|
|
| Record Information |
| Record ID |
252 |
| Pubmed ID |
31991189 |
| SNP |
|
| Gene ID |
909 |
| Protein ID |
P06126 |
| Vaccine Adverse Events |
|
| Vaccine |
seasonal trivalent influenza vaccine |
| Gene Name |
CD1A |
| Official Symbol |
CD1a molecule [Homo sapiens (human)] |
| Aliases |
CD1, FCB6, HTA1, R4, T6 |
| Other Designations |
T-cell surface glycoprotein CD1a; CD1A antigen, a polypeptide; T-cell surface antigen T6/Leu-6; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; hTa1 thymocyte antigen |
| Chromosome |
1 |
| Location |
1q23.1 |
| Annotation |
Chromosome 1 NC_000001.11 (158248336..158258269) |
| MIM |
188370 |
| DNA Sequence |
>NC_000001.11:158248336-158258269 Homo sapiens chromosome 1, GRCh38.p14 Primary Assembly
ATATCTGGGTTCTGAGGAGAGCTTCAATGGGGAAGGAAGAATTTAGGAGCCATGTTTGCGTTTGGAGGAG
CAACAGGTAAGTGCTGCTACAGTGAACAGGAACATGCTTTTGGCCTGAACACCAATGGTTCAAGAAAGTG
GATCCTGGGGAAAGGTTTGGTGGCAAAGGGAAGAATATGGACTTGCCTAGGATAGCTGGGACACCTGTCT
GATTGAGTTCTAATCAGGGTATATGTTATTCACACTAGTTTGCTTCTCTGGGGTTTCCTGTGTCCAGGGA
GTACAAAATTATCAGTGATTAGTGATAGCCATCCCCTTCTCTCTTAATTATTTTCCTTTTCTCCAGTTCT
GGTCACCTTCCTTACCTATTTTATCTCTTGATTTTTCCCTAGCATTCTGCTCTTTCTCAGCCCCCACCCC
CAATTTCTCAGCACCCCCAGCCAGCTCCCAAGAAGCCCTGTTCCCTTCTGTTCCCTCCTTCAGATCCTGC
CCTGTACCCATCATAGCTGAGTGAACACTCAGGAGTGGAGTTGGCTGGGAAAATTGCAGACCCACAGTAG
GACTACAGCTCTCACCAGCTGCTGCCTGCGTCTCTGATAAAGATCAGCTCTGCCCACAGAAAGCTGGGGT
GGAGATACTTGTGGCTTGGCTCCACTTCTCTTTCCAATCTGTGCCCAACTTCCTCTTCTCCCGCTTCTTC
CTTCTTTAGCATCTTTTATTTCCCTGGTGTTTCTGATCAGCTCATAAAACTTTGGTCCCAGAACTCCATT
TCTCAATTAGTTAATTCTCTTTCTTTTCCTTATCAAACCTAAGCTGACTCCTCTTTGCTTTTCTGACCCC
ATATTCAACGGTGTAGGCCACATAATTTGTGGCGTTGTGCAGAATAGAAATCTGGGGCCCTGTCTTTCTC
CATTCAGGCTGCTACAACAGAATACCACAGACTGGGTGGCTTATAAACAACAGAAATTTATTTCTCACAG
TTTCGGAGGCTGGGAAGTCCAAGATCAAGGAAGATTCAGTGTCTAGTGGAGGCCTGCTTTCTGGTACATA
GAGTACACTTTCTGGATGTGTCCTTACATGGTGGAAGGGGTCAGGGGTCTCTCTTGGGTCTCTTATAAGG
GAACTGATCACATTCATGAGGGCTCCAATCTCATAATCTAATCACCTCCCAAAGGCCCCACTTCCTAATA
ACATAACATTGGGGGTTAGAATTTCAACATATGAATTTTGGGAAGACACAAAGATTCAGAACATAGCAGG
TCTGTATTCAAATAGGCAGGAGAAGAGTGCTTTTAAAGGTATTAAAATATAAAACTTTTTCATTCCTTCT
GAAGTTTCTCTCTCTTTCTGTCTCAACCTGTTATGGTGTTTTGTTTTGTTATTCTTGTTTGTTTAATTTG
CTAATGTTGTACCCCTTGGGCACAGGGATACTCACAGTGTGAGCACAGAGGCTCTTAGGTGCCTGGGGGC
CGCACTCCATGACTCCGGCGCATGCAAGCTGCCCACTGGCTGCTGGGTTCCCCTTGCTGGGAAGAGGAAG
TCAGTCTCTCCTTCCCACAGTGGCCACTCCAACCCTCCACAGATGGGTGACCACCATGAAATTGCAACCA
CTGTATGGAGATGCACTTGATTCTTGGATCAAGGGTGGGAAAGCATGTCGTCCTGATCTGTCTCAAAACA
CTCTGTGGTGCAGCCTGGGTGGGGATGGCTAAAGCCAACCTCTGTGCAGACACTGTGGGATGCATGCCCC
CAAATCTTATTCTCCCTGTGTCCCTGGCAAAAGCAAGGGAATTGTGAAAGGTGATGGCAGAAGGGGCCAC
CTCTGCTGATGAGATCAGACGGCTGTATGGGCAGACAGTGGCAGGGTAGTGGTGGACAGGAGGGCAAGAA
TTGCCTGTGGCCCCAGACATTGGGGAGCAGATGGCAGAGAATCAGTGCTGGGGAGGTGAAGTGATGGGAG
CCAAGACCACATGTCAGCAAAGAAGCCCTCACACAAGTTTTTTTTGGCTCATTTGACTTCATTTATAAAA
CACACATTAAGATAAAATTATGAAGAATTTAAGGATGATGATCATAGGGCATCAACTATGATGCTGCATT
GGTTGCGTGCCCCATGAAGCAAGCCCGGGATATACAATACACCGATTAACTCACTATTTGGGGGATGATC
CTGACTTTGTCTCTTTACAACCTTCGGAAAATTTTGCCTCTTTCAGACTTTCCATCCTACAACTCTGGTT
AGCTCAGTCTTCCCCAACCATTTCTGCCATCTTCCACCTTGGTCTCAGTCATGCGGATGTCTTGTGCCTG
ATCAGACCAATGTTGGTCCTCTCTTCCTATCTCTCTCACCTTTTCATTCCCTGCTCTTTGCATTAACTTG
GGAAACATTTGTGTGTGTATGCTAGCTTTAGTGCCCTCATTTTGTTACCTTGGCGTGAAGTCTGCCGTCC
CTGCAGCTCTATTTCATTTGAATGAGGGAGAAGCCTCATAAAGTTTTAAAAGAGCTTTTTAAGGATTACA
GTCCCTATATCTCTAAGGTTTTCCCAGGACCCATTCCACATGAGAAATCAGGATAAGCTTGCTAAACTTG
TACAGCTGACCCTTGAATAACATGGGGGTTAGGAGTGATGACGGCCCCGTGCAGTCAAAAATCCATGTAT
AACTTTTGACTTTTCCAAATCTTAACTATGAATAGCCTACTATTGGCTGGAAGCCTTACTGCTAACATAA
ACAGTTGATGAACATATATTTTGTATGTTATATGTATTATATATGATATTCTTAAAGTAAGCAAGAGAAA
AGAAAATATTTTAAAGAAAATCAGAAGGGAGAGAAAATATATCTGCTATTTATTAAGTGGATCATCACAT
GTTCGTCTTCATTGTCTTCATGTACAGTAGGCAGAAGAGGAGGAGGAAGAGGAGTTGCCTTGTCTTAGTG
GTGGCAGAGTCAGAAGAAAATCCACGTGTGAGTAAATGCACACAGTTGAAACCCATGTTATTCAAGAGTG
AACTGCAGTGTGAGGGTTTGAGTCAATCTAGTCTGGAGCTAACTGGGTTTGCTGTTTTGCTGTTGCTGCA
ATAGTCTTCAAGTTCCTCTACATTGCTCTGTTCCTAGGGTGGGGCTGGTTTGCCAGAAGGTTTTGTTAAT
GTCTCCACTCTCAGGTTTTGGTGTTTCCTTTGTGAAATATCTCTAGAGGACCTACCTCCATGCTTTCCAT
TCTTCTAGCTGCAGACTCGTCTTGTAATTGATATTTATGATACTGCTTGGGAGAAGGAGTAAGAGCACTG
TCTTTTGTTCTGGTGCAGTCTCATTCTTAGGCAGGTCAGTTGTTTTTGAATTTTTTGAAGTTTTGTCATG
TAAGTGTTCCTGCCTTTCTTCCAGCAGTTTGGGACCTCTAATAGTCTGGAACCAGGATGTTTTCTCGTTC
TTTCCCATTGTTTTTCTTCTCCTCAGCTGCAGTGGGTTTTCACATATGCCCTGAGGGCAGCAGGGCTTTC
TGCCCTTTCCCCACCAGGTTAGGGCTTTTTTTTTTCTTTTAGATGGAATATTGCTCTGTCACCCAGGCTG
GAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTAGCTGAGACTACAGGT
GTGCACCACCACAACTGGCTAATTTTTGTATTATTACTACAGATGGGGTTGCACCATGTTGGCCAGGTTG
GTCTCGAACTCCTGACCTTGTGATCCGCCCACGTTGGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCC
ACCGCACCCGGCCACGGTTTTTTTTTTTTTCTATGTTGCAATAGAGGAGATGGGTCTGGTTGGGACTTAC
TACCCTTCCCATGCAGTAGCTGTTCTCATACCTCAGGCCCGCATCATGAGAGAGGATTTATCTGGTCTAC
ATCTCTGACCCTAATGTTTCAGAAGACCCTGGTGAGGTTCATAGAAAAAGGCTTAGAGACTGATGCGAAT
TTCCCTGTTTTTGTGACTCCCAGGGCTTCTATATACTCATGCTAGCCTTTACTAATTTGTCTAAAATTTT
AGCTGAATTCTTATTCTTACTGGCTTGTATAATATCTGGCATCTGTCCCAAGTAAACAAGGGTTTGCATT
CCATCTGTCCTTTGAGGAGTCTGTCTTTCTTTATATTTTGGGTTAACTGGTTGCCTTGATATTTCAGTTC
TTTGATAAATTCAAGTTATGATTTTGATAATCTGGCTTCAAAAAATTATAAGTATGAAAATGAAGCTCTT
TCCAGCTTTTTGCATGCTAATCTTAACTTTAAAAAAATTATCTGTAATCCCAGCACTTTGGGAGGCTGAG
GCAGGTGGATCATCTGAGGTCAGGAGTTTGAGACCAACATGGTGAAACCCCATCTCTATTAATAATATCA
AAGTTAGCCAGGCATGGTGGTGCATACCTGTAATCCCAGTTACTTGCAAAACCGAGGCAGGACAATTGCT
TTAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCATGCCACTGAACTCCAGCCTGGGTGACAGAGTG
AGACTCTGTCTCAAAACAAAACAAAACAAAACAAAACAAAAAACAAATAAAAAAATTATTTGCAGGCCAT
GCCTGGTGGCTCATGCCAACAATCCCAGCACTTTGGGAGGCTGACACAGGAGGATTGCTTGAGGCCGGGA
GTTGGAGGTTACAGTGAGCTATGATTATTCCACTGCACTCCAGCCTGAGTAACAGAGTGAAACCCTGTCT
CAAGAAAAAAAATTTTTTCCCCCTAAATTAGCTTCAGATACTTTTTTTTTGAAAACCAAAAAATAGTAAA
TAGCCCAGACACATTTATATGGATGATATCTACAAAGCACAAACATATATTTAGAAGCCCTTCAACAGTT
ACAAGCAGCGTAAAAGAGGAATGTAAATGTGTCCGGCAAAGACTCATTTATAACAAAACAACCCTGAAAC
ATCCAAATAGGACTAATAAAAAGGGATCCTGGGATAAAGACTTTGGAATACTCCATTAACTTCACTGCTC
ACAAGTTCTGACTAGTTTCTTATAAGTAATAGGACATTTATAGCAGGATCTTTTATGTAAATCTCATGCC
AGTAACTTGTACTTTTATCCTAAATAAAACTGTATGAGATTCTCATCTCACTACATAGGGTTACAAGTAA
CTTTTATGATATCTTTAAAAAGTTTCATGTTGAATATCACCTCCATAATTAAAAAATGGATGCATAGACT
GAATTCATTCATTCATTTGACAAATATTCACTAAGCACCTACCACTTGTGAGATACTCTGTTAGGTGGGG
ATACAGTATGATAACTGTATGGAACTAACACTCCAAGTCAAACATTGAAGTCAAAATTCTGGGCTGGCGT
ACATTAGTTAGGAGCCCCCATTTTAGAAAATATTATTTCAAGCAGGCCTTGTTTTTATCCAGAGAGTGTA
TACAGTATAATAAAACTCAGTACACCAAGATTTATATTTCATGGCGTGTTTTTCTCCCTAAGTAGAGAAA
AAGCTCCTTCAGTAAAGTGATTGTGTTGTCAACCACTGCATATTCTTAAGTGTACCAAGATGCTTGACTC
CAGGCAGGTGCTAAGAGAGACTGTTGGGTGAGTGAATGTATATCAATGAAAATCAAACAGAGGAAATTTT
CTTTATATGTTTTAGTGTTCCTGTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGTG
ATGGTTACTGGCTCTTCTCTAAGAATAATGGAGAAAAGGTGTTAGTTTGTACTGTCGCACAGGGCAGTCG
TAGGAGACTCTGAAAAAGCAAATAAATCAATGTTAAATCAGAAATGTGAATGTAGTAAGGGGCTGAAGAG
ACAGGGGAAGAGAATACATGGGAAAATATTGAAAAGGACAGAGTGATCAAAAAGAGCAGGGACATGGGAG
CATTGGGCAGCACACTGGGAGCCATTTCACTTTATGCTCTTATTGTATGATTGAGAAAAAAATGTCCTTA
GTGGTTAAGTGGCTTTTCAATGCCACATCAGACTTGTTCCATAGCAGTTGAATTAGGGGAAGGTGAATAA
GTTGGAGGTTGGTGACAAGGAGAGAAGCTGGAACAGAGAGGAGAGTCAGAACCAGAGGGAAATGAGAGAC
TGAGTAGGCATCTCAGGGTTTTTGAAGGAGTGGATTTTCTTTGTTGCAGTCAGGGGAGGTTTGTCTGTTG
GCTGCAGAAAGAAGTCAGAATAGAGATATCGTGGGGTAGGTTTGTTTGGAACAGAAATCAAAGACCAATT
TTTCTGAGAGAAGGAAATAACATCTGCAAATGATATGCTGTTTTTGCTACTTCCATTGTTAGCTGTTCTC
CCAGGTGATGGCAATGCAGACGGTAAGAACTCTGACAACTGCCCAGTTGGGTGGTGGGTGAAGGTCTCTC
TCTCTCTCTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGTTTCCCTAGCA
TATACCTGGAAAGTGAGAGTGCCAGGCTGGTTCCATTCTGACTATCCATGACTCCAGGTCCCTGAGCTCT
TATGAAGGTGGTTGATAAGGCATGGGACTGTGTGGCAAGTGAATGTCTGCTAAGATCATGATGGATCCCC
TTTTCTCCAGATTCTGAGTTCCCGCACTCTGGCACCTTTCTCTCTCCATCCTCTTTCTCAATGTCTTTCT
CCCCATTCTATCTGTTCTTTTGTCGCAGGGCTCAAGGAGCCTCTCTCCTTCCATGTCACCTGGATCGCAT
CCTTTTACAACCATTCCTGGAAACAAAATCTGGTCTCAGGTTGGCTGAGTGATTTGCAGACTCATACCTG
GGACAGCAATTCCAGCACCATCGTTTTCCTGTGCCCCTGGTCCAGGGGAAACTTCAGCAATGAGGAGTGG
AAGGAACTGGAAACATTATTCCGTATACGCACCATTCGGTCATTTGAGGGAATTCGTAGATACGCCCATG
AATTGCAGTTTGAATGTGAGTTCAGTTTTCTCCATGGAGAGTGGTGAGGTGGGAGAGAGGGGTTGTCTCA
ATGTTTCTTATTCCTTTAGGAAACAGCCTGACTCTCTTCTGTATCTTATTCTATTCTTTCCACCATAAAA
CTGCAATTGCATACTTTTGGGCAAGGGCTATCATCCAGACCTTAATTCTCCAAACACTTCTGCTACTTAT
GAACTCCTCTCTCATTGATTGCAGGGTTGTGCATTATTATCTTTTCTTACAGGTATCCCAGGACCACCCT
TCTGCCTGCCCTACAACCAGATACCTTCAGCTTTCTCACTTTCTCATTCATTCTCTTCAGCAGTCTCTCT
ATATATACTCAATTGTAACCCATTGCATTTAATTCAACCTAAGTTGTTATAATCCCAGTTCTCTTACACC
AGGTCCTTGCTCACCCACAGCATTCACATCACCTTCTTTGACCAGTTTGCCCTCTTCCTCATGTTATTAA
TCTTTTCCTCCACCTACAGCTCCCACCAATTCCTCTTTCTCTGAATCCCTGACCAAACCAAATTTTATTC
CATTATGTCAAACCCTGCACACTTCCCCCTTCTGCTTCTATAATCTTTGCTTCTACTCATTTCATTTTAT
ATTTTTTTCTCCCTCTTTCCTCTATTTCATAACCCCAGATCCTTTTGAGATACAGGTGACAGGAGGCTGT
GAGCTGCACTCTGGAAAGGTCTCAGGAAGCTTCTTGCAGTTAGCTTATCAAGGATCAGACTTTGTGAGCT
TCCAGAACAATTCATGGTTGCCATATCCAGTGGCTGGGAATATGGCCAAGCATTTCTGCAAAGTGCTCAA
TCAGAATCAGCATGAAAATGACATAACACACAATCTTCTCAGTGACACCTGCCCACGTTTCATCTTGGGT
CTTCTTGATGCAGGAAAGGCACATCTCCAGCGGCAAGGTCAGTCCTGCACTCTCCCTCCAAGAAGTTTTG
ATTTGAAAATCATACCCTTCCACCACCTCCTTCCAATTTAGAATAAGGAAGAGCCACCCAGAAGTGGGAA
AGGCTGGGTGCAGTGCCTCACATCTGTAATCCCAGTACTTTGGGAAGCTGAGGCTGGAGGACTTCTTAAG
GGCAGGAGTCCCAGACCAGCCTGAGCAACAGAGTGAGACCAGTGTCTCTAAAAAATAAAAATAAGTTAGC
CAGTCATGGTGGTACACACCTGTAGTCCCAGTTACTTAAGAGGCTGAGGCAGGAGGATCGCTTGAGCCTA
ACAGTTTGAGGTTACAGTGAGCTATAATTTATAATTATGCCACTGCATTGCAGCATAGTGACAGAGTGAG
ACCCTGTCTCAAAAAAAAAAAAAAGAGAAATGGGAACAATGTGTCTATCTAAACTTCTAAACTGTTGTGG
AGATATGAAACTCCAAGTCTGTATTTGAATATCTTTTCTGTCCTTTGCAGTGAAGCCCGAGGCCTGGCTG
TCCCATGGCCCCAGTCCTGGCCCTGGCCATCTGCAGCTTGTGTGCCATGTCTCAGGATTCTACCCAAAGC
CCGTGTGGGTGATGTGGATGCGGGGTGAGCAGGAGCAGCAGGGCACTCAGCGAGGGGACATCTTGCCCAG
TGCTGATGGGACATGGTATCTCCGCGCAACCCTGGAGGTGGCCGCTGGGGAGGCAGCTGACCTGTCCTGT
CGGGTGAAGCACAGCAGTCTAGAGGGCCAGGACATCGTCCTCTACTGGGGTGAGAAAAAGCTAAGGCCCA
GGCTGGAAATGCCAGGAAGTGGACCTCAGGCATAGAGGGAGGGCAAGCTGAAAATTTTAGGATTTTAGGG
ATTATAGCCCAAACATGAATAAAAATAGATAATCTAAGAAATGGAAATGTTGAAAATGAGGGCCCTGTAG
ATGCAGGAGGATGCTGAGGGTTAACTGAAGAATCCATCTCTGAGCAGGGATGAGAGAAAAACATAGAAAA
AAAGGAGATTGGTAAGTTGGATACTCAAATGAAAAAAAGAAGCCCAGGGAATGCAGTGAAATAGGGAGTG
GATGAGGTAAAATGGGATGGATTATAACATCCTTGGTGTCTCCCCAAATTCACAGAGCATCACAGTTCCG
TGGGCTTCATCATCTTGGCGGTGATAGTGCCTTTACTTCTTCTGATAGGTCTTGCGCTTTGGTTCAGGAA
ACGCTGGTGAGTTCTTTGCATGTGTCTTTCCTACTCTTAGCCTCTACCCCACTTTTCTTCCCATGTTTTT
TGTTTTTCTCTCCTCAGTTCTTCTCTCCCCAGTCCCCTTCCCTCTTGCTCCTCAATTCTCAGCTCCACCT
TATTCAGAGTGACTTCTATCTCTGTTCTCATCCAGTTTCTGTTAAGACACACCATGAGCCTCCTCGTCAC
CCTTCTCCTTTTGGGGTGAGAGACCAGCAGCCCAAGGGCTCCAGACACACCTGAACACATCGTGATGATG
ACGTCCTCTCAACTCTCTTTGTAAAAATTTTGTTATTTTTGCTTGTTTCTGATTAATGATTGTTTGTCAA
TATAAGCTCAATTTAATTTTGCAGGATTTGTTGTTCTGACCTGGGTTCTGGGACTTTTAAATTCAAATTT
TATCTCCAGATGGAATGGGGTCCTAGCAACCTCCACATGTTCAACTATTAATGGATCATCAGGCCTGTTT
TAGATATCCCTTACTCCAGAGGGCCTTCCCTGACTTACAAGTGGGAAGCAGTCTCTTCCTGGTCTGAACT
CCCGCCACATTTTAGCCGTACTTTGCTAACTGTGCTCCTCACTTCCTCTTCTTCATTGCAGTTATTTAGA
TCCCCCCTTTCCTTCTAATTTTTCAGCTCCTTCAATGCAAAGTACATGTATTTTTAATATATGCATCCCT
GGTGAAGGATCTTGCCTGCATGAAACATGTTCTCAATAAAACTCTGTGTTGAATTTATGCCAAA
|
| Protein Name |
CD1A_HUMAN |
| Length |
327 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-JAN-1988 |
| Definition |
RecName: Full=T-cell surface glycoprotein CD1a; AltName: Full=T-cell surface antigen T6/Leu-6; Short=hTa1 thymocyte antigen; AltName: CD_antigen=CD1a; Flags: Precursor |
| Primary Accession |
P06126 |
| Accession Version |
P06126.4 |
| Other SeqIDs |
sp|P06126.4|CD1A_HUMAN,gi|288558852 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Feb 9, 2010 this sequence version replaced gi:74746210, P06126.3.; [FUNCTION] Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:16272286, ECO:0000269|PubMed:18178838}.; [SUBUNIT] Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74. {ECO:0000269|PubMed:12833155, ECO:0000269|PubMed:15723809, ECO:0000269|PubMed:18178838}.; [INTERACTION] P06126; P61769: B2M; NbExp=2; IntAct=EBI-1036766, EBI-714718.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:11600221, ECO:0000269|PubMed:18178838}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:18178838}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:11231314}; Single-pass type I membrane protein {ECO:0000255}. Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838). {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:18178838}.; [TISSUE SPECIFICITY] Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. {ECO:0000269|PubMed:11231314, ECO:0000269|PubMed:18178838}.; [MISCELLANEOUS] During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. |
| Source Db |
UniProtKB: locus CD1A_HUMAN, accession P06126;; class: standard.; extra accessions:D3DVD7,Q13962,Q5TDJ8,Q9UMM4,Q9Y5M5; created: Jan 1, 1988.; sequence updated: Feb 9, 2010.; annotation updated: Oct 12, 2022.; xrefs: M28825.1, AAA51931.1, M22167.1, AAA51932.1, M22080.1, M22163.1, M22164.1, M22165.1, M22166.1, AK312945.1, BAG35786.1, AL121986.12, CH471121.2, EAW52843.1, EAW52844.1, AF142665.1, AAD37578.1, M27735.1, AAA51933.1, X04450.1, CAA28049.1, M14663.1, AAA51934.1, HLHUCD, NP_001307581.1, NP_001754.2, 1ONQ_A, 1ONQ_C, 1XZ0_A, 1XZ0_C, 4X6C_A, 4X6C_C, 4X6D_A, 4X6D_C, 4X6E_A, 4X6F_A, 5J1A_A, 6NUX_A, 7KOZ_A, 7KP0_A, 7KP1_A; xrefs (non-sequence databases): CCDS:CCDS1174.1, PDBsum:1ONQ, PDBsum:1XZ0, PDBsum:4X6C, PDBsum:4X6D, PDBsum:4X6E, PDBsum:4X6F, PDBsum:5J1A, PDBsum:6NUX, PDBsum:7KOZ, PDBsum:7KP0, PDBsum:7KP1, AlphaFoldDB:P06126, SMR:P06126, BioGRID:107347, IntAct:P06126, STRING:9606.ENSP00000289429, DrugBank:DB00098, GlyGen:P06126, iPTMnet:P06126, PhosphoSitePlus:P06126, SwissPalm:P06126, BioMuta:CD1A, DMDM:288558852, jPOST:P06126, MassIVE:P06126, MaxQB:P06126, PaxDb:P06126, PeptideAtlas:P06126, PRIDE:P06126, ProteomicsDB:51868, ABCD:P06126, Antibodypedia:2533, DNASU:909, Ensembl:ENST00000289429.6, Ensembl:ENSP00000289429.5, Ensembl:ENSG00000158477.7, GeneID:909, KEGG:hsa:909, MANE-Select:ENST00000289429.6, UCSC:uc001frt.4, CTD:909, DisGeNET:909, GeneCards:CD1A, HGNC:1634, HPA:ENSG00000158477, MIM:188370, neXtProt:NX_P06126, OpenTargets:ENSG00000158477, PharmGKB:PA26193, VEuPathDB:HostDB:ENSG00000158477, eggNOG:ENOG502SJH6, GeneTree:ENSGT01060000248559, HOGENOM:CLU_047501_9_2_1, InParanoid:P06126, OMA:QVAGGCE, OrthoDB:827472at2759, PhylomeDB:P06126, TreeFam:TF336723, PathwayCommons:P06126, Reactome:R-HSA-198933, SignaLink:P06126, BioGRID-ORCS:909, EvolutionaryTrace:P06126, GeneWiki:CD1A, GenomeRNAi:909, Pharos:P06126, PRO:PR:P06126, Proteomes:UP000005640, RNAct:P06126, Bgee:ENSG00000158477, Genevisible:P06126, GO:0010008, GO:0009897, GO:0005615, GO:0005887, GO:0045121, GO:0005886, GO:0030883, GO:0030884, GO:0071723, GO:0002250, GO:0048006, GO:0048007, GO:0006955, GO:0001916, Gene3D:2.60.40.10, Gene3D:3.30.500.10, InterPro:IPR007110, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003597, InterPro:IPR011161, InterPro:IPR037055, InterPro:IPR011162, Pfam:PF07654, Pfam:PF16497, SMART:SM00407, SUPFAM:SSF48726, SUPFAM:SSF54452, PROSITE:PS50835 |
| Sequence |
mlflllpllavlpgdgnadglkeplsfhvtwiasfynhswkqnlvsgwlsdlqthtwdsnsstivflcpwsrgnfsneewkeletlfrirtirsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdfvsfqnnswlpypvagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqrqvkpeawlshgpspgpghlqlvchvsgfypkpvwvmwmrgeqeqqgtqrgdilpsadgtwylratlevaageaadlscrvkhsslegqdivlywehhssvgfiilavivplllliglalwfrkrcfc |
|
