTGGAGGTGAGGACCAAGCAGTCTCCTCACCCAGGGTACA
TGGACTTCAATAAATTTGGACATCTCTCGTTGTCCTTTCCGGGAGGACCTGGGAATGTATGGCCAGATGT
GGGTCCCCTCATGTTTTTCTGTACCATATCAGGTATGTGAGTTCTTGACATGAGAGATTCTCAGGCCAGC
AGAAGGGAGGGATTAGGCCCTATAAGGAGAAAGGTGAGGGCCCTGAGTGAGCACAGAGGGGATCCTCCAC
CCCAGTAGAGTGGGGACCTCACAGAGTCTGGCCAACCCTCCTGACAGTTCTGGGAATCCGTGGCTGCGTT
TGCTGTCTGCACATTGGGGGCCCGTGGATTCCTCTCCCAGGAATCAGGAGCTCCAGGAACAAGGCAGTGA
GGACTTGGTCTGAGGCAGTGTCCTCAGGTCACAGAGTAGAGGGGGCTCAGATAGTGCCAACGGTGAAGGT
TTGCCTTGGATTCAAACCAAGGGCCCCACCTGCCCCAGAACACATGGACTCCAGAGCGCCTGGCCTCACC
CTCAATACTTTCAGTCCTGCAGCCTCAGCATGCGCTGGCCGGATGTACCCTGAGGTGCCCTCTCACTTCC
TCCTTCAGGTTCTGAGGGGACAGGCTGACCTGGAGGACCAGAGGCCCCCGGAGGAGCACTGAAGGAGAAG
ATCTGTAAGTAAGCCTTTGTTAGAGCCTCCAAGGTTCCATTCAGTACTCAGCTGAGGTCTCTCACATGCT
CCCTCTCTCCCCAGGCCAGTGGGTCTCCATTGCCCAGCTCCTGCCCACACTCCCGCCTGTTGCCCTGACC
AGAGTCATCATGCCTCTTGAGCAGAGGAGTCAGCACTGCAAGCCTGAAGAAGGCCTTGAGGCCCGAGGAG
AGGCCCTGGGCCTGGTGGGTGCGCAGGCTCCTGCTACTGAGGAGCAGGAGGCTGCCTCCTCCTCTTCTAC
TCTAGTTGAAGTCACCCTGGGGGAGGTGCCTGCTGCCGAGTCACCAGATCCTCCCCAGAGTCCTCAGGGA
GCCTCCAGCCTCCCCACTACCATGAACTACCCTCTCTGGAGCCAATCCTATGAGGACTCCAGCAACCAAG
AAGAGGAGGGGCCAAGCACCTTCCCTGACCTGGAGTCCGAGTTCCAAGCAGCACTCAGTAGGAAGGTGGC
CGAGTTGGTTCATTTTCTGCTCCTCAAGTATCGAGCCAGGGAGCCGGTCACAAAGGCAGAAATGCTGGGG
AGTGTCGTCGGAAATTGGCAGTATTTCTTTCCTGTGATCTTCAGCAAAGCTTCCAGTTCCTTGCAGCTGG
TCTTTGGCATCGAGCTGATGGAAGTGGACCCCATCGGCCACTTGTACATCTTTGCCACCTGCCTGGGCCT
CTCCTACGATGGCCTGCTGGGTGACAATCAGATCATGCCCAAGGCAGGCCTCCTGATAATCGTCCTGGCC
ATAATCGCAAGAGAGGGCGACTGTGCCCCTGAGGAGAAAATCTGGGAGGAGCTGAGTGTGTTAGAGGTGT
TTGAGGGGAGGGAAGACAGTATCTTGGGGGATCCCAAGAAGCTGCTCACCCAACATTTCGTGCAGGAAAA
CTACCTGGAGTACCGGCAGGTCCCCGGCAGTGATCCTGCATGTTATGAATTCCTGTGGGGTCCAAGGGCC
CTCGTTGAAACCAGCTATGTGAAAGTCCTGCACCATATGGTAAAGATCAGTGGAGGACCTCACATTTCCT
ACCCACCCCTGCATGAGTGGGTTTTGAGAGAGGGGGAAGAGTGAGTCTGAGCACGAGTTGCAGCCAGGGC
CAGTGGGAGGGGGTCTGGGCCAGTGCACCTTCCGGGGCCGCATCCCTTAGTTTCCACTGCCTCCTGTGAC
GTGAGGCCCATTCTTCACTCTTTGAAGCGAGCAGTCAGCATTCTTAGTAGTGGGTTTCTGTTCTGTTGGA
TGACTTTGAGATTATTCTTTGTTTCCTGTTGGAGTTGTTCAAATGTTCCTTTTAACGGATGGTTGAATGA
GCGTCAGCATCCAGGTTTATGAATGACAGTAGTCACACATAGTGCTGTTTATATAGTTTAGGAGTAAGAG
TCTTGTTTTTTACTCAAATTGGGAAATCCATTCCATTTTGTGAATTGTGACATAATAATAGCAGTGGTAA
AAGTATTTGCTTAAAATTGTGAGCGAATTAGCAATAACATACATGAGATAACTCAAGAAATCAAAAGATA
GTTGATTCTTGCCTTGTACCTCAATCTATTCTGTAAAATTAAACAAATATGCAAACCAGGATTTCCTTGA
CTTCTTTGAGAATGCAAGCGAAATTAAATCTGAATAAATAATTCTTCCTCTTCA
|
| Protein Name |
MAGA3_HUMAN |
| Length |
314 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-NOV-1995 |
| Definition |
RecName: Full=Melanoma-associated antigen 3; AltName: Full=Antigen MZ2-D; AltName: Full=Cancer/testis antigen 1.3; Short=CT1.3; AltName: Full=MAGE-3 antigen |
| Primary Accession |
P43357 |
| Accession Version |
P43357.1 |
| Other SeqIDs |
sp|P43357.1|MAGA3_HUMAN,gi|1170857 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Jan 19, 2010 this sequence version replaced gi:74738976, gi:631486.; [FUNCTION] Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:20864041, PubMed:31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in embryonal development and tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes (PubMed:8113684). {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:31267705, ECO:0000269|PubMed:8113684}.; [SUBUNIT] Interacts with TRIM28. {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|Ref.12}.; [INTERACTION] P43357; O00154-4: ACOT7; NbExp=3; IntAct=EBI-5651459, EBI-12007918; P43357; Q8IXM2: BAP18; NbExp=3; IntAct=EBI-5651459, EBI-4280811; P43357; Q9BQE9: BCL7B; NbExp=3; IntAct=EBI-5651459, EBI-2560588; P43357; Q9BW66: CINP; NbExp=3; IntAct=EBI-5651459, EBI-739784; P43357; O00471: EXOC5; NbExp=3; IntAct=EBI-5651459, EBI-949824; P43357; P42858: HTT; NbExp=6; IntAct=EBI-5651459, EBI-466029; P43357; A0A0C4DGT3: IQSEC1; NbExp=3; IntAct=EBI-5651459, EBI-12064916; P43357; Q86VH2: KIF27; NbExp=3; IntAct=EBI-5651459, EBI-7950718; P43357; Q9Y333: LSM2; NbExp=3; IntAct=EBI-5651459, EBI-347416; P43357; P49585: PCYT1A; NbExp=3; IntAct=EBI-5651459, EBI-2563309; P43357; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-5651459, EBI-6257312; P43357; P06702: S100A9; NbExp=3; IntAct=EBI-5651459, EBI-1055001; P43357; Q96FJ0: STAMBPL1; NbExp=4; IntAct=EBI-5651459, EBI-745021; P43357; Q13263: TRIM28; NbExp=3; IntAct=EBI-5651459, EBI-78139.; [TISSUE SPECIFICITY] Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas. {ECO:0000269|PubMed:8113684}.; [PTM] Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. {ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:31267705}.; [CAUTION] In vitro experiments measuring cell viability in melanoma cell lines used siRNA specific for MAGEA3 and MAGEA6. {ECO:0000269|PubMed:17942928}. |
| Source Db |
UniProtKB: locus MAGA3_HUMAN, accession P43357;; class: standard.; extra accessions:Q6FHI6; created: Nov 1, 1995.; sequence updated: Nov 1, 1995.; annotation updated: Oct 12, 2022.; xrefs: U03735.1, AAA17446.1, U82671.5, CR541767.1, CAG46566.1, CR541774.1, CAG46573.1, AK292384.1, BAF85073.1, BC000340.2, AAH00340.1, BC005963.1, AAH05963.1, BC011744.2, AAH11744.1, BC016803.1, AAH16803.1, BC017389.1, AAH17389.1, JC2361, NP_005353.1, XP_005274733.1, XP_006724881.1, XP_011529462.1, XP_011529463.1, 1QEW_C, 4V0P_A, 5BRZ_C; xrefs (non-sequence databases): CCDS:CCDS76045.1, PDBsum:1QEW, PDBsum:4V0P, PDBsum:5BRZ, AlphaFoldDB:P43357, SMR:P43357, BioGRID:110276, DIP:DIP-44886N, IntAct:P43357, STRING:9606.ENSP00000473093, ChEMBL:CHEMBL4662941, iPTMnet:P43357, PhosphoSitePlus:P43357, BioMuta:MAGEA3, DMDM:1170857, jPOST:P43357, MassIVE:P43357, MaxQB:P43357, PaxDb:P43357, PeptideAtlas:P43357, PRIDE:P43357, ProteomicsDB:55619, Antibodypedia:30766, DNASU:4102, Ensembl:ENST00000370278.4, Ensembl:ENSP00000359301.3, Ensembl:ENSG00000221867.9, Ensembl:ENST00000598245.2, Ensembl:ENSP00000473093.1, GeneID:4102, KEGG:hsa:4102, MANE-Select:ENST00000370278.4, UCSC:uc033faf.1, CTD:4102, DisGeNET:4102, GeneCards:MAGEA3, HGNC:6801, HPA:ENSG00000221867, MIM:300174, neXtProt:NX_P43357, OpenTargets:ENSG00000221867, PharmGKB:PA30547, VEuPathDB:HostDB:ENSG00000221867, eggNOG:KOG4562, GeneTree:ENSGT00940000164672, HOGENOM:CLU_039582_1_2_1, InParanoid:P43357, OMA:HEWALRD, OrthoDB:1195799at2759, PhylomeDB:P43357, TreeFam:TF328505, PathwayCommons:P43357, SignaLink:P43357, SIGNOR:P43357, BioGRID-ORCS:4102, ChiTaRS:MAGEA3, EvolutionaryTrace:P43357, GeneWiki:MAGEA3, GenomeRNAi:4102, Pharos:P43357, PRO:PR:P43357, Proteomes:UP000005640, RNAct:P43357, Bgee:ENSG00000221867, ExpressionAtlas:P43357, Genevisible:P43357, GO:0005783, GO:0005634, GO:0089720, GO:0042826, GO:0010507, GO:0043154, GO:1902236, GO:0010955, GO:0000122, Gene3D:1.10.10.1200, Gene3D:1.10.10.1210, InterPro:IPR037445, InterPro:IPR021072, InterPro:IPR041898, InterPro:IPR041899, InterPro:IPR030097, InterPro:IPR002190, PANTHER:PTHR11736, PANTHER:PTHR11736:SF60, Pfam:PF01454, Pfam:PF12440, SMART:SM01373, SMART:SM01392, PROSITE:PS50838 |
| Sequence |
mpleqrsqhckpeegleargealglvgaqapateeqeaasssstlvevtlgevpaaespdppqspqgasslpttmnyplwsqsyedssnqeeegpstfpdlesefqaalsrkvaelvhflllkyrarepvtkaemlgsvvgnwqyffpvifskassslqlvfgielmevdpighlyifatclglsydgllgdnqimpkaglliivlaiiaregdcapeekiweelsvlevfegredsilgdpkklltqhfvqenyleyrqvpgsdpacyeflwgpralvetsyvkvlhhmvkisggphisypplhewvlregee |
|
