|
|
| Record Information |
| Record ID |
56 |
| Pubmed ID |
29587677 |
| SNP |
|
| Gene ID |
2305 |
| Protein ID |
Q08050 |
| Vaccine Adverse Events |
decreased appetite , myalgia , injection site erythema/induration , aspartate aminotransferase increase , blood alkaline phosphatase increase , and diarrhea , lung infection and blood alkaline phosphatase increase, a transient rise in aspartate transaminase , anaemia |
| Vaccine |
OTSGC-A24 combined peptide cancer vaccine |
| Gene Name |
FOXM1 |
| Official Symbol |
forkhead box M1 [Homo sapiens (human)] |
| Aliases |
FKHL16A, FOXM1B, FOXM1C, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TRIDENT, FOXM1 |
| Other Designations |
forkhead box protein M1; Forkhead, drosophila, homolog-like 16; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; forkhead box M1-D; forkhead-related protein FKHL16; hepatocyte nuclear factor 3 forkhead homolog 11; transcription factor Trident; winged-helix factor from INS-1 cells |
| Chromosome |
12 |
| Location |
12p13.33 |
| Annotation |
Chromosome 12 NC_000012.12 (2857680..2877174, complement) |
| MIM |
602341 |
| DNA Sequence |
>NC_000012.12:2857680-2877174 Homo sapiens chromosome 12, GRCh38.p14 Primary Assembly
GCATGTCCACCTTCGCTTTTATTGAGTAGTTAGTGTTCTCAAGCTGGCTCACACCCATGCGGTCAGCTGG
GGCCTAGGGTGGCTCTTTGCAAAGCTGAGGGGCAAGCTAAGGAAGCCAGGCAGGTCAGGGGCCCTTTCGG
CCTTCTCAAGCCTCCACCTGAGTTCTCGTCAATGCCAGTCTCCCTGGTATGATTGGGGACATTATCAGAG
AAACATCTAATAGCGCACATCTGGGCACCCACACTCTGCTTCAGTTGCATCCATCCTCCCACCCCAAATT
CAACTCCTGACCCAATACAAAAGACTTTTTTAACCAGGATTTCTTCTTGCAGGAAAGCTGACTTGGAAAC
ACGGGGAGGTGGCAGGGAGGGGCAAAAAGGACTCTGGCAAGCAGATCCACTTGTCTGGGTCCCTGCAGTG
AAGAACCCAAGATCCAGGTACCTCAGCCTGGAAGAAACCGTGCACTGCAGGTCTTCCCTTCTATCAAAAC
TAAAAGCAAGGAACAGAAGTCAATTGAAACCCCAGGTCATCCTACCCACCTTCTGGCAGTCTCTGGATAA
TGATCTAAGGAAATAAGCTTACATTTATAATTAGAGGATAATTTGGAGAATTTATACTATTTACACGGAC
CACCCTGCAAAGATCAGGGAAGGTAAGAGACTGCTGGGCAGAGAATGGAAACAGGCTGGGGGGTTCCTAA
TCTCTTTTCACCATTGCCTTTGTTGTTCCCACCCTTCAGCTCCTGGCAGGGACAGCAGAGGAATCAGATA
CTCTTGGGGAACACAAGGTCCCAGCAGTGGCTAGGGTGTGACTGCTACTTTTGCATAATCAGGCAGCAGG
GAGCTATGAGGAGCAGAACAGTCCCTGCCTGCTGTCCTCACTCAGAGGCTTGGGGTGCACTGAGCCTTGG
AGTGCCCGGGATGGTGGACAGCTTGAGCACAGGGGCAAGGGCAGGGCTCTACTGTAGCTCAGGAATAAAC
TGGGACCAGTTGATGTTGTCAGGGCCCAGTGGGTCCTCGTCCAGGCCAGGAAAGCTGATGTCCAGCAGGA
TCTTGCTGAGGCTGTCATTCATTGTGTCCAGGACCAGGCCTTCTGTCAGAGAACGATTGGCTGCAAGGCC
AGAAACCTGTGGCTCCGGGGAGCCTGGCTTGGGGACGTCTATATCTGAGGGAGAAGAGTTGCCAAAGGGG
ACGGAGATGAGGTCTAAGGGTTCTGAACTGAGGAGCCTTTGCGGTGATTCAAGGGGGGGAGCACTTTGCA
AGGGAGTGGTGCTGAGATCCATCAGCCCCAGGGGGTCAGGCAAGGGGTCAGAGGCACCCTGGGAGGTTTG
TACTGGGCTGAAATCCAGTCCCCCTACTTTGGCTGGGGGCGTGAGCCTCCAGGATTCAGGGGTTCTGGGG
AGGACAGATTTGCTCGGGGTGGAGGAGATGGGCAGCGTTTCCTTAATGGGTGTCTTAAAAGGTCCTCCCA
CTTCCTGGGAGTAGCTGAGCTGGGAGGCAGGGTCAGAGGAGTCTGCTGGGAACGGGAGCTCTGCGGCCCA
GCGGGAAGTACTGGGCCCCTCTGAGAAGAGCAGCTCCGGCTCATCCACACAGGGAGGCAGTAGATGCTGT
TTTCTCCGAGACCGGCTCCTCTCCCTCCTCTCCCTGTGTTGAATCACAAGCATTTCCGAGACACACCGGG
TTGGGGACCTAAGCCCACTGTAGGACTTCTTGGGTCTTGGGGTGGGAGATTGGGACGAATCCTCCCAGGA
GTGAGATGATTCCTCTTTGAAAGATGGGGCCGGGGAGGGCCACTCTTCCAAGGGAGGGCTCTCCACTTTG
ATGGGTCTCGCTAAGTGTGGCATTTCCTCCCCAGGCTGGATTTCTTCCTCCTTGATAGTCTGAACTGGAA
GCAAAGGAGAAAACCCTTCTCCAAACAGGAGTTTCTCCTCTTTCCCTGGTCCTGCAGAAGAAAGAGGAGC
TATCCCCTCCTCAGCTAGCAGCACCTGAAAGGGAAACAGAGATAAGGTGAACCAACGGTCACCAGACAGG
ACGCACAAAAATATCACATACGGGTTCTGATCCTCTTTGTGTCGTTTTGAAGTCTTAAAATCTATTAAAT
ATGAGAATACGATGTATGTTGAAGTTGGTAGTTCAATTCTGGGGGTAAAAGATGCGGGTATGTAGTATGT
AGTGGCATAATTATAATAGCATTCATCCGAGAGGAAATAAAATTGCATGCTTGTCTTACACTGTATACAA
AGATTTAATGCATGAAAATAAGAACCTTAGGCTGCTCTGATGGTAGCGGGTAGTGACATTATTGTCACTA
AAGTTGGTACACAACCCCCAACTGCTAAATTTGACTGGCTTTAAAAAAAAAATGAAAACCTTAAAATCAT
ACAAATCCTGAAAGAGAATCTAGGAGACTACATATACAATCTGAGGGTGCGGGTGACCTTCTTAACCAAG
ACTGGAAACCCAGAAACTGTAAAAGAGAAGAGAGACATTTGACTACATAAAACTTTAAAATTTTACTGTG
GCAAGAGATACCATAAACAAAGTTAAGAAACAACAAACAATGCCTGTAATCCCAGCACTGCAAGACACTG
AGGCCAGTTTGAGACCAGCCTGAGCAACATAGTGAGATCCCATCTCTACAAAAAAATTTTTTTTAATTAG
CTGGATGTGGTGGCATGCACCTGTAGTTCCAGCTACAGGTGGGAGGCTGAGGTGGGAAGATCACTTGAGC
CTGGGAGGTCAAGGATGTAGTGAGCCTTCATTACACCACTGCACTCCAGACTAGGCAACATAGCAAGATC
CTGTCTCAGAAAAGAAAAGAAAGGAAAGTAAAGAGATAAACAATAGAAGTAGAAAAATATCTTCAGCATA
AAAGAAAGAAGATTATTTTAACAACAAAGAGCTCTCACAGGGGGCTGGGTGCGGTGGCTCACGCCTGTAA
TCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGTCAGAAGTTCGAGACCAGCCTGACCAACA
TGGTGAAACCTTGTCTCTACTAAAAATACAAAATTAGCCGGGCGTGGTGGCATGCACCTGTAATCCCAGC
TACTCGGGAGGCTGAGGCACGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCCAAGATCACACCACTGT
ACTTCAGCCTGGGTGACATAGCAAGACTCCATCTCAAAAAAAAAAAAAACTCTCACAGGCTGGGCGTGGT
GGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCATGAGGTCAGGAGTTCGTGAC
CAGCCTGGCCAAGATGGTGAAACCCTGTCTCTACTAAAAAATACAAAAATTAGCTGGGCGCAGTGGTGGG
CGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGTCTGCA
GTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAA
AAAGAGCTCTCACAAATTGATAACAAAACCTATATAAAAATGGGCAATGTTCATAAATAACCAATTCATA
GAGGACAATTCCAAGTCACCAAACATAATGACAAGGTGCTCAGACTTACTGATAAACAAAGAAAGATAAA
ATTAAACAAGCTGGTGATGGGTGTACCAAAATCTCGCAGATCGCCACTAAAGAACTTACTCATGTAACCA
AACACCACCTGTTCCCCAAAAACCTATGGAAATAAAAAATTTAAAAATAAATAAATAAAACATTTTAAAA
AATTAAGAAGATATAACCTATACATATTAGATTGGCAGATATTAAACAGACTAATAATACCAATTGCTGG
CAAAGATATAGATCTTATCATATATTGCTGGTTTAAACATGACTTATCATAGCTTTTTTGGAAAGCAATC
TAGCAATATTTAGTAGAATTTAAAATACCTTCTCACCCAACAATCTCACATCTGGGACTCTATCCTAGAG
AAATGAAAGCACTAGTAAGAGAGATCCTTGCAAACATATTTATTGCAGTGTCGTTCATTGGGCAAAATTT
GAGAAACAGAATCTGTCCATAAAAGTGGAATGGCTGAAAAATCTGTGGTGTAGCCACATCATGGAATATT
ACATGGACACTAAAAAATAATGAATTAGGACTATGCCAAGTGACTTGGAAGAAATTCCATGAGGCATTGT
TGAGTTAGAGACATGTAGAGGCTGGGCGTGGTGGGTCATTCCTGTAATCTCAACACTTTGGGAGGCCAAG
GCAGGCGGATCATGAGGTCAGGAGCTCGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAA
AATACAAAAATTAGCTGGGCGTGGTGACGTGCGCCTGTGATCGCAGCTACTCAGGAGGCCGAGGCAGGAG
AATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGCGA
CAGAGTGAGACTCCGTCTCAGGAAAAAAAAAAAAAAAAAGAGACATGTAGAGAAGTATGCACAACATGAT
TACATTATCAATGTTCTGTGTGTTGTATGTGTACATATAAAATGGCTATCGCTATACATGTATAGTATAA
CTAAGAGCATTGATAAAATATGCAAGAAAGCATCATAAATTATCAACCAGTTATCTTGGGAGTAGGGGTG
ATGTGGGTGATGGTAGGGTGGAGAGGGAGCCAAAAAGGAAAGGGGAGAAAACCCACTGCATGAAAACCCA
AACAGGGCACATGCTACGGCCACATGAATGAATTTACGCTAAATTATGTATGTGTGGTATAATTTTGTGT
GTAATATGTTTTATTTATAATTAAAGAAAATGTTTTTTAGAGACAGGGTCTCATTTTGTTGCCTAAGCTA
GAATGCAGTGGCACGATTATAGCTCATTGCAGCCTCCAGCTCTGGAGCTCAAGTAATCCTTCTGCCTCAG
CCTCCCAAGTGGCTGGGACAACAGGTATACATGAAAATGCCTGGCTAATTAAAAAAAAATTTTTTTTTTT
TTGTTACAGACAGGGTCTTACTTTGCTGCCCAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCTCCTG
CCTTGGCCTCCCAAAATACTAGGATTATAGGTGTGAGCCACTGTGCATGGCCTAAAAGATTTTATATATT
AAAAAAAAAGCAAACCCAAGTCGCTCTAAACTCCAGACTCTATGCTATTTTCATCTCTCTGAAGGGGATG
GGGGAAGCTTTTCACTTTGGTTACATGTCAGCCCGTACTCACAGAACCCTTTAACAGTGTTAAGTGCAGA
TCTGATGGCTGATCCAAGTTGGCTCTGAATTTACCCTTCTCACCTTCCCCTCAAGCTAGACCAGTGATAC
TCAAGCAGGGGTGATTCCCTCCCTGCCAGGGGACATTTGGCAATGTCTGGAGGCATTTGGATTGCCGCGC
CTGTGGTGGGTGCTACTGGCGTCTAGTGGGGAAAACAAGGGATACTGCTAAACACCCTTCAGTGCACAGG
ACAGTCCCTCCCACGCCCAACAAAGAATTCTCCAGCTGTCAACGTGAATAGTACTTGAGAAACCCTGAGT
TAGTCTGACCCAGTCACTTTACTACTGCCAGGTACGAACTGCATTTCCCGCCTCCATGGCACTGCCCATT
AGCATGCTCTCTCTACACCTGTTTGCTTACCCAAATCTACTTTTTTTCTTTTCTTTTTTGAGACAGGGCC
TCACTGTTGCCCAGGCTGGAGTGCAGTGGTGCAAACAGGGCTCACTGCAGCCTCAACCTCCTGGACTCAA
GTGATCCTTCTGCCTCAGCCTCCTGAGTAGCTGGTACCACAGGCATGTACTACCACCGTGGCTAATTTTT
TTTTTTGCATTTTTAGCAGAGACTGGGGTCTTGCTATGTTGCCCAGGCTGGTCTCGAACTCTTGGCTGTA
AGCAATACCCCTGCCTCGGCCTCCCAAAGTGTCGGGATTACAAGTGAGACCCACAGCGTCTAGCCTCAAA
TCCACTTCTTTCTTTTCTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGT
GATCTCGGCTCACTGCAACTTCCCTTCCTGGGCTCATGTGATTCTCCAGCCTCAGCCTCCCAAGTAGCTG
GGATTACAGGCATGTGCCACCAAGCCCAGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCGCCACG
TTGGCCAGGCTGGTCTCAAACTCCTGACCTCATGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTA
CAGGTGTAAGCCACAGCGCCCGGCCAAATCCATCTCTTTCTAAGGCCTGCCTCCCTTGTGTATCTTCCTT
AATAATCCTAGCCCATCTATCACAATCACTTTTGTCTGAATTCTTACAAGCTCATCAGGTATTTATGGGC
CTTCTGACACCACTTACATTGTAATCCAAATACCTTTTTAGCTCTTCTAATGCTATTACACTTCCCTATG
TTTTTATGCCTTTTCTACCCAACTAGATTTATAAGCTCTCAAGGAACACTTATCAGAGTGCTTTGCAAGC
TGAAGGTCCAACATTCTTAATTGGCCAGAATCTCTCTTCAGAGGAAAATAGGACACCCACCTTGGGGGCA
ATGCGGACTCGCTTGCTATGGCGGGCAAGCTCTGAGCTCATGAGGGAAGCCGCCAGGGGCAATGGCACCT
TCACCGAGGGCTGCAACACCAGTGACTGGTTCACCGGGAACTGGATAGGTACCAGGTATGAGCTGACCCG
TGGTAGCAGTGGCTTCATCTTCCGCCCTAGGAGGAAACACGAGAGATCAGGAGCAGGGGGACTGGAGTAC
ACCCCTTCTCAGCCCCAGGAGCTTTGCTCTCCTTCTCTGGGCTCAGATCCCTTTGAGGTGGGAACAGAAT
CCCAGAGTCTGGTTCCCTAAAGATATGGCCCCAGAACAAGGACCAGGCCCAAGGCCCACTCTCCCATACT
AACGTGCGCCCAGGGGGAGTTCGGTTTTGATGGTCATGTTCCGGCGGAGCTCTGGATTCGGTCGTTTCTG
CTGCTGCTTGTGGCAGATGGGGAGAGAAAGAAACCTATGTTAACACAATAAGGTAAAGAGGGGATGGCAA
AACCCCACCAGCTGCTCTGGTGGTGTGTGCTTGAGTTAATGACAGCCCAGAGAGAGGAGGCCAACCTGAG
GGGATGGACGTAGGCGAGCAGTCTCCAAAACTGTGATGAGTGGGCAGGTGGGTGGCCTACAGACACATGA
TGGCAGAGTGGCACTACCGCTTCACCCACGTGTCCTCAACACCCCTGGGGGATGCCAGAGCAGGTAGCTA
TATGCGTGGCAAAGAAAAGCTAGGCACAAAAGTGAGCGAACGAACTGCCGCCCCTGAGGCTGGTGCCATG
CGCTTGTGGCTGCTGCAGCATGCTCCCCTGCTGTGCCCTGCTCTGCTCAGTGTGCCCTTGTGATGCCCAT
GGAAGGGGAGGGAAGTGGGTGTGTGCCTGACCCTCAGGGTGTTCTGTGTCTAGGGCTGGCACCTAGACAA
AACATGGCCATAGGGACCCTTCCCCACATCACATCTTGTCTCTGTCCACTAAAGCCATGCTGAGCAGTGA
AAGGAAAACAAGGCCAAGCCCCGAGCCAGAGGGAAAGAACCTTACTGATTCCAAGTGCTCGGGCAATTGT
GGAGACCCTGGGTCCAGTGGCTGGTGGCGGCCAGGCATTGTGGGAGAGAAATGAGATGAAGTTACCACCA
ACGTGGTCAATTTGACCGGATTGGGAAAAACACTTATTCCTGACTGATGACAAAAGACACCCCAGACAAC
TGCCCCTCCCAGGAGAATGGTTACAGCTACCAGCAGCCTTATGGGCACTCTGAAAAACCAAAATAACTTC
TTTCTGAAAAGACGTTCTGGTAGCTCAGCTTCTGGTCTCCAGCCTAAGGCAGGCTTTTTTTTTTTTTTTT
TTTTTTTTTTGAGACAGACTTTCACTCTTATTGCCCAGGCTGGAGTGCAATGGTGCGATTTCAGCTCTCC
ACAACCACCGCCTCCTGGGTTCAAGGGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCAT
GCGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGT
CTCCAACTCCCGACCTTAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCC
ACCACACCCAGCAGGAAGGGCTTTTTTTAGAGCAAGCATTCCCAGAATTTCTTGTAAGAATCACCTGAGA
TGCTTGCTAAAAATACAAATTCCTGGGCCCATCCCAGAAGCACTAAATCAAGAGCCCCAAGAGAGGGGTC
TGGGAAGCTGTGTTTTAACAATGTCCCAGGCAATTCCCATTCACAGGGAAGTTAGGAAAACACTGCCCTG
GGGAGCCCTTTCTGTTGGGTCAGAACAGCCTTCTCCTTGCTCTGGTCTGGCACAAAAATGTGTCATTTGG
TATTTGTCAAGTGTACTTAATTCACTGGGTTTTGTGCAAGTCACTAATTGGGTGGCTGGCTTCTAACTCT
CCCCTGATCAAATGAAAGCATCACTAGCAGAACTTGTTTCCTTTTGAGATGGCTATGACAACCTCCAACT
TAGGCCCTATTTAGAGGAAAGCAGGGCATTCACCTTAAACACCTGGTCCAATGTCAAGTAGCGGTTGGCA
CTGGGGTGAATGGTCCAGAAGGAGACCTTGCCATTGGCAGACGTCTCCCGGACAAACATGTCGTGCAGGG
AAAGGTTGTGGCGGATGGAGTTCTGGAAGAAGAGCAAGACAACTGGTTATCAGCTACTTTAGATTCAGAA
ACATCACCCTTCAAACACATGGGGAAACCAGCCTCAGGCCCCTCCCACTGTGCTCAGCACAGGCTTCGTC
TGGTGTCTTTGCAGCCCTCTTGGCAACTCTCCTGACACTCCACACCGCAGAGCCGTCACCTTCAGCCATA
AACCCATCTATTCTACGGGAATAAAGACTGATGCCAACCTTAGATTGTGATAAAGAAAAGACCTAGATAG
CTGTCAGGGGCTAGAAAAGCAGAGTAAGGCTGTGAGGTAGTGATCAATAGCAAGAAAGGTGGCTCAGAGA
AATTAAGAAACTAGGGAATTAGGCCCGGCGTGGTGGCTCACGCCTATAATCCCAGCACTGTGGGAGGCCA
AGGTGAGTGGATCACTTGAGGCCAGGAGTTTGAGACCAGCCTAGCAAACATGGTGAAACCCTGTCTCTAT
CAAAAATATAAAAATTAGCCAGGCATGGTGGCGCATGCCTTTAGTCCCAGCTACTCGGGAGGCTGAGGCA
GGGGAATCACTTGAACCTGGGAGGCAGAGGTTGAAGTTAGCCAAGATCATGTCACTGCACTCCAGCCTGG
GTGACAGAGTGAGGCCCCGTCTCAAACAAACAAACAAGAAACTAGGAAATTAAGGCTGGGTGTGGTGGCT
CACGCCTGTAATCACAGTGCACTGAGAGGCTAAGGCAGGAGGAGTGCTTGAGACTAGGAGTTCAGACCAG
CCTGGGCAACATAGTAACCAGCCTGGGCAACTGTCTCTACAAAAAAAAAATTAGCGGACTGTGGTGGTGC
ACCTGTTATCCCAGCTACTTGGGATGTTGAGGAGGGAAGAGCTTGAGCCCAGGGGGCTGAGGCTGCACTC
CAGCCCAGGCAACAGGGTGAGACCCTGTCTCAAAAAACAAACAAACAAAAAACTAGGAAAGTAAGCTGAT
GGAAGGGAGTAAAATTAAAAGTTCTACCATGAATTAGCCAGGCGTAGTGGCGGGCGCCTGTAGTCCCAGC
TACTCGGGAAGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCG
CCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATCTCAAAAAAAAAAAAAACATAGTTCTACCAT
GAGGGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGTCGAGACGGGTGGATCATTT
GAGGTTAGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACACTGTCTCTACTAAAAATACAAAAAAAT
TAGCCAGGCGTGGTGGCGCATGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAA
CCTTGGAGGCGGAGGAGGTTGCAGTGACCTGAGATCTGCCATTGCACTCCAGCCTGGGTGACAGAGCGAG
ACTCTGTCTCAAAAAAAAAAAAAAAAAAAAGAAAGAGTTCTACCATGAGGAAAACAAAGCACACTTGACT
TGGAATTGAGCACCCGTCAGAAGACCTCATTTGTGGCTCTGACACCGACCAACTGCGTGAGCTATGTTGA
CTCACAGGCATCTCGGTCTTTCCATGAATGAAGTGAAAGGAAAACCCCTGCCCACTAGAAATGCTATGTG
ACGCTACAGGAGATGACATCTTGGGTCATGAGGCTCACAGACAGCATTTTTTTTTTTAATCAAGACATTT
TCATAAAACTACTTAGCCACTCTAGCTGCTGGCATCTAGGACGGCTGTTGAGTGTAGCAGAAAAGTGGGC
TTGAGTGCTACATTGAAGACCCTCCATGGACTTTAGGTAGTAACACATGAAGTAGTTAAGGAGCTCTTCT
TAATGATTTTGCCTGGATTCAATAAGATTGAGTCACAATCTAAAAGATACATTTGTTTATCATTCTAGTG
TCCTTTGCACTTAACTGCTGTCCCAGATACAAGTTGCAGTACAGCACTGGAGAGACTGTCAGGCTGGGCT
GACCTTGATTTTGGTTGCTGTGGGACACATTACCTTCCAGCCTGGCTTGGCAATGTGCTTAAAGTAGGGA
AAGTGGTCCTCAATCCACGTATAGATGTCTTTCAAAGTCATGCGCTTCCTCTCAGTGCTGTTGATGGCGA
ATTGTATCATGGCCATGTAAGAGTAGGGTGGCCGCTCAGACACAGAGTTCTGCCAGGACGCTGATGGTCT
CGAAGGCTCCTCAACCTGAGGGTTATGACACAGGGAATGACATGAAAGAGTTCATGAGAAGCACCCCCAA
CCCAAGCCCTTGAAGAACATCTAGAGAAACCTTTATCCCATAGGACGGTCTAGAAACAAACTCATCTGAG
ACCACTATCTCATAGAATAAAATTTTAGAGTTGGGAAGAATCTTGGAGATGATCTAGCCTAGACCCTAGC
CAATAAGAAACTGGTTTTGTCATCCATCATTTTGTTGAATTTGGAGAAAATCCAGTCCCTTCCAGTTGAA
ATTTCTTAGGAAAGTTTGAGTATGTACTTTGATTCTCAAAGCATTGATGTTACACTAAAACCACGCCCGT
TTTTCAGACTTTTGGGTCTAGAAACCTAGGTCTTAGTCCCATTTCTGTTCCTGATGTGCTGTGAATAAAC
GCATCTCATTTCAATGTTTGTATGAGAGAAACATTCTCAAGACTATGAGTCAGACAATGTCTGCAAAGCA
CACAGTTAGCTAAGTTTTAGGCAAAGAGCTGATCAATCACATTTCTTTTTCTTTTTTTGAGACAGGGTCT
CACTGTGTCACCCAGGATAGCGTGCAGTGGCTGGATCACAGCTCACTGCAGCCTTGACCTTCCCAGGCTC
AGGTGATCCTCCTGTCTCAGCCTCCAAGTAGCTGGGACTACAGGCATACACCACCACGCCCAGCTAATTT
TTTTTTTTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTACAATGGTACGATCTCGGCTC
ACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCTGCAGCCTCCCAAGTAGCTGAGATTACAGG
TGCCTGCCACCACGCCCAGCTACTTTTTTTGTATTTTTAGTAGAGATGGGGTTTACCATATTGGCCAGGC
TAGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAGAGTGATGGGATTACAGGCATG
AGCCATTGCGCCTGGCGATTTTTTTTTTTTTTTTCGTATTTTTAGTAGTAGAGACCAGGATTTTGCTATG
TTGCCCAGGCTGGCCTAGAACTTACGGGCTCAAGCAATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGAT
TACAATTGTCAGCCGCTATGCCCGGTCTCATTCACATTTTTAAAATTGGAGATATTACTTTCTAAAGTAC
ACAAATTTTATGTATATAGCACAATTAATATTTACTTACATATACACGCATGTAAATTTTCACTTTTTTT
TTTTTTTTGAGACAGAGTTTCACTTTTGTTGCCCAGGTTGGAGTGTAATGGCACGATCTTGGCTCACCGC
AAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCATGT
ACTACTGCACCCAGCTAATTTTGTATTGCTAGTAGAGGCGGGGTCAGGCTGGTCTGGAACTCCCGACGTC
AGGTGATCCACTCACCTTGGCCTCCCAAAGTGCTGTGATTACAAGCATGAGTTATCGCGCCTGGCCAAAT
TTTCACTTTTAAAGATTGTTGAGCTGGAGGCTATGATCCTAAGCGATTTAATGCAGGAACAGAAAACCAA
ATATTGCATGTTCTCACTTATAAGTAGGAACTAGGCTGGGTACGGTGGCTCACGCCTGTAATCCCAACAC
TTTGGGAGGCTGAGGCGGGTGGATGACGAGGTCAAGAGATTGAGACCATCCTGGCCACCATGGTGAAACC
CCATCTCTACTAAAAATAAAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTATAGTCCCAGCTACTCGGGA
GGCTGAGGCAGGAGAATCACTTGAACCTGGGATGCAGAGGTTTCAGTGAGCAGAGATTGTGCCACTGCAC
TCCAGCCTGGCAACAAAGAGAGAATCCGTCTCAAAAAGAAAAAAAAAGAGGCCGGGCGCAGTGGCTCACG
CCTGTAATCCCAGCACTTTGGAAGGCCAAGGCAGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGG
CCAACATAGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGCAGCGGGCACCTGTAA
TCCCAGCTACTCAGAAGTCTGAGGCAGGAGAATCACTTGACCTGGGAGGTGGAGGTAGCAGTGAGCTGAA
ATCGCAGCACTGCACTCCAGCCTAGGAGACAGAGAAAGACTACGTCTCAAAAAAAAAAAAAAAAAAAAAA
AAAGCAGGAGCTAAACATTGAGCACACATGGATATGAAGAAGGGAACACTAGACACCAGGGCCTTCTTGA
GGGTGGAGAGTGGGAGGAGGGGGAGACAGAAAAACTACCTAGCAGGTACTATACTCACTACCTGGGTGAC
AAAATCATTTGTACACTAAACCCCAGCGACACACAATATACCCATGTAACACACCTGCACATGTACCCCC
TGAACCTAAAATAAAAGTTGAGAAAAAAAAGAAAATAAAGGTTGAATGAGTGATTTACACATATATACAA
TAGAATCTAGATGTGTTATATTGGTAACTGTGGGAAAAAAACCCAGACTACACAATTGGGTTAGATCAAT
TTTGATTGCTAGAGAAGTATTTAAAATTCGTATCTAGGCCAGGCTGGTGGTTCACGCCTGTAATCCCAGC
CCTTTGGGAGGCTGAGGCAGGAGGATCACTAGAGCCCAGGAGTTGAAATCAGCCTGGGCAACATAGCGAA
ACCCCATCTCTACAAAAAATACAAAAATTAGCTGGGCATGGTGGCATGCACCAAGCTGGCAAGTCCCAGC
TACTTGGAAGACTGAGGTAGAAGGATCAGTTGAGCCCTGGAGGTCGAGGCTGCAGAGAGCCATGACTGCA
CCATTGCGCTCCAGCCTGGGCAACAGAGCAAGACGCTGTCTTAAAAAAAAAAAATATATATACGTGTATA
TATATAACTGACTTTATCTGCTATTAATATTATATCTTCTAATAAAATTAACTTGTTGTATTCTATTCAA
TTCATACTGTTCATACTGTTGGGAAGCATCTTTAAAGTTCAGGTGGATTCCCAAAATGAAGACCTCTTAA
TCATTTCCTGAATACCTACTAAGGACAAAATACTAAACCCAGTGCTGGCTGGAATACAGAGTGACCAAGG
GACTCTGCCCTCAAGGAAATTTCACAGATGGGAGAGAAAAGATCCCAGGCAGAAAAATAGCTCAAAAGTT
ATGCAGAATAGCATGAAGTGGAGAGCTAATACCAGAACTTGGAAATTCTGGTCCATCAGGCCACTTGATC
CATTTCCCTACCTAGGAATTCCCTACACTGGATCTGATTTCTTTAGTGAGGGACGGAACAATTCACCTTA
ACCTGTCGCTGCTCCAGGTGACAATTCTCCTTTTCCTCCATCTCTTGCTTGATGCTGCGGGAGCCCAGTC
CATCAGAACTCATCTTTCGAAGCCACTGGATGTTGGATAGGCTATTGTTGATAGTGCAGCCTGCTGCCTC
ACCATCTGCTAGAGGGAAAATAATCCAACACCCCACTTAGCTGCCTCATCAGATGCCCAGGTGTGTCCAT
CAGAATTGGTGGCTAGCAGGCCGGGTGCAGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGGCGAGG
CGGGTGGATCTCCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTCTACTAA
AAATACAAAATTAGCTGGGTGTGGTGGCACACGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGACAGGAG
AATTGCTCGAACCCGGGAGACGAAGGCTGCAGTGAGCCAACATTGCGCCACTACACTCCAGCCTGAGTGA
GACTCTGTCTCAGAAAAATAAAAAATAAAAAAGAAAGAATTGGTGGCTAGGGATCACTTGTCCAAGACCT
CTGCCTTTAGGGACGGAGAACACATGCTGAATCTATTGTGGCTCTAAGTTACTCTGCCCCATTATGCATT
TCAGGACAAATTTAGGAGCATAGTTCAAATTGCATTTCAAGCTGAGCCACACTGAGCCTTAGAGATCAAT
CAAGGCAGGCTTACAAAAGAATTATTGAGATATGCACACCAAAAAAGTCACTTTTCAGCCTGGGCAATAT
AGTGGGACCCCATCTCTGCAAAAAGAAAAAAAAAATTAACTGGGAATGATGGTGCATGCCTATAGTCCCA
GCTACTTGGGAGGCTGATGTGGGAGAATGGCTTGAGTCCAGGCATTCGAGGCTAGAGTGAGCCGTGATTG
CGCCACTGCACTCTAGCCTGGGTGACAGTGCGAGACCGCATCTCTAAAGAAAAAGTCATTTTCCTCCTCT
TGCTTCAGTTTTCTCCTTTATCAAGAAGGAAAATGAGGCCAGGCGCAGTGGCTCACACCTGTAATCCCAG
CACTTTGGGAGGCCGAGGTGGGCGAATCACCTGAGGTCAGGAGTTCAAGACCAACCTGGCTAACATGGCA
AACCCCTGTCTCTACTAAAAAATACCAAAATTAGCCAGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTAC
TCAGAAGGCTGAGGCAGGAGAATCACTTGAACCCAGAAGGTGGAGATTGCAGTGAGCTGAGATTGCACCA
CTGCACTACAGCTTGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAGAAGGAAAATG
AAGTCAGGCGCTGTCGTTCATGCCTATAATCCCAGCACCTTGGGAGGCCCATATGGTTGGATCCCTTGAG
CTCAGGAGTCCGAGACCAGCCTGGGCAACATAGTGAGACCCCTTCTTCATTTATTTATTTTTGAGACCCC
TTCTTTTTTCATTTTTATTTTTTTTTTTGAGACAGAGTCTCCCTCTGTGGCCAGGCTGGAGTGCAGTGGC
ATAATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAGCGATTCTCCTGCCTCAGCCTCCAGAGTAGC
TGGGACTACAGACGTGTGCCACCACGCTCGGCTAGTTTTTTTATATTTTTAGTAGAGACGGGTTTCACCA
TGTTGGCCAGGCTAGTCCAAACTGCTGACCTCAAGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGA
TTACAGGGATGAGCCACTGTGCTCGGCCAGAAGCCTGACTGTTGTAAGCATCAAGACTGACTACACACCT
TGCCACTACAGAGGAAAGGCTGGGCTCCCTCACCCCTTTCCCTGGAAGACCACATACCACAGGTCTCCCG
TTTCTGCTCGCAAAGGGCTCCAGGTGGTCTAGGAAGATTCACATCCCTAGCTGCAGGTTTTGGTCCCAAG
GTCTCCAGGGTCACTTCTGTCCTTTTGGCATCATAGCTGGTTTGGGTTTGAGGCCGGAGTCCTGGAGGCT
GAGTTGGGGCTCCCCCACAGCTGATGAGGATGAATTTGTTGGGCCCACTACTGCCACTCTCTTTTCCCTT
GGCAGTCAGTGCTGTGATGATGCTGTGAATATTAGCATTGTTGGGGATGGCCACTACTTGCGTGTTGGGC
ATGGTGGGGTGGTTAATAATCTTGATCCCAGCTGGAAACTTGCAAGAGTTGGACTCTGCCACTTCCTTGG
AGGCCTCTGCTTGATTAGACTCCTGTTGGGCAGGGGATCTCTTAGGTTCCTCCTCTGATGTTTCACTTGG
GGCATTTTGAACAGGAAGGGGCAGCCTCCGTCTTTTGAGAATCAGTGGCCGACGGGGGCTAGTTTTCATT
ATGAATCTGCGTTTTCACTCTCCATTGAGAATCACAAGTGTGGACCCTGGAAAATGCAAATAGTGGCAAG
ATGTTAGAGATTGTTTAGGCTGAGAAGAGGTCCTTTTAGAGAAAGGTGCTCCTCTTTATATGACCAGGAA
CATGAGCCTAAAGGCCCAGGTAAACATTCCATGGACTTTTGTAAAGACCTCAGATAATAAGGAGATAAGC
TTTACTGACAAAAGAAGGCTAAAATTACAGCAGACAGAAGCAATTCAAAGGGCAAAAATGGGACTGGGTT
GGAGATAAGACAAAGATCTCCTTGAAGCTTCAGAATATTTGGCTACAGAAATGGATGGGATAGCTACAAA
TATGTGGAAATCTCTATAATTGCCTACTATAATATAAATAGATCACTTGCAATGACTGTATGGACAGAAA
TGGAAGATGCTAGAATAGGAAAGCATATGGTAATTAGGAGTCCTGATGAAACTCTGATCCCATAATCCAT
TCAAGACAAAGGATTTTAATTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCACCCAGGC
TGGAGTGCAGTGGCACGATCTCAGTTCACTGCAACCTCTGCCTCCTGGGTTTAAGCGAGTCCCACGTCTC
AGCCTCCTGAGTAGCTGGGATTACAGGTGCCCACCACCACGCCCGGCTAGTTTTTGTATTTTTAGTAGAG
ACAGGGTTTCACCATGTTGCTCAGGCTGGTCTCAAACTCCTGACCTCAGGTCATCTGCCCGCCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGTCTGGCCAAGCCTTTTGATTTTTATATTACTTTG
TAAATAGGACCAGTGCACACAGAATCAGGGAAGAAAGGCAGATTGTACTATTGCCACACTACTGGAAAAA
TCATCTCCCAGTTTACAAAACCTCACATAAAATGGAAACCTCTACTGAAGGCCCATGTAAAGTTGTGCAG
CTTGTGCACTGAACAACTCTAGAGGGTGACATTTATTTCACAGGCTATTATACTTGCTCTAATTTAAAAA
GCATGTTTTCTTTTACAATTTGTATTGTATTTATACAGTGGCATTTTAGTACTTGCATGTGGTTATATAT
ATTTTAACTAAGCATGCCACTTTATTAATTTCTTTTCCAGAAATAAGACTATAACCCCTGTCTTCTTAGT
ACCACAATGAGCTATCATCATTACACTAAGGTGGTTCTGAAATGCTAACAGTGTAGTCTTTTTTTTTTAA
GTCTTTTGTTGATTTTTTTTAATTTTTTTTTTTTTTTTGAGACGGAGCTTCGCTCTTGTCACCCAGGCTG
GAGTGCAATGGCGCAATCTCAGCTCACTGCAACCTCGGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAG
CCTCCCGAGTAGCTGCAATTACAGGCATGCACCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTTAGTA
GAAACAGGGTTTCACCATGTTTGCCAGGCTGGTCTTGAACTCCTCAGGTGATCCACCCGCCTCGGCCTCC
CAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTTTTGTTGATTTTAATAGATACATGGAAT
ATTCTACCATTAAGCAAAATTGTGTAATTCTATTTCACGGAACTTTGGAAGACAGAGGAATTGGCTGTCT
CTTTTTTAGGACACTTATTCTCTCCCTGAAAAGCAACTGCACTTTTTTGACATTTGTCATCTGCATAGAG
TTCACAGGCCCTCCACACCTCTACCTTCAAATCTCAGTTTTACTTTCACCTCCGATCTTTCCAGGCTTCC
CTCTCTCCCCGCATCAATCAGTAGATATTATTCCTCTTTTTCCACAGGATATCTAAGTCTTAATTTTCTC
TTCTACTTCCTGACCAGCCCGTTATTATTATTGCCAACACTTTCTTGCCCGGGAAACTTCCAGAGTGGCT
CCTCCGACCCATCCCCATCCTGAGCGGGGAAATCTTGCTACATTCTCAAGAACCAGGAAAAGGGCCCTGC
AAAAGGGTAAGTAAGATGGAGGCGGTGTTGCCTAGTGGTGAGACAGCCTGGGAGCAGGGGAGTGTGTATG
CAGGTTGGTCTTTGACTCAATGTAGTACAATCTCAGTCTTCATCTCAGCCACAGTCGGCCTAAGAAGGTA
GGCCACCCCAGCCCTCCCGAGGCCGCGGGCAGGGTGCGGAGGTCAGACTTCCAGGGAAGGCCAAGGGGCG
CTTTAAGCAGTGAGAAGGCCACGGCCAGGAGGTGGACGCAGAAAAAACTTGCACCCTGGCTCAGATTCTT
CCCGTGTGACCCAAATCTCCACTCGTGGCCCGTGCCCTGCTGCTAGACGCCCTGACCTCCGCGCCCGGAG
GCCTTGCTCCCCGCCTGTGCCCAGGCCAGGCCTGGGACTCCATTGCTGCATCCCGCTCACCTCCAGACTG
CAGTCGCCGCCGCCGTTAGGCCGTAGCTCCGAAGGCGGGCTCCGGGCTCCTCCAACCTGGGGGCCGAGCC
AGGGCCCCGGACGGGGGCTCGCGCCGGACCGGCCGGGTCCCCGGCGGTGCGGGCGGGGTGGGAACCCCGG
GGGATCCCGGGAGGGGAGGGGGTCCCGGGCCGGGGCCGGGGGTGGGGTCTGGCACCGGAGCTTTCAGTTT
GTTCCGCTGTTTGAAATTGGCGCCGGCGGAGCGTT
|
| Protein Name |
FOXM1_HUMAN |
| Length |
763 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
30-MAY-2000 |
| Definition |
RecName: Full=Forkhead box protein M1; AltName: Full=Forkhead-related protein FKHL16; AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 11; Short=HFH-11; Short=HNF-3/fork-head homolog 11; AltName: Full=M-phase phosphoprotein 2; AltName: Full=MPM-2 reactive phosphoprotein 2; AltName: Full=Transcription factor Trident; AltName: Full=Winged-helix factor from INS-1 cells |
| Primary Accession |
Q08050 |
| Accession Version |
Q08050.3 |
| Other SeqIDs |
sp|Q08050.3|FOXM1_HUMAN,gi|12644391 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Mar 21, 2006 this sequence version replaced gi:74739278, gi:1362866, gi:8134470.; [FUNCTION] Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.; [SUBUNIT] Interacts with PINT87aa which is encoded by the circular form of the long non-coding RNA LINC-PINT; the interaction inhibits FOXM1-mediated transcription of PHB2. {ECO:0000269|PubMed:33754036}.; [INTERACTION] Q08050; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-866480, EBI-11524452; Q08050; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-866480, EBI-16429296; Q08050; P24864: CCNE1; NbExp=2; IntAct=EBI-866480, EBI-519526; Q08050; P35222: CTNNB1; NbExp=16; IntAct=EBI-866480, EBI-491549; Q08050; P14868: DARS1; NbExp=2; IntAct=EBI-866480, EBI-358730; Q08050; O43524: FOXO3; NbExp=2; IntAct=EBI-866480, EBI-1644164; Q08050; A0A455ZAR2: LINC-PINT; NbExp=4; IntAct=EBI-866480, EBI-27121529; Q08050; Q13416: ORC2; NbExp=2; IntAct=EBI-866480, EBI-374957; Q08050; O00541: PES1; NbExp=2; IntAct=EBI-866480, EBI-1053271; Q08050; O75152: ZC3H11A; NbExp=2; IntAct=EBI-866480, EBI-748480; Q08050-1; Q00534: CDK6; NbExp=2; IntAct=EBI-866499, EBI-295663; Q08050-1; P03129: E7; Xeno; NbExp=3; IntAct=EBI-866499, EBI-866453; Q08050-2; B4DE54: BANP; NbExp=3; IntAct=EBI-5237510, EBI-16429313; Q08050-2; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-5237510, EBI-11524452; Q08050-2; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-5237510, EBI-16429296.; [SUBCELLULAR LOCATION] Nucleus.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=3; Comment=Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human.; Name=1; Synonyms=FoxM1C, FOXM1-c; IsoId=Q08050-1; Sequence=Displayed; Name=2; Synonyms=FoxM1B, FOXM1-b; IsoId=Q08050-2; Sequence=VSP_001547; Name=4; Synonyms=FoxM1A, FOXM1-a; IsoId=Q08050-3; Sequence=VSP_001548.; [TISSUE SPECIFICITY] Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.; [DEVELOPMENTAL STAGE] Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression pattern: intestine, colon, testis and thymus.; [INDUCTION] Induced during liver regeneration and oxidative stress.; [DOMAIN] Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.; [PTM] Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488}.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/FOXM1ID40631ch12p13.html'.; [WEB RESOURCE] Name=NIEHS-SNPs; URL='http://egp.gs.washington.edu/data/foxm1/'. |
| Source Db |
UniProtKB: locus FOXM1_HUMAN, accession Q08050;; class: standard.; extra accessions:O43258,O43259,O43260,Q4ZGG7,Q9BRL2; created: May 30, 2000.; sequence updated: Dec 1, 2000.; annotation updated: Oct 12, 2022.; xrefs: U74612.1, AAC51128.1, U74613.1, AAC51129.1, U83113.1, AAC63595.1, DQ022289.1, AAY26401.1, BC006192.2, AAH06192.1, BC006529.2, AAH06529.1, BC012863.1, AAH12863.1, L16783.1, AAC37541.1, B36881, NP_001230017.1, NP_001230018.1, NP_068772.2, NP_973731.1, NP_973732.1, 3G73_A, 3G73_B, 7FJ2_A, 7FJ2_B, 7FJ2_E, 7FJ2_F; xrefs (non-sequence databases): CCDS:CCDS8515.1, CCDS:CCDS8516.1, CCDS:CCDS8517.1, PDBsum:3G73, PDBsum:7FJ2, AlphaFoldDB:Q08050, SMR:Q08050, BioGRID:108594, CORUM:Q08050, DIP:DIP-36754N, IntAct:Q08050, MINT:Q08050, STRING:9606.ENSP00000342307, BindingDB:Q08050, ChEMBL:CHEMBL4739852, iPTMnet:Q08050, PhosphoSitePlus:Q08050, BioMuta:FOXM1, DMDM:12644391, CPTAC:CPTAC-1242, EPD:Q08050, jPOST:Q08050, MassIVE:Q08050, MaxQB:Q08050, PaxDb:Q08050, PeptideAtlas:Q08050, PRIDE:Q08050, ProteomicsDB:58567, ProteomicsDB:58568, ProteomicsDB:58569, Antibodypedia:4507, DNASU:2305, Ensembl:ENST00000342628.6, Ensembl:ENSP00000342307.2, Ensembl:ENSG00000111206.13, Ensembl:ENST00000359843.8, Ensembl:ENSP00000352901.4, Ensembl:ENST00000361953.7, Ensembl:ENSP00000354492.3, GeneID:2305, KEGG:hsa:2305, MANE-Select:ENST00000359843.8, UCSC:uc001qle.4, CTD:2305, DisGeNET:2305, GeneCards:FOXM1, HGNC:3818, HPA:ENSG00000111206, MIM:602341, neXtProt:NX_Q08050, OpenTargets:ENSG00000111206, PharmGKB:PA28236, VEuPathDB:HostDB:ENSG00000111206, eggNOG:KOG2294, GeneTree:ENSGT00940000158804, HOGENOM:CLU_027498_0_0_1, InParanoid:Q08050, OMA:SWQDSMS, OrthoDB:1270467at2759, PhylomeDB:Q08050, TreeFam:TF333250, PathwayCommons:Q08050, Reactome:R-HSA-156711, Reactome:R-HSA-69273, SignaLink:Q08050, SIGNOR:Q08050, BioGRID-ORCS:2305, ChiTaRS:FOXM1, EvolutionaryTrace:Q08050, GeneWiki:FOXM1, GenomeRNAi:2305, Pharos:Q08050, PRO:PR:Q08050, Proteomes:UP000005640, RNAct:Q08050, Bgee:ENSG00000111206, ExpressionAtlas:Q08050, Genevisible:Q08050, GO:0000785, GO:0005654, GO:0005634, GO:0003677, GO:0003700, GO:0000981, GO:0019901, GO:0000977, GO:0006978, GO:0006281, GO:0000086, GO:0045892, GO:0032873, GO:0000122, GO:0008284, GO:0045893, GO:2000781, GO:0045944, GO:0051726, GO:0001558, GO:0042127, GO:0046578, GO:2000377, GO:0006357, CDD:cd00059, Gene3D:1.10.10.10, InterPro:IPR001766, InterPro:IPR042839, InterPro:IPR018122, InterPro:IPR030456, InterPro:IPR036388, InterPro:IPR036390, PANTHER:PTHR46878, Pfam:PF00250, PRINTS:PR00053, SMART:SM00339, SUPFAM:SSF46785, PROSITE:PS00657, PROSITE:PS00658, PROSITE:PS50039 |
| Sequence |
mktsprrplilkrrrlplpvqnapsetseeepkrspaqqesnqaeaskevaesnsckfpagikiinhptmpntqvvaipnnanihsiitaltakgkesgssgpnkfiliscggaptqppglrpqtqtsydakrtevtletlgpkpaardvnlprppgalceqkretcadgeaagctinnslsniqwlrkmssdglgsrsikqemeekenchleqrqvkveepsrpsaswqnsvserppysymamiqfainsterkrmtlkdiytwiedhfpyfkhiakpgwknsirhnlslhdmfvretsangkvsfwtihpsanryltldqvfkpldpgspqlpehlesqqkrpnpelrrnmtiktelplgarrkmkpllprvssylvpiqfpvnqslvlqpsvkvplplaaslmsselarhskrvriapkvllaeegiaplssagpgkeekllfgegfspllpvqtikeeeiqpgeemphlarpikvesppleewpspapsfkeesshswedssqsptprpkksysglrsptrcvsemlviqhrerrersrsrrkqhllppcvdepellfsegpstsrwaaelpfpadssdpasqlsysqevggpfktpiketlpisstpsksvlprtpeswrltppakvggldfspvqtsqgasdplpdplglmdlsttplqsapplespqrllssepldlisvpfgnsspsdidvpkpgspepqvsglaanrslteglvldtmndslskilldisfpgldedplgpdninwsqfipelq |
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