|
|
| Record Information |
| Record ID |
51 |
| Pubmed ID |
28855356 |
| SNP |
|
| Gene ID |
3383 |
| Protein ID |
P05362 |
| Vaccine Adverse Events |
injection-site reaction, flu-like symptoms, fever, diarrhea |
| Vaccine |
Poxviral TRICOM-Based Vaccine |
| Gene Name |
ICAM1 |
| Official Symbol |
intercellular adhesion molecule 1 [Homo sapiens (human)] |
| Aliases |
BB2, CD54, P3.58 |
| Other Designations |
intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; epididymis secretory sperm binding protein; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor |
| Chromosome |
19 |
| Location |
19p13.2 |
| Annotation |
Chromosome 19 NC_000019.10 (10271120..10286615) |
| MIM |
147840 |
| DNA Sequence |
>NC_000019.10:10271120-10286615 Homo sapiens chromosome 19, GRCh38.p14 Primary Assembly
GAGCTCCTCTGCTACTCAGAGTTGCAACCTCAGCCTCGCTATGGCTCCCAGCAGCCCCCGGCCCGCGCTG
CCCGCACTCCTGGTCCTGCTCGGGGCTCTGTTCCCAGGTGAGTCGGGGTGGGGATTGCCGTCGGGCCAGT
TCTCCGAAGCCCCGGGAGGACCGGCTCCCGGGTCAGGTCATGCATGCTTAGGTAGCTGTTTATGGGAAGG
AGGGGCTAGAGACAGCGATTGAAAGGCAACAGCCAGTAGGTTCGAATCCAGACCCTGCATACCTCCACGT
GTGGCCTTGGGCTATAGATTGCAGCTTTAAAAAAGGGTAGGGGGTTGGAGATGGAGGGGAGGGGCGGGCC
TCGTTTTGTTGCCCAGGCCGGTCTTGAACTCCGGGGGTCTAGCCTTACCTCCTGCCTCAGCCTCCCGAGT
AGCTGGGATGAGAGGTGTGAACCACCGCCTTGCTTGGCTAGATTGCGTCTCTTACAGTTTCTCAGCTGTA
AAACGGGAAACGTTATAGCGGCCACCTGGCAGGGTATCTTGGCCCAGCGCAGCACCTGGCCCCAGGACTC
GATCATGATGGTTTGGGAACTTGGCTCTGTGCCAACCCAACAAGGCTTAAGGGACCCCCACCCCCCTCAA
GATGTATATTCTGTTCCTCATCCTCTCTGCCCCTGGGGAAGTCCAGGGCTGCTTCTACTTGGGGGAATTC
CAGAGCTGACTTATCCGTGGCCCAAAGCTGAGAAGTGGGACGCCCCAGCACACCCTCCCCCAGCTCCAGC
CCAGCTAGGGAAGAGGGAAGGGGTCAGAGGGTCTTTCATGGTGGTGTAAGTTTGGGGAACCAGGAGGGTG
GGAGATTGACAGCTTGGTTAACAGCTCAACAAAGCCTGAGATCCAGGCCAGCACGGTAGTTCATGCCAGT
AATCCCAACACTTTAGGAGCCCCAGGCGGGCGAATCACTTAAGGTCAGGAGTTTGAGACCAGCCTGGCCA
ACATGGCAACATCCCGTCTCTACTAAAAATACAAAAATTAGCTGGCATGGTGGTGGGCGCCTGTGATCCC
AGCTGCTCGGGAGGCTGAGGGAGGAAAATCCCTTAAGCCCACGAGGCTGAGGTTGCAGTGAACCAAGATT
GTGCCACTGCACTCCAGCCTGGGAGACATAGCGAGATTCTGTCTCAAAAAACAAAGCGTTCTGATCCGGA
CTCAGACCCAGATCGCACTGCTTTCTAGCTGAGTAACCATTTCTCTCTATGAAATGGGAATGGTCCCAGA
ATCTCCCTTGGAGAATGTATGGAGCCAGTGTCCTCACACCCCCATCCAAGATAGAACAAATCTGAGACAG
GAATCTTTGAGTGAGGCAGTGCTGGGCTCAGACATTTTTTCCCACCTTCGGAGGCAGCAGAATCTGAGGG
ACCTGATCCAAATAAGCCCCTTCTTTCTTTCTTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTGAGACGG
AGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAG
GTTCAAACGATTCTCCTGCCTCAGCCTCCCTGAGTAGCTGGGACTACAGGCATGTGCCATCACACCCGGC
TAATCACTGTGTTAGCCAGGATGGTCTCGATTTCCTGACCTCATGATCTGCCCACCCTGCCTCCCAAAGT
GCTGGGATTACATGCGTGAGCCACAGTGCCCACCCCGTAAGCCCCTTCTTTCTTACCTGCAAGGTAGCCA
GTTGCTACCCATCCTGTGCTGAGTTACTTGTATTAGCAAGGGATGGGGTGGCTATACTCACCCACCTTAC
AGATGGGGAAATTGAGGCCCAAAGAGGGGGAAACTACGTGTCTCAGGGAGTGAGGAGCCAGTCTGATTCC
TGGAGGGCTGACTGTCTCCACCTGACTTCTTAGGAGGGAGGAGGGCACCAACTTCACATTAAAATCTGGT
TGGACACAGTGGCTCACACCTGTAATCCTGGCATTTTGGGAGGCTTAGGCGGGAGGATCACTTGAGGCCA
GGAGTTTGAGACCAGCCTTAGCAACATAGTGAGACCCCATCTCTACAAAAATGTTTTTCAGGGCCAGGCG
CGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATTACCTGAGGTCAGGAGTT
TGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAGTACAAAATTACCCGGGCGTGGTGG
CGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGT
TGCGGTGAACTGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGCTAAACTCCGTCTCAAAAAAA
AAAAAATGTTTTTCAAATATTAGCCGGGTATGGTGGTGTCCTGTAGTCCCAGCTACTTGGGAGGCTGAGA
TGGGAGGATCACTTGAGCCCAGGAGTTCAAGGTTACAGTGAGCTATGATTGTGCCACTGTATTCCAGCCT
GGGTAACAGAGGGAGACCCGTTTAAAAAAAAAAAAGTGATGGCTAAAGTCCTTCCATGGCTCCCTATTGC
CCTCAGTATAAAGAACACATGTGGCTGGGCGTGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCT
GAGGCGGGCGGATCACTTGAGGCCAGGAGTTTGAGAGCAGGCTGGCCGACGTGGCGAAACCCCGTCTCTA
TTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGCTTGCCTGTAATCCCAGATACTCTGGAGGCTGAGGC
AGGAGAATCACTTGAACCCGGGAGGCAAAGGTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGTCTG
AGTGACAAAGCGAGACTCCATCTCAAAAAAAAAAAAAATAAAAGAACACATCTTTAGCATGGCCTTCAGT
GCTCACGGGATCTTCCTGAATTAATCTCCCCCTCTTCATCCTTGCTCACTCAGCTCCAGCCACCCTGCCC
CGGGACATCTGTACTTGCCTGGAACTTATTTCCCTTTTCTCCGGACAGCCAGCCCTTTCTCGTCATTTAG
ATCTCTGCTGAAACATTACCCTGTCACCAAAGCACTGTCTATTCTATCACCCTGTTTTGTTTTTGTCAAA
GCTCATATTAACATCAGTTATTAATTATCTTGTTTGCTCATAATTTTTTTTTTTTTTTTTTTGGAGACAG
AGTCTCGTTCTGTTGCTCAGGCTGGAGTGCAGTGGCACAATCTTGGCTCACTGTAACCTCCACCTCCCAG
GTTCAAGTGATTCTTGTGCCTCAGCCTCCCAAATAGCTAGGACTACAGGCACGTCCCACCATGCCCAGCT
AATTTTTGTATTTTTAGTGGAGACGGGGCTTTGTCATGTTGGCCAGGCTGATCTCAAATTCCTGACCTCA
AGTGATCTGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCGGCCTGCTC
ATGAATTTTCTCTTTAACTTCCACATCGAAGGCAAAGTATTGTCTTGTTAAGGCTGTGCCTCCAGCACCC
AGCACAGGCTGGGCGCACATTCCCTTGATGAACCTGATTTGTAATGCCTGTCGCCTCTTCCCTCGTTTCT
TCTAGGACCTGGCAATGCCCAGACATCTGTGTCCCCCTCAAAAGTCATCCTGCCCCGGGGAGGCTCCGTG
CTGGTGACATGCAGCACCTCCTGTGACCAGCCCAAGTTGTTGGGCATAGAGACCCCGTTGCCTAAAAAGG
AGTTGCTCCTGCCTGGGAACAACCGGAAGGTGTATGAACTGAGCAATGTGCAAGAAGATAGCCAACCAAT
GTGCTATTCAAACTGCCCTGATGGGCAGTCAACAGCTAAAACCTTCCTCACCGTGTACTGTGAGTAACTG
AGCCCGGAGGGCTGGACTAGGCAGACCCGGTGGGAGAGACGTGCAGGGGCACCTGCAGAGGCCTGGGGGA
ATCTTTGCCACTTGCTCGTAGGGTCAAGGAGGGGCTCCTTGCAGGGCAGGTGGGGACATCCTTGGAAAGT
CCCTTTGTGAATTTCTTTGGGTACAATTAAAGTATTTACAGGCTGGGTGCGGTGGCTCATGCCTGTAATC
CCAGCACTTTGAGAGGCTGAGGCTGGCGGATCACCTGAGATCAGGAGTTTAAGTTTCGCCAACATGGCGA
AACCCTGTCTCTGCTGAAAATACAAAAATCAGCCGGGCATGGTGTCAAGCGCCTGTAATCCCAGCTACTT
GGAAGGCTGAGGCAGGAGAACGCTTGAACCTGAGAGGCAGAGATTGCAGTGAGCCGCGATCGTGCCAGTG
CACTCCAGTCTGGATAACAGAGCAAGATTCCATCTCAAGAAAAAAAAAATGCCATCTCTCTATGCCTCAC
TCTTTGAACATATGACACGGTCCTGCTTCAGACACTTTAATAAAAGATGCAAATTAAGCCAAGTGTGGTG
GCTTGTACCTATAATCCCAACTACTCCAGAGGCTGAGGCAGAAGGATGGTTTGAGCCCAGGAGTTTGAGA
CCAGCCTGGGCAACAGAGTGAGACCCTGTTTCTTTCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCA
CTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACG
CCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCTGCCACCATGCCCGGCTCATTTTT
TTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTAGTGGTC
CGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACTGTGCCCATCCAAGACCCTGTTT
CTACCGGAAAAAAAAAGTAAATAATTTAGCTGGGCATCGTGGTGTGCACCTGTAATCCCAGCTGCTCCTG
AGGCTGTGATGGGAGGATTGCTTTAACCCAGGGGTTCGAATCCTAGGAGTTCGAATCCATCCTAGGCAAC
ATAGCAAAACCCCATTTTTATTTAAAAAAAAAAAAAAAGATATGAGTTAAAACTAGCCCTGGGATGGCAT
TTTTCACATATTGGTAACAAACAAAAGAATTGATGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCA
CTTTGGGAGGCCGAGGCGGGCGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAAC
CCCGTCTCTACTAAAACTACAAAAAATTAGCCGGGCATGGTGGCAGGCGCCTGTGGTCCCAGCTACTCAG
GAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGATCGTGCCACTGC
ACTCCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAGAATTGATAACAGCT
GTGCTGCCAAGGCTATTGGAACGTAGGAGGTCCTAGGACAGTGCTGTTGGGAGCATAAATAAGCCCAACC
CTGTGGCGGGAAATTGGGCATCAGTTCTCAAAATGTCATGGGCTGGGCACGGTGGCTCACGCCTGTAATC
CCAGCACTTTGGGAGGCTGAGGGAGGCGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGACCACCAT
GGAGAAACCCCGTCTCTATTAAAAATACAAAAAAAACTAGCCAGGCATAGTGGCACATACCTGTAATCCC
AGCTACTCGGGAGGCTGAGGCAGGAGAATCTCTTGAAACTGGGAGGCAGAGGTTGCGGTGAGCTGAGATT
GCGCCACTGCACTCCAGCTTGGGCAACAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGAAATAAA
AGAAGGTATGTTGAATATGAGTGGTATGCCACCCTCACATTAGGGAAGGGCAGTTTCGGGGAGGCTGTAT
TTATGTATAAAATAGCCCTAAAAGGAAGTGGGAGAAATGACAATATTAGCTGGCTATGAGAAGAGAGGCT
GGGAGGCTGTGGGAGAGGGCTTGGGTGTGGAGAATTCTTTTTGTTTTTTCCTTTTTTTGAGACAGAGTTT
CACTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTCACCGCAACCTTCACCTCCTGAGTTT
AAGTGATTCTCCGGCCTCAGCCTCCCGACTAGCTGGGATTACAGGCATGGGCCACTACGCCTGGCAAATT
TTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTTGGTCAGGCTGGTCTTGAACTCTGACCTCAGGTGAT
CCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAACGTGAGCCACTTTGCCTGGCTGAGAATTCTTTT
TTTGTTGTTGTCTTTTTGAGATGGAGTTTTGCTGTGTCCCCAGCCTGGAGTGCAATGGTGTAATCTCAGC
TCACTGCAACCTCTCCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGAATTACA
GGCGCCCAGCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGATTTCATCATGTTGGCCAGG
CTGGTCTTGATCTCCTGACCTTGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGA
GCCACTGCCCCCAGCCGAGAATTTCTCTTTGCGTCCTTCCTACTTTGGGGACTTCGAATGGTGGGAAAGA
GTTATCAAGGCCAAAATAAGGAATTCAAATGAAAACAAAACAAAATCAAAGAAGAAAAAACAGAAGAGCA
CTGGGCAGGCTAGGCACGTGGCTCATGCCTATAATCCCAGTGATTTAGAAGGCCGAAGTAGAAGGATCGC
TTGGAGGCCAGGAGTTGGACACCAGCCTGGGCAACATAGCAAGACCCCATATCTACAAAAAATAAAAAAC
CTAACCAAGCGTGCTGGCATACTAGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGGATCACCTGAGC
CTGGGAGGTCCAGGCTGTAGTGAGCCGTGATGACACCACTGCACTCCAGCCTGGGTGACAGAGAAAGACC
CTGTCTCTAAAAAATAAAAACTGGCCAAGTAGCTTTGGGATTAGCCTTGGGTTCCAGTCCCAGCAAGGCC
TTTAATAGCTTGGGACATGACTTCTGCATTTACTTTGCAATCAGGTGAGACCTCCTCTGATGGGGAAAAT
GACACGGTGAGTGACAAAGGATGTTCTCCTATCATTGTGTCAGGGCAAGGAAGCCTCTGGGTAAATGATC
AAATGATCAGCTTTGCTTCTGATTTGGAGGGTGGGTGAGCAGATGCTGACCTTCCCAGGTGAGGGAAGTC
CCCGAACATTCCCAGCAGCTTCTGGAAACCCCAGGGAAACCTCTTTGAAGGTCTTTTCTGCATCTCTGCC
TGATAGGTCTTTTTTTTTTTTTTTTTTTTTTTCTTTTTTTTGACACACAGTCTTGCTCTGTCGCCCAGGC
TGGATCACTGCAACCTCCATCTCCCGGGTTCAAGCAGTTCTCCTGCCTCATCCTCTCCAGTAGCTGGGAT
TACAGGCACCTGGCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCAAGTTGGC
CAGGCTGGTCTCGAACTCTAGACCTCTGGTGATCCACCCGCCTCAGCCTCCCGAAGTGCTGGGATTACAG
GCTTGAGCCACCACGCGCGGCTCTGCCTGATAGCTGAGAGCATAGAACTCCAGGTTTGAGACCTGGCTCT
GCCACATTTCTCCCTCTATGACTGTGGGTGCCCCACTTTGCCTTAGTTTTTACCTCTGTGAAATGGAGCA
GATGGCTGGCACAGGTAGCAAAGGAGTAAAAGTTATGTGGGAGGGTGGTACCTGAGAGAGACTCTAGCTT
GGTCTTGCCCCACCCCTGGTGTAAACATAAAGAAGCCTCCCTGGATGGCTCAATCTTCTCCAAAAAGGTT
AGAGGTGTAATTCCTAGAGGAGGCGACCACTAGCTGGGCTTTGAAGGATGTGTAGGAGTTCATAAGGACA
GGCATTCTGGGCAGGAGGAACAGCCTGGGCAAAAGTTGGGAGCAGGGAGAAATCTTGATGGAGGCAGGAG
GAGGAGGAGGTAGGTTGGTGTAGGCCAGGTGCAGTGGCTCACACCTGTAATCCCAGTGCTTTGGGAGGCC
AAAGCAAGAGGATTGTTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACATAGCGAGACCCTGTCTCTA
AGAAAAAATAAAAAAATTAGGGTACAGTGGCATATGCTTGTATTCTCAACTACTCTGGAGGCTCAAGTGG
GAGGATCACTTGAACCCAGGAATTTTTTTGTTTTTGTTTTTGTTTTTTTGAGATGGAGTCTCACTCTGTG
GCCCAGGCTGGAGTGCAGTGGTGCCATCTTGGCTCACTGCAGCCTCCTCCACCTCCTGGGTTCAACCGAT
TCTGCTGCCTGAGCCTCCCGAGTTGCTGGGATTAAGGTGCCCACCATCATGCCCAGCTAATTTTTTTGTA
TTTTTAGTAGAGATAGGGTTTACCATGTTAGCCAGGCTGGTCTTGAACGCCTGACCGCAAGAGATCCTCC
TGCCTCAGTTTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACTGAGCCTGGTCAAGCCCAGGAATTTGA
GGTTACAGTCAGCTATGATTGCACCACTGCATTCCAGCCCAGGTGACAGAGAGAGACACTGCCCCTAAAA
AAAAAAAAAAAATTGATTGATGGGAGGAAGGGTGAGGTTGGCAGAGCCTTGAATGCCAGGTGGAGGAGCT
GGGACTTTCCTTCTTGGGGTGATAGGGAGTCATGGAGGGTTTCTGAGCAGGCCAGGGATTAGATAGCTGA
AGGCTGGATTTACTGGAAGCCAATGAGCAGTTGGCTATGGTCCTTGTCCACGCGGCCCATGTTGTGGGCA
GTGACCGTATTCAAGAAGGGAAGGACAGACAAGTATTTGAATACTTCAGTGACCAGGATTTGGTAAAGGA
CTGCAGGTCAGGGTCAAGAAGAGGTGAGAGCAGGACAGACTTCCTCCCCGCTGCACCAGGCAGCTGAGCT
GGGTTTCCTCTAGGGGCTGAGGTTTGAGGGTACCTCAAGTTCTGCAAGAGTCTATAGGAGGTGGTAAGAG
AGAAGAGCTGGAGGTCAGAGTTTTCTTGACTATATATATATATATTTTTTTGTTTTTGTTTTTAACAGCT
TAACAGCTTTCTGTTTTATTTTTAGAGACAGGGTCTCAGGGTCTCACTTTGTCACCCAGGCTGGAGTGCA
GTGGTACAATCGTAGCTGACTGCAGCCTCAAACTCCCAGGCTCAAGAAATCCTCCTCCCACCCTTAGCCT
CCTGAGTAGCAGGGACTACAGGTGTGAGCCAGCAGGAAGCCCAGCTGGTTTTTTTTTTTTCTTTGGTGTT
TTTTGTTTGTTTGTTTGAGACCGGAGTTTCGCTCTTATTGCCCAGGCTGAAGTGCAATGGCAGGATCTTA
GCTCACCACAACCTCCGACCCCCAGGATCAAGCTATTCTCTTGCCTCAGCCACCTGAGTAGCTGGGATTA
CAGGCATGCGACACCACACAAGGCTAATTTTGTATTTTTAGTAAAGACAGGGTTTCTCCATGTTGGTCAG
GCTGGTCTCGAACTCCCAACCTCAGATGATCCACCTGCCTCGGCCTCCCAAAGTGCTGAGATTACAGGCA
TGAGCCACCGTGCCCGGCCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCGCCCAGG
CAGGAGTGCAGTGGTTCGATCTGGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACTCCATCCTCCTGCCT
TAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAG
AGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCCGCCTTGGCCT
CCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGTCTGGCCTGGCCAGGCTGGTCTTGAACTCCTGAC
TTCCGGTGATCCATCTGTTCTGGCCTCCCAAAGTGCTGGGATTACAGGCATAAGCCACCACGCCATGCCG
AAGCCCAGCTTGTTTTTAATTTTTTTTTTTTTTTTTGGAGAAATGAGGTCTTGCAATGTTGCCCAAGCTA
GCCTTGAACTCCTGGCCTCAAATGACCCCGCCTTGGCATCCCAAAGTACTGGGATTACAGATGTGAGCCA
CCATGCCCCAGCCTTGCTTTCTTGAGATACGATTTAGAATACCATAAGATTCATCCCTTTTAAGCACATA
ATTCAATGACTTCTGTACAAACAACCATGACTACAATCTAATTTTAAAATATTTCAATCACTCTAAAAAA
GAAACCTCCTGCTTATGTACAGCGACTCTGTCTACCTCTTAAGTGAATTCTCCTACCTTTAATAGCCCTA
TTTTACAGTTCAGGAAACTGAGGTTCAGAGAGACAAAGTCACTTACCCACAGCAAAGAAGCAAGGCTGGG
TATCAAATGCAGGACCCCCCCGGTCCTGATGCTTTTTTTTTTTTTTTTTTTTTCCTCTGAGAGAGACTCT
CACTCTGTCACTCAGTCTAGAGTACAGTGGCGCGATCTCAGTTCACTGCAATCTCTGCCTCCTGGGCTGA
AGTAATCCTTTCCTCACAAGTAAACCTCAGCCTCTCAAGTAGCTGGGACTACAGGCACACAACACCACGC
CTGGCTAATTTTTGTATTTTTAGGTAGAGACGGGGTTTCACTATATTGGCCAGGCTGGTCTTGAACTCCT
GACCTCAGGTGATCCGCCTGCCTCGGCCCCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCACACGCAG
CCTTTTTGTTATTAGACTCTGTCATTACTGACTTTTTTTTTTTTTTAATAGAAACAGGGTCTTTCTTTCC
CAGGCTAAAGTACAGTGGCATGATCACAGTTCACTATAGCCTTAAACTCCTGGGCTCAAGTGATCCTCCT
GCCTCAGCCTCCCAAGTAGCAGGGACTACAGGTGTGCACCACCACACCCAGTTAACCATTCATTCATTCA
TTCATTCATTTATTTTGAGATGGAGTCTCGCTCTGTCACCTAGGCTGGAGTGCAGTGGCACGATCTCAGC
TCACTGCAACCTCCACCTCCCAGGTTCAAGAGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGACTACA
GGCGTGCACCACCATGCCAGACTAATTTTTGTATTTTTAATAGAGACGGGGTTTCACTCTGTTGGTCAGG
CTTATCTCGAACTCCTGACTTCGTGGATCCACCCTCCTTGGCCTCCCAAAGTGCTGGGATTAAAGGCGTG
AGCCACCGCGCCCTGCCAACCTTTTTTTAATTTTTCTTAGAGATGGGGGTCTCCCTATGTTGCCCAGGCT
TGTCTTGAACTCCTGGCCTCAAGTGACCCTCTTGCCTTGGCCTCACAAAGTGCTAGGATTACAGCCTGAG
CCATCACACCTGGCCAACAGGTTTTTTTTTTTGTTTTGTTTTGTTTTTTAAAGAATGTCTAGGCCAGGCT
CATTTACTTTCACCTGTAATCCCAGCACTTTGGGAGGCCGGGGTGGGCAGATCACTTGAGGTCAGGAATT
CGAGACCAGCCTGGGCAACATGCTGAAACCCCGTTTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTG
ACACGTGCCTGTAATCCCAGCTACTCAGGAGGTTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGG
TTGCAGTGAGCCAAGATCATGCCATCACCCTCCAGCCTGGGCGACAGAAGGAGACTCAGTCTAAAAACTT
AATTAATTAATTAATTAAAAATAAAAATACAAAAATTAACCTGGTGTGGTGGTGTGTGCCTGTAATCTAA
GCTACTCAGGAGGCTGAGGCAGGAGAATCCCCTGAATCCCAGAGGCAGAGGTTGCAGTGAGCCAAGATCG
AGCCACTGTTTGCCCAGTCTAGTGCACTGGGCTGCTGAATTTATTTGACCAGACACCTAGCAATAGACTT
TGAAGTTCTTTTCCACTTTTCACTCTAAGATGCTGCTGTCATGAATAAGGAATATTTTGATCCCCTTCAC
AAACACTCGGGGCCCTCTTACCAGTTTTCACTGAAGATCTTGACATTCCTATCTGCTTAGGTGTCTGGGC
GTGTTTGGGGGAGATACTGAAGAGGTAGGGCTCCCAGGCAGGTGCAGTTCGTCTGTTAGGCAGGCAGCAA
GGTCCACTTCACCAGACACCCCCACCTCTGTTTTCCTGCAGGGACTCCAGAACGGGTGGAACTGGCACCC
CTCCCCTCTTGGCAGCCAGTGGGCAAGAACCTTACCCTACGCTGCCAGGTGGAGGGTGGGGCACCCCGGG
CCAACCTCACCGTGGTGCTGCTCCGTGGGGAGAAGGAGCTGAAACGGGAGCCAGCTGTGGGGGAGCCCGC
TGAGGTCACGACCACGGTGCTGGTGAGGAGAGATCACCATGGAGCCAATTTCTCGTGCCGCACTGAACTG
GACCTGCGGCCCCAAGGGCTGGAGCTGTTTGAGAACACCTCGGCCCCCTACCAGCTCCAGACCTTTGGTG
AGGATTGAAGAAGCCAGCAGGGAGAAGGTGGGGGTGGGGTATCCTGCAATGCGGTGCCTGTGGCCACAGG
ATCTTTTGAGATGGGTGTGGCCCCGGCTAAGGGGTGCATGTGTTCTAGGCGTATGTGACCTAGGCTGCTG
AGTGGCCCTGGAAGAGGATCTCGCAGGAGGGGGAATGAAATGCCCCAGAGAAGGGCTTCGGGACGTCCAT
CCCTGTCTGCTCACACCTTTCTTCTCTCCCTAGTCCTGCCAGCGACTCCCCCACAACTTGTCAGCCCCCG
GGTCCTAGAGGTGGACACGCAGGGGACCGTGGTCTGTTCCCTGGACGGGCTGTTCCCAGTCTCGGAGGCC
CAGGTCCACCTGGCACTGGGGGACCAGAGGTTGAACCCCACAGTCACCTATGGCAACGACTCCTTCTCGG
CCAAGGCCTCAGTCAGTGTGACCGCAGAGGACGAGGGCACCCAGCGGCTGACGTGTGCAGTAATACTGGG
GAACCAGAGCCAGGAGACACTGCAGACAGTGACCATCTACAGTAAGAAGGGGCAGGGGCGGAGTGGGGCT
TCTTGGGGGTGTGACCTGAACCCGGGGCGGGGCTCACTGTGTGCCTATTCCAGGCTTTCCGGCGCCCAAC
GTGATTCTGACGAAGCCAGAGGTCTCAGAAGGGACCGAGGTGACAGTGAAGTGTGAGGCCCACCCTAGAG
CCAAGGTGACGCTGAATGGGGTTCCAGCCCAGCCACTGGGCCCGAGGGCCCAGCTCCTGCTGAAGGCCAC
CCCAGAGGACAACGGGCGCAGCTTCTCCTGCTCTGCAACCCTGGAGGTGGCCGGCCAGCTTATACACAAG
AACCAGACCCGGGAGCTTCGTGTCCTGTGTGAGTGGGGCTGCTGGTCAATGGCCCCTATCCCCCAAGGCC
CAATCTCCCTGAAGGTCCCATAAGGTCTTGCCTCCAAGTCCTGCCCCCACCCACCTCCATGTCATCTCAT
CGTGTTTTTCCAGATGGCCCCCGACTGGACGAGAGGGATTGTCCGGGAAACTGGACGTGGCCAGAAAATT
CCCAGCAGACTCCAATGTGCCAGGCTTGGGGGAACCCATTGCCCGAGCTCAAGTGTCTAAAGGATGGCAC
TTTCCCACTGCCCATCGGGGAATCAGTGACTGTCACTCGAGATCTTGAGGGCACCTACCTCTGTCGGGCC
AGGAGCACTCAAGGGGAGGTCACCCGCAAGGTGACCGTGAATGTGCTCTGTGAGTGAGCCGGCGGGCAGA
GCTGGGTGGGGGCAGGGGCCATGGACCTAATGCAATCCTCACCGCCTGTTGTATCCTCCCCACAGCCCCC
CGGTATGAGATTGTCATCATCACTGTGGTAGCAGCCGCAGTCATAATGGGCACTGCAGGCCTCAGCACGT
ACCTCTATAACCGCCAGCGGAAGATCAAGAAATACAGACTACAACAGGCCCAAAAAGGGACCCCCATGAA
ACCGAACACACAAGCCACGCCTCCCTGAACCTATCCCGGGACAGGGCCTCTTCCTCGGCCTTCCCATATT
GGTGGCAGTGGTGCCACACTGAACAGAGTGGAAGACATATGCCATGCAGCTACACCTACCGGCCCTGGGA
CGCCGGAGGACAGGGCATTGTCCTCAGTCAGATACAACAGCATTTGGGGCCATGGTACCTGCACACCTAA
AACACTAGGCCACGCATCTGATCTGTAGTCACATGACTAAGCCAAGAGGAAGGAGCAAGACTCAAGACAT
GATTGATGGATGTTAAAGTCTAGCCTGATGAGAGGGGAAGTGGTGGGGGAGACATAGCCCCACCATGAGG
ACATACAACTGGGAAATACTGAAACTTGCTGCCTATTGGGTATGCTGAGGCCCCACAGACTTACAGAAGA
AGTGGCCCTCCATAGACATGTGTAGCATCAAAACACAAAGGCCCACACTTCCTGACGGATGCCAGCTTGG
GCACTGCTGTCTACTGACCCCAACCCTTGATGATATGTATTTATTCATTTGTTATTTTACCAGCTATTTA
TTGAGTGTCTTTTATGTAGGCTAAATGAACATAGGTCTCTGGCCTCACGGAGCTCCCAGTCCTAATCACA
TTCAAGGTCACCAGGTACAGTTGTACAGGTTGTACACTGCAGGAGAGTGCCTGGCAAAAAGATCAAATGG
GGCTGGGACTTCTCATTGGCCAACCTGCCTTTCCCCAGAAGGAGTGATTTTTCTATCGGCACAAAAGCAC
TATATGGACTGGTAATGGTTACAGGTTCAGAGATTACCCAGTGAGGCCTTATTCCTCCCTTCCCCCCAAA
ACTGACACCTTTGTTAGCCACCTCCCCACCCACATACATTTCTGCCAGTGTTCACAATGACACTCAGCGG
TCATGTCTGGACATGAGTGCCCAGGGAATATGCCCAAGCTATGCCTTGTCCTCTTGTCCTGTTTGCATTT
CACTGGGAGCTTGCACTATGCAGCTCCAGTTTCCTGCAGTGATCAGGGTCCTGCAAGCAGTGGGGAAGGG
GGCCAAGGTATTGGAGGACTCCCTCCCAGCTTTGGAAGCCTCATCCGCGTGTGTGTGTGTGTGTATGTGT
AGACAAGCTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCATGGTTCACTGCAGTCTTGACC
TTTTGGGCTCAAGTGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACCATAGGCTCACAACACCACAC
CTGGCAAATTTGATTTTTTTTTTTTTTCCAGAGACGGGGTCTCGCAACATTGCCCAGACTTCCTTTGTGT
TAGTTAATAAAGCTTTCTCAACTGCC
|
| Protein Name |
ICAM1_HUMAN |
| Length |
532 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-NOV-1988 |
| Definition |
RecName: Full=Intercellular adhesion molecule 1; Short=ICAM-1; AltName: Full=Major group rhinovirus receptor; AltName: CD_antigen=CD54; Flags: Precursor |
| Primary Accession |
P05362 |
| Accession Version |
P05362.2 |
| Other SeqIDs |
sp|P05362.2|ICAM1_HUMAN,gi|68067956 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Jul 4, 2008 this sequence version replaced gi:74708103, gi:124098.; [FUNCTION] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; [FUNCTION] (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; [FUNCTION] (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; [FUNCTION] (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}.; [SUBUNIT] Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:12526797, ECO:0000269|PubMed:15099525, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:23858057, ECO:0000305}.; [SUBUNIT] (Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; [SUBUNIT] (Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703). {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; [INTERACTION] P05362; Q99828: CIB1; NbExp=3; IntAct=EBI-1035358, EBI-372594; P05362; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-1035358, EBI-3867333; P05362; P20701: ITGAL; NbExp=3; IntAct=EBI-1035358, EBI-961214; P05362; Q14145: KEAP1; NbExp=3; IntAct=EBI-1035358, EBI-751001; P05362; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-1035358, EBI-10171774; P05362; Q9BRX2: PELO; NbExp=3; IntAct=EBI-1035358, EBI-1043580; P05362; Q9UHD9: UBQLN2; NbExp=5; IntAct=EBI-1035358, EBI-947187.; [SUBCELLULAR LOCATION] Membrane; Single-pass type I membrane protein.; [PTM] Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.; [POLYMORPHISM] Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIM:611162]. {ECO:0000269|PubMed:9259284}.; [SIMILARITY] Belongs to the immunoglobulin superfamily. ICAM family. {ECO:0000305}.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/ICAM1ID40909ch19p13.html'.; [WEB RESOURCE] Name=Wikipedia; Note=Intercellular adhesion molecule entry; URL='https://en.wikipedia.org/wiki/Intercellular_adhesion_molecule'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/icam1/'.; [WEB RESOURCE] Name=Virus Particle ExploreR db; Note=Icosahedral capsid structure; URL='https://viperdb.scripps.edu/Info_Page.php?VDB=1z7z'.; [WEB RESOURCE] Name=Functional Glycomics Gateway - Glycan Binding; Note=ICAM-1; URL='http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_261'. |
| Source Db |
UniProtKB: locus ICAM1_HUMAN, accession P05362;; class: standard.; extra accessions:B2R6M3,Q5NKV7,Q96B50; created: Nov 1, 1988.; sequence updated: Jun 21, 2005.; annotation updated: Oct 12, 2022.; xrefs: X06990.1, CAA30051.1, J03132.1, AAA52709.1, M24283.1, AAA52708.1, X59286.1, CAA41977.1, X59287.1, X59288.1, BT006854.1, AAP35500.1, AY225514.1, AAO30128.1, AK312636.1, BAG35520.1, CH471106.1, EAW84086.1, BC015969.2, AAH15969.1, X57151.1, CAA40441.1, AF340039.1, AAQ14902.1, A29849, NP_000192.2, 1D3E_I, 1D3I_I, 1D3L_A, 1IAM_A, 1IC1_A, 1IC1_B, 1MQ8_A, 1MQ8_C, 1P53_A, 1P53_B, 1Z7Z_I, 2OZ4_A, 3TCX_A, 3TCX_C, 3TCX_E, 3TCX_G, 3TCX_I, 3TCX_K, 3TCX_M, 3TCX_O, 3TCX_Q, 3TCX_S, 3TCX_U, 3TCX_W, 3TCX_Y, 3TCX_AA, 5MZA_B, 6EIT_4, 6S8U_B, 7BG7_B; xrefs (non-sequence databases): CCDS:CCDS12231.1, PDBsum:1D3E, PDBsum:1D3I, PDBsum:1D3L, PDBsum:1IAM, PDBsum:1IC1, PDBsum:1MQ8, PDBsum:1P53, PDBsum:1Z7Z, PDBsum:2OZ4, PDBsum:3TCX, PDBsum:5MZA, PDBsum:6EIT, PDBsum:6S8U, PDBsum:7BG7, AlphaFoldDB:P05362, SMR:P05362, BioGRID:109610, DIP:DIP-36658N, IntAct:P05362, MINT:P05362, STRING:9606.ENSP00000264832, BindingDB:P05362, ChEMBL:CHEMBL3070, DrugBank:DB08818, DrugBank:DB12598, DrugBank:DB00108, DrugCentral:P05362, TCDB:8.A.23.4.1, GlyConnect:1423, GlyGen:P05362, iPTMnet:P05362, PhosphoSitePlus:P05362, BioMuta:ICAM1, DMDM:68067956, CPTAC:CPTAC-219, CPTAC:CPTAC-220, CPTAC:non-CPTAC-2679, EPD:P05362, jPOST:P05362, MassIVE:P05362, MaxQB:P05362, PaxDb:P05362, PeptideAtlas:P05362, PRIDE:P05362, ProteomicsDB:51830, ABCD:P05362, Antibodypedia:795, CPTC:P05362, DNASU:3383, Ensembl:ENST00000264832.8, Ensembl:ENSP00000264832.2, Ensembl:ENSG00000090339.9, GeneID:3383, KEGG:hsa:3383, MANE-Select:ENST00000264832.8, UCSC:uc002mnq.3, CTD:3383, DisGeNET:3383, GeneCards:ICAM1, HGNC:5344, HPA:ENSG00000090339, MalaCards:ICAM1, MIM:147840, MIM:611162, neXtProt:NX_P05362, OpenTargets:ENSG00000090339, PharmGKB:PA29592, VEuPathDB:HostDB:ENSG00000090339, eggNOG:ENOG502RZRA, GeneTree:ENSGT00940000162311, HOGENOM:CLU_036160_1_1_1, InParanoid:P05362, OMA:NLTVYWF, OrthoDB:731140at2759, PhylomeDB:P05362, TreeFam:TF333745, PathwayCommons:P05362, Reactome:R-HSA-198933, Reactome:R-HSA-216083, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, Reactome:R-HSA-877300, SABIO-RK:P05362, SignaLink:P05362, SIGNOR:P05362, BioGRID-ORCS:3383, ChiTaRS:ICAM1, EvolutionaryTrace:P05362, GeneWiki:ICAM-1, GenomeRNAi:3383, Pharos:P05362, PRO:PR:P05362, Proteomes:UP000005640, RNAct:P05362, Bgee:ENSG00000090339, ExpressionAtlas:P05362, Genevisible:P05362, GO:0009986, GO:0062023, GO:0009897, GO:0070062, GO:0005615, GO:0005925, GO:0001772, GO:0005887, GO:0016020, GO:0045121, GO:0005886, GO:0005178, GO:0038023, GO:0004888, GO:0001618, GO:0044406, GO:0007155, GO:0033627, GO:1904646, GO:0071333, GO:1990830, GO:0061028, GO:0007157, GO:0007159, GO:0050900, GO:0022614, GO:2000352, GO:1902042, GO:0002693, GO:0070374, GO:0046813, GO:0001910, GO:1900027, GO:0002291, GO:0002457, GO:0072683, Gene3D:2.60.40.10, InterPro:IPR003988, InterPro:IPR013768, InterPro:IPR003987, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003599, Pfam:PF03921, PRINTS:PR01473, PRINTS:PR01472, SMART:SM00409, SUPFAM:SSF48726 |
| Sequence |
mapssprpalpallvllgalfpgpgnaqtsvspskvilprggsvlvtcstscdqpkllgietplpkkelllpgnnrkvyelsnvqedsqpmcysncpdgqstaktfltvywtpervelaplpswqpvgknltlrcqveggapranltvvllrgekelkrepavgepaevtttvlvrrdhhganfscrteldlrpqglelfentsapyqlqtfvlpatppqlvsprvlevdtqgtvvcsldglfpvseaqvhlalgdqrlnptvtygndsfsakasvsvtaedegtqrltcavilgnqsqetlqtvtiysfpapnviltkpevsegtevtvkceahprakvtlngvpaqplgpraqlllkatpedngrsfscsatlevagqlihknqtrelrvlygprlderdcpgnwtwpensqqtpmcqawgnplpelkclkdgtfplpigesvtvtrdlegtylcrarstqgevtrkvtvnvlspryeiviitvvaaavimgtaglstylynrqrkikkyrlqqaqkgtpmkpntqatpp |
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