|
|
| Record Information |
| Record ID |
59 |
| Pubmed ID |
29587677 |
| SNP |
|
| Gene ID |
54742 |
| Protein ID |
P08195 |
| Vaccine Adverse Events |
decreased appetite , myalgia , injection site erythema/induration , aspartate aminotransferase increase , blood alkaline phosphatase increase , and diarrhea , lung infection and blood alkaline phosphatase increase, a transient rise in aspartate transaminase , anaemia |
| Vaccine |
OTSGC-A27 combined peptide cancer vaccine |
| Gene Name |
LY6K |
| Official Symbol |
lymphocyte antigen 6 family member K [Homo sapiens (human)] |
| Aliases |
CT97, HSJ001348, URLC10, ly-6K |
| Other Designations |
lymphocyte antigen 6K; cancer/testis antigen 97; lymphocyte antigen 6 complex, locus K; up-regulated in lung cancer 10 |
| Chromosome |
8 |
| Location |
8q24.3 |
| Annotation |
Chromosome 8 NC_000008.11 (142700111..142705127) |
| MIM |
615093 |
| DNA Sequence |
>NC_000008.11:142700111-142705127 Homo sapiens chromosome 8, GRCh38.p14 Primary Assembly
GAGTTATCAGAGGTGAGCCCGTGCTCTTCAGCGGAGAAGATCCCCTACCTGGCCGCCGGCCACTTTCTGT
GGGCCGTGGGGTCCTCAAGGAGACGGCCCTTGGGCTCAGGGGCTGCGTTTCCACACGCGCCTTTCCCAGG
GCTCCCGCGCCCGTTCCTGCCTGGCCGCCGGCCGCTCCAACAGCAGCACAAGGCGGGACTCAGAACCGGC
GTTCAGGGCCGCCAGCGGCCGCGAGGCCCTGAGATGAGGCTCCAAAGACCCCGACAGGCCCCGGCGGGTG
GGAGGCGCGCGCCCCGGGGCGGGCGGGGCTCCCCCTACCGGCCAGACCCGGGGAGAGGCGCGCGGAGGCT
GCGAAGGTTCCAGAAGGGCGGGGAGGGGGCGCCGCGCGCTGACCCTCCCTGGGCACCGCTGGGGACGATG
GCGCTGCTCGCCTTGCTGCTGGTCGTGGCCCTACCGCGGGTGTGGACAGACGCCAACCTGACTGCGAGAC
AACGAGATCCAGAGGACTCCCAGCGAACGGGTGAGCCTGGCTCGCCCTCCACAGCCACGGGCCGAGAGGA
CAGGGCCGGGCGGCGTCTGCCTGGCACCGCGTGGCCACCGCCCCGACCAGGCCGTGAGAACGGAGCGTTC
AGGCGGCCCGTGGCGCCTGGAAGCCTCTGGGGAGCCTCGCCTCGTGCGGCTTCCACCAGGGCGGCGGGGC
AGCCTGAGCCCGGCCCTTCCCCAGCCCTTGCCCCGCTCCGGCCGCGCTTCCCCGGGAGCCCTCAGGCTGC
AGGCTCCCGCCGGCCTGGCCTCCGGGGGCTTCACGGGCTGAGAACCGTTCAAGCTGCGGGAGGAGGGCCG
GCTCCTCCTGCAGAGCTAGGCCAGGCCCAACCCAGACCCAAGGGAGAACTCCTTTGAGGGAGTCGGGGGG
CAGGACCTGGGAGGTGGGTGGACCTGGGAGGTGGGCGGGAGGGCACGTGGGAGCAGACCCAAGCCCCAGG
GTCACTTCCACAGCCGTCGGCCGGGAGATGCCAGGGCCCGTGGGTGCCGCGTGGCCGACCTGGGGTCAGG
GTGCTGCGGCCGAGTGGGGGTGCGCTGTGCGCTCATGTTGTGTGCTTGGATGTGGGAGGACGGGGGAGCC
CCCAGGAGAGAAGAAAAATCACTCAGAATGTAAAGAAGTCCGGGGGCTGGGCAATTTATAAAGAAGAGAG
GTGGAATTGGCTCACAGTTCCACAGGCTGTCCAGGAAGCGTGGTGCTGGCTTCTGGGGAGGCCTCAGGGC
ACTTACAATCATGGGGGAAGGCGAAGGGGAAGCGGGCAGCTCTTACGTGGCCGGAGACCCCTCCTGCTTT
CTCCCCATGCGGCTCACTCGAGTCATGTGGCCCCAGCCACTGCTCAGGGGGAGAAGGATGGGGACCCGCC
GAGTTTGTGCTGGTCGGATGCCGGCTGTGTTCATCAGATAGGCACGGAGAACTGGAACATTCTGCTTTCT
TTTTTATTCCTCCTTTCAGACGAGGGTGACAATAGAGTGTGGTGTCATGTTTGTGAGAGAGAAAACACTT
TCGAGTGCCAGAACCCAAGGAGGTGCAAATGGACAGAGCCATACTGCGTTATAGCGGCCGTGAGTGAGTA
TCTTCGCTCTTGTTGGGGACCCAAAGGCAGGTGAACAGAGGGCTTTCAGGAATCAGGGCTGTCTAGTTTT
CCTCAATGGGGAATAACTAATAGAAAGTAGCCTTTTTTTTTTTTTATTTTCTGAGACGGAGTCAGGCTGG
AGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCGCCTTCCGGGTTCAAGCGATTCTCCTGCCTCAGCC
TCCAGAGTAGCTGGTATTATGGATGCGCGCCACCACACTGGCTAATTTTTTATTTTTAGTAGAGGTGGGG
TTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGACCCACCCGCCCTCGGCCCCCCAA
AGTGCTGGGATTACAAGCGTAAGCCACCGCGCCCTGCCTTTTTTTCCCTTTAAAATGTGAAGAGCAAAGT
CCTCAGAGGCCAGAGAGAGGTGTAGGAACTGTGCTAGTGTAAGGCAGTGCCTGCTACAGTGGGTCCAGAT
GAAATACTGGGAGGTAGGAAGAAAATCTGGATTTCATATCATCCATTTTTAAATGAAAAATTAAGCTTTA
ATAGTGTTAAATGCGCCACAGAGAACAGTGTCTATGTCACTCTTACAAGAGATGCACAAAACCAAGGTGT
ACAGCCTTCAAGTGTGTTCTCAAAGGAGGGTGCATGCCTTAAAAATTGTGGAGACCACTGCTCTGTCATC
TGTGATTCCCCTGAAAACCTCTGGGTACATGAAGCCCTCCCCAAGGGGAATCTGGACACCCAGCACATTC
TGCCCACAGGGAGATCTTCAGGGCTCGTGAATTCTGATTCCGCCCAGCAGTCACTCTCCAGCCCTTCGGT
ATCCACGAAGTTGGTGGGGTGCTGAGGTGATGCTTCAGACTCAGTGTGGCCCACATCGACTTTATAACTT
AATATGGCAAAATGATTTGTACAGTGATGTATAAGATGAAGTGTGGTCATGAGACAAGACCCCCAGCTCA
GAGTCGAGCCAGGCCCACCAAGAGGCCAGCTCCACACCCTGGGTGATGGCCAGAATGGCTGGGAGTCATG
TGTCTGTCTGTGGTCACAAAGGCCTGAGCCAACCCTGTGTTTGAGAAGTTGAGACCTGTTTGTTCCCAAA
CAGCAACCCCTAGACCCGCATTCCCAGTGCATATGGACAGGCCATACCACGCAGAAGCCAGCCCTTCCCT
GAAGCAGCATTCAACACACAGGCCTGGCCCTCGTCCTCCCGACTCCCCCTTGGTGCCCCAGTTGACTGTG
CACCTTTGAGCAGGGCCGCCAGGGGTGAGGCTTTGACCCAGACAGAAGGGCCTCGGTGTCAGGCATTGGA
ATTGCGTGATTGCCTTCTCTCGGTCTTTATTTCCTATTAGAAATATTTCCACGTTTTTTCATGGTTGCGA
AGCAGTGCTCCGCTGGTTGTGCAGCGATGGAGAGACCCAAGCCAGAGGAGAAGCGGTTTCTCCTGGAAGA
GCCCATGCCCTTCTTTTACCTCAAGTGTTGTAAAATTCGCTACTGCAATTTAGAGGGGCCACCTATCAAC
TCATCAGTGTTCAAAGAATATGCTGGGAGCATGGGTGAGAGCTGTGGTGGGCTGTGGCTGGCCATCCTCC
TGCTGCTGGCCTCCATTGCAGCCGGCCTCAGCCTGTCTTGAGCCACGGGACTGCCACAGACTGAGCCTTC
CGGAGCATGGACTCGCTCCAGACCGTTGTCACCTGTTGCATTAAACTTGTTTTCTGTTGATTACCTCTTG
GTTTGACTTCCCAGGGTCTTGGGATGGGAGAGTGGGGATCAGGTGCAGTTGGCTCTTAACCCTCAAGGGT
TCTTTAACTCACATTCAGAGGAAGTCCAGATCTCCTGAGTAGTGATTTTGGTGACAAGTTTTTCTCTTTG
AAATCAAACCTTGTAACTCATTTATTGCTGATGGCCACTCTTTTCCTTGACTCCCCTCTGCCTCTGAGGG
CTTCAGTATTGATGGGGAGGGAGGCCTAAGTACCACTCATGGAGAGTATGTGCTGAGATGCTTCCGACCT
TTCAGGTGACGCAGGAACACTGGGGGAGTCTGAATGATTGGGGTGAAGACATCCCTGGAGTGAAGGACTC
CTCAGCATGGGGGGCAGTGGGGCACACGTTAGGGCTGCCCCCATTCCAGTGGTGGAGGCGCTGTGGATGG
CTGCTTTTCCTCAACCTTTCCTACCAGATTCCAGGAGGCAGAAGATAACTAATTGTGTTGAAGAAACTTA
GACTTCACCCACCAGCTGGCACAGGTGCACAGATTCATAAATTCCCACACGTGTGTGTTCAACATCTGAA
ACTTAGGCCAAGTAGAGAGCATCAGGGTAAATGGCGTTCATTTCTCTGTTAAGATGCAGCCATCCATGGG
GAGCTGAGAAATCAGACTCAAAGTTCCACCAAAAACAAATACAAGGGGACTTCAAAAGTTCACGAAAAAA
TTGAATTAAAAGATAAAAATTAAAAAATGTTTTATTTCTCAGCATGAGCTCCATCAAGGTCGAGACGCTT
CTGCAAGTAATGGTACCAGCCATTCAGTTCATCCCTAAAGAATTGGGCACCCTGGGAATTTAACCATGCC
ACTTCAGTCTTTGTGACGTTATTAACTGAAGAAAAGTGGGTGCCCTTTAAAGATTTTTTAAAATTATAAA
ACAGAAGTAACCAAATCAGGCCTGGAAGGTGTATGCCTAGTGATTTCCCATTGAAACTCTCACAAAACTG
GCCTTGTTTGATGAGAGGAATGAGCAGGAGCATTGTCATGGTGGAGAAGGGCTCTCTGGTGAAGCTTTCC
GGGGTGACGATTTCCTGGGTGTTTTCCTGCTAAATCGTTGGCTGACTTTCTCTATACACTCTCATAATAA
GATGTTACTGTTCTTTGGCCCTCCAGAAAGTCAATAAGCAAGATGCCTTGAGCATTCACAAAACGGTTGC
CACGACCTTTGCCCTTGACATGTCTGCTTTTACTCTGATGGGACCACGCCCACCTCTAGGTAGTCATTGC
TTTGCTTGTGCTTTGCCTTCAGGAGTGTACTGGTTAAGCCACATTTCATCTCCGGCTATAATTATATGAA
GAAATGCTTCAGGATCTTGATTCCACTTGTTTAAAATGGCCATAGAACGCTTTTCTCTTATCTGCAGCTG
AGCTGGGAGAAAGTTTTGGCACCCACCGAGTGGACAGTTTACTCAACTTTAATTTCAGTCAGAATTGTGT
AAGCTGAACACCTTGGGATACCTACAGCGTTGGCTATTGTTTCTGCTGCTATTAATCAGTCCTCTTAAAT
TAGGGCACAAACAAGATGAATTGTTTCCTCACAGACTGATGTGGCTGGCCTGCTGCTGTGGACTTCCTCT
CCAACATCATCTCTTCTCTTCTTCCAATGAGTTATCCACTTACTTAA
|
| Protein Name |
4F2_HUMAN |
| Length |
630 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-AUG-1988 |
| Definition |
RecName: Full=4F2 cell-surface antigen heavy chain; Short=4F2hc; AltName: Full=4F2 heavy chain antigen; AltName: Full=Lymphocyte activation antigen 4F2 large subunit; AltName: Full=Solute carrier family 3 member 2; AltName: CD_antigen=CD98 |
| Primary Accession |
P08195 |
| Accession Version |
P08195.3 |
| Other SeqIDs |
sp|P08195.3|4F2_HUMAN,gi|1812588799 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Feb 25, 2020 this sequence version replaced gi:1787078151.; [FUNCTION] Component of several heterodimeric complexes involved in amino acid transport (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:30341327). The precise substrate specificity depends on the other subunit in the heterodimer (PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:30867591, PubMed:10903140). The complexes function as amino acid exchangers (PubMed:11557028, PubMed:10903140, PubMed:12117417, PubMed:12225859, PubMed:30867591). The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:11557028, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140). The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine (PubMed:25998567, PubMed:30341327). When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals (PubMed:12716892). Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity (PubMed:9751058, PubMed:11311135, PubMed:30867591). Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine (PubMed:14603368). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). {ECO:0000250|UniProtKB:P10852, ECO:0000250|UniProtKB:Q794F9, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30341327, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; [FUNCTION] (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; [BIOPHYSICOCHEMICAL PROPERTIES] Kinetic parameters: KM=295 uM for glutamine (in the presence of NaCl) {ECO:0000269|PubMed:10903140}; KM=236 uM for leucine (in the presence of NaCl) {ECO:0000269|PubMed:10903140}; KM=120 uM for arginine (in the presence of NaCl) {ECO:0000269|PubMed:10903140}; KM=138 uM for arginine (in the absence of NaCl) {ECO:0000269|PubMed:10903140}.; [SUBUNIT] Disulfide-linked heterodimer with a non-glycosylated light chain (SLC7A5/LAT1, SLC7A6, SLCA7A7, SLC7A8/LAT2, SLC7A10 or SLCA7A11) (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:10903140,PubMed:11311135, PubMed:30867591). Interacts with TLCD3A/CT120 (PubMed:12270127). Interacts with ICAM1 (PubMed:12716892). Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1 (PubMed:11696247). Interacts with LAPTM4B; recruits SLC3A2 and SLC7A5/LAT1 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567). {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11696247, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12270127, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:17724034, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; [SUBUNIT] (Microbial infection) Interacts with hepatitis C virus/HCV envelope glycoprotein E2; the interaction may facilitate viral entry into host cell. {ECO:0000269|PubMed:30341327}.; [INTERACTION] P08195; O15354: GPR37; NbExp=3; IntAct=EBI-702356, EBI-15639515; P08195; Q01650: SLC7A5; NbExp=2; IntAct=EBI-702356, EBI-6138761; P08195; O52302: sepZ; Xeno; NbExp=5; IntAct=EBI-702356, EBI-14022357; P08195-1; Q01650: SLC7A5; NbExp=3; IntAct=EBI-11614088, EBI-6138761; P08195-4; Q9NX09: DDIT4; NbExp=3; IntAct=EBI-12832276, EBI-715104; P08195-4; Q15125: EBP; NbExp=3; IntAct=EBI-12832276, EBI-3915253; P08195-4; P21333-2: FLNA; NbExp=3; IntAct=EBI-12832276, EBI-9641086; P08195-4; P04792: HSPB1; NbExp=3; IntAct=EBI-12832276, EBI-352682; P08195-4; O60333-2: KIF1B; NbExp=3; IntAct=EBI-12832276, EBI-10975473; P08195-4; Q5T3J3: LRIF1; NbExp=3; IntAct=EBI-12832276, EBI-473196; P08195-4; P31153: MAT2A; NbExp=3; IntAct=EBI-12832276, EBI-1050743; P08195-4; Q9UPY5: SLC7A11; NbExp=3; IntAct=EBI-12832276, EBI-3843348; P08195-4; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-12832276, EBI-13292283; P08195-4; O76024: WFS1; NbExp=3; IntAct=EBI-12832276, EBI-720609; P08195-4; Q96BH6; NbExp=3; IntAct=EBI-12832276, EBI-25872486.; [SUBCELLULAR LOCATION] Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}. Lysosome membrane {ECO:0000269|PubMed:25998567}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:9751058, PubMed:11311135). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P08195-1; Sequence=Displayed; Name=2; IsoId=P08195-2; Sequence=VSP_037907; Name=3; IsoId=P08195-3; Sequence=VSP_037908; Name=4; IsoId=P08195-4; Sequence=VSP_037909.; [TISSUE SPECIFICITY] Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1. {ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:3265470, ECO:0000269|PubMed:3480538}.; [INDUCTION] Expression is induced in resting peripheral blood T-lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesis, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. Up-regulated in response to hydrogen peroxide (PubMed:30341327). {ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:30341327, ECO:0000269|PubMed:3265470, ECO:0000269|PubMed:3480538}.; [INDUCTION] (Microbial infection) Up-regulated upon hepatitis C virus/HCV infection via NS3-A4 viral protein complex; the up-regulation is mediated by oxidative stress (PubMed:30341327). Up-regulation of the complex formed by SLC3A2 and SLC7A5/LAT1 upon hepatitis C virus/HCV infection (PubMed:30341327). {ECO:0000269|PubMed:30341327}.; [PTM] Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions. {ECO:0000269|PubMed:19065266}.; [MASS SPECTROMETRY] Mass=57944.93; Method=MALDI; Evidence={ECO:0000269|PubMed:11840567}.; [MISCELLANEOUS] Arginine uptake is inhibited by increasing concentrations of leucine in the presence of Na(+).; [SIMILARITY] Belongs to the SLC3A transporter family. {ECO:0000305}. |
| Source Db |
UniProtKB: locus 4F2_HUMAN, accession P08195;; class: standard.; extra accessions:Q13543; created: Aug 1, 1988.; sequence updated: Sep 1, 2009.; annotation updated: Oct 12, 2022.; xrefs: J02939.1, AAA52497.1, J02769.1, AAA51540.1, J03569.1, AAA35536.1, M21904.1, AAA35489.1, M21898.1, M21899.1, M21900.1, M21901.1, M21902.1, M21903.1, AB018010.1, BAA84649.1, AP001160.4, BC001061.2, AAH01061.2, BC003000.1, AAH03000.2, BE794697.1, SAHU4F, NP_001012680.1, NP_001012682.1, NP_001013269.1, NP_002385.3, 2DH2_A, 2DH3_A, 2DH3_B, 6IRS_A, 6IRT_A, 6JMQ_B, 6JMR_B, 6S8V_B, 6S8V_D, 7B00_B, 7CCS_A, 7P9U_A, 7P9V_A; xrefs (non-sequence databases): CCDS:CCDS31589.1, CCDS:CCDS31590.1, CCDS:CCDS8039.2, PDBsum:2DH2, PDBsum:2DH3, PDBsum:6IRS, PDBsum:6IRT, PDBsum:6JMQ, PDBsum:6JMR, PDBsum:6S8V, PDBsum:7B00, PDBsum:7CCS, PDBsum:7P9U, PDBsum:7P9V, AlphaFoldDB:P08195, SMR:P08195, BioGRID:112411, CORUM:P08195, IntAct:P08195, MINT:P08195, STRING:9606.ENSP00000367123, GuidetoPHARMACOLOGY:890, CAZy:GH13, TCDB:2.A.3.8.18, TCDB:8.A.9.2.2, GlyConnect:984, GlyGen:P08195, iPTMnet:P08195, MetOSite:P08195, PhosphoSitePlus:P08195, SwissPalm:P08195, BioMuta:SLC3A2, DMDM:257051063, EPD:P08195, jPOST:P08195, MassIVE:P08195, MaxQB:P08195, PaxDb:P08195, PeptideAtlas:P08195, PRIDE:P08195, ProteomicsDB:52082, ProteomicsDB:52083, ProteomicsDB:52084, ProteomicsDB:52085, ABCD:P08195, Antibodypedia:15042, DNASU:6520, Ensembl:ENST00000338663.12, Ensembl:ENSP00000340815.7, Ensembl:ENSG00000168003.18, Ensembl:ENST00000377889.6, Ensembl:ENSP00000367121.2, Ensembl:ENST00000377890.6, Ensembl:ENSP00000367122.2, Ensembl:ENST00000538084.2, Ensembl:ENSP00000440001.2, Ensembl:ENST00000544377.2, Ensembl:ENSP00000442135.2, Ensembl:ENST00000680631.1, Ensembl:ENSP00000506006.1, Ensembl:ENST00000681657.1, Ensembl:ENSP00000505110.1, GeneID:6520, KEGG:hsa:6520, MANE-Select:ENST00000338663.12, UCSC:uc001nwd.4, CTD:6520, DisGeNET:6520, GeneCards:SLC3A2, HGNC:11026, HPA:ENSG00000168003, MIM:158070, neXtProt:NX_P08195, OpenTargets:ENSG00000168003, PharmGKB:PA35894, VEuPathDB:HostDB:ENSG00000168003, eggNOG:KOG0471, GeneTree:ENSGT00940000156646, HOGENOM:CLU_006462_9_0_1, InParanoid:P08195, OrthoDB:1384693at2759, PhylomeDB:P08195, BioCyc:MetaCyc:ENSG00000168003-MON, PathwayCommons:P08195, Reactome:R-HSA-210991, Reactome:R-HSA-352230, Reactome:R-HSA-5660862, Reactome:R-HSA-71240, SABIO-RK:P08195, SignaLink:P08195, BioGRID-ORCS:6520, ChiTaRS:SLC3A2, EvolutionaryTrace:P08195, GeneWiki:SLC3A2, GenomeRNAi:6520, Pharos:P08195, PRO:PR:P08195, Proteomes:UP000005640, RNAct:P08195, Bgee:ENSG00000168003, ExpressionAtlas:P08195, Genevisible:P08195, GO:1990184, GO:0070161, GO:0016324, GO:0044225, GO:0009925, GO:0016323, GO:0009986, GO:0070062, GO:0016021, GO:0005765, GO:0042470, GO:0016020, GO:0005654, GO:0005886, GO:0045202, GO:0015173, GO:0045296, GO:0005432, GO:0003725, GO:0015180, GO:0015190, GO:0015175, GO:0003723, GO:0006865, GO:0006816, GO:0005975, GO:1904273, GO:1903801, GO:0098713, GO:0015820, GO:0015823, GO:0043330, GO:0015827, GO:0046718, Gene3D:2.60.40.1180, InterPro:IPR006047, InterPro:IPR013780, InterPro:IPR017853, InterPro:IPR042280, InterPro:IPR031984, PANTHER:PTHR46673, Pfam:PF00128, Pfam:PF16028, SMART:SM00642, SUPFAM:SSF51445 |
| Sequence |
melqppeasiavvsiprqlpgshseagvqglsagddselgshcvaqtglellasgdplpsasqnaemietgsdcvtqaglqllassdppalasknaevtgtmsqdtevdmkevelnelepekqpmnaasgaamslagaeknglvkikvaedeaeaaaaakftglskeellkvagspgwvrtrwallllfwlgwlgmlagavviivraprcrelpaqkwwhtgalyrigdlqafqghgagnlaglkgrldylsslkvkglvlgpihknqkddvaqtdllqidpnfgskedfdsllqsakkksirvildltpnyrgenswfstqvdtvatkvkdalefwlqagvdgfqvrdienlkdassflaewqnitkgfsedrlliagtnssdlqqilsllesnkdllltssylsdsgstgehtkslvtqylnatgnrwcswslsqarlltsflpaqllrlyqlmlftlpgtpvfsygdeigldaaalpgqpmeapvmlwdessfpdipgavsanmtvkgqsedpgsllslfrrlsdqrskersllhgdfhafsagpglfsyirhwdqnerflvvlnfgdvglsaglqasdlpasaslpakadlllstqpgreegsplelerlklepheglllrfpyaa |
|
