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| Record Information |
| Record ID |
32 |
| Pubmed ID |
32500232 |
| SNP |
|
| Gene ID |
54742 |
| Protein ID |
Q17RY6 |
| Vaccine Adverse Events |
injection site reactions, eosinophilic pneumonia, influenza-like symptoms and anaphylactic reactions. |
| Vaccine |
esophageal cancer peptide vaccine |
| Gene Name |
LY6K |
| Official Symbol |
lymphocyte antigen 6 family member K [Homo sapiens (human)] |
| Aliases |
CT97, HSJ001348, URLC10, ly-6K |
| Other Designations |
lymphocyte antigen 6K; cancer/testis antigen 97; lymphocyte antigen 6 complex, locus K; up-regulated in lung cancer 10 |
| Chromosome |
8 |
| Location |
8q24.3 |
| Annotation |
Chromosome 8 NC_000008.11 (142700111..142705127) |
| MIM |
615093 |
| DNA Sequence |
>NC_000008.11:142700111-142705127 Homo sapiens chromosome 8, GRCh38.p14 Primary Assembly
GAGTTATCAGAGGTGAGCCCGTGCTCTTCAGCGGAGAAGATCCCCTACCTGGCCGCCGGCCACTTTCTGT
GGGCCGTGGGGTCCTCAAGGAGACGGCCCTTGGGCTCAGGGGCTGCGTTTCCACACGCGCCTTTCCCAGG
GCTCCCGCGCCCGTTCCTGCCTGGCCGCCGGCCGCTCCAACAGCAGCACAAGGCGGGACTCAGAACCGGC
GTTCAGGGCCGCCAGCGGCCGCGAGGCCCTGAGATGAGGCTCCAAAGACCCCGACAGGCCCCGGCGGGTG
GGAGGCGCGCGCCCCGGGGCGGGCGGGGCTCCCCCTACCGGCCAGACCCGGGGAGAGGCGCGCGGAGGCT
GCGAAGGTTCCAGAAGGGCGGGGAGGGGGCGCCGCGCGCTGACCCTCCCTGGGCACCGCTGGGGACGATG
GCGCTGCTCGCCTTGCTGCTGGTCGTGGCCCTACCGCGGGTGTGGACAGACGCCAACCTGACTGCGAGAC
AACGAGATCCAGAGGACTCCCAGCGAACGGGTGAGCCTGGCTCGCCCTCCACAGCCACGGGCCGAGAGGA
CAGGGCCGGGCGGCGTCTGCCTGGCACCGCGTGGCCACCGCCCCGACCAGGCCGTGAGAACGGAGCGTTC
AGGCGGCCCGTGGCGCCTGGAAGCCTCTGGGGAGCCTCGCCTCGTGCGGCTTCCACCAGGGCGGCGGGGC
AGCCTGAGCCCGGCCCTTCCCCAGCCCTTGCCCCGCTCCGGCCGCGCTTCCCCGGGAGCCCTCAGGCTGC
AGGCTCCCGCCGGCCTGGCCTCCGGGGGCTTCACGGGCTGAGAACCGTTCAAGCTGCGGGAGGAGGGCCG
GCTCCTCCTGCAGAGCTAGGCCAGGCCCAACCCAGACCCAAGGGAGAACTCCTTTGAGGGAGTCGGGGGG
CAGGACCTGGGAGGTGGGTGGACCTGGGAGGTGGGCGGGAGGGCACGTGGGAGCAGACCCAAGCCCCAGG
GTCACTTCCACAGCCGTCGGCCGGGAGATGCCAGGGCCCGTGGGTGCCGCGTGGCCGACCTGGGGTCAGG
GTGCTGCGGCCGAGTGGGGGTGCGCTGTGCGCTCATGTTGTGTGCTTGGATGTGGGAGGACGGGGGAGCC
CCCAGGAGAGAAGAAAAATCACTCAGAATGTAAAGAAGTCCGGGGGCTGGGCAATTTATAAAGAAGAGAG
GTGGAATTGGCTCACAGTTCCACAGGCTGTCCAGGAAGCGTGGTGCTGGCTTCTGGGGAGGCCTCAGGGC
ACTTACAATCATGGGGGAAGGCGAAGGGGAAGCGGGCAGCTCTTACGTGGCCGGAGACCCCTCCTGCTTT
CTCCCCATGCGGCTCACTCGAGTCATGTGGCCCCAGCCACTGCTCAGGGGGAGAAGGATGGGGACCCGCC
GAGTTTGTGCTGGTCGGATGCCGGCTGTGTTCATCAGATAGGCACGGAGAACTGGAACATTCTGCTTTCT
TTTTTATTCCTCCTTTCAGACGAGGGTGACAATAGAGTGTGGTGTCATGTTTGTGAGAGAGAAAACACTT
TCGAGTGCCAGAACCCAAGGAGGTGCAAATGGACAGAGCCATACTGCGTTATAGCGGCCGTGAGTGAGTA
TCTTCGCTCTTGTTGGGGACCCAAAGGCAGGTGAACAGAGGGCTTTCAGGAATCAGGGCTGTCTAGTTTT
CCTCAATGGGGAATAACTAATAGAAAGTAGCCTTTTTTTTTTTTTATTTTCTGAGACGGAGTCAGGCTGG
AGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCGCCTTCCGGGTTCAAGCGATTCTCCTGCCTCAGCC
TCCAGAGTAGCTGGTATTATGGATGCGCGCCACCACACTGGCTAATTTTTTATTTTTAGTAGAGGTGGGG
TTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGACCCACCCGCCCTCGGCCCCCCAA
AGTGCTGGGATTACAAGCGTAAGCCACCGCGCCCTGCCTTTTTTTCCCTTTAAAATGTGAAGAGCAAAGT
CCTCAGAGGCCAGAGAGAGGTGTAGGAACTGTGCTAGTGTAAGGCAGTGCCTGCTACAGTGGGTCCAGAT
GAAATACTGGGAGGTAGGAAGAAAATCTGGATTTCATATCATCCATTTTTAAATGAAAAATTAAGCTTTA
ATAGTGTTAAATGCGCCACAGAGAACAGTGTCTATGTCACTCTTACAAGAGATGCACAAAACCAAGGTGT
ACAGCCTTCAAGTGTGTTCTCAAAGGAGGGTGCATGCCTTAAAAATTGTGGAGACCACTGCTCTGTCATC
TGTGATTCCCCTGAAAACCTCTGGGTACATGAAGCCCTCCCCAAGGGGAATCTGGACACCCAGCACATTC
TGCCCACAGGGAGATCTTCAGGGCTCGTGAATTCTGATTCCGCCCAGCAGTCACTCTCCAGCCCTTCGGT
ATCCACGAAGTTGGTGGGGTGCTGAGGTGATGCTTCAGACTCAGTGTGGCCCACATCGACTTTATAACTT
AATATGGCAAAATGATTTGTACAGTGATGTATAAGATGAAGTGTGGTCATGAGACAAGACCCCCAGCTCA
GAGTCGAGCCAGGCCCACCAAGAGGCCAGCTCCACACCCTGGGTGATGGCCAGAATGGCTGGGAGTCATG
TGTCTGTCTGTGGTCACAAAGGCCTGAGCCAACCCTGTGTTTGAGAAGTTGAGACCTGTTTGTTCCCAAA
CAGCAACCCCTAGACCCGCATTCCCAGTGCATATGGACAGGCCATACCACGCAGAAGCCAGCCCTTCCCT
GAAGCAGCATTCAACACACAGGCCTGGCCCTCGTCCTCCCGACTCCCCCTTGGTGCCCCAGTTGACTGTG
CACCTTTGAGCAGGGCCGCCAGGGGTGAGGCTTTGACCCAGACAGAAGGGCCTCGGTGTCAGGCATTGGA
ATTGCGTGATTGCCTTCTCTCGGTCTTTATTTCCTATTAGAAATATTTCCACGTTTTTTCATGGTTGCGA
AGCAGTGCTCCGCTGGTTGTGCAGCGATGGAGAGACCCAAGCCAGAGGAGAAGCGGTTTCTCCTGGAAGA
GCCCATGCCCTTCTTTTACCTCAAGTGTTGTAAAATTCGCTACTGCAATTTAGAGGGGCCACCTATCAAC
TCATCAGTGTTCAAAGAATATGCTGGGAGCATGGGTGAGAGCTGTGGTGGGCTGTGGCTGGCCATCCTCC
TGCTGCTGGCCTCCATTGCAGCCGGCCTCAGCCTGTCTTGAGCCACGGGACTGCCACAGACTGAGCCTTC
CGGAGCATGGACTCGCTCCAGACCGTTGTCACCTGTTGCATTAAACTTGTTTTCTGTTGATTACCTCTTG
GTTTGACTTCCCAGGGTCTTGGGATGGGAGAGTGGGGATCAGGTGCAGTTGGCTCTTAACCCTCAAGGGT
TCTTTAACTCACATTCAGAGGAAGTCCAGATCTCCTGAGTAGTGATTTTGGTGACAAGTTTTTCTCTTTG
AAATCAAACCTTGTAACTCATTTATTGCTGATGGCCACTCTTTTCCTTGACTCCCCTCTGCCTCTGAGGG
CTTCAGTATTGATGGGGAGGGAGGCCTAAGTACCACTCATGGAGAGTATGTGCTGAGATGCTTCCGACCT
TTCAGGTGACGCAGGAACACTGGGGGAGTCTGAATGATTGGGGTGAAGACATCCCTGGAGTGAAGGACTC
CTCAGCATGGGGGGCAGTGGGGCACACGTTAGGGCTGCCCCCATTCCAGTGGTGGAGGCGCTGTGGATGG
CTGCTTTTCCTCAACCTTTCCTACCAGATTCCAGGAGGCAGAAGATAACTAATTGTGTTGAAGAAACTTA
GACTTCACCCACCAGCTGGCACAGGTGCACAGATTCATAAATTCCCACACGTGTGTGTTCAACATCTGAA
ACTTAGGCCAAGTAGAGAGCATCAGGGTAAATGGCGTTCATTTCTCTGTTAAGATGCAGCCATCCATGGG
GAGCTGAGAAATCAGACTCAAAGTTCCACCAAAAACAAATACAAGGGGACTTCAAAAGTTCACGAAAAAA
TTGAATTAAAAGATAAAAATTAAAAAATGTTTTATTTCTCAGCATGAGCTCCATCAAGGTCGAGACGCTT
CTGCAAGTAATGGTACCAGCCATTCAGTTCATCCCTAAAGAATTGGGCACCCTGGGAATTTAACCATGCC
ACTTCAGTCTTTGTGACGTTATTAACTGAAGAAAAGTGGGTGCCCTTTAAAGATTTTTTAAAATTATAAA
ACAGAAGTAACCAAATCAGGCCTGGAAGGTGTATGCCTAGTGATTTCCCATTGAAACTCTCACAAAACTG
GCCTTGTTTGATGAGAGGAATGAGCAGGAGCATTGTCATGGTGGAGAAGGGCTCTCTGGTGAAGCTTTCC
GGGGTGACGATTTCCTGGGTGTTTTCCTGCTAAATCGTTGGCTGACTTTCTCTATACACTCTCATAATAA
GATGTTACTGTTCTTTGGCCCTCCAGAAAGTCAATAAGCAAGATGCCTTGAGCATTCACAAAACGGTTGC
CACGACCTTTGCCCTTGACATGTCTGCTTTTACTCTGATGGGACCACGCCCACCTCTAGGTAGTCATTGC
TTTGCTTGTGCTTTGCCTTCAGGAGTGTACTGGTTAAGCCACATTTCATCTCCGGCTATAATTATATGAA
GAAATGCTTCAGGATCTTGATTCCACTTGTTTAAAATGGCCATAGAACGCTTTTCTCTTATCTGCAGCTG
AGCTGGGAGAAAGTTTTGGCACCCACCGAGTGGACAGTTTACTCAACTTTAATTTCAGTCAGAATTGTGT
AAGCTGAACACCTTGGGATACCTACAGCGTTGGCTATTGTTTCTGCTGCTATTAATCAGTCCTCTTAAAT
TAGGGCACAAACAAGATGAATTGTTTCCTCACAGACTGATGTGGCTGGCCTGCTGCTGTGGACTTCCTCT
CCAACATCATCTCTTCTCTTCTTCCAATGAGTTATCCACTTACTTAA
|
| Protein Name |
LY6K_HUMAN |
| Length |
165 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
20-MAY-2008 |
| Definition |
RecName: Full=Lymphocyte antigen 6K; Short=Ly-6K; Flags: Precursor |
| Primary Accession |
Q17RY6 |
| Accession Version |
Q17RY6.2 |
| Other SeqIDs |
sp|Q17RY6.2|LY6K_HUMAN,gi|189028864 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before May 23, 2008 this sequence version replaced gi:74705498, gi:74733318, gi:121940593.; [FUNCTION] Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth (PubMed:18089789). {ECO:0000250|UniProtKB:Q9CWP4, ECO:0000269|PubMed:18089789}.; [SUBUNIT] Interacts with TEX101. {ECO:0000250|UniProtKB:Q9CWP4}.; [SUBCELLULAR LOCATION] Secreted {ECO:0000269|PubMed:18089789}. Cytoplasm {ECO:0000269|PubMed:18089789}. Cell membrane {ECO:0000250|UniProtKB:Q9CWP4}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9CWP4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9CWP4}. Membrane raft {ECO:0000250|UniProtKB:Q9CWP4}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q17RY6-1; Sequence=Displayed; Name=2; IsoId=Q17RY6-2; Sequence=VSP_045602, VSP_045603.; [TISSUE SPECIFICITY] Specifically expressed in testis (at protein level). {ECO:0000269|PubMed:12516096, ECO:0000269|PubMed:18089789}.; [SEQUENCE CAUTION] Sequence=AAH01291.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI17143.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI17145.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA04692.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA04692.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=EAW82311.1; Type=Erroneous initiation; Evidence={ECO:0000305}. |
| Source Db |
UniProtKB: locus LY6K_HUMAN, accession Q17RY6;; class: standard.; extra accessions:G3V116,O15227,Q9BVD7; created: May 20, 2008.; sequence updated: May 20, 2008.; annotation updated: Oct 12, 2022.; xrefs: AJ001348.1, CAA04692.1, AC108002.3, CH471162.2, EAW82311.1, BC001291.1, AAH01291.2, BC117142.1, AAI17143.1, BC117144.1, AAI17145.1, AI740834.1, NP_001153826.1, NP_001153827.1, NP_059997.3; xrefs (non-sequence databases): CCDS:CCDS59114.1, CCDS:CCDS6385.2, AlphaFoldDB:Q17RY6, BioGRID:120124, STRING:9606.ENSP00000292430, GlyGen:Q17RY6, iPTMnet:Q17RY6, PhosphoSitePlus:Q17RY6, BioMuta:LY6K, DMDM:189028864, EPD:Q17RY6, jPOST:Q17RY6, MassIVE:Q17RY6, MaxQB:Q17RY6, PaxDb:Q17RY6, PeptideAtlas:Q17RY6, PRIDE:Q17RY6, ProteomicsDB:32227, ProteomicsDB:61174, Antibodypedia:3032, CPTC:Q17RY6, DNASU:54742, Ensembl:ENST00000292430.10, Ensembl:ENSP00000292430.6, Ensembl:ENSG00000160886.13, Ensembl:ENST00000519387.1, Ensembl:ENSP00000429695.1, GeneID:54742, KEGG:hsa:54742, MANE-Select:ENST00000292430.10, UCSC:uc011ljv.3, CTD:54742, DisGeNET:54742, GeneCards:LY6K, HGNC:24225, HPA:ENSG00000160886, MIM:615093, neXtProt:NX_Q17RY6, OpenTargets:ENSG00000160886, PharmGKB:PA134987940, VEuPathDB:HostDB:ENSG00000160886, eggNOG:ENOG502TDVS, GeneTree:ENSGT00940000159966, HOGENOM:CLU_105666_0_0_1, InParanoid:Q17RY6, OMA:YCNLQGP, OrthoDB:1586315at2759, PhylomeDB:Q17RY6, TreeFam:TF336908, PathwayCommons:Q17RY6, Reactome:R-HSA-163125, BioGRID-ORCS:54742, GenomeRNAi:54742, Pharos:Q17RY6, PRO:PR:Q17RY6, Proteomes:UP000005640, RNAct:Q17RY6, Bgee:ENSG00000160886, ExpressionAtlas:Q17RY6, Genevisible:Q17RY6, GO:0001669, GO:0031225, GO:0005576, GO:0045121, GO:0005886, GO:0007339, Gene3D:2.10.60.10, InterPro:IPR045860, SUPFAM:SSF57302 |
| Sequence |
mallalllvvalprvwtdanltarqrdpedsqrtdegdnrvwchvcerentfecqnprrckwtepycviaavkifprffmvakqcsagcaamerpkpeekrflleepmpffylkcckirycnlegppinssvfkeyagsmgescgglwlaillllasiaaglsls |
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