VAEAG: Vaccine Adverse Events Associate with Gene

Record Information
Record ID	47
Pubmed ID	31320597
SNP
Gene ID	2064
Protein ID	P04626
Vaccine Adverse Events	fatigue, convulsions, and nausea
Vaccine	Dendritic Cell Vaccine ICT-107
Gene Name	ERBB2
Official Symbol	erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)]
Aliases	CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2)
Other Designations	receptor tyrosine-protein kinase erbB-2; c-erb B2/neu protein; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; proto-oncogene Neu; proto-oncogene c-ErbB-2; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Chromosome	17
Location	17q12
Annotation	Chromosome 17 NC_000017.11 (39688094..39728658)
MIM	164870
DNA Sequence	>NC_000017.11:39688094-39728658 Homo sapiens chromosome 17, GRCh38.p14 Primary Assembly GTTCTTTATTCTACTCTCCGCTGAAGTCCACACAGTTTAAATTAAAGTTCCCGGATTTTTGTGGGCGCCT GCCCCGCCCCTCGTCCCCCTGCTGTGTCCATATATCGAGGCGATAGGGTTAAGGGAAGGCGGACGCCTGA TGGGTTAATGAGCAAACTGAAGTGTTTTCCATGATCTTTTTTGAGGTAGGGCTGTTTACTGTCACCACCC CTGTCGGATTTTACTTCCTAAACGTACCTGTAACTATCCACTTCTCTCCATCTCTTCTGGCACCACCCTG GTTAAAGACACCATCATGTGTCGCCAAGACAGCCGCAGTAGCTTCTTAATGGCTCTCCCTGCCTCTACTT TTGCCTCTTCCAACCTGCGCTCCATTTTGAAAAATTAAAATTTGCCCATATCACTTTTTTTTTCTTAAAA TTATTTACTGGCTCCCAATTACCTTGGGTAAAATACAGTCTCCACAAACCCTGCCTGATTTGGCCCCTGT CCACTGGTCTCCCTCACTCCCTTGCTCCAGACCCGCTTCAGAGGGCTATGTCCCTCAAGCTTCCTGACTG CCTGGCCTGGTCTGAATCACTCACTCTTCTTTTTTCTTCTAGTCGCAATTGAAGTACCACCTCCCGAGGG TGATTGCTTCCCCATGCGGGGTAGAACCTTTGCTGTCCTGTTCACCACTCTACCTCCAGCACAGAATTTG GCTTATGGTAGGCGCTAACTGCGTTTGTTTGTTCTTCTGTTTAATGAATGAACAGCATACATCAACATAA GAACTTGACAAATCCAGGGCTGTAAAATCATCAGTATGGTTCTGCACTGAGATCGGAGAGAAGTAATATT TCTAGGAAAATTAGGAACCCTGGGAACAGGACGCTTGCTTTAGTATCCTCTCCCTGCTCACCTCCCCTGC ACTCCCATCAGCACCGACCCACACCCAATCTCATAGAAGCCTTGTAGCTAAGGATCACCCTTTCTCCTCC CCCACTCTCCTCACCCCTTGTCAACTTTTCTTTTTCGTCCTGGGGGTTGGAATGAGTAAGAAGTAGCCTG GGATTCCATTCACTCACTTAACAAACATTTCTGAGTCCTTAGCTCTAGCACCTTGCTAAGCAAGGCAAAA TCTCCAGGAGGCACCATTCACATTGCATTTTCTGTGAATGGTGCTCTGGGGAGCAGCATTCACATTGCCT TTTCTGTGAATGGCAAATTCTTCCAGTTAAATATAACATGAATAGTGTCCCCTGGAGTTGACCACCCAAC TGATACTGACTGAGAAGCTGAAATGAACAAAACAACCCCTTAGCCCTCCAGGAGCTGACCGGAAATCCAG TGCTAATACTACTTTGCATCTTACAGATTAGTTCTTTTACAATACTGTTTTTTTTTCTTTTTTCATTTCA TTTTGTCCTTTCTGTGACTCTGGGATGAGTCTTTTTATGAGGATCCTCATATAAAGATGGACATTTAGGA TTAAAGAGGATGAAATCCTGACAAAATAGGGAGTCTCCCCTTTAGAAAATTCCTAAGTAAGGCTGGGGGT GGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGACGGATCACCTGAGGTTAGGAGTTT GAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGTTGGGTGTGGTGGT GCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGGAGGCAGAGGT TGTGGTGAGCCAAGATTGCGCCATCGCACTCCAGCCTGGGCAACAAGAGCGAAACTCAAAAAAAAAAAAA AAAAGAAAAAGAAAATTCCAATTTTGAAGGCCTCATCCTATATTATGTCAAACATACTGAAATGCAGTAA CGCCCCACATTAAATAAGATTTATAAATAACTATACATATATATAATTCAATCTAATTGCTGTTAATAGT TGACATATTGCTACATTTATATACATTTAGTTAAAAAAAATTTTTTTTCCCAGACAGCCTCTCACTCTTT CACCTAGACTGAAGTGCAGTGGCATGATCACGACTCACTGCAACCTCAACCTCCCAGACTCAAGTGATCC TTCCATCTCAGCCTCCTGAGTAGCTGGGACTGCAGCATGCGCCACTATGCCCTGCTAATTTTTTTAATTT TTTGTAGAGACACGGTCTTGCTATGTTGCCTAGACTGGTCTCCAATTCCTGGGCTCGAGTGATCCTCCCG CCTCAACCTCCCAAAGTGCTGGGATTACGGGCGTGAGCCATGCCACACGGCCATAAAATATTAATTTTCG CAGCTTTCTTATATTTTAGAACTAACAATGGAAATTTGTTCGGGTCTAAAGTATTTCAGAGGTCCTTGAA AACCCATGCCTACATACCTGATGGAAAAAGCAATCCTAGGTTAATGGTGGAAGTGGGAGTAGAGACTTCT GTTCTGTTGACTTCTTGGAAGATGGGGTACTGTCTCTCTGGGACAGCTCTTGAGAATTTCCCTGCCAGCA CAGCCCCAGATAACAATCTCTAGATGGCGATTACCTGGCCTCTCTTCCCAACTTTCTAGCCTGGAGCCCC TAGTTCTCCCCTGAGCCTCCTTAGCTTGTCCTTCTTCCTAACTTGTATTTGGCTTCAGATGTGATCCACA GTCTGAAAAGTCACTAATTCATTCCTTCAACTCAGGCTTATTGAGTCCTCCTGTGTATCAGCCATTGTAC TCATGGGGGAAAAAAAAGACAAAGCATATGTTAATAGTAGAGTGTGCTGGACAGGCACAGTGGCTCATGC CTGTAATCCCAGCACTTTGGGAGGGCGAGGCAGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCCTG ACCTAACATGGAGAAACTCCTGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCCGT TTCAAAAAAAAAAAAAAAAGTATAGTGTGCTAAAGGCTCAACGGCAAGCTGACCATGTTCTTAGATCAAA ATTGGTAGAGAGTCTACAATGTGGGTTCCTTATTCATCAAATGTTTATTAAGTTTACCATGTGCAAGTCT CTGGGAACAGAGTGATGAACAAGGCACTGTACTTTTCATGGTCAGAGGAGGGAAACAGGCCATAAACAAG TGTCAAACAAAAGACTGAAGCCAGGTGCGGTGGCTCACATCTGTAATCCCAGCACTGTGGGAGGCCAAGG CAGGCGGATCATGAGATCAGGAGATCGAGACCATCCTAGCCAACATGGTGAAACCCCATCTCTACTAAAA ATACAAAAAAATTAGCTGGGCATGGTGGCACGTGCCTGTAATCCCAGCTACTCCGGAAGCTGAGGCAGGA GAATTGCTTGAACCAGGGAGTTGGAGGTTGCAGTGAGCCTGGATTATGCCACTGCACTCCAGCCTGGTGA CAGAGCGAGACTCCATCTACATTAAAAAAAAAAATATATATATATATATATACACACACACACACACACA CACACACATACCCTCTAACCCAGGAATTTCACTCCTAGGTATACCTACATAAGCTCCAGTATACCTAAAC AAGTGCAAATTTGTTTAAGTACAGTTATTTGTGGTAGCATTAGTCATTGTTTTCAATAGCAAGAAGAAAA AGGAAACAACTAAATGTCCATCAATAGGGAATGAATTATATTAATGGAGGGAGAGCCATACAATGGAAGG CTGAACAGAAATTAATAGGAATGGGGCAGATTTGTAATGTACTAGCATGGTAAAACCTTCATGATAGATA TAGATATAGATATAGATATAGATATAGATATATATACATATACATATACATATACATATACATATATATA TATATATATATATATCTCTTGTGTCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTGCCACCACATC CGGCTAATTTTTGTATTTTTTAGTAGAGACAGGGCTTCACCATGTTGGTAAGGCTGTCTTGAACTCCCGA CCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCATCACACCTGGCC AAATATTTTTGATAAGTATCAAGTGCACAGTGCAGAACAAAATATGTGTGTGTGTATGCATGTGTATGTA CACCTATACACTTATATACAGTACCCCATGTGAAGAAAAATAAGGGTACGTGTTATGCGCGTAGTATTAT GGTTGTTATTTTTGAGAATATATCTAGAAAGATAAAAAAGAAAGTGGAAATAGTTCTTGCCTCTGGTGGG AAGTGGGACTATGTGCCTGATCAATAGGGAAGTAAGGAACACTTTTTTTTTTTTTTTTTAAACGGAGTTT TTGCTCTTGTTACCCAGGTTGGAGTGCAATGGCGCGATCTTAGCTCACTGCAACCTCTGCCTCCCAGGTT CAAGCGATTCTGCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCATGCGCCTCCACGCCTGGCTAAT TTTGTATTTTTAGTAAAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTTGAACTCCCCACCTCAGGTG ATCCGTCCGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGTGCCTGGCCAGGAACGCT TTTTATTTTTGTACCTTTAAAAGTGTGTACCGTCTGTGTATATAATCAGTTAAAAACAAAGAAAAGCTGA GTGTGGTGGCTCATGCCTGTAATCCCAGCCCTTAAGGAGGCCGAGGCCGGCGGCAGATCACCTGAGGTCA GGAGTTCAAGACCGGCCTGACCAAAACGGTGAAAACTCATCTCTACAAAAACATAAAAATTAGCCAGGCA TGATGGCAAGTGCCTGTAATCCCAGCTGGTTGGGAGGCTGAGGTGGGAGACTTGCTTGAACCTAGGAGGC AGAGATTGCAGTGAGCCAAGACTGTACCACTGCACTCCAGCCTGGGCAACAGAGCAAGTCTCTGTCTCAA AACAAAAACAAAAACACAAAGAAAAAATGTAAAACAATTTCATGCAGTAGCAAGCATCGAGTTAAATACA GTTGACCCTTGAACAACACAGGTTTGAATTGCACGGGTCCATTTATACTCACATTTCTTCCACCTCTGCC ACCCCCAAAATAGCAAGACCAACCCCATCTCTTTTCCTTTCTCTTCCCCCTCCTCAGCCTACTCAATGTG AAGATGATGAGGATGAAAACCTTTGTGATGATCCACTTCCACTTAATGAATGGTAAATATGTTTTTTCTT ACTTATGATTTTCTTAGTAGCATTTTCTTTTCTCTAGCTTCCTTTATTGTAAAAATACAGTATATAACAC ATATCACATACAAAATGTGTGTAAATGGACTGTTTGCTATTGATAAGTATTCTGGTAAACAGTAGACTAT TAGTTTTTTTTGTTTTGTGACAAGGTCTCCCTCTGTCGCCCAGCCTGGAATGCCGTGGTGTGATCATGGC TCACTGCAGCCAAAAACTTCTGGGCTAAAGCAATCCTCTACTAAAAATACAAAAATTAGCCAGGCATGGT GGTGCGCTTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAG GTTGCAGTGAGCTGAGATTGCACCGTTGCATTCCAGCCTGGACAACAGAGCGAGACTCCATCTCGAAAAT AAAATAATAATAATAATAATAATAATAATAATAATAATAATAGGGCTGGGTGTGGTGGCTCATGCCTGTA ATCCCAGCACTTTGGGAGGCCAAGGTGGACAGATCACCTGAGGTCAGGAGTCTCAATTAAAAAATAAATA GGCCGGGCACAGTGGCTCATGCCCATAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACCTGAGG TCAGGAGTTTGAGACCAGCCTGGCCAACACGGAGAAACGCTGCCTCTATCAAAAATACAAAAATTAGCTG GATGTGGTGGTGCATGCTATAATCCCAGTAATACCAGCTACTCGGAAGGCTGAGGCAGGAGAATCACTCG AATCCGGGACACGGAGGTTGCAGTGAGCCGACATCATGCCACTGCGCTCCAGCCTGGGTGACAGTGAGAC TCTGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATATATATATATATATATATATATATA TATATATATATATATGTGTGTATATATATATATATACACATATATATGTGTATATATATATACACACACA CATATATATGTGTATATATAAAATAAAATAAATAATAATAAAACATTTACTTTGGCTGCTGTTGCTGCGG GGAGAATTGCAGGGTGTCAAAAGTAGCACTGGTGGAGGGGTAGTGATCAAAGTCTGGTGCTTTAGCCCAA AGGAGAAATGATAGAGACTCAGACTAGCTGGTGATGGAGGTAGAATAAGCATAAATGTATCAAAAAGAGG AGTTGATAGATCTTAAAGAATGATTGGATTTGAAGGGCAAAGGAAGAGAAGAATCAACCAGGTGGGTTCA GTGAATGAAACCATCAGAAACGAATTGTCCCCTGAAATCAAGACTTTGTGATTGCCATAGTTGTATGCTT CTCAAAGGTTCCTCGTCTCCTCTTCCTTGGACCAAAAGTCAGAGGCAAGAATGCCCTCATTCATACCCCA GTGGTCTATACCTCCAGCAGCAAGTCGAGTGAGCAAGTGATGTCCTGAAAGGCCCAGTGGATCAGTGGAA TGAAGCGGGCAGGAAGACTTAGTGCTCCTGAAACAAGGAATCCAGAATCCAGGAGAAGGATGGCTCAGTG GGGCTTTCAAGGGACAAGTATGGGGGTTGAAGGGGTCACTGTCCCTATACCAAATCCGAAAATATTGTGA CCAGGAACCATTCTGTCCAACTCTTCTATTTCAGGTGGCAAAGCAAAGCTATATTCAAGACCACATGCAA AGCTACTCCCTGAGCAAAGAGTCACAGATAAAACGGGGGCACCAGTAGAATGGCCAGGACAAACGCAGTG CAGCACAGAGACTCAGACCCTGGCAGCCATGCCTGCGCAGGCAGTGATGAGAGTGACATGTACTGTTGTG GACATGCACAAAAGTGAGGTGAGTCGCAGGACAGAAGAGTGCTTTTTGTTTCAGCAGAGCAGCCTGGGGA GAGATAAAAGCTACTCCTGGGGCCTGGGCCTGCATTCCTGAGATGTGGGTAAGAGGGGCCCAGGGTCAGA GTGTCTGGCAAGCTTGGCTCTGCCCCTTTGCTGTCCTGGAGACTAGGGCTAATCCTGGGCTCAGGGAGTG GCCTCCCCATGGTTAGGATACAAGTGCTCATCAAGGGCCACCCCTAGGAAGGACCAATTTTCCTATCAGA AGCTTCTAAGTTATCCTCCTTTGGCCCAAAGGGACACCTCAAGCCTACTCTGAGGAACTCTTTCCAATGA ACTAATTCCTACAGTCACTTCCCCAGCAACCTGTGCCTCAGCCTCAAGGCACTGTGGGGTAGGCCTCAGT TTGTGGCCTGGACATCGGACTGTGGACCAGACGACTCCTCCCGATTTCTGTTTGTTTTCAGTCCTCTGAC CCCAAGCTGGCTGGTGAAGTAGGTAGAGGGAGGAGACTTTGGTGCATGCATACACACACACACACACACA CACACACACACACACACACACACACACACACACACGTCTCCTGTGCCCCCCAGTCTCCATGGCTGGTCAA TGATTGACTGGCATTTCACAGGCCGCTGGTTGCAGCCCCAGCCTGTTGACTTAGAGGTCACCCTCGGAAG CTAGAGCCCTGTCCTGCCTCTTCAGTGTCAGTGGTCACTCCACTGCCCACAGGCTGGGGTCTTGGGCAAA ACACACGCATCTGCCCTGATCTGAGTTTGCTGCCCTCTGTCCCGCAGTCAGCCCCACTCTGTTCCCACTC CCTCTCCCCAGCCCCCTAGCTAGACCCCTCTCACCAGCACCCCTTTCCCTTCCCTGAGGGTCCCCCTCGC TGTCTTTGTCCCTCAGACATCCTCTTTCCTGGGCTCTCCTGCCAGGCCCTGCTGGAGGGACAGTTAAGGA GGAAATCGAATCAGCAGCGCCCACCCCTGCCCCCCTTCCTCTCCTCTTGTCAGACACCAGACGAGGTTTT TTCCTCTGGCTTCCCAGCTCTGAATGGGCTCATTCTTTTTCAGAGGCTCGGCCCCTCTCGAGCCTCCTCC CCAGGGCGTGAGTTCTGACCCCAGCTCCTCCCCCCATCCCCACTCCAGCCCCCTCTCCAGCTTGCTCCAC CCTCTCTACCGCCCACCGGGACTGGGCATTGTCTGCCAGTCCGGGTTTCTTCCTGGGATTTGGGATGCAG AGAGGATGGGTTTGCTTGGGCGGGGGGGTGGAGAGTGAAGGGGGGAAGCAGGATCTTTGTAGAGGGAGGG ACCTACAGTTACCTGGACTTCTTTCCTCTGTCTCCCCTCTTGGTACCCTTGACTGGGGCTCTTGAGGGTA ATGGGTGAAGCCAAATCTGCCATGGCTCAGTTCCCAGCTCAGCTCTGTGACCTTGGGAAAGTTCCTTTAG CTCGTGGAATCTCAAGGCTCAAGGTTCCTCTTCTGCAAAATGGGGAATGATAACACCTGCCTCCTCTGGA GTCTTGGGGACTCAGTGTTCTGAGGAACGTGGCTGTAGGTCAGAGTGGCACAGAGTAGGGTCCAATGAAG CATGGCGTCCACAGTAGCTTTCCTGACTGGACTAACCTTTCCGGACACAACAGCAGGGCAGGGGTGGGGC CTGGGGAGAAAGGACACCTCTAACCCTGATCCTAACATCCCGATGGCCTCTAAGGCTGCCTGCACACTCA TCCAGGTGCAAGCCCTCCAAGGTGTGGTGTGATGAACCAGTGACTCCTGGAGCCAGGTCAGCGCATCCTC TTCCCGCAGGGCTGTAAGCTGCAGGACTGAGAGGCAGGTTGACCAGGTCCTGGGCTGGATGATGGGGTGA GAGTAAGGGGTCAGTTTTGATACATGCCCAACTTTTCTCTCTAGCCCTAAGACATCCTGGGCAAATTGCT TACCTCAGTTCCCCTGATCCTCACCCTAACCCTAACACCAGCTCAAGAGAAAATAGGGATATTGATGGCC ATCCAGAAGGGCTGCTGTGTTCCATACACAGCAATATTTCTCGAATGTTTGTGACAGCGGTCCAAGGAAT AAGTTAATTTTACATTATCACTCTGGATACCTGTACAAAACTCCACCTTATCCTTACTATATGAATGTGC TAGGGTTGTTTTTTTGTTTTGTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTTGCCCAGGCT GGAGTACAATGGCGCGATCTTGGCTCACCGCAACCTCCGCTTCCCAGGTTCAAGCGATTCACCTGCCTCA GCCTTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCATGCCCGGCTAATTTTGTGTTTTTAGTAGAGA CAGGGTTTCTCCATGTTGGTCAGGCTGGTACCAAACTCCCGACCTCAGGTGATCCACCTGCCTTGGCCTC CCAAAGTGCTGCAATTACAGGCATGAGCCACCGCACCCAGCCGTGCTAGGGTCTTTTTCTGTTCAATTCC TTTCTCTCTCTTGCTCTCTTTCTTTCTTTCAATGGAGTCTTACTCTGTCACCCAGGCTGGAGTGCAGTGG CAAGATCTCAGCTCACTGCAACCTCTGCCCTCTGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTA GCTGGGATTACAGGTGCCTGCCACCACACCTAGTTAATTTTTGTACTTTTAGTAGAGATGGGGTTTTGTC ATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCTGCCTGTCTTGGCCTCCCAAAGTGCTGGGA TTACAGGCATGAGCCGCCATACTCGGCCAACTTTGTATTACTTTCTTAAAGAGAGTTTCCCAAATTATAT AAGCTTCAGGCCCCACAAAACCTAGATCTGCCCCAGTATAACTAAATCTGGGACCATTTATTGAGCAATT ATTATGTGCCAAGTATTGCGCTGAGTGCTTCCAGAGCATTATCTCCTTTAACCCCAGCATAGTATGTCAG ATGCTGTTTTACAGATGAGCCAACTGAGACCAGAGATGCTCAGTCACTTGCCCAAGGTGACATGACTGAT ATGGAATAGAGTCAAGATTTTTTTTTTTTTTTTTGACACGGAGTCTCACTCTGTCTCCCAGGCTGGAGTG CAGAGGCGCAATCTCAGCTCACTGCAAGCTCTGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCC TGAGTAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTGTATTTTTAGCAGAGACAGGG TTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTCGGCCTCCCAAAGT GCTGGAATTACAGGTGTGAGCCACCGCGACTGGCCAGATTCAAGATTTGAACCCAGGTCCTCTTGGTCCC AGAGGCCCCTGTTTCTCAACTCCCTAGGATGGCATAGCAACCTGTCCCACAAGAGGTGCCTGCTTTAAGT GTGCTCAGCACATGGAAGCAAGTTTAGAAATGCAAGTGTATACCTGTAAAGAGGTGTGGGAGATGGGGGG GAGGGAAGAGAGAAAGAGATGCTGGTGTCCTTCATTCTCCAGTCCCTGATAGGTGCCTTTGATCCCTTCT TGACCAGTATAGCTGCATTCTTGGCTGGGGCATTCCAACTAGAACTGCCAAATTTAGCACATAAAAATAA GGAGGCCCAGTTAAATTTGAATTTCAGATAAACAATGAATAATTTGTTAGTATAAATATGTCCCATGCAA TATCTTGTTGAAATTAAAAAAAAAAAAAAAAGTCTTCCTTCCATCCCCACCCCTACCACTAGGCCTAAGG AATAGGGTCAGGGGCTCCAAATAGAATGTGGTTGAGAAGTGGAATTAAGCAGGCTAATAGAAGGCAAGGG GCAAAGAAGAAACCTTGAATGCATTGGGTGCTGGGTGCCTCCTTAAATAAGCAAGAAGGGTGCATTTTGA AGAATTGAGATAGAAGTCTTTTTGGGCTGGGTGCAGTTGCTCGTGGTTGTAATTCCAGCACTTTGGGAGG CTGAGGCGGGAGGATCACCTGAGGTTGGGAGTTCAAGACCAGCCTCACCAACGTGGAGAAACCCTGTCTT TACTAAAAATACAAAAAATTAGCTGGTCATGGTGGCACATGCCTGTAATCCCAGCTGCTCGGGAGGCTGA GGCAGGAGAATCACTTGAACCAGGGAGGCAGAGGTTGTGGTGAGCAGAGATCGCGCCATTGCTCTCCAGC CTGGGCAACAAGAGCAAAAGTTCGTTTAAAAAAAAAAAAAAGTCCTTTCGATGTGACTGTCTCCTCCCAA ATTTGTAGACCCTCTTAAGATCATGCTTTTCAGATACTTCAAAGATTCCAGAAGATATGCCCCGGGGGTC CTGGAAGCCACAAGGTAAACACAACACATCCCCCTCCTTGACTATCAATTTTACTAGAGGATGTGGTGGG AAAACCATTATTTGATATTAAAACAAATAGGCTTGGGATGGAGTAGGATGCAAGCTCCCCAGGAAAGTTT AAGATAAAACCTGAGACTTAAAAGGGTGTTAAGAGTGGCAGCCTAGGGAATTTATCCCGGACTCCGGGGG AGGGGGCAGAGTCACCAGCCTCTGCATTTAGGGATTCTCCGAGGAAAAGTGTGAGAACGGCTGCAGGCAA CCCAGGCGTCCCGGCGCTAGGAGGGACGCACCCAGGCCTGCGCGAAGAGAGGGAGAAAGTGAAGCTGGGA GTTGCCACTCCCAGACTTGTTGGAATGCAGTTGGAGGGGGCGAGCTGGGAGCGCGCTTGCTCCCAATCAC AGGAGAAGGAGGAGGTGGAGGAGGAGGGCTGCTTGAGGAAGTATAAGAATGAAGTTGTGAAGCTGAGATT CCCCTCCATTGGGACCGGAGAAACCAGGGGAGCCCCCCGGGCAGCCGCGCGCCCCTTCCCACGGGGCCCT TTACTGCGCCGCGCGCCCGGCCCCCACCCCTCGCAGCACCCCGCGCCCCGCGCCCTCCCAGCCGGGTCCA GCCGGAGCCATGGGGCCGGAGCCGCAGTGAGCACCATGGAGCTGGCGGCCTTGTGCCGCTGGGGGCTCCT CCTCGCCCTCTTGCCCCCCGGAGCCGCGAGCACCCAAGGTGGGTCTGGTGTGGGGAGGGGACGGAGCAGC GGCGGGACCCTGCCCTGTGGATGCCCCGCCGAGGTCCCGCGGCCGGCGGGGCCAGAGGGGCCCGGACGAG CTCTCCTATCCCGAAGTTGTGGACAGTCGAGACGCTCAGGGCAGCCGGGCCCTGGGGCCCTCGGGCGGGA GGGGGCAGTTACACGGCAGCGGCTCGAGATGGCCCATCCAAGAGACTGGCGCTTTCCAGGCTCCGAGGGG CTCCGGGAACTTGTCAAAGAAGTTCTCTGAAATTGTTCAGAAAGTTTTCCCGCAAAGGGTGTATTGCGTA GAGCGCGCGCGCGCGTTTCCCCCCTTCTTGAGCCCCCTCAAGCTTTCTCAAAGCCTTTCCAGTTGGCAGC CTCCGCCTCCGGACTGGCCTGGGCTGGATTCCTTGGGGGGGTCCTCTGCCCTGCCCCTCCTCCAGCCCCT CCCCGCTCCCCTTCAGACGATTTTGGTTTGGTTGCTCCTGCTTCTGGCGGGGTCGGGTGTGTGTGTGTGT GGTGGAGTGGAGGGTGGCATAGCAACCTGTCCCAACCAGAGCCGGGGAGGAAAGGGTGGCCCGGAGGGTG GCCTCTTGCTGGGGTCTGGGTTGGGGGCGGGGGAGACGTTTGCTTTGAACAGATTCTTGGGGCCAGCTTA GGGACTGTGCTCTGTGACTTTTGGAGCGCGTGGACCATGGAGGGGTGGGGGTGGGTTTCTTGGGGTGTAA AGTGGGAGAGTTCCCAGAGAAGGAAGCTAAGAAATAAGGCCAGATGGGAGCCTAGGGAGGGCTGCGTTGT TCTGCTGCCTTTTCCTTGGTGCTGTGCGTGGGGAAGGGTGAGTGGGGGCAGTGTGTATCCTGACCCATCT GTCCACCTGTGTGCATTAATCATAAAAGCTAACATATAGCCTGGGCCAGGTATACTCTGCCAGGAACTGT TTGTGGTGTTTTGCATGCATTCTCCTTTAATCCTAGAACACCCCTATAGTGGAAGTTCTGCCAGCATTCT GGACTGAGTAGCAGTCCAGAGGTTGAGTAGCAGCTAGTAAGTGGTGGGGTCAAGATGGGACCCCAGGCAG TGCGACCCCCAACCATGCATTCGAAATCGCTATATGGATGAGTGCACCTGGAGCAATGAGGGACACTGCT CCCTGAGTCACTGGGCTGCAGGGGAGACAAAATGAAAGTGTTCTGGGAGTCGTGGGTGGTCTCCATAGGT CAGAGGGTCTGGGGAGGGAGTGGGTGTCATCGTGGCTGTGTGTTGCCCGAGGGGCCCTCTGTGAGTGAGT GCATGGCCGTGTTATCTCTGCAGGTCTACGCCAGGGTGTTCCTCAGTTGTGTGGTCTTTGTATTTGTGTG TCTGGGCTTTGTGTTGCCAAACAGCAGTCTCTCTGCTGACTTGGGGACACAGGCTGAACTCTGTCCTCTG CAGGAACTCCCTTAAGGTGCTGGGCCAGATCTGCCATAAACAGAGGGAGGTAGCCTTCTATGGCCACGCC TTCTTGCTGAGGAAGAAGGTTCCTCTCTTCCAGGGAGTACATCCTTGCCCTCCCTGTTTCCCAGACAAGC ATCTTCACCTCTCATCTTCTGATGAGAAGGGTGAGGCCATACTGAGCTGTCAGGCTGAGCTGCTGCCCTT CCTCACCTTGGGCTGGGAGTTGATCAGGGAATGGCAGTTGCTGCAGAGCTGGATTTGAGGGCTGGGTTCT CTGGATGGGGCCTCCTCATGTCCTCACCCCTCAACCTGCACTATTGATTGTGTTGTGCAGGAGTTAGTTA AAAAGTCATTGCACAGCCTGGGCAACAAGGCAAAACTCTGTACAAAAAATACAAAAATTAGTTGGATGTG ATTACACGTGCCTGTAGTCCCAGCTACTCCGGAGGCTGAGGCAGGAGGATCACCTGAGCCCAGGAAGTTG AGGCTTGCAGTGAGCTGTGATTGCAAATGCTCTCCAGCCTGGGTGACAGTGTGAGACTCCGTTTCAGAAA AAAAGTATACCACCCAGCTGCCTCCAGCACCCAGATTTTACCCAAGGGGTGAGGTCTGGGGCAGGAATGT GGGGGAAGGGGAGGCCTAGGGGGAGCCCCAGAGGGGTCAGGATTTTTCTGAAATCCTTTCTTAGAGGTAT GGGTTTTACAAATTGCAGCAAATACATCCTTTTAATCTTGCAGAACTCCTTCATATTTTAATTCCAGTAT GATTCTTCCAACAGCCTCCTCTCTTTACTATACTTGGGGAAAGTACTCATTTTATTTGTCAAGAAAAAAA CAATTGAAAAGATAGGGATCAAATGTAAAAAGAAAAAATACGTGGCATTCCAAAGTCAAACACAAAGCAT GTTTAATTTTCTCGTGGTTTGGGATTACCCATATTCCTGCTGTATGAACCTGTCTTGTCTTAACTTTTAA GAAATGTACGGTGTACTTCCTATATGCTAGGTTTTTATCCATGCTTTCATTTAATCTCTGTGACAGTCCT GTGAAGTAGGTGCACAGATGAGAAAATGGAAGTTCAGAGAAATGAAGCAACTTATCCAAGGCTCCCAGCT ACCCAGTAATGTCCAGGGAATTTTTGGACTCTGAAGAGGAGGCATTAAGAGGTGGTTAGAGTCTTATTCC AGCCAACAATAATGGGTTGAACAAAGCCTTAGGGGCAGGCAGGTGGCCAGATGGGAGGAGAAGCGCTCCT CTTGTTCAGGCGAATGACCTTTCCATCCACTTCTCTAGGCTGTAGAAAGTGGAGCTGAGCTGGGGGCCCT GAGGTTCCCTCTTGACTTCAGAGTCCTCTCCCTTCCTGTCCAGCCAATGCCTGTCTTCCTTTTGGGCCCT ACCAGCATGACAGGGGGCTGCGGGCAGGAGGGGACAGAGGCCACGTTGACACACAGGGCTGTGGGTGAGA GAGACAGCTGAAGTGTCAGCGTGAGGGGCCAGTGTGGGGCTGCGGCTGGGAGGGCTGGGGTGGGGCCCAG GGTAGTTGTGCCTGTCCTTGGGTGATGGAATGATCTGGAAAGAGATTCCTTCCCTGCCCTCCACCTGTGA GAAGCCCCTCTAGAGTGACATCTCCATCTTATGTTTGGCCACCCATCCTCCCCCTGGGAAGAGAGCCGAG GTGGGGTAAGGGATGTGTACTCTTTCAAGGAGTGGGAGAATTATTCTAGCGAATGTTTGTGTTGTCCCAG TTCTGTTTACAAAGCCTCGTCATGTTTACAGATGGCTGCGCAATTCATTACCTCATTTAACTCTCATGTA CCTCCTCTGAGGGAGTAAGAGCTGTTACAGCCAAGTTTAGGTCAGTAAATATTCACCAAGTTGCAGGTAC TGCAGGGCATAGAGATGAATCCGATTTAGCTTCTGCCCTGGAGGTCTGGGAACTTGCTCAAGATCACTCA GTGAGCAGCTGAGCTAGGGTTCTCAACTAAAGACCCTGGGCCCAGGCCCTGGTCTGATGTCAGGCCTGAT ACACCAGGTGTTTGTGGTCGGGGAATCCCAGTGTCACTTGAATGGGCTGTGACATTATGGGTCTGGGAGA GCTGAGCTTTGGGGACACAGGTCATTTTACTGTAGTATTCATGGAAACCAAGGGAAGTATTGGCTTTTCT GCTGTGAGCAAGAGGAGCAGCTGGGGCTGCAAGCTGGTGGGGAGGAGAGAACCCACCTGAGAGAAACCTC AGGACTGGGGTCAAGTCCTGACCACCAGAGTCCAGAGAGACATGAAGGACTGTGACCAGCTCTGAGCAGA GAGATGGATTCCATGACCTCAACTGGTCCCTTTTGTTCGGAGACTCGTGACTGGACTTCATTCATCCACT CATTCATTCATTCACTCAGCAGACACTTATCTAGCGCTCCCTGTGGCTGGTCCTGCCTCATACTGTCTTT GCTCTGGAGAATTGGAGGTTGGGGTTCCTGAGGGGCAGGGTCCTGGAGACAAGGACACTCCTGGGTAGAA TTAGGACCTACCCCCCAGGAAATCAACGGGGACCAGGTGCCGTGGCTCACACCTGTAATCCCAGCACTTT GGGAGGCCGAGACGGGCGGATCACAAGGTCAGCAGTTCAGGACCAGCCTGGCCAACATGGTGAAACCCGC CTCAACTAAAAATACAAAAATTAGCCAGGTGTGGTGTCAGGCACCCGTAATCCCAGCTACTGAGGAGGCT GAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCA GCCTGGCGACAGGGCGAGACTCCATCTCAAAAAAAGAAAACCAATGGGACAGGGCAGATATGGGGACAAT GGTAAGGAGATGGGAGAGTGGGAGGGAGGTGTCAGGAAGACCTTCTTGACTTCATGTAGGCTGGTGGGGG TGTTAGCCAGCAAGCCTCCAGTTCCCTGGGAACCGTTCTCAGGGTACCAATTTTACCACCTGTCTGCAAA CACTTTAAGATTCTTAATCAGACTCAAATTGGCCACAAATCAGGTAAACAAACTCACTAGTGGGGTGGGG CTACCACCCGTTCTGACCCTCCAGCCCAACCCAGCCCAGCCACCCTGCCCTCCGTAGAGCCTGTGGTGTT TATCGGTGGCATTGGGAGAATTAGTGTGTATTTATGTTGGCGTGGGGTGTGGGGTGGATTTGTGTGTGTG CAGTTAGGCCTAGTGGAAGGAATGTGGGATCTGAAGGCAGGCCAGCCTGAGTTCCAGTCCTGCCTGTTGC TCACAAGCTTTATGAGGCGAGAGCTAACCCCTGCCAGCCTCAGTTGTCTTCTTTGCAAGATGGAGGTTGC AGCCCCAGTCTCTGGAGCATGTTATGCAGATCCACCGAGAGTGCCTGCCAGGCACACAGTAGGTGCTCAG CTCAGTTACTGTGGCGGCCCCCACTCCCCATTGTTGTTGTTTTCCTATTGCCTGGCGGCCACAGCTGGTA TCCCTTGAAAAGGGCTACAGGGGGTGGAGTCGGACCCTGCCCCAGCCCTGTGGAGACCCTGGGCTTGGGC CAGGGCCTGGGGTCTGGGCCTGCAGACAGCTGTGTCTATAAAGCAGCTGAAGGGCTGAGGCCGGGGGAGG TCCTGGCAGCAGGGCGTTATTTTGGGCCTGGCCTGCCACCCCCAGCTCCTGTTTCTCTTGGGAGTCTGTT GGGGGAGGAAGTGTGGGGAAGAGGAGGGGGTGCAAGTGGGTGAGGCATGGAGTGGGGAGGCCTCCCTCAG GGACATGGACCCTTGAGTTCTATTTCTGTTCCTCCCTCCTGTTCCTCCCTCTTTGTCCTTATCTGCCTAG AGAGGTGGGAATAGAGGCCATTCTGAGTATCACTAGGAGACCACCAGTTTGTGGCCACTGGCCACTGGCC CAGGCAGGGAACCTGGGGGCTTGCCCTACCAGCCTCTCCCAGCAATCTGAAGGCAGGGGGTACCTCGTAT TACCCCCTAGGATTTGACCTTAGGCTCCAACTTGCTGGGAGAGCAGTGCCTCTGGTGTCAGACCCCAAGC CAGCCCTTGTGCTGTCCCTGAATCTGCATGTAGCCTGTGGGAGGCGGAGCAGTGACCGGCAGGAATTCTG GGCAGCTCAGGCACCTGTGGGCCTGAGGGTGCCCTCTGCCCCCACCCTTCCGATCTCCTGGGCAAGACAC GCCAGGTGATTCATCTCACCAGAGCAGAAAAACAAGTTCAACTGGGCACTTTAATCTCCCCTCACTGGCA GGCCTGGTGTGAGCTGCTACCCCGGCGCCCCTCACCAGGGGTGCTTTACCTCCTCTAGTATTCCTGACCT TAGTGGGCATTTCTGGTCTCAGGGATACCAGGCTGGGGTCCAAGTGGGCCAGGTGTGGCAGTTCAGCCCT ATGCCCCATGGCTGATGGCTCGCGCTGGGCAGGTATGCAGGGCTGACGTAGTGCCTTTGTGGCAGCAGTT TCGTGGCACACATTCTGCCAGCTGGTTCTGGAGTCTTGCCCTGAGGAGGTGGCCAGGGTGAGGGTGCCAG CGCAGGAACCTTTGGCGCATGCTTCACCCTGGCCTGGGATCTGCAGCCTGGGTCCAGATGCCCACAACTG GAATCTGACGCTCCTTTTCTCTTCATGGGGGACTCCCAGAGGTCTCTGCAATGACCAGAGCCCCGGTTGT CCCATGCCTCAGCTGCAACTCCAGCTGACCCTCCTTCCCCACTCTCTGGGTGGCATTACGGGGGTGTGGA TCCCTTGCCAAGAGGTTGGCATGTGGGTGTGCTGGAATGGCATAGGGAGAATGCACCGAGTTTGTTTGCT TGGGAGAGGGGCAGGGGGTATCCAGAAGATTCATGATTCGTCATCGCCTCTCTTGGGGGATTTTTACCCC TTTGCCCTGAGTTGTGCCTTTGGGACAAAGGAAGCCTTTCTTTGCCAGCCAACACCCTGTACTGGCGGGC GAGCTCCCCAGGGCTGGCACGCTGGGGCAGCCTCTGAATGCACAGGGTGGGCCTAGTCAGAAGAAGCCTT TCCCCTGAAATCCCTCTACTTCCCAAGCACGCAAGCTTTCTCCTGCTGTTAAACCTGCAGTGTGCAAGGG ACATGGGCGGAGGGGTCCTTCAGTCAGGCTTCTCCCTGTCTGAGGTGGCATGACTTGGAGTGAGTTTGGA TGGGGTGGCCAGGTCTGAGAAGGTCCCCCGCCAGTGTCCTCTGACCCATCTGCTCTCTCCTGCCAGTGTG CACCGGCACAGACATGAAGCTGCGGCTCCCTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCTC TACCAGGGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAATGCCAGCCTGTCCT TCCTGCAGGTGAGGCCCGTGGGCAACCCAGCCAGGCCCTGCCTCCAGCTGGGCTGAGCCCTCTGTTTACA GGTGGGTGGCAGAAGAAGGTGCCCTGCCCTTCTGTTTCCTCTCTTGTTGTGGTTTCTCAACCAGGAAGTC CTTTCTAACATCTAACCCCCATTCATTTTACTGCAGAATCAGTTGACTCTCTCTATAACGTGGCTGGCCG AGGTCATGTCTGGATGGGATGCGTCTGTGTTTCCGCTAAATCTTGTGCTCTCTTGCCAGCATGATCATGT CCCCTGTCCACCTGCTCCAGCCACTATCCCTCTCCCACTTACAGCAGAAGAAAGGGCTGGTGAGAAAGGT GGATTACAGGCCCACTTCTGCCACTGACGAGCCCTATGAATGTGGCCTACACCCCCTTAGCTTCACTGGG TCTCAGTTTCCCTATCTGTATATTGGGAGCAGTTGTGAAGCTCAGAAGAGAAATGTCTGTGAAAAGGTTA TGAACAGGAGGGAGAGTGGAAACCAACCTGCTGGATCGTGTCCACAGACCCTGGAATGGGGCCACATGCT TGGTTTGTCAAATTGCAGACGCCGGCCGGGTGCGATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGC CGAGGCGGACAGATCACTTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCT ACTGAAAATACAAAATTAGCCAGGCATGGTGGCACATGCCTATAATCCCAGCTACTTGGGAAGGCTGAGG CAGGAGAATCACTTGAACCTGGGAGACGGAGGTTGTGGTGAGCCTAGATCGTGCCATTGTACTCCAGCCT GGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAATTTGCAGACGCCATCCCATCCAGGCCTTTGCT TTCACTGATGAAGAAACTGAGATACAGAGAGGGCAGGGCACCTGTTCGGAGTTTATGAAATGCCCCCCCA CCATTATCTTTCTTGATCATATAAGAATCTGGTGAGGCAAGGTAGGGCGTGATCTTTATCTCTATTTTAT CGTTTTATTTAAGCGGGAACAGGACTGCTCAGTGGCTGGGGGCCTTGCCCAAGATCTCCAAGTACTGGGG AACCCCAGGGAGGCCCTGGGGGGTGGCAGTGTTCCTATTTCAGCCCCACTCTGCTTCCCCCTCCCAGGAT ATCCAGGAGGTGCAGGGCTACGTGCTCATCGCTCACAACCAAGTGAGGCAGGTCCCACTGCAGAGGCTGC GGATTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAATGGAGACCCGCT GAACAATACCACCCCTGTCACAGGGGCCTCCCCAGGAGGCCTGCGGGAGCTGCAGCTTCGAAGCCTCACA GGTGGCCTTCACCGTCATTGAAACCTTCTCTTGGTTATTCAGAGCTGACCAGGGCCACTGCTAACCAGGG GGAGGCTTTGTGTGCATTAGAAATGGTGTCCCTTCTGGGCAGACGCAGGCAGAGCCCGGGAAGACGCCCT CAGAAGATTGGAAAAAGATTCCCCTTCTTCCTGGGAAGTTGTAGCTTGCGTCAGCACATATAATTCAATC GTGAGAATGCAGGCTGGGTTTTTGCCCCCACTTGGCTGAGTGAAGTGTACAGTGAACAACCTATGTAACT ATTTGCTGGCCCTGGAGCCGACTCTGCCCCAGAGTCTGGGTGCCAGGTGCTTTGCCCGCATGGCCCATTT CAGTCACGCTGCAGTCCTGTCAGGAAAAAATCAGTGTTATTCTCATTCTACATATGAGAAAACTGAGGCT TGCAGATATAAGGGCCAAAAGTTACACAGCTAGTGAGTGATGGGGCTGAGTTTCAGACTCCACAGTCTCT TAACCACCAAGCAGCATGCCCAGAGTAGAGGTGAGAAGGAAGGAGAGAGCTGCGGTCCACATGAGCATCT GGACCTAGCATGGACAACTCACTCCTCCCTGGCTCTCGCTTTGTTCTTGTTGCGGGTGTGGTGGTGGTGG GACTCAAAGACGGTAAAGATAGCTTTCTCTCCTCCCTGGGGAATCTGGGGGTTGTTTAAAAGGCCTGCTC CTCTTTTAGAAGGCAGGAGGGCCCCAAGGGAAGCAGAAGGTGACAGAAGGGGAAAGGGTCCTCTGATCAT TGCTCACCCCACAGAGATCTTGAAAGGAGGGGTCTTGATCCAGCGGAACCCCCAGCTCTGCTACCAGGAC ACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGACACCAACCGCT CTCGGGCCTGTAAGCCATGCCCCTCCCTGCTGCCTCTTCTCTCAGACAGCCTGACCCCAGCCGCAAACTC CCAACTTACAACCCAGTGCCTGCCCGCCACTGCCCCAGCCGCCTACACCACCCATTTCCTCCCTCTCTGT CCCTCCTGCCATCTCCCTGTGCCTCTTCATCTCTGGGGTTCTCTGTCTTGTCTCCCTCTGCTTATAGGTT GTGCCTCTGGTTTGGGGGCCTCTCAGCCTGTCTGGGTCCCTCCCTTGCTGTGCAGTTGGCCTCGTGGCCT CTGCTGCTGTTTGTGCCTCTCTCTGTTACTAACCCGTCCTCTCGCTGTTAGACATCTCTCTCACTGCCTG TCTCTGGTTCTGTCCTCAGGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCTGGGGAGAGAGTT CTGAGGATTGTCAGAGCCGTGAGTCTCAGGGAGGCCTGGAGTCAGGGAAGGGGAGGGCTGGGGCCGGGTG GAATGCAGGTGTCATACAGGTGACATGGGAGGGGTGGGATAACAGGCTTGGGATGTCTCCCCTGGGCCAG GTAGTCTCCCTAGAAGGTGATGCTGATGAGGGTCTGGTGCCCAGGGCGCCACTCAGCCCTCATCCTGCCC TTTGCCCAACAGTGACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCCACTGCCCACTGA CTGCTGCCATGAGCAGTGTGCTGCCGGCTGCACGGGCCCCAAGCACTCTGACTGCCTGGTATGTGCCTCT GCTTTGTGCCCAATGTGCTCTACCCCCCAGGATGCAAGGGGTGGGCACCCTGCCTGGTACTGCCCTATTG CCCCTGGCACACCAGGGCAAAACAGCACAGTGAAAGCCAGCCACCTGTCCCCCCAGGCCTGCCTCCACTT CAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAACACAGACACGTTTGAGTCC ATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTGTGAGTGCCAGG GAGAAACACAGTTTTCTCATTTTGGTGGGGAGGTTTGTTTCTGTAAATGGGAGCATATGGGGAGCACTGT CTGCATCTTGCTTTGAGAGCTGGTCATGACAGTTCCTGCCGAGCTGCCTTGTTCTTTCAACAGCTGTGGA GCAGGTGGCAGTAAGGAGAGGCAGCTAAGAGCCCAGACTTGGGAGCCAGACTGCCTGGGTTTGAAACCCA GCTCTATCAATTAGTAGGCACGTGACCCTCTTGCTGTGCCTCAGTTTCCTCATCAGTAAAATGGGGGCAA GAATAGTCCCAACTGCATAAGATGGTTATAACATTTGAAAGAGTTAATATTTGTAAAGCTCTTAGAACGG TGCCTGGTATGTACTAAGTGCTCCTAAATGTTAGCTTTTATTCTATAGCCTGGTGAGGTCAGTTTTACCT TTCGTTTTGTTTTTGAGACCGAATTTAGTTAGCTCTATCGCAGTGGCGCGATCTCGGCTCACTGCAACCT CCGCCTCCCAGGTTCGTGCTATTCTCGTGTCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCCACCAC CATGCCTCGCTAAATTTTGTATTTTTAGTAGAGACAGGGTTTCACCACGTTGGCCAGACTGGTCTCGAAC TCCTGACTTCAGGCGATCCACCTGCCTCGGCCTCTGAAAGTGCTGGGATTACAGGCGTGAGCCACTGCAC CCGGACTTTTTTTTTTTTGGCAGAGTCTCGCTCCATTGCCCAGGCTGGAGTGCAGTGGTGCAATTTTGGC TCACTGCAACCTCTGCCTTCCGCATTCAAGCAATTCTTGTGCCTCAGACTCTTGAGTAGGTGGAACTACA GGCATGCACCACCATGGCTGGGTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACTATGTTGGCCAAG CTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGTCTCCCAAAGTGCTGGGATTACAGGCAT GAGCCATCGTGCCTGGCCTAGCTCAGTTTTATTTAACAGATCACCTATTTACTGATGGGCGTTTATGGAC TGGGCTCAGACCTGGGGAACCTCTTTCCTCCTCTCACAGGAACAGGAGTGGGCCTTCAGATCCTGGCTGA CTGTGTTAGGGAGAGGACAAAATGTAGAGCCAGACCATTTGGGTTCAAATCCTCGCTCCTCCACTCACTA GCACAATGACCTTGAATAATTTACAGAACTCTCTGCTTTGGTCTCCCTTTTTGCAAAATGGGAATCTCAC AGTGCTGATCCCGTCTGGTTGTTGTGAGGGGTAAATGGATGTCAGGTGCTGATGCGTGGTAGGGCATTTA AGTATTGGTTGATATTATTCTTCTTGTGCCTGGGCACGGTAATGCTGCTCATGGTGGTGCACGAAGGGCC AGGGTATGTGGCTACATGTTCCTGATCTCCTTAGACAACTACCTTTCTACGGACGTGGGATCCTGCACCC TCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGGAACACAGCGGTGTGAGAAGTGCAGCAA GCCCTGTGCCCGAGGTACCCACTCACTGCCCCCGAGGCCAGCTGCAGTTCCTGTCCCTCTGCGCATGCAG CCTGGCCCAGCCCACCCTGTCCTATCCTTCCTCAGACCCTCTTGGGACCTAGTCTCTGCCTTCTACTCTC TACCCCTGGCCCCCCTCAGCCCTACAAGTGTCCCTATATCCCCTGTCAGTGTGGGGAGGGGCCCGGACCC TGATGCTCATGTGGCTGTTGACCTGTCCCGGTATGAAGGCTGAGACGGCCCCTTCCCCACCCACCCCCAC CTCCTCAGTGTGCTATGGTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCAGTGCCAATATC CAGGAGTTTGCTGGCTGCAAGAAGATCTTTGGGAGCCTGGCATTTCTGCCGGAGAGCTTTGATGGGTAAG AGTGGGCACGATGACCTGAGACAGTGTCAGGGCAGACAGAGTCCTGAGGATCCAGATGTGGCAGCATCTC TTGGGGATGGCAGGAGACAGAAGTGGGGGGATCAAGAATGCAAAGAAAGCAGATGGGAGACCAGAGGAGC AGGGCCTTTGGTGGGTGGGGGTGATTATTTTTGTAAATGACATGCTATCCGTGAACAAGGACTTGTATGG AGGTCAGACCATCTAGATAAAGTAAAATTCCCTTTGAGTTCATAGCAGCTTTATTCAAAATATCCCCAAA TTGGAAATAACTCAAATGTGCATCACTAGGTGAAGGAATAAACAAGTGGCAGTGTATCCATTTGGTGAAG TTCTACTTAGCAACCAAAGGAAATGAACTACCGATACAACATAAATGAATCTCAGAAACATTACATTGAG CAAAAGAAGCCAGAGACAAGATTCCATACTGTCTGATCCCCTTTATGTGAGGCTCTGAACCGAAAAAACC ACTCTGTGGTGGGAGAGATCAGAACGGTGGTTGCCCCAGGGTGGGGGGCTTCAAAAGGGAGGCACACAAG GACATTTCTGGGGTAATAGAAATGCTCTGTATAGTGATTGGGGTAGTGGATACATGAGCGAATCCATTTG TCAAAACTCATCAAACTGTGTGATAAGAGTCTGTGCATTTTATTTATTTCATTTTATTTTTTGAGATAGA GTCTCACTCTGTCAGCAGGCTGGAGTGCAGTGGTACGATCTTGGCTCACTGCAACCTCTGCCTCCTGGAT TCAAGCAATTCTCCTGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCATGCCCAGCTAA TTTTTGTATTTTTAATAGAGATGGGGTTTCACCATGTTGGCAAGGATGGTCTCGATCTCTTGACGTCGTG ATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCCGGTGCATTTTATT GTATATAAGTTATACTTCAATAAGAAATGAATTGGGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGC ACTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGA AACCCCATCTCTACTAAAAAATATAAAAAATTAGCCAGGCTTCCTGGCATGCGCCTATCATCCCAGCTAC TTGGGAGGCTGAGGCAGGAGAATTGCATGAACTCGGGAGGTGGAGGTTGTAGTGAGCTGAGATTTCGCTA TTGCACTCCAGCCTGGGCGACAGAGTGAGACCCTGTCTCAAAAAGAAAAAAAAAAAAAAGGGTCAGGCGC CGTGGTGCACACCTGTAATCCCAGCACTTTGGGAGGCTGAAGCAGGAAGATTGCTTGAGCCCAGGAATTC AAGAACAGCGTGGGCAACATAGTGAGATCCCATCTCTACAAAAAAACACAAAAAATTAGCCGGGCATGGT GGTACGCACCTGTAGTCTCAGCTACTAGGGAGACTGAGGTGGGAGAATCACCTGAGCCTGGGAGGTGGAG GTTGCAGTGGGTTGAAATCATGTCACTGTACTCCAGCCTGGGTGACAGAATGAGACCCTGTCTCAAAAAA AAAAAAAAAAAAAAAATTCCCTTTCACACTTCCTTTACCTCCACTCCCCTTTCCAGAGGGGGCCATGGTT AACAGTGTGTGTGTTCACCTAGACCGTTTATGCATCTGTAGACACACACACAGTGAAGTGTGGTTTTCGT CGTTTTGGTGGGGAGGTTGGTTTCTGTAAATGGGAACATATAGGGAGCACTGTCTGCACCTTGCTTTGAG AGCCGGTCATGACAGTTCCCATTGAACTGCCTTGTTCTTTCAATAGCTGCAGAGCAGGTGGCGGCAAGGA GAGGCAGCTAAGAGCCCAGACTTGGGAGCCAGACTGCCTGGGTTTGAAACCCGGCTCTACCACTTACTAG GCATGTGACCCTTGTGCTGTGCCTCAGTTTCTTCATCTGTAAAGTGGGGGCAAGAACAGTCCCAACTTCA TAAGATGGTTATACCACCATGCCTGGCCAGATGATTATAAAGTTTGAATGAGTTAATATTTGTAAAGCTC TTAGAACAGTGCCTGGCAGATACTAGGTGCTCCTAAATGTTGGTTTTTATTATGTGGCTGGGTGGCTCGG GGTTTTATTTAACAGCTCCCCTATTTACTAATAGACATTTAGATCATGTTCCATTTTCACTCTTACAAAC AGTTCCACTTTGTGTGTGGCTCTGGGAACATGGGCCAGTGTCTCCCTAGGCCACATTCCTAGAAATAAGA TTTCTTTTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTTTATCGCCAGGCTGGTGTGCAGTAGTGTG ATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCTCGAGTAACTG GGACTATAGGCGCGCGGCACCACACCCAGCTAATTTTTGTATTTGTAGTAGAGATGGGGTTTCACCATGT TGGCCAGGATGGTCTCCATCTCTTGACTTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTAC AGGCGTGAGCCACTGAGCCCAGGCAGAAATAAGATTTCTAGATCAAAGGATATAAATACTGTTTTGATAG ATGTTGCCGAACTAAGGCCTGGGCTTTGAAGCCCAGGATGGGAACAGCTGGGCTCGATGGGCAAAGGGTT TGAGTGAAGGCATTCATGGTGGGGAGTGGCTGGCATGGCCAGTGCTGGGAGTGATGTCCACCCTGTTCCT GGCCCTGCTGACTCCTCTCCTGACCCCTCCAGGGACCCAGCCTCCAACACTGCCCCGCTCCAGCCAGAGC AGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGTGGGCTCTGTCTCTGCATCCTGTTCTGCAGGGG CTGGGAGTCCTTGTCCTGTCCCCACTCCTTTAATCTCACCCTCTGCCTGCAGGTTACCTATACATCTCAG CATGGCCGGACAGCCTGCCTGACCTCAGCGTCTTCCAGAACCTGCAAGTAATCCGGGGACGAATTCTGCA CAAGTGAGCACTGAGAAAGAGGGGGCCTGATGGGGAGGAGTCCCAGGGAGGAGTCCCTGTGGGAAGCTTT GGGCCTGAGGGAGTACTCCTGTAGCAGTAACCTTTCCATGAAAGTCTGCAGAGTGTGCTGGGGATGGAGG AAGATGAGAATAGCCTTTGCTGACCGGGAAGGGGTCCGTGGTAAGGTGCCCACCTTTCTCCCATAGTGGC GCCTACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCTGCGCTCACTGAGGGAACTGGGCA GTGGACTGGCCCTCATCCACCATAACACCCACCTCTGCTTCGTGCACACGGTGCCCTGGGACCAGCTCTT TCGGAACCCGCACCAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGGTAAGACAGGGAGC CCAGTGTGCGCACTCCCCATCTGCCAGCACACAGCAGTGCCCAGGGGGCCCTGGCAGCAGCGTTCTTGGA CTTGTGCAGACTGCCCGTCTCTGTGCACCCTTCTTGACTCAGCACAGCTCTGGCTGGCTTGGCCTCTTGG CATGGCTTCTCTAGCTGGGTCCTACCTGCCTTGGCATCCTTCCCTCCCCCTCTGTTTCTGAAATCTCAGA ACTCTTCCTCTCCCTACATCGGCCCCACCTGTCCCCACCCCTCCAGCCCACAGCCATGCCCACAGCCAGT TCCCTGGTTCACTTGGACCTGGGGCCTCCCCTAAAAGTCCCCTGCGGTCCCTTCCTCCTCACTGCAGTGG GCGAGGGCCTGGCCTGCCACCAGCTGTGCGCCCGAGGGCACTGCTGGGGTCCAGGGCCCACCCAGTGTGT CAACTGCAGCCAGTTCCTTCGGGGCCAGGAGTGCGTGGAGGAATGCCGAGTACTGCAGGGGTATGAGGGG CGGAGGAGAGGGTGGCTGGAGGGGTGCATGGGGCTCCTCTCAGACCCCCTCACCACTGTCCCTTCTCTCA GGCTCCCCAGGGAGTATGTGAATGCCAGGCACTGTTTGCCGTGCCACCCTGAGTGTCAGCCCCAGAATGG CTCAGTGACCTGTTTTGGACCGGTGAGCTGCTGGCGGGCTCAGAGCTGGGTGGAGGGGGGCAGCGAGGGG GATTGCCAGGGACTTGGCAGGATGGCGAGATGCAGTAGGGTGTGCTATCTGGTAAAATATCCCTGGAGAG GGCTCAGCGCTCAGACCTGAACAGCAACAGAGTGGCAGAAAAGGGGCCTGGGGGACACTGGGGCCCTTCA GACTATGAAAAGGTTCTAAGGAGGTCTGTGTTGGTGGCTGTGACTGTGGCTGTGCTAGGGTGGTGAGCCC TGTGGGCTCAGGCGTCAGACTACCTGGATTCAGACCCAGCTCCTGCTTCCAACCTTGGTTTTTTATTCCT AAAATGGGTATTGTAATAATACCTACCTTGCTGGGGTGTGGCAAGAATGAAATTAAACAGGGCTTGGCAC AGTGAAGCACGGGAAAGGCTTTCTACAGAGCAGTGACTGTTGTTACTCGCTGTTACACCTTAGGTAATGC GTTTTCCTCTCTGGGTGCCTCCCATTTTCTGGCTCAAGTCCCTGCCCAGGATCAAGCTTGGAGGAGGGCC CCGAGGGAGGGGCCACAGAGACTGGGTGAAGAGCAAGGGTGTTTGTCCCAGGAGCATGGCGAAAATTGCT GCTGGGTGGCCTTGGGAAGCACAAAGGGGACCCAACTAAGGGCCTGATCCTACTGCCCTGGGGGTGTCAG TGCCAGCCCCCCACAAATCTTTTCTGCCCCCCCCAGGAGGCTGACCAGTGTGTGGCCTGTGCCCACTATA AGGACCCTCCCTTCTGCGTGGCCCGCTGCCCCAGCGGTGTGAAACCTGACCTCTCCTACATGCCCATCTG GAAGTTTCCAGATGAGGAGGGCGCATGCCAGCCTTGCCCCATCAACTGCACCCACTCGTGAGTCCAACGG TCTTTTCTGCAGAAAGGAGGACTTTCCTTTCAGGGGTCTTTCTGGGGCTCTTACTATAAAAGGGGACCAA CTCTCCCTTTGTCATATCTTGTTTCTGATGACAAAAATAACACATTGTTAAAATTGTAAAATTAAAACAT GAAATATAAATTAATGCCCTAGCAGTTCTATCCCCACTGTTAATAATTTGAAATATTTTTCCTCTAGTTA TTTTTGTCTGTGCACATTCTAATATGTATATATAAGTTAACATATATTAATATTATTCTCCAGTTATTTT TATCTGTGCACATTTTAACACACACACACACACACACACACACACACATATGTATTTTTAGACGGAGTTT CACTCTGTCGCCCAGGCTGGAGTGCAGTAGTACAATCTTGGCTCACTGCAGCCTCCACCTCCTGGGTTTA AGCAATTCTCCTGCTTCCGCCTCCTGAGTAGCTGGGATTACGGGAACGTGCTACCTTGCCTGGCTAATTT TTGTATTTTTAGTACATAGGATTTCACCATGTTGGCCAGGCTGGTCTCGAACCCCTGACCTCAGGTGATC TGCCAGCCTCGGTCCCCCAAAGTGTTGGGATTACAGCGGTGAGCCACCATGCCCAGTCATATATTTCTTT TTAACAAATAGAATCATAGATCATACATATTGTTTGCAAATTGCTTTTTCTCACTTTCCAGAACCTTGAA ATGTTTTTCCATGTTCTAACATGGTGATCTACCTTATTCTTTTAATTTTTCTTATTTAGTTGTCTTTACA CATGAAACACATGAATACATCCTTGTGATAAACATTTTCAGTAACATAAAAGTATAAATGTTACAAAGCC AACGTGCCCTTTCACTCAACTCCCTGTCCACCCAGTCTCTCCTGTCTGCTGGGAGAACCACCGCATTGAC TTGTGTGTTCACCCTTCCAGGCTCTTTTCTGCACACTTATATAGACATACTACATTTATATTAGGTCGAG TCAAATAAGATTGCTGTTTGTGTAAACCAAAAAGTGTCAAGAGCCTGGGCGCAGTGACTCACACCTGTAA TCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTTGAGATCAGGAGTTCGAGACCAATCTGGCCAAC ATAGCGAGACCCCGTCTCTACTAAAAATACAAAAACTAGCCAGGTGTGGTGATGCTGTTCTGCACTTTGC TTTCCCCCCGACTTGAGGTATCCTTTCTTGTGAGTACAGACGGATCTACCACCTTTATTTTTTTTTTAAT TACTCAACCTGTAACATGGATGTAATTTCACTTTGTTTTTGAGGGATATTGAGCTTGTTTCCCTGTTTTT GCAGTTTATTGCAATTGAGCTCCACACACAAGTGAGCCCTCTTTTGTATGCCCCCTAGTGGGAATACAGT GCTGGCAATGTTTATCACAAGGATATATTCATGCATTTCAATTTAAAGACAACTAAATGAGAAAAATTAA AAGAATATGGATCCAGGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAG GCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAA TACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTATTTGAGAGGTTGAGACAGGAGAA TTGCTTGAACCTGGGCAGCGGAGGTTGCAGTGAGACGAGATTGCACCAGTGCACTCCAACCTGGGCAACA CAGTGCAACTCCTTCTCAAGAAAAAAAAGAAAAAAAAAAAGAATATGGGTCCAGATCCATATGGATCCTA GATCCAGATCACGGTGTTAGAACATGGAAAAACATTGCAAGATTCTGCTAAGTGAAAAAAGCATTTGCAA ACAGTATGTACAGTCTATATTCAGAGGAGGAACTGCTGGGTCATAGATGATATTTCATAGGTATTGCCAA ACCGTTCTCTGGAGAAGTGGTATGGGTTTACCCTGGGATTCTTCTATGGAGGGAATAGTTGAGCTCCCGG GCTTGCTCTTCTGGGTGCCCCTCCCCGCTTCCTATCCACCACAAGGAGCTGCAGGGGAGCGGGGCATGCC GGTTCCTTGGCTGGAGAAGGAGTCTCCTTGTGAGGTGGTAGAAGGAGCACTGACGGCCTTGAGCCCAGTT TCTGCCTTTGTCAAATGGGGATAATGACCCAGCCACACCCCTCCCAGGGTTGTTGTGAGGCTGGAAAGGT GGTTCCCAAGAGGGTGGTTCCCAGAATTGTTGATGAGACTGTTTCTCCTGCAGCTGTGTGGACCTGGATG ACAAGGGCTGCCCCGCCGAGCAGAGAGCCAGGTTGGCCTGGACCCCAGGATGTACCCTTCATTGCCCTTC ACTCCCCCACTGGATGCTGGGTGGTCACTGCTGTAGGGAGGGGACCCCCTGACATATGTCCCTTCCCACC CACTCTTCCACTGTGGAACCTCCTGTCATTTTCCACTTCACCAAGTGACAGAGGACCTGCTCAGATGCTG AGGGGAGGGGACTGCAAGGAAAGATGGCTAGGAAACCCAGTCCCTCCACACCCTAGAGTAACTTGATGCC TTGTGAGGGACACAGGCAAAGTTCAATTCCTTGGAAGTCAAGGGAGACTGAGAAGAGTACAGCTGCAGCA CTGAGGGAGTGATGAATTCTTAACTGGGGATGGTGGGAGGCTTCGAGTGGGAGGTGGCATTTGAGCTAGG CTTTGAGAGAGGAGCAGGTATTGCACTTGCATTTAGGTAGAAAGCATTGGGGTGCAAGGTGACACTGGAG GGGGAGGCATCAGGAAATCCAGGATGTCTTCAAAGTTCTGGTGTCGGGGGCTGTTGAGTAAGCACAGGAA TAAGGGGGTCAAGTTAGAGTCAGGGTGGGGTCTGACCTGGATGCCATAGGACCTGATCCCCAAGCCACAG GGTGGGACTTGACTGGGCAGTGGGGACCTTTGGAAAGGACTTTGGGGAGAAAAACAGACTGGAGTCTGTC TTAGGCGATCATCGGTCCGTGAAATGAGCATGTGTTACAGGCTTGGTATGTACCAGACCCTGTGCTAAGC AAGGGGGTATGGAGAGGAGAGGGTGACAAGAATATTGGATCAACACCCGGGAGCTCCATCTATCCCAGGA TGCACTATCTTTTTTTTATTTTTTTGAGACGGAGTCTCACTCTGCCTGCAGGCTGGAGTGCAGTGGCTCC ATCTCGGTTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGCTTCTTGTGCCTCAGCCTCCCAAGTAGCTG GGATTACAGGCACATGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGT TGGCCAGGATGGTCTCGATCTCTTGACCTCAAGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTAC AGACATGAGCCACCGTGCCCAGCCAGATACGCTATCTTTTTATTGAGTGATTGAGACAGGGTCTTGCTCT CTTGTCCAGTCTTGAATGTGGTGGTGTAATCACAGGCTCACTGCAGCCTTGACCTCCTGGGCTCAAGTTA CCCTTCTGCAGTAGCTGGGACTATAGGAGCGTGCCACCACGCCTGGGTAATTTAAAAAATTTTTTTTGTA TAGACAGGGTCTCACTATGTTGCCCGAGCTGGTCTCAAACTCGTGGGCTCAAGTGATCCTCCAGTTTTGG CCTCCCAAAATGTTGGGATCACAGGAGTGAGCCACCACTCCTGGCGATGAGCCAAGTCTTTTTTTTTTTT TTTTTTTTTTGATATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAATGACACGATCTTGGCTCACTG CAACCTCTGCCTCCCAGGTTCAAGCAGTTCAAGCAATCCTCCTGTCTCAGCCCCCCAGTAGCTGGGATTA CAGGCATGCGCTACCACGTCCGGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTTGCCATGTTGGCCA GGCTGGTCTTGAACTGCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGT GTGAGCCATCGTGCCTGGCGGAGCCGAGTCTTAAAAGATGACCCTGTGGAGAAATGGTGGTCCAGGCTGA AGGGACAGCCTATGCAAACACTGGGAGGTGTGGAAAATCATGACCTGTGGGTGGAAATTTTGGCTAGAAC ATCAAAATCATCAGGTGTACATTCCTGTACCCATGCAGCAGTCAGAATCTCTGGGGGTGGGGCCCCAAAA TTGTATGCATACAGACTGTGTGCTGATTTGTGATATTACTTAGGATTTTTTGACTTTACAATGGTGGAAA AGCAATAATATACATTCAGTATAAACCGTACTTTGAATACCCATACAGCCATTCTGTTTTTCACTTTTAT TTTTATTTATTTATTTATTTATTATTTATTTTGAGATGTCATTTTGCTGTTGTTACCCAGGCTGGAGTGC AATGGCGCAGTCTTGGCTCACCGCAACCTCCACCTCTCAGGTTCAAACGATTCTCCTGCTTCAGCCTCCA GAGTGGCTGGGATTACAGGCAGGCACCACCACACCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTT CTCCATGTTAGTCAGGCTGGTCTCGAACTCGAGAGCTCAGGTGATCTGCCCATCTCAGCCTCAAGCCACC ATGCCCAGCCCTACTTTCAGTATTCAATAAATTACATAGCCAGGCACCGTGGCTCACACCTGTAATCCCA GCACTTTAGGAGGCCAAGGTGGGAGGATCCTTTGAGGCCAGAAGCTCGAGACCAGCCTGGGCAACATAGT GAGACCCCATTTCTACAAAAAATAAAAAAACTAGCTGAGTGTGGTGGCGTGTGTCTGTAGTCCCAGCTAC TTGGGCAGCTGAGGTGGAAAGACTGCTTGAGCCCAGAGGTCAGGGCTGCAGTGGGCCATGATCTCACCAC TGCACTCAGCCTGGGCAACACAGCAAGGCCCTGTCTCAAAAATAAATAAATAAATAACACAAACTTATTT AACAGTTTACTATAAAATAGGCTTTGTGTCAGATGATTCTGCCCAACTGTAAGCTGCTGGCAGTGTAAAT GTTCTGAGCACGTGTAAGCCAGGCTAGGTGTCTTAAATGCATTTTCAGTTTCAACTTAGAATTGGTTTAT CAGGACGTAGCCCCTTGGTGTTGAGGGGCATGTGTATTAACAGTCTCCTTAGTGACTTTTTTTTTTTTGA GATGGAGTCTTGCACTGGCCGTAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTTGTCTCCCGGGT TCAAGCGATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGATTACAGGCACCCACACCACGCCCAGCTAAT TTTTGTGTGTGTGTATTTTTAGTAGAGACGGGGGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCTG ACCTTGTGATCTGCCCACCTCAGACTCTCAAAGTGCTAGGATTCCAGGCATGAGCCACCGCGCCCAGAGT CCTTAGTGATTTTTACACCATGAATTGTTGAAGCCCTAAGCCAGAGCCAAGGGCAAGAGTATAGAGAATC TGGAGATGCGGAGAGGGTTCTGATTGCCTACAAGGAGTTTGGACTTTATTGTGGAGGCAGCGGGGAGCCA AGGCAGGTTTTAGAGTAGGAGAGGGTCCAAGCCTGTGGGTCACCCTTCCGACTTCCCTTTCCGAATGCCA AACACCTTCATGTCCCCCGTGGGCCCCCTTTGTCCCTCCCACCCCAAACTAGCCCTCAATCCCTGACCCT GGCTTCCGCCCCCAGCCCTCTGACGTCCATCATCTCTGCGGTGGTTGGCATTCTGCTGGTCGTGGTCTTG GGGGTGGTCTTTGGGATCCTCATCAAGCGACGGCAGCAGAAGATCCGGAAGTACACGATGCGGAGACTGC TGCAGGAAACGGAGGTGAGGCGGGGTGAAGTCCTCCCAGCCCGCGTGGGGTCTGCACCGGCCCCCGGCAC TGACCCACCACCCCCTCACCCCAGCTGGTGGAGCCGCTGACACCTAGCGGAGCGATGCCCAACCAGGCGC AGATGCGGATCCTGAAAGAGACGGAGCTGAGGAAGGTGAAGGTGCTTGGATCTGGCGCTTTTGGCACAGT CTACAAGGTCAGGGCCAGGTCCTGGGGTGGGCGGCCCCAGAGGATGGGGGCGGTGCCTGGAGGGGTGTGG TCGGCAGTTCTGATGGGAGGGGCAAGAGCTGGAGGCAGTGTTTGGGGGAGGGCAGTTACAGCGGAGAAGG GAGCGGGGCCAAGCCCTAGGGTGGTGAAGGATGTTTGGAGGACAAGTAATGATCTCCTGGAAGGCAGGTA GGATCCAGCCCACGCTCTTCTCACTCATATCCTCCTCTTTCTGCCCAGGGCATCTGGATCCCTGATGGGG AGAATGTGAAAATTCCAGTGGCCATCAAAGTGTTGAGGGAAAACACATCCCCCAAAGCCAACAAAGAAAT CTTAGACGTAAGCCCCTCCACCCTCTCCTGCTAGGAGGACAGGAAGGACCCCATGGCTGCAGGTCTGGGC TCTGGTCTCTCTTCATTGGGGTTTGGGGAGATATGACTCCCGCAAACCTAGACTATTTTTTTGGAGACGG AGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTTATCTCGGCTCACTGCAACCTCCACCTCCTGG ACTCAAGCGATTTTCATGCCTCAGGCTCCTGAGTAGCTGGGATTACAAGCGCCCGCTAATTTTTTTTTTT TTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTAGAGTGAAATGGTGCGGTCTCAGCTCAGCCTCCCA GGTTAAAGCGATTCTTCTCCCTCAGTCTCCTGAGTAGCTGGGATTACAGGCGCGAGCCACCACGCCCGGC TAATTTTTGTATTTTTAGTAGAGATGGGATTTCACCATGTTGGCCAGGTTGGTGTCAAACTCCTGACCTC ATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCTAATCT TTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGTCCAGGCTGGTACTTTGAGCCTTCACAGGCTGTG GGCCATGGCTGTGGTTTGTGATGGTTGGGAGGCTGTGTGGTGTTTGGGGGTGTGTGGTCTCCCATACCCT CTCAGCGTACCCTTGTCCCCAGGAAGCATACGTGATGGCTGGTGTGGGCTCCCCATATGTCTCCCGCCTT CTGGGCATCTGCCTGACATCCACGGTGCAGCTGGTGACACAGCTTATGCCCTATGGCTGCCTCTTAGACC ATGTCCGGGAAAACCGCGGACGCCTGGGCTCCCAGGACCTGCTGAACTGGTGTATGCAGATTGCCAAGGT ATGCACCTGGGCTCTTTGCAGGTCTCTCCGGAGCAAACCCCTATGTCCACAAGGGGCTAGGATGGGGACT CTTGCTGGGCATGTGGCCAGGCCCAGGCCCTCCCAGAAGGTCTACATGGGTGCTTCCCATTCCAGGGGAT GAGCTACCTGGAGGATGTGCGGCTCGTACACAGGGACTTGGCCGCTCGGAACGTGCTGGTCAAGAGTCCC AACCATGTCAAAATTACAGACTTCGGGCTGGCTCGGCTGCTGGACATTGACGAGACAGAGTACCATGCAG ATGGGGGCAAGGTTAGGTGAAGGACCAAGGAGCAGAGGAGGCTGGGTGGAGTGGTGTCTAGCCCATGGGA GAACTCTGAGTGGCCACCTCCCCACAACACACAGTTGGAGGACTTCCTCTTCTGCCCTCCCAGGTGCCCA TCAAGTGGATGGCGCTGGAGTCCATTCTCCGCCGGCGGTTCACCCACCAGAGTGATGTGTGGAGTTATGG TGTGTGATGGGGGGTGTTGGGAGGGGTGGGTGAGGAGCCATGGCTGGAGGGAGGATGAGAGCTGGGATGG GGAGAATTACGGGGCCACCTCAGCATGTGAAGGGAGGGAAGGGGCTGCCTGTGCCCCACCTTGCAGGGTC TGTGCACTTCCCAGGATTAGGGAAAGACCGGGTAGGGTCTGTCTCCTGGCATCACATCTCCCCCTGCTAC CTGCCATGATGCTAGACTCCTGAGCAGAACCTCTGGCTCAGTACACTAAAGCTCCCTCTGGCCCTCCCAC TCCTGACCCTGTCTCTGCCTTAGGTGTGACTGTGTGGGAGCTGATGACTTTTGGGGCCAAACCTTACGAT GGGATCCCAGCCCGGGAGATCCCTGACCTGCTGGAAAAGGGGGAGCGGCTGCCCCAGCCCCCCATCTGCA CCATTGATGTCTACATGATCATGGTCAAATGTGCGTGGCTGAGCTGTGCTGGCTGCCTGGAGGAGGGTGG GAGGTCCTGGGTGGAGGAGCCCACAAGGGGCATGAAAGGGGACCAGGATGTATGTAGACCCAGGAGCCCT AGTATGTTAGGAGCCTCAAAACCTTCTTGTATCCCTTTTACAGTCAAAGTCCAAAGCCACTCTTGAGGAA CACTCTTGTACAAAATTAAGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGTACTTTTGGAGGCTGAGG TGGGAGGATCCCTTGAAGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGTGAGATCCTATCTCTACAAA AAATAAAAAAATTATCTGGGTGTGGTGGTGTGTGCCAGTAGTCCCAGCTACTCAGGAGAGGCTGAGGCAG GAAGATCACTTGAGCCTAGTTTAAGGTTGCAGTAAGCTATGATTGCACCACTGAAATCCAGCCTGGGTGA CAGAGCGAAACCTCATCTCAAAAAAATAAAAAAGCAAACAAAAAGAAAAAAAAAATTAAAAGGGAAACTA GAAGAGATGCCAAAGGTTCTGGCTGAAGACCCCAGAGTCTGGTGCTACTTCTCTACCACCTGAGGGCTTT GGGCTGTCCCTTGGGACTGTCTAGACCAGACTGGAGGGGGAGTGGGAGGGGAGAGGCAGCAAGCACACAG GGCCTGGGACTAGCATGCTGACCTCCCTCCTGCCCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGA TTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGGTAC TGGGCCTCTGTGCCCCATCCCTGCCTGTGGCTAAGAGCACCCTCCTGCAGAGGGTGGGAAGGAGAGATGA GTCCAGTATGCCAGGCCCCTCACGGAAGGCTGCATGCTGGGCTGGGGAGGGGCCACCATCCTGCCTCTCC TTCCTCCACAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGA GGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTCTTCTGTCCA GACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGGTCAGTGCCC TCGGTCACACTGTGTGGCTGTCTGCTTACCTCCCCCAACCCCGGTGGACTAGGGTCCCTTTCTCTGATGT TCCCTCAACTGTCACCTCTCAAGGAAACCCCATTATCCCTACAAAAAATTCTTACTGCCTTCCAACCCCT GTGACCCCATTCTCTCCACGGTGACTGTGTCATACCCCAAAGGTGACCTCTGTTTTTCTCCTGTGACCCT GTCACCTTCCATGGAGTCCCCATCCCAGATCCGTGAGTGACCCCCATCATGACTTTCTTTCTTGTCCCCA GAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCA CCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAA GCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTGCCCTCTGA GACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGGTATGGAGTCCAGTCTAAGCAGAGAG ACTGATGGGCAGGGGAGGTGGGACCTTCAGCCCAGGGTCCACTGTGGGGGCAGAGGGAGTGGCAGAGACA CCGGGGTTCCTTCCCCTAATGGGTCACCTTCTCTTGACCTTTCAGAATATGTGAACCAGCCAGATGTTCG GCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGG CCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGA ACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGC CTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG ACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGC AGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCC CTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGT TCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTTGTGGATTCTG AGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATC CTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAA AAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGT CAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGTTTTTTTAAAGA TGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTCTCCACACC CACTTTGTCCATTTGCAAATATATTTTGGAAAACA
Protein Name	ERBB2_HUMAN
Length	1255
Moltype	AA
Topology	linear
Division	PRI
Update Date	12-OCT-2022
Create Date	13-AUG-1987
Definition	RecName: Full=Receptor tyrosine-protein kinase erbB-2; AltName: Full=Metastatic lymph node gene 19 protein; Short=MLN 19; AltName: Full=Proto-oncogene Neu; AltName: Full=Proto-oncogene c-ErbB-2; AltName: Full=Tyrosine kinase-type cell surface receptor HER2; AltName: Full=p185erbB2; AltName: CD_antigen=CD340; Flags: Precursor
Primary Accession	P04626
Accession Version	P04626.1
Other SeqIDs	sp\|P04626.1\|ERBB2_HUMAN,gi\|119533
Organism	Homo sapiens
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Comment	On Mar 15, 2005 this sequence version replaced gi:86984.; [FUNCTION] Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; [FUNCTION] In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.; [CATALYTIC ACTIVITY] Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255\|PROSITE-ProRule:PRU10028, ECO:0000269\|PubMed:21454582}.; ACTIVITY REGULATION: Activated by dimerization. Not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity. {ECO:0000269\|PubMed:18719096, ECO:0000269\|PubMed:21454582}.; [SUBUNIT] Homodimer (PubMed:21454582). Heterodimer with EGFR, ERBB3 and ERBB4 (PubMed:10358079, PubMed:15093539, PubMed:21190959, PubMed:16978839). Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196 (PubMed:10805725). Interacts with PLXNB1 (PubMed:15210733). Interacts (when phosphorylated on Tyr-1248) with MEMO1 (PubMed:15156151). Interacts with MUC1; the interaction is enhanced by heregulin (HRG) (PubMed:12939402). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain) (PubMed:12975581). Interacts (when phosphorylated on Tyr-1248) with ERBIN (PubMed:12444095). Interacts with KPNB1, RANBP2, EEA1, CRM1 and CLTC (PubMed:16314522). Interacts with PTK6 (PubMed:18719096). Interacts with RPA194 and ACTB (PubMed:21555369). Interacts with PRKCABP, SRC and MYOC (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (PubMed:20010870). Interacts with HSP90AA1 and HSP90AB1 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (PubMed:26517842). Interacts with SORL1; this interaction regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulates ERBB2-mediated signaling (PubMed:31138794). Interacts with SH3BGRL (PubMed:32381043). {ECO:0000250\|UniProtKB:P70424, ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:10805725, ECO:0000269\|PubMed:12939402, ECO:0000269\|PubMed:12975581, ECO:0000269\|PubMed:15093539, ECO:0000269\|PubMed:15156151, ECO:0000269\|PubMed:15210733, ECO:0000269\|PubMed:16314522, ECO:0000269\|PubMed:16978839, ECO:0000269\|PubMed:18719096, ECO:0000269\|PubMed:20010870, ECO:0000269\|PubMed:21190959, ECO:0000269\|PubMed:21454582, ECO:0000269\|PubMed:21555369, ECO:0000269\|PubMed:26517842, ECO:0000269\|PubMed:31138794, ECO:0000269\|PubMed:32381043}.; [INTERACTION] P04626; P00519: ABL1; NbExp=2; IntAct=EBI-641062, EBI-375543; P04626; P42684: ABL2; NbExp=6; IntAct=EBI-641062, EBI-1102694; P04626; P15309: ACP3; NbExp=2; IntAct=EBI-641062, EBI-1222012; P04626; P60709: ACTB; NbExp=10; IntAct=EBI-641062, EBI-353944; P04626; Q92625: ANKS1A; NbExp=2; IntAct=EBI-641062, EBI-1048612; P04626; O00213: APBB1; NbExp=2; IntAct=EBI-641062, EBI-81694; P04626; O75815: BCAR3; NbExp=2; IntAct=EBI-641062, EBI-702336; P04626; Q9HB71: CACYBP; NbExp=2; IntAct=EBI-641062, EBI-1047302; P04626; Q16543: CDC37; NbExp=5; IntAct=EBI-641062, EBI-295634; P04626; Q9NSE2: CISH; NbExp=4; IntAct=EBI-641062, EBI-617866; P04626; Q7Z7G1: CLNK; NbExp=2; IntAct=EBI-641062, EBI-7878194; P04626; P46109: CRKL; NbExp=2; IntAct=EBI-641062, EBI-910; P04626; Q93034: CUL5; NbExp=2; IntAct=EBI-641062, EBI-1057139; P04626; Q99704: DOK1; NbExp=2; IntAct=EBI-641062, EBI-1384360; P04626; Q8TEW6: DOK4; NbExp=2; IntAct=EBI-641062, EBI-6918542; P04626; Q15075: EEA1; NbExp=5; IntAct=EBI-641062, EBI-298113; P04626; P98172: EFNB1; NbExp=11; IntAct=EBI-641062, EBI-538287; P04626; P00533: EGFR; NbExp=25; IntAct=EBI-641062, EBI-297353; P04626; P04626: ERBB2; NbExp=12; IntAct=EBI-641062, EBI-641062; P04626; P21860: ERBB3; NbExp=29; IntAct=EBI-641062, EBI-720706; P04626; Q15303: ERBB4; NbExp=5; IntAct=EBI-641062, EBI-80371; P04626; Q9UJM3: ERRFI1; NbExp=4; IntAct=EBI-641062, EBI-2941912; P04626; P09769: FGR; NbExp=3; IntAct=EBI-641062, EBI-1383732; P04626; P06241: FYN; NbExp=2; IntAct=EBI-641062, EBI-515315; P04626; O75791: GRAP2; NbExp=2; IntAct=EBI-641062, EBI-740418; P04626; P62993: GRB2; NbExp=7; IntAct=EBI-641062, EBI-401755; P04626; Q14451: GRB7; NbExp=5; IntAct=EBI-641062, EBI-970191; P04626; P07900: HSP90AA1; NbExp=6; IntAct=EBI-641062, EBI-296047; P04626; P08238: HSP90AB1; NbExp=5; IntAct=EBI-641062, EBI-352572; P04626; P14625: HSP90B1; NbExp=2; IntAct=EBI-641062, EBI-359129; P04626; P11021: HSPA5; NbExp=3; IntAct=EBI-641062, EBI-354921; P04626; P46940: IQGAP1; NbExp=5; IntAct=EBI-641062, EBI-297509; P04626; P35568: IRS1; NbExp=2; IntAct=EBI-641062, EBI-517592; P04626; Q08881: ITK; NbExp=2; IntAct=EBI-641062, EBI-968552; P04626; P23458: JAK1; NbExp=2; IntAct=EBI-641062, EBI-1383438; P04626; Q14974: KPNB1; NbExp=14; IntAct=EBI-641062, EBI-286758; P04626; Q96JA1: LRIG1; NbExp=7; IntAct=EBI-641062, EBI-2865191; P04626; O75367: MACROH2A1; NbExp=6; IntAct=EBI-641062, EBI-2868511; P04626; O75367-3: MACROH2A1; NbExp=3; IntAct=EBI-641062, EBI-6250866; P04626; Q9UQF2: MAPK8IP1; NbExp=4; IntAct=EBI-641062, EBI-78404; P04626; Q13387: MAPK8IP2; NbExp=3; IntAct=EBI-641062, EBI-722813; P04626; P42679: MATK; NbExp=2; IntAct=EBI-641062, EBI-751664; P04626; Q9Y316: MEMO1; NbExp=6; IntAct=EBI-641062, EBI-1104564; P04626; O43639: NCK2; NbExp=2; IntAct=EBI-641062, EBI-713635; P04626; Q02297-7: NRG1; NbExp=2; IntAct=EBI-641062, EBI-2460927; P04626; O00750: PIK3C2B; NbExp=2; IntAct=EBI-641062, EBI-641107; P04626; P27986: PIK3R1; NbExp=12; IntAct=EBI-641062, EBI-79464; P04626; O00459: PIK3R2; NbExp=7; IntAct=EBI-641062, EBI-346930; P04626; Q92569: PIK3R3; NbExp=10; IntAct=EBI-641062, EBI-79893; P04626; P19174: PLCG1; NbExp=5; IntAct=EBI-641062, EBI-79387; P04626; P16885: PLCG2; NbExp=3; IntAct=EBI-641062, EBI-617403; P04626; O95602: POLR1A; NbExp=16; IntAct=EBI-641062, EBI-359472; P04626; Q13882: PTK6; NbExp=4; IntAct=EBI-641062, EBI-1383632; P04626; Q06124: PTPN11; NbExp=3; IntAct=EBI-641062, EBI-297779; P04626; Q05209: PTPN12; NbExp=4; IntAct=EBI-641062, EBI-2266035; P04626; Q99952: PTPN18; NbExp=6; IntAct=EBI-641062, EBI-1384210; P04626; Q99952-1: PTPN18; NbExp=5; IntAct=EBI-641062, EBI-12739708; P04626; P23467: PTPRB; NbExp=2; IntAct=EBI-641062, EBI-1265766; P04626; P08575: PTPRC; NbExp=2; IntAct=EBI-641062, EBI-1341; P04626; Q12913: PTPRJ; NbExp=2; IntAct=EBI-641062, EBI-2264500; P04626; Q15262: PTPRK; NbExp=2; IntAct=EBI-641062, EBI-474052; P04626; Q16827: PTPRO; NbExp=2; IntAct=EBI-641062, EBI-723739; P04626; Q15256: PTPRR; NbExp=2; IntAct=EBI-641062, EBI-2265659; P04626; P49792: RANBP2; NbExp=3; IntAct=EBI-641062, EBI-973138; P04626; P20936: RASA1; NbExp=8; IntAct=EBI-641062, EBI-1026476; P04626; O95980: RECK; NbExp=4; IntAct=EBI-641062, EBI-2823742; P04626; Q9NP31: SH2D2A; NbExp=2; IntAct=EBI-641062, EBI-490630; P04626; P29353: SHC1; NbExp=11; IntAct=EBI-641062, EBI-78835; P04626; P98077: SHC2; NbExp=3; IntAct=EBI-641062, EBI-7256023; P04626; Q92529: SHC3; NbExp=2; IntAct=EBI-641062, EBI-79084; P04626; Q9H6Q3: SLA2; NbExp=2; IntAct=EBI-641062, EBI-1222854; P04626; O15524: SOCS1; NbExp=2; IntAct=EBI-641062, EBI-968198; P04626; P12931: SRC; NbExp=11; IntAct=EBI-641062, EBI-621482; P04626; P42224: STAT1; NbExp=3; IntAct=EBI-641062, EBI-1057697; P04626; P40763: STAT3; NbExp=9; IntAct=EBI-641062, EBI-518675; P04626; P31948: STIP1; NbExp=2; IntAct=EBI-641062, EBI-1054052; P04626; Q7KZ85: SUPT6H; NbExp=2; IntAct=EBI-641062, EBI-2515547; P04626; P43405: SYK; NbExp=7; IntAct=EBI-641062, EBI-78302; P04626; Q9Y490: TLN1; NbExp=3; IntAct=EBI-641062, EBI-2462036; P04626; Q63HR2: TNS2; NbExp=4; IntAct=EBI-641062, EBI-949753; P04626; Q68CZ2: TNS3; NbExp=2; IntAct=EBI-641062, EBI-1220488; P04626; Q96D37: VAV1; NbExp=2; IntAct=EBI-641062, EBI-7875353; P04626; P52735: VAV2; NbExp=3; IntAct=EBI-641062, EBI-297549; P04626; O14980: XPO1; NbExp=3; IntAct=EBI-641062, EBI-355867.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269\|PubMed:32381043}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269\|PubMed:34380438}; Single-pass type I membrane protein {ECO:0000255}. Note=Internalized from the cell membrane in response to EGF stimulation. {ECO:0000269\|PubMed:32381043}.; [SUBCELLULAR LOCATION] [Isoform 1]: Cell membrane {ECO:0000269\|PubMed:31138794, ECO:0000269\|PubMed:33497358}; Single-pass type I membrane protein {ECO:0000255}. Early endosome {ECO:0000269\|PubMed:31138794}. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). {ECO:0000269\|PubMed:31138794}.; [SUBCELLULAR LOCATION] [Isoform 2]: Cytoplasm. Nucleus.; [SUBCELLULAR LOCATION] [Isoform 3]: Cytoplasm. Nucleus.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing, Alternative initiation; Named isoforms=6; Name=1; Synonyms=ERBB2, HER2; IsoId=P04626-1; Sequence=Displayed; Name=2; Synonyms=CTF-611; IsoId=P04626-2; Sequence=VSP_039249; Name=3; Synonyms=CTF-687; IsoId=P04626-3; Sequence=VSP_039250; Name=4; IsoId=P04626-4; Sequence=VSP_039248; Name=5; IsoId=P04626-5; Sequence=VSP_054787; Name=6; Synonyms=B; IsoId=P04626-6; Sequence=VSP_055902, VSP_055903, VSP_055904.; [TISSUE SPECIFICITY] Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO:0000269\|PubMed:15380516}.; [PTM] Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172, PubMed:33497358). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172). {ECO:0000269\|PubMed:17554007, ECO:0000269\|PubMed:27134172, ECO:0000269\|PubMed:33497358, ECO:0000305}.; [POLYMORPHISM] There are four alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012.; [DISEASE] Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {ECO:0000269\|PubMed:15457249}. Note=The gene represented in this entry is involved in disease pathogenesis.; [DISEASE] Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269\|PubMed:15457249, ECO:0000269\|PubMed:17344846}. Note=The gene represented in this entry is involved in disease pathogenesis.; [DISEASE] Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269\|PubMed:15457249}. Note=The gene represented in this entry is involved in disease pathogenesis.; [DISEASE] Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269\|PubMed:15457249, ECO:0000269\|PubMed:17344846}. Note=The protein represented in this entry is involved in disease pathogenesis.; [DISEASE] Note=Chromosomal aberrations involving ERBB2 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with CDK12, leading to CDK12-ERBB2 fusion leading to truncated CDK12 protein not in-frame with ERBB2. {ECO:0000269\|PubMed:21097718}.; [DISEASE] Visceral neuropathy, familial, 2, autosomal recessive (VSCN2) [MIM:619465]: An autosomal recessive disorder characterized by intestinal dysmotility due to aganglionosis (Hirschsprung disease), hypoganglionosis, and/or chronic intestinal pseudoobstruction. Patients also show peripheral axonal neuropathy, hypotonia, mild developmental delay, unilateral ptosis, and sensorineural hearing loss. {ECO:0000269\|PubMed:33497358}. Note=The disease is caused by variants affecting the gene represented in this entry.; [MISCELLANEOUS] [Isoform 2]: Produced by alternative initiation at Met-611 of isoform 1. {ECO:0000305}.; [MISCELLANEOUS] [Isoform 3]: Produced by alternative initiation at Met-687 of isoform 1. {ECO:0000305}.; [MISCELLANEOUS] [Isoform 4]: Produced by alternative splicing of isoform 1. {ECO:0000305}.; [SIMILARITY] Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00159}.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/ERBB2ID162ch17q11.html'.; [WEB RESOURCE] Name=NIEHS-SNPs; URL='http://egp.gs.washington.edu/data/erbb2/'.; [WEB RESOURCE] Name=Wikipedia; Note=ERBB2 entry; URL='https://en.wikipedia.org/wiki/ERBB2'.
Source Db	UniProtKB: locus ERBB2_HUMAN, accession P04626;; class: standard.; extra accessions:B2RZG3,B4DHN3,Q14256,Q6LDV1,Q9UMK4,X5D2V5; created: Aug 13, 1987.; sequence updated: Aug 13, 1987.; annotation updated: Oct 12, 2022.; xrefs: AH001455.2, AAA35808.1, X03363.1, CAA27060.1, M11730.1, AAA75493.1, M12036.1, AAA35978.1, AY208911.1, AAO18082.1, AK295195.1, BAG58195.1, CH471152.1, EAW60597.1, BC167147.1, AAI67147.1, M16792.1, AAA58637.1, M16789.1, M16790.1, M16791.1, KJ534964.1, AHW56604.1, L29395.1, AAA35809.1, M95667.1, AAC37531.1, A24571, NP_001005862.1, NP_001276865.1, NP_001276867.1, NP_004439.2, 1MFG_B, 1MFL_B, 1MW4_B, 1N8Z_C, 1QR1_C, 1QR1_F, 1S78_A, 1S78_B, 2A91_A, 2JWA_A, 2JWA_B, 2KS1_A, 2L4K_B, 2N2A_A, 2N2A_B, 3BE1_A, 3H3B_A, 3H3B_B, 3MZW_A, 3N85_A, 3PP0_A, 3PP0_B, 3RCD_A, 3RCD_B, 3RCD_C, 3RCD_D, 3WLW_A, 3WLW_B, 3WSQ_A, 4GFU_F, 4HRL_C, 4HRM_A, 4HRM_C, 4HRN_C, 4HRN_D, 4NND_C, 4NND_E, 4NND_F, 4NND_H, 5K33_C, 5KWG_C, 5MY6_A, 5O4G_C, 5OB4_A, 5OB4_B, 5TQS_E, 5TQS_F, 5TQS_G, 5TQS_H, 6ATT_A, 6BGT_C, 6J71_A, 6LBX_B, 6OGE_A, 7JXH_A, 7JXH_B, 7JXH_C, 7JXH_D, 7JXH_E, 7JXH_F, 7JXH_G, 7JXH_H, 7MN5_B, 7MN6_B, 7MN8_B; xrefs (non-sequence databases): CCDS:CCDS32642.1, CCDS:CCDS45667.1, CCDS:CCDS74052.1, PDBsum:1MFG, PDBsum:1MFL, PDBsum:1MW4, PDBsum:1N8Z, PDBsum:1QR1, PDBsum:1S78, PDBsum:2A91, PDBsum:2JWA, PDBsum:2KS1, PDBsum:2L4K, PDBsum:2N2A, PDBsum:3BE1, PDBsum:3H3B, PDBsum:3MZW, PDBsum:3N85, PDBsum:3PP0, PDBsum:3RCD, PDBsum:3WLW, PDBsum:3WSQ, PDBsum:4GFU, PDBsum:4HRL, PDBsum:4HRM, PDBsum:4HRN, PDBsum:4NND, PDBsum:5K33, PDBsum:5KWG, PDBsum:5MY6, PDBsum:5O4G, PDBsum:5OB4, PDBsum:5TQS, PDBsum:6ATT, PDBsum:6BGT, PDBsum:6J71, PDBsum:6LBX, PDBsum:6OGE, PDBsum:7JXH, PDBsum:7MN5, PDBsum:7MN6, PDBsum:7MN8, AlphaFoldDB:P04626, BMRB:P04626, SMR:P04626, BioGRID:108376, CORUM:P04626, DIP:DIP-8N, ELM:P04626, IntAct:P04626, MINT:P04626, STRING:9606.ENSP00000269571, BindingDB:P04626, ChEMBL:CHEMBL1824, DrugBank:DB08916, DrugBank:DB06021, DrugBank:DB12267, DrugBank:DB12010, DrugBank:DB04988, DrugBank:DB01259, DrugBank:DB14967, DrugBank:DB06366, DrugBank:DB11973, DrugBank:DB00072, DrugBank:DB05773, DrugBank:DB11652, DrugBank:DB05944, DrugBank:DB15035, DrugCentral:P04626, GuidetoPHARMACOLOGY:2019, MoonDB:P04626, TCDB:8.A.23.1.39, CarbonylDB:P04626, GlyConnect:1710, GlyGen:P04626, iPTMnet:P04626, PhosphoSitePlus:P04626, SwissPalm:P04626, BioMuta:ERBB2, DMDM:119533, CPTAC:CPTAC-192, CPTAC:CPTAC-193, CPTAC:CPTAC-194, CPTAC:CPTAC-195, CPTAC:CPTAC-693, EPD:P04626, jPOST:P04626, MassIVE:P04626, MaxQB:P04626, PaxDb:P04626, PeptideAtlas:P04626, PRIDE:P04626, ProteomicsDB:51718, ProteomicsDB:51719, ProteomicsDB:51720, ProteomicsDB:51721, ABCD:P04626, Antibodypedia:740, CPTC:P04626, DNASU:2064, Ensembl:ENST00000269571.10, Ensembl:ENSP00000269571.4, Ensembl:ENSG00000141736.14, Ensembl:ENST00000406381.6, Ensembl:ENSP00000385185.2, Ensembl:ENST00000541774.5, Ensembl:ENSP00000446466.1, Ensembl:ENST00000584601.5, Ensembl:ENSP00000462438.1, GeneID:2064, KEGG:hsa:2064, MANE-Select:ENST00000269571.10, UCSC:uc060esv.1, CTD:2064, DisGeNET:2064, GeneCards:ERBB2, HGNC:3430, HPA:ENSG00000141736, MalaCards:ERBB2, MIM:137800, MIM:164870, MIM:167000, MIM:211980, MIM:613659, MIM:619465, neXtProt:NX_P04626, OpenTargets:ENSG00000141736, Orphanet:388, PharmGKB:PA27844, VEuPathDB:HostDB:ENSG00000141736, eggNOG:KOG1025, GeneTree:ENSGT00940000158232, InParanoid:P04626, OMA:YVSDRHC, OrthoDB:81952at2759, PhylomeDB:P04626, TreeFam:TF106002, BRENDA:2.7.10.1, PathwayCommons:P04626, Reactome:R-HSA-1227986, Reactome:R-HSA-1250196, Reactome:R-HSA-1251932, Reactome:R-HSA-1257604, Reactome:R-HSA-1306955, Reactome:R-HSA-1358803, Reactome:R-HSA-1963640, Reactome:R-HSA-1963642, Reactome:R-HSA-2219530, Reactome:R-HSA-416572, Reactome:R-HSA-5673001, Reactome:R-HSA-6785631, Reactome:R-HSA-6811558, Reactome:R-HSA-8847993, Reactome:R-HSA-8863795, Reactome:R-HSA-8866910, Reactome:R-HSA-9634285, Reactome:R-HSA-9652282, Reactome:R-HSA-9664565, Reactome:R-HSA-9665233, Reactome:R-HSA-9665244, Reactome:R-HSA-9665245, Reactome:R-HSA-9665246, Reactome:R-HSA-9665247, Reactome:R-HSA-9665249, Reactome:R-HSA-9665250, Reactome:R-HSA-9665251, Reactome:R-HSA-9665348, Reactome:R-HSA-9665686, Reactome:R-HSA-9665737, SignaLink:P04626, SIGNOR:P04626, BioGRID-ORCS:2064, ChiTaRS:ERBB2, EvolutionaryTrace:P04626, GeneWiki:HER2/neu, GenomeRNAi:2064, Pharos:P04626, PRO:PR:P04626, Proteomes:UP000005640, RNAct:P04626, Bgee:ENSG00000141736, ExpressionAtlas:P04626, Genevisible:P04626, GO:0016324, GO:0009925, GO:0016323, GO:0005829, GO:0005769, GO:0010008, GO:0038143, GO:0016021, GO:0005887, GO:0043209, GO:0005634, GO:0048471, GO:0005886, GO:0043235, GO:0044214, GO:0005524, GO:0043125, GO:0042802, GO:0008022, GO:0046982, GO:0019903, GO:0004713, GO:0001042, GO:0004714, GO:0004888, GO:0007166, GO:0071364, GO:0071363, GO:0007167, GO:0038134, GO:0038133, GO:0038135, GO:0007507, GO:0033080, GO:0035556, GO:0008045, GO:0042552, GO:0033088, GO:0007528, GO:0030182, GO:0048709, GO:0018108, GO:0007422, GO:0014065, GO:0045785, GO:0030307, GO:0008284, GO:0050679, GO:0043547, GO:0033674, GO:0043406, GO:0043410, GO:0001934, GO:0090314, GO:0045943, GO:0045727, GO:0046777, GO:0006468, GO:0045765, GO:0070372, GO:0032886, GO:0007165, GO:0007169, GO:0042060, CDD:cd00064, DisProt:DP01484, Gene3D:3.80.20.20, IDEAL:IID00293, InterPro:IPR006211, InterPro:IPR006212, InterPro:IPR032778, InterPro:IPR009030, InterPro:IPR011009, InterPro:IPR000719, InterPro:IPR017441, InterPro:IPR000494, InterPro:IPR036941, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR020635, InterPro:IPR016245, Pfam:PF00757, Pfam:PF14843, Pfam:PF07714, Pfam:PF01030, PIRSF:PIRSF000619, PRINTS:PR00109, SMART:SM00261, SMART:SM00219, SUPFAM:SSF56112, SUPFAM:SSF57184, PROSITE:PS00107, PROSITE:PS50011, PROSITE:PS00109
Sequence	melaalcrwglllallppgaastqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqgyvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelqlrslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeegacqpcpincthscvdlddkgcpaeqraspltsiisavvgillvvvlgvvfgilikrrqqkirkytmrrllqetelvepltpsgampnqaqmrilketelrkvkvlgsgafgtvykgiwipdgenvkipvaikvlrentspkankeildeayvmagvgspyvsrllgicltstvqlvtqlmpygclldhvrenrgrlgsqdllnwcmqiakgmsyledvrlvhrdlaarnvlvkspnhvkitdfglarlldideteyhadggkvpikwmalesilrrrfthqsdvwsygvtvwelmtfgakpydgipareipdllekgerlpqppictidvymimvkcwmidsecrprfrelvsefsrmardpqrfvviqnedlgpaspldstfyrslledddmgdlvdaeeylvpqqgffcpdpapgaggmvhhrhrssstrsgggdltlglepseeeaprsplapsegagsdvfdgdlgmgaakglqslpthdpsplqrysedptvplpsetdgyvapltcspqpeyvnqpdvrpqppspregplpaarpagatlerpktlspgkngvvkdvfafggavenpeyltpqggaapqphpppafspafdnlyywdqdppergappstfkgtptaenpeylgldvpv