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|
| Record Information |
| Record ID |
45 |
| Pubmed ID |
31876334 |
| SNP |
|
| Gene ID |
4582 |
| Protein ID |
P15941 |
| Vaccine Adverse Events |
depressed level of consciousness associated with fever, fatigue, chills |
| Vaccine |
BN-Brachyury vaccine |
| Gene Name |
MUC1 |
| Official Symbol |
mucin 1, cell surface associated [Homo sapiens (human)] |
| Aliases |
ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X/ZD, PEM, PEMT, PUM, MUC1 |
| Other Designations |
mucin-1; H23 antigen; breast carcinoma-associated antigen DF3; cancer antigen 15-3; carcinoma-associated mucin; episialin; krebs von den Lungen-6; mucin 1, transmembrane; peanut-reactive urinary mucin; polymorphic epithelial mucin; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen |
| Chromosome |
1 |
| Location |
1q22 |
| Annotation |
Chromosome 1 NC_000001.11 (155185824..155192915, complement) |
| MIM |
158340 |
| DNA Sequence |
>NC_000001.11:155185824-155192915 Homo sapiens chromosome 1, GRCh38.p14 Primary Assembly
TTGGCGCAGTGGGAGACCACGTTTTATTCAGTCCAGTTCAGGATCCCCGCTATCTCAGGGCTCTCTGGGC
CAGTCCTCCTGGGAGCCCCCACCACAACACTTCCCAGGCATGAGCCCTCAGGGGCCCACATGAGCTTCCA
CACACTGAGAAGTGTCCGAGAAATTGGTGGGGCCTCTGAAGGAGGCTGTGAGCAGCCCACCTGAACTCCC
AGCTCACCAGCCCAAACAGGGTGCAGGGGCTCTGGCCCTGAAGAACCTGAGTGGAGTGGAATGGCACTGG
CTGGCCACTCAGCTCAGCGGGCGACGTGCCCCTACAAGTTGGCAGAAGTGGCTGCCACTGCTGGGTTTGT
GTAAGAGAGGCTGCTGCCACCATTACCTGCAGAAACCTGGGTGGAAGGAAAAGAGATCCAGGGTGAGGAG
CAAAAGGTACCTCCTAGAGCCCCTGGATGCCACCCCAGGCTGGGGTAATCAGTCCAGAGTCCTGGCCAGC
TCTCAAAGGGTTAATTCAGAGAGAGCACCTGCCACCCCACCAGCCAGGTGACTGTAAACAGGGCTGCCCT
CCTCCCTCTGCTCTCCTTCACTCCCTCTTCTTGGCTCTAATCAGCCCCCTTGTCCCTCCATTCTCTGCTG
TTCCAGCCTAAGGAGGTGTGTGTGTGTGTGTGTGTGTGTTTTGGGGGGCGGGGTGTATCTGTGTCTTTGT
AAAGCCGAGAGAGGGAGGTCTCCAGGAGGAGGAAAATAGGAGCAAGAAAACTAAACTCTCTCCTCCCCCA
CCTGGAGTGGTTTTCCAGCCTCAGGTGGCTGCAGTAATTATTTACTAGGTCCCATAGAGAAAGACCAGGA
GAGGAAGGAGGGAGCGTTCCTTGCTTCCTTGAAGCTCCCAAGAACCCCACTGGCACCCACGCTCACCTGG
TCTGCTGACACTTCTTCTTCTACCTGGGAAACCTCCCCCTATGCCAGCCTTTCTCGGTCTACCCTCCATT
CCTAGGAGATGATTAGGGGCACAGAGGCTCACCCCTGGGACTCCTCGGGAAGGGCTCCCCTGGGCATAGT
GCTCCACCCATTTTGCCTCTGGGTGCAAAAAAGCAAAACAAAACAAAACTGCCACGGTGGCACCAGTTCA
GCCAGCGCCAGCCAGCATGAATGTGGACGGCCAATGATCTTTTAGGAATTCTGGCAGTGGGGCCACTCCC
TCTTGAGGGCCCCTTTCTTCCATAGTCTCCTCCCAGGCCTGTCCCCCAAAACTCCTCTGACCTCTGCCCC
TCATCCTTGCCAGGCCCTCCCCTGCTCACTTCACGCCACTTCTCACCTCTTCCAAGCTCTTTGGGTTTTC
CAAGTACCCCCTTCAGAATCCTTGCCCAGCCAAACCCTCTGCTTCCCCTGGCCTGTGGGGCCCAATCTCA
CCTTCTCATAGGGGCTACGATCGGTACTGCTAGGGGGCACATAGCGCCCATGGGTGTGGTAGGTGGGGTA
CTCGCTCATAGGATGGTAGGTATCCCGGGCTGGAAAGATGTCCAGCTGCCCGTAGTTCTTTCGGCGGCAC
TGACAGACAGCCTGGGGAGATAGGAGGTTATGGCAGGCCATGGAGTGCCTTCTACCGGGGGGCTCTGATC
AGGGCCAGGGACTGCACTCACCAAGGCAATGAGATAGACAATGGCCAGCGCAACCAGAACACAGACCAGC
ACCAGCAGCGCGATGCCCCAGCCTGGCACCCCAGCCCCAGACTGGGCAGAGAAAGGAAATGGCACATCAC
TCACTAAAAGGAAAAGCAGTGGTCAGGGCAGTCTCCCAGAGGAGGCGCCCCTCCCGCTGCCAGCACTAAG
GAAAGAGCGGGGACCCAGACACTGGAAGGAGAGGGGCCCCGGCATGGTGCTGGGCTGCAGCCAGGGAAGT
AGCCTCACCGCTGACGTCTGAGATCGTCAGGTTATATCGAGAGGCTGCTTCCGTTTTATACTGATTGAAC
TGTGTCTCCACGTCGTGGACATTGATGGTACCTTCTCGGAAGGCCAGAGTCAATTGTACCACCACAGATC
CTGGCCTGGTCACAGGGAAATGGGCACTTCAGCCACGGGTCCCAGCTCTGGCTCAGCACTCTTCCCCCAA
CCTTAAGTGCACCAGTCCCTCCCTACGGTCATGACCACCACCCACCCTCCAACCACCACACTGGGTCCAC
ACCCAGAACTGTACCTGAACTTAATATTGGAGAGGCCCAGAAAACCCCCTTGTTTATAAATCTGCAAAAA
CTGGGGTGAGAGGGAAAGGACTCAGGCTTGATGCAAAGGGTGTGGACAGTTCTGATGGCTGCTTCAGGGG
AGCATGGGGAAGGAAAGGCCGATACTCACCATTTCAGAAATGTCTCTCTGCAGCTCTTGGTAGTAGTCGG
TGCTGGGATCTTCCAGAGAGGAATTAAACTGGAGGTTTGAAATGTGAAAAGACAGGAAAAAGAAAGAGAC
CCCAGTAGACAACTGGGGAGAAGTGCTGTGATTGGAGGAGGTGAGAGGAGGTACCGTGCTATGGTGAGTG
CTACTGGCATCAGTCTTGGTGCTATGGCTGGCAAGGGTGGTAGGAGTATCAGAGTGGTGGCTGGGAATTG
AGAATGGAGTGCTCTTGCTGGCTGGGGTTGTGGTAGCCCTGGCAGAGGTGCCGTTGTGCACCAGAGTAGA
AGCTGAGCCTGATGCAGAGCCTGAGGCCGAGGTGACATTGTGGACTGGAGGGGCGGTGGAGCCCAAGGCG
GGCCTGTTGTCCGGGGCCGAGGTGACACCATGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGT
CCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGGGTGGAGCCCGGGGCCCG
CCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGTGCGGTGGAGCCCGGGGCCGGCCTGGTGTCC
GGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGG
TGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGTGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTG
GACTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGG
GCGGTGGAGCCCGGGGGCCGGCCTGGTGTCCGGTGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAG
CCCGGAGCCGGTCTGTTGTCCGGGGCCGAGGTGACACCGTGTGCTGGAGTGTCGGTGGAGCCCGAGGCCG
GCCTGGTGTCCGGGGCCGAGGTGACACTGTGAGCTGGGCTGCGGGCGCGGTGGAGCCCGGGGCCGGCCTG
CTCTCTGTTTTAAATATACACCGTGGGCTGCGGGCGCGGTGGAGCCCGGGGACGGCCTGGTGTCCGGGGC
CGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACA
CCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTG
GGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGT
GGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGG
GCCGGCCTGCTCTCCGGGGCCGAGGTGACACCGTGGGCTGCTCTCGCGGTGGAGCCCGGGGCCGGCCTGC
TCTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGC
CGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACA
CCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTT
GGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGCGGGCGCGGT
GTAGCCCGGGGCGGGCCTTGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGG
GCGGGACTGGTGTCCGGGGCCGAGGTGACACCGTGGGTTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGG
TGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGCTCTCCGGGGC
CGAGGTGACACCGTGGGCTGCGGGCGCGGTGGAGCCCGGGGCCGGCCTGCTCTCCGGGGCCGAGGTGACA
CCGTGGGCTGCGGGCGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTG
GGGGCGCGGTGGAGCCCGGGCCAGAACTGCTTTCCGGGGCCGTGGTGACTCCGTGGGCTGCGGGCGCGGT
GGAGCCCGGGGCCGGCCTGCTCTCTGGGGCCGAGGTGACACCGTGGGCTGCGGGCGCGGTGGAGCCCGGG
GCGGAACTCTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGGGGGGGAGCCCGGGGCCGGCCTGGTGT
CCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCTGGGGCCGGCCTGGTGTCCGGGGCCG
AGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACC
GTGGGCTTGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGCG
GGCGCGGTGGAGCCCGGGGCGGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGG
AGCCCGGGGCGGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGC
CGGCCTGGTGTCCGGGGTCGAGGTGACACCGTGGGCTTGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTG
TCTGGGGGGGCGGTGGAGCCGGGGCCGGCCTGGTGTCCGGGGTTGGAAAACTGGGCTGGGGGGGCGGTGG
AGCCCGGGGCCGGCAGGGGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCC
GGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTTGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGT
CCGGGGCCGAGGTGACACCGTGGGCTGCGGGCGCGGTGGAGCCCGGGGCGGGCCTGGTGTCCGGGGCCGA
GGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCGGGCCTGGTGTCCGGGGCCGAGGTGACACCG
TGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTTGGG
GGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGCGGGCGCGGTGGA
GCCCGGGTCCGTCCTTCTCTCCGAGGGCCGAGGTGACATCGTAGACTGCGGGCGCGGTGGAGCCCGGGTC
CGGCCTGCTCTCCGAGGCCGAGGTGACACCGTAGACTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTG
TCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGAACCGGCCTGGTGTCCGGGGCCG
AGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTGTCCGGGGCCGAGGTGACACC
GTGGGCTTGGGGGGCGGTGGAGCCCGGGACCGACCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGCG
GGCGCGGTGGAGCCCGGGGCGGACCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGG
AGCCCGGGGCGGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGC
CGGCCTGGTGTCCGGGGCCGAGGTGACACCGTGGGCTTGGGGGGCGGTGGAGCCCGGGGCCGGCCTGGTG
TCCGGGGCCGAGGTGACACCGTGGGCTGGGGGGGCGGTGGAGCCCGGGGCTGGCTTGTTGTCCGGGGCTG
AGGTGACATCGTGGGCTGGCGGGGTGGTGGAGCCCAGGGCTGGCCTGGTGACTGGGACCGAGGTGACATC
CTGTCCCCAGGTGGCAGCTGAACCTGAAGCTGGTTCCGTGGCCGGGGCCAGAGTGACATCCTGTCCCTGA
GTGGTGGAGGAGCCTGAACCGGGGCTGTGGCTGGAGAGTACGCTGCTGGTCATACTCACAGCATTCTTCT
CAGTAGAGCTGGGCACTGAACTTCTCTGGGTAGCCGAAGTCTCCTTTTCTCCACCTGGGGTAGAGCTTGC
ATGACCAGAACCCGTAACAACTGTTGCGGGTTTAGGGGCTGTGGTAGCTGTAAGAAGTTAAAGTCATAGG
GTTGGGTCTTTATGAAGGAAAAATAAGAGCAAGAAGAAAATATAAGCTCTGGCCACCAGAGAAATAATAC
CAGGAGGACTGGGGAGTGGGCAGCCTCAGTAACCCCTGGGTTGGCCGCCTCCTTCCCTGCAGCAGCCTCC
TTCTCTCTGCCCATAGGCCTTGGCTCATGGCCCCTGCATTTCTTCCCCTCTTAAGCCTTCCCTCTCCCTA
CTCTCTTCCCCCTAGACTTCTCTACAGGACATTTGCTTGCCCCTGGTACCCACTCTCAGGGTTGGGGGCA
ACTCTTCTCAGCCTGTCCTTAGCCTCTCCCTCCTTCTGGCACAGACAGGGCAGCCTCTGTCTGCAATTCT
TACCTTAACTTCATGGTGCCATCTGCCAGGGAGCAAAACCCACAGAAAGACCACGAAGACCACCTAAGCA
GGGCAGCCCACTCCCCACCTCGTGCCCCTCACCTGTAAGCACTGTGAGGAGCAGCAGCAGGAAGAAAGGA
GACTGGGTGCCCGGTGTCATGGTGGTGGTGAAATGGGTGGGGAGGGGGCAGAACAGATTCAGGCAGGCGC
TGGCTGCTTGAGAGGTGGAGCG
|
| Protein Name |
MUC1_HUMAN |
| Length |
1255 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-APR-1990 |
| Definition |
RecName: Full=Mucin-1; Short=MUC-1; AltName: Full=Breast carcinoma-associated antigen DF3; AltName: Full=Cancer antigen 15-3; Short=CA 15-3; AltName: Full=Carcinoma-associated mucin; AltName: Full=Episialin; AltName: Full=H23AG; AltName: Full=Krebs von den Lungen-6; Short=KL-6; AltName: Full=PEMT; AltName: Full=Peanut-reactive urinary mucin; Short=PUM; AltName: Full=Polymorphic epithelial mucin; Short=PEM; AltName: Full=Tumor-associated epithelial membrane antigen; Short=EMA; AltName: Full=Tumor-associated mucin; AltName: CD_antigen=CD227; Contains: RecName: Full=Mucin-1 subunit alpha; Short=MUC1-NT; Short=MUC1-alpha; Contains: RecName: Full=Mucin-1 subunit beta; Short=MUC1-beta; AltName: Full=MUC1-CT; Flags: Precursor |
| Primary Accession |
P15941 |
| Accession Version |
P15941.3 |
| Other SeqIDs |
sp|P15941.3|MUC1_HUMAN,gi|296439295 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Sep 20, 2013 this sequence version replaced gi:74750114, gi:74722803, gi:74713603, gi:74750115, P15941.2.; [FUNCTION] The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; [FUNCTION] The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.; [SUBUNIT] The alpha subunit forms a tight, non-covalent heterodimeric complex with the proteolytically-released beta-subunit. Interaction, via the tandem repeat region, with domain 1 of ICAM1 is implicated in cell migration and metastases. Isoform 1 binds directly the SH2 domain of GRB2, and forms a MUC1/GRB2/SOS1 complex involved in RAS signaling. The cytoplasmic tail (MUC1CT) interacts with several proteins such as SRC, CTNNB1 and ERBs. Interaction with the SH2 domain of CSK decreases interaction with GSK3B. Interacts with CTNNB1/beta-catenin and JUP/gamma-catenin and promotes cell adhesion. Interaction with JUP/gamma-catenin is induced by heregulin. Binds PRKCD, ERBB2, ERBB3 and ERBB4. Heregulin (HRG) stimulates the interaction with ERBB2 and, to a much lesser extent, the interaction with ERBB3 and ERBB4. Interacts with P53 in response to DNA damage. Interacts with KLF4. Interacts with estrogen receptor alpha/ESR1, through its DNA-binding domain, and stimulates its transcription activity. Binds ADAM17. Isoform ZD forms disulfide-linked oligomers. {ECO:0000269|PubMed:11152665, ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:12750561, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:14688481, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15513966, ECO:0000269|PubMed:15710329, ECO:0000269|PubMed:16288032, ECO:0000269|PubMed:16427018, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:16983337, ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:7664271, ECO:0000269|PubMed:9139698, ECO:0000269|PubMed:9819408}.; [INTERACTION] P15941; P00519: ABL1; NbExp=8; IntAct=EBI-2804728, EBI-375543; P15941; P00533: EGFR; NbExp=4; IntAct=EBI-2804728, EBI-297353; P15941; P08581: MET; NbExp=2; IntAct=EBI-2804728, EBI-1039152; P15941; P15941-7: MUC1; NbExp=2; IntAct=EBI-2804728, EBI-4396776; P15941-11; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-17263240, EBI-10225815; P15941-11; O60242: ADGRB3; NbExp=3; IntAct=EBI-17263240, EBI-2682765; P15941-11; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-17263240, EBI-10827839; P15941-11; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-17263240, EBI-12109402; P15941-11; P02652: APOA2; NbExp=3; IntAct=EBI-17263240, EBI-1171525; P15941-11; P05067-2: APP; NbExp=3; IntAct=EBI-17263240, EBI-17264467; P15941-11; P29972: AQP1; NbExp=3; IntAct=EBI-17263240, EBI-745213; P15941-11; P41181: AQP2; NbExp=3; IntAct=EBI-17263240, EBI-12701138; P15941-11; Q92482: AQP3; NbExp=3; IntAct=EBI-17263240, EBI-2808854; P15941-11; Q9H2C2: ARV1; NbExp=3; IntAct=EBI-17263240, EBI-11724186; P15941-11; Q92843: BCL2L2; NbExp=3; IntAct=EBI-17263240, EBI-707714; P15941-11; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-17263240, EBI-12244618; P15941-11; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-17263240, EBI-8648738; P15941-11; P06681: C2; NbExp=3; IntAct=EBI-17263240, EBI-2835920; P15941-11; O14523: C2CD2L; NbExp=3; IntAct=EBI-17263240, EBI-12822627; P15941-11; Q06432: CACNG1; NbExp=3; IntAct=EBI-17263240, EBI-9686780; P15941-11; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-17263240, EBI-9083477; P15941-11; Q08722-3: CD47; NbExp=3; IntAct=EBI-17263240, EBI-17263290; P15941-11; P19397: CD53; NbExp=3; IntAct=EBI-17263240, EBI-6657396; P15941-11; P34810: CD68; NbExp=3; IntAct=EBI-17263240, EBI-2826276; P15941-11; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-17263240, EBI-12256978; P15941-11; P56747: CLDN6; NbExp=3; IntAct=EBI-17263240, EBI-12955011; P15941-11; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-17263240, EBI-11959453; P15941-11; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-17263240, EBI-2807956; P15941-11; Q4VAQ0: COL8A2; NbExp=3; IntAct=EBI-17263240, EBI-10241815; P15941-11; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-17263240, EBI-10267100; P15941-11; Q07325: CXCL9; NbExp=3; IntAct=EBI-17263240, EBI-3911467; P15941-11; O43169: CYB5B; NbExp=3; IntAct=EBI-17263240, EBI-1058710; P15941-11; P78329: CYP4F2; NbExp=3; IntAct=EBI-17263240, EBI-1752413; P15941-11; P56851: EDDM3B; NbExp=3; IntAct=EBI-17263240, EBI-10215665; P15941-11; Q9BV81: EMC6; NbExp=3; IntAct=EBI-17263240, EBI-2820492; P15941-11; P54852: EMP3; NbExp=3; IntAct=EBI-17263240, EBI-3907816; P15941-11; O75355-2: ENTPD3; NbExp=3; IntAct=EBI-17263240, EBI-12279764; P15941-11; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-17263240, EBI-711490; P15941-11; P01350: GAST; NbExp=3; IntAct=EBI-17263240, EBI-3436637; P15941-11; P39905-3: GDNF; NbExp=3; IntAct=EBI-17263240, EBI-12702062; P15941-11; Q9Y3E0: GOLT1B; NbExp=3; IntAct=EBI-17263240, EBI-4402607; P15941-11; Q9NPR9: GPR108; NbExp=3; IntAct=EBI-17263240, EBI-11343451; P15941-11; Q9HCP6: HHATL; NbExp=3; IntAct=EBI-17263240, EBI-5916693; P15941-11; O60725: ICMT; NbExp=3; IntAct=EBI-17263240, EBI-11721771; P15941-11; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-17263240, EBI-8503746; P15941-11; P11215: ITGAM; NbExp=3; IntAct=EBI-17263240, EBI-2568251; P15941-11; Q969L2: MAL2; NbExp=3; IntAct=EBI-17263240, EBI-944295; P15941-11; Q13021: MALL; NbExp=3; IntAct=EBI-17263240, EBI-750078; P15941-11; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-17263240, EBI-10317612; P15941-11; Q6N075: MFSD5; NbExp=3; IntAct=EBI-17263240, EBI-3920969; P15941-11; P30301: MIP; NbExp=3; IntAct=EBI-17263240, EBI-8449636; P15941-11; Q96S97: MYADM; NbExp=3; IntAct=EBI-17263240, EBI-13301517; P15941-11; O95167: NDUFA3; NbExp=3; IntAct=EBI-17263240, EBI-1246131; P15941-11; Q99519: NEU1; NbExp=3; IntAct=EBI-17263240, EBI-721517; P15941-11; Q92982: NINJ1; NbExp=3; IntAct=EBI-17263240, EBI-2802124; P15941-11; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-17263240, EBI-10317425; P15941-11; Q16617: NKG7; NbExp=3; IntAct=EBI-17263240, EBI-3919611; P15941-11; Q8N912: NRAC; NbExp=3; IntAct=EBI-17263240, EBI-12051377; P15941-11; Q8NH19: OR10AG1; NbExp=3; IntAct=EBI-17263240, EBI-13339917; P15941-11; Q6TCH4: PAQR6; NbExp=3; IntAct=EBI-17263240, EBI-17265310; P15941-11; P26678: PLN; NbExp=3; IntAct=EBI-17263240, EBI-692836; P15941-11; P60201-2: PLP1; NbExp=3; IntAct=EBI-17263240, EBI-12188331; P15941-11; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-17263240, EBI-11721828; P15941-11; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-17263240, EBI-8652812; P15941-11; Q59EV6: PPGB; NbExp=3; IntAct=EBI-17263240, EBI-14210385; P15941-11; P30405: PPIF; NbExp=3; IntAct=EBI-17263240, EBI-5544229; P15941-11; Q96AA3: RFT1; NbExp=3; IntAct=EBI-17263240, EBI-6269616; P15941-11; Q02161-2: RHD; NbExp=3; IntAct=EBI-17263240, EBI-17249212; P15941-11; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-17263240, EBI-2695784; P15941-11; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-17263240, EBI-9679163; P15941-11; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-17263240, EBI-749270; P15941-11; P11686: SFTPC; NbExp=3; IntAct=EBI-17263240, EBI-10197617; P15941-11; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-17263240, EBI-10262251; P15941-11; Q969S0: SLC35B4; NbExp=3; IntAct=EBI-17263240, EBI-10281213; P15941-11; Q6ICL7: SLC35E4; NbExp=3; IntAct=EBI-17263240, EBI-12867720; P15941-11; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-17263240, EBI-10314552; P15941-11; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-17263240, EBI-8640191; P15941-11; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-17263240, EBI-12188413; P15941-11; Q9NZ01: TECR; NbExp=3; IntAct=EBI-17263240, EBI-2877718; P15941-11; P07204: THBD; NbExp=3; IntAct=EBI-17263240, EBI-941422; P15941-11; Q9BZW4: TM6SF2; NbExp=3; IntAct=EBI-17263240, EBI-13082040; P15941-11; P17152: TMEM11; NbExp=3; IntAct=EBI-17263240, EBI-723946; P15941-11; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-17263240, EBI-10171534; P15941-11; Q9BTD3: TMEM121; NbExp=3; IntAct=EBI-17263240, EBI-12155101; P15941-11; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-17263240, EBI-10694905; P15941-11; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-17263240, EBI-348587; P15941-11; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-17263240, EBI-2800360; P15941-11; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-17263240, EBI-2339195; P15941-11; Q14656: TMEM187; NbExp=3; IntAct=EBI-17263240, EBI-13046724; P15941-11; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-17263240, EBI-12195227; P15941-11; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-17263240, EBI-12887458; P15941-11; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-17263240, EBI-12015604; P15941-11; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-17263240, EBI-2548832; P15941-11; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-17263240, EBI-12111910; P15941-11; Q9Y2Y6: TMEM98; NbExp=3; IntAct=EBI-17263240, EBI-7333781; P15941-11; O14763: TNFRSF10B; NbExp=3; IntAct=EBI-17263240, EBI-518882; P15941-11; Q8N609: TRAM1L1; NbExp=3; IntAct=EBI-17263240, EBI-11996766; P15941-11; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-17263240, EBI-10243654; P15941-11; Q53HI1: UNC50; NbExp=3; IntAct=EBI-17263240, EBI-7601760; P15941-11; O95183: VAMP5; NbExp=3; IntAct=EBI-17263240, EBI-10191195; P15941-11; Q9BQB6: VKORC1; NbExp=3; IntAct=EBI-17263240, EBI-6256462; P15941-11; Q8IVQ6: ZDHHC21; NbExp=3; IntAct=EBI-17263240, EBI-2849773; PRO_0000317447; P17676: CEBPB; NbExp=8; IntAct=EBI-10053698, EBI-969696.; [SUBCELLULAR LOCATION] Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}; Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.; [SUBCELLULAR LOCATION] [Isoform 5]: Secreted.; [SUBCELLULAR LOCATION] [Isoform Y]: Secreted.; [SUBCELLULAR LOCATION] [Isoform 9]: Secreted.; [SUBCELLULAR LOCATION] [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=17; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=A; IsoId=P15941-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P15941-2; Sequence=VSP_003280; Name=3; Synonyms=C; IsoId=P15941-3; Sequence=VSP_003281; Name=4; Synonyms=D; IsoId=P15941-4; Sequence=VSP_003282; Name=5; Synonyms=SEC; IsoId=P15941-5; Sequence=VSP_003288, VSP_003289; Name=6; Synonyms=X; IsoId=P15941-6; Sequence=VSP_003283, VSP_003284; Name=Y; Synonyms=MUC1/Y; IsoId=P15941-7; Sequence=VSP_003285; Name=8; Synonyms=Z; IsoId=P15941-8; Sequence=VSP_003286; Name=9; Synonyms=S; IsoId=P15941-9; Sequence=VSP_003286, VSP_003287; Name=F; IsoId=P15941-10; Sequence=VSP_035046, VSP_035047; Name=Y-LSP; IsoId=P15941-11; Sequence=VSP_003280, VSP_003285; Name=S2; IsoId=P15941-12; Sequence=VSP_003280, VSP_003285, VSP_003287; Name=M6; IsoId=P15941-13; Sequence=VSP_003286, VSP_046962, VSP_046963; Name=ZD; Synonyms=J19; IsoId=P15941-14; Sequence=VSP_047575, VSP_047576; Name=T10; IsoId=P15941-15; Sequence=VSP_003280, VSP_047873; Name=E2; IsoId=P15941-16; Sequence=VSP_003280, VSP_047872; Name=J13; IsoId=P15941-17; Sequence=VSP_003280, VSP_003285, VSP_047874.; [TISSUE SPECIFICITY] Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only. {ECO:0000269|PubMed:15513966, ECO:0000269|PubMed:9212228}.; [DEVELOPMENTAL STAGE] During fetal development, expressed at low levels in the colonic epithelium from 13 weeks of gestation. {ECO:0000269|PubMed:9536947}.; [PTM] Highly glycosylated (N- and O-linked carbohydrates and sialic acid). O-glycosylated to a varying degree on serine and threonine residues within each tandem repeat, ranging from mono- to penta-glycosylation. The average density ranges from about 50% in human milk to over 90% in T47D breast cancer cells. Further sialylation occurs during recycling. Membrane-shed glycoproteins from kidney and breast cancer cells have preferentially sialyated core 1 structures, while secreted forms from the same tissues display mainly core 2 structures. The O-glycosylated content is overlapping in both these tissues with terminal fucose and galactose, 2- and 3-linked galactose, 3- and 3,6-linked GalNAc-ol and 4-linked GlcNAc predominating. Differentially O-glycosylated in breast carcinomas with 3,4-linked GlcNAc. N-glycosylation consists of high-mannose, acidic complex-type and hybrid glycans in the secreted form MUC1/SEC, and neutral complex-type in the transmembrane form, MUC1/TM. {ECO:0000269|PubMed:10373415, ECO:0000269|PubMed:7744025, ECO:0000269|PubMed:9312074, ECO:0000269|PubMed:9597769}.; [PTM] Proteolytic cleavage in the SEA domain occurs in the endoplasmic reticulum by an autoproteolytic mechanism and requires the full-length SEA domain as well as requiring a Ser, Thr or Cys residue at the P + 1 site. Cleavage at this site also occurs on isoform MUC1/X but not on isoform MUC1/Y. Ectodomain shedding is mediated by ADAM17. {ECO:0000269|PubMed:11341784, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:15987679}.; [PTM] Dual palmitoylation on cysteine residues in the CQC motif is required for recycling from endosomes back to the plasma membrane. {ECO:0000269|PubMed:16507569}.; [PTM] Phosphorylated on tyrosines and serine residues in the C-terminal. Phosphorylation on tyrosines in the C-terminal increases the nuclear location of MUC1 and beta-catenin. Phosphorylation by PKC delta induces binding of MUC1 to beta-catenin/CTNNB1 and thus decreases the formation of the beta-catenin/E-cadherin complex. Src-mediated phosphorylation inhibits interaction with GSK3B. Src- and EGFR-mediated phosphorylation on Tyr-1229 increases binding to beta-catenin/CTNNB1. GSK3B-mediated phosphorylation on Ser-1227 decreases this interaction but restores the formation of the beta-cadherin/E-cadherin complex. On T-cell receptor activation, phosphorylated by LCK. PDGFR-mediated phosphorylation increases nuclear colocalization of MUC1CT and CTNNB1. {ECO:0000269|PubMed:11152665, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12750561, ECO:0000269|PubMed:14521915, ECO:0000269|PubMed:15513966, ECO:0000269|PubMed:16288032, ECO:0000269|PubMed:17545600, ECO:0000269|PubMed:7664271, ECO:0000269|PubMed:7988707, ECO:0000269|PubMed:9819408}.; [PTM] The N-terminal sequence has been shown to begin at position 24 or 28. {ECO:0000269|PubMed:11341784}.; [POLYMORPHISM] The number of repeats is highly polymorphic. It varies from 21 to 125 in the northern European population. The most frequent alleles contains 41 and 85 repeats. The tandemly repeated icosapeptide underlies polymorphism at three positions: PAPGSTAP[PAQT]AHGVTSAP[DT/ES]R, DT -> ES and the single replacements P -> A, P -> Q and P-> T. The most frequent replacement DT -> ES occurs in up to 50% of the repeats.; [DISEASE] Note=MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence (PubMed:20816948). Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes. {ECO:0000269|PubMed:20816948}.; [DISEASE] Tubulointerstitial kidney disease, autosomal dominant, 2 (ADTKD2) [MIM:174000]: A form of autosomal dominant tubulointerstitial kidney disease, a genetically heterogeneous disorder characterized by slowly progressive loss of kidney function, bland urinary sediment, hyperuricemia, absent or mildly increased albuminuria, lack of severe hypertension during the early stages, and normal or small kidneys on ultrasound. Renal histology shows variable abnormalities including interstitial fibrosis with tubular atrophy, microcystic dilatation of the tubules, thickening of tubular basement membranes, medullary cysts, and secondary glomerulosclerotic or glomerulocystic changes with abnormal glomerular tufting. There is significant variability, as well as incomplete penetrance. {ECO:0000269|PubMed:23396133}. Note=The disease is caused by variants affecting the gene represented in this entry.; [MISCELLANEOUS] The name KL-6 was originally that of a murine monoclonal antibody reacting with pulmonary adenocarcinoma cell lines and pulmonary epithelial cells. This antibody recognizes a sialylated carbohydrate chain on MUC1.; [MISCELLANEOUS] [Isoform Y-LSP]: Lacks the mucin repeats. {ECO:0000305}.; [MISCELLANEOUS] [Isoform ZD]: Lacks the mucin repeats. Exists as a disulfide-linked oligomer. {ECO:0000305}.; [CAUTION] O-glycosylation sites are annotated in first sequence repeat only. Residues at similar position are probably glycosylated in all repeats. Experimental sites were determined in a synthetic peptide glycosylated in vitro (PubMed:7744025, PubMed:9597769). {ECO:0000305|PubMed:7744025, ECO:0000305|PubMed:9597769}.; [SEQUENCE CAUTION] Sequence=AAD14369.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAD14376.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}.; [WEB RESOURCE] Name=Mucin database; URL='http://www.medkem.gu.se/mucinbiology/databases/'.; [WEB RESOURCE] Name=NIEHS-SNPs; URL='http://egp.gs.washington.edu/data/muc1/'. |
| Source Db |
UniProtKB: locus MUC1_HUMAN, accession P15941;; class: standard.; extra accessions:A5YRV1,A6ZID9,A6ZIE0,B1AVQ8,B1AVR0,B6ECA1,E7ESE5,E7EUG9,P13931,P15942,P17626,Q0VAP5,Q0VAP6,Q14128,Q14876,Q16437,Q16442,Q16615,Q6S4Y3,Q7Z547,Q7Z548,Q7Z550,Q7Z552,Q9BXA4,Q9UE75,Q9UE76,Q9UQL1,Q9Y4J2; created: Apr 1, 1990.; sequence updated: May 18, 2010.; annotation updated: Oct 12, 2022.; xrefs: J05582.1, AAA60019.1, M32738.1, AAA35804.1, M32739.1, AAA35806.1, M34089.1, AAA35807.1, M34088.1, AAA35805.1, J05581.1, AAA59876.1, M61170.2, AAB53150.1, X52229.1, CAA36478.1, X52228.1, CAA36477.1, M35093.1, AAB59612.1, X80761.1, CAA56734.1, U60259.1, AAD10856.1, U60260.1, AAD10857.1, U60261.1, AAD10858.1, AF125525.1, AAD27842.1, AY466157.1, AAR28764.1, AY327582.1, AAP97013.1, AY327584.1, AAP97015.1, AY327586.1, AAP97017.1, AY327587.1, AAP97018.1, EF583653.1, ABQ59628.1, EF670711.1, ABS01298.1, EF670712.1, ABS01299.1, FJ226040.1, ACI25172.1, FJ226047.1, ACI25179.1, AF348143.1, AAK30142.1, AY463543.1, AAR18816.1, AL713999.28, CH471121.2, EAW53116.1, EAW53117.1, EAW53118.1, EAW53119.1, BC120974.2, AAI20975.1, BC120975.2, AAI20976.1, Z17324.1, CAA78972.1, Z17325.1, CAA78973.1, M31823.1, AAA35757.1, S81781.1, AAD14376.1, S81736.1, AAD14369.1, M21868.1, AAA59874.1, A35175, NP_001018016.1, NP_001018017.1, NP_001037855.1, NP_001037856.1, NP_001037857.1, NP_001037858.1, NP_001191214.1, NP_001191215.1, NP_001191216.1, NP_001191217.1, NP_001191218.1, NP_001191219.1, NP_001191220.1, NP_001191221.1, NP_001191222.1, NP_001191223.1, NP_001191224.1, NP_001191225.1, NP_001191226.1, NP_002447.4, 1SM3_P, 2ACM_A, 2ACM_B, 2FO4_P, 5T6P_E, 5T6P_F, 5T78_E, 5T78_F, 6FZQ_P, 6FZR_P, 6KX1_C, 6TGG_P, 7Q4I_F, 7Q4I_G; xrefs (non-sequence databases): CCDS:CCDS1098.1, CCDS:CCDS30882.1, CCDS:CCDS30883.1, CCDS:CCDS41408.1, CCDS:CCDS41409.1, CCDS:CCDS55641.1, CCDS:CCDS55642.1, PDBsum:1SM3, PDBsum:2ACM, PDBsum:2FO4, PDBsum:5T6P, PDBsum:5T78, PDBsum:6FZQ, PDBsum:6FZR, PDBsum:6KX1, PDBsum:6TGG, PDBsum:7Q4I, AlphaFoldDB:P15941, SMR:P15941, BioGRID:110669, DIP:DIP-41890N, IntAct:P15941, MINT:P15941, STRING:9606.ENSP00000484824, ChEMBL:CHEMBL3580494, DrugBank:DB11090, DrugBank:DB06584, MEROPS:S71.001, GlyConnect:372, GlyConnect:373, GlyConnect:374, GlyConnect:375, GlyConnect:376, GlyConnect:377, GlyConnect:413, GlyGen:P15941, iPTMnet:P15941, PhosphoSitePlus:P15941, SwissPalm:P15941, BioMuta:MUC1, DMDM:296439295, CPTAC:CPTAC-146, CPTAC:CPTAC-147, CPTAC:CPTAC-719, CPTAC:CPTAC-730, EPD:P15941, jPOST:P15941, MassIVE:P15941, MaxQB:P15941, PaxDb:P15941, PeptideAtlas:P15941, PRIDE:P15941, ProteomicsDB:1779, ProteomicsDB:53249, ProteomicsDB:53250, ProteomicsDB:53251, ProteomicsDB:53252, ProteomicsDB:53253, ProteomicsDB:53254, ProteomicsDB:53255, ProteomicsDB:53256, ProteomicsDB:53257, ProteomicsDB:53258, ProteomicsDB:58806, ProteomicsDB:6245, ProteomicsDB:69255, ProteomicsDB:69256, ProteomicsDB:767, ABCD:P15941, Antibodypedia:1298, CPTC:P15941, DNASU:4582, Ensembl:ENST00000337604.6, Ensembl:ENSP00000338983.5, Ensembl:ENSG00000185499.17, Ensembl:ENST00000342482.8, Ensembl:ENSP00000342814.4, Ensembl:ENST00000343256.9, Ensembl:ENSP00000339690.5, Ensembl:ENST00000368389.6, Ensembl:ENSP00000357374.2, Ensembl:ENST00000368390.7, Ensembl:ENSP00000357375.3, Ensembl:ENST00000368392.7, Ensembl:ENSP00000357377.3, Ensembl:ENST00000368393.7, Ensembl:ENSP00000357378.3, Ensembl:ENST00000368396.8, Ensembl:ENSP00000357381.4, Ensembl:ENST00000368398.7, Ensembl:ENSP00000357383.3, GeneID:4582, KEGG:hsa:4582, UCSC:uc001fia.4, CTD:4582, DisGeNET:4582, GeneCards:MUC1, GeneReviews:MUC1, HGNC:7508, HPA:ENSG00000185499, MalaCards:MUC1, MIM:113720, MIM:158340, MIM:174000, neXtProt:NX_P15941, OpenTargets:ENSG00000185499, Orphanet:88949, PharmGKB:PA31309, VEuPathDB:HostDB:ENSG00000185499, eggNOG:ENOG502QWCT, GeneTree:ENSGT00710000106874, HOGENOM:CLU_1386987_0_0_1, InParanoid:P15941, OrthoDB:945460at2759, PhylomeDB:P15941, PathwayCommons:P15941, Reactome:R-HSA-5083625, Reactome:R-HSA-5083632, Reactome:R-HSA-5083636, Reactome:R-HSA-5621480, Reactome:R-HSA-6785807, Reactome:R-HSA-913709, Reactome:R-HSA-977068, SignaLink:P15941, SIGNOR:P15941, BioGRID-ORCS:4582, ChiTaRS:MUC1, EvolutionaryTrace:P15941, GeneWiki:MUC1, GenomeRNAi:4582, Pharos:P15941, PRO:PR:P15941, Proteomes:UP000005640, RNAct:P15941, Bgee:ENSG00000185499, ExpressionAtlas:P15941, Genevisible:P15941, GO:0016324, GO:0000785, GO:0070062, GO:0005615, GO:0005796, GO:0005887, GO:0005634, GO:0005886, GO:0031982, GO:0002039, GO:0000978, GO:0003712, GO:0006977, GO:0006978, GO:0051179, GO:0033629, GO:1902166, GO:0010944, GO:0090240, GO:0036003, GO:0043618, DisProt:DP01790, Gene3D:6.10.140.600, IDEAL:IID00195, InterPro:IPR000082, InterPro:IPR036364, Pfam:PF01390, SMART:SM00200, SUPFAM:SSF82671, PROSITE:PS50024 |
| Sequence |
mtpgtqspffllllltvltvvtgsghasstpggeketsatqrssvpssteknavsmtssvlsshspgsgssttqgqdvtlapatepasgsaatwgqdvtsvpvtrpalgsttppahdvtsapdnkpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdtrpapgstappahgvtsapdnrpalgstappvhnvtsasgsasgsastlvhngtsaratttpaskstpfsipshhsdtpttlashstktdassthhssvppltssnhstspqlstgvsffflsfhisnlqfnssledpstdyyqelqrdisemflqiykqggflglsnikfrpgsvvvqltlafregtinvhdvetqfnqykteaasrynltisdvsvsdvpfpfsaqsgagvpgwgiallvlvcvlvalaivylialavcqcrrknygqldifpardtyhpmseyptyhthgryvppsstdrspyekvsagnggsslsytnpavaatsanl |
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