VAEAG: Vaccine Adverse Events Associate with Gene

Record Information
Record ID	50
Pubmed ID	28855356
SNP
Gene ID	941
Protein ID	P33681
Vaccine Adverse Events	injection-site reaction, flu-like symptoms, fever, diarrhea
Vaccine	Poxviral TRICOM-Based Vaccine
Gene Name	CD80
Official Symbol	CD80 molecule [Homo sapiens (human)]
Aliases	B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Other Designations	T-lymphocyte activation antigen CD80; B-lymphocyte activation antigen B7; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CTLA-4 counter-receptor B7.1; activation B7-1 antigen; costimulatory factor CD80; costimulatory molecule variant IgV-CD80
Chromosome	3
Location	3q13.33
Annotation	Chromosome 3 NC_000003.12 (119524293..119559614, complement)
MIM	112203
DNA Sequence	>NC_000003.12:119524293-119559614 Homo sapiens chromosome 3, GRCh38.p14 Primary Assembly TTATTAAAGAAACGGTTCAACTTTGTTTCTTCCCTTAGTATTGCTGACAAAGTATCTGCTGTAGAATACA GGAATTACTTAGAATAGAAACATAGTCATCACAACTGTTACTAAATGGAAAAGAAAAGAATTATTGAGTT AAGTATTCCTGTCAATACGGGAAACACTGCTAGTACCTTATGTTGGTGTTAGACCTCTCTGCCCTACACT GAGAATATAGTTTTACACAGGAGCAAGGTTTGTGAAGCAGCATAGTGAGGTAGCTAAAGCCATGGGCTGG CTCTAAAGGCTTTAAATCCCAGCCATGTGGCTTAGCTGCCATGAGATGTGCATTTGAGAAATGTTGTCTT CTTTTGCTGTTCAACTCCAGATTTTCAGATGATAATGTGATTATCCCAGCTTAAGTTGCGTCCACTTCTG GTCTAGTGAATTGTGGAAGGCAGTTTTAGAGAAAGGAGTCATGAGTAACATGAACAGCAGTTGGCTATGT CTTTCCAGTTCTCTGCTGATGTCAGAAAGACCCAGAAATACCAAGGAGAAAAAGCCATCTTAGGGATCTA AGGAGGCCCTATGGAAAGTTACTACCTTAGACATTTGAAGATAGCTTACTGCTTAGTACATACACTGTAA ACAACGATCTCATTTTAAATGAGAACTTTCTCATAAATATTTTACAAATGAGGTCAAACTAGCATAAAGC CATTTAAAGAGATTATCAGTCCAATATGAACCAGTTAAGTCTTTGGACTATCCCTTTCCTCCTTGACTAC TGCTTTGACGTACCTAAATCATTCGTCTTACATGTCAGAGGAAATTAGTTTTGGATAGTTCTCCTTTCTG CTGTACCTCATGGGGGAGTGAGAGAGCAGCAATAGAGAACACAATGAAAAAAATGGAATACTGGGTAAAC ACCAATAATATTTCCATTAGTCTCCTAAAGATGTTCATGCCATACTTCCTATGCATTACATTGGGCTTTT GTAAACAGCAGCATAAAATCTTCTACTCTGACATTAGGAAATCAGATAGTCTCTGAAGTTGACCTGTTAT TGGACAAATTCTACTTCCAGCAGCACTTTGCCTGACATATATATGTATATACCAGTTAACAGGCCACAGT CAAACTGATAAAGGGAAAGAGCACCAGAGTTAGGAAATCTGGGTTCTGGCGCTGGCCTTTATAATTCGGG TCACCTCCCTGGGCCTCAGTGCCTTTGTCATTAATAACACTGGTATTCTCTAAAGTCCCTTCCAGAACTC AAGAATTCTGCATTTCAAAACACCTTGATCAAGGTCACCAGAGCTACTTCTGTGCCCACCATATTCCTCT AGACACTTCCTGCAAAGCAACTGAAGTGAAGAAGCACCTAAGAGCAGATACGTAAAGGGCAAGGTGGGGT AATCTTGTCCATCTGAGGAAGTTCCCAGAAGAGGTCAATTGCAAATGGAGGTGGGACCTGAGAAAACAAA GAAATGATTACATCAAACCCTATATTGGCAAAGGAGGAAAACATCTTAAATTTATTTATATATTAAATTA TACATATATAATTTTTAAATTATATATGTATATATGTATATATAATTTAATTATATATGTATATATATAT ATTTTAAATATAAGATCTTAATTTTAATCTCTTAATTTACATTTTAATCTCAAGATCAAGGGTATTCCCA GCTTGTACACAGTAACCTTGATAGCTGAAGAATATGAAGGGAAAGCTGAATTATGAGAGAACTTAAAACT ACTCTGGCAATTTTTGTCACATGAAATATCGATCAGGCAAATGTTTAGTTATTACCAGCTATTACCAAAC GACCAAATGCTTGATCAAGCCACTCTTCTATGTGTGGGGCTCTCAGGCATGGTTGCTTTTCTCAATAAAC CTACATACAGTCCAGTAAAGGATAGAAGGAAGATGTGGTACATGAAAATCAACCTATGCTGGTGGTATGA GATGTGCTATAGAGGTGGAACTGCTTGAGCTAGACAAGATGACCACAGAAGGCCTTGTGTAGAAGATTGG GTACACGGCTTCATTTTGAAGTATCAGCAGACTGAGCAGAAGACTTTTTAGATAGAAAGTCAAGAAAATT GTAGATAATGACAGAACTGAGCCAGAGCAACATCCTGGAAAAGACATTCTGAGGAGTGAGCAAGCATTCA GTGGAAATGAAAAAACAGGATAGGAAGTTGAGACACTGCCTTGGGGGAAAATATGTGTAGGCTGCCAGGT TGTAGGGAAAGGAGCCTGAACTTGATGTCCAGTTTGAATCTTGGTTTTATTCTTCATCTGTATGACCGTA CCTCAAGCAAATCTCTTAACCTCTGGGAGCCTCTGGTTTCTCTCCCATAACATGGAAATAGATCTTGCTC ATAGAGATTTTTATAAGACTAAGATGAAATAGTGTTTTTGCAAAACAACCTGTTGTATAAGCGTCAGGTA TTATTTTTCATTTTTCTTTATATTTCCCCCTCCTGCCCAGGACAATTCTTGCTTTCCTTTATTTTTAAAG ATAATTTTGTAGACTAATTCCTATACTGGTGTTACTCTAACCTTCACAAGTCAAAGCTGAACTGTTTAGG GAGGCTTATAACTACCTGGGACCTGATATCAGTCTCTTGGATTCTAATGTCCCATGTAAGTTTCTCTTGC ATGAAAATACCTGGGGATTTGTGACTCACTAAAGCTAGTGCTGTGTTAGGCTCTCTTAACAGGATGGACA TTCCAGACCCCAGATAATAATTATCTCATTGTATGTAGAGTCATTAAGACCAAATCTAAAGTCTTGGGTT CCGTTTACCCCATTCATGTGAGGCACTGGAAACCATGCCATGTGAGGAACAATTGACAGAACTCAAGGGT ATTTAGACTGAAGAGATCAGCTGGAATGTGGAAAGTTAAAAAGCTTTGAAGCTTTTTCTGTAGGCAGTGG GGTCTCTTCTGAGTTTTTGAGTGGGAAAATGACATGACAGAGTAATTCTTTGTGAAATTTGGCTCCATGA TTCGTCAGTAGGATGAGTCTGTTAGTAAGAGGCAGAGAAACCAATGAAAATGTTACCGTGTTAATACAAA GTGACCCCAACCCATGTCCATCAATACTGAGAGATAGAGGGAAAAATGAATGATCAGAATAAGAAGTTAC CACAGGAATATTCAAGATGAACTCAAATTAGTGTTTAATAGATAATGAATTGGCTGACAAGACAATTCAA GATGGCAGAATGGAAACATGGCAAAAGAAGAGGTTACATTAAGCAAATTGCATATGGGGAGAAAGGAGAG GGATGCCAGCCATCTTGTAACTGTTCAGCTTAATCTGAAAGAGGTTTTTAAGAAGGTGAGGTAGTGGGTA AAACAGCTTAAATTTGTTAAGGGAAGAATGCCTCATGATCCCCACGATCCATGTATCCCAGAAGAGATGA CGGAGGCTACCTTCAGATCTTTTCAGCCCCTTGCTTCTGCGGACACTGTTATACAGGGCGTACACTTTCC CTTCTCAATCTCTCATTCCTCCTTCTCTCTCTGCATCTTGGGGCAAAGCCTTGGAGACAAGAACAAACAA TAAAAATGATAAGTAAGTTTCCCTTGAATTGTGCCCATATGTTAATATTTACTTTAGCAAGGCTTCAGAC TGGCTTAGAACTGGAGCAGTTGTTCTTATACCAGGGGTGATTTACAATGCTCCCTCTTTACCTCTTTGCC AAGGGGACATTTGGCAATGCTTGGGGATATTTTTGATTGTCGCAACGGGCAAGGGGTGCTACTGGCATGT AGTGAGTAGAGGCTAAGGAAGCTGCTAAACATCCTACAGTGCACAGAACAGCACTCCAAAACAAAGAATT ATCTTGCCCAAAATGCCAATAATGTTGAGGATGAGAGCCCCTGAATTAAAGGGGTAACACTGGATAGTTG GTATTAGAAACATCCTTGAGCCCACCAGACCTCTTTATCCTACCCTTGGGATAAGTTGTTAACAGCACAT ACTCTCTAAAGAATTCACTGAGCTTTGGGTTTTTTTGGTGCTAAAGCCTGGGAAAATCAGCAGATGTTGA TCTTCCGATTTTATTTGATCAGTGTACATGATTTCTACTCAAAGAAGGGTTGGTACCCCTTCATAGTGAT TATGGCCTTATTTCGGACCATAGAACTAGCAGTTCCTCTTCATTTAATCATAGAGATTGAGGGCAGCATA TGTCTAACACCCAAAGTGTAAATTCATAGGGTAAAATATCTTAGAAATCTCTTCTTTCATCAGCCACTCC TGATCTTTCATCCAAAAATGTATTCTAAAGAACTGAGAAAATGGACATTTTCCAGACACCTATGTGTGTG GCACTCTACTAGGCACTGGAATTCCAAAGACAAGAAGTCCCAGCACTTTGGGAAGCCAAGGCAGGCGGAT CACGAGGTCAGGAGATCAAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAA AAAATTAGTCAGGCGTGGCAGCACGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCCGGATAATTGC TTGAACCTGGGAGGCGGAGGTGCAGTGAGCTGAGATCGGGGCATACACTCCAGCCTGGGTGGCAGAGTGA GACTCCATCTCAAAAAAAAAAAAGAACTAAGAATTGGTTTGTGTTTTGAGATGGAGTCTCACTCTGTCAC CCAGGCTGGAGTGCAATGGCATGATCTTGGCTCACTGCAGTCTCCGCCTCCTGGGTTCCTGGGTTCAAGC AATTCTCCTGCTTCAGCCTCCTGAGTAGCTAGGACTACAGGTGCACGCCACCATGCCTGGCTAATTTTTG TATTTTTAGTAGAGACAGAGTTTCACCATGTTGGCCAGGCCGGTCTCGAACTCCTGACCTTAAGTGATCC ACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCCCACCCAGCCCAAGAACTGAGAA TTGGTGAGATCACCTGTAGCCATGTAGTTTCTCAACTGTATTAGTGCATCTTGCCCTCCTCCAAGAAAAT GATTCTTGGCACCAAAATTTGTCAATTTGCCTTTTCTCTAACTCCAAATCAAAATTAGAATATCAGCAGG ATGGTGGCCATGGAAGTTGGAATTCACTAAGGAGTGTGTAACAACTCACCTGCCAAATCGACTAGCCCTT AAAAAAAAATTAGAATATCATTTAGCATCAGAAACGTTTTCAAATTAGTTAGCAAACCCCAGTCTCCAAA AATATATAAAGTCAGGGAAAAAATAAACAGACTAAACTAGAATGTGTCTTGAGGGCAGTGACTTCTTGTC ATTGTAATTCCAGTGCCTAGTAGAGTGCCACACACGTAGGAGGTGTCCGGAAAATGTCCAGTGAATGAAC AGAACTTGTTGAGACAAGTAAAGGAGATGCTCATGTTTCCATAGGCTTGCTGTAAACATGAGAAGCGAAT AGGCTAAAACCTCAGAGAGATGCCGAACCATGGTAATAAAGTTTGATCTTCCAGAATTGAGATCAGGATG ATGGTATGATAGTACTTACAGTAGGTCAGGCAGCATATCACAAAAATTCCATTTACTGAGATTAAGGTAA TGGCCCAGGATGGGAGCAGGTTATCAGGAAAATGCTCTTGCTTGGCTATGGAGGGAAAAGAATAATGTCA GCTGTAATGTATTTCCTACTGCCTGATACTCATTCTGTGCCTTTTCTATTGATGCAACTGTGGAGTATTC TTTGCCTGGTCAGCTCTCCAGTATGCAGCTGCTAGCATTTTTCTTGCATAATTCTTCAATCAGGCACATA CTTGTGGGCAACTAATAGTCAGATGTCACATATTAAAAGTGAAAAAGATACTTTGAATGTCTGCATTTAC TGAGTTAAGTTGACATAAGGAAGATTCTAAGGAAATCTTTTACAAGCCATCTTGCAGTATCTCACTTTTA TAGCTGATTATAACTATGTGTTACTACTAACTGGTTGATGTTGTGTTCTAGGTATACTTTATTTTTCCTT CTCTAGCTCTGTCGTGCCTTCTCCCTTTCTCCTACCATATTCTCTCTCAACACATACACATCACACACAC CCTTACCTCACAGTAGCTGCCCTAAAGCTACAGGAGCCACTTTGCATTCACTTTCGGATACAGGTTTTTC ACCCTCTAGCTACTGGAAACACAGAACAAGTCTGGCAAAGAACTAAGTGTGGATATGGCTTGGTATTAGG TGGGACCATCCTAGAAGAGAGCACTGAAGGTTATCAGCTGTAGTTTCAGTCCCACAGAGAGCACAAGAAG TACACAAGGAAATGAGGGTGGGGAGGAGAAAGGTGTTGGTGGATATGGTGCTGCGGGTCCATCCCTCCAG ATCAGGAGCAGCAGCTGCAGTATTTATTCTTCAGCTGCTTTGAGGAATCATTAGCAACATCTGGAAAAAC GGCAGGGACACAAATTATAGCAGCTCATTTTCTGGTTTCTCTGAAATGGCTTACAAATAAATGAATATTT ACTAACTTATTGTTTTTACTTTTTTTCTTCATGCTGAAGTTTTATTTAAAACATAAAAGAAATGTTCCCC CAAAATGCTAGTGAATAAAGCAAAAGGATACGACACAGTGCTCTCTCACTATGAGTTAGCCAGCCTATCC AAGTACAGGGTAATATACAGTACTCAATGCTGGTAGAATTTCACAGTAGTTTAGTGTTAAAGATTATCTG TGCCTAGATTATGAAGAGATTCTCAATGTGTGATGCTTAGTTCTGGGTTTACACCTTACTGGGCATGAAC AAGAGCCCCTGCTCCTTGGCCATAGCCAAATCCCTTGGGCCCAAAGTTCTTTGCATAGCACCATTACAAT AGATTTCACCTTCTTTTTCAGTCAGAGTTGTTGATTCAAGACTCTTCCCACACTTTGCACATCAGAAACA GTTTTTGTGCCAGGGCTTTCCAGCTCCAATTATCTTCTCGGCAGCATATACAGAATCCCCACATCTGGAA CATTTCTCAGCACCTCCATATTTCTGAGCAAATTTAGAAGCATTTGGATTTCTTGTAGGCCTGTGAGGCT GAACACTCTCTGGCTTGATGCCCAGCCTCTCGCCATGTTAAGCGTGCCAGCACCCTGGCCATAACCATAG CCTTTTGTCCCATATTTCTTTCCATAGTAGGATTTGCAGTAGATCTCTTCATTGTGAATTGCCACTGTTG TGCTATCTAAATTTTTCCTGCAAACCATTGAGTCGGAGGCAGGAGCATGCACCACAGGCGGAGCTAGCAA GGCTGGGCTGGAGAGAGGGTCCAGGGAGTCCAAGATCCCTGTTTTTACTTTTCTGATTACCAAACCCAGT GGTAAGTTTTATTTATTTATTTATTTATTTATTTAAGACGGACTTTCACTGTGTTTCCCAGGCCAGGCTG GAGTGCAGTGATGTGATCTCAGCTCACTGCAATCTCTGCCTCCCGAGTTCAAGGAATTCTCCTGCCTCAG CCTCCCGAGTAGCTGGGATTACAGGGGCGTGCCACCACACCCAGCTAATTTTTGTATTTTCAGTAGAGAT GGGGTTTCCCCATGTTGGCCAGACTGGTCTCGAACTCCTGACCTCAGGTGATTCTCCTGTCTTGGCCTCC CACAGTGCTGGGATTACAGGCATGAGCCACTGCGCCTGGCCTAGTTTTATTCTTTTGCTTATTGGACTTC TCATCAGCATTTAGCCAGTTGGAATCTTCTCCTTCTTGGACTTCTGTGACACCACATCCTTCTGTTTCTG TTTGTTGCACTCCGTTTTCTCTGAAGGCTTTTCTTCCTCTTCTTGTCCTCTAATTATTGTTGTTCCCATG GTTCTGTTTGTGGTCCCATTTTGCCCTTACTGGCCCCAGTCTTCCTGGGTAATATCCTCCACACCTGAGA TTTGAAATGCCATCTGAGGCTGGGCACAGTGGCTCACACCTGTAATTCTGGCACTTTGGGAGGCCAAGGT GGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCTGTCTCTACTAAA AGTACAAAAAATTATCGGTGGCGAGTACCAATCCCAGGTACTCAGGAGGCTGAAGCAAGAGAATTGCTTG AACCAGGGAGACAGAGGTTGCAATGAGCCAAGATTGCACTCCAGCCTGGGTGACAGAGTGAGAATCTATC TCAGAAAAAGACAAAGAAAAAAAAAAAAAAGAAGTGCCATCTGATTTCTAAATTTGTATATTGGATGGAT GCCAGCATCTCCACCTGATTAAAACTGAATTTACTACCTGCTTTCCAAATCATATCTACCAGCTGTATTC TCCCATTTCAGTGAATAACAATACCATTTAGTTACCCAAATAAGAGTGTGGTATTTTCTTTGTGCTCACT TCCCAGTAGGCTCCCATGTATTTTCTGTTCTATATTCAGAATATCTCTGGAACTTACTGCTTTTTCCCAA ATCTCTTGCAGCAACTGCCTTAGCTGAGATTTTTCTCATCTCCCACCTAGTAGCCTGCAAACCGGTCTCT TTGCCTCAGGTTTCCTAGGCTCTAATAACTCCTGCACATTGCTGTCACAGTAATCATTCTGAAACACCTA TTTAATCATAGTGTACCTACCACTTAAAGACAGGATAGTTGGTTTTTCTTTTTTCTCTAAAACACCAGAT TGAATGGAGACATCAAGTGATTACCAGAGTTGACCTCTACAGATTAGAATGACACAAAAAATAACAAGCC ATTGCTGTTATCCTGGGAGTCTAGAAGTTTCACAGGCTTCAGCTCATTCCTGGCTTCCACTCCACACCCA TCCACAAGCCTCATTCAACCTAGAGAGAGTATGTGTGTGAGGGAAAGAGGGAGGCCTCAGTAGCAGCAAG CCAGGTCTATTGTGACACCTGTTAGAAACCTGGTAACATCCCACAGGGGCAGACCCAGAATCCAAGGTAC AGAGCGGTGTGAGGGCATCTGCACATGTAGCTTATTAGATACCATGAGTATGACTCTCTCAGATGTATCT CCTTCCAGTTTATCAAGGGAAAACAAATTTGGTGAGACTACACTAAAAAGAATCATATGCGCAATCCGCT TAATTAATACATTTGGGCTTTTTTTTTTTTTCCAAATCAGTTATTTACTGATATGGTTTGGCTGTGTCCC CACCCAAATCTCATCTTGAATTATAACTCCCACAGTTGCCACATGTCATGGGAGGAACCCAGTGGGAGGT GACTGAATTATGGGGGCGAGTCTTTCCTGCACTGTCCTTGTGATAGTTAATGAGTCTCACGAGATCTGAT AGTTTAAAAACAGGAGTTTCCTTATAACAAGCTCTCTTTTTGGCTGCTGCCATCCACATAAGACATGACT TGCTCCTCCTTGCCTTCTGCCATGATTTGTGAGGCCTCCCCAGCCACGTGGAACTGTGAGTCTAATTAAA CCTCTTTATTTTGTAAGTTGCCCAGTCTCGGGTATGTCTTTATCAGCAGCATGAAAAGGGACTAATACAT TTTCACCTCAAAGCTTTACTCACCCTGACCTGTAACATTTCTATGTACTATACACTTAATGTATATTTGT TAGTGCAGTCAGCCCTTGACCTCCTATAAATGCATTATTTGCTTTTGAATCTTATTCTAAAGAATCCCCA CACAGTCCAATTAATGAGATTTGAGACATTTATACCCTAAAGCTCTCCAGCCACAAAGACAAAAACCTTA AGTTAGCAAACTATAGCACATGGGCCAAACCTGTCCTGCACCTGTTTTTAAAAATGAAATTTTGTGGCTG GGTGTAGTGGCTCACACCTGTAATCACAGCGCTTTGAGAGGCTGAGGCAGATGGATCACCTGAGATCAGG AGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCCACTAAGAAAATACATAAATTAGCCAGTT GTGGAGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGTTTGAACCTGGGAGG CAGAGGTTGCAGTGAGCCGAGACCACACCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCTGTCTC AAAAAAAAAAAAAAGAAAAAGAAAAAAAAAAGAAAAATTTTGTTGGAACATAGCCATGTCATTCATTTAT GTCTTGTCTGTGGCTGCTTTTGTGCTACAACCAGCAGAATTGAGTTGTTGCAACAGAGACTGTGACTGCA AAGCTTAAAATATTTACTATCTGGCTCTATTCAGAAAAAAATTTGCCAACCCCTGTCTTAGAATGTCACA TATATCCATATTCCAATATAAATAATGTCCAAATCAAAATGCAATCCAAGCTAGTATTACTGATTTAATA ATCAGTACTCTACTGTTTTCTGCCTTCAATCAGAATAATGTAAAATTGGTTAAATAATGCTATAACAAGA AAGTAAAAATAGAGACTTAATAAACTATATGATTGAAGCCTCATTTTAATAAAATTTTTACAACACATAA AAGATGACTGAGACTGGTAAGTTTGGAGTATCAATAGTCATGTCAAAGTTTGGTTTATATTTGAACTAAT TTTCCCAGGAAATTTTGTCTCATTGAGGAAAATAAAGAATCTGCTGTAGCCGGGCATGGTGGCTCATGCC TGTAATCTCCACACTTTGGGAGGCTGAGGCGGGCAGATCACCTAAGGTCGAGAGTTCAAGACCAGCCTGA CCAACGTGGTGAAACTCCATCTCTACTAAAAATACAAAAATTATCTGTGTGTGGTGGCTGGCACCTGTAG TCCCAGCTACACAGGAGGCTGAGACAGGAGAATTGCTTCAACCTGGGAGGCGGAGGTTACAGTGAGCCAA GATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAATCTG CTGTAACACTGAAAGATCTAGAGTAAATCATACACTAGCATGAATTACTAGACCATCTAAAATAAATTAT CCACTTCGCAACTACAAGTAAAGACATGAAGAATTAAGACATGCCATATAGTATATATTGTGCTATATAC TTATGTGCAACTGTATTATCAAACTCAGTGTTTTGTTTCTTACTATACAGTCACAAAACCTATCCTTGGG AGTGGGGCTAGGGGTAGGGAGAGAGACCTGTGGTCCTCTGTATGATCAGCCGTACAATTTAAACAAGTAT TAATATTTTGAGCATCTCAGTTCACCTTGTAAGCCATCTTAAGCCATTATAGGCCTAAGATGTATATATT CATATAAACCCATCGTTTTCATTGTATATTTTCAAATGATTTCACCTCTTGGGGAAAGAGAATTCTCTGA GTTTACTACCAGTAGGGTAAAATATTTGCTCCAAAATGACCTCTTTTCAGGCGTTGTCTTCAAGGAGTTT GTCACTCACCTTTCCCAGACTTGGTTCAGAATGAACCAGTAGTTCTTAAAAAGCACATTCGCCCACAAAA AAAAATTGTTTGGCACCATGGAACCGTGTGGGTGGCATGCCCTAAAAGAAAGCACCAAATCCCTAAGGGC AGTTCCAAAGGGCAAATTTTAATGCTTTCAATAATACTATTGTTACAAAAACTTTTTAAGATGAATGCTT GATGGATAATGGTTTTTAGTATATATAAATTTTAGAATATTTATTACAAGAAAATAAGGCCGGGTGCAGT GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGTTCGAGAC CAGCCTGACCAACATGGTGAAACCCCATCTCCACTAAAGATAGAAAAAATTAGCCGAGGGTGGTGGCTGG CGCCTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGAAGAATTGCTTGAACCTGGAAGGTGGAGGTTGCA GTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGGGCGAGACACTGTCTCAAAAAAATAAAT AAATAAATAAAAAGAAAATTAGTAACATTATCACACCTTGCACAGTGACTTTATTTTTTAAATTTATTTT TTAAATTATTTTATTTATTTCTTTTAGAGACAGGGTCTCACTCTGTTGCCCAGGCTGGAGTCTAGTGGCA TGATCATAGCTCACTGCAACTTTGAACACCTGGGCTCAAGTAAGCCACCCACCTTACCCTCCCAAGTACC TAGGACTACACATGTGTGTCACCAAGCCTGGCTAATTTTTTAAATGTTCTGTAGAGTCAGAGTCTCATGC TTCCCAGCTGGTCTTGAACTCCTGGGCTCAAGTGATCCTCCCACTTCAGCCTCCCAAAGTGCTGGGATTA CAGGCATGAGCCACTGTGCCCAGTCTCACAGTGACTTTAATAAGTCATAATAGCACATGTCATTTGTATA TCTAAAAACACTATAAAACACTATCAAAATAAATACGACAATTCTAAAATGTATCTGGCTGAGTTACAGT AATGTGCCATGTAACATTTTCAATGGCATTCTGCATATATGATGGTAGTCCCATAAAATTATAATACCGT ATTTTTACTGTACCTTTCCTATGTTTACATACGCTTAGATACACAAATACTTATTGTGTTACAACTGCCT ATGTGTTCAGTATGGTAACATGCTGTACAGGTGTGTAGCCTCAGAGCACTGGGCTGTACCATGTAGCCTA GGTGTGCAGTAGGCTGTACCATCTAGGTTTATGTAAATACACTCTGATGTTCAGACAATGACAGAATTGC CTAATGATGCATTTCTCAAAATGTATCCACATCATTAAATGACACGACTATATTGTCTTTTTAGATTCGA TATAGTAGAAACTCCCCAGAACAATGTCACTTACTTGTATTCCAGTTGAAGGTCTGATTCACTCTTAAAT GTCCATACTTGATGAGACACATGAAGCTGTGGTTGGTTGTCATATTGAAATCCAGTTTGCTGCTAACAGC ATAGAGCTCAGTTTCAGGATCTTGGGAAACTGTTGTGTTGATGGCATTTAATTCTTCTCCATTTTCCAAC CAGGAGAGGTGAGGCTCTGGAAAACCTCCAGAGGTTGAGCAAATTATCCTTCTAATATTAGAAGTTGGAA TTTCAAAGTCAGATATACTAGGTGTAGGGAAGTCAGCTAAAGAAAGAACAAGAATATATAATTACGTATA GTTACAAACCTATGTGTGTAGAGGTTTATTTTTAAATAATTTTCTAGCTTTAATAAGAATTGATAAAGGC CAGGTGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGAACACCTGAGGTCA GGAGTTTGAGACCAGCCTGGCTAACATGGCAAAACCCCATCTCTACCAAAAATACATAAATTAACCAGGC GTGGTGGCAGGCGCCTATAATCCCAGCTACTCGGGAGGCTAAGGCAAGAGAATGGCTTGAACCCAGAGGG TGGAGATTGCAGTTAGCCGAGATCGTACGACTTCACTCCAGCCTGGGCAAAAGAGCAAGGCTTCATCTCA AAAACAACAAAACAAAACAAGAATGATAAAATGAGATATAATTTGCAACTTCCCATTACTCATTAATAGT TATGTATAATCCAAAGACTAACTTTGATTTGAATTGGTTATATCAATTCTTTGCCACTTTTGATGGAGAT AGGAGGGCACTTATTACAGAAAGGAGAAGTAGGTTCGTGTGAATAAATGTTGCCAGAGTACTTGCAATTG TAAGAGATGAAGAGAAGAATAATAGACAACGTTTACTGAACTCTTGTTTGTTAGGTCTGGACCTTACCTC ATTTTGTCCTCACAGAAACCCTAGAGAGGTAGGTTGTAGATCTAAAAAGGTCAAAGATCAGTAATTTCAT ATGATTTAACCTAATATAATTTCCATTTTATAAGTAATCAAACTGAGGTTTAGAGAAATTATAACTAACC AGTAATGGCAGAATTCAAATCTGTCTGACACCAGAGCCTATCTTTTCTTGACCTTGCCTTTCTTTCTTTC CTTTCCCTTTCTTCTCTTCTCTTCTTTTCTTCCTGATGCTTGAAGTACGCAAGTGGCTTTCTTCTATGTT ATCTATTTATTTACTAAACTATAGCGAACGCCTGAAAACCCACCATCCAACTTGAGACCAAAAACACTGA CAGTAACTTAGGTAAATCTGCTGGTATGATGTCACCTATCCTGTCCCTCTCTTTCCCTTACCTAAGGTAA TCACTATCACTATCCTAAATTTGTGGTTAGCATTTCCTTGCTTTTTAAAAGGTCGTCTTTTACATGAGGG GCCTACCCCTTTGCTCTTGAGAATGGTTTCTCATGTCCTCCTTTCTGGCCTTATCCTTTGAACATTGACT CTTAAGTCTGTTACAGGTAAGGGCTCCATGAAGTTGTGTTTCCCTTTTCTTTCTGGCTACCTAAACTCAA TACATAAATAGAGAAGGCTTTGCCTAACATAGAACTTTCGTTGGAAAGGGTCTAGATGGGGAGAGAGAAA ACATAAATCTGGTCAAGGAGAGGAGATCTTGGAGAAAGGAAAATGCTGCCTAATTTACAAACCTGTGACC TGCCTTTTGAGGGGGCATTGTGTGCGTGTGAGTGGGGGGCAGGCATTGAACTATAGTCATGAGCTTTTGC TTCTACTGAGTCTCACCAACACCCCATACCCCAAAAAAACACCCATGACCAGTATTTTTTAATTTGCATA TTTATTTCTGGATGGGTTTTCCCCTCTTTATTCTGTCCTCATGAGACCATGGGCAAAGCTCTTTATTTTA GGTGAGAAGAAAAACTCTGAACCACATCAGTAATGTTTTCATTTGAAAATATCATTGAAATGTATTTGAA TAAATTTATTTGAATTCATTTGAATTTTTTAATTATTTTGATAGTAGACATGCTGTTTATTTATTTAATG TGCATATGGAAGCCTGAAAAATAGAAAGCTGTATAGACTGAGTTTAGTTGTTAATTGGTTTGGGAGTCTT CCATGCATAATTTATGACTTCTTGGTGTTCTATATATTTGTCCGAATTAATTACTGGGATGAAGCTATGC TAGCTTTCAAACAGGAGATGCCTTTCAGAAATTTGTATATTGTGCAGTTGCCAGACCAATTAAATACCTG GTTGAAATTAAAAAAAAAAAAAGTAGTCTTTTACTCAGAAAAACCTATATCCAAACTACAACATTGAGCC TATAACCTCATTCACCACACTTTATTGTTTTTCTTACTATTTTGATATGCCTTAAAGGGACAGGAAGGCC TTCCTAGCATTCCTCCAAGACCCTTGAGGCACTGTTTCATTTATATATTTGATCCCCATAAGATTCTGAA GTACAAAGTACAGGAAAATAAATGCAGAGAACATAGGAGAAAGATACCTAGCGGCTTCGTCACTTATTCT TACACATAAAGAGATTAGCTTCTTAGCATGAATGTAGGGATTCAATCTCCTCATAGAGTTAGCTTTCTTT TCAGAATTCTGAGCCCCACAGAGATGTCATGTAGCATATGGTCATCAAAAGCAGGTTTTAAAACCAGTTC TGCCTTGTGACCCTGGGTCAATAACTTACCCACCTTTAGTCTTAGTTTGCTCATCTATAAGATAGGGACA CTAATACCCAGGGTTGTAAGAATTAAATGACATCGTTCATAGAAATCACTTAGCACAGAGCCTGACACAC AGGAAACTAAATAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACCATCTTGGCTTACTGCAACC TCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGGAGCCCACCACTACCAT CTAATTTCTTGTATTTTTAATAGAGATGGGGTTTCACTGTGTTAGCCAGGATGGTCTCAGTCTCCTGACC TCGTGATCCACCAGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCAATG ATAGCTATATTTAAGTGGGTCTTGAATTTATCCTCTCTTAGGTAAGCCCCCTCATTTAAATCAGGTTGCC AGGCAAACACTTCCAGGAATGCCTTGTGGCACCTACAATAATGAGGATAAAGGGAAGCCATGACAAATGA TGATAATTGCCAGGAAAGAGGAAAAGTTGGATTTGGTTGGAGGTGAAGTTACCTTTTTTTTTTGTTTGTT TCAATGAACCCTGTCCCTAAATGAAGTTTGATATGTTCCTGAGCCACTTTTAGTTGGCATTGTTATTTCC CACTTATTAATTTATCCTATAAGATCGACTCATGACACAGGCAGCTGATATCTAGAATATTCTGTGTTTC TTATAACATCAATATGTTTTGTGTTATAACTAGGAATAATAAATCCAAAAACTCATATCCTAAATTATTA ATATGATTCATGTTCATTTCTGTGCTCTGCTTTTCTGGGAAATAAACTACAGGAATGCCACTCATACCAG GAACTGTATTAAAAATCTTTTCAAGGCCAGGTGTGCTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGG TCAAGGCAGGAGGATCGCTTGAGGTCAGGAGTTTGAGACCACCCTGGACAACATAGTGAAACCTTGTCTC TACTAAAAATAAAAAATTAGCCAGGCATGATGGCACATGCCTGTAGTCCCAGCTAGTTTGGAGGCTGAGA CAGGAGAATCGCTTGAACCCAGGAGGCAGAGGCTGCAGAGACCCGAGATCACGCCACTGCACTCTAGCCT GGGTGACAGAGTAAGAGACTCCATCTCAAAAAAAAAAAAAGTTTCAAAATCTTTCTTGGCTTAGAACAGC CTAAACTCCATCTCCCACCTTTTTTCTAAGGTGATCTGTTTAGGGTAACTACTCCTGAGGTCTTGTGAGA TTGTGAACAATCAAAGACGTTGTAAGACTGTAACCTTTGTATCTCATTTTAATTAGTTAACCCAATTTTT ACCACTCTTAATAGGAAAGGGTAGGAATGTCTTACAAGGAAAGGAATAGGTGCACATGTTTTAGGAGGAA AAATCCATTAACCTAGTTAAGCTGTTAACGAATGTAGCTAGTTCTCAAACATGCCAGTTAATGGAGGTTT TCATATGGCTATGCTGATATTATATTACCATTTTGCAATCTTAGACAAATATAGGGTAACCAACGTGTCC TATTTGCCTGAGACTTTCCCAGTTTTAGCACCAAAAATCTTGTGCCCCAAATAAACCCTTTGGTTCTGAG CAAAGAGGATACCTGGTCACTCTAGCCAAATGAGAGCTTAATTCCTTGCTTCTCAAATTGTGGTCCTCCA CAGCAGCACAGGCATCACCTGAGAGCTTGTTAGAGGTGCAGAATCTCAGATCCAAACCCCAGACCTACTG AACTTAAATCTGCATTTTTAACAAGACCCTCAAATGACTCATAGGCTTATAAGCATTTGAGAAACACTGC TTTGACTCAATTGGAAAATTCAGAATGCTTCTCAGCAAAATTAAGCGAGTGACCTTTTTGTCTTCCCTTT ACTGGATTTTGTCCACCCACACACCCTCGGTTCTGAGTACCCCAGAAATCTCACATTGTCCCCTTAGCTG TCCTTGGTCTCTTACGGTAATCTGCTAATAGGGCCTGCCCCCCTTGAAATGTTTCCTTTTCTCACTCTTG GATTTTCTTCTTTATCTTTCTATCCAAATTCACCTGACCTGAGTCTACTTCTCTCTCGGTAGTCCATTAG AGGACTACGTACCTAATGTAATTAACTAATACAGGCTAATATATTTGTGGTGCCACCCCCCACCCCCCAC CCCAGGAAACACATTTTCATTTTAACAGGGATCTTTTAGGAGGAAAATGGAGAAACTAGCAGGAATGGCT ATGATGATGAGAATTTCAGGAGTCAATGCAGGTGAAAATCGTGGAAGAGGTAGGCTTCTTAGTACCCCTC AAATCACATCACCATATAATAATTTATTCTATCCAAGAGCAGAGAAAACACTGAGTGAAGTTTAAGATAG TTCCATGTAACTTTGGCTTACTCCCCACAACTTTAGGTGTGATCTGGATGTCACAAGTAAAGATTCATAG CTAATGATTAAAACAAAGAACAGTAAGGAATTCACTACGGATCTGCTGAAGTTATCTATTATCAAGGTTA ATCATTATGTTTTATTAAGTAAGAAGTTTGGTTTTCACTAGAGGCTCAAGTCCCAGGGGAAAAAGAAATA TGTTCAAATTTCAACTGTGAGAAAATGGCTCAGGGATATAATTTCTCAAAAAGGGCTCTGGCTCCTTCAG TATCCTCTGTTATACTGTAATTAAAGTGAAACCCCCTTTGCAAAATTATGACTGAGACAGTGAAAGAGAT CTAACTTAACTGACTCCATCTTGCTTCTAACCTCCAAGCTATCTTTGTTCACTCCTGGGTGTAGGCTGAA CTAACTTTGGTAGAAACTTAGTTTATAGTTTATAGTTTAAACAAAGATGGTAACAGCCCTTTCCCAAAGC AGACCTCCTTCTTGCCTGGGGAGTAGATTGCCTTTGTAGGACTAACATTAGCCACAAGATTAGAAATTAT GGTTTAGGAGTCATAAAGCTGGATGCTATGAGATTCTGACCCTCCCTAAACTGCTCCTAAGATCAGTGCT TGAGCTATTTTGCAGCCCCTGCACTTGATGGATCAGCTGGCACCACCCAGATCAATAAACTGACTCATCT GATCTTGTGGCCCCCCAACCCAGTGCAAGAAGACAGCTTCAACTCCCTATGGTATCATCCCTGACCAATC AGCACTCCCAGCTCACTGGCTTCCCCCGACCCACCTAGTTATCCTTAAAAACTCTGCTCCCCAGATGCTT GGAGAGACTGATTTGAGTAATGATAAAACTCCGGTCTCCCGCACAGCCAGTTGTGCGTAAATTACTCTCT CTATTGCAATTCCCCTGTCTTGATGAATTGGCTCTATCTACGCAGCAGGCGAGGTAAACCTCTTGGGTGG TTACAAAAGCAAGGGTCCTTTCTTTCCGAGACCAGAAATGCTTGCCTTCCACAGTAGGTACATAAACAGG GCTTTGATTCATAAATTAGTTTTTTTCCTTGTGGCAGGAATTAATTATGCATCCAATTCTCTAACTTTTT TTTTTTTTTAAGACAGAGTCTCTACCAGTAGGGAAATGCTCACCCTCCTCTGTAGTCTACTTTTTTTTTT TTTGAAACAGTCTTTGCTCTGTCACCAAGGCTGGAGTGCAGTGGCACCATCTCTGCTCACTGCAACCTCC GCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCCAACACGTCCCTGGCTAATTTTTG TATTTTTAGTAGAGATGGGGTTTCACCATGTTGGGCAGGCTGGTCTCAAACTCCTGAGCTCAAGCCATCC ACCCACCTTGGCCTCCCAAAGTGCTGAGCCACCGCACCTGGCCCAATTCTCTAACATCTAATTTTTCAGG ACTGACTGCTAGATTAGAGCTTCAAATATGCAATAAGTAAATTATCACTTTGAAAATATTAGAATATAAT AGTAAGATAGCCATAGTAATAGACGTTCACATACTACCTGAAAAAGATTTATGCCTCCATTGTTCTTTTT TTTTTTTTTTTTTTGAGATGGAGTCTTGCTATGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTC ATTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGA ATGCGCCACCACATCTGGCTAGTTTTTGTATTTTTAGTAGGGACGGAGTTTCGCTATGTTGGCCAGGCTG GTCTTGAACTCATGACCTCAAGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGAGATTACAGGCATAAG CCACCATACCCAGCCCCGTTACCTTTTCAGCATACTTTCACAGGCATATATTGCTGGGTCAAGTGCAGTT AGTAGCAAGGCTACATCAAATCAAAGATGCCCCTTGGTGATTGAGAGGCTCTTTAGGTCATTATAGTGCC CCAGGATGATTGTCATGAACTTGGATTGTCAAAGAACAAGAAATGCACATTAACAGATATTTCCAGGACA TCTTTAGAAACCAGTTAGAGTTTATTGTACAACTAGAGACTTAACTCCAAGAAATGAAGTGAGATACATC CCTCTTTGGTAAAATTTTCACCTAAATCAATAGCCATGTGTCTTTAAGGGCATTAAGAATCTGCCGGCCT AGAGTAAAATCAGAAAATCCCACCAACCTTTGACTGATAACGTCACTTCAGCCAGGTGTTCCCGCTTGAA AGCGTCTTTTTCATACTTCAGAACAACACACTCGTATGTGCCCTCGTCAGATGGGCGCAGAGCCAGGATC ACAATGGAGAGGTTATTAGTGATATCAAAGATGGTCCGGTTCTTGTACTCGGGCCATATATTCATGTCCC CAGACATCATAGTCAGCACCATTTTCTTCTCCTTTTGCCAGTAGATGCGAGTTTGTGCCAGCTCTTCAAC AGAAACATTGTGACCACAGGACAGCGTTGCCACTTCTTTCACTTCCTTGGTCACGTGGATAACACCTATG GAGAGGCAAACAGAACAAGATTGTATATTTATTAAATACAGATTCCTGCATGGTCAGGAATCCAAAGTCG GCAGTAACAGAACTTAGGGTGTTGTGTCTAGTGACTAAGTATCAATCCAGTTTGATTTTTGGGGTCCCCA ATGCTTTTTTTCTCTTCATTTTTTAAAAATTGTGGTAAAAAACACAACAGGCTGGGCGTGGTGGCTCACG CCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCG GGCCAACATGGTGAAACTCTGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGCGGGTGTAGT AATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTAAGCT GAGATTGCACCCCAGCCTGGGCAACAAGAGCAAAACTCCATCTCCAAACAAACAAACAAACAAACAAACA CATAACATAAAATTTATCATCTTATTGATTTTTAAGTGTACAGTTCAGTAATGTTAAGTATATTCACATT GTTGTGAAACAGATCTCTAGAAATTTTCATTTTGCAAATCTGAAACTCTATGCCCATTAAACAACTCCCC TTTCCCCCTCTCCCCTCAGCCTCTGGCAATTGCCATTCTGTTTGTTTGTATGAATTTGGCTACTTTAAAT ATCTCATAGAAATAGAATCATACAGTAACAGCCTGTTTATGATTGGCTTATTTCACTTAGCATGATGCAC TCAAGGTTCATTCACGTTGTAGCATATGATAGGATTTCCTTCCTTTGGAATGGTAATGATATGATCATAA GGATAATGAATAATATTACACACACACCCCCCCCCACATTTTGTTTGCCCATTCATCTGTAGATGGACAT TTGGCTTGCTTCCCACCTCCTGGCTACTGTGCTGCTATGAACATGGGTGTGCAAATATCTCTTCAAGACC CTGCTTTCAATTCTTATGGATATATGGAATTTTGGGGTCATATGGTAGTTCTATTTTTAATTTTCTGAGG AACCTCAATAGTGTTTTCTATAGCAGTTGCACCCGCAATGCTTGTTAAAGGTTTTGGAAGTCACTATCTA GAAAAACTAAATGTGATTGCATAAAAAACAAATTTGGTTTTGAAAACAATGAAGACAAATCACTAAAATC AGACTCATGGACCAATCATTATAACATAACCTATCCCCTTCCTTTTTCTTGAGAATTTTCCAATGACATG CAAGATTTAGGAGCATATGAGCCTTCTCTCACAGCAGGCAATTTTTAGTCCTATTACTTCTTATTTGGTT TACCTAACACAATACCACCCCCAAGAGAAGTCAGTCCTGACTAAGGTTCTGGGTACAGTGGTGGTGGAGG AGGGCAAGGTGCTGTTGCCCACCTCTGTCTAGATAGCCTATATTGAATTACTCTTCATACTATTTCCTTT TTTTGCTTCCTCTGTGGTGGCTCTATGGAGGGGACAGGTGCTATGTCATTTAATCCCCCAACAACCCCAC AAGATATGTATTATTTTCCCCATTTTGCAGCTGAGACAACTGAGAGATTGAGAGGTTCAGGAAGTCTAGG ACAGGGCAGGTCAGCCTGAGATTCCAAGGGCCTATGATTCTGCAGTCATGACGAAGAATAAGGGAGGGAG ATGAGGTCAACTAAGAAGAAAAAAGAGGGCCATACTTTAAATAGGTAGGGAATATAATCAATCTTCATTA TTCATGAATTCTCACTTACAGAAGGCCTCCTTCTTGGATCTGTTGCCTGGTCACTTGATTAGGTAATTTT CAGCTACTACTGCCTTGAGAAATAAGGAAGAATTTCACTGTAAAGACCTAGTCTCTGATGCTCACTGCCT TTTCCCTTGCGTTTCTCCTACAGCCCCTCTCCCCACAATCACGTGATGCAACAACACACACACACACACA CACACACAGATATGCACATGTACACGCATTCATTTAAACTACAGAACTGCATTTAACCGTGGGAAAAATC TAAGAATAAATTTTATCCAGATTAAGTGAGCTAAAGACAATCCATTTCATGTGACTTCAGTGGCGTGGCA CAGGAATAAAACCTTCATCTGTCACCTTAATACACATCCTGATTCCTCCCCTTTTCACTTGAGTGACTTA GGATTTAAAGCTCTCAGGACTGCCTACTTCCCTACCTACCTTAAAGGCAACCATGACTAAGTGCACCCTG CTAACATCCTTGCCTAGAGGCTCCTGGTTGTTGGTATAGAAAGAACATGGGCTTTTTTCATTCAATAAAA TCCACAGTAGTTGTGTGACCTTAAGCAACTTACTTTACTTCTCTGAACCCCAGTCTTCACATTGGTTATT ATGAAGATTAAATGAGATAATTTATGGCAAGCACATACTGTAATTCAATGCCTAGACCCACACCAAATAT GAATCCCATTCTCCTTTCTCCAAGGGGGTGGGGAATTTACCAACCTCTAAGGCTTTTGATTTCGTCTTTG GACAATTTGACTGAGGAAGTTTTGCTTTGCTTTATGTTGAAGTCTGTTTCCCTCTAGCTTCTACATGCAT TACAAAACACATCTCATTCTTCTTATGTAACAAGACTTGCAGATATCTGAGGATACTTATATCCTCTCTC AGACAGTTCTGCAGGTTCCCATCTGCCCCTGTTCCTTATTGATGTACTGAAAGTGAGTACCCTCACTTTC CTCACTACACAGTTTGATTTGTGTGTATATTTTTTTGAGAGAGCGAAGTCACTAAATCTAGCATTCCAGA CATCCACTGTGTGATTGGCTCAGAGTAGAACCGGGTTGTCACTTCCTTTACCTAAATCTATGTTTGCAGC CTAAAGTTGAATTCAATATATTAGCAGCCACCTTACACCTTTGATATAACTATTGATATACTGACAAGCA AATTGCCTTATTTTTCCACCTATACATACCACTGTGTGCTGCTCCTACATCCAGTTCAACACCCCACCAA ATGGGTAAAGCTCTTCCAGTGACGTTATCTTTCAAGAGTTATCCAGAATCTTCCCCTTCCCTGAATCTCC ATAAGACGACACATCTTTCTTTCTTTTTTCTTTTTCTTTTTTTTTTTGAGACGGAGTCTTGTTCTTTTGC CCAGGCTGGAGTGAAGTGGCGCGATCTCAGCTCACTGCAACCTCCACCCCCAGGTTCAAGCAGTTCTCCT GCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCCGCCATCATGCCCAGCTAATTTTTGTATTTTTAG TAGAGACAGGGTTTCCACCATGTTTGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATCCTCCCACCT CAGCCTCCCAAAATGCTGGGATTACAAGTGTGAGCCACCACGCCTAGCATGATGAGACATCGTGAGCATT CAGAAATATGGAAAGGCACCTGCTTGTCTTATGTATATAGCCAGATGCCTATGGGCCAGGAGTTGGGGAC AGAGACAGGGATCCCTAGTGAGTGAGAAAGTCCACTGGTCCCCTGAGAAGACCTGAATATAAGTGCCAAC CATGGGTTAAACGATGTGCTCAGCCCCAGGGGATATGAAAGTCATAGTAAGGAATGTGAGATCTGGAAGG GACTTCCATGATCATTCATTCTCGTGGCCTTATCTTACAAATGAGGAAACTGAGCTGAGGAAAAGAAACT GCCCCAGTTTTACACATTTTTTTCTTTCTGGCCCAGGCTTTTAGGGCCATTCTTCTTGTTTACCGATTTC TTCAGTTTTAGGCCACAGTCAGTAAGTTAAGCCAACACTGTCCCCACCCACCCCAATCCAGCCCTACCAC TGAGCCCTTTTGCTATAAGAAACAGAGTCCCAGGCCGGGCATCATGGCTCAAGCCTGTAATCCCAGCACT TTGGGAGGCTGAGGTGGGCAGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGTCAACATGGTGAAACCC CATCTCTACTAAAAATACAAAAAAATTAGCCGGGCATGTTGGGACACACCTGTAATCCCAGCTACTTAGG AGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACTGCA CTCCAGCTTGGGTGACAGAGTGAGACTCCGTCTCAAAATAAATAAATAAATAAATAAATAAGAAACAGAG TCCCTTTCTTTCCAGGCCTGATTGATCCCATGGTTCCAGGCTGAAATGACTCCCATGCTTATACCTTTGG ACTATTTCTACCATCTTCAGGTACCCTAAATGGATCCTATATCCTGCCTTTATCTCTTTGGCTATCTGCA GTCCATGCCATACAATTACCCTCCAGCCTGGATTTGCTAAAAGAGTTTTTATTTAAAATATTCTGTTCAT TTCTCCATCCACATAGCCAAGAAATATCAGCATATCAATATCTAAACTAGTCTCTGTGTCAATAGCACCA AAATTCCTTAGCAGGCTGTATTTTCTGATTTTTGGTTTAGAAGGCATGGTCATTCTTCCTAGGCTCTTGT AGGACCTAAAAGCAGCATCCCTCTAAGGCCCCAGCGCCCCCTGCCCAGTGCTGTCGTACTGTGCCTTCTG GGCCCTGTATCCCCTGGAGCCACACAGATCCCCTTAGGGAGACCCATGTCTAGGGACTTCATTTCCAAGC CCTCTCTTTTCTTAGATAGCAGGATCATGGGGCACTAGCACCTTTCCATCTCACCAGCCATTCTCAGGCC TCTGTCAGACTGGATACGGCCCCACCACAGCACTGAACAAGAGAGTTTTGTGATGGTGGGTATTTGCATA GCAAAGTGAGGTAATGCAGAAAGGTCCAGGCACCTCTTCAGCAATTGTGTGGAATGTTGCCAGTCCCTGC TTTAGGGAATATAACTGAAAGAAAGGAAGAAATAAAAAGACATACTTGAAGGGAGCATATTTCAAAGTGA AGCTATATTAGCTAAAGATCAAATGACAACCCAGACACTCCTAGTGTTGCAAGGAAAGCAAAATGAGACG TAGAAGGAACATGGGCTATCCATCTCCATTGACTTGGATTCTAGTCCCAGCTCAGCCACTTGCTGTTTCA TCTGTTTCTTCATCTCTAAATAGGTATGACACCTACCCCTTGGGATCACTGGAAAATTCAGTTCAATTAA ATGATATAAATAAAAAGTCCCAAGGACATAGCAGGTCTTCTGTAAGAGTTTCCATTTTTCTTTCTCCCTC CTCCCACTGCCAACTCTTACCTTTCATTTCACTCAAGGGTTATGTCAGATATATAGCACTCTGGTCTTGC TATGGGCCAGACAGACAGCAACTCACTTGTCTGGGCCTCCCAATAATAGGGTCTTTCCCCACCGAACTAT TCATTCCCAGCCAAAAAGAATCCAATATTTCTCACTGATTTTGGTATGTGGTGATGTTAGCAAAAGTGAA AGCATAGCTGAAAGAGAGACTATCTAATTTTGGTGATGGCTTCTGAGGAGTTTTTGTCCAGCCTTCTGAG GAGAAGAGTGAAGAAGAACAGGACTAAAAAGAGGAACCCAAAATCTTCCGAACAATTTGGAAATTCACAC GGGAACCCAGTTTTCGGGATTCCACCACACAGAGACAGAAAACAGTCATTATAAATTTGCCCAAATTTAT ATCAGTTTTGTCTGTTTTAGGGACTCCATCACACACGGACAAAAAGCAGTTGAAACGGAAATGTCTCTAA CGATTTTGTCTGCTTCAGTGACTGGCGGGGAAAGTCAGCACCTGGAAATCTCAATATTACTGTCTCAAAC CTGGTTGAACTTCTGAGCTTGCTTTGCCATTTTTGAATGGGCATTGTAACACCTACCCAACCCAGTGGGT GCAAGGATTCAAAATGAGATACTGCTCATAAAAGTCCTCCACAGTACCTAGGACATTAGAGGGAGCCAGT GTCTTCCCCAGAGATCCACACAGTTCAGGTCCCACTTTGCTCACATCTACTCTCGTGGCCCCTTGTCAAA GAGGCCTTCCCTGACTCTCCTTGAACAGCGCCATCCTCCCTGCCCCCCTCCATCCTGCTACTCTTTAGTC TCTTTGCCTGATTTGTTTCTCTTCAGGCTTGTCTCCAGCTGATATATATTTTTACAACTGTGATGTATAT TTACAGGTATATGTGATACATAATTACGTATGGAGCTATGGAGCAGAGGCTTCCTCCTTTGTTCACTGCC ATATCTGCAGTGTCTAGAACAGGGCCTGGCCCATAGTAGGTGCTCAGTAAATACTTGCTGAATGCATGTC TAGGCATGAGGAAATGAGGTCTGGCTCCATCCACTGTGTATTAGAATCATAACCTTGAGCAAGCTGGGTA ACCTCTCTGGGCTTCAGGTTCCATCTCTGTAAAACAGTCATAATACTATTGCTATGATTTGAATGTGTCC CCTAAAGGTTTTGTGTTGGAAATTTAATTCCGGGTGCAACAGTGTTGAGAATTGGGACTGTTAAAAGGTG ATTAGGTCATGGAGACTCTGCCATCATGGATGGATTAATGCCATTTTTTTGGGAGTGGGTTCACTACAGC AGGAGTGGCTTCCTTATAAAGGATGGTTTTGGCCTCCTTCCTACTCTGCCTTGGGCGTGCTCTCCTGCCT TTCTATCCTCTGCCATGGGATGATGCAGCAAGAAGGTCCTCATCAGATGTGAGCCCCTTGACCTTGGACT TCCCAGCCTCCAGAACAGTAAGAAATAAATCTCTGTTCTTTCTAAATTACCCAATGTCAGGTATTCTGTT ATAGCAGCACAAACCAGACCGAGATAACTATCTTCCCTGCTTCACATAATTATCACAGCGATCACAGGAT ACCAGATGTAAAGTGCTTTCTTAACTTTAGAATGCTCTACAGATTTTAAATGGGGCTGTTCTTTCTCATG CACAACAGCCTGCTTTGCTGAACCACACCCCCATAGGACCAGCATCACCATGGTAACTGGCTGATTCTTG AACTGAGTTCAGTGCCCATAGCTGGCATGGGGAGCCCCTCCTGCACCTCTACCCAGCAGCAGTCAGAAAG GGCCAGAGGCTGTGAAAGGAGGCGGAGAGAAGGCAGAGATGGACGGCAACGCTGCTCGCCTTCTGGCGAA TGCATGGAAACTGCCCACCTGTAGGGCACAATAGGGACACTCAACACTGCTGGCCTCAGCCTCTGCCTCT CCTGACCCCTTGGCCACCCTCCTGCTCTGACCACTTCAACTCTGGACTGCTAGCCACACAGGAGAGGAAG CTATTTGCCAACAAGAGTAGAGACCAAGAATTTTAGACAAATAATGGACCTCTCGGCCGGGCGTGGTGGC TCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCAGGAGCTCGAAGATCATCCTGGCT AATACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAATAAATTAGCCAGGCGTGGTGGCGGGCTGA TTTTTGTGTGGAGGACTTTTACGAGCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTG AAGCCGGGAGGCGGAGCTTGCTGTGAGCCAGAGATTGTGCCACTGCACTCCAGCTTGGGCGACAGAGCAA GACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGGACCTCTCAAGGGCTCAATCTAGGCCAGGCAC CCGTAATCCCAGCACTTTGGGAGCTGGCCAAGGCGGGTGGATTGCTTGAGCCCAGGAAATCGAGACCAGC CTAGGCAACATAGCAAAAACCCCATCGCTACAAAAAGAAAAAATAGATCTCAATCTACAACAGAATATTA TTTCAGAATATTATTTGGCCGTAAAAGCGAATGGAGTACTAAGACATACGCAACATGGATGAACCTGAAA GACATAATGCTCAGTGAAAGAAAATAGTCACGAAACGCCACATATTGTAAGAAATGTCCAGAATATTCTT TCTTACCTGGATTCTGGAAAAAAAGGAAGAGAAAAGAAATGTCTAGAACAGGCAAATTCATAGAGACAGA GAGTAAATTAGTGGTTACGAGGAGATGGGGTACAGGGGAATGAGGAGTAGCTGCAAATAGGCGCAGGTTT CTTTCTGGGATGATGATTTCCATCATCATCCAGAACATTTCCTTCTGGAATTCGATAGTGATGGTGGTTT CACAACATTGCAAATATACTAAAACCCACTGAATTGTACACTTTATTTATTTATTTATTTATTTATTTAT TTATTTATTTATTTATTTATTTACTGAGGCAGAGTCTCGCTCTGTTGCCCATGCTGGAGTGCAGTGGCAT GATCTTGGCTCACAGCAACCCCCGCCTCCAGGGTTCAAAAGATTCTCCTGCCTCAGCCTCCTGAGTAGCT AGGATTAAAGGCACGGGCCACCTTGTGTGGTTAATTTTTGCATTTTTAGTAGAGACAGGGTTTTACCATG TTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCATCTCGGCCTCCCAAAATGCTGGGAT TGCAGGAGTGAGCCACCGTGCCTGGCTGAATTGTATACTTTAAAACGTTGAATTTTATGTCATTGCAAAT AAAACATGAAGGGAAAAGAAGAATCCATACTAGGAAGACCTGAGTCTTCCCCACCCTCTCCGTGCAGCCT GGAGGCCTGGAGGATGCAGTGGCCAGTCTGCAGTGCCCCTCCCAGGGAGTTCAACCTCAGCAGCCGTTAG AGAGGCTGCCCTCGCAGGGGTCTGGGAGCTGCATCACCACTGCTAGTGGAGAAGGGAGAGAAGCAGTTGA CACAACATCTTTTAACTCACCAAATGACGGGACATACATGATCTCCCTGGAAACACAAGTGTGCTTTTTA AATAAACATTTTCCCTGACTATGAAATAAACATTCTTAGAAAGAATGGAAGATATAGAAAAGCGTGAAAG TCACCTATTGTCTCACCACCTGGAGATTTTACCGTTCCTGGTTTGTGCACACTCTTCCAACAGGAGTGAC CCCCCTCTAAATGTTTGATTAGGTGAACTAGCACCGACAGGGCTGGTGTCAGCCCTGGGCTAGGTGCTAG CCACACAAAGGAGACAGGCAGAGCTGCCTCTGGCAGCCACAGGCTTGAGACCTGTGTCTCCTCGTGTTCA CACTGTTCCTGACTTTTCCCCCTGTTTAGACCCTGCTCATATACTCTGTACCATCTGATCCTTACTTTTT CTCTTTCTAAACAGTATTTATATCCTTAAAATGCACAGGGACTTGAACAGCTGTTGTCAGGGTGATGATG GCAACAATCACTGCTCATGGGACCCCTGGGCCAGCAGCATAGCGGTGTGTGTTGCAGGGAGAGGAGGATG TGTTCTGTGAATGGTGGCACTTTGGGGTATTCTCTTTTCTCCTAGCTCTGAGTTCTCAGACTATAAACTT ATAGGCAATGCTTTTCCTACATCTCTTGCCTCCTCCTACAGGAGGCCTTTCCCCTCTCCTTAGACCTGAC CCTCTCTTAAAGGACTCCAGCTCTGAAGGAAAAGCTGCCCACATTGGTCCCTCTGAGGGCTGCCCTGTTA GAGCCTCTGCCTTACTGCCACCAGTTGCTGGACTATAAAGTCAGGCGTTTCTGCCTCCATAGACAGTGCC TGCAGGCCTAGAGGGGGAGAGGAGCCTGGCTGGTTCCACCCTGTGCATGAAAGAGGAGTCCCTTCCCCTG GGCATCAGTGGCTGGGCAGGAGGAGAGGGGGAACACCTCTGCCATGGTGTGGCAGGAGAGGAAGGCCTAG TGTGGCAAATCTCTGCCCTGAATAAAGCCCTCTATAATCCTACTCCACTGTATTCACTGAATCTCACCTC CCACAGACCATGCACACTCACACCTACACTCCCGTTGAGCAGTCCTCACTAATTTTACATGGTACACACT CTCCAACCCATCAACTTCCTTCTGATCCAATTCTTTTCATTAAAGACATCATCAGTTACTGTAAGTTACT GAAATAACCTCCTAATAGGTTTTGCACAGTCACTGTGGCTGCCCTACAAGCCACTCTGTTCTTCAGTAAC ACTTTTTTCCTTTTAAAGTTATTTACACCTTTACTACTGAAACTCAAAGTGTATGGTGGAGCAGCATCAG CATCACCTAGGTGCTTCTTAGAAATGCAGAATCTCAGGCCCCATCCCAGACCCACCTAAGCAGAAACAGC ATTTAAAAAACTATATAGACTTTATTTTTTAGAGCTGCTTTAGGTTCATCGAAAAATTGAATGTAAAGTA ACCCCCTCCCCACATATTCACAGCTTCCGCCACTGTCTACATCCTGCGCCAGGGCAGTACACTTGTTACA ATCAATGAACCTACATTAACACATCATTACCACCCCAAATCTAGAGTTCACGATAGGGGTCACTCCTGGT ATTGCATATTCTATGGATTTGGGCAAATTTATAATGACTTATATCTATCATTACAGTATTATGCAAAATA GATTCACTTCTCTAAAAAATTCCCTGTGCTAGAAACTGCAATTTAGCAAAACCCCCAGGCTATTGGTATG TGTAAAGAGTGAACAGAGCTGGGGTAGACCACGCCACTCTCCTGGGTAAAGCCCTTCCAGCTTCCTGAAT AACATGCGGATTCATGATTATAACTCACAAGTGCTGCAGGGTCCGGTTCTTGCTCACTGGGCCAGTCCCT CCTCTGCTACTTCCCAGCTCACTGCCCCTTCTTGCTGGCAGAGGAAGACAGCACTTCCTCAGGCAGTGCC TGTGCCCTGCCTTCAAAGCACGTGGCTTTGTTTGTTGGCCACACTTTAACACATTCATTTGAGTGGCTAT TGGATTACTTTTCCTCTTTCCAATGATAGTAAATTTCACAAATGCAAGAGCCATGTCCCCAGGACCAAGA AAAGTCTCTTGGTTTTAGGAGATGCTCATGTTTGTTGAATTAATAAATGATTAAACAAAAGAATGAACAC CTGTGCCAGCCTCATCCTTACCTTTGTGCCTTTGTCCAGGCTGTTGCCCTGACCAGAATTCTCTCTCCAT CATCCATCTGCCTCTGTAAAGCCTGCCCTCCTTCCTGCAGCCCAGTCTGTTACCCACTTTCCCAGATCTT GGGCTCCTACAATCAGGGCAAAGCATTTCATTGCTCTTTGCTTGTTCTACATGGGTTAGCTTTGCATTTC CGCAACTAACATATGCAGACCTCTTTGAGTGCAGGAATCCTAGCCTCAACTTTTATGGCCCACCTGGCAC ACAGTAGGTGCTTCATTGACTCAGTCACAGCAGCAGTAAAACCAGGATGTAGCTAGAGAACAAGGTGCTT TCCTAAACATCTTTCTTTAGCTCAAAGATCTCTTTCCACTTACCTCTGACCCTAATTTTCCTTGTACAAT TTCTAAAGTCTGGGTTTTAATTTTTATTTTATGTCCTCTTTTACTTTTTTTATTGTTCTCCCTCTTTCTG TCTCTCCCCCTCCCTGCCCCCCTTATTTCTGGGAAGCCTGTACAAATTTCCTTCTATATATTTTAAACTC CTCTGTACTCCCCAGAAGACTAGTTTGGGAATGCTTCCCCAGCTCCCCAGAAGGAAATTGTAACTGTTGG AAATGTAATGTAACTGTCAAATATATAAAAAACCTGAGGTGTAAATTGTGAAATGTAGGCCATGTTTCTC TTGGTTCTGAAACAATGTAAAATAGCTCTGGACAGAAAATTTTAAATGACCACCATCGCAGTCAAGTAAT CTGTGGGCCCCCAACTCCTCTTCTCTTCCCTCTACCTCTCTCTCACACCTCTGATATTCTAGGCAGTACT TTATGTGAGAAGTTTTTAAGACAAGGACCCTTAATAGTCGGGTCTTTGCAGACTGGCAAATCATGCTGGA GCCCAAACTTCTTTGTTTTTGGGAAACTGGGAAGTATGCTGCTCACTAGAAAACAGATCTTTTGTTTTCT GACTTAAAAAAAAAAATCAGAACCATCCTGCCAGCAGGGACAAGCCTCACCCTTCTTGACAGTCCCAAAA GTTCAGCACTCTTAAGATCACCTGAGCAGGAACAAAAGCCTCTAGAAGTCAAATTATTACTTTCAGGACA TATATGTAATACCTATGTGGCAGATTAAAAATAACTAAAAACATAATTTTGTGTTAAATCTGATACCACT TAAAGTCAGATGCCAATGTTGAAAAAAGATCTCAGCATCCAAAGCAGAACAAATAAGATTAATGTATTAA GAGGAACTTAAGAAGGTTAAGAAGATGAATGTCATTAAGAGGAATTGTCCTCAACTACTCTCCCGCCTTC AGATTGGAAAGAAGATCACCATTGTTCAATTTTAGAAGCAGGACACTTTCGCTGAGCTGTATCATGAAAA CATAGTTTGGGACTAGACTCCGAGGCCAGTATCGGCACATCACAAAATGTAAATGAGCATCTAATATTCA TGGAAGAGACCATTATGAATCGGCTGTATGGTTTTGTTAAAATAACACTGTCCCTTCCACGCTTCCTTGA AGGCCTGGGTTCTTGAGTTAACTTGGTTGCTAACTTGCTGTGTGATGATAGGCAGGTCCTTTAACCTCTT TGGACCACAGTCTTCTAATCTTTAAAATCTTCTGAAAACACCCTGAAGGTTCCTTCCAGCTTATAGGATA ATAGAAGGGAGCAGCTCAGAGAACCCCATGTCCTTTCTCTTAACCCTGTAGCAGTTGACTCAGTTAAGTT CCTGAAAGTTGCTTACCTGAACAGAAGTGAGAAAGACCAGCCAGCACCAAGAGCTGAAAGAAATTGAGGT ATGGACACTTGGATGGTGATGTTCCCTGCCTCCGTGTGTGGCCCATGGCTTCAGATGCTTAGGGTCAAAA GTGAAAGCCAACAATTTGGACCCAAGTAAGACCAGGGCACTTCCCAGGTGCAAAACAGGCAGGGCTGATG ACAATCCAATTGCTCACGTAGAAGACCCTCCAGTGATGTTTACAAAACACACAGAGATTGGAGGGTGTTC CTGGGTCTCCAAAGGTTGTGGATTTAGTTTCACAGCCTGAAAAAGGAACAAATAAAAGTCATTCAGGAAG GAAGGTGTGCCTACTTTGAGTTGCAAAACTCTCGAGTTGCCTGCTAAAATTAATTGGAGAGCTTAACCTA AGCAACCTCTAAAGCAGGGCGTGACCCTGAGGAAAAGCGAATGGAAATTCTGTGAGGGGACCAGTTCCAA GAACCAACCACAGCCCTTCCATGAAAAGGCTTTCTACTTAATAGGTGGGGTGAAGATTTGGTTAGAAACA GGAGAGCTCTAAGGACCCTCCATATCTGTTAGCCAACCTGCAAAAGTTCAAATCCTCTTCTGAACATACC AAGAAACATAGAGCAGACAGTAAGGGTGTATTTTGTCCAAGGCAGGACCTAAGTTATGAAACAACTTCTT TCTTGACATATTAACATAAGAAAACAAGTATCTCAATTCTTTAAACCCTCTACTCAAATAATATATCATA AAGGGGTATGAGATCTCAATAACCAGAAAAGTCTATCCATAAAAAGGGAGGGAAAAAAAGACACTGCAGA CGTTACTTATCAAAATTATGTACTCCAGGGCCAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGG GAGGCTGAGGTGGGCGGATTACTTGAGGCCAGGAGTTCCAGACCAGCCTGGCCAACATGGCAAAACCCCA TTTCTACCAAAAATACAAAAATTAGCCAGGTGTGGTGGTGGGTGCCTGTAATCCCAGCCACTTGGGAGGC TGAGGCACGAGAATTGCTTGAATCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATGATTGCAACACTGCAC TCCAGCCTAGGCGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAATTATGTACTGTCATGTG AGGTGGCTAGGGATTAATTTTTCCAGTAAATATGTCAAAATTGAGAAATGAAAATAAACACTGTGCTCCA CTGTCACCCCTTCAGGCTGCTACCAGGACACAGCCCCGTGCTGCTCAGAGAATGCTTGAGTGTCCTCTTT GGAGACCACCCTAGAGCTAGAGTTCCAGCCACGCCATATTGTTTTATTAGCCATCATCCATTTTAGACAG GATTAGTTAAAAGAGACTTATTCACCAGAATTTGTTTTTCTTAAGATAGAATCTTGCTCTGTCACACAGG CTAGAGTGCAGTGGCGTGACCATAGCTCACCACAGTCTCAACCTCCCGAGCTCAAGCGATTTTCCCACTT TCACTAGAATTTTACTGGCTTGAGAAATTCAAATACGGCCCACAAAAACAATATTTGCTAGGATCTAGGA TATTTTAAAATAATGGGCCACAATTCTCACTATGATGCTCCAAATATGTCGGGAAGCCACAGCCTCCTGT GGGAATGAGACCCTAAGGGTTCCTTTGAGGGCAAGCCTGGATCCAGGAGGTGGTAGCAGAGGTATTGTTT GTTTAAAAAGCAGTGAGGTTGCTGGTAACTAGTTCTACCAAGCTATCCCATAGTAAGATAATAGTAAATG TACTTACTTGCTGAAGAAAAATTCCACTTTTTCTTTAAATCCTTTGATTTCAGGGTAAGACTCCACTTCT GAGATGTTCTCTTCTTACAGTCTATAAAGCAATGACAAATCACTTTTTCTTTGGGTAATCTTCAGAGAGG CGACATTTCCCCTTCTAACTTCTGTTACTTTACAGAGGGTTT
Protein Name	CD80_HUMAN
Length	288
Moltype	AA
Topology	linear
Division	PRI
Update Date	12-OCT-2022
Create Date	01-FEB-1994
Definition	RecName: Full=T-lymphocyte activation antigen CD80; AltName: Full=Activation B7-1 antigen; AltName: Full=BB1; AltName: Full=CTLA-4 counter-receptor B7.1; Short=B7; AltName: CD_antigen=CD80; Flags: Precursor
Primary Accession	P33681
Accession Version	P33681.1
Other SeqIDs	sp\|P33681.1\|CD80_HUMAN,gi\|461606
Organism	Homo sapiens
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Comment	On or before Sep 20, 2013 this sequence version replaced gi:74755310, gi:74755311, gi:420007.; [FUNCTION] Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. {ECO:0000269\|PubMed:10583602}.; [FUNCTION] (Microbial infection) Acts as a receptor for adenovirus subgroup B. {ECO:0000269\|PubMed:16920215}.; [SUBUNIT] Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement. {ECO:0000269\|PubMed:10583602, ECO:0000269\|PubMed:11279502}.; [SUBUNIT] (Microbial infection) Interacts with adenovirus subgroup B fiber proteins. {ECO:0000269\|PubMed:16920215}.; [SUBUNIT] (Microbial infection) Interacts with Orthopoxvirus OPG038/M2 protein, inhibiting the interaction with CTLA4/CD152. {ECO:0000269\|PubMed:30918073}.; [INTERACTION] P33681; Q9NZQ7: CD274; NbExp=11; IntAct=EBI-1031024, EBI-4314282; P33681; P16410: CTLA4; NbExp=7; IntAct=EBI-1031024, EBI-1030991; P33681; P08138: NGFR; NbExp=3; IntAct=EBI-1031024, EBI-1387782.; [SUBCELLULAR LOCATION] Membrane; Single-pass type I membrane protein.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P33681-1; Sequence=Displayed; Name=2; Synonyms=s1CD80; IsoId=P33681-2; Sequence=VSP_047700; Name=3; Synonyms=s2CD80; IsoId=P33681-3; Sequence=VSP_047698, VSP_047699.; [TISSUE SPECIFICITY] Expressed on activated B-cells, macrophages and dendritic cells.; [MISCELLANEOUS] [Isoform 2]: Soluble isoform. Expressed in unstimulated B-cells and monocytes, but not T-cells. {ECO:0000305}.; [MISCELLANEOUS] [Isoform 3]: Soluble isoform. Expressed in T-cells activated by ConA, non-activated monocytes and monocytes activated with IFN-c. {ECO:0000305}.
Source Db	UniProtKB: locus CD80_HUMAN, accession P33681;; class: standard.; extra accessions:Q5DTA9,Q5DTB0; created: Feb 1, 1994.; sequence updated: Feb 1, 1994.; annotation updated: Oct 12, 2022.; xrefs: M27533.1, AAA36045.1, M83077.1, AAA58390.1, M83072.1, M83073.1, M83074.1, AY197777.1, AAO39208.1, AY197778.1, AAO39209.1, AC073352.22, BC042665.1, AAH42665.1, A45803, NP_005182.1, 1DR9_A, 1I8L_A, 1I8L_B, 7TPS_A, 7TPS_C; xrefs (non-sequence databases): CCDS:CCDS2989.1, PDBsum:1DR9, PDBsum:1I8L, PDBsum:7TPS, AlphaFoldDB:P33681, SMR:P33681, BioGRID:107379, DIP:DIP-6044N, IntAct:P33681, STRING:9606.ENSP00000264246, ChEMBL:CHEMBL2364157, DrugBank:DB01281, DrugBank:DB06681, DrugBank:DB04901, DrugCentral:P33681, GuidetoPHARMACOLOGY:2744, GlyGen:P33681, iPTMnet:P33681, PhosphoSitePlus:P33681, BioMuta:CD80, DMDM:461606, MassIVE:P33681, PaxDb:P33681, PeptideAtlas:P33681, PRIDE:P33681, ProteomicsDB:54922, ProteomicsDB:62752, ProteomicsDB:62753, ABCD:P33681, Antibodypedia:16574, DNASU:941, Ensembl:ENST00000264246.8, Ensembl:ENSP00000264246.3, Ensembl:ENSG00000121594.12, Ensembl:ENST00000383669.3, Ensembl:ENSP00000373165.3, Ensembl:ENST00000478182.5, Ensembl:ENSP00000418364.1, GeneID:941, KEGG:hsa:941, MANE-Select:ENST00000264246.8, UCSC:uc003ecq.4, CTD:941, DisGeNET:941, GeneCards:CD80, HGNC:1700, HPA:ENSG00000121594, MIM:112203, neXtProt:NX_P33681, OpenTargets:ENSG00000121594, PharmGKB:PA26239, VEuPathDB:HostDB:ENSG00000121594, eggNOG:ENOG502S5B5, GeneTree:ENSGT00940000162632, HOGENOM:CLU_071073_2_0_1, InParanoid:P33681, OMA:YLPRHVC, PhylomeDB:P33681, TreeFam:TF351094, PathwayCommons:P33681, Reactome:R-HSA-1257604, Reactome:R-HSA-2219530, Reactome:R-HSA-389356, Reactome:R-HSA-389357, Reactome:R-HSA-389359, Reactome:R-HSA-389513, Reactome:R-HSA-6783783, Reactome:R-HSA-6811558, SignaLink:P33681, SIGNOR:P33681, BioGRID-ORCS:941, ChiTaRS:CD80, EvolutionaryTrace:P33681, GeneWiki:CD80, GenomeRNAi:941, Pharos:P33681, PRO:PR:P33681, Proteomes:UP000005640, RNAct:P33681, Bgee:ENSG00000121594, ExpressionAtlas:P33681, Genevisible:P33681, GO:0009986, GO:0009897, GO:0016021, GO:0005886, GO:0098636, GO:0015026, GO:0001618, GO:0007166, GO:0071222, GO:0006955, GO:0035556, GO:0042130, GO:0045893, GO:0032725, GO:0032743, GO:0050731, GO:0009967, GO:0042102, GO:0045627, GO:0031295, CDD:cd16083, CDD:cd16086, Gene3D:2.60.40.10, InterPro:IPR013162, InterPro:IPR037676, InterPro:IPR042711, InterPro:IPR007110, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003599, InterPro:IPR013106, Pfam:PF08205, Pfam:PF07686, SMART:SM00409, SUPFAM:SSF48726, PROSITE:PS50835
Sequence	mghtrrqgtspskcpylnffqllvlaglshfcsgvihvtkevkevatlscghnvsveelaqtriywqkekkmvltmmsgdmniwpeyknrtifditnnlsivilalrpsdegtyecvvlkyekdafkrehlaevtlsvkadfptpsisdfeiptsnirriicstsggfpephlswlengeelnainttvsqdpetelyavsskldfnmttnhsfmclikyghlrvnqtfnwnttkqehfpdnllpswaitlisvngifviccltycfaprcrerrrnerlrresvrpv