|
|
| Record Information |
| Record ID |
35 |
| Pubmed ID |
32500232 |
| SNP |
|
| Gene ID |
29126 |
| Protein ID |
Q9NZQ7 |
| Vaccine Adverse Events |
injection site reactions, eosinophilic pneumonia, influenza-like symptoms and anaphylactic reactions. |
| Vaccine |
esophageal cancer peptide vaccine |
| Gene Name |
CD274 |
| Official Symbol |
CD274 molecule [Homo sapiens (human)] |
| Aliases |
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1 |
| Other Designations |
programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1 |
| Chromosome |
9 |
| Location |
9p24.1 |
| Annotation |
Chromosome 9 NC_000009.12 (5450542..5470554) |
| MIM |
605402 |
| DNA Sequence |
>NC_000009.12:5450542-5470554 Homo sapiens chromosome 9, GRCh38.p14 Primary Assembly
AGTTCTGCGCAGCTTCCCGAGGCTCCGCACCAGCCGCGCTTCTGTCCGCCTGCAGGTAGGGAGCGTTGTT
CCTCCGCGGGTGCCCACGGCCCAGTATCTCTGGCTAGCTCGCTGGGCACTTTAGGACGGAGGGTCTCTAC
ACCCTTTCTTTGGGATGGAGAGAGGAGAAGGGAAAGGGAACGCGATGGTCTAGGGGGCAGTAGAGCCAAT
TACCTGTTGGGGTTAATAAGAACAGGCAATGCATCTGGCCTTCCTCCAGGCGCGATTCAGTTTTGCTCTA
AAAATAATTTATACCTCTAAAAATAAATAAGATAGGTAGTATAGGATAGGTAGTCATTCTTATGCGACTG
TGTGTTCAGAATATAGCTCTGATGCTAGGCTGGAGGTCTGGACACGGGTCCAAGTCCACCGCCAGCTGCT
TGCTAGTAACATGACTTGTGTAAGTTATCCCAGCTGCAGCATCTAAGTAAGTCTCTTCCTGCGCTAAGCA
GGTCCAGGATCCCTGAACGGAATTTATTTGCTCTGTCCATTCTGAGAACCCAAAGGAGTCCTAAAAGAGG
AATGGAGGAGCCTAAGAATAAAAATAGTATAATAAAACATTTCTTAGACACATTGACCTTGGCCTATGTC
AAAGTTCAGTCTGGGTTTGTCTTATAACACAAGGAGTAAAAGTACCATTGTTCTACCTCTTTTTTTAATA
CTTGAAAAAAATTTACTGTGGATGCTTTTCTATGAATTAAATAACCTTCTAAAAAATGTTTTCATTGCTG
CATTCGATTAGATTGGGTAACTAAATGAAATTAATTCCTCACTGTTGGGTATAAAGGTTATTTACAGTGG
TTCTGTCTTAGCCATTCACTGAACTCATTGCATATATATCTCTGGAATATTGCTGATTGTTTCCTTCAAG
TAAACTTAGAAGTGTAACTACTTAGTCAAAGAGCCTGAATATTTTAAAGGCCTTTTGAAGAAAACTGAAA
ATGCTTTCCAGAAAGGATGTATCAGTTGACAATGACAGTCGTCAACAGTATTTAAGGAGAACTATGATAC
TCTGAAGAAAAACTTAGCCTTTCTCAGTAAAAGTAGGTAGGCAGAGGCCACATGACAGCAGTTAGAGTGT
GGTCTTCAAGGAAGTCACAGAAATACTGTGGGGAATTGAAACCCCATGTGGAAAATGTACAAGAGTGTCT
CAGTGTGACTGAGAAGGAGGTTGGGCATGGGGTTTCATGGAGTTTAATAAAGTTTGGTCACTTAGTAGAG
GTTTAATAAATCAACTGTCTTAATCTTTGATCCTACTTAAGAATTTTTTTTTTGTTTTTGTAGAGATGGG
GCTCTTGTTATGTTGCCCAGGCTGTTCTCGAACTCCTAGCCTCAGGCGATCCTCCCTCCTCAGGCTCCAG
AAGTCCTGGGATTACTGGCGGGAGCCACCATGCAGGCCTCTTGCTCCTACTTTTGAGAAAGGAAGTTTAA
CCGGTTTTTTTTGTCTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCCCATGCTGGAGTGCA
GTGGTGCAATCTCAGCTCACTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGG
GACTACAGGCACCTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAAATGGGGTTTCACCATATT
GGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTA
CAGGCATGAGCCACTGCTCCTGGCTGCTTAACTTTTTCTCTATCTCATCCTCCTACCCATCCTACCCTTG
GAAGATAGAGAAGTAGTATTAGTTCCATAGTGTTATACTGGGCTTCCCCCAGGGACAAACCCACTTCCCC
AACCTGAATGAGCCATCACTTCTTCCCCAGTTTACATTTCATTGCTCTTTAAATGTCTCCATTCGGATAT
GGGAATTCACATATGGTCATAATTCTTACCTGAAGAAGATGTCAGTCTTCTTCTCTTAGACCAACTGCCC
TGATATGAGGTTTAGAGGTTAAAGAACATGTGTGTATTTACATGATCTTTGTATTCTGCCTTTTCGTCCC
TCACTAATGACAGCTGCACCCCAAGGAAATGGAGCTGTGGAAGAGAGGGTTTGATAAGAAATTAAGTAAA
TATTGGATCTAATCCATCACCCTCCAGGAAGCCTTTATTACTCCTAAAAATTTCAACCAAATTCATTAAA
GGACAAGAACTCCACCAGAGTAGGCCATAAACATTGGCAAAATTAGTTGTAATCCATGACTAGATTTAAT
GTCCCTTTGTTTTATTCCCATATGGTTATAATGCTTTGCTTGGCATTAGGGGTATTTTAAGTTTTCTTCT
GCCTAGTAAGTGAATTTGTGTTTATAATACAATAATCATAAAATATCACATTAATATTTTATAACTGTAC
AGTTATAAAATATTTTATAAGTAATATTTATATTTTATAAGTAATATTTTATAACTGTACAGTTAACTCT
GGCCCAAGGAAAAGATAGTCTGATAGATGCTGCAGCCCCATTTTAGCAAATGTGACCTCACAGGCCTGAA
TGCCATCGCTATTCCACATCTACAGGATAGACGGAAAGGAAAGAAATAAAAAAATAGGTACCTAACACTG
GCAAGAGGATGATGACTCATGTTATTTCACTTAACCTTTTTATCTTTTAACATGAAGGACTCATACAGGT
TGATAAGAAACCAGTGACATAAACAGACCAAAAAATGATCAGATCTTTCAAATTAGCAAAAAAATAATAT
TTTTTAAACAATGGGTGAAAATACAGTGTAACAGTACCAATTATCAACATGTGTTGAGAACCAGAAAAAT
GTTCTTTTTCTTTGATCAGCAACACTATTTGGGAAAATCTATCCTCAGGGCCTAGCCTGGGGCCCTGGCA
CACAGTAGGCACTCAACGAATATTTGCTGAACACACAAATACTTATGATATTTTAAAAAATTGGCAACAA
TCTGATACCTAACAATAGAGGGATTAAATATTATGGAACTGTTAAATAAGATGCTTATGAATACCATGCA
GTAAGATGGGCAATATTTATGCCATAAGCTTTAATGAAACAAATGGGTATTAAATGTATGATAAGGTTAT
AAATTACTTTTTAAAAGATTACAGGGAAAAAAATTGAAAGATATACACTGAAATGTTTTTTGCTCACAGT
GGTGACAAGGTTTCTCAGCACTGGCACTGTTGACGTTTTAGGCTGTATGTCTTTGCTGTGGGAGGCTGGC
CTGTGCACTGCAGGGTGTTTGGCAGCACTCTTGGCCTCTGCCCCTAGATAGCAATAGCAGTCCTCCCTCA
ACCAGCCCAATTTTGACAACCAAAAATGTTTCCAGGCATCACCAGATGCTCCCTGGGTGAGAGTGATGAA
ATAGTAGGGGATTTTCCCCTTCTTTTCTTATTTTCTGTAATTCCATTATATTACTTTAATAATAAAGAAA
AAAACATAAAAAATAAACGAATGTTATTATTCTACGTCAGTTTGGATGTTTGGACTCCATTTTGGGGTTC
TTTCCATTATATCACTTGGTCTGCTAAACATTCTACGGTTTGGTAAGGTGAAGTGATTCATGAAATTTTG
GTTTTATTTTTTTCCTGATACTAAAAATAAAACATTCTTTCACTTGGAAATTTGGACACAGAACACCAAA
AAAAATCCATAATCTCATCTCTCTTTTTCTGTCTTTTCCTTCCTTTTTTCCCTTTAAAAACAATAAAGAG
TGAAACCTACCTGTTCTCCCTCTAATTTAATTCCTAAATATAATCACTGTCAATATCTTGGACATTTCCT
GTGTCTAAACACACACACACACTTTTTTTTTTCAGCAAAAGTGGATTTCTGCTACATGTAGTGTTCTGCA
ACTTACTTTCTATGTGTTTACAAAATCAGTACATGTACATATGCTGAATTCAGTCCTTAATGGTATTATA
TTTTGTGAATATACCAAAATTTGTTTAACCACTTAGACAATCTAGGATATTCTCAGTTTGCTGTTATGAG
CAATGCTCTTCCTTTACATATACAGACATATATATATATATGTGTGTGTGTGTGTTTTTGTTTTAGTAGG
ATAGATTTCTAGGAGAGGGTGAAAGGTCTTATGACATCCGCATTTACGATTGTAATAGGAAGTATCAAAG
TGCCCCCTAAAGAAAAAAATCCTCCCATTAGTGGGTAAGAAAGCCTATTTGTTCATATCTTCACAAACAC
TAAATATTAGAAATATTTACAATTGTGGTCAAGCTCATAAGTGAAAATGGTATTTCATATCTTATATTTT
TTATTGTGAGATTGAACATCTTTCATATGTTTACATGTCACCTGTATTTCTTATTCTCTGAACTATATGT
TATGACCTTTCACTTTTTTTCCTCATGGGTTATGTGTAGTTTGTATAGTTGTCTTATTGATTGTTAGGAG
CTATTTATATATTAGGAACATTAATCTCCTGTCTTATATATACGTGGCATCGATTAGTTGATCATTTGTG
AGTTCATGTCTGTATACAAAGATTGGAGAGGCACTAAGAGGGAAAACTTACCTCTTTCTTATCAAAGTTT
GTAAATATATGTATAACAGAAGAGGGAGAAAATATTAATAAATGCACAGATTGGCTGAAATAGAGTATAA
ATCTTTTACTCCCCTACTTCAACATAAACTGCAAAAGGAGAGTGACTTTTCTTTCACTCTGACTTCCGTA
TTCCTCATGCTTAAAATAGTGCCTAGCACAGAAGAGGTGCTCAATCAGTGTTTGCTAAACGAAATAATTA
GTCACATTTCAAGCAGGATGACTAAATGAAGAATAGAATCTAGGCAGATACTCTGGAAGAGTGGCTGTGA
GTCATTCATATCTTAGTATGAATTAGTCAAATCCAACTCTCTCCCCTTCCCACTCCCCACTGTTAGTAGA
AGAATCTGTTTATTGAGAGAATAGATTTATAATTTAGAATAAGTGAGAGGGGCAGAAGAGGAGATTTTGA
AGGATGGCACCTGAAGGAGGACTAGCATGGCTGAGACAGTGAAGTGGAAGCCTTGAATAGCTAAAGGGTA
AGATGAAAGTATTTAGCTGTAGGGGGAAAAAGCATTGACAGGTTGGAAAAGTAAAAGTCAGATTCTCCTT
GCTCTGAAATTTTGTACAGGGCAGGTTCTACTAGGTATGTTACAATGCAGAAAAAACATGAAATAATTGA
GAGGAATTTGGTGCAATATTATCTTCTTGGCTTCTTTTGAGTGGGCAGATTTTTTTCACGGCCTGTAACT
ATAATAAATTTGAAACTTCTCATCTTTTAGTAACTTTTTTCACTTAAGTTTATGTGGCTGTGGGCAATGG
AATGAAGATATTGAACTTCCAATTCCCTGTTGGGTTTCCACAATTACAAGTCAATCATGACTGGTTATTA
GAAGACTATTTCAGTTAGAACCACCAAGTCCCATATTGTCATATTGTATGTTTAATTATTAAGTGAAGCA
GTCTTCTTTTCGTGTTTTCCATAATTAGGGCATTCCAGAAAGATGAGGATATTTGCTGTCTTTATATTCA
TGACCTACTGGCATTTGCTGAACGGTAAGACACCAAATCCTTCCATTAGGTTCTATATTTTAAATATTTT
AACCATGAGTTTAAAACTAAAATGATCATTTAAAATGCATGCAATTTTCTTATAGAGAGAACATTCTATT
CTTTCTTCTACTTTACACAATGGCAAAGTCTTCTTTCTACTTTACGCAATGATAAAGTTACCTGTGTCAT
TTTGTAAAAATATAGAGAATATAGACAAATTGAAAGACACAAAATAATCTATTACCCATTTCCCAGGGTT
AACTACTGAAAATATCTGGGGAAATGGCCTGTATGTATACATTTATTTGTTTGCTTTCAACAAGGCCAAG
ATCCTTTGATCTTTCAGTCTTGGTTGCTCTGTGACATGCCTTTCCTGATGAGGATACTTTAAGGAAGAAT
TGTAAGATACATGGAAAATGTCAGGCTAACACAGTACTGGCATCACCCTGTGCTCTTTCCTGAACTCCAT
ACCAATGTACTTCTTGCCAGAAAACTGATCAAAAGTTTAGGGAAGTAAAAAGAGATGACTGTTAGAATCT
ACCATTCCCTCTATGTAGGAAGCAAATAGGTGTCCTGTCAAAGGACATTCTGGGGATGTCTACATGAAAC
CAAGTCTCCCTGGTTGTAAGGACTCCATCTCCATATAATATTTATACAGTAATATATGTTTATAAATTGT
GGGGGCAACTTGTTTAGCTAATTTTATTATTCTGCTATTGGGACACTGTGTCTCAGCATGAGATATAGTG
TCCCAAAACATATTTCAAGCCCATTGGATAAAATATGTGTTTAGCAAGTTCTTAAATATAATGATAACAT
AACCGACCAGATAAAGTGATTTATAAACGCTGTGCCAATTTTGTAAATGTTTCGAGGAATTTTCCCTTTT
CTGAAGATTGTCCTTCTTTCTTTTTAGCATTTACTGTCACGGTTCCCAAGGACCTATATGTGGTAGAGTA
TGGTAGCAATATGACAATTGAATGCAAATTCCCAGTAGAAAAACAATTAGACCTGGCTGCACTAATTGTC
TATTGGGAAATGGAGGATAAGAACATTATTCAATTTGTGCATGGAGAGGAAGACCTGAAGGTTCAGCATA
GTAGCTACAGACAGAGGGCCCGGCTGTTGAAGGACCAGCTCTCCCTGGGAAATGCTGCACTTCAGATCAC
AGATGTGAAATTGCAGGATGCAGGGGTGTACCGCTGCATGATCAGCTATGGTGGTGCCGACTACAAGCGA
ATTACTGTGAAAGTCAATGGTAAGAATTATTATAGATGAGAGGCCTGATCTTTATTGAAAACATATTCCA
AGTGTTGAAGACTTTTCATTCTTGTAAGTCCATACTTATTTTCAAACAGAACAGCATAGTCTGTTCATTC
ATTCATTCAATTCATGAATTCATTCACATAATTATCCAATTTCTTGAGCACCTATTTGATAGTCACTGGA
AATCCAGAGACAAACAACACAGAGCCATGTTCTACAGTATGTACAGTTTTCCAAAAAGAATTTCTAGTCT
TTACTTTTTTATTACAAATGGAATACGTATACTTGCAAATAATTCAGATACTGTGGAAGAGATCAAATGA
ATTGCAAAAGTGTCCCTCCTCCCTTCACCACTATCTCCCATGGCATGCAGAGAGAGTAACCATTATTTGT
GTGTCCCTCCAGAAATTTTTTTATTCAACTACTATTTTTTTATTTTATTAGGTCCGTCAGTTTTCCTTTT
TTGAGCCTCTCTATATCAAATGCAAATAAATATATTCAGAACAAACCCCACTGTAAGGTTCACATTAAAA
AAGACTTGAAGTCACCCTATGAAGACAAAAAATAATCACATTAAGTGTGAAAGAACCTATTCTTCCAGTA
CAGGATAAGCCATACTTACTGGGCATATATTCATCTTGAAAATCTATACTGATGTTGTCTTGGGGAATTG
AAAAGGAACTAGGAGTGTTAGTTCCTCGGTATTGACCCACAGTTATGTTATCAGGTCACTTGAGTTCAAA
GTTTTGTGTTGGCACTAGCTAAGTAAAGGAAAACACCTCTGCTTTCATTGTTGAGTTTCACAGAATTGAG
AGCTGAAAGGATCCCAGGCAGGAGCAGCTAATCCAAACTCCCACAAAGAACAAAAATCCCCCAGAGGATC
TTCTGTTCTTATATTTCCTGCAATGGCGTCCCTGTCATATCCCACAATGGCCTCCCTGCCATTTGGATAT
CCCTTCCATATCCTGTTGAAATTACTCCCTAATAGTAAGCTGAAATCTGCCCCTCTAGTTGTAGTCTTGG
GATTATTTCATTTACATGATGACCTTTTAATATTTGACTAGAATTAAATCATCTCCCCTTGGTCTTTCCA
TTCCTGGGCTAACTACCATCAATCTGAGGGCTAACAATACAAGTAGAAAAAGTATACATTTGTCACTGAT
CACTGATCAATTATTAATCAATGATCACTGATAACTATAAACTCAAAAACAAAATCATGTGGGGATTAAG
AGAAATGTATCAGTTTTATGTTGTATTTCTGGTCCCTGATACTGGCTCAGGTAATGCCACTATTGTCAAG
AAGATACCACTTGTAAAGTAGATTTAATTTTCATTATATTTTACCATATGCTTCTCCATTCATGACATCT
CTTGAGATGTTGTGGTTTATACTTTCAGTTTTTCTCCAGTCCATCCGCAAATATCAGGCATCTACTGTGT
TCCAAGATATTAAAGAAATCATCATGACTTAGCCTCATCAACAGCATTGCTAGATCTGGGATGGAAAGGA
AGAGTATAATCCTGGCAGTCAGGAAGAAGGCAGCATAAAGTATAAGTTTCTGCTTCCAAAAAAGGTCTCT
CATCAGCCTGTAGGGAGTGTGTAGGGAAGGGACAGCTGTCCTTGTAGTAGGGAAGGGTTTTATTCAGGTC
GTCTGGGCTCCATAATATCCCTTGTGTATCTGCAGTCTCCTTTGCCATGGATCAACACAATAGGAAATCT
TCCGGCACTGATGGTTTTTCCAAGGGGGAGTTCTTCCTGGAGCAAAGCAAATGACCAACCAGGTTTGAGG
ACCTGATTTGTTTGACAATTCCATTTTGTATTGTAAATTACTTAATTGGCATTCTACTCCCAATCCATCT
TGTCATTTGCATACAGTGGTTTTGGGATTGAGTTCAGCTATACCAAAAGTCTGAACCTTCTGCACTTAGA
ACAAGGCAACCACCAAGCTTCACTTGCACTGAGGCCGTGTCTCCAATGGAAATGAGGCAGCTGGCTTGCA
GGAGCTTCCCAACTCAGGGAAGTAGAACTCCTGAGTCACCTCCATATGCAAATGATTTCACAGTAATGCT
GTTGAACTTCACTTCCCATCACAGCAAATGTGTGGTAACATAGCTTCCCCACAGGAGTTTACTCACCATG
GTATTTTAAAGGTGAAACATTTCAAAACTGAAATTTGAAAGAATTTAGTTTTGGATTCACTCAATTATCA
CTATCACTTCGGGTGTTATTGCACCTTTCTTGTTTGTGAGTTTAAATGCCAGACTCTCAGGCCACTAACT
TTCAATTAAAAGTGTTTTTCTTTAATCGCTGAACCTAACAGCAGGGAAAACGAAATGTTCATTCAGACTT
TCAGAACCTTCAATGAGATTAGGCAGCTGAAAGATCAAAGTGTTGCATAGTTGTCCCGATAAAGCTATTT
GGATCATATGGACCAAATCGACTGCTGTCATTCCCCACCAACCCCATCTCTCCCCAAAATTCCCAGCCCT
GTTTAAGTGTTCTCTGTAGCATTTATCTCTATCTAGTATATTGTGTAGCATATCATATCATACTTTTCTG
TTTTGTTTATTGTCTCTCTCCTCCTAGAATATAAACTCCACAAGCACAAAGATTTGGGCCTGTTTTATAA
TATTGTTGCATCCCCAGGGCCTGATATACAGCAGAGTGGTGGTACGAAAAGAGCACACAAAAAAATATTT
GTTGAGTCAATGAATGAATGATTTCCTCAAATAGGATTAGCCTAAAATTTTGGAAACATGAACAGATTTG
GATATGTGAAAATTTATTTCCAGACTGTTCATCAGGAACTGTTAGCAGCTTCTAAAGGGTACACTGGAGC
AGCAGTAGTAAAAGGAGGAAGAGGAGCAGCTCTGCTACTGCTACTATCGAGTACTACTACAATTAGCACT
TGCTTATTCTGTGTGTTAGGCCCTGTACTGAACACTCTGTCTAAATTAGTTCATTTCCTCCTGGAAATGA
CTCTAGGGGGTAAGTGCTTCATCATGTAAGATGAGTATTTTTCACATTTTGTTGTGTCTGAAATCTGAGT
GTGTCTTTCAATGATGGAATCTTTGATTCCATGATAAGTGGTATTATTCCCATTTTAAGGATGAGGAAAC
TGAGGTCCAAAGAAATTAAGTAATTTGCCCAAATTCACCCAGCCTAGAAAATGATAAAGCTAGTTCTAAA
CCCAAGCAGATTAGCTCTGAAGTCTGGGCCCTTAATAACCACTTTTTATTGCCTATATTTGTACCTCTGG
TGTACGTATCAAGTTATATGTTGACTTCAAAACTATCATGACCTTTTCTTGGTTTTGATTGTCCAACATT
AGTATAGTGTTCTGGGTCTGCAAAAATTTTGATTACTCATCTCATCTGTAAAACATTTTGAACTCGTGTG
TTTGTGCATGCACATTTGTGTGTAATTATAAAAATTTTACTTTCTGTTAATATATAAGTTGTATCATAAG
AAACTGCCGTTTTTGAAGAGCAAAAAAAGGTTGAATGTTACCAGTTACATCTGGTTCAACCTAATAGACA
TTTGTACAAAAACAGACATTTTAAGAGGTTGAAATAAAAATTTAATAAACAATATTTTCAGTTTTTACTA
ATTGTGATGCTTCACTATCATTAGCTAATATGTCAAGGCATAATATACCTTAGGGTGAACTTTATCATTA
ACAAAGGTGGATGGTGTCAATAATCTTGAGGTTTGTGTTTTTTTATATAACACTGCGAGGTCTAATTAAG
TACTTACTGTTTACCACCTCATACAGTGGCCGATAAAAAGTGTCACTTCTGCTGTTTCCTCTGGGTTGTG
CTTGAATTATTAGTATTATCTTCAGTCCTCAGTTTCTTTGTGGGAAACTTTTTAATTAGTTGTTTAATTT
TGTAAGATGGTTAGTTTAGTCAAAATTAGATAAGAGAATTTGAAAATCCGTAGCTACCCCAAAGCAACCT
ACACATAAGAACTATTATTTTTGTGTTTTGAAATCATAATTTTATTGATTTCCAGTGTTTCCACTGGTAG
TGGTTTCATTGATATAGGAGTATCAAAACATCACTCATTATTTATTTCAGTTTCATTTGATCCTAGCCGT
TTTGTATTAACTCTCTGTGAAGAAATTACCTCACAAATCTATTGCTGTCCTTGGTAAAGGAATGGAGAAT
TAAGGCTCTAGATCATTAGTGGTTACACTATAGTATTAGAAGTAAAAAAAAGATTATACCAACAAAATAA
GAACATGTTAATGTACTTGTAATGAATAAACATGAATAAAGCTCTTATGCTATATAGGTGCACTAAACAA
TCTACTAGAATTGTCAGCAAACTACGTATCTTAATCCTGAAAGGGTCCCAAACCAATGATCTAAAATTGA
ATCAAACTTTCTTCCTTGAGCATAATTACTTAAATGATTTATTAAAATAGCCAGCATTTAAAAGCTTAAA
ATGTAAATATCATAATGTGGTATCCTAGATAGCATCCCAGAACAGAAAAAGGATATTAGGGAAAAACTGG
AGGAATGGAATAAATTATGCAGTTTAGTTATTAATAATGTACTAACGTCCTTAGTTATGACGATTGTACC
ATGGTAATGTAAGATACTAACAATAGAGGAAACCGGGTAAGGAGTATACAGTAACTCTATACTATCTTTG
CAACTTTTTTGTAAATTTAAAACTTCTAAAATAAAGAACAAATTTAAACATTAAAAAGTATCACCAGGAA
CATATATCACTGTTTACAGATGAAATACTATGTATTTTCATATCTAATTTCTGATCATTGACTTCAAATC
AGAAAAGTGAATGACACCTCAAAATCAGGTTTTCTGTTTACTGAAGTCTAAGAAAAGAAAGCATACCAGC
TGGAGAGATTCATGTTTATAAAGACAGATTTATAACAACAAAAATAAAATATCCAAGAATAAATTTAAGA
AGAAGCACTTTACTGAGAAACATATGAAAACCTGAACAAATGGAGAGGGATATTTTGTATTTGAATAGAA
AGACTTCTGGTTTAAAGATAATTCTCTTTAAATTATTTTTTGTAGAAATTTAAGGGGTACAAGAGCAGTG
TTGTCACATGGATATATTACATAGTGGTGAAGTCTGGGGTTTTAGTGTAAATTAATCTTTACATTTTGTT
TGAGCCCAATAAATGTACCAACATGATTTTTATAGAAAGATAGTCATTCCTATTAATCCAAACTTGTCCC
AACTTTGAATTGAATTGAGGCAGAGCTAGCAGGTGTTCCCCACGGCTGAGGCATCTGAACATTAAGCATA
TCCCTCTGAGAACCAGCCTGCATTGATACTCTTTCTAATGTGGACAGCATCAAGCTATGTACGTAGTTCT
GTGCTCAGCAAAAGCCCTGACTTCTTTTTGTTTATGTCCTAGCCCCATACAACAAAATCAACCAAAGAAT
TTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGACATGTCAGGCTGAGGGCTACCCCAAGGCCGAA
GTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGTGGTAAGACCACCACCACCAATTCCAAGAGAGAGG
AGAAGCTTTTCAATGTGACCAGCACACTGAGAATCAACACAACAACTAATGAGATTTTCTACTGCACTTT
TAGGAGATTAGATCCTGAGGAAAACCATACAGCTGAATTGGTCATCCCAGGTAATATTCTGAATGTGTCC
ATTAAAATATGTCTAACACTGTCCCCTAGCACCTAGCATGATGTCTGCCTATCATAGTCATTCAGTGATT
GTTGAATAAATGAATGAATGAATAACACTATGTTTACAAAATATATCCTAATTCCTCACCTCCATTCATC
CAAACCATATTGTTACTTAATAAACATTCAGCAGATATTTATGGAATATACCTTTTGTTCCATGCATTGT
AGTACTCATTGGATACACATAGAATAATAAGACTCAGTTCACACTCTTCAGGAAACAGATAAAAAACTAA
GAAACAAACAAAAAACAGGCAATCCAACACCATGTGGGAAATGCTTTCATAGCCGGGAAACCTGGGGAAT
ACCTGAGAGGAATACTCAATTCAGGCCTTGTTTCAGGAATCCAAATCCTGGCACATCAGAGCTGCTTCCC
TCTTTCCAGGGTGGCAGGAAATAAATGGAACATATTTTTCTATCTTATGCCAAACATGAGGGACCCTTTC
TCCCCGGTGCCTCTCCCAAGGTAGTCTACAATATTTCAACTCTAGCAGTCTGCTTAGTGCATAGAACATG
AGGCTGTGTGTCCCTGGGCAAATTACTAGACTTCTGTGTGCTTCACTTTCCCTGTAGGATTATAATCTAC
TGAGCAAGCTTATTGTAAGGGTCAGATTAGCAACAGTGTATGAAAATGATTTGAGACCATTGCCTGCACA
AATTCAACTATTTTTTTTTATCTCACTACTCTACAGAAGTAGGTAGGGTGGGAGACAGAGTCTGATGAGA
GGCTCAGAATGTGAAAGAAAGTGAGGCGAGTGAGCATGATATTTAATATAAACACAAAGATATTCTGAGA
AGAGCTGCTCACTGCCCCCTCCCCCAATACATGTTGATAGGAAAATGCCACGTACTTCAGCAAAAACAAC
TGAAAAATTAGATAGAAAAGTCAATCAATAGGAAAAGATAATCCAGGACGGTGTTGTGAACAGAAAGAGG
GGGAAAAAACTTTAGAAAATGATGGGGATGCTCTTACTGGGGTACGAGTCCTCAGGTATTGAACTGGCTT
TCAGTAAAAGCTAGATTAGTGGGTTCCTGCCATTTACAAGCTGTTTTATGACAACTTACTTGTTGGGTGG
CCTACAGTAACTCACCTAACTGCACTGAGTCTGTTTCCTCATCTGTAAATTGGGGATTTTTTTTTAAATA
CCTGGCATGCCTAACTCATAAAGTTGTTCTGAAACTGAAATAAAACATACGTGAACAGGCATTGTAAACT
GTAAGTTACGGAAAAAGCTGGCTGTTGTTGTGTCTTTAAAGTTTCACCTGGGTAGTCAAAGATGGATCAT
GGGTCTCAGTGGAGAGCTGAGCCAGGCAGGAGCTGACTAAGGGTGAGAGGTGGGAGTTAGCAGCCTCTGA
ACATCTGTGTACCATGGGACCCCCTTTCCTCCTGCATGGTACCCCAGACAAGGAGCCTAGTAAGAGATAC
TAATGGCTTGTTGTCCAGAGATGTTCAAACTGCAGAGAAAGATAAGACAACAAGCATTGGCCTCCAATCA
TGATGACAGATAGGAGGAGGTGGGAGCTCCTTAGCAGTGCTGGTTGGCCTTCCATGTTCTACTGTGGGCC
ATCTCTGCCATGTACTGTAGGCTACTAGCTTCTATATTAAAGAATGCAAGAGGGGCCAGGAGCGGAGGCT
CATGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTTGAGGTCAGGAGTTTGTGACCA
GCCTGGCCAACATGGTGAAACTCTGCCTTTACTAAAAATATAAAAATTAGCTGGGTGTGGTGGTGTGCAC
CTGTAATCCCAGCTACTCGGGAGACTGAGGCACAAGAATTGCTTGAACCTGGGAGGCGGAAGTTGCAGTG
AGCCCAGATTGCGCCACTGCACTCCACCCTGGGCAACAGAGAAAGACTCTGCCTCAAAAAAAAAAAAAAA
AAGCAAGAGGAAGTGAAATAATCAAGGCCGCCATTTAATAGTGAGCAGCCACTCCATGTGGTACTGTGCA
AGCACATTATAAATATTAGCCTCACAAGAAATGTATTAGCATTTGTATTTTGTACACTGGTTAAGTATCT
TGCCCAAGACCTCAAAACTGGTTAAGGGCAGCAGAATTTAGCCCCAGCACCACCTTTTCAAAGCCTGGGC
TTCTCACACTTCTCCATGCTGTTCCCATTTTAACACAGGTATCTCGCCATTCCAGCCACTCAAACTTTGG
CATTTAAGAAAATTATCCTAAAGCTAAACTAAACTTCAAGGATGACCATTCTCCTGACCCCTTCCCATCA
AAATTTTATCTTTAGTCAGTTTGTTTTCGTTTTGTTTTGTTTTTCAGAACTACCTCTGGCACATCCTCCA
AATGAAAGGACTCACTTGGTAATTCTGGGAGCCATCTTATTATGCCTTGGTGTAGCACTGACATTCATCT
TCCGTTTAAGAAAAGGTAGTATTTCCTTAATTGCAGTGGTCTCCACTGGGGGTGAGGAAGGGGTGAGAAT
TGGATCATGGCTGCAAGGAAACCCGACTTAACCTCTGCAAGGTGGTGCAAAGGCATTCCACTGTTCAACA
GCAATTATATTGAAGCTGAGTGGGATCACTGGGTGAAGATGAAGCGTAAGGGGTGAGGGGCAGGAGAATG
GGTATGGATGGAGGTAGAAGATGCAGTGTCATACAGTTTTTTTCTATCATGAAAATAACCACAGACTTAC
AGAAGAGAAAGAGCTAAAATGCCCGTCATTTTCAGTTGCATTTTAGTCTTGCATTAGTTGCAACCAGCTG
GTTTCTGGGTACCCTAAGTAATAAAAATAGTTCCTCTGTAGAACTGTAGTATGTTTACCATAGAGTATTT
TGCAAAATTTTTGGTAGAGGATGTTACATAATTTGCATGTGTTCATTTCTCCATTTACCTGTGGGAACAA
TTAAAATCCAGGAAAATGAGTATATTCAAATAATTTCCTCCCATTTAAGATGAGTCAGAGTAAATAATTC
CTCCAATACTTAGAGAAGTATACCAAGAGATCCAGTGATGGTATAGAGTTGTCTGATGTTAAATAGGGAA
GTAGAATATGGAAGGGGATTCCAATAGTCGTTGAAAAATTCCCCATAACCCCTTACATGGGGGAAAGTAG
TGTTAACTGAGAGAGTAGAGATAAGCTGTTTCCAAAAATTATATTCTTAACAGGACTGAGATAGCCAGAA
TATAAGGATCAAGTTTCAATGACAGTAAGATCCTGAGATGGAGTTGATTTGCACAAAGAAATAATTGTTG
CCAGCATGCATTTTGAATATTTCTCTGGAAAAAAAGATTAGTTGGCAGTAGAAATGGATAGAAATCAATA
GATATTAAAATACCTCAGAATTTGGTTCATCTCTGGGAAAAGATGAAAAATAAAAGTGTATACTCCTCAA
GAACATCTAGGATCAAAAGCATGTGCCCTACACTATTGAATTAATTAACCTCATAAGTTGGGACCTGTGG
AATAAGGATGTCCACCAGACTTCCTAGGGATTACAAATGTTTCACAGAACTTGAAATTTAAACTTGGGTC
ACTGTATGGGATGTAGAGCTGTGCTATATGGAAATAAAAATGATTTCTTTTTCTCAAGGGAGAATGATGG
ATGTGAAAAAATGTGGCATCCAAGATACAAACTCAAAGAAGCAAAGTGGTAAGAATATCAGAAGGAATTG
GGAAGTAAAAGTCAAAGGAAACAAAAAGCTAAAGCAATAACAAAGAGAAATCCATCAGTCATAATCTCCT
CTCCTTTTAAAGAATGCTGGTTCCCCTTTGCCTCACAGCTAACACAAGAACTCCTCCACCGTCTGAGGAG
GTTTAGGAGCAGGGAAGGGGAAGGAGTCAGCTTCATTTGCTAATCTTCTGTTGCCCTGCACCCTAGCAGC
TCCTTGCAGCAGGGGACAAGGATGACTTAGGTGGATGGATAATTAATTGATTCTAAAATATTGTGTGTCA
GTATTGTAATACTATGTTAATTGCACCATGCACGGTATCTCATTTAATCCCCCACCCCTTGCCATTACCA
AAGAGAGAGAGAGAGAGAGAGAGAGAAATACTAGAATTTATCCTCATTTTACAGTAGAGAAAACAGAGGG
TCAAGAAGATAATGTAAAGTGCCCAAGAACACACAGCTGATCACAAAAATCAAGCTTGGGGGCCATTAGC
CTAACCACAGACCCTTACTCTTAACCCATCTGCTTCAATCCATTTTGCTACAAATGTTTACATTTATAAG
CAGGGCAGAAAAACCTCATCCAGGTTATTGAACTAAGAAGAAAGTTATATTAAGGTTTCTAATTTTTTTA
ATGTAGTTAGAAACCAAACTTAACAATGAGCCCAAGTTTAAAGCAGTCTAATTAACCTGGACAAGCTCAG
GCAAGTTTCATTCTGTGGCCCATAGCATCATCTGTGTTGTAAAGCTAAGTAGCAAATGTTGTTTGGGTCA
TGCTGGGGGACAAGCCATCCCAATTTGCTCAGGACTGAGGGGTTTTCCAGGATATCATGTAAGGATAATT
GGGTACAAATATAACCTGCTGCTTTCTCTCATTTCAAATTTATCATTTATCATATCAGCAACTATGAGTT
ATGTTTTTTATTAGATTTCTTGTTACTTTTTCCCCAGACCACTTCCCATGAAATTAATATACTATTATCA
CTCTCCAGATACACATTTGGAGGAGACGTAATCCAGCATTGGAACTTCTGATCTTCAAGCAGGGATTCTC
AACCTGTGGTTTAGGGGTTCATCGGGGCTGAGCGTGACAAGAGGAAGGAATGGGCCCGTGGGATGCAGGC
AATGTGGGACTTAAAAGGCCCAAGCACTGAAAATGGAACCTGGCGAAAGCAGAGGAGGAGAATGAAGAAA
GATGGAGTCAAACAGGGAGCCTGGAGGGAGACCTTGATACTTTCAAATGCCTGAGGGGCTCATCGACGCC
TGTGACAGGGAGAAAGGATACTTCTGAACAAGGAGCCTCCAAGCAAATCATCCATTGCTCATCCTAGGAA
GACGGGTTGAGAATCCCTAATTTGAGGGTCAGTTCCTGCAGAAGTGCCCTTTGCCTCCACTCAATGCCTC
AATTTGTTTTCTGCATGACTGAGAGTCTCAGTGTTGGAACGGGACAGTATTTATGTATGAGTTTTTCCTA
TTTATTTTGAGTCTGTGAGGTCTTCTTGTCATGTGAGTGTGGTTGTGAATGATTTCTTTTGAAGATATAT
TGTAGTAGATGTTACAATTTTGTCGCCAAACTAAACTTGCTGCTTAATGATTTGCTCACATCTAGTAAAA
CATGGAGTATTTGTAAGGTGCTTGGTCTCCTCTATAACTACAAGTATACATTGGAAGCATAAAGATCAAA
CCGTTGGTTGCATAGGATGTCACCTTTATTTAACCCATTAATACTCTGGTTGACCTAATCTTATTCTCAG
ACCTCAAGTGTCTGTGCAGTATCTGTTCCATTTAAATATCAGCTTTACAATTATGTGGTAGCCTACACAC
ATAATCTCATTTCATCGCTGTAACCACCCTGTTGTGATAACCACTATTATTTTACCCATCGTACAGCTGA
GGAAGCAAACAGATTAAGTAACTTGCCCAAACCAGTAAATAGCAGACCTCAGACTGCCACCCACTGTCCT
TTTATAATACAATTTACAGCTATATTTTACTTTAAGCAATTCTTTTATTCAAAAACCATTTATTAAGTGC
CCTTGCAATATCAATCGCTGTGCCAGGCATTGAATCTACAGATGTGAGCAAGACAAAGTACCTGTCCTCA
AGGAGCTCATAGTATAATGAGGAGATTAACAAGAAAATGTATTATTACAATTTAGTCCAGTGTCATAGCA
TAAGGATGATGCGAGGGGAAAACCCGAGCAGTGTTGCCAAGAGGAGGAAATAGGCCAATGTGGTCTGGGA
CGGTTGGATATACTTAAACATCTTAATAATCAGAGTAATTTTCATTTACAAAGAGAGGTCGGTACTTAAA
ATAACCCTGAAAAATAACACTGGAATTCCTTTTCTAGCATTATATTTATTCCTGATTTGCCTTTGCCATA
TAATCTAATGCTTGTTTATATAGTGTCTGGTATTGTTTAACAGTTCTGTCTTTTCTATTTAAATGCCACT
AAATTTTAAATTCATACCTTTCCATGATTCAAAATTCAAAAGATCCCATGGGAGATGGTTGGAAAATCTC
CACTTCATCCTCCAAGCCATTCAAGTTTCCTTTCCAGAAGCAACTGCTACTGCCTTTCATTCATATGTTC
TTCTAAAGATAGTCTACATTTGGAAATGTATGTTAAAAGCACGTATTTTTAAAATTTTTTTCCTAAATAG
TAACACATTGTATGTCTGCTGTGTACTTTGCTATTTTTATTTATTTTAGTGTTTCTTATATAGCAGATGG
AATGAATTTGAAGTTCCCAGGGCTGAGGATCCATGCCTTCTTTGTTTCTAAGTTATCTTTCCCATAGCTT
TTCATTATCTTTCATATGATCCAGTATATGTTAAATATGTCCTACATATACATTTAGACAACCACCATTT
GTTAAGTATTTGCTCTAGGACAGAGTTTGGATTTGTTTATGTTTGCTCAAAAGGAGACCCATGGGCTCTC
CAGGGTGCACTGAGTCAATCTAGTCCTAAAAAGCAATCTTATTATTAACTCTGTATGACAGAATCATGTC
TGGAACTTTTGTTTTCTGCTTTCTGTCAAGTATAAACTTCACTTTGATGCTGTACTTGCAAAATCACATT
TTCTTTCTGGAAATTCCGGCAGTGTACCTTGACTGCTAGCTACCCTGTGCCAGAAAAGCCTCATTCGTTG
TGCTTGAACCCTTGAATGCCACCAGCTGTCATCACTACACAGCCCTCCTAAGAGGCTTCCTGGAGGTTTC
GAGATTCAGATGCCCTGGGAGATCCCAGAGTTTCCTTTCCCTCTTGGCCATATTCTGGTGTCAATGACAA
GGAGTACCTTGGCTTTGCCACATGTCAAGGCTGAAGAAACAGTGTCTCCAACAGAGCTCCTTGTGTTATC
TGTTTGTACATGTGCATTTGTACAGTAATTGGTGTGACAGTGTTCTTTGTGTGAATTACAGGCAAGAATT
GTGGCTGAGCAAGGCACATAGTCTACTCAGTCTATTCCTAAGTCCTAACTCCTCCTTGTGGTGTTGGATT
TGTAAGGCACTTTATCCCTTTTGTCTCATGTTTCATCGTAAATGGCATAGGCAGAGATGATACCTAATTC
TGCATTTGATTGTCACTTTTTGTACCTGCATTAATTTAATAAAATATTCTTATTTATTTTGTTACTTGGT
ACACCAGCATGTCCATTTTCTTGTTTATTTTGTGTTTAATAAAATGTTCAGTTTAACATCCCA
|
| Protein Name |
PD1L1_HUMAN |
| Length |
290 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
10-MAY-2005 |
| Definition |
RecName: Full=Programmed cell death 1 ligand 1; Short=PD-L1; Short=PDCD1 ligand 1; Short=Programmed death ligand 1; Short=hPD-L1; AltName: Full=B7 homolog 1; Short=B7-H1; AltName: CD_antigen=CD274; Flags: Precursor |
| Primary Accession |
Q9NZQ7 |
| Accession Version |
Q9NZQ7.1 |
| Other SeqIDs |
sp|Q9NZQ7.1|PD1L1_HUMAN,gi|83287884 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Apr 22, 2014 this sequence version replaced gi:121948354, gi:121948736.; [FUNCTION] Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.; [FUNCTION] The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.; [SUBUNIT] Interacts with PDCD1 (PubMed:11015443, PubMed:18287011, PubMed:26602187). Interacts (via transmembrane domain) with CMTM4 and CMTM6 (PubMed:28813417, PubMed:28813410). {ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:18287011, ECO:0000269|PubMed:26602187, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.; [INTERACTION] Q9NZQ7; P33681: CD80; NbExp=11; IntAct=EBI-4314282, EBI-1031024; Q9NZQ7; Q8IZR5: CMTM4; NbExp=3; IntAct=EBI-4314282, EBI-3925367; Q9NZQ7; Q9NX76: CMTM6; NbExp=14; IntAct=EBI-4314282, EBI-1054315; Q9NZQ7; Q15116: PDCD1; NbExp=17; IntAct=EBI-4314282, EBI-4314328; Q9NZQ7-1; Q15116: PDCD1; NbExp=2; IntAct=EBI-15686469, EBI-4314328.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation. {ECO:0000269|PubMed:28813417}.; [SUBCELLULAR LOCATION] [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}.; [SUBCELLULAR LOCATION] [Isoform 2]: Endomembrane system {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=PD-L1I; IsoId=Q9NZQ7-1; Sequence=Displayed; Name=2; Synonyms=PD-L1II; IsoId=Q9NZQ7-2; Sequence=VSP_013735; Name=3; IsoId=Q9NZQ7-3; Sequence=VSP_013736, VSP_013737.; [TISSUE SPECIFICITY] Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.; [INDUCTION] Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410}.; [PTM] Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation. {ECO:0000269|PubMed:28813410}.; [DISEASE] Note=Truncation of the 3'-untranslated (3'-UTR) region of CD274 transcripts leads to elevated expression of CD274 in multiple cancers including T-cell leukemia, diffuse large B-cell lymphoma and stomach adenocarcinoma (PubMed:27281199). Disruption of 3'-UTR region is caused by structural variants that stabilize CD274 transcripts, leading to overexpression (PubMed:27281199). Increased expression in tumors promotes immune evasion and tumor cell growth by allowing malignant cells to escape destruction by the immune system (PubMed:27281199). {ECO:0000269|PubMed:27281199}.; [MISCELLANEOUS] [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.; [SIMILARITY] Belongs to the immunoglobulin superfamily. BTN/MOG family. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=BAA91966.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}. |
| Source Db |
UniProtKB: locus PD1L1_HUMAN, accession Q9NZQ7;; class: standard.; extra accessions:B2RBA2,B4DU27,Q14CJ2,Q2V8D5,Q66RK1,Q6WEX4,Q9NUZ5; created: May 10, 2005.; sequence updated: Oct 1, 2000.; annotation updated: Oct 12, 2022.; xrefs: AF177937.1, AAF25807.1, AF233516.1, AAG18508.1, AY254342.1, AAP13470.1, AY291313.1, AAP42144.1, AY714881.1, AAU09634.1, DQ286582.1, ABB90152.1, AK001894.1, BAA91966.1, AK300470.1, BAG62189.1, AK314567.1, BAG37149.1, AL162253.17, CH471071.2, EAW58763.1, BC069381.1, AAH69381.1, BC074984.2, AAH74984.1, BC113734.1, AAI13735.1, BC113736.1, AAI13737.1, NP_001254635.1, NP_054862.1, 3BIK_A, 3BIS_A, 3BIS_B, 3FN3_A, 3FN3_B, 3SBW_C, 4Z18_A, 4Z18_B, 4ZQK_A, 5C3T_A, 5GGT_A, 5GRJ_A, 5IUS_C, 5IUS_D, 5J89_A, 5J89_B, 5J89_C, 5J89_D, 5J8O_A, 5J8O_B, 5JDR_A, 5JDR_B, 5JDS_A, 5N2D_A, 5N2D_B, 5N2D_C, 5N2D_D, 5N2F_A, 5N2F_B, 5NIU_A, 5NIU_B, 5NIU_C, 5NIU_D, 5O45_A, 5O4Y_B, 5O4Y_C, 5O4Y_E, 5X8L_A, 5X8L_B, 5X8L_C, 5X8L_D, 5X8L_E, 5X8M_A, 5XJ4_A, 5XXY_A, 6L8R_A, 6NM7_A, 6NM7_B, 6NM8_A, 6NM8_B, 6NNV_A, 6NNV_B, 6NNV_C, 6NNV_D, 6NOJ_A, 6NOJ_B, 6NOS_A, 6NOS_B, 6NP9_A, 6PV9_A, 6R3K_A, 6R3K_B, 6R3K_C, 6R3K_D, 6RPG_A, 6RPG_B, 6VQN_A, 6VQN_B, 6VQN_C, 6YCR_A, 7BEA_A, 7BEA_B, 7C88_C, 7C88_M, 7CZD_B, 7CZD_D, 7DY7_A, 7DY7_B, 7NLD_A, 7NLD_B, 7NLD_C, 7NLD_D, 7NLD_E, 7NLD_F, 7OUN_A, 7TPS_B, 7TPS_D; xrefs (non-sequence databases): CCDS:CCDS59118.1, CCDS:CCDS6464.1, PDBsum:3BIK, PDBsum:3BIS, PDBsum:3FN3, PDBsum:3SBW, PDBsum:4Z18, PDBsum:4ZQK, PDBsum:5C3T, PDBsum:5GGT, PDBsum:5GRJ, PDBsum:5IUS, PDBsum:5J89, PDBsum:5J8O, PDBsum:5JDR, PDBsum:5JDS, PDBsum:5N2D, PDBsum:5N2F, PDBsum:5NIU, PDBsum:5O45, PDBsum:5O4Y, PDBsum:5X8L, PDBsum:5X8M, PDBsum:5XJ4, PDBsum:5XXY, PDBsum:6L8R, PDBsum:6NM7, PDBsum:6NM8, PDBsum:6NNV, PDBsum:6NOJ, PDBsum:6NOS, PDBsum:6NP9, PDBsum:6PV9, PDBsum:6R3K, PDBsum:6RPG, PDBsum:6VQN, PDBsum:6YCR, PDBsum:7BEA, PDBsum:7C88, PDBsum:7CZD, PDBsum:7DY7, PDBsum:7NLD, PDBsum:7OUN, PDBsum:7TPS, AlphaFoldDB:Q9NZQ7, SMR:Q9NZQ7, BioGRID:118891, DIP:DIP-29731N, IntAct:Q9NZQ7, STRING:9606.ENSP00000370989, BindingDB:Q9NZQ7, ChEMBL:CHEMBL3580522, DrugBank:DB15773, DrugBank:DB11595, DrugBank:DB15771, DrugBank:DB11945, DrugBank:DB15772, DrugBank:DB15770, DrugBank:DB11714, DrugBank:DB15769, DrugCentral:Q9NZQ7, TCDB:8.A.23.5.1, GlyGen:Q9NZQ7, iPTMnet:Q9NZQ7, PhosphoSitePlus:Q9NZQ7, SwissPalm:Q9NZQ7, BioMuta:CD274, DMDM:83287884, EPD:Q9NZQ7, jPOST:Q9NZQ7, MassIVE:Q9NZQ7, MaxQB:Q9NZQ7, PaxDb:Q9NZQ7, PeptideAtlas:Q9NZQ7, PRIDE:Q9NZQ7, ProteomicsDB:83483, ProteomicsDB:83484, ProteomicsDB:83485, ABCD:Q9NZQ7, Antibodypedia:24139, CPTC:Q9NZQ7, DNASU:29126, Ensembl:ENST00000381573.8, Ensembl:ENSP00000370985.4, Ensembl:ENSG00000120217.14, Ensembl:ENST00000381577.4, Ensembl:ENSP00000370989.3, GeneID:29126, KEGG:hsa:29126, MANE-Select:ENST00000381577.4, UCSC:uc003zje.4, CTD:29126, DisGeNET:29126, GeneCards:CD274, HGNC:17635, HPA:ENSG00000120217, MIM:605402, neXtProt:NX_Q9NZQ7, OpenTargets:ENSG00000120217, PharmGKB:PA134915280, VEuPathDB:HostDB:ENSG00000120217, eggNOG:ENOG502S1Y9, GeneTree:ENSGT00940000161430, HOGENOM:CLU_1744717_0_0_1, InParanoid:Q9NZQ7, OMA:AGVYCCM, OrthoDB:892262at2759, PhylomeDB:Q9NZQ7, TreeFam:TF331083, PathwayCommons:Q9NZQ7, Reactome:R-HSA-389948, Reactome:R-HSA-9701898, SignaLink:Q9NZQ7, SIGNOR:Q9NZQ7, BioGRID-ORCS:29126, ChiTaRS:CD274, EvolutionaryTrace:Q9NZQ7, GeneWiki:PD-L1, GenomeRNAi:29126, Pharos:Q9NZQ7, PRO:PR:Q9NZQ7, Proteomes:UP000005640, RNAct:Q9NZQ7, Bgee:ENSG00000120217, Genevisible:Q9NZQ7, GO:0015629, GO:0031901, GO:0009897, GO:0070062, GO:0016021, GO:0005654, GO:0005886, GO:0055038, GO:0002250, GO:0007166, GO:0071222, GO:0006955, GO:0046007, GO:2000562, GO:2001186, GO:0032689, GO:0032693, GO:0042130, GO:1903556, GO:1905404, GO:0030335, GO:0032733, GO:0042102, GO:0002845, GO:0034097, GO:0007165, GO:0031295, GO:1901998, Gene3D:2.60.40.10, InterPro:IPR013162, InterPro:IPR007110, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003599, InterPro:IPR013106, Pfam:PF08205, Pfam:PF07686, SMART:SM00409, SUPFAM:SSF48726, PROSITE:PS50835 |
| Sequence |
mrifavfifmtywhllnaftvtvpkdlyvveygsnmtieckfpvekqldlaalivywemedkniiqfvhgeedlkvqhssyrqrarllkdqlslgnaalqitdvklqdagvyrcmisyggadykritvkvnapynkinqrilvvdpvtseheltcqaegypkaeviwtssdhqvlsgkttttnskreeklfnvtstlrintttneifyctfrrldpeenhtaelvipelplahppnerthlvilgaillclgvaltfifrlrkgrmmdvkkcgiqdtnskkqsdthleet |
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