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|
| Record Information |
| Record ID |
240 |
| Pubmed ID |
27866772 |
| SNP |
|
| Gene ID |
7124 |
| Protein ID |
P01375 |
| Vaccine Adverse Events |
tenderness, headache, elevated creatinine kinase, fatigue |
| Vaccine |
H1:IC31 vaccine |
| Gene Name |
TNF |
| Official Symbol |
tumor necrosis factor [Homo sapiens (human)] |
| Aliases |
DIF-alpha, TNFA, TNFSF2, TNLG1F, TNF |
| Other Designations |
tumor necrosis factor; APC1 protein; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha; tumor necrotic factor alpha |
| Chromosome |
6 |
| Location |
6p21.33 |
| Annotation |
Chromosome 6 NC_000006.12 (31575565..31578336) |
| MIM |
191160 |
| DNA Sequence |
>NC_000006.12:31575565-31578336 Homo sapiens chromosome 6, GRCh38.p14 Primary Assembly
AGCAGACGCTCCCTCAGCAAGGACAGCAGAGGACCAGCTAAGAGGGAGAGAAGCAACTACAGACCCCCCC
TGAAAACAACCCTCAGACGCCACATCCCCTGACAAGCTGCCAGGCAGGTTCTCTTCCTCTCACATACTGA
CCCACGGCTCCACCCTCTCTCCCCTGGAAAGGACACCATGAGCACTGAAAGCATGATCCGGGACGTGGAG
CTGGCCGAGGAGGCGCTCCCCAAGAAGACAGGGGGGCCCCAGGGCTCCAGGCGGTGCTTGTTCCTCAGCC
TCTTCTCCTTCCTGATCGTGGCAGGCGCCACCACGCTCTTCTGCCTGCTGCACTTTGGAGTGATCGGCCC
CCAGAGGGAAGAGGTGAGTGCCTGGCCAGCCTTCATCCACTCTCCCACCCAAGGGGAAATGGAGACGCAA
GAGAGGGAGAGAGATGGGATGGGTGAAAGATGTGCGCTGATAGGGAGGGATGGAGAGAAAAAAACGTGGA
GAAAGACGGGGATGCAGAAAGAGATGTGGCAAGAGATGGGGAAGAGAGAGAGAGAAAGATGGAGAGACAG
GATGTCTGGCACATGGAAGGTGCTCACTAAGTGTGTATGGAGTGAATGAATGAATGAATGAATGAACAAG
CAGATATATAAATAAGATATGGAGACAGATGTGGGGTGTGAGAAGAGAGATGGGGGAAGAAACAAGTGAT
ATGAATAAAGATGGTGAGACAGAAAGAGCGGGAAATATGACAGCTAAGGAGAGAGATGGGGGAGATAAGG
AGAGAAGAAGATAGGGTGTCTGGCACACAGAAGACACTCAGGGAAAGAGCTGTTGAATGCCTGGAAGGTG
AATACACAGATGAATGGAGAGAGAAAACCAGACACCTCAGGGCTAAGAGCGCAGGCCAGACAGGCAGCCA
GCTGTTCCTCCTTTAAGGGTGACTCCCTCGATGTTAACCATTCTCCTTCTCCCCAACAGTTCCCCAGGGA
CCTCTCTCTAATCAGCCCTCTGGCCCAGGCAGTCAGTAAGTGTCTCCAAACCTCTTTCCTAATTCTGGGT
TTGGGTTTGGGGGTAGGGTTAGTACCGGTATGGAAGCAGTGGGGGAAATTTAAAGTTTTGGTCTTGGGGG
AGGATGGATGGAGGTGAAAGTAGGGGGGTATTTTCTAGGAAGTTTAAGGGTCTCAGCTTTTTCTTTTCTC
TCTCCTCTTCAGGATCATCTTCTCGAACCCCGAGTGACAAGCCTGTAGCCCATGTTGTAGGTAAGAGCTC
TGAGGATGTGTCTTGGAACTTGGAGGGCTAGGATTTGGGGATTGAAGCCCGGCTGATGGTAGGCAGAACT
TGGAGACAATGTGAGAAGGACTCGCTGAGCTCAAGGGAAGGGTGGAGGAACAGCACAGGCCTTAGTGGGA
TACTCAGAACGTCATGGCCAGGTGGGATGTGGGATGACAGACAGAGAGGACAGGAACCGGATGTGGGGTG
GGCAGAGCTCGAGGGCCAGGATGTGGAGAGTGAACCGACATGGCCACACTGACTCTCCTCTCCCTCTCTC
CCTCCCTCCAGCAAACCCTCAAGCTGAGGGGCAGCTCCAGTGGCTGAACCGCCGGGCCAATGCCCTCCTG
GCCAATGGCGTGGAGCTGAGAGATAACCAGCTGGTGGTGCCATCAGAGGGCCTGTACCTCATCTACTCCC
AGGTCCTCTTCAAGGGCCAAGGCTGCCCCTCCACCCATGTGCTCCTCACCCACACCATCAGCCGCATCGC
CGTCTCCTACCAGACCAAGGTCAACCTCCTCTCTGCCATCAAGAGCCCCTGCCAGAGGGAGACCCCAGAG
GGGGCTGAGGCCAAGCCCTGGTATGAGCCCATCTATCTGGGAGGGGTCTTCCAGCTGGAGAAGGGTGACC
GACTCAGCGCTGAGATCAATCGGCCCGACTATCTCGACTTTGCCGAGTCTGGGCAGGTCTACTTTGGGAT
CATTGCCCTGTGAGGAGGACGAACATCCAACCTTCCCAAACGCCTCCCCTGCCCCAATCCCTTTATTACC
CCCTCCTTCAGACACCCTCAACCTCTTCTGGCTCAAAAAGAGAATTGGGGGCTTAGGGTCGGAACCCAAG
CTTAGAACTTTAAGCAACAAGACCACCACTTCGAAACCTGGGATTCAGGAATGTGTGGCCTGCACAGTGA
AGTGCTGGCAACCACTAAGAATTCAAACTGGGGCCTCCAGAACTCACTGGGGCCTACAGCTTTGATCCCT
GACATCTGGAATCTGGAGACCAGGGAGCCTTTGGTTCTGGCCAGAATGCTGCAGGACTTGAGAAGACCTC
ACCTAGAAATTGACACAAGTGGACCTTAGGCCTTCCTCTCTCCAGATGTTTCCAGACTTCCTTGAGACAC
GGAGCCCAGCCCTCCCCATGGAGCCAGCTCCCTCTATTTATGTTTGCACTTGTGATTATTTATTATTTAT
TTATTATTTATTTATTTACAGATGAATGTATTTATTTGGGAGACCGGGGTATCCTGGGGGACCCAATGTA
GGAGCTGCCTTGGCTCAGACATGTTTTCCGTGAAAACGGAGCTGAACAATAGGCTGTTCCCATGTAGCCC
CCTGGCCTCTGTGCCTTCTTTTGATTATGTTTTTTAAAATATTTATCTGATTAAGTTGTCTAAACAATGC
TGATTTGGTGACCAACTGTCACTCATTGCTGAGCCTCTGCTCCCCAGGGGAGTTGTGTCTGTAATCGCCC
TACTATTCAGTGGCGAGAAATAAAGTTTGCTTAGAAAAGAAA
|
| Protein Name |
TNFA_HUMAN |
| Length |
233 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
21-JUL-1986 |
| Definition |
RecName: Full=Tumor necrosis factor; AltName: Full=Cachectin; AltName: Full=TNF-alpha; AltName: Full=Tumor necrosis factor ligand superfamily member 2; Short=TNF-a; Contains: RecName: Full=Tumor necrosis factor, membrane form; AltName: Full=N-terminal fragment; Short=NTF; Contains: RecName: Full=Intracellular domain 1; Short=ICD1; Contains: RecName: Full=Intracellular domain 2; Short=ICD2; Contains: RecName: Full=C-domain 1; Contains: RecName: Full=C-domain 2; Contains: RecName: Full=Tumor necrosis factor, soluble form; Flags: Precursor |
| Primary Accession |
P01375 |
| Accession Version |
P01375.1 |
| Other SeqIDs |
sp|P01375.1|TNFA_HUMAN,gi|135934 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Mar 15, 2005 this sequence version replaced gi:69405.; [FUNCTION] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819). {ECO:0000250|UniProtKB:P06804, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:22517918, ECO:0000269|PubMed:23396208}.; [FUNCTION] The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000269|PubMed:16829952}.; [SUBUNIT] Homotrimer. Interacts with SPPL2B. {ECO:0000269|PubMed:16829951}.; [INTERACTION] P01375; P05067: APP; NbExp=3; IntAct=EBI-359977, EBI-77613; P01375; Q92482: AQP3; NbExp=3; IntAct=EBI-359977, EBI-2808854; P01375; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-359977, EBI-747430; P01375; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-359977, EBI-17953245; P01375; Q8IYJ2-2: C10orf67; NbExp=3; IntAct=EBI-359977, EBI-13381098; P01375; Q8WV48: CCDC107; NbExp=3; IntAct=EBI-359977, EBI-947033; P01375; Q6NSX1: CCDC70; NbExp=3; IntAct=EBI-359977, EBI-6873045; P01375; O95471: CLDN7; NbExp=3; IntAct=EBI-359977, EBI-740744; P01375; Q8IUN9: CLEC10A; NbExp=3; IntAct=EBI-359977, EBI-2873246; P01375; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-359977, EBI-6942903; P01375; P00387: CYB5R3; NbExp=3; IntAct=EBI-359977, EBI-1046040; P01375; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-359977, EBI-18304435; P01375; O15552: FFAR2; NbExp=3; IntAct=EBI-359977, EBI-2833872; P01375; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-359977, EBI-12142257; P01375; Q9Y6K9: IKBKG; NbExp=3; IntAct=EBI-359977, EBI-81279; P01375; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-359977, EBI-749265; P01375; Q8N386: LRRC25; NbExp=3; IntAct=EBI-359977, EBI-11304917; P01375; O43300: LRRTM2; NbExp=3; IntAct=EBI-359977, EBI-18096461; P01375; Q9HC36: MRM3; NbExp=3; IntAct=EBI-359977, EBI-1045440; P01375; O75459: PAGE1; NbExp=3; IntAct=EBI-359977, EBI-2559100; P01375; Q96RD7: PANX1; NbExp=3; IntAct=EBI-359977, EBI-7037612; P01375; Q8N4L2: PIP4P2; NbExp=3; IntAct=EBI-359977, EBI-2820617; P01375; Q53GL0: PLEKHO1; NbExp=3; IntAct=EBI-359977, EBI-949945; P01375; Q6ZMZ0: RNF19B; NbExp=3; IntAct=EBI-359977, EBI-2466594; P01375; Q16585: SGCB; NbExp=3; IntAct=EBI-359977, EBI-5663627; P01375; Q15849: SLC14A2; NbExp=3; IntAct=EBI-359977, EBI-1573290; P01375; O14863: SLC30A4; NbExp=3; IntAct=EBI-359977, EBI-13918058; P01375; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-359977, EBI-17280858; P01375; P27105: STOM; NbExp=3; IntAct=EBI-359977, EBI-1211440; P01375; Q16623: STX1A; NbExp=4; IntAct=EBI-359977, EBI-712466; P01375; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-359977, EBI-12345267; P01375; P01375: TNF; NbExp=3; IntAct=EBI-359977, EBI-359977; P01375; P19438: TNFRSF1A; NbExp=15; IntAct=EBI-359977, EBI-299451; P01375; P20333: TNFRSF1B; NbExp=2; IntAct=EBI-359977, EBI-358983; P01375; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-359977, EBI-744988; P01375; Q6PEW1: ZCCHC12; NbExp=3; IntAct=EBI-359977, EBI-748373; P01375; Q9DHW0: 2L; Xeno; NbExp=2; IntAct=EBI-359977, EBI-15810797; P01375; O89110: Casp8; Xeno; NbExp=2; IntAct=EBI-359977, EBI-851690; P01375; Q8UYL3: crmE; Xeno; NbExp=3; IntAct=EBI-359977, EBI-7539950; P01375; O88351: Ikbkb; Xeno; NbExp=3; IntAct=EBI-359977, EBI-447960; P01375; Q60855: Ripk1; Xeno; NbExp=3; IntAct=EBI-359977, EBI-529119; P01375; Q60769: Tnfaip3; Xeno; NbExp=2; IntAct=EBI-359977, EBI-646595; P01375; P25118: Tnfrsf1a; Xeno; NbExp=3; IntAct=EBI-359977, EBI-518014; P01375; Q3U0V2: Tradd; Xeno; NbExp=2; IntAct=EBI-359977, EBI-1544032.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:16829952}; Single-pass type II membrane protein {ECO:0000269|PubMed:16829952}.; [SUBCELLULAR LOCATION] [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein.; [SUBCELLULAR LOCATION] [Tumor necrosis factor, soluble form]: Secreted {ECO:0000269|PubMed:23552949}.; [SUBCELLULAR LOCATION] [C-domain 1]: Secreted.; [SUBCELLULAR LOCATION] [C-domain 2]: Secreted.; [PTM] The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:9034191}.; [PTM] The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. {ECO:0000269|PubMed:10205166, ECO:0000269|PubMed:8597870}.; [PTM] O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. {ECO:0000269|PubMed:8631363}.; [PTM] [Tumor necrosis factor, soluble form]: The soluble form is demyristoylated at Lys-19 and Lys-20 by SIRT6, promoting its secretion. {ECO:0000269|PubMed:23552949}.; [POLYMORPHISM] Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].; [POLYMORPHISM] Genetic variations in TNF are involved in susceptibility to malaria [MIM:611162].; [DISEASE] Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269|PubMed:12746914}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the tumor necrosis factor family. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=AAF71992.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA75070.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Tumor necrosis factor alpha entry; URL='https://en.wikipedia.org/wiki/Tumor_necrosis_factor-alpha'.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/TNFaID319.html'.; [WEB RESOURCE] Name=NIEHS-SNPs; URL='http://egp.gs.washington.edu/data/tnf/'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/tnf/'. |
| Source Db |
UniProtKB: locus TNFA_HUMAN, accession P01375;; class: standard.; extra accessions:O43647,Q9P1Q2,Q9UIV3; created: Jul 21, 1986.; sequence updated: Jul 21, 1986.; annotation updated: Oct 12, 2022.; xrefs: M16441.1, AAA61200.1, X02910.1, CAA26669.1, X01394.1, CAA25650.1, M10988.1, AAA61198.1, M26331.1, AAA36758.1, Z15026.1, CAA78745.1, Y14768.1, CAA75070.1, AF129756.1, AAD18091.1, BA000025.2, BAB63396.1, AB088112.1, BAC54944.1, AY066019.1, AAL47581.1, AY214167.1, AAO21132.1, BC028148.1, AAH28148.1, AF043342.1, AAC03542.1, AF098751.1, AAF71992.1, QWHUN, NP_000585.2, 1A8M_A, 1A8M_B, 1A8M_C, 1TNF_A, 1TNF_B, 1TNF_C, 2AZ5_A, 2AZ5_B, 2AZ5_C, 2AZ5_D, 2E7A_A, 2E7A_B, 2E7A_C, 2TUN_A, 2TUN_B, 2TUN_C, 2TUN_D, 2TUN_E, 2TUN_F, 2ZJC_A, 2ZJC_B, 2ZJC_C, 2ZPX_A, 2ZPX_B, 2ZPX_C, 3ALQ_A, 3ALQ_B, 3ALQ_C, 3ALQ_D, 3ALQ_E, 3ALQ_F, 3IT8_A, 3IT8_B, 3IT8_C, 3IT8_G, 3IT8_H, 3IT8_I, 3L9J_T, 3WD5_A, 4G3Y_C, 4TSV_A, 4TWT_A, 4TWT_B, 4TWT_C, 4TWT_D, 4Y6O_C, 4Y6O_D, 5M2I_A, 5M2I_B, 5M2I_C, 5M2I_D, 5M2I_E, 5M2I_F, 5M2J_A, 5M2M_A, 5M2M_B, 5M2M_C, 5M2M_G, 5M2M_I, 5M2M_M, 5MU8_A, 5MU8_B, 5MU8_C, 5MU8_D, 5MU8_F, 5MU8_G, 5MU8_H, 5MU8_I, 5MU8_J, 5MU8_K, 5MU8_L, 5MU8_M, 5MU8_N, 5MU8_O, 5MU8_P, 5MU8_Q, 5MU8_R, 5MU8_S, 5MU8_T, 5MU8_U, 5MU8_V, 5MU8_W, 5MU8_X, 5MU8_Y, 5MU8_Z, 5MU8_AA, 5MU8_BB, 5MU8_CC, 5MU8_DD, 5MU8_EE, 5TSW_A, 5TSW_B, 5TSW_C, 5TSW_D, 5TSW_E, 5TSW_F, 5UUI_A, 5WUX_E, 5WUX_F, 5WUX_G, 5YOY_A, 5YOY_B, 5YOY_C, 5YOY_J, 5YOY_K, 5YOY_L, 6OOY_A, 6OOY_B, 6OOY_C, 6OOZ_A, 6OOZ_B, 6OOZ_C, 6OP0_A, 6OP0_B, 6OP0_C, 6RMJ_A, 6RMJ_B, 6RMJ_C, 6X81_A, 6X81_B, 6X81_C, 6X81_D, 6X81_E, 6X81_F, 6X82_A, 6X82_B, 6X82_C, 6X82_D, 6X82_E, 6X82_F, 6X83_A, 6X83_B, 6X83_C, 6X83_D, 6X83_E, 6X83_F, 6X85_A, 6X85_B, 6X85_C, 6X85_D, 6X85_E, 6X85_F, 6X86_A, 6X86_B, 6X86_C, 6X86_D, 6X86_E, 6X86_F, 7ASY_A, 7AT7_A, 7ATB_A, 7JRA_A, 7JRA_B, 7JRA_C, 7KP9_A, 7KP9_B, 7KP9_C, 7KPA_A, 7KPA_B, 7KPA_C, 7KPB_A, 7KPB_B, 7KPB_C; xrefs (non-sequence databases): CCDS:CCDS4702.1, PDBsum:1A8M, PDBsum:1TNF, PDBsum:2AZ5, PDBsum:2E7A, PDBsum:2TUN, PDBsum:2ZJC, PDBsum:2ZPX, PDBsum:3ALQ, PDBsum:3IT8, PDBsum:3L9J, PDBsum:3WD5, PDBsum:4G3Y, PDBsum:4TSV, PDBsum:4TWT, PDBsum:4Y6O, PDBsum:5M2I, PDBsum:5M2J, PDBsum:5M2M, PDBsum:5MU8, PDBsum:5TSW, PDBsum:5UUI, PDBsum:5WUX, PDBsum:5YOY, PDBsum:6OOY, PDBsum:6OOZ, PDBsum:6OP0, PDBsum:6RMJ, PDBsum:6X81, PDBsum:6X82, PDBsum:6X83, PDBsum:6X85, PDBsum:6X86, PDBsum:7ASY, PDBsum:7AT7, PDBsum:7ATB, PDBsum:7JRA, PDBsum:7KP9, PDBsum:7KPA, PDBsum:7KPB, AlphaFoldDB:P01375, SMR:P01375, BioGRID:112979, CORUM:P01375, DIP:DIP-2895N, IntAct:P01375, MINT:P01375, STRING:9606.ENSP00000398698, BindingDB:P01375, ChEMBL:CHEMBL1825, DrugBank:DB00051, DrugBank:DB04956, DrugBank:DB05879, DrugBank:DB01427, DrugBank:DB05767, DrugBank:DB05513, DrugBank:DB11967, DrugBank:DB11752, DrugBank:DB08904, DrugBank:DB00608, DrugBank:DB01407, DrugBank:DB05744, DrugBank:DB05758, DrugBank:DB06444, DrugBank:DB12140, DrugBank:DB00668, DrugBank:DB00005, DrugBank:DB05869, DrugBank:DB10770, DrugBank:DB10772, DrugBank:DB13751, DrugBank:DB06674, DrugBank:DB00065, DrugBank:DB05303, DrugBank:DB06495, DrugBank:DB05992, DrugBank:DB05218, DrugBank:DB09221, DrugBank:DB08910, DrugBank:DB05968, DrugBank:DB01411, DrugBank:DB00852, DrugBank:DB05207, DrugBank:DB05412, DrugBank:DB01041, DrugBank:DB05470, DrugBank:DB05017, DrugCentral:P01375, GlyConnect:609, GlyGen:P01375, iPTMnet:P01375, PhosphoSitePlus:P01375, SwissPalm:P01375, BioMuta:TNF, DMDM:135934, MassIVE:P01375, PaxDb:P01375, PeptideAtlas:P01375, PRIDE:P01375, ProteomicsDB:51379, ABCD:P01375, Antibodypedia:27196, DNASU:7124, Ensembl:ENST00000376122.3, Ensembl:ENSP00000365290.3, Ensembl:ENSG00000204490.3, Ensembl:ENST00000383496.4, Ensembl:ENSP00000372988.4, Ensembl:ENSG00000206439.5, Ensembl:ENST00000412275.2, Ensembl:ENSP00000392858.2, Ensembl:ENSG00000228321.3, Ensembl:ENST00000420425.2, Ensembl:ENSP00000410668.2, Ensembl:ENSG00000228849.3, Ensembl:ENST00000443707.2, Ensembl:ENSP00000389492.2, Ensembl:ENSG00000230108.3, Ensembl:ENST00000448781.2, Ensembl:ENSP00000389490.2, Ensembl:ENSG00000223952.3, Ensembl:ENST00000449264.3, Ensembl:ENSP00000398698.2, Ensembl:ENSG00000232810.4, GeneID:7124, KEGG:hsa:7124, MANE-Select:ENST00000449264.3, CTD:7124, DisGeNET:7124, GeneCards:TNF, HGNC:11892, HPA:ENSG00000232810, MalaCards:TNF, MIM:191160, MIM:607507, MIM:610424, MIM:611162, neXtProt:NX_P01375, OpenTargets:ENSG00000232810, Orphanet:40050, PharmGKB:PA435, VEuPathDB:HostDB:ENSG00000232810, eggNOG:ENOG502S4K8, GeneTree:ENSGT01060000248544, HOGENOM:CLU_070352_3_1_1, InParanoid:P01375, OMA:GATMLFC, OrthoDB:1124938at2759, PhylomeDB:P01375, TreeFam:TF332169, PathwayCommons:P01375, Reactome:R-HSA-381340, Reactome:R-HSA-5357786, Reactome:R-HSA-5357905, Reactome:R-HSA-5357956, Reactome:R-HSA-5626978, Reactome:R-HSA-5668541, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, Reactome:R-HSA-75893, SignaLink:P01375, SIGNOR:P01375, BioGRID-ORCS:7124, ChiTaRS:TNF, EvolutionaryTrace:P01375, GeneWiki:Tumor_necrosis_factor-alpha, GenomeRNAi:7124, Pharos:P01375, PRO:PR:P01375, Proteomes:UP000005640, RNAct:P01375, Bgee:ENSG00000232810, ExpressionAtlas:P01375, Genevisible:P01375, GO:0009986, GO:0009897, GO:0005576, GO:0005615, GO:0005887, GO:0016020, GO:0045121, GO:0043025, GO:0001891, GO:0005886, GO:0032991, GO:0055037, GO:0005125, GO:0042802, GO:0002020, GO:0000976, GO:0005164, GO:0006919, GO:0002526, GO:0048143, GO:0019722, GO:0071230, GO:1904646, GO:0071346, GO:0071316, GO:0071407, GO:0071300, GO:0097237, GO:0002439, GO:0007623, GO:0050890, GO:0030866, GO:0050830, GO:0050966, GO:0048566, GO:0072577, GO:0060664, GO:0030198, GO:0097191, GO:0008625, GO:0006006, GO:0006959, GO:0007249, GO:0006954, GO:0008630, GO:0007254, GO:0002523, GO:0050901, GO:0031663, GO:0097421, GO:0000165, GO:0001774, GO:0097527, GO:0010693, GO:1900222, GO:2001234, GO:1903347, GO:0120190, GO:0043537, GO:0061048, GO:0043154, GO:0002719, GO:0045892, GO:0001937, GO:2001240, GO:0045599, GO:0010629, GO:0046325, GO:0010459, GO:0032715, GO:0002037, GO:0050995, GO:0010888, GO:1903799, GO:0045930, GO:0031642, GO:0045662, GO:0035509, GO:0050768, GO:0045668, GO:0090324, GO:0043242, GO:2000272, GO:0003085, GO:0000122, GO:0061044, GO:0045071, GO:0030316, GO:0045760, GO:1902004, GO:0043065, GO:2000334, GO:0060559, GO:0070886, GO:0045785, GO:2000343, GO:0032722, GO:0002876, GO:0043280, GO:2001272, GO:0001819, GO:1900017, GO:2000573, GO:0051091, GO:0045893, GO:0070374, GO:2001238, GO:0031622, GO:0032724, GO:0010628, GO:0060252, GO:0051798, GO:2000347, GO:0034116, GO:0002925, GO:0043123, GO:1903721, GO:0050729, GO:0032729, GO:0032731, GO:0032741, GO:0150129, GO:0032755, GO:0032757, GO:0046330, GO:0043507, GO:1904999, GO:1904996, GO:0043406, GO:0043410, GO:0051044, GO:1902895, GO:0045840, GO:0071677, GO:0150078, GO:0043525, GO:1902565, GO:0051092, GO:1901224, GO:0045429, GO:0051000, GO:0051173, GO:0045672, GO:1903223, GO:0033138, GO:0050766, GO:0014068, GO:0071803, GO:0043068, GO:0045732, GO:0045860, GO:0051897, GO:2000010, GO:1903078, GO:0001934, GO:0051222, GO:0031334, GO:0043243, GO:0046427, GO:0048661, GO:1901671, GO:0050806, GO:1901647, GO:0045944, GO:0045994, GO:0042531, GO:1904707, GO:0060557, GO:0043491, GO:0072659, GO:0060693, GO:2000351, GO:1903140, GO:0045598, GO:0043122, GO:0002637, GO:0050796, GO:2000377, GO:0050807, GO:0051966, GO:0006357, GO:1905242, GO:0014823, GO:0045471, GO:0009750, GO:0051384, GO:1990268, GO:0140460, GO:0001666, GO:0036005, GO:0031667, GO:1901554, GO:0009314, GO:0009651, GO:0009615, GO:0009410, GO:0030730, GO:0003009, GO:0034138, GO:0033209, GO:0010573, GO:0042311, CDD:cd00184, Gene3D:2.60.120.40, InterPro:IPR006053, InterPro:IPR002959, InterPro:IPR021184, InterPro:IPR006052, InterPro:IPR008983, PANTHER:PTHR11471:SF23, Pfam:PF00229, PRINTS:PR01234, PRINTS:PR01235, SMART:SM00207, SUPFAM:SSF49842, PROSITE:PS00251, PROSITE:PS50049 |
| Sequence |
mstesmirdvelaeealpkktggpqgsrrclflslfsflivagattlfcllhfgvigpqreefprdlslisplaqavrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial |
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