|
|
| Record Information |
| Record ID |
253 |
| Pubmed ID |
31991189 |
| SNP |
|
| Gene ID |
50489 |
| Protein ID |
Q9UJ71 |
| Vaccine Adverse Events |
|
| Vaccine |
seasonal trivalent influenza vaccine |
| Gene Name |
CD207 |
| Official Symbol |
CD207 molecule [Homo sapiens (human)] |
| Aliases |
CLEC4K |
| Other Designations |
C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; CD207 antigen, langerin; CD207 molecule, langerin; Langerhans cell specific c-type lectin |
| Chromosome |
2 |
| Location |
2p13.3 |
| Annotation |
Chromosome 2 NC_000002.12 (70824130..70835816, complement) |
| MIM |
604862 |
| DNA Sequence |
>NC_000002.12:70824130-70835816 Homo sapiens chromosome 2, GRCh38.p14 Primary Assembly
TTTATGTTTTTTAATCCAGGACATTTTATTTAATAGTAGGGACAGCTTCTTGACATGATGTGAGCACTTG
TATTCAGCAGTACAAAGTGTCCTGATTTTACACCCTACAAAATACAGCAACAACAATTCAACACATTTAC
AGGCCTGAATGCAAACCACCTGGCTTTTATTCCGTTCGTCTCCTAACTGTTCTCCCTGCCTCTCCTCTTA
CCCCCTCTCAAGTCCTGTCACCATGGTGCAAGCATAATGATCTTTTCAAAAAAAATTAGATGTACACACA
AATATTACTTAGCTCTCTCAGCTGGGAGAGGCAATGATGTTCAAATAGCAACAGCCACACAGCCCCCAGG
TTTTGATTTCTAACACCATTCTCCAAAAAAAGGAAACCAGGGCTCATTAGAGAAATGGCTGACTCTAGAA
CTGGGGCAGGAAATACTCAAGATGAGCCTGGAGCATCTTGTAGTACCAGAAAGTAAGGAGATGCTTAGTT
ACCAAAAAAAAAAAAAAAAAAAAAAAACTGAGGGAAGTATGTCAAAATGACACAGGAACCAATGAAGGAG
CTCCCAATGGCCAAAGCCAGAGCAATTTGAGCAAAAACAAAACAAAAAAACAAATAAAATAGTATTGGAT
TATAACCCAAAGTGTAAGAGAAATATCTGTGAGTCCATACTGACATAAATGAATGTCTGAGTAAGTAAAC
AAATAGATAAGTCTCTAGGGCAGAAAATGTCCAAATATTTTATGTAAATATCCCATTCTGAGAAAAGTAG
AGTGTAACTTCCTACTCTTTCAGTGTGAACTGCATATAGTGACTTCCTTCCAAAAAGTTCAGTACAGGAA
AAGGGAGAAAAGAGTAATTCTGGAGTCAATAAACTTGGCAAACACTACCCCAGCCTGGAGATCAAGGTCA
ACGCCAACAGTAATGAATTCTATTGATGGTATGTACCCTTCATAGGATGTGATGAGAATGGCCCTTTATC
TCCATGGTCTTCCTCCTGAAACTCAGTACCCCAATGTAATCATGAGAAAAACACCAGACAAATTCCATTT
AAGGGACAATCTACAAAGTACCTGACCAGTGGGCTCCTCAAAACTGTCAAAGTCTTCAAAAACAAGGAAA
GACTGAGAAAATGTCACAGCCAAGAGGATCCCAAGGAGACATGATGGCTAAATGTAACGTGGTATTCTGG
ATGGGATCCTAGGAGAGAAAAAGGATGTTAGGGGAAAACCAACGAAATCTGAATAAAGTATGGACTTCAG
TTAAATATTGGCTCATTAATTGTGACAAATGTACCATACTAATATAAGATGTTAACAATCGGGGAAATGG
GAAAGGGTGGGTATATAGAAACTCTCTGTATTATCTTCACAATTTTTCTGTAAAGCTGAAACTATTCTAT
AATATAAAGTTTTTAAAAAAAATTTTTGAGACAGGGTCTCACTCTATCACCCAGGCTGGAGTACAGTGGC
GTGATTACAGCTCACTGCAGCCTTGACCTCCCAGGTTCAAGCAATTCTCCCACCTCAGACTCTTGATTTG
CTGGGACTACAGGCACACGCCACCACACACGGCTAAGTTTTGTATTTTTTTTTTAGAGACAGGGTCTCCC
TATGTTGCCCAGGCTGGCCTCAAACTCTTGTGATCAAGTGATTCTCCTTGAGTTCTGTGCTCTGTGAACA
CAGGCATGAGCCACTGAGCCCAGCCTAAAAAGGTATTTAAAAGATATTAGGGATGGCTGGGTATGGCAAC
TCACACCTGTAATCTAAGCACTTTGGGAAGCTGAGGCAGGAGGATCACCTGAGCTCAGGAGTTTGAAGCC
AGCCTGGGCAACATAGCAAGACCTCATCTCTACTAAAATTAAAAAAAAATTAGCTGGGCATGGTGGTGCA
CACCTGAGGTTCCAGGTACTCAGGAGGCTAAGGCAGGAGGATTGGTTAAACCCAGGAGTTCAAGGTTGCA
GTGAGCTGTGATTGTGCCACTGTACTCCAACCTGAGTGGCAAAGGGAGGCCCTGTCTCAAAAAAATCAAA
ATTAAAAAAAGACATAAGTAGTAATTATGGAATCTCAGAAGACCAGAGTCAAGCTTTAGAGTCTATGCTG
GCAGGAGGAATGCTCCAATAACGGCAGCACTAAATCTAGTCTGAGCTCTGAAAAAACACCAGGACAAATC
AAAGGTCTCACATGGTTGAATCTGACCGGTGGTCCCTGGGTCACATGACTGCACTTTAAAAATAAATAAA
TAATTAAATTAAATTAAATTAAATTAAAACAGGGTCTTGCTCTGTAGCCCAGGCTAGAATGCAGTGGTGT
GATCACAGCTCACTGCAGCCTCAATCTCTTGAGCCCAAGCAATCCTCCCACCTCAGCCTCCCAAGAGCTA
GGATTACAAGTCCGCACTACCACACCCAGCTAATTTTTTTTGTATTTTTTGTGGAGACGGGGTCCCACTG
GGTTGACCAAGCAGATCTTCAACTCCTGGCCTCAAGTGATCCTCCTGCCTTGGCTCCCAAAGGGCCTCCC
AAAGCATCTAGCCTCATGCCTGCACTTTTCTGCAAGGAAGGCTGTAAGTGCTAGTTCTGCTTCTAACTTT
AAAAGGTGAACTCAAAATACAGGAAGATACCTAAACCAAGAAGCTGTTCAGGATAAAGGAAGAACCACAA
GAGTGTGACAAATGTTTTCCAGTGACATAATTCTATTGCATGTCTGTAGATCTTGTTATTCCTGGAAGCA
TTTAAGCTTTCAAATGTAACAAATCATTTGTCACGCTTCTTCAACACTAAGTAAAAAACAGATGTCACTC
ATCTGCCTAAAACACTTCAATGTTTCCTCCTTGTCCTTCACATAAAATCCAAAACCCCTCCTCTGGCTTT
GAAGGCCCTCCAACAGCTGCCTGTCCCCTGCTTCACCTCACACCACACTCCAGCTAGACTGGAGTTCTCT
TGGTGCCTCAGGCCTGTCACACTCCTTCTCTGCATTTTCTGTTTTCTCTCTCTTTCCTCGTCTGTGTCCC
CATCCCACTCTGCCTAAATTCTGCTCATCTCTCAAGGCTCAGCTTATGTGCCTCTTCCTCAGGAAGCCTT
ACGAAATCCTTTCGCTTTAGGCTCCCACAGAACAATAAAAGTTTCCTTTTTGAAAACACACTGAGTTTAT
CATAAATTGGGTAGCCTGTGTTTTCTCCCCCAAAAACAGAGATTCATTCTGAGACCTGAAAAAAAAAAGA
AAGTTGCCTTGGGACAGATAGGAGGGGAGGTTCTTGGAGGTCTGGGATGGGAACAGAGAGGCAGAGAGAA
AGGAGGGCCTGAAATCTGTGAGGGAGGCAACGCATTGCCCTGCTGGGGGCTACCTGGAGCCCTGGCCAGG
TGGGGTCACCAAGGGAGCCAATGGCAGCCCCCATGCCCAGGGCCCAGCCCCAACCAGGGCAACAATGCCA
GGAATAATGCCAATAATCCCAGAAGCCAGGGTGCTTTGTAAGAAAAAGGGGAAGTGCTAGGCAACTACAC
ACGTGTGTGCGCGCACACACACACACACCCCACCCAAATAATGGCTTATCTTCCAAAGCACTGGGAAAAT
TAAAGCAAAGAAAGCATAGCTCATACAATATGAGAAAAAGAGGAGAGAGAGAAAGAGAAAGCGAGAGAGA
ATGACAAAGAGAAAATGAAGTGATTCAATAGATAGATAGATCAATAAAGCATAAAAACAGAAAAATAAAA
TATAGTACATGTTCACGAGCATTAGGACTAGTTGGTCAGTGGGGGTGATTCAAGTATTTTTTTCTCTTCT
TTTATATTCAAACACAAAAGGATAAATTTTTCAAGAGTATTTTATTGCAACATTGAAAGAGGGCATGTCA
AGCATTGTTAGCCTGCCAAATCAGAAAAAAAAAGAAAGAAAACAACTAATGTAATACAATAAATACCCAA
GTTGACTGAGAAAAAGTTCTCACCTGTCCCTGGCTCCCAACTTTTCACCTGACAATGGAAAAATCCCCAG
AATTTCACAAGAAATACTGTGGGGTCCATGATACGAGGAGCTGCCCAGGTATTGATAACACCCCAAGACC
TGCTAGAGACAGGACTAGAGCACTATCAATGGTGGGACTTCCTGGGCGAGGCCACACTGCCAGCAGAAGG
GCAGGTGCCCATGTAGCGACCTCCCTGGAGAAGCAAGGCATGCATACAGTGGGGGAGGGAGCCAAAGTCA
CAAGACAAAGCAAAGCGACAGGTGTCCCAGCTTCCTCAAGGGAGGAAGCCAAGGCAATGCTGCACTTGTT
GGGTTCAGGCTGGGGCACAGACTCCAGATAAAAACACATCCTCACTGACTCAGGCTCTTTCAGTTTCAAG
AAAAAGCAATGGTTGGGGTCAGGAGCACAGCCTCGTAAGGTCCCCATGCACAGAAACCAGGAGGATCAGA
AGGGCTGGGAGGATCTGAGGCAGCCCTGGGAACGGGAGCAGCCGGAGCCCTTCAGGCTGCCCTCCGGGAC
CTCCATTGCGACTCCTCTGAGCCGTTCTCTTTTCTCTGCCAACTATAATCCTCTGCAGTCACTTCTTTTT
TTTTGAAACAAAGTCTTGCCCTGTTGCCCAGGCTGGAGTGCAGTGGTGGGATCTCAGCTCACTGCAACCT
CTGCCTCCCAGATTCAAGCAATTCTCCTGCCTCAGTCTCCCAAGTAGTTGGAATTACAGGTGCCCACCAC
CATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGTCTCGAACT
CCTGACCTCAGGTGACCCACCCACTTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACCATGCC
AGGCCTGTATTCATGTCTTTCCCCTGCCTCATAGCTTCTGCTCATTGCTAGTTTCTTCCAATGCCACGTG
ACGGCCCCTCCAGCCTTTCTCTTAACTCAGTGCCTTCCAGCTCAACTTCCTTTTGTTAACAGCCTCATCC
TCTTGCTATTTCCTGGTTCAAATTCTTTCCCAGAGAAATGGTCTGATTTTCCCAGCTCATCTCTTTGCCA
AAACCAACCAGAGATCCCCGACCAGCCTTGTTCTTGTCACCTCCCATTTCCTCCATTGGTGAGGGAGGGA
TCCCCTGCTCTAAATAGGACAAGATGGCCAAAACAAGACATTTGACACTGTGCAGGTGAGACTGGCAGCA
GTTTACTAGTCACAAATACAGTCTACTGGGGAAAGATATCATAAGCCACACAGGGCCACATGGGGTCACC
CTCAGGAGCAGAGTGAACCAGCCAGGGCTGTGGGAGGCAGGCCTTGTAGTAATAAAAGGATGAGATGCCC
CGGATTCCTGTAGGAGGATGTGATTGGCTTGTTTGAATAGTTTCTCAGGCTGGCAGAGAAGTGAAACCCA
TTAAGTAGAAAACTGGGTGGCATGCAGCTGGTCCAGATGATAGGAAATTAGCCAGGTGGGGACCGAGGGC
AAGGATATATCTGGTGAGAGGCAGGGAACTCAGGGTTAGGTCTTTGGGGCCCTGTGAGGCATAAAATGTC
ACAGCAGCACGTGGTATTTCAGGTCTTACAATACAAGCCTGTGCCCTCAGCTGTGACCCATTTGCACCCA
GAACAACACACTGCTGGTTACAGTTATTTAAGGAAGCATCTTTTCCTGAGGACCTTAATGAAGACCTGTG
CTCACTCCACCCTCCTCTCCTCTCTGTGGTGGCTGCTGCCTGGATTCCAGCTTCAGCCACTGGACTTGGG
ATTTGGAACTGATGCCTGTGGAACTGGGTCTCTGTGAAGAGTGGGGAACCTGCTGAGACTTGTTCTTGGG
AATTGAGCTATAGACTAGAAGATTGTGCAGTAAACAAGAAGAAAGATCACCAAGATCGTGACATTGGAGA
CCTTGCTCTACTTTAATAAAAACTAGAGATAAGTACTGGTCACATTTTGTGGCATTTCCAGGACTGGAAC
TTCCCCAGTCCTTGTTATTTTTGACTCCCCAGATGTTTCCTGAGGATACCCTAGAACTTCATGTCCACCA
GAGGAGACTGCCTTTCCCACATATTCACCTGGACAACCAGAAATGAAAAAGTGCACTTGGAGTGAGTCCT
TGACCCAGGCAGCATTTTATTCTGAGGAAGCTGGAAGGTGAATTCATGAAGGCACTGAAGGCTGCTTCCC
ATGCACAAGACACAGGAAGATAGGAAATGCAGAAGGAGGAGGAGGTGCCGGAGAGGTGAGGACAGGGGCT
GGATGGACGCTGGGTGGAAGGCAGGGCTCGGCACTCCAGTGTACTAAGGGAGTGGAAGGAGAAGGGAGGC
TGGGTGCCAGCCGAGCTCTGAAGGAGATACAAGTCCGTGTCAGCCACTGACTTGAACCAGAGAAGAACGG
GTTCAGGCTTTAGATGATGTGGATGAAGAAACCACTGGGGACATACCATGAGCAGGATTTCCAAGAACAG
AGCTATTTGCACTGCAAACACAGCCAGCTGCTAGCTGCCAGCACAGCTAAGCAGAGACATGGAAATTCTA
GGGGGTTTGGCCAAGAAAAGCCCTGGATGACAATATCAGGAGAATTGCTTGGTTGCTCTGGAGTAACTTT
GATGTGATGAAGCTGAGGTTTCTCTGAAAGAGTGGAAAACCCCAGGGTGTTATGCCGGATTACGGGTCTT
GATCCTCCTTAGCAGGGCAATTGGAACTTCTAAATCCTCTCTACCCACCCCTCCCACTTTAACCTGAATT
CTCCTTTCCATTCCAGCTGCCTCCAAGACGTCAGAGAATTTCCAGCCAAGACAGACGGACTCCAGAATGC
CACTGTGGGACAATTTTGAAGCAAGAAAAATTAACGTGCAAAGTCATCCTGGAGTCTGGGGAAGAAAGAG
GCATTTCCTCATGTTTAACAAGCGTTGGAGCTCAAAGAGTGAGCTTGGGAGCCTGTCCTGTCACGGTTCT
GATGGGACATAGGGTCGCTTACAAATGAAAAGAAACGTTTTGTCACATGGGGCATCATTCCAGGCCTGAA
GTGAGGGAGCCTTTATATTGCCACAGTGTTCATTGTTCCCAGCATTGTTGGGCTCACCTGGAATCCAGAA
CCTACCAAGAGCGGGGAAAAAGATGGATTTACAAAGTGGAAAATCAAAAAGAACTTATTTCCAGTGAAGA
AATGAGTTAACTCAACCCAAGCTTTTGTCCTAGGGAATGGCATAGCAAATGTCTGCACCCAAGCCTCAGA
GGAAGGGGACTGGTGAGACTTCGACCTCTAAGCTTTCACATGCCCCAAGTCCAGGCCAAACCAACCCACC
ACTTTCAAGTCCCTACACAAACCCACACTGTGAAGACCTAGACTCATGACAAGATCCCTGAAGCTGGCCA
GGTAGAAGGCCTTGTTGCCAAACCCCAGAGGGCGTGGAGGGCTCAGGTCCACAGCCAGTTGGTGACAGGG
TTGTGCTCGATCTTGGTTGCAATGTTCCTGTCACTCTAAGACAGGGAAGAATCAGAAACCCTGTCTCATG
GGGAACATCGCCCCCACTCCCTTCATGCCCTGGCCATGGCCGGGGAAAGTCAGGCTGGCACGGAGGGCTC
CAGGGGCTTACCTCACACTTTGGACCTTGTTGAATGGCGTGTCATCCACCCAGGACCAGTCCCCTTCCAT
CCCTGCTTTAGTCAGGCCAATCCAGTAGATGAGTCCCCCCGCTGTTTTATACAGAAACTCCTGTAGGAAA
GACAGGATAAGCAGAGGTGCGGCCACACTTGGAGCTTGATCATCTGTCTCTGGGTGTTCTTCACCTGCGC
TCAGTGACAGCCCTGACCCACAGATGCGCTGCACAAACTGGCCTCTCAAGCTTCTTCCTGCCCTTGCCCA
GAGCCCAGATTTCATCTTCCAGATTATGATGTGTCCCTGCTCTGCAGCTAACAAGCTCAGGACTCAAGCC
TTTCTGCCACTCAGGAAGCAGGTGCTGAAGCACAGGAAGGCCTCAGCTGAACTCCAGAGCACGGACCGCA
AGAGAATGGTTCATATGATAATACCTGAATTAAATGAGCCCTGAATCCACATACGGCACTGTGCTGAGTC
GTCCATATGCATTCTCTCCTTTCCTCTGAGGCAGGTGCCATCACCATGCATGTTTCATCAAGTGAGGGCC
AGTGAAGTTTGCCCAGTGAAGTTGGGTATTCCACCCAAGCTGCTAGGACTAGTTAGATGGCAAGGTTCAG
GCTCTAGAACTACGCCAGAGCCCAGGCTCTGACCTGCTCTGCTATCCCACCTCCCAGATGAAAAGGGCCT
GCCCAATTTCTGCCTCACCAGGCAGGAGACTTCTTGAGTCATGTGGAATCATTAAGGCTGTTCACAAATA
TTTCTTTTTTTCTGGGCACATGGAAAGTAGATCCTCTCTGCCCTGTTCCAGGAGTACTGGAATCCAGGAT
CCTCCCAATCCAGGAGTACTGCATAACTTACTTAACTTAATTAACATAACTTAAGCTAGTGAAATGTAAG
CAAAAATGAGGTATGTTAAATCTGGGCAGAAGCTTTGCACAATATGTCAAGTTCCCCTTTCCTGCCCCAG
CAATTGTGGAGACATATTAAGATGAAGACTCCTTGGGCCTGGGTCCTTGAGTAGCCACAGTGAGCACAGC
CCCCTTGCCGGCCCTTATTCGACATGCTACTGAGAACCAATCCTTCTTCATTAGGTCATCAATATTTGGG
GATTTTTGTTCACGCAGTATAATCTTGCCCATCCTCCCTGGCCCAGTGCTCATACGCCCCCTTCACAGAG
CCCATAGGCACAGCACTCACCTGCTCACTCTCTGAGGTCACCGAGGTCAGGTGTGAATTCCTGGACACAC
AGAACTGCTCGGCACTATACCAGGTCTTTGGAATGAGAGAAAAGTAATAGAAGTTCCCCTTGAAGTACTT
CCAGCCTTGAGAAACCACCTGTAGAATATCATCTAGAGAACAAGAGGTAAAAGTGAACGCTGGTATTCTT
GATTTCTTGGGATGCTGGCTTGGTGGGGGCACTTGAATGAGGTCTCAGAGACAGCAGCAAATGGAGCTGT
GCGCTGGTGTCCTTGGGTCCTTGTATAGGAGATTAGGGACACTCTTTCAAATCCTGAAAGTCAGACAGAG
ACTAATAGAGTCTCTGGGACTGGAGAGGTTATAATGCAAGAGGTTGGACAAAGAGTGTCTTCCCCATGAT
GAGGAAGCAACCCTCCATCGGCCATGACAAGTGGCTGAGCCCCTGGACTCTAGAAAGGAACTTGATGGGA
AATGACTAGGTGTGGGCCAGGGTGGACATCCCCTAATGCTTTTACATTCTGCACTTTTGTGTGGGAGCTC
TAGCTGGACCCTGGTCTCTTTTCTCCTAACAGCCCCTAAGTCCTCCCCAACCTCAAGCCCTCTCTCCTTA
ACTTCCTAGCCCATGGCTGCCCCTCTTTTGCCCCCACTCTCCTCCCCAACCCACCAGCCCAATGGCCTCA
GGTCTGGGACAGGTAAGATCCCATGGGCCACTGGTCAGCTTCAATGTAATTTTCTGAGTCACTTACTTTG
TCGTTTGAGCAACTTGCTCATATTCTCCAAGCTGCCCTGGAGTGCCCGGATCTTTGTATTTAAAGCACTG
GCTTTCTCCAAATCACTTTTTAACTCTGGGATTTGGGCATTTAAGGTACTGACTTCTTCCCAACTTCTTG
TTAAGATCTGGATCTGTGCGTTGGCCTTCTCCACACTGGTTTTTAACTTCAGGAACTGAGAACGCACATA
ACCCAGGCTCTCATTCACCATCTGGATCTGAACGCCAGCTGCCTCCATGCCGTCACTATTCTTTTTAATT
TCAGAATCCAGGGTGCTGATGTTGTCCACACGACCTTTCAGCAACTGGACATTGGTCTTTACATCTGATA
TGGTGCCCATAAACCGGGGATCTGGGATTGAGAAAGTCAGGAGGTCAGCTGAGGGGAGTCCCAGGGACAG
GAGTGGGGGTGTTGTCAGGTTGATCAAAGGAAGGGAAGGAATAGGCTGAAGCTTCCCAAAGAACCAAGAC
AGTCCAATGGGCCACCCCAACCCTCCAATCATTCATTAACGTACAACAAACGTGCAATGGGCACCTACCA
TGTGCCAGGAACACAGGTGGATACAGATAATGGGGAGATTGATAAAACACAGGCTCTCTGTGAAAAGATT
TCACAGGCAAGCAGAAGCAGGAGTTAGAAACCATTCCTGAATTTTCTGAGTGTTCAGGGAACATTTGATA
AAGGGTGCCCTCCATGAGCCCCACCACTGTCCCCAGAACTTGATTCCCCCTAGACCCCACCCCTTGGTTG
CCATCCCTCTGTTTTCAGAAACCCCTGCAGTGGCCATCTGCTAGGACAGCACCACTCCCCCACATCTGTC
CATGGGCCCCTCTGTGACCATGGGAAGAACCAGCCACTAATCTGGAAGTGGCTTCTCCAGAGAACATGGA
AGAGGAGATTACAAAACTGTTTCTCCCCTTCCCTTGCCCCACCCACTTTCACATTCTGCTCAGGTCCCAG
GCCTGGGTACCAGAGAGAGGATCAAAGATAAACCAAGAGGCTCAAAGGCGAGCCCTGAGGAAAATGCGAT
GTTAGAGGCCAGGGGTCTAGGATGGGGCAAGGGGGACTCTGCTCAGAGCCTACAAGTCTAAGCCCAAATA
TGTCCCGAGGCCACAGAGGGAGAAAAAAAAACCCAACAGCTTCTTGGGTCCCTTTGCTCTGCTTCCTGGA
GCCCTGGCAGGAGGAAGAAGGCTCTGCCAGCAGCAAAGGCCATGAAGCCTGACAGAGCCAGAAAAGGAAG
AAAGATAAACCATGCAACATCAAATGAGCAGGAAGCCTCCCTAGATGTGATCTTCACAGGGACAGGAGAA
TGAAGACAGCACCAACGAGTCCTGGGGAGAGGGGACTGAGTCATGGAGATCTGTTGGCTCGTTGGCCAGG
CTCTCCATCTGGTGAGCTGGGGCCAATGATACATGAGGCTCGGTCCTTCACAGGGTCAGGAGACATTGCA
CTGTCAAGGACTGTCCACAAGGCTCTAGATCCAAGGAGCAGAGCTCAGATTGGTGGGGGGTGGACGGGGA
GAAAATAGCACAGGATGTAAAACTAGATCAATGTTTCCTGAGGACAAAAGAATGTATCCTTGAGCACCAA
TGTGCAAATGCTAATCCCAATAATCTCCCAGAAATTGGGAGGGAAAGAGCATCAGCTCACCGTACTGGGG
GCAGCACAGCCTGTTACTGCACATGGAAAGAGGAGGAAGGAGACAAATGAAAAAGCCACAGGCAGGAGAA
ACCCGGAGAGCAGGGAAGTGGTCTCGATCTGAAGGGAGCCGGCTGGCCACAGAGAGGGGCTAAGCCCAGA
CGATGAAACATGAGGACTTACAAAGGACGGCCTGCAGCAGGACGGAGGCGACCAGGACCAGCGTCAGGCA
GATTAATGCAGCACGGACTGTGGGTGTTTTCCCCGGGACCAGAGATGGACCGGACTTGGGAGGAGGCTCT
GTTGGAAGAAGAAGAAAATGTGTGTTGAAGGAGCAGCAAAGGGCAGGTTTGCACACAGAACACGGAGCAG
GTTCTCAGCAGCGATGTGGCTTGCCTCGGGGCCAGAGGGAGATGTTCTGTTTGTCCACAGTGAAGTGCGC
ATCAGGGGCCTCCTTCTCCACAGTCATCCTGAGTGCTCACCCTTATCCTGGGAGCACAGGTGCTTCT
|
| Protein Name |
CLC4K_HUMAN |
| Length |
328 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
21-FEB-2006 |
| Definition |
RecName: Full=C-type lectin domain family 4 member K; AltName: Full=Langerin; AltName: CD_antigen=CD207 |
| Primary Accession |
Q9UJ71 |
| Accession Version |
Q9UJ71.2 |
| Other SeqIDs |
sp|Q9UJ71.2|CLC4K_HUMAN,gi|229784129 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On May 8, 2009 this sequence version replaced Q9UJ71.1.; [FUNCTION] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:17334373, ECO:0000269|PubMed:20026605, ECO:0000269|PubMed:20097424}.; [SUBUNIT] Homotrimer. {ECO:0000269|PubMed:12626394}.; [INTERACTION] Q9UJ71; O43889-2: CREB3; NbExp=3; IntAct=EBI-2873235, EBI-625022; Q9UJ71; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-2873235, EBI-781551; Q9UJ71; Q96HH9: GRAMD2B; NbExp=6; IntAct=EBI-2873235, EBI-2832937; Q9UJ71; O00767: SCD; NbExp=3; IntAct=EBI-2873235, EBI-2684237; Q9UJ71; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-2873235, EBI-8652744; Q9UJ71; Q6PEW1: ZCCHC12; NbExp=3; IntAct=EBI-2873235, EBI-748373.; [SUBCELLULAR LOCATION] Membrane {ECO:0000269|PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269|PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.; [TISSUE SPECIFICITY] Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:20026605}.; [DOMAIN] The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans. {ECO:0000269|PubMed:20026605}.; [DISEASE] Birbeck granule deficiency (BIRGD) [MIM:613393]: A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity. {ECO:0000269|PubMed:15816828, ECO:0000269|PubMed:16567809}. Note=The disease is caused by variants affecting the gene represented in this entry.; [WEB RESOURCE] Name=Functional Glycomics Gateway - Glycan Binding; Note=Langerin; URL='http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00126'. |
| Source Db |
UniProtKB: locus CLC4K_HUMAN, accession Q9UJ71;; class: standard.; created: Feb 21, 2006.; sequence updated: Mar 24, 2009.; annotation updated: Oct 12, 2022.; xrefs: AJ242859.1, CAB62403.1, AC007395.4, BC022278.1, AAH22278.1, NP_056532.4, XP_011531176.1, 3C22_A, 3C22_B, 3C22_C, 3C22_D, 3KQG_A, 3KQG_B, 3KQG_C, 3KQG_D, 3KQG_E, 3KQG_F, 3P5D_A, 3P5D_B, 3P5D_C, 3P5D_D, 3P5E_A, 3P5E_B, 3P5E_C, 3P5E_D, 3P5F_A, 3P5F_B, 3P5F_C, 3P5F_D, 3P5G_A, 3P5G_B, 3P5G_C, 3P5G_D, 3P5H_A, 3P5H_B, 3P5H_C, 3P5H_D, 3P5I_A, 3P5I_B, 3P5I_C, 3P5I_D, 3P7F_A, 3P7F_B, 3P7F_C, 3P7F_D, 3P7G_A, 3P7G_B, 3P7G_C, 3P7G_D, 3P7H_A, 3P7H_B, 3P7H_C, 3P7H_D, 4AK8_A, 4AK8_B, 4AK8_C, 4AK8_D, 4N32_A, 4N32_B, 4N32_C, 4N32_D, 4N33_A, 4N33_B, 4N33_C, 4N33_D, 4N34_A, 4N34_B, 4N34_C, 4N34_D, 4N35_A, 4N35_B, 4N35_C, 4N35_D, 4N36_A, 4N36_B, 4N36_C, 4N36_D, 4N37_A, 4N37_B, 4N37_C, 4N37_D, 4N38_A, 4N38_B, 4N38_C, 4N38_D, 5G6U_A, 5G6U_B, 5G6U_C, 5G6U_D; xrefs (non-sequence databases): CCDS:CCDS74520.1, PDBsum:3C22, PDBsum:3KQG, PDBsum:3P5D, PDBsum:3P5E, PDBsum:3P5F, PDBsum:3P5G, PDBsum:3P5H, PDBsum:3P5I, PDBsum:3P7F, PDBsum:3P7G, PDBsum:3P7H, PDBsum:4AK8, PDBsum:4N32, PDBsum:4N33, PDBsum:4N34, PDBsum:4N35, PDBsum:4N36, PDBsum:4N37, PDBsum:4N38, PDBsum:5G6U, AlphaFoldDB:Q9UJ71, SMR:Q9UJ71, BioGRID:119076, IntAct:Q9UJ71, STRING:9606.ENSP00000386378, BindingDB:Q9UJ71, ChEMBL:CHEMBL2176853, UniLectin:Q9UJ71, GlyGen:Q9UJ71, iPTMnet:Q9UJ71, PhosphoSitePlus:Q9UJ71, BioMuta:CD207, DMDM:229784129, jPOST:Q9UJ71, MassIVE:Q9UJ71, PaxDb:Q9UJ71, PeptideAtlas:Q9UJ71, PRIDE:Q9UJ71, ProteomicsDB:84594, Antibodypedia:2366, DNASU:50489, Ensembl:ENST00000410009.5, Ensembl:ENSP00000386378.3, Ensembl:ENSG00000116031.9, GeneID:50489, KEGG:hsa:50489, MANE-Select:ENST00000410009.5, UCSC:uc002shg.4, CTD:50489, DisGeNET:50489, GeneCards:CD207, HGNC:17935, HPA:ENSG00000116031, MalaCards:CD207, MIM:604862, MIM:613393, neXtProt:NX_Q9UJ71, OpenTargets:ENSG00000116031, PharmGKB:PA134986203, VEuPathDB:HostDB:ENSG00000116031, eggNOG:KOG4297, GeneTree:ENSGT00940000161863, HOGENOM:CLU_081746_0_0_1, InParanoid:Q9UJ71, OMA:QFCVSRN, OrthoDB:988771at2759, PhylomeDB:Q9UJ71, TreeFam:TF333341, PathwayCommons:Q9UJ71, Reactome:R-HSA-1236978, SignaLink:Q9UJ71, BioGRID-ORCS:50489, EvolutionaryTrace:Q9UJ71, GeneWiki:Langerin, GenomeRNAi:50489, Pharos:Q9UJ71, PRO:PR:Q9UJ71, Proteomes:UP000005640, RNAct:Q9UJ71, Bgee:ENSG00000116031, Genevisible:Q9UJ71, GO:0030669, GO:0031901, GO:0030139, GO:0009897, GO:0016021, GO:0005886, GO:0030246, GO:0005537, GO:0051607, CDD:cd03590, Gene3D:3.10.100.10, InterPro:IPR001304, InterPro:IPR016186, InterPro:IPR018378, InterPro:IPR033989, InterPro:IPR016187, Pfam:PF00059, SMART:SM00034, SUPFAM:SSF56436, PROSITE:PS00615, PROSITE:PS50041 |
| Sequence |
mtvekeapdahftvdkqnislwprepppksgpslvpgktptvraalicltlvlvasvllqavlyprfmgtisdvktnvqllkgrvdnistldseikknsdgmeaagvqiqmvneslgyvrsqflklktsvekanaqiqiltrsweevstlnaqipelksdlekasalntkiralqgslenmskllkrqndilqvvsqgwkyfkgnfyyfslipktwysaeqfcvsrnshltsvtseseqeflyktaggliywigltkagmegdwswvddtpfnkvqsvrfwipgepnnagnnehcgnikapslqawndapcdktflfickrpyvpsep |
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