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| Record Information |
| Record ID |
24 |
| Pubmed ID |
28451790 |
| SNP |
|
| Gene ID |
6351 |
| Protein ID |
P13236 |
| Vaccine Adverse Events |
usual type vulvar intraepithelial neoplasia |
| Vaccine |
HPV16 E7 DNA vaccine |
| Gene Name |
CCL4 |
| Official Symbol |
C-C motif chemokine ligand 4 [Homo sapiens (human)] |
| Aliases |
ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 |
| Other Designations |
C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; MIP-1-beta(1-69); PAT 744; SIS-gamma; T-cell activation protein 2; chemokine (C-C motif) ligand 4; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; secreted protein G-26; small inducible cytokine A4 (homologous to mouse Mip-1b) |
| Chromosome |
17 |
| Location |
17q12 |
| Annotation |
Chromosome 17 NC_000017.11 (36103827..36105614) |
| MIM |
182284 |
| DNA Sequence |
>NC_000017.11:36103827-36105614 Homo sapiens chromosome 17, GRCh38.p14 Primary Assembly
AGCACAGGACACAGCTGGGTTCTGAAGCTTCTGAGTTCTGCAGCCTCACCTCTGAGAAAACCTCTTTTCC
ACCAATACCATGAAGCTCTGCGTGACTGTCCTGTCTCTCCTCATGCTAGTAGCTGCCTTCTGCTCTCCAG
CGCTCTCAGCACCAAGTAAGTCTACTTTTGCAGCTGCTATTTCGAGTCAAGGTGTAGGCAGAGTCCTTTT
TTCTAGTCATGGCTGGCAAACAGTGGGATCTGGGGATGGGACAAAAGGCAGCTAGGAAGATTGCCATGTA
GTCTGCTGCTAAATGTAGAGTCTAGTAGATATTCAATAACATTCAAGTTCCTATTTTCTTAAGAATTAGC
AACCAGCAGAGGAAAACGATGGGCTGGAAGTCAGACTGTTGAATTGGCTCTGCCTTTAATTATTTGTTCA
AGCAAGCCCCTGTCCCTCTCTGTGCCTTGGTTTCCCCATCTGTCATATGAAGGGAGTGCGATGTGTTCTG
AGACTGAATCCAGTTCCAATCTTCTAGATTTCTTTCTCGTTCTTCTCTGAAGATCCACTATTCAAAATAA
GACTCCTGCTCATGTTAGGTGGGAATGGATATTTGGGGTTCTGGTAGCTCCACAGGGATGCTCAATGAAG
ATACAAAATTAGAAGTCAAAATAAACAGCTCCCACGGGCAGTGTTGATCTCACCCTGGCCTTTCCTTTCA
GTGGGCTCAGACCCTCCCACCGCCTGCTGCTTTTCTTACACCGCGAGGAAGCTTCCTCGCAACTTTGTGG
TAGATTACTATGAGACCAGCAGCCTCTGCTCCCAGCCAGCTGTGGTGTGAGTATCAACCCCTGGGCTGCC
CTGGGAGGCAAGGGTGAGGGCTGGATTTTAAAAGAGGGCCTGTTTTGGGGAGGGGGTGATTGAGCATTGG
GGAGGCAGCTCCCAGGGCTGAAGCCTTCCCTGAGAGCAGTGAGGACACAGGTCATGAACTCACTTTTCAA
GTGCTGAAGGCGGCAGAGTGGGAGCCGAGAGAGAAGGGGGTTGCTGGGGAGGAAGTTATTCAGAGGACAG
GGAAGCAGGGGAAGGCAGACAGGTCCCATGAGATATGGACCGATTCCTTAAACCGTGCTAGAAAGACATG
TGGAAAAGTCACTGCCAGGCTGGCAGGGAATGGGGAGATCTATTCATATTGATTGCAATGCCCCTTGGTT
CCTAATCTGGGCAACTCCTGGGGCCCACAGCTAAATCCAGTGGGTGGAAGTTACAGGGAGTCTGCTTCCA
GTGCTGCTCCAGGAAGGATCCCATCCACCAGAGCTGCCCCACATGGACCATGGTCAGGCAGAGGAAGATG
CAAAGGATAAAGCCAGATGACCTCAAAGGTCTCATGAGATTCTAATCTGTCCGCTCCTTGTTCTACAGAT
TCCAAACCAAAAGAAGCAAGCAAGTCTGTGCTGATCCCAGTGAATCCTGGGTCCAGGAGTACGTGTATGA
CCTGGAACTGAACTGAGCTGCTCAGAGACAGGAAGTCTTCAGGGAAGGTCACCTGAGCCCGGATGCTTCT
CCATGAGACACATCTCCTCCATACTCAGGACTCCTCTCCGCAGTTCCTGTCCCTTCTCTTAATTTAATCT
TTTTTATGTGCCGTGTTATTGTATTAGGTGTCATTTCCATTATTTATATTAGTTTAGCCAAAGGATAAGT
GTCCCCTATGGGGATGGTCCACTGTCACTGTTTCTCTGCTGTTGCAAATACATGGATAACACATTTGATT
CTGTGTGTTTTCATAATAAAACTTTAAAATAAAATGCA
|
| Protein Name |
CCL4_HUMAN |
| Length |
92 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-JAN-1990 |
| Definition |
RecName: Full=C-C motif chemokine 4; AltName: Full=G-26 T-lymphocyte-secreted protein; AltName: Full=HC21; AltName: Full=Lymphocyte activation gene 1 protein; Short=LAG-1; AltName: Full=MIP-1-beta(1-69); AltName: Full=Macrophage inflammatory protein 1-beta; Short=MIP-1-beta; AltName: Full=PAT 744; AltName: Full=Protein H400; AltName: Full=SIS-gamma; AltName: Full=Small-inducible cytokine A4; AltName: Full=T-cell activation protein 2; Short=ACT-2; Contains: RecName: Full=MIP-1-beta(3-69); Flags: Precursor |
| Primary Accession |
P13236 |
| Accession Version |
P13236.1 |
| Other SeqIDs |
sp|P13236.1|CCL4_HUMAN,gi|127080 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Dec 6, 2005 this sequence version replaced gi:74739044, gi:7428599, gi:120635.; [FUNCTION] Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.; [SUBUNIT] Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). {ECO:0000269|PubMed:12070155}.; [INTERACTION] P13236; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-2873970, EBI-11343438; P13236; P13236: CCL4; NbExp=3; IntAct=EBI-2873970, EBI-2873970; P13236; P34972: CNR2; NbExp=3; IntAct=EBI-2873970, EBI-2835940; P13236; P48165: GJA8; NbExp=3; IntAct=EBI-2873970, EBI-17458373; P13236; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-2873970, EBI-13345167; P13236; Q9NZD1: GPRC5D; NbExp=3; IntAct=EBI-2873970, EBI-13067820; P13236; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-2873970, EBI-10317612; P13236; Q6IN84: MRM1; NbExp=3; IntAct=EBI-2873970, EBI-5454865; P13236; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-2873970, EBI-18159983; P13236; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-2873970, EBI-17595455; P13236; Q9BRI3: SLC30A2; NbExp=8; IntAct=EBI-2873970, EBI-8644112; P13236; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-2873970, EBI-10262251; P13236; P30825: SLC7A1; NbExp=3; IntAct=EBI-2873970, EBI-4289564; P13236; Q9NYW4: TAS2R5; NbExp=3; IntAct=EBI-2873970, EBI-17933167; P13236; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-2873970, EBI-6268651; P13236; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-2873970, EBI-8638294; P13236; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-2873970, EBI-11724423; P13236; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-2873970, EBI-2548832; P13236; Q86WB7-2: UNC93A; NbExp=3; IntAct=EBI-2873970, EBI-13356252; PRO_0000005165; P51681: CCR5; NbExp=2; IntAct=EBI-6625160, EBI-489374.; [SUBCELLULAR LOCATION] Secreted.; [INDUCTION] By mitogens.; [PTM] N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.; [SIMILARITY] Belongs to the intercrine beta (chemokine CC) family. {ECO:0000305}.; [CAUTION] Was originally thought to be a ligand for CCR8. {ECO:0000305|PubMed:9521068}.; [WEB RESOURCE] Name=Wikipedia; Note=Macrophage inflammatory protein entry; URL='https://en.wikipedia.org/wiki/Macrophage_Inflammatory_Protein'. |
| Source Db |
UniProtKB: locus CCL4_HUMAN, accession P13236;; class: standard.; extra accessions:P22617,Q13704,Q3SXL8,Q6FGI8; created: Jan 1, 1990.; sequence updated: Jan 1, 1990.; annotation updated: Oct 12, 2022.; xrefs: J04130.1, AAA51576.1, M25316.1, AAA57256.1, M23502.1, AAA36656.1, X53683.1, CAA37723.1, X53682.2, CAA37722.2, X16166.1, CAA34291.1, M69203.1, AAB00790.1, M69201.1, M69202.1, AY766446.1, AAX07305.1, AY766459.1, AAX07292.1, CR542119.1, CAG46916.1, AC003976.1, BC104226.1, AAI04227.1, BC104227.1, AAI04228.1, BC107433.1, AAI07434.1, M57503.1, AAA36752.1, A31767, NP_002975.1, NP_996890.1, 1HUM_A, 1HUM_B, 1HUN_A, 1HUN_B, 1JE4_A, 2FFK_B, 2FIN_B, 2X6L_A, 2X6L_B, 2X6L_C, 2X6L_D, 2X6L_E, 3TN2_A, 4RAL_D, 4RAL_E; xrefs (non-sequence databases): CCDS:CCDS11308.1, PDBsum:1HUM, PDBsum:1HUN, PDBsum:1JE4, PDBsum:2FFK, PDBsum:2FIN, PDBsum:2X6L, PDBsum:3TN2, PDBsum:4RAL, AlphaFoldDB:P13236, SMR:P13236, BioGRID:112254, BioGRID:132664, DIP:DIP-5840N, IntAct:P13236, MINT:P13236, STRING:9606.ENSP00000482259, BindingDB:P13236, BioMuta:CCL4, DMDM:127080, MassIVE:P13236, PaxDb:P13236, PeptideAtlas:P13236, Antibodypedia:72629, DNASU:6351, Ensembl:ENST00000615863.2, Ensembl:ENSP00000482259.1, Ensembl:ENSG00000275302.2, Ensembl:ENST00000617322.4, Ensembl:ENSP00000480345.1, Ensembl:ENSG00000275824.4, Ensembl:ENST00000621600.4, Ensembl:ENSP00000478708.1, Ensembl:ENSG00000277943.4, GeneID:388372, GeneID:6351, KEGG:hsa:388372, KEGG:hsa:6351, MANE-Select:ENST00000615863.2, UCSC:uc002hkw.3, CTD:388372, CTD:6351, DisGeNET:388372, DisGeNET:6351, GeneCards:CCL4, HGNC:10630, HPA:ENSG00000275302, MIM:182284, neXtProt:NX_P13236, OpenTargets:ENSG00000275302, VEuPathDB:HostDB:ENSG00000275302, eggNOG:ENOG502S8M4, GeneTree:ENSGT01050000244851, HOGENOM:CLU_141716_4_0_1, InParanoid:P13236, OMA:SGPKKCC, OrthoDB:1575018at2759, PhylomeDB:P13236, TreeFam:TF334888, PathwayCommons:P13236, Reactome:R-HSA-380108, Reactome:R-HSA-418594, Reactome:R-HSA-6783783, SignaLink:P13236, SIGNOR:P13236, BioGRID-ORCS:388372, BioGRID-ORCS:6351, ChiTaRS:CCL4, EvolutionaryTrace:P13236, GeneWiki:CCL4, Pharos:P13236, PRO:PR:P13236, Proteomes:UP000005640, RNAct:P13236, Bgee:ENSG00000275302, ExpressionAtlas:P13236, Genevisible:P13236, GO:0005576, GO:0005615, GO:0048020, GO:0031726, GO:0031730, GO:0008009, GO:0005125, GO:0042802, GO:0007155, GO:0007267, GO:0071346, GO:0071347, GO:0071356, GO:0070098, GO:0048245, GO:0007163, GO:0007186, GO:0006955, GO:0006954, GO:0048247, GO:0002548, GO:0043922, GO:0030593, GO:0051928, GO:0050850, GO:0070374, GO:0043547, GO:2000503, GO:0009636, GO:0009615, GO:0007165, InterPro:IPR039809, InterPro:IPR000827, InterPro:IPR001811, InterPro:IPR036048, PANTHER:PTHR12015, Pfam:PF00048, SMART:SM00199, SUPFAM:SSF54117, PROSITE:PS00472 |
| Sequence |
mklcvtvlsllmlvaafcspalsapmgsdpptaccfsytarklprnfvvdyyetsslcsqpavvfqtkrskqvcadpseswvqeyvydleln |
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