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| Record Information |
| Record ID |
61 |
| Pubmed ID |
30088198 |
| SNP |
DQB104 |
| Gene ID |
3119 |
| Protein ID |
P01920 |
| Vaccine Adverse Events |
chronic hepatitis B |
| Vaccine |
Hepatitis B recombinant vaccine |
| Gene Name |
HLA-DQB1 |
| Official Symbol |
major histocompatibility complex, class II, DQ beta 1 [Homo sapiens (human)] |
| Aliases |
CELIAC1, HLA-DQB, IDDM1 |
| Other Designations |
HLA class II histocompatibility antigen, DQ beta 1 chain; MHC class II DQ beta chain; MHC class II HLA-DQ beta glycoprotein; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1 |
| Chromosome |
6 |
| Location |
6p21.32 |
| Annotation |
Chromosome 6 NC_000006.12 (32659467..32666657, complement) |
| MIM |
604305 |
| DNA Sequence |
>NC_000006.12:32659467-32666657 Homo sapiens chromosome 6, GRCh38.p14 Primary Assembly
TTTAGACTCAAAAATAGTATTTTTATTGCTGGTTATGCTTTCTTAAAAATAAAAAATATTCTTGATCGAT
GTGACTTTCCAGAATGTTTGAAACACCAGTGACCAAGGATCACTATATATGTCTCCAAACAATTCTACCA
TGCTTATTTACACAGCACTCACCAAACCAGAAGAGAGGCTGGGATATTCTAAGGCCAATGCACTGAGCAT
CAGTATTAAAGAACCATGAATGATGCGACAATTGAATTATTTTCTACCTCCTCTGCCCACCCTTACTTCA
CACCCCAAAATGCTTTCAGTGTCTTTTCAAGGTACAATCCTCCTTCTGGCCACAGGTTTGCTGGGTCACC
TCAAGGGATGTTCCTTCATTCTGCAGTGATTTCCTGCCTCTTCTCAATTAAGAAAGTTCAGAATACAGAT
AACTCAGGATCATGTTTAATTATGTAAAAAAGCTCTAAAGTCAGGTAATGTTTTTCATGTGCTTCTCTTG
AGCAGTCTGAGGAAAGAATAGAAACAGAAACCCCTTGGGACCTGAGTAGACGCAGCTGGCCATGCACAGG
CAGAGGCTCTGGGTCAGTGCAGGAAGCAGAGTCACAGCCAGCGCCTTGGGGTGGGGATGAAAGGAGATGA
CCTGGTGGCTGCGTGACAGCCACTGTAGGACTTTGATCTCAGGGGGACAAGCTGACACAGGCAGCTGGGA
ATTCTGGGCAGGCATAAGCAGGCATCACAGAAGAGTGATAACCAATCCTAGTTAAAATAGTCTCAGGAGT
CAGTGCAGAAGCCCTGGAGAAGAGAGAAGAGCATTGATCAGCACAGGGTATCCTGGTGGGCCTGCCATCT
CCCCCACCCTTCAGGGGCCCCCTGCAGCTTCAGACAGAGAAAGTTGAGGTCCAGGGTGTATTGTCATCAC
CTCCCCCAAGATCTGTGCAAAGGTGAAATCAGCTCATGAGGACACAGAACTTCAGCTTGATGCAGATGTG
TGGGAGGTGGGGAACAGCTGTTATTCTTCTGGGGAATATGAAGGGTTCAGTCTTTTTAGGAAATTGGATG
ATATCTCTTCCCGACCACTAGCAGCCTCTTTCAGTCACTGGAAAATGCTTACAGGCAGTAGCCACCATCA
TGTGGCACAAAGTGGGCATCATCCTAGTGTCTAACATTTAAGCTGTGGTTCTGGCTCCACATTTCACAAG
AAGATGCCACCAAAGTTAAGGCTTGGTTCTGGGGAACAATGTCTGGAGATTCCTAGAAACTGGCAAACTT
CTCCCCTAAGTCTTGATCCTCATAGCAGCAAATAGGCCATGAACATGGACCACTGTGGTCAGGTACACTC
AGCTCATGCTCTTCCCTCTTATACCTGTGCCTCCCCACACTGGATCATGGCTGAAATATTACCTGCTGGT
GGAGGCCCTTGAGGTCTTACAAAAGGAAGTTATGCAGAGAAAGGTCTCATTACACAAACAGCCACTCTCT
CACCCCAAAGGAAAATGACACACATGACTTAGAGTTACATTCTCTTCCCACCCATGTTCTTCCAGGCCTT
CAGCACCCTAATTTAAAATCCCCTAAAACAAAGGAAATTGTCACTAGAAAGAAAGGAAGCTGAGGCTCTG
ACCCTCTTAATGGAGGAAGCTTTTGGAAAGGAGCCAGTGAGACAATGATGAATGGTAAGGATGCCCTGGA
ATAAGCTCTATCAGTCAGCTCTGTGACAGCGCTACCTTTCAACCAGTAAAATCAGATTCCAATGCCTCCT
CCCATCTTGTCCTGTCTCCTCGCACTTCTTCTCAGGGTCAGGAGGAAAGAGCTAATCTACAGACAGGACC
ACTCTGAACAGAGGGTCTGGGTCACAGCCCATCTTCCCCTTTTCCCCTGGGGTTCCTCACCTTTCTGACT
CCTTTGACGGATGATAAGGCCCAGCCCAAGGAAGATCAGCCCCAGCACGAAGCCTCCAACGCCACTCAGC
ATCTTGCTCTGGGCAGATTCAGACTGAGCCCCTAAAGAGCAGAACTGAGTGTCTGTGTTTGTCCCCACAC
CCCATAGCATCCCTGCTGAGGAGTTGAAGTCCAGTCTGAGGTGCAGAAGGTGAAGGCATCAAAGGAACCT
AGTTCTCCATTCAGACCACCCCTAAGGAGGGGAAAGACCAGCCAATAGGTCCTTGGATACAGTGAATAGG
TGAGAGAGTGGGGAAGCAAATCTCTGCTCTTCAAGAACTCATCCATAACCTTAGACCCTAAGATCCCAGT
CACCAGCCCTAAGAATCAGTCCCTCAGAGCTATCAGGACTGGGATTCAGAGCAACAGTATGTAGAGTAAT
TTCCCTAGCATCTGGAAAGGTGATGAGACCAGGATTCTTCTGATGCACTTGCCATGGAGCAAGAGGTGCT
CTAGTCTCCTGTGATTCCCAGCTCAGTAGTGACATCAGGGATAAGAGATGGGAAGGAATGGGTCAGAAGG
AGCTCTTTGTCTTGTGGGCCCATAGTAACAGAAACTCAATATCCCCTTACGCCACTCCACGGTGATGGGG
CTCTGGAGGCTGGGGTGCTCCACGTGGCAGGTGTAGACATCTCCACGCTGGGGAGTCATTTCCAGCATCA
CCAGGATCTGGAAAGTCCAGTCACCATTCCTAATAAGGGGGGTGGACACAACGCCGGCTGTCTCCTCCTG
ATCATTCCGAAACCACCGGACTTTGATCTGGCCTGGATAGAAATCTGTCACCGAGCAGACCAGCAGGTTG
TGGTGGTTGAGGGCCTCTGTCCTGGATGGGGAGATGGTCACTGTGGGCTCCACTGAGGGCAGTAACAGAC
AGGAAAAGACATAGGAGTGAGATGTGAGAACACACACCACGTCTACCATGAGGAAGGATCCCTCCTTGGA
CCAGAGTGGAAAGATACCTGGAGTCGAAGTCTTGGATTAAGGTTCATTCAACAAATATAAATTTGACAAT
CACTGAGAATTCAAAGATAAATAACATACTATGGTCCCTGCATTTATAGAATGTGCAATCTAGTAACAGA
CAGCAAAAAACAAAAAGAATGTTATTTCAAAAGTTTGTAATATTTGAAAAAAAAGTAGAATGTTATTTCA
AAAGTTTGTAATATTTGAAAAAAAAGTAGGCAGGCCTTCAAAACAAATAACCCTTGATCAAACATCATGT
TTGTCCACAACTCAATTCCTTTATCTTCTCAGATTGCTGCTCATAGTAAAAAAAATGACACATCTTTCCC
CGCCTCTTTTACACATCTCATCCTTTCCTTTTAGGCCACTTTATCACATTTCCTTTATTCTCTTAGTGTG
AAACTATAGCAAATATTTAATGTGTGCTTTCTTTATTTAGTAATATGTTCTCTCATTTTCTTTTTTTCCT
TAATTTCTTTTTAACGCACAAGTGAGTTTAATTACTAGCTGTCTACCCTACTCCATTTCCTTGCTATTGA
CAATTACTTTCTTGTTCTGAAATCAGACATTATCGTGTATGTTCTCCACAGAAAATATTCTGAGATCCGT
GCAGAGGTCGGCCTGGGCTAATGAGCCTGTAATGTGAACATATACATATAACTGGGATTTGCTGAGGTCA
GCAGGTGGCACCCCAATTAAATGGCACTCTTGAGCCATCATCCGGAAGGAATCATGGTTTCTGCTTGGAC
TTGAACTTTTCTTTAGGTTCTCCTTCCTGGAGGCCAACTGAAATCAGAGTCAGCTATGTGGCCTTATAAG
ATTTGTTCATCTTCAACAGACTGGGAGTAAAAATAGAGGGCACAAATTTATGAGAAAAGATGATAAAATA
AATTTTATGGAAATAAAACTGAAATAGCAAAAATATAAGTACTTGCTGGCATTAGGATGTGAGTCAAAAG
AAGGCAAGGGAGTGTAAAGCAAACTAAAAGTTTTGTGAACCTGCATAGATAACACCGGGGTCAGACTAGG
GATTGATTAATCATGAATTTTCAATGCCGCATTAACACACAGAACAAACAGGAATAGACTCATTGCTGCT
TCTGGTCAAAACTGGCTTTAACAAGGCCTTACATCCCTTAGACTCTACATATGTGTAGTGAGGAACATAA
GAATGTTGTGTACTTTGGGAGGCTTAAGATCTTGGTGAGTAATTGTGGGCTGATTACTTAAAGTGTTTAT
CATGTACCAATATTAGGATATATAAAGTGGTGATGCTAATCTCTAATGCACAGGTAGCTGTGAGATTAAA
TGACATAACATAGATGGTATTTGATAAGGCAACTGTCTAGAAATAAGTGCTTCCTGAATGGGTAAAATTG
ACTTTCAGAATGTTTATTCCTGAAGTGGATAGTGATGGGGGGGAGGGGATAACCTAGGCCAAAAGCAACC
TGAAACTATTTTTATCCAATAATTTAATAGCTTCAACCTATTTATTCCCAAACTTCTGATCTTTGCATAG
TGCTATTTGTTCAGCTTTTCTAAGAAATTAAAACTCTGCCTTACAACATCATTCAAGCATTGTTTTTATT
TTTAGCAAACACATTTTCCTCAGACTTTGTATTCACAAATTCTATTAAGATCCAAGTCAGTAAGAGTTTA
CTTGAAAGCATTAAGCAAAATGTTAGAAAATAATTGATAAAGTTCATTTGTAAGCCTCTGTTTTTTTCTT
GAACCTAACTGGATTGGCAGCTGAGTACATTTATTCATGAATTTAACAGAAGATCATTGAGCTCACACCA
CATACCAGTCAATGTGTCAGGTACCAGGCATGCAATAATTAAACAGTCTCTCGCCTCAAAGATCTCCGCC
ATTAGTGGTAGCCATTTAAGAAAACAGAATTACGATGAATAATGATTTGAAGCCAAAAAGTCAAAATATC
TTATTTCGCAACTGTAATTGCTGGATGCCCTGCGCGCAGCTGTGGGGCAGCCCTAACTCCACCAGGCCAA
GCCTGAAGCTTCCTGCGGCGCAAGCTGCGCACGTGGGCCTTGCTGGGTGGGGCAGTGCTAGCGAGGCCGG
CGGGCAGGGGAAGAGGGTGGGCACTGGGGGCAGAGAGAACTGCTTAGCGAAGGTAAGGTACGAGGAGGCA
AACACATAAGGCACGAGGCGAGAAACGTGCAGAGCGGAGGACGAGGCCGACGGACGGGGAGGCTGGGGGG
GACACTAGGCAGCCTGGCCAACTCTGCTTGTCCCCCTGCTCTGCCCTAGGTCCCCGCCCCTCCGATGCAC
CTGCCCCCACCACCCCGCCGCCGCCTCCTTTCCCCTGGGGTGGAATGAACTGGGCTCAGATTTCAGAGAC
CTCGCCCCCATCGCCCCTCCCGGCACAGAAACTCGGGGTCTCGGCCAAGGGTGGGCCTCACGGAGGGGCG
ACGACGCTCACCTCTCCTCTGCAAGATCCCGCGGAACGCCACCTCGTAGTTGTGTCTGCACACCGTGTCC
AACTCCGCCCGGGTCCCCTCCAGGACTTCCTTCTGGCTGTTCCAGTACTCGGCATCAGGCCGCCCCTGCG
GCGTCACCGCGCGGTACACCCCCACGTCGCTGTCGAAGCGCGCGTACTCCTCTCGGTTATAGATGTATCT
GGTCACAAGACGCACGCGCTCCGTCCCGTTGGTGAAGTAGCACATGCCCTTAAACTGGAACACGAAATCC
TCTGCGGGGAATCACCGGCCGGTCAGTCAGGCCCCAGCCCGGCCGCCCCCGCAGCCGCCGCCCTGACCCG
GCCTGGAGCTGTGGAACCGCCCGCGCGACCTCCAGTTCCCGCCCGCCCGTGCCTGGCGCTCCAGACCTGG
GATCCTCCCGGCGGCTCTGCCCAGCTCTGCCCGCCTTCTTTGCGGGCTTCTGGAATCTGCCTTCCTACAT
CCAGGAAAGGGAGGAAAGCCCTGTCCCTGCCTGAGCCTGTGAACCCAGCGAAGAGGCAGTCGGGCTGATT
TTACATGCACCTCTGCACTTAGAGGGATCAGGGCGTTCTCGCATGAAATCCCATTTTTCATGAAGCTCCT
GGATACCTCAGAGATAAAGTTATCCACATAAATCTGAGAGTTCAACGGAATGACGAGATAGGTCCAGGAA
TTAAGCCTGGCCTCGTTCTGACACGCGTATTCTCTTGGTCCCTGGGTAAAATACCTTCCTTCCCATGCCT
AGATTTACCCTCCCAAGTCCCGTTGAGGTTCACTCCCTTCTATGTTGGAAAGGACCTACACCTCTGAGTC
CTAGATAGAGACATTTATTCATGGAAAGAGCACAAGCTTTTGAATTTGATAAACTAGATTCCAATTAAAC
TGTGGCAGTCACCAGTTTGGGCAGGTTATGTAACAGAATATCCATATCACAAGTATAATTGTGTAAAAGA
AAATCATGATATCTACACACAGGATGTTAGAAGGAGTGAGAGAGAAGTTATATAAAGTATTGTTCTGTCT
GAAGTGAGTGGTTTCACAATATGTGTTATTTCCCTTCTTTACATCCTCCTTCCTACTAAATTCAGTCCAC
CATTAACTCGGGTCTCTGAATCCCACTCAAGTCACCATTTGCCCATAAATCAGTGAAACCCGAAGACTCC
CTCTCTGTGGTCAGCCAGTCAGCTTCCCTCAGCACCAAGATTTTGCCTCCACAAATGCTCCACTCGGTCA
GGAATAGAGACAAATTTTCCTCAAATACAGAGACTACAGACACCATTGCTGCCTCACATTTTCCAATGCA
GGATCTCATAATCCTAAGTCCAGGCAGTCTTGGGGCACGCCTAAATGACAAATCCTGCTGTGTCTTTGGA
GAAATTCATATCTTCAAAAATAACCCCATGCTCACTTTGTCCTATCGCTGGTAGTAAATGTACACTTTAT
CTCCTCTTTCTCTCCTCTCTCCTCCTCTTCCAGGCTTAAGCCTGTAGGATGGGGATTGGATTGTCCTCAT
CTCATCACTAAAAGATAAATGGGAATGCAACATAGCTTTCTTTCCCAAGAGAGAGGAAATGTTGATGAAA
GATTGTGTCCAAGATCATAGAGATCACCATCCCCCATACCCCAGCCCAAGGAGAGCCTGTTCCCAGAGTG
GCGGCTCTGGAGAGCAGCTGCCCTGCACTTACCGGGAGAGTCTCTGCCCTCAGCCAGTAGGGAGCTCAGC
ATCGCCAGCATCAAGGTGACAGTTGCTACCCGAAGGTCTCCGGGGATCCGCAAAGCCTTCTTCCAAGACA
TAACTGAGACGAAGGGAAAAGCAGTGGTAGTCAACACAGCTCGGACCTGAT
|
| Protein Name |
DQB1_HUMAN |
| Length |
261 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
03-AUG-2022 |
| Create Date |
21-JUL-1986 |
| Definition |
RecName: Full=HLA class II histocompatibility antigen, DQ beta 1 chain; AltName: Full=MHC class II antigen DQB1; Flags: Precursor |
| Primary Accession |
P01920 |
| Accession Version |
P01920.2 |
| Other SeqIDs |
sp|P01920.2|DQB1_HUMAN,gi|290457643 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Mar 2, 2010 this sequence version replaced gi:74739599, gi:74739651, gi:74739714, gi:74739717, P01918.1, P01919.2, P03992.2, P05537.1, gi:74739741, gi:74739742, gi:74739748, gi:121940129, gi:74739765, gi:121940216, gi:121940764, gi:74739933, gi:74739988, gi:74754534, gi:74740007, gi:121941628, gi:121941702, gi:74754550, gi:74740085, gi:74740086, gi:74740090, gi:74740091, gi:74740092, gi:74740093, gi:74754569, gi:121942322, gi:121943209, gi:82066185, gi:74740626, gi:74741001, gi:74741479, gi:74755527, gi:74755528, gi:74748054, gi:74757241, gi:74748151, gi:74748395, gi:74749748, gi:74749993, gi:74750604, gi:74750862, gi:74751330, gi:74751338, gi:74751343, gi:74751492, gi:74752211, gi:74752871, gi:74753162, gi:74753459, gi:74753460, gi:74753461, P01920.1.; [FUNCTION] Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.; [SUBUNIT] Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. {ECO:0000269|PubMed:11376336, ECO:0000269|PubMed:14769912, ECO:0000269|PubMed:15020763, ECO:0000269|PubMed:17629515}.; [INTERACTION] P01920; P01909: HLA-DQA1; NbExp=8; IntAct=EBI-1038012, EBI-713389.; [SUBCELLULAR LOCATION] Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.; [POLYMORPHISM] The following alleles of HLA-DQB1 are known: DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, and DQB1*06:39. The sequence shown is that of DQB1*03:01.; [POLYMORPHISM] DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02).; [POLYMORPHISM] DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy. DQB1*06:02 has been found to be present in most of the narcolepsy patients. As well 98% of the patients with an HCRT deficiency are positive for DQB1*06:02.; [SIMILARITY] Belongs to the MHC class II family. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=AAC64403.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAJ57391.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}. |
| Source Db |
UniProtKB: locus DQB1_HUMAN, accession P01920;; class: standard.; extra accessions:A1KR27,A2RPH3,A4Q9R4,A4USG2,A4USG5,A6N8I7,A9YQA0,B0S7Y7,B1A0K6,B1GXI3,B3VLT3,B5BLN7,B7VU69,C0MQ34,C0MQ35,C8ZL52,C8ZLJ8,C8ZLJ9,C9DRQ3,O19708,O19713,O19724,O62861,O78046,O78221,O78223,O98034,O98201,P01917,P01918,P01919,P03992,P05537,P79482,P79526,P79544,P79551,Q08GC8,Q09035,Q0E4V9,Q1M312,Q29731,Q29877,Q29884,Q29915,Q29966,Q2P9N3,Q2QK85,Q30061,Q30075,Q30076,Q30080,Q30081,Q30082,Q30083,Q30084,Q30089,Q30095,Q31633,Q38I47,Q45UE3,Q4QZB5,Q53I44,Q564J6,Q5G841,Q5ISH1,Q5ISH3,Q5W1E1,Q5Y7G8,Q643R4,Q6B9X1,Q70VH8,Q7YP69,Q8HWH0,Q8MH58,Q8SNB4,Q8SND1,Q8SP70,Q8WMA3,Q9BD17,Q9MYH2,Q9TPA9,Q9XRY6,Q9XRY7,Q9XRZ2; created: Jul 21, 1986.; sequence updated: Mar 2, 2010.; annotation updated: Aug 3, 2022.; xrefs: K01499.1, AAA98746.1, K02405.1, AAA75521.1, X03068.1, CAA26872.1, M17564.1, AAA59765.1, M29613.1, M29616.1, M16996.1, AAA59770.1, M20432.1, AAA59769.1, M60028.1, AAA59755.1, X96420.1, CAA65280.1, U92032.1, AAB91991.1, AY663393.1, AAU87973.1, AY663394.1, AAU87977.1, AY663397.1, AAU87986.1, AY663409.1, AAU88017.1, AY663404.1, AAU88002.1, AY663410.1, AAU88020.1, AY663412.1, AAU88027.1, AY656681.1, AAV71028.1, AY656682.1, AAV71029.1, AY656683.1, AAV71030.1, BX927168.11, CR753846.4, CR933859.5, BC012106.1, AAH12106.1, M25327.1, AAA59677.1, U66400.1, AAB51698.1, U83582.1, AAB41231.1, AH002887.2, AAA59762.1, M26042.1, AAA36270.1, M33907.1, AAA52672.1, L34096.1, AAC41964.1, L34098.1, AAC41966.1, L34101.1, AAC41969.1, L34103.1, AAC41971.1, L34104.1, AAC41972.1, L34105.1, AAC41973.1, L34106.1, AAC41974.1, L34107.1, AAC41975.1, AF195245.1, AAF28315.1, L42626.1, AAA85335.1, X76553.1, X76554.1, M59800.1, AAA64235.1, M14189.1, AAA36268.1, AY672649.1, AAT77952.1, M17207.1, AAA59697.1, Z49215.1, AY026349.1, AAK01944.1, AF091305.2, AAC64403.2, U77344.1, AAB19215.1, FN256435.2, CAX62164.1, CAX62165.1, AM400970.1, CAL47037.1, AM421131.1, CAM07104.1, EF484936.1, ABO87661.1, EF484939.1, ABO87664.1, EU275158.1, ABY26531.1, AM944346.1, CAQ16179.1, FM200854.1, CAR31119.1, AH013029.2, AAP93137.1, EU770203.1, ACF16333.1, FM955320.1, CAW24712.1, FN552709.1, CBF35736.1, FN552710.1, CBF35739.1, X86327.1, D78569.1, BAA11413.1, AF439338.1, AAL35222.1, AF384556.1, AAM53072.1, DQ026226.1, AAY89656.1, AY762968.1, AAV97949.1, AM181332.1, CAJ57391.1, AM691798.1, CAM88661.1, AM259942.1, CAJ90956.1, U39090.1, AAB02681.1, AJ003005.1, AJ012156.1, CAA09929.1, AJ290396.1, CAC27418.1, AF469118.1, AAL77085.1, AF479569.1, AAM09472.1, AJ535315.2, CAD59445.2, AF181983.2, AAD54423.2, AY733062.1, AAU33811.1, AJ854065.1, CAH69441.1, AJ964903.1, CAI79639.1, AB211231.1, BAD95610.1, DQ114427.1, AAZ20753.1, DQ227421.1, ABB05231.1, AM403489.1, CAL48285.1, AM490069.1, CAM32717.1, EF622510.1, ABR24117.1, EU410617.1, ABZ89500.1, GQ422610.1, ACV66342.1, FN550110.1, CBE66554.1, AF087939.1, AAD39697.1, AY094140.1, AAM14401.1, AJ001257.1, CAA04631.1, U39086.1, AAA93181.1, AJ965439.1, CAI84643.1, AF112463.1, AAD23990.1, AF112464.1, AAD23991.1, M94773.1, M65042.1, AAA36241.1, M25025.1, AAA59793.1, HLHU1C, A35055, HLHUDB, B32527, B37044, HLHU2C, F30575, I54480, I68732, I72482, S46648, NP_001230891.1, NP_002114.3, 1JK8_B, 1S9V_B, 1S9V_E, 1UVQ_B, 2NNA_B, 4GG6_B, 4GG6_D, 4OZF_B, 4OZG_B, 4OZG_D, 4OZH_B, 4OZH_D, 4OZI_B, 4OZI_D; xrefs (non-sequence databases): PDBsum:1JK8, PDBsum:1S9V, PDBsum:1UVQ, PDBsum:2NNA, PDBsum:4GG6, PDBsum:4OZF, PDBsum:4OZG, PDBsum:4OZH, PDBsum:4OZI, AlphaFoldDB:P01920, SMR:P01920, BioGRID:109364, IntAct:P01920, MINT:P01920, STRING:9606.ENSP00000364080, TCDB:9.A.75.1.1, GlyGen:P01920, iPTMnet:P01920, PhosphoSitePlus:P01920, BioMuta:HLA-DQB1, DMDM:290457643, jPOST:P01920, MassIVE:P01920, PeptideAtlas:P01920, PRIDE:P01920, ProteomicsDB:51513, ABCD:P01920, CPTC:P01920, DNASU:3119, Ensembl:ENST00000399088.8, Ensembl:ENSP00000382038.4, Ensembl:ENSG00000231286.7, Ensembl:ENST00000413089.1, Ensembl:ENSP00000396539.1, Ensembl:ENST00000416192.6, Ensembl:ENSP00000410107.2, Ensembl:ENSG00000233209.6, Ensembl:ENST00000419914.6, Ensembl:ENSP00000402865.2, Ensembl:ENSG00000225824.8, Ensembl:ENST00000422950.1, Ensembl:ENSP00000414079.1, Ensembl:ENST00000424806.1, Ensembl:ENSP00000410330.1, GeneID:3119, KEGG:hsa:3119, UCSC:uc011hep.3, CTD:3119, DisGeNET:3119, GeneCards:HLA-DQB1, GeneReviews:HLA-DQB1, HGNC:4944, MalaCards:HLA-DQB1, MIM:604305, neXtProt:NX_P01920, Orphanet:703, Orphanet:930, Orphanet:2073, Orphanet:83465, Orphanet:555, Orphanet:243377, Orphanet:802, Orphanet:477738, PharmGKB:PA35068, eggNOG:ENOG502RYBQ, InParanoid:P01920, OrthoDB:1186163at2759, PhylomeDB:P01920, PathwayCommons:P01920, Reactome:R-HSA-202424, Reactome:R-HSA-202427, Reactome:R-HSA-202430, Reactome:R-HSA-202433, Reactome:R-HSA-2132295, Reactome:R-HSA-389948, Reactome:R-HSA-877300, SignaLink:P01920, SIGNOR:P01920, BioGRID-ORCS:3119, ChiTaRS:HLA-DQB1, EvolutionaryTrace:P01920, GeneWiki:HLA-DQB1, GenomeRNAi:3119, Pharos:P01920, PRO:PR:P01920, Proteomes:UP000005640, RNAct:P01920, Bgee:ENSG00000231286, GO:0030669, GO:0030666, GO:0010008, GO:0012507, GO:0000139, GO:0071556, GO:0005765, GO:0016020, GO:0042613, GO:0005886, GO:0032588, GO:0030658, GO:0023026, GO:0032395, GO:0042605, GO:0002250, GO:0019886, GO:0006959, GO:0006955, GO:0002503, GO:0050870, GO:0050852, Gene3D:2.60.40.10, Gene3D:3.10.320.10, InterPro:IPR007110, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003006, InterPro:IPR003597, InterPro:IPR011162, InterPro:IPR014745, InterPro:IPR000353, Pfam:PF07654, Pfam:PF00969, SMART:SM00407, SMART:SM00921, SUPFAM:SSF48726, SUPFAM:SSF54452, PROSITE:PS50835, PROSITE:PS00290 |
| Sequence |
mswkkalripgglraatvtlmlamlstpvaegrdspedfvyqfkamcyftngtervryvtryiynreeyarfdsdvevyravtplgppdaeywnsqkevlertraeldtvcrhnyqlelrttlqrrveptvtispsrtealnhhnllvcsvtdfypaqikvrwfrndqeettgvvstplirngdwtfqilvmlemtpqhgdvytchvehpslqnpitvewraqsesaqskmlsgiggfvlgliflglgliihhrsqkgllh |
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