|
|
| Record Information |
| Record ID |
247 |
| Pubmed ID |
31991189 |
| SNP |
|
| Gene ID |
6376 |
| Protein ID |
P78423 |
| Vaccine Adverse Events |
|
| Vaccine |
seasonal trivalent influenza vaccine |
| Gene Name |
CX3CL1 |
| Official Symbol |
C-X3-C motif chemokine ligand 1 [Homo sapiens (human)] |
| Aliases |
ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin |
| Other Designations |
fractalkine; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; chemokine (C-X3-C motif) ligand 1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small-inducible cytokine D1 |
| Chromosome |
16 |
| Location |
16q21 |
| Annotation |
Chromosome 16 NC_000016.10 (57372490..57385044) |
| MIM |
601880 |
| DNA Sequence |
>NC_000016.10:57372490-57385044 Homo sapiens chromosome 16, GRCh38.p14 Primary Assembly
AAGGGGACAGCACTGAGCTCTGCCGCCTGGCTCTAGCCGCCTGCCTGGCCCCCGCCGGGACTCTTGCCCA
CCCTCAGCCATGGCTCCGATATCTCTGTCGTGGCTGCTCCGCTTGGCCACCTTCTGCCATCTGACTGTCC
TGCTGGCTGGTAAGTGGGGCTTGACTTGGGCACAAACAGGGTAGGGAGCCCCCAGCCCCTTGTCTATCCC
TCAAGCCTGACATCAGGGGCCCCAGACCCTGCCTGGGTAAAGCTCAAGGCCGGTGGCAGCCGCTTCCCCA
GGGATGTGCGAGAGGGGGCTGGGCACCTCGCTTCCCCCAGATGCAGCGCTGGACAGATTTCCAGTTGCCA
GCGACCGCCCTGCCTGGCCCAGCGAGCAAAGTGGCTGTGCCTGGAAGCACAGAGAGGTGGTGTGGGTGGC
ATAAGGGAGCCAGGTGTGGGTGTGCCAGGAGGGCGGGGGTGGAGAGAGCCTGCAGAAGCTCCTGCTGGGC
ACTGGGGTGGGAGGCCCTGGCTGACAGTGGCTGGCTCTTTCCATCAAGCGTTAATGTGTAACCCGCAGCC
CTGGCCCTGGGCCAGGCCACAGTTGGGACTTTCTCCTGTCCTGTTTTCAAAGCCCCCAGGATTAGGGGGC
CCAGGACCAGTGAAGGTCAAGGTCACTGCAGCTCATGGTTGGGGCTTGCCACTGCTGTGCTAGTCTATAG
CCCCAGTTGCTCTGCCTGTGTCTACCCGTCATGCTGTCTTCCTCCTCCAAGCACAGTGTAGAAAATGCTT
TTGCCTCTAGTCACTTGCTTACTGAAGCCCAGGACCTGGTAGGGGTACATAATTAACCATCCTACCTGAT
ATGGATAAGATGGAGGCCCAGAGAGGTTTAGAAACTGGCCTGACAATGCACAGCCAGCAAGTAGGGCAGG
AGAAGGTAAGACACATGGGACTGAATGCAGGAGAGAGCACAGATGCACACTCACCACCTCTGTGGGCCAC
ATCACCTCCATGAACCGCTAGCCAGCCCCCTCCTCAGGGAGTGCCCCCACCATCTGGCAGGGTGACCTTC
AGAGAAGGTGGGCACACAGCAAGTCTGGGAGAATGAGAAGTAGTCCCCACTGTCCAGATATTTCCATGGA
GCAAACTCACCCTGGGGCAGGGAGCAGGTGTGTGGGTGGGTGGGCACGTGAGAGTGGTGGAGGCAAATTC
CTGCTGGCTTCCTGCTGTCTGGGCTGGGGCCCTGAAGCCTGAGGTGTCTGCGGACAGTGAGATCTGGAAA
GCAGGGAGTCAGATGGCGGCTGCTTTGCCACAGTCCTGTTATGTGACCGTGAGCAGGGTCTTGCCTCCTC
TGGTCCCAGTTGCTGCATCTTTAAATATAGCTATTACCTCTCCGGTGGATTGGGGGAGGGTGACGAGGTT
CCAATGCCTATGGAGGTGTTTTGAAGAGGGCGGAGGAGGAGGATTACTTTTACTAAGCTGAGAGAGGGAA
GGGTCCTAGGCTAGGATGGAAAGGGGACACTGGGGGACCCTGGGTGCTCAGACTAGCAGCCTGAGGCTTT
AGAACCAGGCTTCTGCCCTCATCTTGGTCATTGGCTTTACTGGAAGATCCTGGGCATTATTGGAACCTTT
CTCAGCCTCACTTTCTCCTCCTGTAAAACTAGGCATTTGACCAGGCTCACCTTGGAAGTCCTCTCCCACG
CTGACATGTATGGCTCTGAGAGGCCCTCGGGAGCCCCTGTAGGACAAGGGGGTGGTTTGGAAGCCAGAGA
GACCCCGAGAGGAGGCTGGGGGGTTCGTAGCTGCTGCCCTGACTAGTGTGGGGCAGCTGCGTCAGTCCCC
AAATGTGGGTTTGTGGGGCTGTGTCAGGCAGGAGGCTTCTGTACTTTATATAACAAACCTGCAGCTACGA
GTCAGTGCAGAGCATTGCCCCCCCACTCCAAGAGCTGACGCATTCACTCCCACTCAAGTCCTGGCAAGAA
AGAGAAAAAAAAACGAATCTGTTTTAAGCTCCTATAGCCTACCCGCCTCATTAGCAGTGGGGGTGGATGG
GGAGGGCATGGGAGGATAAATTCAAGAGTGTCAGATCCAGGCCCCTGTCTAATTTAAATAAAAATTCCTC
CATTTTTCTGTTGGTTAAGGTATTATGCCACAAAGCGCTTCCTTAGGCATTTTGTCCATTCATTCAACAA
ATAGTTATTGGACACCTACTGTGTGACAAACCTGGTTCTAGGTACTGGGGCGGCATCAATAAATAAAACA
GCCAAGGACCTCAGCCCTCGAGGTGCTGTAATTCAACTGCAGAGGACACATAACACACAAAGTAAATCAG
TAAACAATGTGGTCTGTTGGAAGGAGAAAAGGCACTGTGATAAAAAAATAGAGAGGGGTGGCTGGGCGCA
GGGGCTCATGCCTGTAATCCCAGCACATTGGGAGGCCAAGGCGGGCAGATCACCTGACGTCAGGAGTTCA
AGACCAGCCTGGCCAACATCATGAAACCCTGTCTCTACTAAAAATATAAAATTAGCTGGGTGTGGTGGTG
CATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATCGCTTGAACCTGGGAGGCAGAGGTTG
GAGTGAGCCGAGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGAGTCCATTTAAAAAAAAAAA
AAAGAAAGAAAAGAAAAGAAAAAGAAAAATAGAGAGGGGAGAAGAGAGGTGTTGACATTTTAAATAGGGG
GTTAGGGAAGCCCACTGAGTAGGTGGCTTTGCACAGTTTGGAGCGGGGTGAGGGCGGGAGCCATGTGGAT
ATCTCTAGAGCAATGGTCCTCAGTGAGTAATTTTGCTCCCCTATGGGCCATTTGGCAATTTCTAGAGAAA
TTTTTTACTTGTTACAAATATCCCAATGTTTTTGGTTCAGTTGAGCTACTCGCCTCTAGTGTGTAGAGGC
CAGAGATGCTGCCAAACCTCCTATAGTACCCGGGACAGCCCCCAAAACAAAGAATTGTCTGGTCCAAAAT
GTCAGTAGTGTCACTGTTGAGAAACCTTGCCCTAAGGGAAAAATGCTCCAGAAGTTAAAAAATTCTTATT
CTCACAACCACACTGTGAAGCAGGTATTGTCACATCCATTTTACAAGTAAGGAAACTGAGGCTCAGGGAG
TCCGAGTGACTTGCTCAGGACACACAGCTGGGCAATGGCTCAAGCCCTCCCTTTATCACCTCATCCAGCA
ACCCAGGACATTTCCTGAGTCTCCTTCTAAGACCCTGGAAGACTCTTAGAAGTCCTTGAGGTCCAGCCTA
AAGGAGAATTCCTCCAAGAAGCCTCCCCTGACCATTTGAAGTTGGAAGTGGTCTCTCCCTCATGTAAACC
CCAATATGTTTGTGGTATGTTCTGGAACACTGTGTTTCTACCTGGCATCTAGGGTAGCCTAGAACAGTGG
GGTGTTTAGGGGCTGAGTAGAAAACTAGCTCTGCCACCATGCAGCTGTGTGGCACTGGGCACATTTAGCC
TCTCTTATTTCCAGCTTCTGCATCTGTAAAGTTGGGATAATACTCCCTTTGCAGGAATGTTGGGAATTAA
AGAGAGCAGATGTGTACATGCTGGACACAGGGTCCAATACACAGTAGGTGTTCAATTAAAAAAAATAAAT
AAAACCTCTGATACTTTGTGTGCCTAATTTACCTGTCCATCAGGCTGGGAGCCTTCTGAGGCCAGAGGCA
TTCCTTGTTCATCTCACTGTACCTCACAGCACCCAGCACAGGGCCTGGCAAGAGGAACCAGCATTTGTTG
GTTGACTGAATAAACAGAGTGATCTGATGGCATTTATTGGGATGGAAGCACTCTCTTCAAACTCAGCACC
AGTGCCTATGGGAGAAAGAGCTCAAGGTTAAGGATAAGAGGGCCTGAGATTTTTGTATATACTCAAAAGT
AATTCCAGCCAGTGTTGGCTGAATCAGGAAGTGGATGGATGGATGGATGGATGGATGGATGGATGGATGG
ATGGATGGATGGGTGGATAGATGGATGAATGGATGGATGGATGGATGGGTGGATGGATGGACAGATGGAT
GGATGGAAGAAGGGATGGGGAGGGGATGATGAGGGATGGATGAGTAGGTGAGATAAAAGGGGGCGGAAGA
TTGACAGGTGGTAGGTAGGGGAGAGGGAGTGGGTAGATGGATGAATGGAGATGAATAGGGGTTGGGCAGG
AGGTGGCAGGTGGGCGAGGAATGGGTAGAAGATTGATAAGAGTGGGTGGACGGGTGGATGGATAGGTAGA
TAGATGCATTAAAGAGAGATAAGTAAACTGAGACTAATTTCATTCAATGAATATTGATTGAGTATCCACC
TTGTGCTTGATGCTGGGAAACTATGATACCAAGACAGACAAGGTCCCTGCCTTCCTGACACTCCTATGAC
AGATAATATATGACTGGCTGGATGAGGCATTGTCTCCATTTACAGAAAGGAAAATTTCAGCTCTGAGAAG
GGACAGGCTCCCCAGGTCAGTTAAACAATCTTCCTGGCAGAACCAAGAACTGAGCCGGGCCAGGACCATT
CAGGGACCGTGGCAGAGGGTGGGGACTTTGGAGACAGGATGACTCTGTGGCTCTTTAAAGCCCTGGAGGT
GGGCAATGGCTTTTCCCATCTTGGATTTGGGGAGCACAGAATGGACCTTCTTTCCTATCCATTGGGCAGC
CTCCCTTGCCTCCTCCTGTCTCTGGTCACTCAGGGGCACCGTATTTTCTGGGGCTTCCCAAAGAAGACAC
CTGCAGGCCATTTTAGGGGACTGCCACCTGGCTCCACTCAATAGGGCCTGGGGAGGCTGCAGGTGAGTCA
GTCTGAGGTTCCATTGCAGAAGGAGGGTGGCCAGCCCACACAGTGACTTTTATATCCTGGTTACTCAGAG
AGAAAGGACAGCCCTGTGACCTGGGGAGCCCCTCCTGCACACAGCCCCCAACCCCCTGAAGCTACTAGTG
CTTCTCCTTGATGACTCAACCCAGACCTGCCGGCCCTAAACCACCTTCCCACAAAGCAGGGTGGGCCAAA
GCTAAGGGGGAGCGATGGAGAGAGGAAGCAGCAGACTCTACAAAGTCTCTCTGTGTGTGCAAGCGTGCAT
GTGCCTGTATTTGGGAAAGTGGTGTATGTTTGCATGGCCACATATATGTAAATATTTATGCATGAGCAGT
TCGTGTTCTGGTGGAGCCCAGGGATGCCCTGGGGGTTTCCCAGGCTCTGAAGGGCTAGATAAGATCAGCT
TGCTCTCTTGACTGCCCTGGTCTCCAGATGTTTGCAAAACCCTCTGGGGTCTTGCTTTTGCTGCATATAA
CCTTGACTCAGATCTGAAACTCAAGCTCTTCCTTGTTTTTTATACTCATCCTCCTTGAGCTCAAGCTAAG
CAGAAGAAAATTTGCTGGAGATTATAGAGGAAGAGAAAAGGTGGAAATTCAATGTAAACAACTTCAAATG
TTTATATCAAATAGTTGGGTTTATTTGTCCTGTCCCGGGGTTTCTCTCTGGTTCCACGTGACACTCAGCT
ACTGCCTGCCCCTTCCGCCCCACTCTGCCCCCACCTTATTCATACCGTCCATCTCCAACCCTCCTCCTTA
CTCTTCTTGCTCCAGGAATTTCAAATGCCTCTTCCCTCCTAGGCAGGATGACTCAGTACCTTTCAGCAAC
TGCTCTCGGGCTCATTCTGGCTCTCAGCAGCAGAACAAAGGATCATCTATTCAGCAGACCCCACCTTCCT
TAGAAAGCAGTTGTACTTATATATTTTTTAAAAAGTTTATTGCTGGGCATAGTGGCTTACATCTGTAATC
CCAGCTATTCCGGAGGTTGAAGTGGGAGAATCACTTGCGGTCGGGGTTCAAGACCAGCCTGGGCAACATA
GCAAGACCCTGTCTCTTAAAAAAATTAGCCAGGCATGGTAGCAGGCACCTGTAGTCCCAGCTACTTGGGA
GGCTGAGGCAAGAGATCTCTTTTTTTTTTTTCTTTTTTTTTTGAGACGGAGTCTTGTTCTGTCACCCAGG
CTTTAGTGCAGTGGTATGATCTCAGCTCACTGCAACCTCTGCCTCCCGGATTCAAGCAATTCTCCTGTCT
CAGCTTCCCGAGTAGCTGGGACTAAAGGTGCACACCATCATGCCAGGCTAATTTGTGTATTTGTAGTAGA
GACAAGGTTTCACCATATTGATCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCTATCTGTCTCGGCC
TCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCCGGCCAGGAGGATTTCTTGAGCCCAGGATTT
TGAGGTTGCCGTGAGCTAGGATTATACCACTGCACTCCAGCCTGGGCAACAGAACAAGACCCTATCTCTT
AAAAAAAAATGGCAGCGGGAAGAAATAAGGCAGAGGTGAGGGGATAGGCAAGGCCACAGGCCCGGTGGGG
ACTAGAGCAGGAGAACCTGCTCCATCACTTGCTGGCTGTGTGACCTTAGCAGGTCCCTGTCACTCTCAGA
TTCATCCCCCCTGCTGCACAATGGACCACTTAATTTTAAAAATTAACTCGGGCATGGTGGCTCACGCCTG
TAATCCCAGCACTTTGGGAGGCCAAGGAGGGCAGATCACCTGAGGTCGGGAGTCTGAGACCAGCCTGACC
AACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCAGGAGTCGTGGCACATGCCTGTAATCC
CAGCTATTCGGGAGTCTGAGGCAGGAGAATCGCTTGAATCTGGGAGGCCGAGGTTGCGGTGAGCCGAGAT
CATGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAGACTCCAACTCAAAAAAAAAAAAATTAAACTCTT
AATATGTGCCAGGCAAAAAGAACTCTATAAATAAGAATTCACGTTTCTTATTCTTACAACAAGACTATGA
GGTAGATGCTATTTTTGTTCCTATTTTACAGGTGGGGAAACTGAGGCATAGAGAAGTTTGGCAGGGGAGG
GAGGCTGAGTCAAAGGCCTTGAAGGCCAGGGTGTACAGGGGATCAGTTTTGGCTTGGGTGGTGTGGCCGG
GACAATCTGGCACGGGGTTGGGAAGCCAGATGCCCACAGACATCCCTGCTGACCAGGAACCTCTTTGAAC
TCAGGACAGCACCACGGTGTGACGAAATGCAACATCACGTGCAGCAAGATGACATCAAAGATACCTGTAG
CTTTGCTCATCCACTATCAACAGAACCAGGCATCATGCGGCAAACGCGCAATCATGTAGGTACTGCCCTC
GAGGCCTCTGAAATCCCCTTTGGGCCCTTGGAATATTCCCAGACCTCTGAGAATCTACGTCCACACCTCC
GCTCCCAGACCTGGGCTCCCAGCCAAAGGCCTCAGCACACGCTTCTCTTGCCCCTGGCCTGCAGGCCACC
TCACTGACCTTAATTTCTGTGCCACATGGCTAAGGTGGAGAGTGGCTTCCTGAATGGCCCAGTGTGGCTG
GGTGGCAGCCACCCTGGCTTGTGGCCTGGAGCAGCCATGAAGGGTGGTAATTCCTCCTGGGCTGAAGCAC
ATGTTACCCCACACTCGAACCCACTATATTTCATGGGGCGGTGTGGGTAGGTGTAAAGCATGAGGGTCTT
ACTTAAAATGCAGGTTCCAGACTCTAACAGACCTGATGCAAATCCTGCCTTCCCTCTTACTGGCTGGGTG
GCCCTGCTTCCATTGCTTACTTTTTGCAACTTGGTTTCCTTGTCTGTAAAATGGGTAGCTAGGACAGGAT
GTAACTAAAGTGCTTGGCAAGGGCGCGGTGGCTAATGCCTGTAATACCAGCACTTTTGAAGGCCGAGGTT
GGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGGCTGGCCAACACGGTGAAACCCCATCTCTACTAAAA
ATACAAAAACTAGCCTGGCATGGTGGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGTTGAGGCAGGAGA
ATCGCTTGAACCCAGGATGCGGAGGTTGCAGTGAGCCAAGATGGCACCACTGCACTCTGGCCTGGGCAAC
ATTGTGAGACTCCATCTCAAAAAAAAGAAAAAGACAAAGAAAAGTAAATAAAGTGCCTGGCAGGGTGCTG
TCAGTAGGAGCTGCAGAAATCACTATCTCCATTGGACAGACAGGAAACGACCATTTCGAGACTTTGGGGA
GGGATTGAGCCATTGTAACCCTGGCTGTTGAAGACCCTGGCAATCTTGGTCACTTGCTCCTCCTGGGGGC
TCTCTTGGGTCCTGTCTAACCAGCCAGCCCTGAGGCCTTTCCCCAGGACTGACTTTTGGGACCTAAAGCA
GCCTCAGCCAGACCTAGAGGCCGGGCAGCAGGAAATGGCCAATGGCCCTTTGCTTTCTAGGCCCAGCTAA
AGGAAGTCTGGCACTTCCTCTCCTCAATTATGCAGTTTCTAAGGTGGGCAAGGTACTGAGTGTGCTCCTG
CCGGACCTCTTTGCTGATCAGTCAAGGCTTACTTCTCCAAGACACCCCCAAGTATTTTTTGTTTTCTAGA
TGAAGGGGAAGAAGGAAGTTGGGGAGGGGATCACTGTGCCCAGGGGGCCTGCAGGGTCATACTTGCTTCC
TGGACTTCTCTGGTTTCCCGGCATCCTGGAGCCAGATGCCTTTACTTCACCTCTCTGAGCCTTGGTTTCC
TCATCTGTAAAATGGGGATGAGCCTGGTAGCCACCTTGTGGAATGGATGTAAGGTTTAGACATGGGCAAA
ATGCCAAGCACAGGCCGTGGCATGGAGCCAGGGCCTCTGTCAGCTCTGAGCTGTGGGCTTGGTGGTGAAC
TAGCCACACAGGGCTTCAGAGGAAGTTCAAGATTTGGAGGGCGCTCGGGATCCCAGTGAGGCTGCCACAT
ATTTGGCTCTAGCCCCTTCTGCCCGTGAACACACATCAGGAGGGGAGGAGAGGGGCCCGGAGCACAGCCT
GTAGCTGTGAAACCGAAGGAGAGGAGCAACAAGACTCACAAAGTCTCATAAGGCCTGTTCCAGAGTGAGG
AGGCCCCATACAGAGCTCACCTGAAGTCCCCCCCAGCAGAAGACTCAAAGCCCAGAGCCCCCTGCCTTAA
TGGTAACAATATTATCGACATTGTTATTATTTTCAGCTATTACTGATCTACTCTGAGCTGGGTGCTTCAC
ATAATTTACCTTTTTTTACAGTAACACAGAAGTAGGGTGATCAACTCGTCCGTGTTTGCCTGGGGACTTC
CCCAGTTTTAAAATGGAAAGTCCCCCATCCTAAGCACCCCCTCCATCCCAATTTTTCTGGGATGGCTGGT
CACCCTACAGATGGGAGGCTTTCCTATCTCCATTTCTAGGGTGAGGACCTGGATGCTCAGGAGAGCGGGT
TGCCCCAGCTGGTCAGTTGCCTCACAGACGCTAAGTGGGAGGACAGGGTTTCCAGCCGGGTGTGTTCACC
TGCAGAGTATTGGTGCTGTGCCCCCACACCACGCTGGCCCGGGTTTCTGGTATCTGGGCATAACCGAATC
CCTGTCTTCCTCCCTTGTAGCTTGGAGACGAGACAGCACAGGCTGTTCTGTGCCGACCCGAAGGAGCAAT
GGGTCAAGGACGCGATGCAGCATCTGGACCGCCAGGCTGCTGCCCTAACTCGAAATGGCGGCACCTTCGA
GAAGCAGATCGGCGAGGTGAAGCCCAGGACCACCCCTGCCGCCGGGGGAATGGACGAGTCTGTGGTCCTG
GAGCCCGAAGCCACAGGCGAAAGCAGTAGCCTGGAGCCGACTCCTTCTTCCCAGGAAGCACAGAGGGCCC
TGGGGACCTCCCCAGAGCTGCCGACGGGCGTGACTGGTTCCTCAGGGACCAGGCTCCCCCCGACGCCAAA
GGCTCAGGATGGAGGGCCTGTGGGCACGGAGCTTTTCCGAGTGCCTCCCGTCTCCACTGCCGCCACGTGG
CAGAGTTCTGCTCCCCACCAACCTGGGCCCAGCCTCTGGGCTGAGGCAAAGACCTCTGAGGCCCCGTCCA
CCCAGGACCCCTCCACCCAGGCCTCCACTGCGTCCTCCCCAGCCCCAGAGGAGAATGCTCCGTCTGAAGG
CCAGCGTGTGTGGGGTCAGGGACAGAGCCCCAGGCCAGAGAACTCTCTGGAGCGGGAGGAGATGGGTCCC
GTGCCAGCGCACACGGATGCCTTCCAGGACTGGGGGCCTGGCAGCATGGCCCACGTCTCTGTGGTCCCTG
TCTCCTCAGAAGGGACCCCCAGCAGGGAGCCAGTGGCTTCAGGCAGCTGGACCCCTAAGGCTGAGGAACC
CATCCATGCCACCATGGACCCCCAGAGGCTGGGCGTCCTTATCACTCCTGTCCCTGACGCCCAGGCTGCC
ACCCGGAGGCAGGCGGTGGGGCTGCTGGCCTTCCTTGGCCTCCTCTTCTGCCTGGGGGTGGCCATGTTCA
CCTACCAGAGCCTCCAGGGCTGCCCTCGAAAGATGGCAGGAGAGATGGCGGAGGGCCTTCGCTACATCCC
CCGGAGCTGTGGTAGTAATTCATATGTCCTGGTGCCCGTGTGAACTCCTCTGGCCTGTGTCTAGTTGTTT
GATTCAGACAGCTGCCTGGGATCCCTCATCCTCATACCCACCCCCACCCAAGGGCCTGGCCTGAGCTGGG
ATGATTGGAGGGGGGAGGTGGGATCCTCCAGGTGCACAAGCTCCAAGCTCCCAGGCATTCCCCAGGAGGC
CAGCCTTGACCATTCTCCACCTGCCAGGGACAGAGGGGGTGGCCTCCCAACTCACCCCAGCCCCAAAACT
CTCCTCTGCTGCTGGCTGGTTAGAGGTTCCCTTTGACGCCATCCCAGCCCCAATGAACAATTATTTATTA
AATGCCCAGCCCCTTCTGACCCATGCTGCCCTGTGAGTACTACAGTCCTCCCATCTCACACATGAGCATC
AGGCCAGGCCCTCTGCCCACTCCCTGCAACCTGATTGTGTCTCTTGGTCCTGCTGCAGTTGCCAGTCACC
CCGGCCACCTGCGGTGCTATCTCCCCCAGCCCCATCCTCTGTACAGAGCCCACGCCCCCACTGGTGACAT
GTCTTTTCTTGCATGAGGCTAGTGTGGTGTTTCCTGGCACTGCTTCCAGTGAGGCTCTGCCCTTGGTTAG
GCATTGTGGGAAGGGGAGATAAGGGTATCTGGTGACTTTCCTCTTTGGTCTACACTGTGCTGAGTCTGAA
GGCTGGGTTCTGATCCTAGTTCCACCATCAAGCCACCAACATACTCCCATCTGTGAAAGGAAAGAGGGAG
GTAAGGAATACCTGTCCCCCTGACAACACTCATTGACCTGAGGCCCTTCTCTCCAGCCCCTGGATGCAGC
CTCACAGTCCTTACCAGCAGAGCACCTTAGACAGTCCCTGCCAATGGACTAACTTGTCTTTGGACCCTGA
GGCCCAGAGGGCCTGCAAGGGAGTGAGTTGATAGCACAGACCCTGCCCTGTGGGCCCCCAAATGGAAATG
GGCAGAGCAGAGACCATCCCTGAAGGCCCCGCCCAGGCTTAGTCACTGAGACAGCCCGGGCTCTGCCTCC
CATCACCCGCTAAGAGGGAGGGAGGGCTCCAGACACATGTCCAAGAAGCCCAGGAAAGGCTCCAGGAGCA
GCCACATTCCTGATGCTTCTTCAGAGACTCCTGCAGGCAGCCAGGCCACAAGACCCTTGTGGTCCCACCC
CACACACGCCAGATTCTTTCCTGAGGCTGGGCTCCCTTCCCACCTCTCTCACTCCTTGAAAACACTGTTC
TCTGCCCTCCAAGACCTTCTCCTTCACCTTTGTCCCCACCGCAGACAGGACCAGGGATTTCCATGATGTT
TTCCATGAGTCCCCTGTTTGTTTCTGAAAGGGACGCTACCCGGGAAGGGGGCTGGGACATGGGAAAGGGG
AAGTTGTAGGCATAAAGTCAGGGGTTCCCTTTTTTGGCTGCTGAAGGCTCGAGCATGCCTGGATGGGGCT
GCACCGGCTGGCCTGGCCCCTCAGGGTCCCTGGTGGCAGCTCACCTCTCCCTTGGATTGTCCCCGACCCT
TGCCGTCTACCTGAGGGGCCTCTTATGGGCTGGGTTCTACCCAGGTGCTAGGAACACTCCTTCACAGATG
GGTGCTTGGAGGAAGGAAACCCAGCTCTGGTCCATAGAGAGCAAGACGCTGTGCTGCCCTGCCCACCTGG
CCTCTGCACTCCCCTGCTGGGTGTGGCGCAGCATATTCAGGAAGCTCAGGGCCTGGCTCAGGTGGGGTCA
CTCTGGCAGCTCAGAGAGGGTGGGAGTGGGCCCAATGCACTTTGTTCTGGCTCTTCCAGGCTGGGAGAGC
CTTCCAGGGGTGGGACACCCTGTGATGGGGCCCTGCCTCCTTTGTGAGGAAGCCGCTGGGGCCAGTTGGT
CCCCCTTCCATGGACTTTGTTAGTTTCTCCAAGCAGGACATGGACAAGGATGATCTAGGAAGACTTTGGA
AAGAGTAGGAAGACTTTGGAAAGACTTTTCCAACCCTCATCACCAACGTCTGTGCCATTTTGTATTTTAC
TAATAAAATTTAAAAGTCTTGTGAA
|
| Protein Name |
X3CL1_HUMAN |
| Length |
397 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
15-JUL-1999 |
| Definition |
RecName: Full=Fractalkine; AltName: Full=C-X3-C motif chemokine 1; AltName: Full=CX3C membrane-anchored chemokine; AltName: Full=Neurotactin; AltName: Full=Small-inducible cytokine D1; Contains: RecName: Full=Processed fractalkine; Flags: Precursor |
| Primary Accession |
P78423 |
| Accession Version |
P78423.1 |
| Other SeqIDs |
sp|P78423.1|X3CL1_HUMAN,gi|6175080 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
[FUNCTION] Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:9782118, PubMed:12055230, PubMed:23125415, PubMed:9931005, PubMed:21829356). The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:9024663, PubMed:9177350, PubMed:9782118, PubMed:12055230). Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (PubMed:23125415, PubMed:24789099). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (PubMed:23125415, PubMed:24789099). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). {ECO:0000269|PubMed:12055230, ECO:0000269|PubMed:21829356, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:9024663, ECO:0000269|PubMed:9177350, ECO:0000269|PubMed:9782118, ECO:0000269|PubMed:9931005}.; [FUNCTION] [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. {ECO:0000269|PubMed:9024663}.; [FUNCTION] [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. {ECO:0000269|PubMed:9024663}.; [SUBUNIT] Monomer (PubMed:9931005). Forms a ternary complex with CX3CR1 and ITGAV:ITGB3 or ITGA4:ITGB1 (PubMed:23125415). {ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:9931005}.; [SUBUNIT] (Microbial infection) Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1. {ECO:0000269|PubMed:21829356}.; [SUBUNIT] (Microbial infection) Interacts (via N-terminus) with human cytomegalovirus (HHV-5) US28. {ECO:0000269|PubMed:25745166}.; [INTERACTION] P78423; P05556: ITGB1; NbExp=2; IntAct=EBI-15188013, EBI-703066; P78423; P05106: ITGB3; NbExp=7; IntAct=EBI-15188013, EBI-702847; P78423; P69332: US28; Xeno; NbExp=4; IntAct=EBI-15188013, EBI-16147206.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:9024663}; Single-pass type I membrane protein {ECO:0000255}.; [SUBCELLULAR LOCATION] [Processed fractalkine]: Secreted {ECO:0000269|PubMed:9024663}.; [TISSUE SPECIFICITY] Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart. {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:9024663, ECO:0000269|PubMed:9177350}.; [INDUCTION] By TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells. {ECO:0000269|PubMed:9024663}.; [PTM] A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. {ECO:0000269|PubMed:9024663}.; [PTM] O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320}.; [SIMILARITY] Belongs to the intercrine delta family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=CX3CL1 entry; URL='https://en.wikipedia.org/wiki/CX3CL1'. |
| Source Db |
UniProtKB: locus X3CL1_HUMAN, accession P78423;; class: standard.; extra accessions:O00672; created: Jul 15, 1999.; sequence updated: May 1, 1997.; annotation updated: Oct 12, 2022.; xrefs: U91835.1, AAB50014.1, U84487.1, AAB49679.1, AC004382.1, AAC24307.1, BC001163.1, AAH01163.1, BC016164.1, AAH16164.1, NP_002987.1, 1B2T_A, 1F2L_A, 1F2L_B, 1F2L_C, 1F2L_D, 3ONA_B, 4XT1_B, 4XT3_B, 5WB2_B, 7RKF_L, 7RKM_L, 7RKN_L; xrefs (non-sequence databases): CCDS:CCDS10779.1, PDBsum:1B2T, PDBsum:1F2L, PDBsum:3ONA, PDBsum:4XT1, PDBsum:4XT3, PDBsum:5WB2, PDBsum:7RKF, PDBsum:7RKM, PDBsum:7RKN, AlphaFoldDB:P78423, SMR:P78423, BioGRID:112278, DIP:DIP-5878N, IntAct:P78423, STRING:9606.ENSP00000006053, ChEMBL:CHEMBL4630883, GlyConnect:698, GlyGen:P78423, iPTMnet:P78423, PhosphoSitePlus:P78423, BioMuta:CX3CL1, DMDM:6175080, MassIVE:P78423, PaxDb:P78423, PeptideAtlas:P78423, PRIDE:P78423, ProteomicsDB:57622, ABCD:P78423, Antibodypedia:15022, CPTC:P78423, DNASU:6376, Ensembl:ENST00000006053.7, Ensembl:ENSP00000006053.6, Ensembl:ENSG00000006210.7, GeneID:6376, KEGG:hsa:6376, MANE-Select:ENST00000006053.7, UCSC:uc002eli.4, CTD:6376, DisGeNET:6376, GeneCards:CX3CL1, HGNC:10647, HPA:ENSG00000006210, MIM:601880, neXtProt:NX_P78423, OpenTargets:ENSG00000006210, PharmGKB:PA35577, VEuPathDB:HostDB:ENSG00000006210, eggNOG:ENOG502SNIE, GeneTree:ENSGT01060000248576, InParanoid:P78423, OrthoDB:1060256at2759, PhylomeDB:P78423, TreeFam:TF337534, PathwayCommons:P78423, Reactome:R-HSA-380108, Reactome:R-HSA-418594, SignaLink:P78423, SIGNOR:P78423, BioGRID-ORCS:6376, EvolutionaryTrace:P78423, GeneWiki:CX3CL1, GenomeRNAi:6376, Pharos:P78423, PRO:PR:P78423, Proteomes:UP000005640, RNAct:P78423, Bgee:ENSG00000006210, ExpressionAtlas:P78423, Genevisible:P78423, GO:0042995, GO:0009986, GO:0005576, GO:0005615, GO:0016021, GO:0016020, GO:0043005, GO:0043025, GO:0048471, GO:0005886, GO:0048020, GO:0042056, GO:0008009, GO:0031737, GO:0045237, GO:0005178, GO:0005102, GO:0007568, GO:0060055, GO:0035425, GO:0007155, GO:0060326, GO:0098609, GO:0007267, GO:0071346, GO:0071347, GO:0071356, GO:0070098, GO:0006935, GO:0019221, GO:0006952, GO:0048245, GO:0097192, GO:0007186, GO:0006955, GO:0006954, GO:0033622, GO:0050902, GO:0030595, GO:0002523, GO:0048247, GO:0001774, GO:0061518, GO:0002548, GO:0043066, GO:2001234, GO:0030336, GO:0010812, GO:2001240, GO:1900450, GO:0110091, GO:0032690, GO:0032691, GO:0032715, GO:1903979, GO:2001223, GO:0032720, GO:0070050, GO:0016322, GO:0030593, GO:0050918, GO:0032233, GO:0051041, GO:0008284, GO:0001954, GO:0070374, GO:0043547, GO:0043123, GO:1903721, GO:0050729, GO:0043410, GO:1904141, GO:0002052, GO:0010976, GO:0051092, GO:0051897, GO:0051281, GO:0048661, GO:0045944, GO:0032914, GO:0031664, GO:0050767, GO:0048167, GO:0002931, GO:0098883, CDD:cd00274, InterPro:IPR039809, InterPro:IPR034127, InterPro:IPR001811, InterPro:IPR008097, InterPro:IPR036048, PANTHER:PTHR12015, PANTHER:PTHR12015:SF92, Pfam:PF00048, SMART:SM00199, SUPFAM:SSF54117 |
| Sequence |
mapislswllrlatfchltvllagqhhgvtkcnitcskmtskipvallihyqqnqascgkraiiletrqhrlfcadpkeqwvkdamqhldrqaaaltrnggtfekqigevkprttpaaggmdesvvlepeatgesssleptpssqeaqralgtspelptgvtgssgtrlpptpkaqdggpvgtelfrvppvstaatwqssaphqpgpslwaeaktseapstqdpstqastasspapeenapsegqrvwgqgqsprpenslereemgpvpahtdafqdwgpgsmahvsvvpvssegtpsrepvasgswtpkaeepihatmdpqrlgvlitpvpdaqaatrrqavgllaflgllfclgvamftyqslqgcprkmagemaeglryiprscgsnsyvlvpv |
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