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| Record Information |
| Record ID |
44 |
| Pubmed ID |
31876334 |
| SNP |
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| Gene ID |
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| Protein ID |
P06731 |
| Vaccine Adverse Events |
depressed level of consciousness associated with fever, fatigue, chills |
| Vaccine |
BN-Brachyury vaccine |
| Gene Name |
|
| Official Symbol |
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| Aliases |
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| Other Designations |
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| Chromosome |
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| Location |
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| Annotation |
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| MIM |
|
| DNA Sequence |
|
| Protein Name |
CEAM5_HUMAN |
| Length |
702 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-JAN-1988 |
| Definition |
RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 5; AltName: Full=Carcinoembryonic antigen; Short=CEA; AltName: Full=Meconium antigen 100; AltName: CD_antigen=CD66e; Flags: Precursor |
| Primary Accession |
P06731 |
| Accession Version |
P06731.4 |
| Other SeqIDs |
sp|P06731.4|CEAM5_HUMAN,gi|2203400805 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Mar 4, 2022 this sequence version replaced P06731.3.; [FUNCTION] Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}.; [FUNCTION] (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.; [SUBUNIT] Homodimer. {ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:26483485}.; [INTERACTION] P06731; P06731: CEACAM5; NbExp=7; IntAct=EBI-3914938, EBI-3914938; P06731; K0BRG7: S; Xeno; NbExp=4; IntAct=EBI-3914938, EBI-16040613.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06731-1; Sequence=Displayed; Name=2; IsoId=P06731-2; Sequence=VSP_053414.; [TISSUE SPECIFICITY] Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. {ECO:0000269|PubMed:10436421}.; [PTM] Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.; [SIMILARITY] Belongs to the immunoglobulin superfamily. CEA family. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=AAA62835.1; Type=Frameshift; Evidence={ECO:0000305}. |
| Source Db |
UniProtKB: locus CEAM5_HUMAN, accession P06731;; class: standard.; extra accessions:H9KVA7; created: Jan 1, 1988.; sequence updated: Feb 23, 2022.; annotation updated: Oct 12, 2022.; xrefs: M17303.1, AAB59513.1, M29540.1, AAA51967.1, M59262.1, AAA62835.1, M59255.1, M59256.1, M59257.1, M59258.1, M59259.1, M59260.1, M59261.1, M59709.1, M59710.1, AC243967.3, X16455.1, CAA34474.1, M15042.1, AAA51963.1, M16234.1, AAA51972.1, A36319, NP_001278413.1, NP_001295327.1, NP_004354.3, 1E07_A, 2QSQ_A, 2QSQ_B, 2QST_A, 2QST_B, 2VER_N; xrefs (non-sequence databases): CCDS:CCDS12584.1, CCDS:CCDS77302.1, PDBsum:1E07, PDBsum:2QSQ, PDBsum:2QST, PDBsum:2VER, AlphaFoldDB:P06731, SMR:P06731, BioGRID:107478, DIP:DIP-57769N, IntAct:P06731, MINT:P06731, STRING:9606.ENSP00000221992, ChEMBL:CHEMBL3712881, DrugBank:DB05097, DrugBank:DB08217, GlyConnect:1071, GlyGen:P06731, iPTMnet:P06731, PhosphoSitePlus:P06731, BioMuta:CEACAM5, DMDM:317373456, jPOST:P06731, MassIVE:P06731, MaxQB:P06731, PaxDb:P06731, PeptideAtlas:P06731, PRIDE:P06731, ProteomicsDB:46254, ProteomicsDB:51917, ABCD:P06731, Antibodypedia:3500, DNASU:1048, Ensembl:ENST00000221992.11, Ensembl:ENSP00000221992.5, Ensembl:ENSG00000105388.17, Ensembl:ENST00000398599.8, Ensembl:ENSP00000381600.4, Ensembl:ENST00000405816.5, Ensembl:ENSP00000385072.1, Ensembl:ENST00000617332.4, Ensembl:ENSP00000482303.1, GeneID:1048, KEGG:hsa:1048, MANE-Select:ENST00000221992.11, UCSC:uc002orj.2, CTD:1048, DisGeNET:1048, GeneCards:CEACAM5, HGNC:1817, HPA:ENSG00000105388, MIM:114890, neXtProt:NX_P06731, OpenTargets:ENSG00000105388, PharmGKB:PA26361, VEuPathDB:HostDB:ENSG00000105388, eggNOG:ENOG502RXPD, GeneTree:ENSGT00960000186634, HOGENOM:CLU_024555_7_0_1, InParanoid:P06731, OrthoDB:998214at2759, PhylomeDB:P06731, TreeFam:TF336859, PathwayCommons:P06731, Reactome:R-HSA-163125, Reactome:R-HSA-202733, SignaLink:P06731, BioGRID-ORCS:1048, ChiTaRS:CEACAM5, EvolutionaryTrace:P06731, GeneWiki:CEACAM5, GenomeRNAi:1048, Pharos:P06731, PRO:PR:P06731, Proteomes:UP000005640, RNAct:P06731, Bgee:ENSG00000105388, ExpressionAtlas:P06731, Genevisible:P06731, GO:0031225, GO:0016324, GO:0016323, GO:0009986, GO:0070062, GO:0005576, GO:0005887, GO:0005886, GO:0034235, GO:0042802, GO:0042803, GO:0006915, GO:0007157, GO:0007156, GO:0034109, GO:2000811, GO:0043066, GO:0010832, Gene3D:2.60.40.10, InterPro:IPR007110, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003599, InterPro:IPR003598, InterPro:IPR013106, Pfam:PF13895, Pfam:PF07686, SMART:SM00409, SMART:SM00408, SUPFAM:SSF48726, PROSITE:PS50835 |
| Sequence |
mespsapphrwcipwqrllltaslltfwnppttakltiestpfnvaegkevlllvhnlpqhlfgyswykgervdgnrqiigyvigtqqatpgpaysgreiiypnaslliqniiqndtgfytlhviksdlvneeatgqfrvypelpkpsissnnskpvedkdavaftcepetqdatylwwvnnqslpvsprlqlsngnrtltlfnvtrndtasykcetqnpvsarrsdsvilnvlygpdaptisplntsyrsgenlnlschaasnppaqyswfvngtfqqstqelfipnitvnnsgsytcqahnsdtglnrttvttitvyaeppkpfitsnnsnpvededavaltcepeiqnttylwwvnnqslpvsprlqlsndnrtltllsvtrndvgpyecgiqnelsvdhsdpvilnvlygpddptispsytyyrpgvnlslschaasnppaqyswlidgniqqhtqelfisniteknsglytcqannsasghsrttvktitvsaelpkpsissnnskpvedkdavaftcepeaqnttylwwvngqslpvsprlqlsngnrtltlfnvtrndarayvcgiqnsvsanrsdpvtldvlygpdtpiisppdssylsganlnlschsasnpspqyswringipqqhtqvlfiakitpnnngtyacfvsnlatgrnnsivksitvsasgtspglsagatvgimigvlvgvali |
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