|
|
| Record Information |
| Record ID |
6 |
| Pubmed ID |
32219501 |
| SNP |
|
| Gene ID |
201633 |
| Protein ID |
Q495A1 |
| Vaccine Adverse Events |
injection site reactions and edema of the extremities |
| Vaccine |
cancer vaccines |
| Gene Name |
TIGIT |
| Official Symbol |
T cell immunoreceptor with Ig and ITIM domains [Homo sapiens (human)] |
| Aliases |
VSIG9, VSTM3, WUCAM |
| Other Designations |
T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9, VSTM3; Washington University cell adhesion molecule |
| Chromosome |
3 |
| Location |
3q13.31 |
| Annotation |
Chromosome 3 NC_000003.12 (114294028..114310288) |
| MIM |
612859 |
| DNA Sequence |
>NC_000003.12:114294028-114310288 Homo sapiens chromosome 3, GRCh38.p14 Primary Assembly
ACATCTGCTTCCTGTAGGCCCTCTGGGCAGAAGCATGCGCTGGTGTCTCCTCCTGATCTGGGCCCAGGGG
CTGAGGCAGGCTCCCCTCGCCTCAGGTAAGGCCTGAAACCCAGCAGAGCAGCAGGGAGGAAAAACAAGGC
TAAGCTTGGTTGGAGACTTGGGTGCTTGTGTAGGGAAGACTCCAAGAGCATGCCACAGCTGCTTGAGAGA
AAGAAATTGCAACTTTTAGAGTCCTGTGTACTCTTATTTAAGAAAGGACAATCTCTGAGAATGAGGTGGG
GTTCTGTTTTTGGTGGCAGATGAAGGACTTTGCAGACTTCCGGGGTTGGAGGAGCCTGACTGGCCAGCAC
AAGAAGGAGCAGGAGAAGAAGAAGGGCTGGGCAGGAGGCATTGCCAGTTTGCTTTTAGAAGCTCATTCCT
GCTCCAGCTTCTTTTCTGTTGCCTTTCAGGAACTTTCCAGGAAAACATTATAAGTTCTCTGTGAATTGAA
AATGTCTTTTTCACAGATTCCAGAGGTTCTACCACTAGAGACTGATTTTTTGTTAAATTTATTTCTTCTA
TATTAAAAATCAGAGTCAAATATTTCTGAGGGAGGGGAACACAAATATTTAAAAACTGTGGTATAAATTA
GTTTTTATGTTGCCTTCTGAACTATCTGAGGATGGAGATGTGCCCAGGGTTGCTGGGGAGAGGTTAAGTG
CTGAGAGGGTGGTTATGCCTGGGAGAAGCAGGGTTTCCTGCTAAGCTTCCTTTGCTATTGGATTTCTTGG
CTTTCCTGAAGGTTTTTTCAGGCACTGCAAATGACAATCAACCAAACAGCAAGGTTTTATTTCAAAGGAT
AATGCATCCAGCATAGAACTAGGCCGCAGGAAGAAACATAAAAACAAAACAAAATAAAAACAGAAGAGGT
GGTATCAGCTGACAAGGGCTTATATTCTAAGTGGGTAGACAAAATAGGCCTACGAAAATAACAAGCTGGC
CATGAAGCTACATAGCAGAATATGCGAGGGGGCAACGTGCTAAGTTGTGTAGTCATAAGCCAGGCATTTA
GTAAGGTGCTAATTATACAATACAGGCAGTGAATGTGAAAGGAAAAGGGAGGTTGAGATGGGCTGAGGTC
TTCTAGGAGGCGGGGAGGGAGTGCAGCCTTGACAAGCCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAA
GTCAGCTCTGGAAGCATAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGATGTGT
GGAGAAGGGTGAGAAGACTGGAAAGACAACCTGAATGGGGGACTGGGAGCCTTGAATAACAGGCATGGAG
AGGAGCGTCTCTTGAAATGGAAGAAACAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGGATGGACT
GGAGAAACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTCTAGGAAGGTTGAAG
GCCAGCTGCTGACCCAGGACTCACATGTGCTTCGTCCTCTTCCCTAGGAATGATGACAGGCACAATAGAA
ACAACGGGGAACATTTCTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTCCACCACGG
CACAAGTGACCCAGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAATGCTGACTTGGGGTG
GCACATCTCCCCATCCTTCAAGGATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTG
ACCGTGAACGATACAGGGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGGAGAA
TCTTCCTGGAGGTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCTCTA
GCATAGAAAATGCAATCCTGAAACACTGCACAGCAGGGCTTCTCAATTCGGGATCACATTTGAATCACCT
GAGGAGATTTTAAATCATACTGATGCCGAGGCCTCACCCAGACCAATTCAATCAGAATCCCTAATAGCAG
AGCTAAACAAGGGTAAGGTCTAAAAGCATTTCCAGGTGATTCTAATGGGCAGCCAATACTGAGAACCACT
GTTCTTATGTAAGAAGCACATCTTACCTATATTTCCTAGGAAGACCAGTTGATGAGGTCATATGCAAAAG
TTCCCATTTATTGGTTTAGTATAATTGTGCAAATTAGAATTAACCCCTAAGTGTATAAAGAGTAGAGCTG
GTTAAAAACATAGCCTGTGCTAAGTTTAATTGTACAGTAATTTACATTTGTGTGGTACTTCCAAGTTTCC
CAAATGCCCTCATATTTGTTATCCACCTGTACATTTAAACCAATTCCCAGAGGTTAGAAAAGGATTCTTA
TCTTATCTGAGAGACAGTATAGCACCATGGTTAAAAGCTCAGACTCTGACACCAGACAGTCTGGGTGCAA
ATCCTGGCTCTGCTGTTGCCCTCAGACAGGATTTCTTAGCTTCTCTGTGTATCAGTTTTCTCATCTGTGA
AAGGAGGATGAATATAAGACCTTATGCGATGCTAATGTAGGATTAAATTCCCTACTACAAGAAAATGGTC
TTAGAACAATGCCTGGAACATGGTAAGTGCTGTATAAGTGTTAACTATTAGTATGATTCCCATTTGTTTG
ATGCAGGCAGAAGCTGGAGCTTGGAGTTGCTCAGAGTGGTAGAGCTGATTTTAACACAGATGTTTTTGTT
CTACTAAACTGCATCCTCAGAACTCCTATTTACTGCTGTCAGTTATGTTGAAGATTAAGTTATATGGTTG
CAAAATATGTGTAAACTGAGAAGATAAAAGGTTACCTTAAAGTTTCCTTTCAAATGTTACTTCTTTTTTT
TTTTTTTTTTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCAATCTCAGCT
CACTGCAACTTCCGCCTCCTGAGTTCAAGCGATTCTCTCCTGCCTCAGCCTCCTGAGTATCTGGGATTAC
AGGCACCCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTCTTCACGTTGGTCAGG
CTGGTCTCAAACTCCCGACCTCCAGTGATCTGCCCGCCTCAGCCTCCCAAAGTGTTACTTCTTAACTGAT
TTCACATAGGCCAAACAAAGACTGGTTAAGAGTTGAGGCTCTGGAATTGCACTGTCTGGGGTTGACTATT
GCAGTTGACCCCACGAAGTCTGGGTAAATTATGTACTTTTTTTCTCAGTTTTCTTGTCGATAAAATGTGG
CAAATAATTTCATGAGCTGATACAAGTAAGGTCTTACAACAGTGCTAGATAGGTAATAAGCTTAACTTCA
TAAGGGCTAGTTTTTATGCTATTTATTGGTTCATGGTTAGAGGAGGCCTGGGACAATAAGCAGGGCAGGG
GACCTAGATTCTGGCAAAGTAACCAAGTGATGGCCTTGACCATTCTGGGCTCTTTACCCCAGTGTCATAT
GCCAGAGGACCCATCACCAGACGGCAGGACCGGGAACAGGGAGGGAGTTCATCAGGCAGAAGGCCCCTGT
GGAGTGGTAGTACCAGCAACTGAAGACCAAATGGGAGCTATGTCTGGTTGCTAATCTCCAGGCCAGGCCA
TTCATGGAGATCGGTGGTCCTGACATGCACACTCCTCCCCAAGACCACAGTGGCACGGCTATTTCCCAGC
CTGAACCTGGGGAAATGAAGGTGCAAATTTCTTCTCTGTGGCTCATGGACCCCTGGGGAGAGAGATCAGA
AGATGTTCTATTGGACCCCTGTGCAGCCTCCCCACAAAGCCTGTATGTTTCCACCCTTTTGCCATTGCAG
ACTCCAGGGAACACCATTGGTCACTCGGCTCTTCCCTCTTGTTTCCCAAGTGGTCAGTTGCTTATGTGGA
ATGCAAACTCTCCTTAATTACTTGCATTAGCACAAACCCTGGCTTCTTTTTGAACCTAATCTCAAACCTT
AGTCCAAGTCCCTATCCTAATACTATCTGTAATATTTAAGCTATTCCTAACCTTAATGCTAAAATTGTAC
TTAACCCCAAAGTCAACCTGGTTAATAGGCAGAAGTTTTAAGTAACCCTTATACAGAGTCTGCCCCTTCC
CCACCCTGCATGTAGTGATGTCATGCTTACTCAGGGCTGCTTCTGTTTCAAAGACCTTGATATCTTTGTT
CTATGACCATAACTGTGAATGGAGACATTGGTGCTTTTATTTCAAACCAAAAATTCCAAATGAAATTGAT
ACATCTAATATCCCAAGTTCCACTCTGGTCCCAATTGTATCTCGAACTTATCCTTAAACCTAACCAAACT
CATTATCATAATCTTCCCTAAACCTCAACATGCTTTTCACTCCATCTATCTTCATCTGTCCCCAAGGTGT
AAGAGAACCCAGGCCTAACCCTGCCTCCAATCTGGCTCTGTCCCCAAACTGATCATATATCCTTTCCTGG
TTTTATGGATAGCCCTCTGCAGCCCCTCTTACCTGCTGCAGTGTGTTCTCTATGACCCCTGTGCTTTCCA
TCTGTCCTCTTTACTCCAGAGCTAACTGTATGGCTATGGCTAACCAGAAGCCGTCCTGGCCAACTGTGAC
TGAGTCCCTCAAGGCAGGAGGAACATGTTCTGGGGAATTTGAATTGTGCAGGCACCACCCTTGTCTTATG
GATTGGATTCCTAAGCCACCTTTTAGCAACCCAGACCCTTAGGTAGAGGGATGAGATGTGAGGCTTCTGC
TGCATCCTTTGAAGACTCCCCTGGATACCTGAGCCCTACCTGAGCTGCTGGGGCAGACTGGAAACCTACC
TACAGCGCAGCATGCATGGGGGTGATGGTGTTCTTTTTCTCACATTCTTCTTGGGTCAGATCTTACTCAT
CTCTTCAAAACTCCCCTCCTGCATCTTCTTGCTTCCACTTACATGTTATCTCTTAATGAAATGCACTAGT
TCATGATTTCACTTATGCCACAAATATTTATATTTACTGAGCATTCGCTATGTGTCAGATGCTGAGAAAA
CAGCAAAGGATAAGAGTCCAGAGCCTCATGCCCTCCAGGGTTTCACAGCCTAGCTGGAAATAAGTGTTAT
AGGCTTAAGGGAAAAGGTTACATACTTTTTTTCATTTTTGTAATTTAATGTTAACTTTATTTTAATTTTG
AATTAAATATTTTTATTGATATGATTTCATATTTGAAGTTCAATAAAAGAAAATATTCACTTTCTGAGTT
TTTTTCTGGAACTACTATTTGTTTCATTTCATGATTACCAAAAATGATTTTGTCAAATAGAAGAAACGAA
TGTTAAAATGACCTGCTCTGGTATCAAATATACAAGGTACACCACTGCTGAAAATATCAGTCATTGATTT
CATGATGGGCCAGATGGATACTCTGCTGTTCAAAGTGTTGGGCTTAAAGGCTCCAGTCCCATGGTTACAC
AAAGGGCTTGGCCAATCCTCCCCTCTCTGCCGTGAAGCTCAGGCTGCCCTGGGGAAATCAGCTTCACTTC
TGGCTTCTGCCACTCATCTCTGTTTTGTCCTCCCTCTAGTGGCTGAGCACGGTGCCAGGTTCCAGATTCC
ATTGCTTGGAGCCATGGCCGCGACGCTGGTGGTCATCTGCACAGCAGTCATCGTGGTGGTCGCGTTGACT
AGAAAGGTAATGGCTCCGGCTGCACACCGCAGTCATGGGCACCCCCACGTCTGGCACCCGGGTCCTTTCA
GGTTCTCTTTCCACCCAGAGAGAGACCCAGATGTGATCTTCCCGAGTGCTCTTTGTGCCTTTTTCCTGGC
ATTTGTTCTGCCTATTAGTGCAGTTATTTATGCTCTTCCGTTGTCCCTCTCATAGGGAGGGACCCCCTGG
ACAGCTGGACCTGTTTCCTACCCATCTTGCTGTCATTTGTAACTCCTGGTTTCTGCTTATCCCTTAAGCC
ACTGCTCTGAGAGTTTAATTTATCTACTATGATTTTGATGCATCGTGGGCATCTATATATGCTAGAGCTT
TCTGCACATTAGCTCTTTTGATTATTACAACTCTCTGGTAGTGCTAGGTTACCCAGCATGTCTGTAGAAT
GAGAAATAAACACTCCAAAAATGTAGGGTTAGGCCAGGAGCTGTGGCTCACACCTCAGAAGCCACAGATA
TGGCTGGTGCTATTGGGAAAGTCAATGATCTGTAATATTTTCATTTATGTGTTGGCTATCACAATAGACA
TAATTCCACCCACTCGGGAGACTGTGGCGGGAGGATCACTTGACTCTAGGAGTTCAAGGCTGCAGTGAGC
TATGACTGCACTCCAGCGTGGGCAACAGAGCAAGACTCTATCTCTAAAAAAAAAAAAAAATTGGTGGTAA
AGTGGGCATGGCAAGATCAGCAGGTTGTAAATCCTCTGTTTAGCTTAAGAGCTTATGTGGCTGAAAGAGT
AATGAATGGGGAATTGAAAGATCTAGTTTCTAGTTTTGGCACTGAGTGTATGCTTTTAGGAAAGTTACTT
AATCTTTCAAGGTCTTCATTTCCTTATATATAAAATGGGGATTTGTCTTAGTCTATTTTCTGCCGCTGTA
ACAGAATACAATTATTGGGAAATTTATAAAGAAAAGAAGTTTATTTGGCTCATGGTTCTGGAGGCTGGGA
AGTCCAGGAGCATGGTGTATTTGGCGAGGTTCATCCCACGGCAGAAGGCATCATGTGATGAGTGCATGCA
TGTGAGAGAGAGAGAGAAATGAGGCCAAATTCATCCTTTTAATTAGGAACTTACTCCCATGATACCTAAC
CCACTCCTGAGATAATGGCATTAATCCCTTCATGAGGGCAGATCTTCATGGCCTAATCACCTCTTAAAAG
CATTACCACTTAATACTATTACAATGGTAATTAAGTTTCCAACACATGGCCTTTTGGGGGACACATTAAA
ACCATAGCTGTATTATAATTCGGCTTACTCTATATCATAGAGTTGTGATGAACAAGTGGCATATTTCATG
TAAAATCTTTATAAATAACAAAGAATTATATCAGTGAAATTTATGTCATCAGCTACTGGTATTGATTGGG
AGGAGTGAAAGAATTTCCACTCCTTGTTTTGTCTGATCTCTTGGGCCCTTTAAGTCAGCTCAGCCCAGGT
CACCTTAATTCAAGTCACCACATAAATATTTTGGGAAACACAAGTTTGTAATTTCTACCTTTACCCCAGA
CCCTCCACCTGAGATCCTAACCCACTTTTCCTCCAACTCTAATTCCATTCAATTAACAACTCAGTTCTGC
AGCCTGGTTGAACTGCAGTGGCTGAGACATGGCTGGTGCTATTGGGAAAGTCAATGATCTATAATATTTT
CATTTATGTGTTGGCTATCACAATAGACATAATGAGGAAATGAACCCTCTATGGGAAGGTGAGGACAAGA
GAAATGATTGAATAGAGGGGGGAGGTGAAGAAGATGAAAGTTGATCTCTTAGCTGGGAAGGGAGCTGCTA
TGGTGGTTGGTGAACAGGTTCTCTGCTGTTAGCAGTGTCCTGATGGTCTGGAATAAAAGAATCAAAGGCT
CTTTAGAAGGAGCTGAACAACTTTTCCTGTTAAGGATTCAAGACTGGTTAATTTTCATTCTGGGCACCTG
GACTAACTTTGGTCATCTGGAGGGTAGAGAAAGAGAAAAAGGTGAAGAGACCTATTGAGTCCTGTTGCTC
CCTTTCTACAGTGTTTGATTCCCCAGCCCTCTCTGACATTTCCACTGCTTCCTGTGTAGTGTGGGTCCTC
TCTGCATCTTTCCTGTGCTTTGGATATAGTTGTCAGTCTTCTGTCTCTCTCTCCTTGCTCAAAGCATTTT
ATAGTTGCATTATTCAGGGTTCCAGCAGGGAACATGTAGTACTCAAACTGGGTTGTTTGAAGACAGTTTA
ATAATAGGATTTCCAGAAGTCTAGTAGGATGTAAGGACACCACAAGGAGGAGTAGCAAGGTGCTGTAACC
ATTCCTAGTTCTTCAAAGGGTAGGGGAGGGGCTAATTATTGGAGCCTGGAAGGAGAGAGTTATGTGGAGG
GGTCTCCTTCAGAAGTGCTGTAGTCTTTGCTGGAGGGTCACAACCAGTCCAAGGCCACCCTGCAGAAAGA
ACAAAGGGAACTACATACCCTCATCTCATTCCTCTCTCCATTCCCCTACTGTTGCTTTGCATTGGCTGAC
CTCAAACTTAGGATGGAGGATAAGGGGACTCATTGATGTAGTACATTTAGTACAGTCTTCATAGGGCACA
GAATAGGGTGGAGAAGGTTAGAGAGCAGAGCCAAGAGGCAAATGGCTGGTATCCATTCAAGTAGTGCTCA
TAGACATGAACACTGGACAAAGGATCTTGACTTTCCACAGGGTTGGCTGGCTTCAGCCTTCTCTCTTGTA
GTCTTGACCTCTTTTGATTATGTATGTAAGCAATACCCTTCTTGGCTGCCCAGCTGTATCTCTCCTGGGC
ACACTGTGCTCTATTAACCATTTTAATATTCCCATGGATCAGGCTTTCTTGGCTCCCATTGAAGTAATTA
CATCCATTTTGTTTCTTTAAGTGCTGCTATCTGTTCTGTACTATTTTGGGATCTCCTCATCCTCATTGCT
ACTAGGAATCCAGTTCTGTAAAAGCATCTCCTATTTTAGCCCTAGCCTATAGAGGAGAGATGCCACCAAA
CTTCTCAATGATGCTGGAGCTCCCCTAGCACATTCTTTTCCAGCTTAGTAAAAGGGATATTCTTTTTCTT
TTTCCTTTTTCCCCTTTATTGTTGCTATTATCTTAAGGGATGTTCTCTGGATCTTCCCTAGAAAAGTCAA
TATAATCAGCTATTGGATTTTGGAAATTATTCAGTACAGGGATTGGCAAAATTTCTCTGTAAAGAGGCAG
ATAGTATATCTTTTTGGGTTTGTAGGTCATATGGTCTCTGTTGCAACAATTCAACTCTGCCATTGTAGTG
TGAAAGTGCTATAGATTATATACAAATGAATGACTATGACTCTGTTCCAACAAACCTTTATTTATAAACA
CTAAAATGTTAATTTCATATAATTTTTATGTGTAATAAAATATTCGTTTTTCTTTCTATAAATTTTTATG
TTTTAATTTTTTATATATTTTTTATTTCAATAGGTTTTTGGGGAATAAGTCCTTTAGTGGTGATTTCTGA
GATTTTGGTGCACCCATCACCCGAACAGTGTACACTGTACCCAGTGTGTAGTCCTTTATCCCTCAGCCCT
CTCCCACTCTTTTCCCTGAGTCCCCAAAGTCCATTAGTCCCTTGTATCATTCTTAACGCCTTTGCGTCCT
CATAGCTTAGCTCCCACTTCTGAGTGAGAACATACAATGTTTGGTTTTTCATTCCTGAGTTACTTCACTT
ATAGTAGTGGTTTCCAATTCCATCCAGGCTGCTGCAAATGCCATTATTTTGTTCCTTTTTATGGCTGAGT
AGTATTCCATGGTGTGTATATATATATGTATATATATATACACATATATATGTATATATATACACATATA
TATGTATATATATATACATATATATGTATATATATATATACATATATATGTATATATATATATACATATA
TATGTATATATATACACACACACACACACACACACACACAGACACATTACAATTTCTTTATCCACTCATT
GATTGATGGGCATTTGGGCTGGTTCCATATTTTTGCAATTGCAAATTGTGCTGCTTTTTGTATAATGACT
TCTTTTCCTCTGGATAGATACCCAGTAGTGGGATTACTGGATTAAATCATAGTTCTACTTTTAGTTCCTT
AAGGAATCTCCACACTGTTTTCCATAGTCATACTAGTTTACATTCCCACAAGCAGTGTAAAAGTGTTCCC
CTTTCACCACATCCATGCCAACATGGGTTATTTTTTTATTTTTTGATTAAGGCCATTCTTACAAGAGTAA
GGTGGTATTGTGTTTTGATTTGCGTTTCCCTGATAATTAGTGATGTTGAGCATTTTTTCATATGTTTGTT
GGCCATTTGTATATCCTTTTCTGAGAATTGTCTTTTTATGTCCTTAGCCCACTTTTTGATGGGATTTTTT
TTTCAGCTGATTTGTTTGAGTTCCTTGTAGATTCTGGATATTAGTCCTTTGTTGGATATATAATTTACAA
ATATTTTCTCCCAATCTGTGGGCTGTTTACTCTGCTGATTATTTCTTTTGCTGTGCAGAAGATATTACTT
TTTAAAACTATTTTTGTTTTAAAAAAACACTTAAAATATAAAAGCCATCTTTAGTTCAAGGGCTGTAAAA
AACCAGCAGTGGGCCATATTTGACCCACAAAACTCAGTTTGCCATTTCTGATTTAGTAGGTTTATTCTCT
GAGCATTTTGTTCCCCTTTTCCATAGTTTGCCAAAGCAGTGTTGTCATCTCTATTGACAGCAGTATATCA
GAATCATCTCCTGGGGCCCTTGTGAGGGTGTTAAATATTGAGCGTTCCAATATTGACGCATTATCCCTCA
TCCAGGCTTATGTTCTACCCCCTACCACAATCCATCACCTTCAGAATTCATGCCTAGGCATCTTCTCCCA
GTCCCTGCCAGTAGATGTTAGCCAGGTCCTGTAGTATATAACCTTTCTATTCTCTTAGCAGACCCAGCAC
TTCCTCCATTAGCATGGGCTGAGATTTTATCCTAATTACGGGCCTGATGGACAGTAGGGGAGGCAGAGGC
AGGGCCCAGCAGGGATTCTTTTCCATCAAGGGGAAGTGGGCCACTTCTGCAGCTCCAGATGGTATAAGAG
AAGCAGGTGGTTCCTGGCTCTCAAATGCATCTTTCCAGAGATCCTCATTCCAAGTTTCAGGAGACTCCTC
CTCTACTATCAAGATGCTAGCTTTGGCATAGAAAATTTACCTAGGCTTAGAATCAGCCTTCTTTAAAGTC
CTGTCCCTCTTACAATTAGCTTATGTACCTGGTCTTCAGCTGTGGATAGACGAGTGTCTTTTAAATGCTG
CCAAGGAGGAGCTTTAACTCTCACACTTTGAGTTGCTGATAGATCTGAGGCTGTCATTTTCTCACTTCAG
TCCATCGGTGCAATTTAGCAAAAGTCAATTTTGAGTCCTAATATTAACTATTACCCTATACTGTTGACCC
AATTCCAGAGTTCTAACACTAACTATTTACCCTATACACCTCAAATGTTAGAGTCAGTGCACCAGCTCAT
AGTTTCCATCCATCTGTGTCCCATCTCATTTCACCACCAGTCATGGGGTTTGTGTTGCCATCTAGCAGGT
GAATGATCCCATTCCACAATCCTGTTCTTACAGGCTGCCTTCTAGGACTATTCCCAGCAGCAACTGTTTT
AGATCAGGTCCCCGGAAATAGAGCCTGACATGCAAATTTTGGTGAGAGTGACTTATTGGGACAGCTCTCA
GATGAAAAGTAGTGAAGGAAGCAGTATAGGGAGGGCTAAGGGAAGAAAGCTCAGCATGGATATGGTCTCA
GCTGGAGACTTGGCTGAAGCAAGAATTGTACAGAGTCGGTTGAACCTTTAGGCAGGGAGCTGGCATTTTG
GAAATCCACCTAGGTCAGTCATTACTTCTGGCTGCTCACCAGCGAGGGCCCAAGAGCAATTCTCCAGAGA
AGGGGCTGCTGTGAGCTCACAGCGTACACTCCCAGCATCTGGAAAATGGGAGTGCTGGTCAGGTAGAGAG
ATCTGAGCAGGAACTGTACATTAGTTATGGGTCTCCGGAGGGACAGAACCAATAGGAGATATAGATGGAT
GGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGTTGGATGGATGGATGGGTGGGTGGATGG
ATGGATGGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATGAGGAGGGATTTGTTAGGGG
AATTTGTTCAGGTGATTGTAAAGGCTGAGAAGTCTCACCACAGGCTGTCTGCAAGCTGGAGACCTTGGGA
TGCTGGTAGCATGGCTCAGTTCAAGTCCAACAGCCTCAGAACCACTGAGGCTGTTGGTGTAATTCTCAGT
CCAAGGCTAAGGGCCTGAAAACCCAGGGTCAGGAGCACTGGTTTAAGTCCTGGAGTCCGAAAGCCAGGGA
GCCTGGTGTCCTGATGTCCAAGGACAGGATGAGAAGAGTGTGTCCCAACTCCAAAGAGAGAAAGTACAAT
TTTGCCTCTCTTCTGTTTTGGGAAAGGCAGGCCTCCAGGTGAGTGGATGGTGCTTGGCTACATTTAGAGT
GTATCTTACCTACTCACTTCACTCAGACTGACATGCCAATCTCCTTTGGAAACACCCTCACAGACACACC
CAAAATGGGCTTTACTAGCTCTCTCAGCTCCCTTAATCCAGTTAAGATGATACCTAAAATTAGCTATGAC
AGGCACAACAGCATTCACTACAGACCTTGAGAGCCCATAGACTGTGTTATTTAGGAGCATGTTCTTTGGA
ATCAGACAGTCCTAGGTTTGGGTCCCAACTCAACCACTTGAGTAGCTGTACCACCTAACTTTGATGAACC
TCAGTTTTCTCATCTGTAAAATGCCGATAATTATGGCATTGCCTTCATAAGGTCATGAGAAAACTTCAGT
CAAATAATAATTAATGTAAGGCACTTAGCATTTTTCCTAGCATGTAAGCTGGAAAGGTGAGTGGGACCAT
CACAAGGGATGTTTTTGGGATCATCACAAGGGATGTTTTGGGGATCATCACAGTTTCTTATGAGGAATGT
AGTGAAATTATGGATTTTCTTCTTGGGCAAAATTTTCTATACAATTTACAAATCCCCTGAAATCCAGCTG
TGCATCTCAGGTTAAGCACCCTCCTATATACAGTGGAGCCATTGAAGAGTTTTAGGCAGAAATATGGACT
GACACAACTTTTGTTTTTGAAAATCACTCTGCTGGCGACCATGTGGAGTTGGACTAGAAGTAAGAGGGAG
TCCAGAGACAGTGAGGATGAAGCCCAGGTGTGAGAGAAGACATGGATATAGAGATGGAAAAGAGGGAGTA
GATTTCAGAACTGCCTAGGATTAAAATTGGATGAAGTTTTACAGATAAATTGAGTTGAACATTAGCCTCC
AGATTTCTGCTCAGCTGGTGCCATAAACCAGGGCAGTGAATATAGGGGCAGGAGTGGTTTGTTGGGGCAG
GAATGTGATGGTGTCGTTTGAGACAATTTGAGTCTGAGCTTGCCGTGGGTCATCAGGTGATGATGCCCAG
TGGACAGGTGGACACCTGCATCTGGAGCTCAGGGCAGAAGCCTGGGCTAGTTTAGATAGAGATTTGGGCA
TCTTCAGAGGACAGATGGTGGTTGTAGATGTAAGAAAGTAGATGCTCATGAAATCACTCAGAGAGCATGT
TTAGCGTGAGAGAAAGCAGAGAGCAGAACCCTGGGGAACCCCACGGTTTGGGGAGCTGATGTGCAAAGAG
AAAAGGGGCAGGCCTGGCTGAAGACGAAGGTGGGGGTTCAAAGGAGGAGAAGAAAATCAGGAGAGAGTGA
TGCCAAAGGATCCAGAGAAAGAGAACATTTCAGAAAGTAAGAGGTCGACAGAGTCAAGTGCAGTAAACAG
TACAAGAAAATAGAGAATGGAAAGCTGCCTCACTAAGCTTAGTGAACAGGAAGTAACAAGGTGTGTGGCA
CGTGGTATATGTAGTAAGTGCAGTTTCCATGGACTAGTTAGCATTTAAATCTAGCTGTAACGCGGTTGAG
AAATTAAGGGCTAAGGAATTGGTGTTGGTAAGAACATAAGTTTGCTGGTGTGCATGTGTGTAAGAAAGGA
AGAGAGAGATGTCATATTGGGGATTAACTGTTGAATAACATCCCCACATACTCACTTTGTAGTTTGTTTG
TTTTTAGAAGAAAGCCCTCAGAATCCATTCTGTGGAAGGTGACCTCAGGAGAAAATCAGCTGGACAGGAG
GAATGGAGCCCCAGTGCTCCCTCACCCCCAGGAAGCTGTGTCCAGGCAGAAGCTGCACCTGCTGGGCTCT
GTGGAGAGCAGCGGGGAGAGGACTGTGCCGAGCTGCATGACTACTTCAATGTCCTGAGTTACAGAAGCCT
GGGTAACTGCAGCTTCTTCACAGAGACTGGTTAGCAACCAGAGGCATCTTCTGGAAGATACACTTTTGTC
TTTGCTATTATAGATGAATATATAAGCAGCTGTACTCTCCATCAGTGCTGCGTGTGTGTGTGTGTGTGTA
TGTGTGTGTGTGTTCAGTTGAGTGAATAAATGTCATCCTCTTCTCCATCTTCATTTCCTTGGCCTTTTCG
TTCTATTCCATTTTGCATTATGGCAGGCCTAGGGTGAGTAACGTGGATCTTGATCATAAATGCAAAATTA
AAAAATATCTTGACCTGGTTTTAAATCTGGCAGTTTGAGCAGATCCTATGTCTCTGAGAGACACATTCCT
CATAATGGCCAGCATTTTGGGCTACAAGGTTTTGTGGTTGATGATGAGGATGGCATGACTGCAGAGCCAT
CCTCATCTCATTTTTTCACGTCATTTTCAGTAACTTTCACTCATTCAAAGGCAGGTTATAAGTAAGTCCT
GGTAGCAGCCTCTATGGGGAGATTTGAGAGTGACTAAATCTTGGTATCTGCCCTCAAGAACTTACAGTTA
AATGGGGAGACAATGTTGTCATGAAAAGGTATTATAGTAAGGAGAGAAGGAGACATACACAGGCCTTCAG
GAAGAGACGACAGTTTGGGGTGAGGTAGTTGGCATAGGCTTATCTGTGATGAAGTGGCCTGGGAGCACCA
AGGGGATGTTGAGGCTAGTCTGGGAGGAGCAGGAGTTTTGTCTAGGGAACTTGTAGGAAATTCTTGGAGC
TGAAAGTCCCACAAAGAAGGCCCTGGCACCAAGGGAGTCAGCAAACTTCAGATTTTATTCTCTGGGCAGG
CATTTCAAGTTTCCTTTTGCTGTGACATACTCATCCATTAGACAGCCTGATACAGGCCTGTAGCCTCTTC
CGGCCGTGTGTGCTGGGGAAGCCCCAGGAAACGCACATGCCCACACAGGGAGCCAAGTCGTAGCATTTGG
GCCTTGATCTACCTTTTCTGCATCAATACACTCTTGAGCCTTTGAAAAAAGAACGTTTCCCACTAAAAAG
AAAATGTGGATTTTTAAAATAGGGACTCTTCCTAGGGGAAAAAGGGGGGCTGGGAGTGATAGAGGGTTTA
AAAAATAAACACCTTCAAACTAACTTCTTCGAACCCTTTTATTCACTCCCTGACGACTTTGTGCTGGGGT
TGGGGTAACTGAACCGCTTATTTCTGTTTAATTGCATTCAGGCTGGATCTTAGAAGACTTTTATCCTTCC
ACCATCTCTCTCAGAGGAATGAGCGGGGAGGTTGGATTTACTGGTGACTGATTTTCTTTCATGGGCCAAG
GAACTGAAAGAGAATGTGAAGCAAGGTTGTGTCTTGCGCATGGTTAAAAATAAAGCATTGTCCTGCTTCC
TAAGACTTAGACTGGGGTTGACAATTGTTTTAGCAACAAGACAATTCAACTATTTCTCCTAGGATTTTTA
TTATTATTATTTTTTCACTTTTCTACCAAATGGGTTACATAGGAAGAATGAACTGAAATCTGTCCAGAGC
TCCAAGTCCTTTGGAAGAAAGATTAGATGAACGTAAAAATGTTGTTGTTTGCTGTGGCAGTTTACAGCAT
TTTTCTTGCAAAATTAGTGCAAATCTGTTGGAAATAGAACACAATTCACAAATTGGAAGTGAACTAAAAT
GTAATGACGAAAAGGGAGTAGTGTTTTGATTTGGAGGAGGTGTATATTCGGCAGAGGTTGGACTGAGAGT
TGGGTGTTATTTAACATAATTATGGTAATTGGGAAACATTTATAAACACTATTGGGATGGTGATAAAATA
CAAAAGGGCCTATAGATGTTAGAAATGGGTCAGGTTACTGAAATGGGATTCAATTTGAAAAAAATTTTTT
TAAATAGAACTCACTGAACTAGATTCTCCTCTGAGAACCAGAGAAGACCATTTCATAGTTGGATTCCTGG
AGACATGCGCTATCCACCACGTAGCCACTTTCCACATGTGGCCATCAACCACTTAAGATGGGGTTAGTTT
AAATCAAGATGTGCTGTTATAATTGGTATAAGCATAAAATCACACTAGATTCTGGAGATTTAATATGAAT
AATAAGAATACTATTTCAGTAGTTTTGGTATATTGTGTGTCAAAAATGATAATATTTTGGATGTATTGGG
TGAAATAAAATATTAACATTA
|
| Protein Name |
TIGIT_HUMAN |
| Length |
244 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
11-SEP-2007 |
| Definition |
RecName: Full=T-cell immunoreceptor with Ig and ITIM domains; AltName: Full=V-set and immunoglobulin domain-containing protein 9; AltName: Full=V-set and transmembrane domain-containing protein 3; Flags: Precursor |
| Primary Accession |
Q495A1 |
| Accession Version |
Q495A1.1 |
| Other SeqIDs |
sp|Q495A1.1|TIGIT_HUMAN,gi|121943253 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Oct 23, 2007 this sequence version replaced gi:121943254, gi:74755576, gi:74709870, gi:74760001.; [FUNCTION] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.; [SUBUNIT] Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to NECTIN2 and NECTIN3. {ECO:0000269|PubMed:22421438}.; [INTERACTION] Q495A1; Q15762: CD226; NbExp=4; IntAct=EBI-4314807, EBI-4314442; Q495A1; P21145: MAL; NbExp=3; IntAct=EBI-4314807, EBI-3932027; Q495A1; Q92692: NECTIN2; NbExp=6; IntAct=EBI-4314807, EBI-718419; Q495A1; Q9NQS3: NECTIN3; NbExp=2; IntAct=EBI-4314807, EBI-2826725; Q495A1; Q96NY8: NECTIN4; NbExp=2; IntAct=EBI-4314807, EBI-4314784; Q495A1; Q9Y342: PLLP; NbExp=3; IntAct=EBI-4314807, EBI-3919291; Q495A1; P15151: PVR; NbExp=2; IntAct=EBI-4314807, EBI-3919694; Q495A1; Q495A1: TIGIT; NbExp=2; IntAct=EBI-4314807, EBI-4314807.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q495A1-1; Sequence=Displayed; Name=2; IsoId=Q495A1-2; Sequence=VSP_027634, VSP_027635.; [TISSUE SPECIFICITY] Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). {ECO:0000269|PubMed:19011627}.; [DOMAIN] Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.; [SEQUENCE CAUTION] Sequence=CAI46183.1; Type=Erroneous initiation; Evidence={ECO:0000305}. |
| Source Db |
UniProtKB: locus TIGIT_HUMAN, accession Q495A1;; class: standard.; extra accessions:Q495A3,Q5JPD8,Q6MZS2,Q8N877; created: Sep 11, 2007.; sequence updated: Sep 13, 2005.; annotation updated: Oct 12, 2022.; xrefs: AK097192.1, BAC04973.1, AL833175.1, CAI46183.1, BX640915.1, CAE45956.1, BC101288.1, AAI01289.1, BC101289.1, AAI01290.1, BC101290.1, AAI01291.1, BC101291.1, AAI01292.1, NP_776160.2, 3Q0H_A, 3Q0H_B, 3RQ3_A, 3RQ3_B, 3UCR_A, 3UCR_B, 3UCR_C, 3UCR_D, 3UDW_A, 3UDW_B, 5V52_A, 5V52_B, 7VYT_A, 7VYT_T; xrefs (non-sequence databases): CCDS:CCDS2980.1, PDBsum:3Q0H, PDBsum:3RQ3, PDBsum:3UCR, PDBsum:3UDW, PDBsum:5V52, PDBsum:7VYT, AlphaFoldDB:Q495A1, SMR:Q495A1, BioGRID:128399, IntAct:Q495A1, STRING:9606.ENSP00000419085, ChEMBL:CHEMBL4630878, GlyGen:Q495A1, iPTMnet:Q495A1, PhosphoSitePlus:Q495A1, BioMuta:TIGIT, DMDM:121943253, jPOST:Q495A1, MassIVE:Q495A1, PaxDb:Q495A1, PeptideAtlas:Q495A1, PRIDE:Q495A1, ProteomicsDB:61948, ABCD:Q495A1, Antibodypedia:53759, DNASU:201633, Ensembl:ENST00000383671.8, Ensembl:ENSP00000373167.3, Ensembl:ENSG00000181847.12, Ensembl:ENST00000486257.5, Ensembl:ENSP00000419085.1, GeneID:201633, KEGG:hsa:201633, MANE-Select:ENST00000383671.8, UCSC:uc003ebg.3, CTD:201633, DisGeNET:201633, GeneCards:TIGIT, HGNC:26838, HPA:ENSG00000181847, MIM:612859, neXtProt:NX_Q495A1, OpenTargets:ENSG00000181847, PharmGKB:PA164726482, VEuPathDB:HostDB:ENSG00000181847, eggNOG:ENOG502SQW2, GeneTree:ENSGT00390000012671, HOGENOM:CLU_073090_0_0_1, InParanoid:Q495A1, OMA:EVTQVNW, OrthoDB:1484731at2759, PhylomeDB:Q495A1, TreeFam:TF338423, PathwayCommons:Q495A1, SignaLink:Q495A1, SIGNOR:Q495A1, BioGRID-ORCS:201633, ChiTaRS:TIGIT, EvolutionaryTrace:Q495A1, GenomeRNAi:201633, Pharos:Q495A1, PRO:PR:Q495A1, Proteomes:UP000005640, RNAct:Q495A1, Bgee:ENSG00000181847, ExpressionAtlas:Q495A1, Genevisible:Q495A1, GO:0009986, GO:0016021, GO:0005886, GO:0042802, GO:0005102, GO:0032695, GO:0050868, GO:0032733, Gene3D:2.60.40.10, InterPro:IPR007110, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003599, InterPro:IPR013106, InterPro:IPR042948, PANTHER:PTHR47734, Pfam:PF07686, SMART:SM00409, SUPFAM:SSF48726, PROSITE:PS50835 |
| Sequence |
mrwcllliwaqglrqaplasgmmtgtiettgnisaekggsiilqchlssttaqvtqvnweqqdqllaicnadlgwhispsfkdrvapgpglgltlqsltvndtgeyfciyhtypdgtytgriflevlessvaehgarfqipllgamaatlvvictavivvvaltrkkkalrihsvegdlrrksagqeewspsapsppgscvqaeaapaglcgeqrgedcaelhdyfnvlsyrslgncsfftetg |
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