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Record Information
Record ID 5
Pubmed ID 32219501
SNP
Gene ID 84868
Protein ID Q8TDQ0
Vaccine Adverse Events injection site reactions and edema of the extremities
Vaccine cancer vaccines
Gene Name HAVCR2
Official Symbol hepatitis A virus cellular receptor 2 [Homo sapiens (human)]
Aliases CD366, HAVcr-2, KIM-3, SPTCL, TIM3, TIMD-3, TIMD3, Tim-3
Other Designations hepatitis A virus cellular receptor 2; T cell immunoglobulin mucin 3; T-cell immunoglobulin and mucin domain 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; kidney injury molecule-3
Chromosome 5
Location 5q33.3
Annotation Chromosome 5 NC_000005.10 (157085832..157109044, complement)
MIM 606652
DNA Sequence >NC_000005.10:157085832-157109044 Homo sapiens chromosome 5, GRCh38.p14 Primary Assembly AACAGTAAAAAAAAATTTTTAGTAAGTTCCAATTGTGTGTCAGAATTGTGCTAGGCGCAGGGGGCAACAA TAAGCAAGACAGATCAAGCCTATACCGTCTTGAAATTTAAGTTTAGGGACCACTCTCTGTCAAAGGATCC AGCGCTGGTAATATAGATTGCTGAAGGCCTTTGCCTTCTTTCCACCAGGCAACAGAATTTGTGTCCCCGT CACTGCTTCTTCTTCTGTGAAAAATATAGCTTCAGTTTGGTCCACGAATACAGAAGTTGGTCAGAGATAT TTTCTTTCAAGCACACAACAAGCAAAACTTGGCCAATACACACCAATCAAATGCACTTCGTTTTTCCCTG GGAGCTCCTGCCACATCTCAGCCCTGCAGGGCAGTCTTCATAAGGGAGACAAAAGAAGGGCTATGCACTG GCACTGACAGTTGGGCAGGCAGTGCTCAAATAAGCCTAAATCTCAACATTCCAAGGGAATCTTCAAGATC AAGGTAGACCTGGTCCAGTCATCTCTTAATCTTTTAAGGATCACTGGCTGGATGTGGTGGCTCACGCCTG TAATCCCAGTGCTTTGGGAGGCCGAGGCAGGCAAATCATGAGGTCAGGAGTTTGAGACCACACTGGCCAA CATGGTGAAACCCTGTCTCTACTAAAAATACAACAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCC CAGCCACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGAT TGTGCCATTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAACAAAAAACAAAAAGGGATC ACAGATCTCTTTGAAAATCAGTGGCCCCTTTAGACTTTCTGTGCCAAAAAAGTTATGCTTTCACCTCAGC ACCCAGTTTTCCCTAGTTTATCTGAAGTTTCATGGACATATGATGTGCCCGAATTTCCTGGAGCTCCAGA GACCCCACGTCAAGAATTCCTAGTGTATATAAAAGCCCGTTTGAGCTCTAACATCCATGATTAACAGTCT CTGGGTTGGGTAACTCTGTTGGCTTAAATACAGAGGCAATGACATGCCTGTTTAAGTTCAGTGCAGGTCC CAGTTCAATTCCCATGTGAGTCATTATCTTCTGAAAATGGGAAAACTCTGCTCCATAGCAGTGGACAGAA CCTCCAAAACCAGTCAGGTGACACAGCTCATAGTTTCTGAAAAAGACAAAACACCAAGCTCAAAAATAAG GTGGTTGGATCTATGGCATTGCAAAGCGACAACCCAAAGGTTGTGAGGGTTGCTGCCTGCTGCTGACATA GCAATAATACTCATTGGGCTCCTCCACTTCATATACGTTCTCTTCAATGGTATAGATGTTTTCTTCTGAG CGAATTCCCTCTGCTACTGCATTTGCCAATCCTGAGGGAGGGAGGTTGGCCAAAGAGATGAGGCTGTGGA AATAAAGTGTTGCGGTTGAGTTAAGCATTTCCCAGGTAACACGGAATAGAGTTAAGAGAATAGGCTTTCC CAAAGAGACAGCAACTAAATATAGTGCATGATCTTTGATCAGATGCTGAACAAGTGGAAAAGCCAAGAAA TAGCAATAAAATACTATGGGGAAACAATTGAGAAAATGTCCATTAATTTTAATTTTCTTAGGTATAACAA CAGCATTGTGATAGCTAAGAGAATATTTTTATTTCTCGGAGGTGCAGGCTGAAGTTTAGGTGAAGTATCA AGATGTCTGCAATTATGTACACATTTAGATTTTCAAAAAATGGGCCGGGCGCCGTGGCTCACGCCTGTAA TCCCAGCACTTTGGGAGGCTGAGCCTGGCAGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACAT AGTGAAACCCCGTCTCTACTAAACATACAAAAAATTAGCCAGCGTGGTGGCATGCACCTGTAATCCCAGC TACTTGGGAGGCTAATGCAGAGAATCGCTTGAACCCGAGAAGCAGAGGTTATAGTGAGCCGAGGTTGTGC CACTGCACTCCAGCCTGGGTGACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAAAAAAATTATTAATGCT TTAGATAGCATTCAATGGACAGAGGTTTTTGTTTTGTTTTGTTTGATGCTGGGTCTTTCTCTGTCACCCA GGTGGGAATGCAGTGGCACAATCATGGCTCATTGCAGCCTTCATCTCCTGTGCTCCAGCAATCCTTCCAC CTAATGTTTCCATTTTTTTGTAGAGAAGAGGTCTCATCATGTTGCCCAGGCTGGTCTTGAACTCCTGGGC TCATGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGCTTATAGGCGTAAGCCACAGCACCTAGCCCA GAATCATTTTTGTAATCCAAATATATTGTATTCCATTCATGTGCCAAACATCACTAAAAGTCTAAAATCT AGTAAGTTATGTAAGCCATACCTATTTGAAATGGATGTGTGGGTGTGTATAATCAGGAACGAAGGTCAAG ACAGGAGTCTATAACAGACTAGCAGTTCTCAGCCCTGACTGTTCACTAGAATCACCTGGAGAGCTTTTAG AACAATTTCTATGCTTAGGCTTCATCCCCAGAGATTCTGATTCAGTTGCTCTGGGGTTGGCCCTGCATTA GTACACTTCAGTGCCTGGGTGATTCTAATAGGAAACTAAAGTTGAAAATGCCTGGGCTGTTTACAGAAAT GCTGAGAACAGATACTGGGTTTCTTGCTCACTTCTGTAACGCCTAAGTGCAGCCCAGACCCTGGATATAA TAGGAGCTCAATCCGTTGATGTTTCAGTTCAGTGGAAAAACCATTAATATCGAGATGAATAAGCATGTTG TATTATTAGGGTGATAAATTCTATACCTTAACTTTAGAACTAAAGAAGCTAGAGGTGTCAGGAAGTACAC ACAGTAGCATGTTACATTTTCACTTCATAACTAGACCTAGAGAAAGAAGGAAGTATAAACTCAGATCTCA AAGCCCCAGGACAGGATTTCTCAGAGAAAAGATCAGACATGTTAGAGTAGGGACTTCCAAGATTCTCACC TTTTCCCAACCCCATTCCATTATTCTTACCTTAAATTCTGTATCTTCTCTTTGCTATGAGAATACCCTAG TAAGGGGGAAACAAAAGCCAATAAAAATGCATTCATAAAATAAATGAGACAAGAAATCAAATAGGTTCAC TGGAAGCACGCATAGTTTAGGGAAATCTGGTCTCATCTCAGATTGAGTTAAATGAAACTCTCAACGTGTG CCTTAGATAGTTATATGGACTGTGTTAGAAAATAATAATAAAGATGCATTTTTCTTATTTAACAAATATT ATGAGACCTCTACTATGTGTCTGGCAGTTTGCCTGGCACAAGGAACACAGGAACATAAAAGTGAATTGTG AGCCCTAATTTCACGAAGCTCACGCTCTCCTGTGGGAGACCAAAGAAATAAAAGAAAACAGTACCCCAGA CCCAAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCTGGATGTGGT GGCCCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACATGAACCCGGGAGACGGAG GTTGCGGTGAGCCAAGATTGCGCCATTGCACTCCAGCCTGGGCAACGAGAGCGAAACTCCGTCTCAAAAA AAAAAAAACAACAACAAAAAGGAAATAGTAAATAGGAAAACAAAATAATTTCAAATTATGATGTATTATA AAGGAAACCAACATCATAGTGAAACAGATAATAGAGAGGGTGGTCAGGGAAGGACCCTCAGAGATGAACT TTAAGCTCGTTTCTGAAATGAGTCAGCCAAGTAAAGAGCCAGAAGGAGCATTCCAGGATGAGGGAGCCCC TTGTAAAGATCTTGCTGAGTACCTGAAACTGAAAACGTGGCTGGATTAAGGGAGCGGCCCAAGATAAGGT CTGAAAGGTAGGCTGGGGCTAGGTCCAATAAGACCTTTCCAGCCATAATCAGGAGTCTGGATTTTATTCT AAGACCTGTAGGAAACCTTAGATTTCCTTGAAGGGCAGAGATGTGATCCTTATTTGTTTTGGGTTTCTTT TACCCGCTGAAAACAACTACGTTATCTCATCATTTCTGTGTTGTGGGTCAGGAATCCAGGTGTGGCTTAC TGGGTACCTCTGGATCAAGGTCTTTCAAGGTGTCTTCTGGGGATGCAGTTTCAAAAATTTGAAACTTAAA ATTTTCCTTTCTTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTTGGC CAGGCTGGAATGCAGTAGTAAGATCATATCTGATTGCAACTTTGAACTCCTGGGCTCAAGGGATCTACCC ATCTCAGCTTCTGAGTAGCTAGAACTATAGGTGCACACTACCACAGCTGGATAATTTTTTTTAATGTTTT TGGGCTGGATGCAGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCAAGGCAGGTGGATTTCTTGAG CTTGGGAGTTCGAGACCAGCCTGGGCAACATGGTAAAACCTCATCTCTACTAAAAATACAAAAACTAGCC AGGTATGCTGGCACATGCCCGTGGTCCTAGCTACTTGGAGGCTGAGGCAGGAGAGTTGCTTGAACTCGGG AGGTAGAGGTTGCAGTGAGCCATGATCACACCACTGCACTCCAGCCTGGGTGAATCTCAATATGTTGCCC AGGCTAGTCTCAAACTCCTGGCCTCAAGTGACTCTCCTGTCTTGGCCTCCCGAAGTGTTAGGATTATAGG CATGAGCCATTGTGCTCAGACATTGATTTGGGTTTTAATATTGGATTCGAAGGAGGAATAAAGAAATGAG AAGATAAATTAAGTAGAAATAATGGTGTCTTGGAGTAAGGAATGGCCAAAAGAGATGCAGAATAATGAAA ACACTTTAGATGTATGTTGGAGGAAGACTGCAGGAATCTTCTGTTGTTGTTTTTCTCTGAGACAGGGTCT CCCTGTGCTGTGTCACCCAGGCTAGAATGCAGCAGCAAGATCATAGTTCATAGCCTCAAACTCCTGGGCT CAAGTGATCTTCCTGCTTCATTCTCCTGAGTAGCTGGGACGATAGGCGTGCACCACCATACCCAGCCCTA AGGAATCTCAACATCTAAGGATCAGGCAGAAGAAGATCTGAAAAGCAATGGATCAAAGAGAAGAATGTCA TTTCAGAAGCCAAGAGAAGGAGGACTTTCTAGAATGAGTGATCAATTTAAAAGGTTGACTATAATAAAGA TAAAGGTATCAGGCTGGGAACGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAG ATCATCTGAGGTCAAGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCCGTCTCTACTAAAAATAC AAAATTAGCCAGGCATGGCGGCACATGCATGAAATCCCAGCTACTCAGGAGGCTGAGGGGGGAGAATCAC TTGAACCCGGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCACCATTGCACTCCAGCCTAAGCAACAAGA GTGAAACTCTGTCTCAAAAAAAAAAAAAAAGATAAAGGTATCTGTTAATATTTAATTTAGAAAACTGAAG GTCAGTGGTGAGCTTGACCATTTCCGTTGTGCTTTGGAGCAGAAACTAGATGATGGTGGGTCAAGGAGTG TAGATGGGTGAAAAGTAGAGACAACTCCTTTGAAAAATATGGCTGTGAGAACGAGTTGAGAAATGGGACT AGCTGGAGAGGAATGCATGGACTAGAACATATATTCTGCTAATGAAAATAGCATAAACAGAAAAGGAGAG AGATGACTCAGAAGAAAGGGATAAAAAGAAGGATGAAGTCTTGGCCTAGGCAATGGAGATTAAAAAGCCC TTTCATATTTCATCAGTTAGGAGAGGGGCAAAGAAGTTTTGAGCAGCAGTGAGGTATGGATGGTCATCTC AGAGAGTACACTAGAAAGATGGAAGATTGTGGGGCATTATTGAGTGTCAGTTTGTTTTTGTGAGGTCATG ACTTAAAAAGCTGTCACCTTGATTTTAATATTTTCTCCAGCAACTTCCAGGGAAAAGATTGGAAATGAAA CAGGCCTTTCTTATCTGTACTTCTCAGTAGCCATGTTTTTTTGGAGTGGCATATATGTGTGTGTACAAAG CATCAGATTTCCTCTAGATCCCATCACTCTTTATACAAACTAGAATAAGTGCTAATATGTATAAATTATG GTCATATTATATATATATATATATATATATATACACACACACATATATATATAAAGTGGTCTCTAATATA TATAATAGTAAAGCTCAAAGTTTTACTTTGAGCCATGGCAGAAGTCAAAAAAGTAGTGAGTGTTATCAGT GCTCCTTAACAATCCCTAGTCTGTTTTGGAAATACTCAAGTGAGGCTAAGTGCAATGACTCATGCCTATA ATCCCAACATTTTGGGAGGCTGAGGTGGGAGGATTATTTAAGCCCAGGAGTTTGAGACCAGCTTGAGCAA CATAGCAAGATCTCATTTCTATTTTTATTTTATTTTATTTTATTTATTTTTTGAGATGGAGTTTCACTCT TGTTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGCTCAAGTGA TTCTCCCACCTCAGCTTCCCGAGTAGCTGGAATTATAGGCATGTGCCCCCATGCCCGGCTAATTTTGTAT TTTTAGTAGAGATGAGGTTTCTCCACGTTGGTCAGGCTGGTCTCAAACTCCCAGCCTCAGGTTATCCACT CACCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTAAGCCACCGTGCTCAGCCTCTATTTTTAAATATG TATATATTCATCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTAGGAGGATCACCTGAGCTCAGGA GATTGAGACCAATTTTCTGGGCAACATGGCAAAACCCTGTCTCTACCAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAACTAGCCAGGTGTGGTGGCATATGCCTGTAATCTCAGCTACTTGGGAGGCTGAG GCACAAGAATTGCTTGAACCCAGGAGGCAGAGGTTGAAGTGAGCCAAGATCACACCACTGTAGTCCAGCT CCCAGGTGACAGAGTAAGACTCTGTCCCAATAATAATAAATATATATATATATGTGTATACATATATATA CATATATATATATTCATGTGATCAATTCAAAAATTCCATGGCTATCTCTGAATAAACCCAGGTAAGTGTG GGTGGGGTAGTTTCTTTTTCTGAATAATCCATTTAACCATAATCGCAGAAACCATAAAGATGAGGAGCAG GACAGTCCTGGTTTCAAATCCAGTATCTATCAATTAACTGTGTAAATGCAGGCAAGTGACCTAACCTTTT AGCATGCTGATTCTCCATTAGAAACATATTAGTACCTATCTCATAGGGTAGTTACGAGAATTTAATGCAC GTAAAGCACTTGGCAGCTTCAGTCCACAGTTAGTGGGGGGACCAACTCATGTTTTTCTTGGACTGTTCCA GTTTTAGCCCTAGAAGTCCCATATATCTTAGGAACACCCTTTAGTCTTGAGCTAATCTGAGGTGATTGCT CACTCTACACACACAGTCCCTGTTTGTGTATTAGTAAGAAAGGCTGCTATGTCATATTACGCTCTGGGGC ATAAGGACTTGGTTTCTGCCCTAAAAGAAAATAAAATAGACACAATTATAAAAGTGTGTGAGTGGCCAGG CACAGTGGCTCACGCCTGTAATCCCAAAACATTGGGAGGTCGAGGTGGACGGATCACAAGGTCAGGAGAT CAAGAACATCTTGCCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGCGTGGTG GTACATGCCTGTAGTCCCAGCTACTCTGGAAGCTGAGTCAGGAGAAACACTTGAACCCGGGAGGCAGAGG TTACAGTGAGCTGAGATCGTGCCACTGCACTCCAGCGTCCATCTCCAAAAAAACAAAAGTGTGCGAGGTT TTGGGGGTACTGGAAGTATTTAGATCTTGATTGTGATGATGGCTTCCTACTGTAATTCTCCATCAAAATT CATCAACTTCAACACACTTCTTTTTTTTTTTTTTTTTGGAGACTGTCTTATTCTGTTGCCCAGGGTGGAG TGCAATGATGCAATCACCGCTCACTGCAGCCTCCTGAGCTCAAGTGATCCTCCCACCTCAGCCTCCTGAG TAGATGGGACTACAGGTGTGTGCCACCATGCCCAGCTCATTATTATTATTATTACGTTGTAGAGGCAGGA TCCTGCTTTGCTGCCCAGGCTGATCTTGGTCTCAAACTCCTGGGCTCAACTGATCCTCTCACCTCAGCTT CCGAAAGTGTTGAAAATACAGGCATGAGCCACTGCACCTGGCCATTGTATTTATTTATTTATTTATTTGC TTATTTATTTATATTTTATTACTTTTTTTTTTAAGACAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGT GGCATGATCTGAGCTCACTGTAACCTCCACCTACCAGGTTTGAGTGATTCCTCTGCCTCAGCCTCCTGAG TAGCTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTGTATTTTTAGTAGAGATGGGGTCTCAC CATGTTGGCCAAGCTGGTCTCGAACTCCTGACCTCAAATGATCCACCCCCCTCAGCCTCCCAAAGTGCTG GGATTACAGGCGTGAGCCACTGCGCCGGGCCTGTTTTTTTGTTTTTGTTTGTTTGCTAGTTTAAAAAAAA AAAAGGGATAAGTAACTTAGAAAAAGCTATGTGCTAAGTACCATGATGGAGGAAAACATTCTCTAACCCC AGTCACGACCCAGTGTTAAAGGGACTTGCAGTCTACTGCCAGAGAGGTATGCCTGAGAAACCAATAACAG AAAAGTGCACAGAAGGAAGTGTTTTTTGTTGTTGTGTTTCGTAACAAACCTAGACATATTCATGAATTAA AGAAATTAGTTTACTGGAATCAGCCTGCCTGGATTTGATTTCCGGTTCTGCCAGGTACTGATGTTGAAAC CTCGGGAAGGCAGCTTACTCTAAGCTTGACTTCCCTTCACTGTAAAATGGGGATGGTACTATTCCTTATC TCATAAGACAGTAATGATGATAAAATGTATGTAAAACATTTAACGCAGTGGCTGCCTGACACACAATAAA TATTAAATAAAAATTAGCCATTATTGTTAGGATTTGGATGGACAAAAGGGTATTTAGTCTAATCATCTTT GGGTATAAACATGAATTTGCATTTCTATCTAGGTTTTTACTGGTTCTCACTGAAGAATTTGTTATCAGAG GGAGAGAGAAACAAAAACACTTACATTTGAAAATTAAAGCGCCGAAGATAAGAGCCAGAGCCAGCCCAGC ACAGATCCCTGCTCCGATGTAGATGCCTATTCTGATGGTTGCTCCAGAGTCCCGTAAGTCATTGGCCAAT CTAGAGTCCCGTAACTCATTGGCCAATGTGGATATTTGCTATGGAAACACAAACAGGATTTAAGCAGAAA ACAGCTAGAAATCGCTTGTGTAATCAGCTTCAAGATTTGTGAATTGGACCATCCCTTTTACAACATCACA GGATGGCTGAGTCCTTCAAATCACCTTTGATCTGTCACCTTGTAGCCAACACTCAAGCCAACCCAAGAAA GGGTCTCCCTTAACCTTTGGAGTTAGCAAGGAAACAAAATGTGCCCTTCTGTGTTGTGGGTAGAGAAGGA GCTCTTAAAAAAAAAAAAAAAAAAAGAGAGAAGGAGCTCTTAAGACCCTTTCCCTGCCCCTGCAAAAATT GGCTTTAGAGTGGAGTCTTGTTGGTTCAAGATCCCCTAAGATTCCCCAGAGAGTTTTAGAGTAGTTTACA TTTAGTGTCTTGCTATGAAACGTCTATTTTTCACAAAAAGACAGTGATTCAATAGCCAAGACTTTACAGC CAGACGGTCGTGGATTCAAATCCCAGCTCTGAGGCCGGGCGCGGTGGCTAATGCCTGTAATCCCAGCACT TTGGGAGGCCTAGGCAGGCGGATCACCTGACATCAGGAGTTTGAGACCAGCCTGGACAACATGGTGAAAC CCCGTCTCTACTAAAAATACAAAACTTAGCCAGGCGTGGTAACACATGCCTGTAATCCTAGCTAGTGGGG AGGCTGAGGCAGGAGAATCACTTAAACCCAGGAGGCAAAGACTGGAGTACTCGAGTTGAGATCATGCCAC TGCACGCCAACCTGGGCAACAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAATTCCCAGCTC TGCCACTAAGGGCTGAGTAATCCTGTAGAGTTATCAGGAAAACTAAGTGAGAGAAAATATAAAATGCTTA GTACAGGGCCTGGTACATAATAAATGTTCAATCAATCGTAGCTATTATTGCTATTGCTCTAGTTAACTTG ATTTTCTGATAACTGAGAGCCACACAAAATAAATCCTGTTTCTAAAATTTCAGTCTATGGGTTCTCTCTT TTTCTCTCTTTAAAAACAATGATTAGGCCAGGTGCGGTGGCTCACGCCTGTAGTCCCAGCACTTTGGGAG GCCAAGGCAGGCAGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCT ACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCGGGCACCTATAGTCCCAGCTATTTGGGAGGCTGAGG CAGGACAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGGTTGTGCCATTGTACTCCAGCCT GGGCGACAAGAGCAAAACTCCATCTCAAAAATAAATAATAAATTAATAAATAAATAATAATTATAGGCCA GGCTCACACCTATAATCCCAGCACTTTGGGAAGCTGAGATGGGAGGATCACTTGAGACCAGGAGTTAGGG ACCAGCCTAATAATATTGAGACCCCATTTATACAAAACACACACACACACACACACACACACACACACAC ACATATAATTATAAGCATTTTTAAAACAATGAATTTAAGGAAGTTAAATCTTCCATTTATTCAATATACA TTTACAAATTGATTCAATACACATTACTCCTGCAATAACAGGAGTCCTATATGCAAGATATTGTGCATTA AGCATTGTGGGCACATACAGGTCCTTAAAAAGCACTGTTTGATTGCAAAGAGAGAAGGAGCAAATACAAG ATGCTGAGCATCAGTTGTGAATACACAAGCAAGAAACTGAGTCAAATAAATGTGGGCTCCTGGATATGCC CTCAAGTAATTTTTTTTTTTTTTTTTTTTTTGAGACAAGGCCTTGCCCTGTCACCTAGGATGGAGTGCAG GGGCATGATCACAGCTCAATGCAGCCTCAACCTACTGGGCTCAAGTGATCCTCCTGCCTCAGCCTCCCAA GTAGCTGGAACTACAGGTTTGCAGCACCATGCCTGGCCAAATTTTAAAAAATATTTTTTGTAGAGACAGG GTGTCACTATGTGGCCCAGGCTAGTCTCAAACTCCTGGTCTCAAGCATTCCTTCCACCTTGGCCTCCTAA AGTGCTGGGATTACAGGCATGAGACACTGTGCCCGGCCTCCTCAAAGAATTTTTAAGTCATTGCTGCAAG CTTGCCTTCTAGTGGTTTTTCTTTTATGAGGGAATTTCGCTCTTGTTGCCCAGGCTGGTGTGCAGTGGCG CGACCTCAGCTCACTGCAACCTCCACCTCCTGGATTCAAGCGATTCTCCTGTCTCAGCCTCCTGAGTAGC TGAGACTACACAGGCACACACCACCATACCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCAC CATGTTGACCAGGCTGGTCTCAAACCCCTGACAGGTGATCCACCCTACTTAGCCTCCCAAAGTGCTGGGA TTACAGACGTGAGTCACTGCGCCCAGCCAGTTTTTCTTTTATTCTGAGAAGGTAGCAGGGACAGTAAAAT TGAGGTTTATTAAGGTATGGCTTTATTTATAGTTAAATACATAAAACTGGCTGGGCACCATGGCTCATGC CTGTAATCCCAGCACTTTGGGAGGCCAAGTTGGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTG ACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGGCCAGGTGCCATGGCTCACGCCTGCA ATCTCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGATCAGCCTGGCCAA TGTGGTGAAACTCCGTCTCTACTAAAAATAAAAAAATTAGCCGGGTGTGGTGGCTCATGCCTGTAATCCC AGCTACTCGGAAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGAGGTGAGCCAGGATC ACACCCTTGCACTCCAGCCTGGGCAACAAGAGCGAAATTCTGTCTAAAAAAAAAAAAAAAAAACCTCTTC ACTTTGAATATTCCTGACTGGTGTCTTGCCATATTTAAAGAGATAAATTTAAATACTCTTTCCCATTAGG ATTGCAATGGAAGCAAGAAGAATGGTATTCTAGGGAGATGAAGAATCTTTGAACCTTCCACAGGGTAGAC AGTTGTGAAATTGAAGAATAAGAGGGACAAAATGCTAATGTTTCTTCTTTGTGGTTTTCAAGCTCTTACT ATATGCCAGGCACTTTACACACATCATGTCAGTCCTTCATTACAGCAGGCCTATGAGGTTAGAACTGTCA TCATCAACATGTTACAGCCCAGGAATCTGAAGCTAAGGGAACTTAAGGCTTTTTACCCCAAGGACAAGGT GGGCATGAAGGAAGTCTAAAGCCATGATTTCCCCTCCAAGTTGAGTACAACATAGCTCACAAAAAAAGTT ACTTACTGTTAGATTTATATCAGGGAGGCTCCCCAGTGTCTGTGTCTCTGCTATAAAAAGAGAGAGAGAG AGAGAGAGAGGAAAAATAGCCAATAGTATAGTTAAGAACGTTTTCTTTTATCTAAGTTTTTAAAAAATCT TAATGATGCCTATAATCCTATTTGAAATGAATTCTACTCCGTACTTGTCACAATAATTAATGGAGAGACA GACAAAATTTACTGAACACCCAGGAATCAACTTTAGGATGGCCACATTTTTTCATCTAGATAATGAACCG TACTGTTTTATGAAATAGAGACTTCTGCCAGGAAGTCCTACATTAAATATGTGCTTTGTTTTTTTCACAG GACCCTAATGAGTTCTACAAACATCTAGCAATATTGATAAGACTCAGGCATTATTTATTTATTTATTTAT TTAGACACAGAATTTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATAATCTCAGCTCACCGCAACCTC GGCCTCCCTGGTTCAAGCAATTCTCATCCCTCATCCTCCCAAGTAGCTGGGACTACATGCATGCACCACC ACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGAGGCCATGTTGACCAGGCTGGTTGTGAACTCCTGA CCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAATGCTGGGATTACAGGTGTGAACGACCAGGCTTGGCC TCAGGCATTATATTCTAATTAGATTTTAAAAGACAACAAAAATTCATTTCCTTCTTTTTTGTTTTTTTGA GACAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCAACTCACTGCAACCTCCATGTTC TTTTTCTTTTTTTTCTTTTTGCGAGACAGAATCTCACTCTATCACCCAGGCTGGAGTGCAGTAGCATGAT CTCTGCTCACTGCAACCTCCATCTCCTGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCCTGGTAGCTGGG ACTACAGGGGCACACCACCACACACAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTG GCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTAC AGGCGTGAGCCACCGTGCCGTGCCCAGCCTCCATTTTCTTAAATAAGTTTTGCATTTACTCATGAGAAGG GAGACAGGGTTGCCAACAAATGAAAATAATCACTGTGGTCACAATGTAATAGGAGCCAGGCCTTGTGCTA AATAAACTCTTTCAGTGAAGAAGCTCATTTTAGAGATACTTAGAAGCACTTACTTTAGAACTACGCTTCT AAAGTAGAGACTGTTAGTCCCATTGCACAGATGAAGAAACTGAAAATTAGGGAAGTGAAGTGACTAACCC AAGGTCACATGACTTAGCAAATGACAAAATGGCCTTCCAATTTAGGTCTGCATAGCCTTAAATGCACATT CTTAATTATACTGCCTTCACCAGCCCTTACCTCAGTGCTGTCATTATGAAGAGGGTCACGTTGCCCAGCC ACCCACTCACCATCTTTCCTTCCTGTTCATTTGTTTATTTCTTCATCTGCTGATCCATTCCATGAATATG CACTATGCCCTTACTCTAGGCACAGGGGACAGAGCAGGAAACAAGAGGGGCACAGGCCCTGACCTCATGA ACACTGAATTCTAAAAATAAGTACATTGCCAGCTTTTGGAAAACTAAGCATGCTTACTCATTTTTATGGC TGAGTCAGAGATGTTGAAACTTCTTAAATGTCACTGTCACCTTCTGGAAGCCTTAATGTGTATAAAGGGT TTGACTAAATGCTGGTTTAGCAAACTATAGTTTAAATATTATAAAGGCATAGCCTCAGCCTAAAATTATT GAAGAAAAAAAGATTATGTTCCAATTACTTTTGCCCTAATTACCAGAAAAAAATTTAAAATATAAAAACC ACAGGCCTGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGGCAGGCAGATCACGA GGTCAGGAGATCGAGACCATCCTGGCCAATATGGTGAAACCCCATCTCTACTAAAATACAAAAAATTAGC CGGGCGTGGTGGTGTACGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGTGGAATCGCTTGAACCCA GGAGGTGGAGGTTGCAGTGAGCCGAGATCACACCATTGCACTCCAGCCTGGTGACAGAGCAAGACTCCAT ATCAAAAAAATAAAAAAAAGACCCTCATCAGTACAACTGCTAAGTAAACATGAATCTTAAGTGCACATAA GATTTTAAATGTAAATCCAGTTTCAGACTCCTTATAATTATTTTTCTTGATAAAAATGGTAAAACTAACT TTTTAAAAACTTCATTTTGCTATGAAAATGATCAGTAAAATCAAGCACTGTTGTGTCATTACAGCTTTTT TTCACACAGATTTGGCCACCAACCAAGATGGATGGGACAGTTGAAGGGAGTGGCAATGTTCTTTCTGGAG AAACCAAGATTTGCCTGGTGGGGCAGGTAGCAGCGGAGGTGAGATGTGATGGCCTTAACAGTGTATAAAT TTAGTAGTTACCATCTATTTGGTACTTATTAGGTGCCAGACATGGTGCTTAGCACCATATACATACAATC TCATTTAATCCTCAACCACAATAAGTAGGTACTACTATTTTCCCCATTTTTCAGATGAAGATACTGAGTC TGAGAGAGCCACTTTGCCCAAGATCACACAGCTATTAATTGGGAAAGCTAGGATTTAAAGCAGATCTACT CTAGAGCTGAGGACTCACCTGTGACCCAGTCCTTACTCCTTCAGGTAGAAGACAAGTTGCATTTGTTCTG TGTTCAAATTCCAGGCCCTTGGATCTCTTACTTTTAAAGGCTCTACTCCATTTTTTTTTTTTTTTTTTCT GAGAAAGGGTCTCGCTCTGTTGCCCAGGTTTGGAGTACAGTGGCACCAACTCGGCTCAGTGAATCCTCAA CCTCCTGAGTTCAAGCAATCTTCCTGCCTCAGCCCTGCCAAGTAGCTGGGACTACAGGCACATGCCACCA TGCCCGGCTATTTTTTTTTTTTTTTTTTTTTTTGGGATGGAATCTCGCTCTGTTTTCCAGGCTTCAGGAC AGTGGTGAGATCTCGGTTCACTCCTCCCAGGCTCAGACAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGG AATTATAGGCATGCACCACCATGACCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGGTTTCACCATCT TGGCCAGGCTGGCTTAAACTCCTGACCTCAGGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGGGATTA CAGGTGTGAGCCACTGCACTCAGCCTAATTTTTTGTATTCTTAGTAGAGATGGGGTTTTGCCATGTTGCC CAGGCTGGTCTTGAACTCCTGAGCTCCAGTGATCTGCCTGCCTTGGCCTCCCATAGTGCTGGGATTACAC ATGTGAGCCACTGTGCCCAGCCCCATTTTTATATTAAATGCTCCCACATCCCACATTTAGAGTTGGTTTG CCAGCAGCCAATTTACATAATGTTACATATTATAGACAAACCATTAAATATTCATTCATTTCAATTTTTT ATTTTATTTTCCTATTTAGGAGCTACTGACCTATTTTTGGTTGTTTCAATATTTTTTCTCAGTCAGGCCC TTGAGAAGCTCAGAGGTTCGAGGTATTATTCCTATATTCCCATTTTTGTTGCCCTAGAGGGAAGGAACTA ACAAACAAAAACTAAAGGGAAGGCTGGGCGTGGTGGCTTACACCTGTAATCCCAGCGCTTTGGGAGGCCG AGGCAGAGGGATCACCTGAGGTTAGGAGTTCGAGACCAGCATGGCCACCATGGTGAAACCCCGTCTCTAA TAAAAATACAAAAATTAGCGGGGCGTGGTGGCGCGCGTCTGTAATCCCAGCTACTTGGGAGGCTGAGGCA GGAGAATGGCATGAACCTGGGAGGCAGAGTTTGCAGTGAGCCAAGATCGTGTCATTGCACTCCAGCCTGG GTGAGAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAGGAAAGAAAAACTAAAGGAAAGAAGACTTCTG TCTGTGGTAGAGACAAGTATAAGGAAATGCACCACCTCGACAGGGAGTGAACTCCGTCTACAGCAAATGC CCATTCAGTGGTGATGTAGTAAAAAGTACTGGCCGGGCGCGGTGGCTCACGCGTGTAATCCCAGCACTTT GGGAGGCCGAGGCGGGAGGATCACAAGGTCAGGAGATGGAGACCATCCTGGCTAACACGGTGAAACTCTG TCTCTACTAAAAATACAAAAAAGAAAAAAATTAGCTGGGCTTGATGGTGGGCGCCTGTAGTCCCAGCTAC TTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAACTTGCAGTGAGCCGAGATTGCGCCA CTGCACTCTAGTCTGGGTGACAGAGCAAGACTCCGTCTCAATTAAAAAAAAAAAAAAAAGTACTGAAGCA CAGGATGGGAAAGTGAGACTAAATGACCCTTGAAGTCCCTTCTAGCACTATGGTTGTAAGATTCTTTAAA ATATAACAATGGCATACAATAAGTATCTGGTATAACTTTATTATTTTCTGTCCCCACCATATTTAGTTTC CTCTCTAATTGCATAAAAGATGTTGGCTACCAATCACTAAAGACTAACCAAAGACTGAAACTTTGGAGAG CTAAAACCAGTAACTATAGTAATAATAAACAGTTGAGTGCTTTTTATGGGCCAGGTACTATGCTGAGCAT TTTACATACATTATCATGTTTATACATTACAACCACCTCATGACATGGGCACTGGAATTATCCTCATTGT AGAGATGAGCAAACTGAGCTTCAGAGAATTTGAGCAACTTGACTGAGGTCACAGAGCTATCAAGAACAGC TGAAATTAGAACCCATTCCACCTGTCACTGAAGTACTTTAACCACAATCTCACTGTGCCTCCTGATCTTA TAATATTAACGACAACAGCTAACATGTACAAATTGTGGTCAGACATTGGGATAAACGTTTTAGACATTTT CTTATTTAAAGCCCATAAGGTGTGATTTATGAGATTTATGACATTATGAGGTGGGACTCACCTATTAACC TCATTTTACAGAAGAAAAAAAAAATGGAGCTCCAGAGAGTTTAGAAGAGACCAGGACACTGACAAGAAAT ACCTTAAAATTAACCTTCATGATCAATGTGACTTGACTTCTGCTTTATGCCCAGTGTTCTCTTCTGGAGC ACCCTGAGTACGTCCTTGCTGAATTACATGAAGAATTTAACTATTCTTTCTGTGGCTGGAATCCAGGGAA GGTGATGGGCTTTATTCTAGCTAGAAGGCATCCTAGAAATCACCTAATCCAATGTGTCAGTTCCCAAACA CAGACTGACACCAGTTCATGACCAAACATCACCAGTCCAGGGTCAGTCAGAAAATGTGGACAAAGTAATG AGCATTTCATTCAATTTAGTTAATATTTAAGTAAAATTAAAGACTATAAAGTTTATTAACTTTTTTCCAG TTAAAATTTAAGTAAAATAATCCTAAGCCAGACCATCTTTTTCCCAGCACAGGTGTGTCTCCACCACTTC CCTCTTTTCAAACACTATTTCAGGTGCACGGAGATATCCATGCCTCCACTCTCACACTGTTTTCTCATCT TTTTTTCCCACATTCAAAATCCTCTGAATTCAGAGCCAGCTAAAGATTCCCTCCTCTGCCCCATGCATAG TTACCTGGGCCATGTCCCCTGGTGGTAAGCATCCTTGGAAAGGCTGCAGTGAAGTCTCTCTGCCGAGTCG GTGCAGGGGTGACCTTGGCTAATGTCAGAAACAACATAAGGATGAAAATTATCTGAGAGCAGAAAGCTTA TTTCAGGGAATCAAAGGGGCAGCAAGAAAAAAATGCGAAAGACAATTAAGAAAGAGAAATACACCCTCAG CTTCCAAACCTGCCTGGATACCTACGTTGAGAGTGTATCACACACTTCAAATGTTTGACAAAGGTAAGAT GCAGTCATCATTGTTACATTCTGATTATTAATAGCGGAACTAACAGCCACACAAATGGCCATAATTACAG GTTGAAGACTCCTTATCTGAAATGCTTGAGATCAGAAATGTTTTAGATTTTGAATTTTTTTTTTTTTTTT GAAACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCATAATCTCGGCTCACTGCAACCTCCG CCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGACTCCTGAGTAGCTGGGACTACAGGCATGTGCAACCAC ACCTGGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTTGGTCAGACTGGTCTCGAACTCCC GACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACCACGCCCAG CCATGTTTTTATTTTTTTATTTTTTAGTATCTGCCTATACTTATGTTCCAATGAGCTTTTCCTTTGAATG TCATGTCAGTGTCCAAAAAGTTTTGGATTTTAGAGCATTTCAGATTTTGGTGCATTTTAGGTTTTAGATT TTCAGATTTGGGATGCCCAACCTATAAAGGCTTTTAATAAAATATTATCACATAAAATCCTTCTAATGGC CCACATGATCGGTATTATTGTCATATTTTATAGAAGAGGAGCTCACAGCGTTTCAATAACTTGCTCAGGA TTATATAGCTAGTAAGAGGCAGAGTTAGATGTAAACTCAGCTCTATCTGGGCACAAAGTACATGTTATAG AAATCTTAAGTCTGTTCACCTCCCAGCATACATGCATAACCCAGCAGTTCACCATGCTGGCTGCACCTGG GGTAAAATCACCTGAGGTAGACTCTGTAAAAAGCTAATGCTTAGCATCTACCTCCAGAGATGCTGATTTC TCTGGTTTTTGGTAGTGGGGTTTTTTCTTCTGCTTTTTAAGAGATAGGGGTAGCCACAGTATATCAGCCA GGCTGGTCTCAAACTCCTGACCTCAAGTGATCCTCCTGCTTCAGCCTCTCAAAGTATTGGGATTATAGGC ATGAGCCACTGTACCTGGCATCTATAGTTGTTTAAAAACTCTCTATGTGATTCTAATGAGAGTCAGGGTC TCTAACCACTGATCTAGGCCTTTCATCCCATCTATACATTCCACCCATGAGTTTTGGCTTTTCTTTTCTT TTCTTTTTTTTTTTTTGAGACAGAGTTTCACCCTTGTCAGCCAGGCTGGAGTACAATGGCGAGATCTTGG CTTACCACAACCTCCGACTCCCAGGTTCAAGTGATTCTCCTGCTTCAGCCCCCCAAGTAGCTAGAATTAC AGGCTCCCGTAACCATGCCTGGCTAATTTTTTGTATTTTTAGTGGAGACAAGGTTTTACTATGTTGGCCA GGCTGGTCTCGAATTCCTGACCTCATGATCCACCGGCCTCAGCCTCCCAAAGTGCTGGGATTAGAGGTGT GAGCCACCACGCCCAGGCACACCCATGAGTTTTAAAACAGAGAGAAGGTGTTAAATATCACTGAGCATCA CCAATGGGGCCTGTTAAACTTTAGGTCTTAGTGGCCCTCCTCCAGGGCTATAATTAGGGAAGTCAGAGAT GAGAACAATCAGTACCTTTAATATGATCCACAGATAAATCTTATTCATAAAGATGGCATGCAAATGTCCA CTCACCTGGTTTGATGACCAACTTCAGGTTAAATTTTTCATCATTCATTATGCCTGGGATTTGGATCCGG CAGCAGTAGATCCCACTGTCTGCTAGAGTCACATTCTCTATGGTCAGGGACACATCTCCTTTGCGGAAAT CCCCATTTAGCCAGTATCTGGATGTCCAATAATTCACATCCCTTTCATCAGTCCTGAGCACCACGTTGCC ACATTCAAACACAGGACAGGCTCCTTTGCCCCAGCAGACGGGCACGAGGTTCCCTGGGGCGGCTGGGGTG TAGAAGCAGGGCAGATAGGCATTCTGACCGACCTCCGCTCTGTATTCCACTTCTGAGGACCCTGCATAGA GAGAGAAGGAGAGCCAAGACTCAAGCGGTGAGTGAGGTTACTCCATTTCAGGAAAACTGCAAGCCATGTC TTACAGAATAAAGAGGAAGCTACTGCTGCAGTCCTGTTTGGAGGATGATTCGCTGTGACAATGCTTCTCA GATGTGAAGGCCATCAGAATCACTGGGAAGCCTTGCGAAAACACAGATTGCTGGGCTCAACTGCTAGAGT TCCTGACTCAGTTGGCCTGTGGTAGAGCCTGAGAACTTTTATTTCTAACAAGTTCTCAAGTGTTGCTGAA GTGGCTGGTCTCAGAACCTCACTTTCAGAAACACTGCCCTAGGAGAGAATTGTGGCCCAATTCTGTGAAC ACGGGAGAACAGGGCTGATGGAAACAGACAATCAGAAAATTAGTCATGGTCAGCCAGGAAACGGCCCGCC CATCTGGGCTACTTGCTTGTTCATCAACAAAGGGAGGCTCTCCTAACATACTTCTCTTTTTAAGCAGCAA GTGCACAGTAAATACAAACCCTTGGTTAAATAAGGATCTTGTGTATTTGAAACTACTCATGGAGTTGTTT TAAGGTTTAAAGTTGTGAAAAGAAATTAAATTTTGGGACCCCAAACTCATTCAGTCAAAGGGAAAAGTCA AGCTGGGAACTGGGTCACAGAAACCTGCCTCCTCTTTTTGATTCCTGAATAAGATGGCTACAGGATGAAA GGCTGCATACCTCCCCCATATTTTGCCCACAAGGAAATTCCTGGTCAGCTGTGCAATGCAGATTGATAGC TCATCTTTACCGGTGCGGTCACCCTGGCCAGACACAAATGCGTTATCTGATTGTTTCCCTACCCCATTTT GTCTGTGTTATCTAATGTAAAATGCAGATTCCCCATATTTTTCCTCTGCCCCCCCCCCTTTTTTATGTGA AAACTGAGTGCTTCTCAATATCCCACCTTGTCCCCTTTAAATCTGGAGCCCTCAAAATCATCTTCTGAGA AAGTCATAGACCTGTCTCTCAGGTGCCTCCTTAACTTTGGCAAACAAATCTCCTAAAATGATTGAGACTT GTCTCCTCATTTTCCTCAAATGACAAAGTTAATTCCATTAAAAAAAAACTATATATATTTTATATATGAT AAAACATTCATTATATATTTTCTTTTGATTTTTTATGTCCCCTTTGTTTTCATATGACTCAACTACAGTA AAAACATTCAAACACTATCAAAGGTGTATGAAAAAGTGGCCGGGCACACGGTGGGTCACGCCTGTAATCC CAGCACTTTGGGAGGCTGAGATGGGCAGATTACTTGAGGCCATGAGTTTGAGACCAGCCTGACCAACATG GTAAAACCCTGTCTCTACTAAAAATTAAAAACATTAGCTGGGTGTGGTGGTGCACGCCTGTGATCCCAGC TACTCCGGTGCCTAAGGCAGGAGAATCACTTGAACCTGGGAGGCGGAGATTGCAGTGAGCCAAAATGGTG CCACCACTGCACTCCAGCCTGGGCAATAGAGTGAGACTCCATCTCAATTGAAAAAAAGAAAAAGAAAGAA AAGAAAAAGAAAAAAAGGAAAGAAAAGAAAAGAAAAATATGCCTTACTCTCCCAACTCTTTACCATTCCC TGGTTCCTTTTCCTAGAGCTTATACATTAAGAAATGTCCACATATTCCTGCTCCCCGACAATGCACACAC ACAAATAGAAGCCTAATATATGCATTATTCTGCAACTTTTTTTCTTTAATAACATTATAATTTTGAGACA TTCTATACCAGTATGTTTTGTCAGACTCACTGTTTGTATCATGATTATATCACATTTATTTACCCACTCC CTCATCGACGGACATTTAGGTTGCTTCCAAGCTTTTGCTATTACAAACAACATTACAATGGCCATCCTTG TATCTCTCCCTTGTCCTCTGTACAGCACCATTATGTCATTGTAAATATCCATGCCGAGACTTACTTGTAA GTAGTAGCAGCAGCAGCAGCAGGACACAGTCAAAGGGAAGATGTGAAAACATGGAGCTTGCAGAAGAAAA GTCAGAGGACACCTCTGTTAGGCACAGTTTTAACTCTCCAAAT
Protein Name HAVR2_HUMAN
Length 301
Moltype AA
Topology linear
Division PRI
Update Date 12-OCT-2022
Create Date 27-SEP-2005
Definition RecName: Full=Hepatitis A virus cellular receptor 2; Short=HAVcr-2; AltName: Full=T-cell immunoglobulin and mucin domain-containing protein 3; Short=TIMD-3; AltName: Full=T-cell immunoglobulin mucin receptor 3; Short=TIM-3; AltName: Full=T-cell membrane protein 3; AltName: CD_antigen=CD366; Flags: Precursor
Primary Accession Q8TDQ0
Accession Version Q8TDQ0.3
Other SeqIDs sp|Q8TDQ0.3|HAVR2_HUMAN,gi|311033536
Organism Homo sapiens
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Comment On Nov 3, 2010 this sequence version replaced Q8TDQ0.2.; [FUNCTION] Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity). {ECO:0000250|UniProtKB:Q8VIM0, ECO:0000269|PubMed:11823861, ECO:0000269|PubMed:14556005, ECO:0000269|PubMed:16286920, ECO:0000269|PubMed:22323453, ECO:0000269|PubMed:23555261, ECO:0000269|PubMed:24838857, ECO:0000269|PubMed:26492563, ECO:0000269|PubMed:30374066, ECO:0000305|PubMed:24825777}.; [SUBUNIT] Interacts with HMGB1; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response (By similarity). Interacts with BAG6 (By similarity). Interacts (phosphorylated) with PIK3R1 and PIK3R2. Interacts (not dependent on its phosphorylation status) with FYN (By similarity). Interacts (in basal state T-cells) with VAV1; AKT1/2, LCP2, ZAP70, SYK, PIK3R1, FYN, SH3BP2 and SH2D2A. Interacts (in activated T-cells) with LCK and PLCG (PubMed:26492563, PubMed:24337741). Interacts with ILF3; this interaction promotes ILF3 ubiquitination and degradation (PubMed:34110282). {ECO:0000250|UniProtKB:Q8VIM0, ECO:0000269|PubMed:24337741, ECO:0000269|PubMed:26492563, ECO:0000269|PubMed:34110282}.; [INTERACTION] Q8TDQ0; P13688: CEACAM1; NbExp=4; IntAct=EBI-11472922, EBI-4314481; Q8TDQ0; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-11472922, EBI-8652744; Q8TDQ0; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-11472922, EBI-12015604.; [SUBCELLULAR LOCATION] Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000269|PubMed:24337741}. Cell membrane {ECO:0000269|PubMed:30374066}. Note=Localizes to the immunological synapse between CD8+ T-cells and target cells. {ECO:0000269|PubMed:24337741}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TDQ0-1; Sequence=Displayed; Name=2; IsoId=Q8TDQ0-2; Sequence=VSP_017287, VSP_017288.; [TISSUE SPECIFICITY] Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells. {ECO:0000269|PubMed:11823861, ECO:0000269|PubMed:17069754, ECO:0000269|PubMed:18006747, ECO:0000269|PubMed:19001139, ECO:0000269|PubMed:19587053, ECO:0000269|PubMed:22323453, ECO:0000269|PubMed:22383801, ECO:0000269|PubMed:24838857}.; [PTM] O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:22171320}.; [PTM] Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9. {ECO:0000250|UniProtKB:Q8VIM0, ECO:0000269|PubMed:17069754, ECO:0000269|PubMed:24337741}.; [DISEASE] Note=May be involved in T-cell exhaustion associated with chronic viral infections such as with human immunodeficiency virus (HIV) and hepatitic C virus (HCV). {ECO:0000269|PubMed:19001139, ECO:0000269|PubMed:19587053}.; [DISEASE] T-cell lymphoma, subcutaneous panniculitis-like (SPTCL) [MIM:618398]: An uncommon form of T-cell non-Hodgkin lymphoma, in which cytotoxic CD8+ T-cells infiltrate subcutaneous adipose tissue, and rimming adipocytes in a lace-like pattern. Affected individuals typically present with multiple subcutaneous nodules, systemic B-cell symptoms, and, in a subset of cases, autoimmune disorders, most commonly systemic lupus erythematosus. A subset of patients develop hemophagocytic lymphohistiocytosis. SPTCL transmission pattern is consistent with autosomal recessive inheritance with incomplete penetrance. {ECO:0000269|PubMed:30374066, ECO:0000269|PubMed:30792187, ECO:0000269|Ref.2}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the immunoglobulin superfamily. TIM family. {ECO:0000305}.; [CAUTION] Experimental results based on the injection of HAVCR2/TIM-3 antibodies or use of HAVCR2/TIM-3-Fc fusion proteins can reflect changes in the activity of several cell types and pathways as HAVCR2/TIM-3 is expressed by multiple immune cell types. {ECO:0000305|PubMed:24825777}.
Source Db UniProtKB: locus HAVR2_HUMAN, accession Q8TDQ0;; class: standard.; extra accessions:B2RAY2,Q8WW60,Q96K94; created: Sep 27, 2005.; sequence updated: Nov 2, 2010.; annotation updated: Oct 12, 2022.; xrefs: AF251707.1, AAM19100.1, AY069944.1, AAL55401.1, AK027334.1, BAB55044.1, AK314406.1, BAG37029.1, AC011377.6, CH471062.2, EAW61614.1, BC020843.1, AAH20843.1, BC063431.1, AAH63431.1, NP_116171.3, 5DZL_A, 5DZL_B, 5F71_A, 5F71_B, 6DHB_A, 6TXZ_A, 6TXZ_B, 6TXZ_C, 6TXZ_D, 7KQL_T, 7M3Y_B, 7M3Z_A, 7M41_A, 7M41_B; xrefs (non-sequence databases): CCDS:CCDS4333.1, PDBsum:5DZL, PDBsum:5F71, PDBsum:6DHB, PDBsum:6TXZ, PDBsum:7KQL, PDBsum:7M3Y, PDBsum:7M3Z, PDBsum:7M41, AlphaFoldDB:Q8TDQ0, SMR:Q8TDQ0, BioGRID:124313, DIP:DIP-61459N, IntAct:Q8TDQ0, STRING:9606.ENSP00000312002, ChEMBL:CHEMBL4630879, GlyConnect:712, GlyGen:Q8TDQ0, iPTMnet:Q8TDQ0, PhosphoSitePlus:Q8TDQ0, BioMuta:HAVCR2, DMDM:311033536, jPOST:Q8TDQ0, MassIVE:Q8TDQ0, PaxDb:Q8TDQ0, PeptideAtlas:Q8TDQ0, PRIDE:Q8TDQ0, ProteomicsDB:74319, ProteomicsDB:74320, ABCD:Q8TDQ0, Antibodypedia:2450, CPTC:Q8TDQ0, DNASU:84868, Ensembl:ENST00000307851.9, Ensembl:ENSP00000312002.4, Ensembl:ENSG00000135077.10, Ensembl:ENST00000696899.1, Ensembl:ENSP00000512960.1, GeneID:84868, KEGG:hsa:84868, MANE-Select:ENST00000307851.9, UCSC:uc003lwk.3, CTD:84868, DisGeNET:84868, GeneCards:HAVCR2, HGNC:18437, HPA:ENSG00000135077, MalaCards:HAVCR2, MIM:606652, MIM:618398, neXtProt:NX_Q8TDQ0, OpenTargets:ENSG00000135077, Orphanet:86884, PharmGKB:PA134883425, VEuPathDB:HostDB:ENSG00000135077, eggNOG:ENOG502S454, GeneTree:ENSGT00940000154444, InParanoid:Q8TDQ0, OMA:EHGPAET, OrthoDB:1147868at2759, PhylomeDB:Q8TDQ0, TreeFam:TF336163, PathwayCommons:Q8TDQ0, Reactome:R-HSA-451927, SignaLink:Q8TDQ0, BioGRID-ORCS:84868, ChiTaRS:HAVCR2, GeneWiki:HAVCR2, GenomeRNAi:84868, Pharos:Q8TDQ0, PRO:PR:Q8TDQ0, Proteomes:UP000005640, RNAct:Q8TDQ0, Bgee:ENSG00000135077, ExpressionAtlas:Q8TDQ0, Genevisible:Q8TDQ0, GO:0070161, GO:0009986, GO:0005769, GO:0001772, GO:0016021, GO:0046872, GO:0002250, GO:0071222, GO:0050830, GO:0006954, GO:0045087, GO:0002281, GO:0060135, GO:0002519, GO:1900425, GO:0010629, GO:0071656, GO:2000521, GO:0032687, GO:0032689, GO:0032703, GO:0032712, GO:0032715, GO:0030886, GO:0032815, GO:0002859, GO:0032088, GO:2001189, GO:0042130, GO:0002826, GO:0032720, GO:0032722, GO:1900426, GO:0070374, GO:0045089, GO:0032729, GO:0032732, GO:0032753, GO:0043032, GO:1901224, GO:0042102, GO:0032760, GO:0002652, GO:0034138, GO:0034154, GO:0034162, Gene3D:2.60.40.10, InterPro:IPR007110, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003599, InterPro:IPR013106, Pfam:PF07686, SMART:SM00409, SUPFAM:SSF48726, PROSITE:PS50835
Sequence mfshlpfdcvlllllllltrsseveyraevgqnaylpcfytpaapgnlvpvcwgkgacpvfecgnvvlrtderdvnywtsrywlngdfrkgdvsltienvtladsgiyccriqipgimndekfnlklvikpakvtpaptrqrdftaafprmlttrghgpaetqtlgslpdinltqistlanelrdsrlandlrdsgatirigiyigagicaglalalifgalifkwyshskekiqnlslislanlppsglanavaegirseeniytieenvyeveepneyycyvssrqqpsqplgcrfamp