VAEAG: Vaccine Adverse Events Associate with Gene

Record Information
Record ID	238
Pubmed ID	34484238
SNP
Gene ID	59272
Protein ID	Q9BYF1
Vaccine Adverse Events	vaccineinduced immune thrombotic thrombocytopenia
Vaccine	COVID-19 Vaccine
Gene Name	ACE2
Official Symbol	angiotensin converting enzyme 2 [Homo sapiens (human)]
Aliases	ACEH
Other Designations	angiotensin-converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme homolog; angiotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A
Chromosome	X
Location	Xp22.2
Annotation	Chromosome X NC_000023.11 (15518197..15607211, complement)
MIM	300335
DNA Sequence	>NC_000023.11:15518197-15607211 Homo sapiens chromosome X, GRCh38.p14 Primary Assembly TTTCATTGTTGTGTCTTTTCCTAGCCAGTAAGCCCATAAATAGTCACCAAAAAAAAAAAAAGAAAAAATG GGTGCATGCGGGAGATGTCCTTAAGATGGCATCACACATAACAGGCAGCTGTTATTAGCTGTCATTCTTT CCTTACCATCAACATGGCCAAGACTGCTTTGTGGAAGTATCCTGGTGTTGAAATGAAACTCTATAGGACA AAAGCAGAAAACAACATAATTCTTTCCCTCCATTATCCCTTCAAAGCTATTCAGTGGGCTTTCTTCCCTG CTTCCAAATAAAGTCTTTGCCAAATTCCATAGTTTTGCAGTCATTCTCAAATGATAAAAATGTCCCCATT ACTTGTAATCATAAGAACAGCCTCTGAATTGTTCCATCCAATGTTATTATCACATGACTGCAAACATCAT TCCAAGTTAAACATCTGTCACCTAGCTTGGGCCTGCATCACCTGGCAGCATGCTTTTGGGGAGGGATTTT GGGGGGGCTGAGATTCATGGCCCTTTCAGAGTTAGTTCCAAGGAAGATGAGGTCTAATTAAAAAAAGACA CACATAGCTGTTTCTATCATGATTTGGTGGTGGTGGTATCGGAGTGAGTTTTCCAGCACTGATTCTTTAT CTCATGGGAGACTTTTAGGAATTTCCTACTGAAGGGCAGATCCATATGTAGTTTTATGACAGGGGAGAGA TCTTGATCCTCAGTTCTTGGATTTTCAGCCCTCAATCTTTCAAGATGGCTGTCAGCCAACTTTTTCCCAA GAGTGGAGTTGGCCTATAAGAAAACAAACAAAACCTTGATTGCTCTGGTTAATTAAGCTGTATGTAGCTC TCTCTCGAAGTACAGGCTACTGCTGTCTTTTTGCTCTACTCTCTTGGGTTCATAGCCACAGCCTTCTGTT TTTAGGGTTCCCAGGCAGGTGTGAGCCTCCTCAAATGCCAGGATACACAAAAAATGGCTTCCCATTGGTT CTCTGGAAGTTCACCTGAAAGCAAGGGGACATCTCCGCCCATCTATTGGATCTATGGTGTCTTGGGTACT TATTTTCAGCTACACACATTCGCACACACTTCTCTCTTTCTAAGTAAAAGCCACATAATTTTCATGAATC AACATGAAAGACAAAAATAATCCATTATTGTAGTAGACTGAATAATGTCCCCCAAATTTCATATCCATGT AGAACCTCAGAATGTGACCTTATTGGAACTAGGATCTTTGCAGATGTAATTAGTTAAAGATCAAGATGAA ATCACACGAAAGATGAGAGTGGGCCATAAATCCAATGACTAGTAAGATGAGAGGACACAGAGAGATACAC AGAGGAGAAGGCCATGTGAAGACCTAGGAAGAGATTGGAGTTATGTTACCACAGGCCAAGGAACACCTGT TTCTTAGTCCATTTGTGCTCTACTAAGGAATACCTGAGGCTGGGTAATTGATAAAGAAAAGAGGTTTATT TAGCTCACCGTTCTGCAGGCTGTACAAGTAGCATAGCACTGGCATCGGCATCTGATGAGGGCCTTAGGCT GCTTCCACTCATGGCAGAAGGGAAGGGGAGCTAGTGTGTGCAGAAATTGTATGGTGAGAGAGAAGAAACA AGAGAGAGGGAAGGGAGATAGCAGGCTCTTTTCAACAACCAGCTCTCATGGGAAATCATAGAGTGAGAAC TCATTCACTACCATGAGAATGGCACTAGGCCATTAATGAGGGATTCGCCCCTATGACCCAAATACCTCCC ATTAAGCTCTACCTCCAACACTGGAGATCACACATCAACATAAAATTTGGAGGGGTCGAATATCCAAACC ATAGCAACTTGGAACCACCAGAAGCTGGAAGAGGCAAGGAAAGATTTTATCCTAGAGGCTTCAGAATAAG TATGGCAATGCTGAAATGTTGATTTTGACTTCTAGCCTCTAGAACTGTGAAACAATAAATTTTTGTGGTT CTAATCCACCAAACTTGTAGCAATTTGTCATGGTAGCCCTAGGAAACAATTATAATCGTTAGGAGTTTTA CTTTGTTATTAGCAACATTGCTGTTTGGGTTTGAAAATATGTTTCAGTCCTGAAGCTTGAAAAGTATGGC CCTCTAAAACACCTAGGAGAAACGCCCAGATTAGGCAAATCTATAGAAACAAAGGGTGATCAGTGGTTGC CTGGGACCAGAGTAGGGATGAGAATTGACTGCAAATAGGTATGAAGGATCTTATTGGAGTGATGGGAAGA CTGGGCTGTGGTGATAGTTATACAAGTTGATAAATTTACAAAAGTCACTGAATTCTGCACTTTAAAAAGG ATGAACTACCAATAAAGTTTGTTTTGACAAGTCTAAGAGCAGAAGATAATTAAGAGCCAGAAACCATTGC ATCTAGTCTCCAGCAGGGAACTTTTTGGCCAATATATTGAAAATTATCAGCTAGGCAAATCAGTGGCTAA GGGTTCATAAGCCTGTTTTGATTATAAGCTTCCCAAATGAACCAGGGATCAGAGGGTATCATGTAAAGTA TGTTTTTCTTTGTTTTGTTTTTTATCAGAGTATTCAGTAGAGGGCTTATTTTCTGAATGGAGGAAATAAA AATCAGCTCTCTAGTTGTTCTGTTCAAAGAGATTTCCTTAAATGATTTCCATTTAAGGAACTTCCTAGTG CATTTTTCTTTGGACATAACCCACTTCACAGCTCATAAATAACACTGTCCTGCATAATTAAAATTTCCAG AATGTCAAAGCCTTAACTCCAAGTAAATGAAATTTCTGAAAAACTAAAATATAGCATGAAAAAAATATTA AATGCATCTCTTTCTGTCACACACGCACACACAGACACACACACACATATTGTGAATTTTTAACTGAAAT ATAACATTAACATAGAAAAGCACACAAATCCTAAGTGTTCAGCTTGATGAATTTTCACAAACTGAACAAT TCTGTATAATCCACCCTCAGATAAAGAAACACAACATCACAGAACCCCAGGGACACCCTGATGTTCCCTT TCAGTCACTACTACCCTCCAAAAGTAGTTGCTAACCTGATTTATAACATCATAGATTGTTTGCCTGATTT TGACTTTTATATGACTGGAATTATAAAGTGTGTAGTCATTTATTGTGTGTCTTCTTTTCTTCAATTTGTG AGATTCGCTTATTTTTTTAGTATGTGATTATATTTACCGTCATCATTGTATAGAATTCAGTTGTGTGAAT ATACAACTGTTTTGGTTTCTTATTACTGTTCTAACAAATTACTACACAAATTTAGTGGCTTAAAGCAACA TACATTTATTCTCTTATAGTTTGGAAGATCATATGTCTAAAATGGGTCTGCACAGCTGTGTTTCCTCTGG AAGCTTTAGGGAAGATTCTGTTTCCTTGCATTTTCCAGTTCCTAAGGGGTACTTACATTTATTGGTTCCT GGCTCCTTCCCCTGTCTGCAGAACCAGAAGGTTGCAGGACCTCTACTCTCTAACCTCTGCTTCCATCCTC ACAGCTCTCTAATCTCTGACCACCTTATCTCCCTTTTATAAAGGCCATTTTGATTACATCAGGCCCACCC CCACAAAATCCAGAATAGTTGCCCCATCTCGAAATCCTTAATTACAATCTGCAAAGTCTCTTTTACCACG TAAGGTATTCACAGGTTCTGGGAATTAGGACATGAACATATTCGGGAGACCATTTTTCAGCCTTCAACAA CCACAACATGTTTATTATTTTATCCTCTTGATGGGCATGTAGGCAGTTTCTAGTTTTTATCTAATTAAAA TAATTCTGCTATGAACATTCTTTTACAGGTCTTTTGGTTTCCCTGTTGTGTATATATACGTAAAATTTAT GAGTCATAGGGTATGACCAGATGCACATCCAGATTTACTAGATTCTGCAAACAAATTTCCAATGTTGTTG TACCACTTCATACTCCAACCAGCAAAATATGAGTTCCAGTTGCTCCATATCCTTGCTCATACCTTTCTTC TTTCCTTGCCTCTTTCCTTCCTCCCTTCCTCCCTCCCTTCCTCCCTCCCTTCTCTCCTTCCTTTCTCTCT CTTTCAAGAGCTGATATACTTAATTGTCAGTTCCCGGTACCTGAATCTGTGCCTCACTGTGATGTATTAA AATTTCTTCCCCTCCAAAGCTGAAGATACCTCGGGCAGTTCCTGTTCTCAAAATGGATGCACCATCTTCA AGTACCACTCTAGCCCAATATGACAACGAATCAAAGAAAAACTATGGCTCCCAGCCACCATCTTCAAGTA CCAGTCTAGCGCAATATGACAGCAACTCAAAGAAAATCTATGGCTCCCAGCCAAACTTCAACATGCAGTA TATTCCAAGGGAAGACTTCCCTGACTGGTGGCAAGTAAGAAAACTGAAAAGGTAATCCCCAGCTTTCAGA CGGGCTGCCCAGCATGTAGAGTAAACACTACCCCGGCTGCCCTGGACCTCAGCCTCAAAGCTGTTGATCC AGGTCTTAGGCTGTCCTCTCAGAAAATGTTCAGTGCTTGAGCCAGAAGTCTGGGGAAGCAGTGGCCCCAC TGGGGCTGAGAAGCATAGATTTTCCATTTAGATTATCCAATCTAATGATCTCAGTAATGCCTGATCATTG TATTCCCTTCCCTTTCTCCTCCTTCTCCCCCCAAATATCTCCACATTCCAGAATACAGAATCTTTAAAAA TCTATCCTTTATATGAAAGAGCTTAGGATGGGCTTACTTTTGTAATGTGCTTCAGTATCACTAGCCAAAT GGCAAATAGCATTTCAAGCAAGGCCATGGCTTGCCTTCTTGGAATGTACAACCTCACCTCTCCTGACCTG ATTAGTCTTCTCACAGTTTTTAGCCTAAAGATTCTATCTAAAGCCAGAATTGAAAATTCCTTGAAGGCAA CATGTAAATTGTGTATGTATGTATCTCTTGGTATGGCACTGAATTTGCCCTACACTTGATGCCCAATAAA TGTTGAATTGAATTGCAAGATGACCATATGGAAAGGGTCAAGTGACTCCCCTTCCTTATTTCCTGTCTCA GACCTCCTTCCTATCATGTTGTCTACTCTCTGCCATCTTCTCACTCAGTTATCAGCATCCCTGCAGGGAA GTCATGTCTGCCTTTCCCCACAATGGATACAGAGCATCTCTCTGACTCACCATGTATCTCTTTTCTTAGT TATTTTTCCCATGTCCTTTTATTCCTTTGTTCTTTCCATCTTCATCATTTTTGCCTAAAGCCAATTACTG AAAGTTTCAATAATACAGGGCCATATGGAATTTGAAATAATGTAAGTGTGTTCTTCTTGATTTTTTTTCA GTATAATAAGCCATGGTCCCTTTCATTCCAAAGTGGAGCTAGAATCCTAGTGTATTAATCTATACCTGGT GCCCAAGGTATGGGGTTACATTTGTGCGCCTGCAGCCCACCATTCTTGTGGAAGGAGAGGATCAGTAAAC CCAGTTGCAAGGAGAGTGAAAGTCATGTTAATTGTGTTCCAGGTCCCCTTCCTGACAGAAACTCCAGTGA TTCATTGAGAGAGGTGTGAGGTGAAGCTGACTGCCCTGTTTTCAAATAACCAGGAGGAACTGTCGATTCA CATGGGGTTGCTGCCATTATTGAGTTTTTGACACTCCTTTAGATTTGCACCTCCTTAGGTTTAGTCCCAA CTGTGGATTTTCCCTAGAACTTCAGGAAGCTAGTTATTTTAACAAAGGATTGATTGATCACCTCTTAGCA TGAGCAGCATTGCATCTGCAAGTAAATTATAATAATTGCTAAAAGGTCTTCATGGAGCTTGACTTTTTAA AGTGCAGCCATGATTCTTATCTCATATATGGGATAATACTTTTTATCAACTTTCTGTCATTCTTACAATC TTCCCTGAGCTTCTTTTTAATCTACTTTCTGTTTAGTAAGATAATCTATGCCCCCATTAAATCATTCAAA TATTACAGAATATTCCATTTACATTCCCCTAAAATGTTTTCTATGCACATGTGGCCATGTGCATACAAAA GCAAGTAAGTTCTCACGATACAGTCTTTGTCATTTGTTCTTTTCACTTGACATCTTCAGCATTTTTCCTA TTTGAATACATGAGGATACACCTGACTTTTAAAATTTCATTTTCATTTAATTTTGGTGAAATATACATAA CATAAAGTTTACCATCTTAATTATTTTTGAGCATACAGTTCAGTAGTGTTAAGTACATTTACATTGTTGT GCAAATTGCCTGATTATTTTTAATGTCTGTAAGTACCAGTTGTATAGATACTAGGTAAACCTAAGTGATG CACTATTGATGGACATTCTCTAAGTGTTTTTAGAAACAACAAGGCTAAATAAAAGCTATTCTAGTGGGCA AGGCTCTTTGGGAAGGTGGAGAGAGAGGCATTTTAGAGTTTAAGGGCTTTATCTAGGCATTCCTTGAAAT AGAGCCAGGGGAGCATTTCCTTGCTAAGGAAACTTGTTTCTATGAACTGTGGTTTTGAAAAAAGTCTGGA CTATGAAGGCAAACAGGAAATAGGTTCCACATTCCAGATAAAACAGCCTTTAGACTTTGAGAGGTAGGCA CTTCTTCATGCTCTGCTTAATACCCCAAATAAAAGAGATAAAATGATCTATGGCAGAGGATGATGAAAAT CCTCCTTATCCATCTGTGTCCAGAAGGAGTAAAAAGATCAGCATTTTCAAGAATTTTAATTGTAGTCACA ATAGCTAAGAGGAAAATAAGTTATTTTAAAATATATAAGTGACAGAATGCTTGCATATATATAAGAAAAT CAGGGCAAATCCAGTCAAGATGATTTATTAATCTAGATTTTCCATTGTTTAAGATAATTATGAGCCATTA TTAACAATTTTCTTTTGTTTAGAAGTGTTGCCAGACTACTGCTTTTATTGGAATGCCTGAAAGAACCAAA ATGTGAAAGTAACTCATTAGCTTAAATTTCCCAAACAAGTGAAATGTGTGGGTCAAAATGTCAAATAAAG CTAAAACATATCTGAACAAAATTACTTTTGTCATTTAAAATTTATAAGTAGACATATGTTTATAAACTTA TAAAATGTCTCTTTTTTGCAGTAGCAGCAGCAGTGAAGATGTTGCAAGCAGTAACCAAAAAGAAAGAAAT GTGAATCACACCACCTCAAAGATTTCATGGTAAATCAAATTCAGATATCTCCTACATCCAGAATATGCTT CCATTTTCAGGAAAACTAACCAAACTTGCAATAATTTTGCAGCTAGGCTTTCTACTTAAGGTAAATATAA ACCAAAAAAGTCTATGTAGTTTGCCTCTCTGAACCCTGAATGGATGGCTTTTGGGTTCTAGTTTTTCTTG AACTGACTATTCCTAGCCAGCATCCATGACATACACCAGTAGTAGCACCAACATTAGTATACCTGACCCA GGCATCTCTAGCAGGAAGAAAAGCAACCTAGAGTTGAATAACTCTTCCATAAGAATAGCTATATACACAA CCCAATTTTTTTTTAACTTGATACTACAGCCATCTCTGAAGGAGTCTTCATCTATTTCGTGAGCCCACTC TTTGGAAAAAGTCAAAGAAATATAAGTTCTTCTGGGGGCCTCCTGGGGATCTCCTGTATCAAAGAACCAT TCTTTCATTAAAACTTGGCATAAGCCCAACTTTTGAGTGACTCTCTCTTTACTGTTGCTGTGTTGATACT TTGCCAGGTGCAGAAGGAGAAACCTAACAATCTAAATGTTATTTAGGTGGATAAAATCAGGGTGGGATTT GATATTGCATGGCTACGCACTTGGATTATTTCTTGGTGCTTTTCTGCACTCACGTTTTTCTCAACTCTTC TTAAGGGAATTCCCTGAGTCAAGTTCATCTGAAGAAGAGGAAAACCTGGATGATTATGAGTGAGTATTGA AAGTCTTCTGGGTTCTTCTAAAATTAGACATAGATACTTCTACTCTCTTCCTCAAAGACATTAAAACAGA TGGCTGAGACCGTCTCAGGAGGCTGTATTTACATGGGTAAACTCACGTAATGTTCTGGGTCATTTATCTA GATGACAGGTGACAATGAGCTGGGTTGTTACCAACGAAAATATTTTCCCCAAAACTGGATTATCTAAATT GGATGCAAATACTTATTGGATTTATCGTATGTCCAGCGTCACCTTCATTTCACTTTACCTTTGTAGATGT AGCATATAATGTTTCTGCTCATTATTTCTTTCCTGGAGACCTCTAATTAAGGTGATGTTTGAAAGCTCTT ATTAACATTGAGTAATATTTTTGGAGAAGTTATTAATGATGCAGTAATTTTACAGGGTAGCACAAATGAG ACCTTGAACATGGCAATATTTATGTCGACAGATCTCTATTCTTAGGATGACCTTGTCATTTTTTTTTTTT TTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCATTGCAA CCTCCACCTCCTAGGTTCAAGCAATTCTCCTACCTCAGCCTCCCGAGTAGCTAAGATTACAGGCGCCTGC CACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTTGCCAGGCTGGTCTTG AACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCT CACCCAGCCAACCTTTTCATTTAACATCAAAATTGGGATACTTTAGAAAGAGAAAAAGTGCACTATTAAA AATTATACCCGTTAATAATAACTTAATTATACATTTTAAAATAACTTAAAGAGTATAATTAATTGTTTGT AACTCAAAGGATAAATGCTTGAAGGGATGGATACCCCATAATCCATGATGTGATTATTATGCATTGCATG TCTGTATCAAAATATTTCATGTACCCCATAAATATATATACCTGCTATGGTGAGCCGAGATGGCGCCACT GCACTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAACAACACAAA CACACACACACACACACACAAATATATATATATATATATATATATATATATATATATACACACACACACA CACACATATATATATACCTGCTATGTACTCACAAAAATTAAAATAAAAATTACACCTGGACATTTGACAT AAACTGGACTTCTGGGCAAATAAGAACGTGTGGTCACCCCAACTATACTGAGAAGGTTGGCCTAAGTGGC TATTAAGGTTCTTTCCAAAATCTAAGGGTCTATCATTCTACAAATAGGGACAAATAATTGTCTCCTAGAT GTAAAGATTAGTGTTAAGAAGAGGTGGGAATAATAGAGCATATTGCATTTCTCAGACACTTGATACCAAA TGGCACAGAATTCACTTGAACACTAGGATTATGCATATTTCCAGTTCTGTTTTTGTACAAGTGTTGTATT ATTGATTTATTGATTACATGTGAAACGAGAGCTTTTACAAAGTACATGCTACTGTTTTCACTCCTCCTCT CATCTCTAACCCAGCCTGGTCCTAGCCATACCTGTTGCATTGGGGAAGATGTGCTGTACCCTCCACATCT TTGTGGCATGGTCTCTTTATCACCTTCTAGCTCTCTTTCGGCTTTACTTTCTTCCCTAACATCTATTCTC AGGAAAGCATTGATGGAATAATTCATACTAAGACATAAAAGACTGAGAATGACCAACGCATGGTCATTTC CAAAGATAATTGCACTTTAATGAAACACAAAGACTTAAACCAATGGGAGTGAACCTCTAATTGTGGATTG TACTCTTTAGCATTTAAATAAATTAGAAGTCTTTCCCTGATTGGGTAAGCCCAGATATGACCATTTAAAC AGTCTCTATTCCCATCTTTTCTGAATGCAAGTGGTGTGTGAGAGACAGACATTGAGGAAATTATCAGGGA AGACTTGTCCTCTTCAAAATCAAAAAGATACCAAAAGGAGCTCGGGATTATAGGGCTATAGGATCTGGGA CTCAGTCACCTCACATTGTGCTTAATGCTCCCAGCTTCCTATTCTATCAGTGTCATGGGAGTTTTTGTTT TATGGCCATAACTTCATGAGCAATTCCAGTCAATTCCATTAAAGACAGAAGCACTAAGCCCTGAGATTTA GATAGAAAATCGTGTGTTAAGACTAGGCCTGGCCAGGTACAGTGGCACATGCCTATAATCCCAGCACTTT CAGAGGCTGAGCTAGGCAGATCTCTTGAGCTCAGAAGTTTGAGACCAGCCGGGGCAACATGACAAAACCT CATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTTGCCCATTCCTGTAGTCCCAACTACTTGGGAGG CTGAGGTGGGAGGATCACTTGAGCCCGGGAGGTCGAGGCTGTAGTGAGCCGAGATCATACCACTGCACTC CAGCCTATGTGACAGAGTGAGACCCTGTCAAAAAACAAAACAAACAAAAAAAAACCTTAGGCCTAGGACT CTGCTGCTCTGTCATTGAATACTGAAATATTATTTAAAACAATAAGAGGCAGGCCTCAGCAAAATTATGA CACAGGCAACGTTTGTATGTGTGTGGGAGGTATAATGTATAGGGTACATAGGTTATATCACCTTGCCTCT CCAGGCCTCTCTCCTGATTCTTGATTTTCTTCCTTCTATTCCCCTGTAGGTATATATCCTGTATCACAGC CCCTGAAGGGCCTTTTGATTAGCTAGTATTACCTTAAAATGTTGACTAATAAGAAAAACGATCAGTTAAA ATTTCAAGTGTTAGTTATACAGTATCCATAATGGTAGAGTTAAAAGAGACTTTCAAACTTATCAAGATCA ACCCTCTCCCTAGTTTTACAGGTAGGGAAGTCCAAGGTCAAACAAGGCCAAGTGGCTTGTTCAAAGTCAT ACAATTACACATAGGGAAGTTATGCCTAGAACCCAGACCTCCAAGCTGGGTGACCTAAGGCTCTTTCTAT TTTATTGAGCTGTCCACCAGCTGACATCCCTTCCCAAAACTCATACAGAGATTATACAAAGAATCACTTC CCATCCATTCCTGCCAAGTTCTGAGATACCTTCTACATTGAATTTCTCCTATAACTCCTCCCTTCTACCC TCACCCCCCTCTTGTACTTATTTCCTCTGCAGATGTTATCTTCTAGCCAGTGGGTCCTCCCACTCACCCA AACCCATGCTACATCCCACCTCATGCCCTGCTTTTACTCATTTCCTAAGTAGGACATTCTGTCTAAAGCC CAAAGGCCACAGACATTATTGCCCTCACATGAGAAACAGCTCTTGGCCTGTTGAGCTCCACATATAAAGT AAAAGCATTTGATGTGAAAATAGATGTTATAATCAGATTATTACAAGGAAATTATATGATTGGAAGACAA GAGCTTTCATCCTTGGCAGCCCTGACTTTCCTCTTGGAATATTCTTCATAGGTCTAATCTCTAGCCCTTA CTCAAAATGGTAAAATGTAGGAAAACTTAGAAGTCACCTAGAAGAAAACCAAAGATTCCTAAATGCCAGC CCATTTAAAAATTAGATGTGCAGACTCCACCCCAACATCAGAATTTAGTAGTGGGGACTTAAGCATTTGT ATTTCTGAAAAGCTCCTCAAATCATTCTCTGGAGCAGTTAGGCTTGGAAACCCCTGAGGTAAGCCAATGC CTCATTTTACAGATTAGAAAGTTGAGTGTCAAGCTATACAATCTAAAACTTATTGATTCTCACATATAAT TTTTTTCCTTTTGCAGCTGGTTTGCTGGTAACATCTCCAGATCACAATCTGAACAGTTACTCAGACAAAA GGTAAATAGTCTTGTCTTTAAAACAGCCTCACAGAATCTCTTTGCATTTTGGGGTCCAGAGGTTGATGCA TTTCTCATAGAAACCTTCCTGCTAATTATATAGTCAAGTCATTGTAGTGTTGCTTGTCCAGTCTGTGGGT TGCCCGACTCTTCATGTCTAGCCACTACTTCTGTGTCCATTATGTATTGCTGCATAATAAACCACTCCTA AATTGGGTGGCTTGAAACAGTGGGATTTATGATATCTCATGATTCTGTGAGTCAGCTGGGCCAGCAGTTC TTAGGCAAGTTTTGCTTAGGGGCACTCCTGTGGCTGCATTTGGGTCGTGGATTGACTGGGGGCTTGGGTT TAGCTGAGGCAGTCAACTGGAGTTCCACAGTTCTTCCCCAAGCAGTCTCTCCATGTGCCTCACTTGGGCC TCCTCACAGCATGGTGATCTCAAGGCAGTAGTTGAAGAGGACGAGCCCCACAGTGCAAGCACTTTTCGAG TCTCTGCTTTTGTTGTGTTTGCTAAGGTCCTATTGGTCATAGCAAGTCACATGGCTCAGCCCAGAGTCAG TATGGGAGGGGACTGCTCACAGCATGAATAAGAGAGATGATTTATCGGAGGCCGTCAATGTAGCCATTAA CCTCAGCTCTGTCACTGCTCGTTAGCACCTAGACCAGAGTATAGCAGATGTGATACAGAACATGTTTATC TGACTTTATTACTAATTGATATGGAATGCCAGTAGCAAACTCTTTTGATTTCTAAAAATGACACTTTGAT ATAGTTTAACCTGATAAAAACACTAAACATTACACTTATTTCTTTGAGGGGTGCTAGTGAGAATGTAATG ACTTCATTTGGCGTTTTGTCACATTCATAGTTTATAATCTGCTCTTTCTGAACTTTGATCTGCTTAGAAT TAGCACAAATCATTGAGAAAGACAACTTGAGTATAGAACTTTATCAACTGATTTATTCTTGATCTTTGGT TTTCTAAAACCTTCCAAAGGCATGATACGGTGATACACGGTTCTAAATTGTATTTCTTAAAGATGAAAAC ATTAGGCTTGCATAAGCACAACACCGAGAAAAGTAAGTGATAGGGTTAAATATTAATTGGAGAGGAAGAG TTCATACACATACACATACACATAGAGCAGATCTATAAAGAGATTGAGTGAGAAACCTGTGCCTTTTGTG ATATATAAAGTCAATCTAAAAGATTTGTTTTCCAACTACCTACCATGCAAAATCATTTTCAAGAATGATG AAAATATTTTCTATTCCTTCTATATTTTCCTTCCTTTTCAGGGAAAAGAAGGAGCATTTATGGTTAGAAA TTCGAGCCAAGTGGGAATGTACACAGTGTCCTTATTTAGTAAGGCTGTGAAGTAAGTATGATACGGATTA ATTTCTTTTCTCTTTCTGCGTATATTCTTTGAATATGCTGGTCACAATCACATTTTGGGATAAGACATCA TCTTTAAACTCTGGAATTTTAAATCAAAGTATTTCTATTGAATGTGACCATTTGTAGTTGCCTCCACCAC TCTCACCCCACTGCCCCACCATCCTTGCCCCACTACTTTCAAGAGGCCATTCTCTGGCTAATCCTCTCCT GCCCCACTCCAGGCAGTAACAGAGTGCCCAGAGCACAGCATGCCTCAGTAAATGTTTATTAAGAGACTCT CGGGTGATTCCCTTTCATTCAGGTCTAAGCCTGGAAAGAAAAAAAATAGCAATGGAGCGTCTATACTCTC AGCCCTAGCCACCTGCTGAGCAAAGATGCCTACTCCAGTGTCCAGTTCTTAGTAAGCCCTTCCACTGGGT GCAGAGTTAGCAGAAGGTTGACTCAGTGCTGCTGTGTTCTCTACACAGCTTCCTTCCAGGGCTCTGTCCT CTTTGTGTGACTAAAAGTTCTTGTTTGAAGCCAAACTTCTAGATCCAAATCCTGGCTCTACTATTTCAAT AGGGCTTTGTGACATTGAGCAAGTTTCTCAGCCTCTGTGCCTCAACTTCTTCATTTGAAAGGGGAACATA ATGATTGTTACGTTCTATGAGTGGGGTGAGTTAATTAATATATTATATCCAGAACAGTGCCTGACACATA GTAAGCACTTAATAAACTAATAGTACTTACTATTATTGTTGTTGTTGTTGCTGGGGAAGGGTAGTTCTAC CTGCTCCACTCCCTGTACCCTAACACTTGGGCATAAAAGACACCCCACAGTCATCTCATGCAAATCATCA TCAAAATCCTTCTCCAGAGTTTTACAAGCCACTTTCTTATTGGTAGTTAGCTCTTTTTTTTTCCTTCTAA TCGTCCTCCAAAGCAAATGGGAAAGCTGTTTTTATTTATACCATATTGCAGATGAGAGGATTGAGGTTCA AAAAGAGCTTATAAAGACCTACCTGGAGCTACTAAGTGACTAATTTGAAGCTGGGCTTCCAATAGCCAAG TCATGTTTCTTTATCTACACCTCTGTGTTTACACTGAACCCCCAGTGTTTTGGAATGAGAATCTGGTCAA ATATTGATTCGGATCTTCTTTTAAATTTCTATGTGTGCAACTCTTTTTTAGCAGCTAGATTGAATGATCG TCTGCCTTGGTGCCTTCCCCATGTGCCCTACCCCACAGTGCATATATGTATATTTATAATAATTAAGTAA TAAAAACGTTATTTTATTTTGAAATTTTTTACAGAGTGCCTACCTACACTTGAGATAATAGGATGTACCT GAATTGTCCCACAGCACTTTCCAATGCCAGAATCCATGTCCCCAGTGTATCTCATATATTATTTTGCACA TGGTAACACCTGGATGCTGGCTAAAGCCAACCCAGTAAGAATCAGGAGAAGACTTTGTTGACTATCAAAA GTTTTGTGGCCTTCTGGCCCTGCAGTTTCAGCCAAACCTGGTATCAGATGTCCTTGTAGTTGAGTTTCTT GACTACAGATTCATTTTTTAAGGTAGCCAGGTAGATAAATCAGCAAATAGATAAAGAATCAAATGAATAC AGAAGCCCTCTTTTATGAAACCTCATCAATGGCCTTGAGTGAATTGTATGCTGACACCAAAAGCTGATTA AACATTTGCAGCAAAGAGAAGAACCATTTCTCCTTTTGTACTTGCAATTTTTACTCGGTTGATGTTACAG CAACAATTTTTTAATTTTTTAGCTTTTATTTTAAGTTGATTGGTACATGTGACAGGTTTGTTATATAGGT AAACTCTTGTCATGTGGCTTTCTTGTAGAGATTATTTCATCACCCAACTACTAAGCCTAGTGTTCAATAG TTATTTTTTCTGCTCTTCTCCCTCCTCCCACCCTCCACCCTCAAGTAAGCCTCAGTGTCTACTATTTTCC TCTATGTGTCCATGTGTTGTCATCATTTATCTCCCACTTACAAGTAAAAATATGTGGTATCTGGTTTTCT GTTCCTGTGTTAGTTTGCTATACAGCAACAATTTATTAACTGTTTCTTATATGCCAGGCATAACCATATA GGTAGCTAGCAAGTGATAGAACTAAACTCAAAGCCTGGTTCTTGACCACTATGTCATTGTCTACAATCTA AGACAGGTGTATTATTCCTGATTAGCTTAAATCAACGTGCATCAATTCAGCATTATTGTATAAAAGCAGA GGAAAAGAAAAAAGTGTTTTATGTGGAGAAGGTACAAGTTCACATGAGGAATTAAAGGACATCCTCACCT ACTTCATTCTGCATGCCCCAAAAGAGCCTCCTCCCATGTTTTGGGGTGAGGATACCCAACAGCCTAATCA CCTTTACCTCTCTCATTTCCACCTCCATTATTATCCTATAAGATAATTTATGTTCAGAATAATGATCCTG AAGAACTACAAGCCTCTCTCGATCATCAAAGAAAGATTCCAGTTTTATACACTTACTAAGGGAGGAGAAG CCTGGAAAGTTGGAATTTTACTGTACATGAAATCTATATGTGCACCAAAAGATACATTGAGTTCAGAGAA GAACTCTCTTCCATAATTACTTTTATAGTTACACCAGATTTCAAGACTGAGAAAAACACCAGATGCCAAG CCTGAGAAAACCTCCCTGACTTCCCTCTCCAAAATTTGCAAATGCACCTAAAATAATTATTTAACCCTTG CTTAATCAAGCTTTATTGTTTATTTTAAATGTTCTAACATTCTTTCTGTTACTAGTGATAAAAAAGGAAC TGTCAAACATTACCACGTGCATACAAATGCTGAGAACAAATTATACCTGGCAGAAAACTACTGTTTTGAT TCCATTCCAAAGCTTATTCATTATCATCAACACAATTCAGCAGGTAACTTATTTTAGTTTTTCTTTTATG GGCCCTTGTTGTAAAACAGCAATTTTCCTGGATACTACTGATCCTCCTAATATTCTTAATTATATAGGGA ACCATGAAAGTAGGAAAAAATCCTCTCAAGTCTTTTGCCTATCATAATTTTTAGCTTACATTCCCAGGAA TATAACATGATTCTCTCCTTAATGCCAGAAAGAATGAAATTGAGTAAACTGGGTGACTTAGAAAGAGAAA TTCTCTTTATAAAAATATTCGTAGGGTTTTTCTGTGTATAGAAGCAAGAGGATTATAAATTTAAAATATT ATAGAAATATATACATATCGTTGGATCATGGACCAGTTGTCTATTATGACAGGGTTTTTTGCATGCTGCC ACTAGCACTTACTAATCATTACATATATAAATAGAAATTATATATTATGTATATACATTACATTTTTACA GAGATGAGATCATTCTACACATATTGCTCAGCTTGCTTTCTTTACTCAACATGTCTTAGAAGTCTTTCCA CGCAAACACAAAGAGCTTACTTTGGTCTATTTAACAGCTGTGTAGAATTCTATCATAGTTACCCCATAAT TTATTCACCTAGCCCTCTGTTGATTAGCAGTTGGATCATGTCCAGTATTTTCACATTATAATGGATGTTT CAGTGCACAATTCTGCATGCATAGCTCTGTCCATCTATATGAGGGGTTCTATAGCCAAATCCCTAGAAAT GGAATTTCTGAGACAAAGGCTAAGAATACTTAAAATGTACAGATTGCCAACTGCTTTTCAGAAATGTACA ATCCTACTAACAACATTTTCTTTCATCCTCACCAACACTGGGTGCTATTAGTCTTCTAAATTTTTGCCTA ATCAACTGGTGGAAATACATCTAGAAATACCCTCTGTTTTCTAGAATAGTGCCACTTAAGAGCAGTGGCT GGATGAATTTCCAACAGTGAGTAAAAATAAGCCATAAGCTCAGCACTTAATTTGTGTTACTTTATATGAC TTGATTGCATGCATGTAGGTGAATTGACCTCACTTCTGGCTTTCATTTTGGCTCTTACTGATGTTTTTCC TTTGCCCCAATTTCCTCAATTGTTTATTTTAACCTGTAGTACCTCAGAAGTACCTTTTGTAAAAGGTATT GCACAAAGAGATGCACAGGAAACTTCACAGGATATCAGAAGGAAATATTAAGATGTTTATTTATATTTGG ATTTTTATCTCATTCTCTTACATTTTCTGTTTGTGAGTTTATTTTTATAATTCACACCAAATATATATTT TATAGAAATGTACTAATTTTTACATTTTAATTAATTAATTTAGTTGATTAAAGGTAAAGGATTTTAAAAG TTTGGAGACCACTCATATAAAAACCAGACAAATATATAGAAAAAGGAAGGAGGGGAAAAGTACATGTGTG ATAGATAGGTCCCTTGACTTGGAGAGCATTCCACATTTAAAGCAAAAAACATATATACATATATTTTAAT GGGTTCTTTCAAGCCACTATTAAATTTTATAATTACTTTAACCCAGTTTTACCATAACTAAATATAAACA ATTAAAATGGCTTGACCACTTAATGAAACTTAGTAATAGGTTCAGTTTTTAAAAATTCAGATGGCTTATT ATTTTTACCCTTCTGTATTGTTTGAATTTTTTGTCAAATGTATGTGCTGTGTGTATACATATTTTAAGCA TAAGATTGTAAAGAGATAGCAAAAAAGAAGGGGGAGAATTTTAAAAGATTACATCATGCAATTAATTTCT ATGGGATTTTTAAAAATCACATACAGTGTTTTATTCATTTAATTTTCGCTTTGCATTAAGCTAATTAGTC AAGTTAAGCACAACTACAACTGAATGGATTCTCTCTCTGCATTACAACATTCTGAACTCTTTGCTTTTTC AGCCACTTTGGAGAGAGACTAGTTGTGAACCAATGTTACATAATGTGATGGGATATGATATAATGATGTG ATGATATGATGCTGATTCCATTGCAGGCATGATCACACGGCTCCGCCACCCTGTGTCAACAAAGGCCAAC AAGGTCCCCGACTCTGTGTCCCTGGGAAATGGTATGGATACATACTTGGGTTCTTAAACTCCATTTTCCA TCATTTTTTATTTAAATATATGGTTAATTTACTGGCAAAAAAAAAAAAAAAGGAGGAAAGACAGGAAGGA GGCCTCTGTTCAGATTGTATCAGGAAGGATTTTCTTTAAAAAAAAAAAAAATCTGTCCTCTCAACCTAAA TCTGTAAGCTTCTAGAATCACCAAGAAGATCATCAATTTGTTTTCTTATCAGACCCCATTATTAGCCTCC AGCACACCATTGTCTGTCCTATCTTTTTCCTGGATTTTGTGCCCACTGAGCAGAGCCAGTATTCAACCTT GTGTGTTAGGACGATCACATCCACTGCGATCACAGTTTAATTTTTTTATTAAAAAAATCTGACAATGTTT TACCAATCTAAGGACATCGAGTACATTTTGATGCTAAGCCTCTCCAAGATGCCTCTGATTGGCAAATTGT TTTTACTCTGAGCCTTCTTGTTAAATAACTGTAGCTACTTCAAGAATAGTGTTACCCTGGTGCCATTATC ACGTAGCCACAAGACCACATCACTAAGGGTTTTTTTTTTTAACTTATCAACTTAAAATAAAAAGTCTTGT TTATATTGTCACTGTGAAACTCCCATTGGAGAAGAAATCACTTGGGAAGCTGTTAGCCCCAAAGCTTTCT ATGCTCGTCCTAAAGAATGTCCGTCTTGCCTTGTTAGGAATCTGGGAACTGAAAAGAGAAGAGATTACCT TGTTGAAGGAGCTGGGAAGTGGCCAGTTTGGAGTGGTCCAGCTGGGCAAGTGGAAGGGGCAGTATGATGT TGCTGTTAAGATGATCAAGGAGGGCTCCATGTCAGAAGATGAATTCTTTCAGGAGGCCCAGACTATGATG TAAGTTTTTCCCAAGGAATGGCTGTTTAGCCCTCATCATGGGAGGGCATTAGCACTAATAGGCCTGCTGT TAACTTTGCAAGGCCTAGAGCAAAAGTCCACATACTGTATCATAGACATAAATATTTAGAAGTTATAAAT TGAACTAACAGACTATTAAATCAAATCAGTCTTATGCTCCTACTTTGACAAATATACCTTCATAACAACC TGAAAGGCCATATTCAAATTGAGAATTCCCAAGACTCTACAAAGAAACCAGCCTCTGGCCTGTGGTCTTC CAAACTCCACCCCTCCTGCTTCTCCCCTCATACCCAACTCCGTCCTGCACTATAAGGGGCCTCAGTAGTT ATGTACAGACACAGCATTCAGTACACACAAGCTCCCTCTTTGTCTCCCGCAAACAATTATCTAGTGGCTA ATGATCTTGGCTAGGGGTAGTGTGCTTTACCCTTAAGCGGACAGACTCCTTAAGGAAGAGTCAGCACAGG TCCTGAAAGAGGCCTCAGGACTATATGGTTGGGTGATTTCAGAGTCCTGGTGCTCTAAGGGTGGCAGAGA AAGGGACATATAGGGTCGGAGTAGGCATGTCTCCTTGGCCCTGTGGCCTCCTTGCCCTGTGGGGAGGTGC ATGGTGGGATGAAGAACAGAGTGGGGCTACCACCCAGAACTAATGCAGTACTGAAAATTAATGCTCTACC AACAATATCCTTTTCCTTCTTGGTACCTTCAATACAGTCTAATACTCTTCCTAATGTGTCTCAGCTCCCA GCACAACAGCCTTCAATTATTGGCAATACATATGTGTTCTCTTTCCCTCTGTGTCTTCTCTCTCTCTCTC TCTTCCCCCTCTCTCTCTTTCTCTCTCCCTCTCTCTCCCTCTTCCTCTCTCTCCTTCTCTCTCTCTCTCC CTCTCTCTCCCTCTCTCAGTTGTATATAATTCTCCCTCTTCTTGTCAACATAGTAAATCAGACTTTGTAG AGTGACCACCATTCAGGTTTGCTGAGGTCTGGGAGGTTTTAGCACTGAAAGTCCTGTGTCCTAGGAAACC TCCCAGCCCCAGGCAAACCAGGACAGTTGGTCACTCTACTTTTAGAGAATCAATCAGTATGGTATGAAAA ATGATGTTATAGTAGGTCTCTGGTCAAAAATAGTTGAAATAAAAAAATTCCTAGCCTGCTAGAGATTGAG AGCACTTTTTAAATTTTTACTTAAACAGTTATACTGTACAGTGTTTACAGGCATTTCTCTAAGCACTTTA CAAATATTAACTCACTTAATCCCCATAAGAAACCTATGAGGGTTGTACCATCGTTATCTTAGATTTACAG GAAACCGAAGCACAGAAATGTTGAATAACTTGTCCAGAGTCGGCAAGCTAGTAAAAGTCGAAAAGCAGAG ATACAAACCCAGGCAGACATTCTAGGGTCCATTTCTTTAGTTATTCTTTTATGAAGACCAAAGGAATTAG GAAAGTCAGAACAATCACTTTTACCATAATTGCAAAATTATTTGGAAGCAGAGATGCTATGTGAATATAG GCCTTTGGCCCTAGCTGGCTTCATGGGCATATGAGATCTGCACAGTTGCAAGGGCCTAGAAGTACCTAGT ACCTAGAAGGTACCTAGAAGGGCACAGTACCTAGAAGGGCCCTGTGCTTGGTTTAATGCTCTGCTGTTGT CATCTTGAAGTAATACTTCGTGATTTTTAAACAAGGATTCCTGCATTTTCATTTTGCATTGGTGCCTGCA ATTATGTAACTGGTTCTGCCTTCAGTGATTGGACTGTCATAAAACTGGGAAGGGGGCCCCTGATATTCTC CTCTTGTAGGACAGGAAAATCTGGCAGAAACTTTCTGCCAGATTTTTCTCATGGTTACAGGCTCATGATG TAACCTCTGTGTCTTGGTGTAACTTTAAAACATATTTTTGCCATTACCAAGCTGGTATCCATAAAAAAAT CACAAGAAGTCATTTAAAAACATCACCTAATCATAAAGAAAAACGTCAAACTGTGCCACAATGGGAAAAA GTCTAATCCCAAATGTAGGGGTCAAGCTGAAGCCTATCATGTGGGGAATATCAGTTAATATGGCGCCCTC ACCTTGAGCCACCTGGGCAGTGACTGAATTTGTTCAAAGAATATTTCTTTATTGGGTGATGGACCTTTGT GCCATCACAAGCCTTCCCTCTGAAGGGAGCAGTGTTGAGTACCATGCAGGTCTCCAAAACTGCTAAAAGA TGAATACTCCCAAGCTCATCAACTTGAGTGACATGATAAGCATTGTCCCTATAGTTAAACTAAGAAGGAA GAAAATAACTAAAAATTTAATAAATTCTTATTAAAATATTTAAAACTTCACATGTTAAATTTAGATTTCT TTACACATTTGAACATTACAGAATAATCCTGTAAATTGTTAAAATTAGATTAATCATATAAGAACAAGTT AATGAGCTTGTAAAAACTGAGTGTCCCTTCTCAAAAGAAGACATTTATGCGGACAACAAACATATGAAAA AAAGCTCATCATCACTTGTCATTAGAGAAATGCAAATCAAAACGACAGTGAGATACCATTTCACGCCATT TAGAATGGCAATCATTAAAAAGCCAGGAAACAACAGATGCTGGAGAGGATGTGGAGAGAAATAGGAACGC TTTTACACTGTTGGTGGGAGTGTAAATTATTTCAACCACTGTGGAAGACAGTGTGGTGATTCCTCAAGGA TCTAGAACCAGAAATATCATTTGACCCAGCAATCCCAGTACTGGGTATATATTCAAAGGATTATAAATCA TTCTACTATAAAGACACATGCACACATATGTGTATTGCAGCACTATTCACAATAGCAAAGACTTGGAACC AACTCAAATGCCCATCAATGTTAGACTGGATAAAGAAAATGTGGCACATATACACCATGGAATACTATGC AGCCATAAAAAAGAATGAGTTCATGTCCTTTGCAAGGACATGGATGAAGCTGGAAACCATCATTCTCAGC AAACTAACACAGGAACAGAAAACCGAACACCGCATGTTCTCACTCATAAGTGGAAGTTGAACAATGAGAA CACATGGACACAGGGAGGGGAACATCACACACTGGGGCTTGTTGGGGGGTGGGGGATAGGGGAAAGATAG CATTAGGAGAAATACCTAATGAAGATGACGGGTGCAGCAAACCACCATGGCACATGTATATATATGTAAC AAACCTGCACGTTCTGCACATGTATCCCAGAACTCAAAGTATAATAAAAAAAAAAATAAAATTTAAAAAT CAACTTCTGCGTGGCAACAAAACAAAATAAAAACCCTATGCAAACTAAAAGACAAATGATAAACTGAGCA AAATTATTTGTAATTCATATTATGGACAAAAGACTAATCTCCCCAAAAAGGCTAATACCTCCAAACTCAT TAACAACTACACTACTGCACTGTTTGTTTGTACAATGGATCACTCAGAGTCAGCTCAGAATCTAAGAGTA AAGTACATGTCAATCCAAAAATGTGTCCAAATTCACTGAAATACAATGTAGAACAGAAAAGAAAGAGTAA TTGGAGTTGCTAAGTACTTTCAAAAGGCTTTATGCTTAACCGTGAAGACAGTAAAGAGAGTAAAGCAGCA GTTCGGGAGCCTGTCTGGAGAAGTAAAGGTGATATGGCAGCACACTGCTAGAGACTCCGCTAGACATTTA GCTTAACCTATGCATCTCACAAATGGAAAAAAAAAAAAAAAGATAGGTGAGAAAAGATATCATGAGAAAG GTAATTAAGGTAGAAGAATCACACTTTACAAGAAGGTTTGCTTGATTTCTTTTAAGCTCTAGGCTAGTAC AAAATTTAAGATTGATATTACTTAAATTAATAAGAAACACTAAAGGACTCTTCAATTCGCAAGATTAAAC ACTTCCATCTGGAACATCTGATTACTAAATAATAGCCCATAGCTACATTACGCTCCATTTTCTTCTACTT AACTTTATCATTTTAAAAAGGGTGCTGGGAAGAGGTACGGTAAAACCATCTGCCATAATAAAATGAAAAT TATCTCATTAAAAAAAAATCTGAGTGTCCATGCCATCATGACCTACCAGAAGTGCTACATCATATGGTTA GTATTTTATAAATTTGTTATTCAAAAATAATGAAAACAATAATGTAAAATAATTTTTTAAAAAAGAAAAA AAATCAAACCTCATCTGACTTCATTTAGCCTACATTCTTCGTATTCTAATATACTTTTTTAGAATGAAAT ATTTAGATGTGAAAGTTAATAAAAGAGAAATGATTGTTCTTAGGGTGTGGCTTCCTCTAAATAAGTCATG GACGTTCCCAGGATGCCATGAGACTCAACAGGGTTTCCAGTGCAACAGACCATTGCTACCCTGATTCTCT GTAGGAAAGTTGAATACAGCATTCACAAACTGCTAAATTGCTGCTGAAGTCACCAATGTCTGATATGAGG CAGAAATTTTTTTTGCCTCCAAAGATAATTGTGCTTGAAATATAAGATCCTAAACTTTTCCCTCTCTTTC TCTGTTCAAGTGAAAGAGGGTGGGGGTGGGAATTAAAACAAACAGAAATCTGAGAGCAACTCTTTTTCAG TACATGTAGAAAATGGAGTGTGGAGCATTGAACTTTGAAAATCTGTTATTTCCAGGAAACTCAGCCATCC CAAGCTGGTTAAATTCTATGGAGTGTGTTCAAAGGAATACCCCATATACATAGTGACTGAATATATAAGC AATGGCTGCTTGCTGAATTACCTGAGGAGTCACGGAAAAGGACTTGAACCTTCCCAGCTCTTAGAAATGT GCTACGATGTCTGTGAAGGCATGGCCTTCTTGGAGAGTCACCAATTCATACACCGGGACTTGGTAAGCAA AGCCATTGGAATTTCAAAGAAAAGAAAGCAGTCCACGGCTCCCACTTCTGGAGATGGGGTCACTGGTAGG GAAGGCAAGAAGGGCACCATCACTTCTACTTTGCTCACTTGTGACTTGTTTAAGCAAATGACATTTTTAC AAAAATCAATGTAAAAATATTTGAAGTATGGAAAGAACAGTGAGAATAAAATAAGCTGTTAAGGTCTACA TAGCTGTGTTGTGGCAAGAAGGAGAACAGATGGAAAGGAAAGACTTCTGCCAATTTAGTGTCTCTCAAAA CCATTAAACCCAAATTGACCTTCATTTCAGGAAGGGCTTAGTGCTAAAGCAGCCATTTGATACAATAACT GAACATGAAAAAAAAAAAAGGAAATAGAATTTGTGTGTCTTTGGATCAGAATGAGAGTGGGGAATGCTGT GTTTGGTATTCACTGGGATTTATCTTTAGAGATTTTCTTGCGCTCAACAGTAGACCTGCATTCACACTAG GCCAGTGTGTTCCCTAAGTCACAGGTGCAGCGTTTATGCCTTCAAAGCATCTGTGAATGCACGGTATCTG GTGGTGGAAAGGGAGATTCTAGAAATTTCTCATCTTTCCTTGATAAGCTAAGGTTCTGTGTTTAAAGTGT AATACCTTTTCATGTTGTTTGACAAGGATGGATGCTTGGTTGAAAGTACTCATGGGAGAACATTTTTATT TTGAAAAATTGAAAATTGCAAAGGAAAAAAAAGACAACTTTAGAGCACTTGGGGGTTGTGCTAGGTAATC TTAGATTTTGCTGAGAATTCTACTCAAAAGGAGGAAAATGTCAGGAGATTCTTGGTCACTTTCACTACTT GGTGATTTTGTTTTTCCTTTAAAGGCTGCTCGTAACTGCTTGGTGGACAGAGATCTCTGTGTGAAAGTAT CTGACTTTGGAATGACAAGGTAAGCCAATTCCGAAAGGGCAACCAGTGAAAGGGGGATTTCCATTCACAT TTGAACACCATCATAATTGAAGGCTTTGTGGGGATATAGAAGGTGCTCTGAATTGGGGGCTTAGAAACCT AAGTCCCTCCCATGGGATTGTTCTTCAGAAATTATCTGACGTCACTTTTAGTTCTTTCAACAATCTGATA CTTTCTAAACTTCTAAATAAATTCCATGAAAGATCCTAAATTTAAATACAACATGTTACAGCCACATTAT TGGATTGTTTTACTTTCTTTTAAATTTTTTTATTTTTAATTTTTGTGGGTACATAGTAGGTATACATATT TATGGGGTACATGTGATGTTTTGATACAGGCATGCAATGTGAAATAATCGCATCATGGAGAATGGGGTAT CCATCCCCTCAAGCATTTTGGAGTACTACTCAGCCATTTAAAAAGAATGGATAAATATTTATAATTTTTT AACTCAATCAAGGATCTGCTAGCTCTTTTTGTCTGTCATTAAAAAAAAAACCTGATGTTCAAATGGGTAG AGCATTCACACTAGGAAAATTTTTGTTGTCACATCATTAGATTTTCTGCATCACAAAGTAAGGCATAAAA CTAGACTCTGAGATTCTCTTGATGGGCATTCTACCACCACTTAATGATGTGGAACAATTATTTTGATTAC GATCGTTTTTTTAAAGTCTTCTTTTACCTTAATCCTGTATCCTAATACTATTTAAGCCTCAGAGCAAATT TTCATAGTTTTGCAAAGAAAACGAAGACATACACATTAACCTTTCTATTCAACATTTATTGAGTGCCTAC TGAATACCTCAGTCCTGCAGGAGATACTGATATGAATAGGATAGTCCCTGCTCTCAAAATGACCACAGTT TAGTCTAGAGGGCAAGTAGATATCCCTGACATTGAGACAAAATATAACTATAAAGTTGTGCTGACTCAAT ATGTAATTCTGAAGGTGAATAATGCAGTTTAAAAGAGATCTGAAGAGTTGACCAAGGCCAGGTTAATATT TAGCAAACATTGCCCTAAAATGCCATAGGAGGATCTGTTTTTTTAATGTCTTCTCCAAAATTCAGTGTTA GGGGATGCTTTTTGACCCTTGTGGCACATACCGTGGAAGCTATGGTAATTCCTCTGGGAGCCCTAAATAT TGGCAAGATGTCCTTTTAGCTGTGTACTAGCTACCGTCACTCCAACCACCATACACTGAGTCCCCTACAC TGACCCTCCAAACATGTAGCTTTCTCAAGAGCAAGAAAAAAAAAATCTGCTGACAGGTTCTTAAAGCAGG GAGAAGCTCCCAGGTCAAGGGAACTGATCCCCACCTTTACTCTAAAAGCAAGAATATTGGCTGTTATGCC AGCATCCAGGGAACATGCTTTCACGTTCTCTGTAGCTTTGGAAAAGGGAGACTTTTCCAAAAAAAGATCC AAAGAAAAAAGAGATCTTGCTCTGAGTAAGAGATCCTGGAAGCCATGTACCAGCCCTGTTGGTTATGAAG CTCTGTGGCCACATCAATTAGATGCCTGTGACTTCATTTGCTCCTACTAGCTTGAAGGAAGGTTTAAGCC ATGAGCATCCCCAAACCAGGAGTGCCAGGGTAGTGTCTGGGTATCTGGTAGTGTCTGGGGAGCTGAGGGG TTCTGGGGAGAAAAGTATGGAATGTACTGTATGTAATCCTATGAAAGTGTAGTTTATTAATATTATTGTT AATATTTAGAAGGATGATCTTCCCAGCCAGCTATTTTAAATTACAGTGAGATCTCTAAAACATTTGGTGT GTAAATTATATCCAAAATTCCAATTGCCATAACTCCTGTTGTTCTATTTTCTCTAATTAAGAGTCATTAT GTGTTTGTTTTTGTTGTGGTTTTTGTGGGCAAATATATGATGTTCTCTTTTATTAATACTATAAATAATA TGTACTTATTATAAGAAAAATAGCATTAGTGTAGAAAGTAAAAAGTAGAATTGTTAGCAGCAGTGAATCC GTAAAGGTCTGCAGCAACTCAATTCTTGCCTCCTCAAAGGAAAGGATTCATCTGAGGGGCATAAGGCAGA GAGAGAGACTGAGGCAAGTTTTTGAGCAGGAGTGAGAGTTTATTAAAAAGTTTTAGAGCAGGAAGGAAAG GAAGTAAAGCACACTTGGAAGAGGGCCAAGAGGGCAACTTGAGAGATCCAACTGCCCTACTTGGCCCTTG ACTTAGGGTTTCATACATTGGCATAATTCCAAAGTTTGCATCTTTTCTCCCCTGATTCTTCCCTTGGGGT GGGCTGTCTGCATGAGCAGTAGCCTGCCAGCACTTGGGAGGGGCCGCACGCACAGTGTGTTTACTTAGGT TGTGCGCATGCTCATTTGAGGCATTTTTCTTTTACCAGTCGAGTATTCTTAGAGGAAGGTCATATACCAG TTAAACTCCATTATTTTGCCTCTTATTGCGCATGTTTGACCCCAGTTGCCCAACTCCTGAGATCATATCA GGAAGCTGTTGATCATCAGCTTCAAGTATTTTCTATCTATTGGGAGACTGCCGTTCCCTGGCACCAGCTG CGACCAATTATTATTTTAGAGAGACGGTTAACAACTGCCTGACTATTACCTGACGGTCACCTAATATTCC TGGGTTGGGGGTGGGGGATCTCTCCTGCCCTGCTCATGTCTGCCTAGCTACCTATTCTGACAGAATCTGT CCCTCATTTTCAGTGCTAGGAGTAACCACTGCTCAGATGTTTGGTGGGTATCCTTTCAGACCTCATTCTT AAGTGTATCCAATCATATACACAAATATGCACATTTACTACTTGTTCCCACACACAAAAAATGGAATCAC ATTATACACACTTTCTTTTGCACATAACCATATACCATGAGCACCTTTTTATTTTGGTGAAGAGTTATCT CATTTTTGAATGGCTATGTGCTATTCTATTGTGTGAGTGTGCCATAATATATTTAATTACTCCTCAACAT TGGGAACATTGAGGTTGCTTTCATTTTATCATTATTACAAACAAAGAGTTTAGTGAACATTCTTCAACAT GTATTTTGGTCTTGATATCTCCATAGGATATTTTTGTTCATCATTATTCATAACAGCAGAAGATTAGTAG CAATTTACCTGGTTAAATAAATTATGTTTAATTCCTTCCATAAGAAGAAATAATAAGAGGGAATGGTATT CAGCCACTAAACATGATGCTGCAGTAGAAATGTAACCGTATGGGGAAATGCTCATGATATACCATTAAAG GAAAAATAAAAGCAAATCTCAATATAACAGAAACCCTATTTTGTTCAACTTATATATGTGGGAAATAAGA TCAGAAAGTACAAAGAAAAATGTATTTTGAGTGATAGAATTACAGGTTATCTTTAGGGTGGGTTTCTGAG TAATTTTATCTTTACTTTTTTGTGTTTTTCTATATTTACCAAACATTTTGCATTGAGGTTTTGCTGTATT CAGTTAGATATTATCTTTTAAATGCTTACAAACCATAAGCAGCCTCCAGCTAAGCCCACACATTGAAAGG AAACAAAAGTTCCAGAAAACTGAGGCAATCGACTGAGACTCTGGGTGGCTTCCGTGTCCTTCATCAGCCT GTACCACCACGGCTTAAGGTCTGTGTTGATGTGTTTTCCCTGGCAGGTATGTTCTTGATGACCAGTATGT CAGTTCAGTCGGAACAAAGTTTCCAGTCAAGTGGTCAGCTCCAGAGGTGTTTCATTACTTCAAATACAGC AGCAAGTCAGACGTATGGGCATTTGGTAAGGATGTGGCCACATACGACCTGGCCCTGTTTCATAAGCTTA CTTCCACAACAGGAAACCACAAGAGTAGCAATGTCCATTTTAAAAGGGCCCTTGAACACTTACGAAGTTA CACATATAGCCTGAGAGAAGCAAGCTGTTGAAGAAGGTGATTTATTTTCTTGGGTTTGGTATTAGGATGT CTTCTACACATCTTGTAATTTACATCCTGCTAGCACTTTCTCATAAAATCAAAAGGGATAAATCTACTCA GAGGTTGAGGTGGAAGGATTGTTTGAGCCCAGGAGTTCAAGTCCAGCTGGGGCAACACAGTTAAGACCCT GTCTTTAGAAACATCAAAGGGGATGAAAGTTTTTCCAGTGAAGATTTCAAATAATTTTTTAAAAGGAGTC ATTGAAAGCTGAATCTGAGTTTTTGCTGAGCCCCAAACGTTGAAAAGACATCAATTTTCTGCATGAAAAT AATGGGATAGCCATTCCCTTCTGCGCTGACCAATTCTTAGTGTAAACACCACACATGACTTGGTACTTTC TTTGACTCGTGCCTAGTTTCAAGTAGTCTCCTCTCTGTTAAAATTTATATTTTAGATTGGGATTGGCAAA CCACAGCCCAGGACCAGGTCAGTTGGTTTTTGTAAATAAAGTTTTATTGGAACACAGTCATGCCCATTCA TTTATGTATTATCTATGGCTCATTTTGTGCTACAACAGCAGAGTAGAGTAGTTGCCACAGATACTGCATG TCCCAAAAAGTCTAAAATGCTATGTGGCCCTTTATAGGATAAGTTTGCTGACTCTTATTTTACTAAAATA TCTATATTAAAATTTAGTAAAGGTCATTAGAAAAGGGAAACAATTCTTAAATTGTGACTACATTTTATGA TATTTTTTCTATGTTGTGAGAATATCAAGGCTATTTTCAATCACTGTCGGATGGACCCAGGATAAGTAAT CCAAATGTGACTGAGACCTATTTCATGCCTTAGTTCATAAGTGTAATTTGATTTACTGCTTGTCACCTAC AAGACTGCCTTTGAAAAGGGGAAAATTTAGTTATTTATTTCTCTATGTGACACAATTTTTAAAACTAACT ATTCCCTTTGTAAAAGTGGCATTGTTCGTTGTTAAAAAAAAAGATAATCAAATACACACAGAAAAAGAAA AAAAATCACAAAGATAGCATTTTGGTGAATACTTGATGCCATGTTGTACTGATTAACTTTTGTACCTTGT TGTCAAAATTAGTTTTGAGGCTGAGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTCGAGAGGCTGAGG CGGGCAGATCACTTGAGGCCAGGAGTTCAAGACCAGCCCAGCCAACATGGCAAAAACTCGTCTCTACTAA AAACACAAAAATTAGCCAGGCATGGTGGTGCGCGCCTGTAACCCCAGCTACTCGAGAGGCTGAGGCACGA GAATCGCTTAAACCTGGGAGGCAGAGTTTACAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTTGGCG ACACAGCAAGAGGCTGTCTTAAAAAAAAAAAATTAGTTTTGATAATCATGCATCAATTATAAGTGATAGC AAAAAATCAATGCCCTAATTTAATAATTACAGCTTGTTTTTGACCAAAAAATAGTATTACCCAGCTTGAT TATTTACCGTATGCCATAGAAGTTGGCCCCAGATATTTTCCAGCTGTTTATAAACACTAAATTCATTCTT AAACAATATATCCCAGTGAGGATACCCAAAATGAATCAGGGCCTCTGATAGCAATTCCCAAAGAAGAACC CCACAGATATTTTGAAATAAGTGTGTAGCCTTCCAAAGAGAAAGTTATGAGGAAACTGCATTCTTTTGGA TTGTTGTTTTAGACTGTGTGATTTAAAAGAAAAAAGCAGCCATAAAATTTATAAGGTTGCTTTATTATAA ATATTTGAAACTGGCTGACTGTTGAAATTTTCTGACCTTGGCCAGCACAGCACAACTGCCACCATTTAGA GAGCACTTGAAACATCTCAGTGCTCTTTTAAGTGCTTTACGTGTTTTATCCTATTTAATCCTCACAGCAA GTCCATGAGGTGCAAATACCCCATTTTATAGACGGAGAACCTGAGGCTGAGAGGGGTTGAGAAACTTATC CCACCTGTAAGTGACAGAAGTCAACTTCAAAGGCCATGTCTAACTGATCCCAAATGCCATCCTCCTGACC ACCATGACCAGAACCGAGATTTCTTAACCTGGGGACTGCAATTTCCTGGATGAGTTTTGGGGGACTGTGA ACATCCTGAAACTGAACACAAAAATGCTGTGTATTCACTTTCCCAAAGGCGGCCAGTGGCTTTCATCAGA TTCCCAAAAGGGTGCCTGGCCCATATGAGATTAGGAACCACTGCAGCAATAGAAAGGAGAATGTTGTCAA TGATTTTATCTTGAAATTTCCACTGAAGTGTAATCTGATTGTGCAATGAAATTGTTGCATGCAGCTGCCA AAGCCGAGAGACGGAATGGGTGAGGACATCAACCACTCATTCATAAGGGTTGGGGCAGGGGCTCACTACA CAGGTAGTTGTCACTGTGAGGCTGACAACTCACACTTCACAGGACTAGCGCAAGAATTGTGTCTTGGCCC CAAGAGGTTCCTCTGTGGCTGCCCTTGCCATTCACCCACTTTCCAGCAAGCACAGATGTACAGGTATCAG GGAACATGGGGAAGAAACCCCAGGCTCCAGAAGCAATGGCACAGGCTCACCTTCCAAGCTCTGCTCATTT CGCTGGGACTCATTTCCCAGGGATCCCTCACTCTGACCCATAGCCTTCCTGACCTGTTGTGTGAAACTCA CTCCACAAACCCTGTACTTTCTGATAACAGCTCTCTTCCTTTTTTATCTGGGCCACCTCTTGGTGTGGTG CAGGGATCCTGATGTGGGAGGTGTTCAGCCTGGGGAAGCAGCCCTATGACTTGTATGACAACTCCCAGGT GGTTCTGAAGGTCTCCCAGGGCCACAGGCTTTACCGGCCCCACCTGGCATCGGACACCATCTACCAGATC ATGTACAGCTGCTGGCACGAGGCAAGTGTATTCTCTGGGTGGGCTGGAAGGGGTCTCAGGCACATCCGGG GTGATTACTGCATCACCACTGGGACAAAGCTTTTTTGAGGGAAAGCAACTGGTACAGAGCAGGAGAGAAT GGTCCTCAGCCCCTGCCCTAAAATGTTTGTAATCTAAAACATGCGGGTGCCAAACAATTTACTGAACAAC TTACATACAGCAGTGTTCTAAGAACACTATAAATATTAACTTACTTATGCATCAGGAAACACACTGAGGT AAGTACTATCATTGCTGAAACTAACAGAAGAGTAAACAAGGACTCAGAAAGGTTAAGTGACTTGTCCAAG GTCACATAGCTAGTAAGAAGTAGACTAGCTAGTGCCAGCGTCCCTGTTCTTAACTGCAACACTATGGAGC TCCTCGAGTAGAAAATAAGTAGCAGAAAACATCTAACCACACGTAGAGAACACATAATGGACACTATCCC ATCTTCTCTCCCCCTGCCTCCCAAACACTGAATAAAAGCATTCCATGCAGGTAGAAGATAAGGGTATCTT ATGGGGAAGACATGGAGCTGAAGCTTCAGGGGATTAATTTGCAAAGCATCCACTAAGTTCATAGAACTAA TGGAGGTTGTTAAGGAAGTATGAGGCTCCATTTGTGCCCTCACTGAACTCAAAGTCTTTACACACACACA CACACACACACACACACACACACACACACACACACAAATAGGACTGAAAACACCAAGCAGTTTATAATTA TGTGCCCAAATTAGAAAGACAAGGTTTTTGCCATAACTTTCAATGGCAAAAAACGTGATTACTTTTGCAC CAACCTAATACAAGAAGCGCTCAGAGGAAAGAGAAACCAGCTTCCTGAGAGAAAGCAGCTTCTTGAATGC ATTGGTACCTGAGCTGAAGCAGGAAATCTCTACAAAATTTCCTAAGTATGTGAGTGGAGACATTGTAAAA GGGTGTCCAGGTGAGAACAGCACAAGCAAAGGTGTGGAGGCAGGAACGAGCATGGCACGCTAGGCTGGTG CTATCGTTGGAAGGGCTGGAGATAAGTTTGGAAGAGTAGGTCTGGTTCAGGTTCTGCAAAGTGAATAACA AGGAGACAAGTGAGAGTTTTGGTTTTTGTAGGCGATGAGGAGCCACTGAAGACTTTTGAGCAGTAACATG ATAAAAGGAGGCTTTTGAGAACATTATTCTAAGAGCCCATGTTCATAATCATTATATGGTACTTCCTCAA TGGCAAAGGGCCTAATGCTGCATTCATTTATTCACTAGTAAAAGGCAAATTGGTGTAATGGTTAAGCCTG TGGGTTCTGGCATCAGAATACCTGGGTTGAATCCTGTCGTGATCACTTACTAGTTATATGACCTTGTACA AACCTCCTATTATTATCTCTGTGCTTCACTGTAATGTAATGCTTACCTCATAGAATTTTTGGGTGGATTG AATGAATTAGCATTATAAAGGCCTTAGGACAATGCCTGGTACACAGTGCTGTTTTTCTGTTATTAATATT GTGTGTGTGTGTGTATATATATATATATTTTTTTTTTTTTACAAAGCATCTATGCACCAGGCAGTACGCT TGGTGCTAAGAATAAATTGACGCACACAACTTAAATAGTTTCTAAACTCTTGTACCGGAGCCTAGAGTCC CACTTTGGAAGAGTTGCTGATTGCATCACATAACAATATTTTTCGTTTAGCCTTAAATTATCACCTGGAA TATGAGCACTCTGTAATTTCCCACCCTATGGCATTTGGAACAGTATATAAGGTTTCCACACCTTTTTCTA CCCCAAATGTTGACTATGGGAACTATGGATATGGACAGAGATATGCAGACTACAGTGGCCAACAGAGCAC TTATGGCAAGGCATCTCGAGGGGGTGGCAATCACCAAAACAATTACCAGCCATACTAAAGGAGAACATTG GAGAAAACAGGATGAGATGTTAAAGTAACCCATCTTGCAGGATGACATAGAAGATTGGTCTTCTGTTGAT CTAAGATGATTATTTTGTAAAAGACTTTCTAGTGTACAAGACACAGTGTCCAACTGTATATGGCTGCCAA TTAGTTTTCTTTGTTTTTACTTTGTCCTTTGCTATCTGTGTTATGACTCAATATGGATTTGTTTATACAC ATTTTATTTGTATGATTTCATGTTAAACTTCAAATAAATGCTTCCTTATGTGATTGCTTTTCTGTATCAG GTACTACATAGCTCTGTAAAAATTTAAAGTAAGCAATAATTAAGGCACAGTTGATTTTGTAGAGAGTATT GGTCCATAGGGAGAAACTGTGGTCCTTTATAAATAGCCAGCCAGGGTCACCCTCTTCCCCGATTTGTAGA TGTATTCTATGCTCTTAAGGTTTCATCTTCTCCCTGTTAACTGAGGTTTCTACCACACTTTTGAATAATG TTCTTTCCCCTCTGGTTATCTGAAGATTGTCCTGAGAGGAAGACATAAGTGTTGTGATTAGTAGAAACTT TCTAGTAGACCATGTTTCTTCTGGATTGTAATAAAATTGTTAGTAGCTCCTTTTGCTTTGTTCCTGTCTC TAGAAAGCCATCTTTGAATCGTTAATTACTTTGGCTTTAATCAGTGGTCACCTAGAAAAAGCTTTGTAAT CATAACACCATGACTTTAATTCTTGATAAAAATTCAGATGCACACAGGAAGGAGCACTGTAAAACTGGTA GGAGCTATGGTTTAAGAGCATTGAAAGTAGTTATAACTCAAGGATTTTGGCAGAAAGGTATGAGTTTGGT CAAAAGTTAGATTAAAATTTGAAATAGCGGCAAAATAAGATTTAGTTGTATTTTGTTTTCTCACAGCCAC CACAAGACTGAACAAAATATTTTCTGTTTGGGCATTCTGAGGAAGCTGTATTACAGTTAACTGTTAATGC TGTGTGAGTTTAGAAAAAGTCTTGATAGTAAATCTAACTTTTAACACAGTTAGTGCATGAACTGAGTAGT TAAACATTTCCGTATTCAGACAGGAATAGTGGAAAAGGTATCTTAGGTGCGTTACTCAATCCAAATGTGA CTGAATCATTACAGTGGACCCTCATGGTGCATTGAAAAGAAACTGTTTTATATCCAGGTTTCAGAGGACC TGGATAAATAAAAGCTTTGGATTTTGCATTCAGTGTAGTTAGTTGGATTTTGGGACCTTTGCCTCAATGT TAGCTACTGGGATTGGCATATGTGTTCACAGGCAGAGTAGTTGATCTCACACAACGAGTGCTCTCACAAA ACTGGTGTAAGTTTCTTATGCTGATGAGCCCCCGCTTTTTTTTAATTTGGTGCCTACAACTTTGTTACAA TGATTGTACTTGCTGGGCTATCAAGTTACAATGCTCTTGGTCTTTTTTGCTGCTGTTTCGCTATTTGTCC TTACACCTAGGCCAAGTACCAATGTTAGCTGTTGGAAGGGATTCTGTTTATTCATTCAACATGCAACTAT CTAACTTTAGGGAATGGAAGGAAGTTCATTTTTAAGTTGTGTGTTGTCAGTAGGTGCAGTGTCTAGGGTA GCGAATCCTGTAAGTTCAAATTTATGATTAGGTGACAAATTGACATTGAGATTGTCCTTTTCCCTGATTA AAAAATGAATAAAGGCTTTTTAAAGAAACAAACAAACAAAAATATTGTGTCTAAGATTATCAGGCAGCAC TAGAGGGTCAGACTGGGTCTGGGTAGAGTTGGTCACAGCCAGGCTGACTTACTGCTGTCACCTGTCAGAT GAAGAAGAGCAGACAAGGGTTTTTCAGTTGAAGCCCAGAACCTCCCTGGCCCTCCCTACTCTAGCTCCTG GGAATATGACTGCACCATAGGATGGACAGGGGCCCTGAGTCGGGAGGAACTGCCTTCTTCTCATGGTTGG TTCATAAAAGCATGTGAATTGTGGCAGAATCTGTGAAGAGGGGTTTGCACTGAGACGACAATATCCAGTT AAAACATTGCACCTAATGAGCAGAGCTTATAGATTTGGGTTTTCCCTCCTTTTTTAGATTTTATTTTGTG ACTTTCTCAATTCATAAAGAGATTGAAAGAACATTCACAATTTTCATTAGATTTTGATTCATCCTTCTGG TATTTCTGTATGCAAAAACAAGCATATGTATAGATGTGTGTTTTCTTGCTTCCCTTTCTCTCTTACAAAG AAAAAGTAGCATATGAACTTCTCCTCTCCATAGGCGTTGCCTCACTAGCAATGTAAGAGGGTACCTATTT TCTTATAACCTCACCAATGGAGTGCATTGTCAAGCTTTTGAAGAATTCTTGCCAATCTGATAAGTGAAAG CTTGATGGCATCTTAGTGCAGCTTTAATATATATATCTTTCATTATGAGGTTGAGCCTCTTTTCACGTTT TTAAGGGTCATTTTGTGTCTTTCTGAACTGTCATGTCTTTTTTCTTTTTTCTGTCAGGTTTTAAAGATCT CTTTACAAATTAGGGAGAGTAATACTTTAAGTTATCAGCTTTATTTGATTGAGGGTGGGTGGGTTTTTTT TTCTTTTTTTGACCATGCAGAAATTTTTCTTAATATAGCTGAATATATCAATATTTGTTTTCATTGCTTC TGGAAATTGTCATAGATAGGCTTTCTCATGCCCAAATTATAATGACTTTTGCCAGGATTTTCCTCTAGTA CTTTTAAGATTGCATTATTTTCCATTTATGTTTCTGATATAGTTTGTGTTTGTTATGGTATATGGTATTA AATATGGCTCCAAATATATAATTTTATGTGACTATTCTGTTGTTGGCAGCCCTATTTATTAAAAGACCAT CTTATCATCAGGAATGAGATACCACCTTAATGGTGGTGAAATGCCACCCTAATATTATACTAAATTTCCA TATGTACTTGAATCTATTTGGAGACTTCCTCTTCTGTTCTTTGGTCTCTTTGTTCATGTGCTAGCACCAC ACTGCTCTGATTCTGTAGAGACTTTATGATATGTTTGAATACTAGGTAGGCTAGCACCCCTCATTGCTCA CCTTACTGTATAATTTCTTAGCCATTTTTACATATTTTTTAATTCTATAAACCAAAGAATCAATTTGTTT AGCTTGAAACAAACTCATTCATATTTTTGAGGAGATTGTATTTAGTTTGTATTTTAAGTTGGGAAATTTG ACATCTTTATGATACTGACTTGTCCTAGTCTAGAACGAGGGAAGCTTTTTTTTTTTTTTTTTTTTTTTTT AAGACAGAGTCTTGCTCTATCACTCAGGCTGGAATGCAGTGGTATGATCTAGGCCTACTGCAACCTCCAC CTTCCAGGCTTAAGTGATTTTCATGTCCCACCCTCCCGAGTAGCTTGGACTACAGTTGTGCACAACCACA GCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGTTCAGGATGGTCTCGAACTCCT GGCCTCAAGTGATCCACTCACCTCAGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCTGG CCAGGGATGCTTTTTTATATAGTCAAGTCTACATTTGCATTTTTCAGCAGTGTTTTAAAGTCGTCCCCAT TTTAGAGGGGCACACTTTTTTAGTGTTTTATTTTGGTGGCGTTGCTATTATAAATGGGGTTTTCTCTTAC ATGATAACTTCTAAGTGGTTACTGTAGGTATATGTGAAGGCTATTGATTTTGTATGTTAATTTTATATCC TGCTCTCCTAGTGAATTCCTTTATTCTTTAAGTCTGTTCTAACATTGATACTCTCAGATTTTCCAGGTAT ACACTAAAATGCTTGCAAATAAAGAGACTTTTTCTTTTCCAGTTATTGGGGCTCTAATTGTTCTTGCTTT CCAATTGCATTGGTTAACACCTTCAACATAATGTTAAGAGTGATTATTATAGTGAGCGTCCTTGCCTTAT TTCTGACCTCAATTGAAATGTCTGTTGTGTTTCCACATTTTAAAAGTTGCTAGCTTTAGGACTTAGATGT AAATATTTTATATATTTTATCATTGATCATAACTCTCATCATCTAAAACATTGGGTTTCTTGTTGTTTTT GTTTAGCTTCCAGAAAAGCGTCCCACATTTCAGCAACTCCTGTCTTCCATTGAACCACTTCGGGAAAAAG ACAAGCATTGAAGAAGAAATTAGGAGTGCTGATAAGAATGAATATAGATGCTGGCCAGCATTTTCATTCA TTTTAAGGAAAGTAGCAAGGCATAATGTAATTTAGCTAGTTTTTAATAGTGTTCTCTGTATTGTCTATTA TTTAGAAATGAACAAGGCAGGAAACAAAAGATTCCCTTGAAATTTAGATCAAATTAGTAATTTTGTTTAT GCTGCTCCTGATATAACACTTTCCAGCCTATAGCAGAAGCACATTTTCAGACTGCAATATAGAGACTGTG TTCATGTGTAAAGACTGAGCAGAACTGAAAAATTACTTATTGGATATTCATTCTTTTCTTTATATTGTCA TTGTCACAACAATTAAATATACTACCAAGTACAGAAATGTGGACATTTGTCTTAATATTTCAATGTTTTC AAACTTCAGTAGGCATGATAATCAAATGCAGAGTTTATGAAAAGATTCCTAGAAACTACCTCCATAAAAC CTGGCGGAGGAGGTCTGAGTGCAGCCTGTGAATTTGTATTTTTAGCAAACTCCCAGATGTTACTGAAGCA GTTGTTCTGAACTGCCCTAGGGGACCTCATTATATGGTGGGGTATCATTAGGTGGTCCATTACCCAATCC AAATGGCACAATTCTCGTCTAATATCCAGATTAGTACAATGACTCTTTATGTCATGTATAAAACTAAAGT TAAATAATATTAAATAATACATTAAATATGTTCACATAAAGCAAATTTTTTAAGATGCTGAGGTACAATT TCTAGAATTAATTACATTGTTGCTTTCTAATCATCTTTTTTTTTTATATAAGTAGACAGTTTATTTGGGT CAAGTTTAAGGATTATAACCTGGGAGCAAAGACTCAAGTTGCCTGGAATCTACACTTTGATTAGCAGCAG TTGCAAGAGGAGTTGTAAAGACAAAAACAAAGGGACAGAGAGTGGGCTGATACAGAGTTGTTTGTCAGAA ATTTTTATTTATTTAAAGAAATAACATTGGTTATTGATTAGATATATATCATTATGGTTTAGGGTATGAG ATATAGTGTCCAATGTGGTATTATTAGTTTAATATATATCTACTTGTGGCAATAGTGAACAGTTTCAAGA GATGAATACATAATTTAAAGGGGGAGAACGACATAACTGCACGTTCATTTCAATGTCTGAGTTTGATAAC CAAAAGTACTTTCATTTTTTAGATAAAAATTTTCTATTTCCCAAATCTCAAGACCTGGATACAAAATGTA GAGCTGCAGATTTAAGGCCTGAATGGCTGGAGTAGCAGGTGTTACCTGAACATTTGTGAACATTTTACCA AGAGAAAAAAGGGGAAAGTGGAGATTCTCATGTCTACATGTGTACTCAATGAACACATGTTACTCTGATT AGGTTTGTGGGCCCCATGGTCTCCGAATCAGTTTCAGGTCTGAAGATAACAAGAGTCATTGAGGGAAATA AAACGATTGATTGTTGCCCAGTGAAGTTGGTAGAAATTAGGATGAACTATGTATGACATGGTGCTGTAAA TTCTTCTACTTGTGGACTAATTTTGGTGACCATCTGTCTAATCATCTTAAATCCTTGAGTTTGGGGATCT GGGGCTTCTGGCTAGTTTGATAACTGAAGTTTCTATTTCAGTCTGCTATCTTAACACAAAAATACAGAAG TACTATTTTAGCTTCTCATGCCTATTACTAAATAGTATTTCACCTTTAAAACAGTACCTGCGGATGCCCT TCTTCACGGCCTGCTACCGAACCCACAGGTTTTAACCTCTTTCTGAGTATTCCATTGTCTTTTCTATAAT GTCAAGAAGGGAGAGACAGATTCTGTAGAGGGCACCATTACAATGAAGAGACACCCCAATTAAACCCTGC TGCTATTTTCCAGAGATCAGTCAATAATCTCTCAGAGACACTTATATCCTCTCTCATCCCACTCTGTCCT TCAGCCACCAGCTAGTTTCAATGCTCCCTCTTGCTTATTTGTTTCTTGACATTTCATTAATAATTCCTTC ATTTCAACACAGAATTGACACTCGTTAACAGTCTTCTATTTTTTACAGAGGTACACAAATCTCAATTTAT AATTAAATGTAACTCAAAATAATCACTAGGGCATTTGTATATTTTATTTTTGTGGGTTTTTTTTGTAGTG TTGACTGTATGCTAGGTTCTTTCCTACCCAAGAGAAAAGAAAGAACAGGTGACCCAAACCCTCTTTCTCA ATGGACCCACAGTCCGATGGGGGTGCCAGCCTTTCCTGCACCAAAGACTGTTTCCCCACTCAGAGGATGA GCTCATGCACAAGCTGGGTCTTTCTGGTCTCCCTCTCGAAGATTTTTTTCCTTTCTTCTTCTTATTTTTG TATATTTACCTTTTAAAAATAATCCTCTTTATAACAAAATACACGCTTGTTGCAAAAATTGTTTACTATG AAAAGAGGCCAAAGCCCTGCTTAGAAGCCTAGCTGCAAAAATCAAGTCAGGCAGCAATTTAAGGTACCAC TAGAGGTTTATCAGAAAACAAGTCCAGTGATGCTAGGAGGAGCCAAGTAAAAGAACACTATTCATAGTAT TTCAAACGTGCACAATGATTTTTTAATGCTGTATAACTGTGTTTAGTGGTGATATGCAGAATTTATTGTT GTTATCTTAAACCAAGTGTCTGCCTACACTCTTTTGGCAGTGAAGAAAAAGGAAGACTATGTGGTAAGAA ACTTTCCCAAAGGGCAGGCTGCAGAGCAAGTTCAGATAAATCACTTGCTAGGTAAAATCCAACAGATGCT CCCTCGTCTTGCTGAGCATTTTCTGACCTACCAGAAGTCAAACACAAAGTCAAGAGGGTCTGGCAAAACT CACCTCATATCTACTTGAGTTTATTAAGATTCCAACACAGTAGATTTAGCAAGTTGAGTTTCTCAGTTTT TATTCTATCTTGAGAGTGGGTTTATGAGGAGGAGAGATTGGACCTAAGGCCCCATCTTTACCTAAATGTG GAGGGAGGAGGCTCTCAAATTAGGAAGAATAGTTCATTGAGAGACACCAGAGAAGAGGAAGCTAGCACCT GCCATTTCTGGCCTGATCACTATGTTTCTCTGGTCTGTGAGCTCCACAATGGACCTTTTGCATTTGCAGT TTCATTTAATCCTTGCTTCCGTATAGCCCAGGGTTTGGCAAAGTTTGTCTGTAAATGGCTTTGTGGGCCA TGCCGTCTCTACTTCAACTACTCAGCTCTGCTCTGTAGCATGAAAGCAGCCCTAGACAATATGAAAATGA ATGGGTGTGGCTGGGTTCCAATAAAACTTTATTATGGACACTGAAATTTGAATTTCATATCATTTTCATT TATCATGAAATCTTATTCTAATTTTTTTCAACCACTTAAAAATGTAAAAATCACTCTTAGTTCACAGGCC AGACAAAAACAGGTGGTGGGGTGGCCGGGCACAATGACTCAGGCCTGTAATCCCAGCACTTTGGGAGGCC GAGTCAGGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAAATGGTGAAACTGCATCTCTAC TAAAAAATACAAAAAATTAGCTGGGTGTGGTGGCTCACACTTGTAGTCCCAGCTACTCGGGAGGCTGAGG CAGGATAATCACTTGAACCCAGGGTGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCT GGGCGACCGAGCAAGACTCCGTCTCAAAACAGAACAGAATAAAACAAAACAAAACAAAACAAAAAAATGT GGTGGGCAGGATTTGGCCCATGGGCCATTGTTTGCCAGCTTCCATCCTAGGCCCAGGCACCGGTCCCTCT TTGTAGAGTCTCCATCCTTTCAGAGGATGCTGCTACACAGGAGAAGGACCACAAGCGTTACCTGGTGGGC ACAGTGAGGACTGTTCTGGAGAAAACCCCAAAATTAAGTTACGGAAATAAGCAGGTTTTTCTTTCTGTGT TACAGTTGGACACTATGTCACATGCACATGGGTCCTTTGCCATGTCTGGGGAGGCTCTTTTGAAGGTGTT AGATGATGAAATTGGTTCCTGCAGAAATTATTCTTGCACTGTGCTGAACCAAGTTTATGAACTTCATAAA GATCTTGTGGCAACTACAAAGGATGTTTAGATAGCAGTAGCTTGACAGAAGATTTTCATGATATATTAGA GAAGATGGGACATATGCAAGATAAAAGAAAAAACTGTCTATGAAATGGTTGCTTAGCCAAGGAGTAAATT ATATTGTATGTTGCCCCAAGCTGTGGGCCCAGTGAATGGCAGGATGGTGCAGATGGTGATGCGAAATGTT GATTGTATCTCGTAAAATAACAAAGAACTCTATCTCTGCTACCTGGGTATCAGATAATTAAGACATCAAA GAGCCTCAAATGACCCTTATTTTGAGGTTATTTTACAGATTATGAAAGTCATCTTCCCTTCACTTGGCTA ACTGATCCACAATTACCATAGAGAATTTATGAAGTACAAAGTCATTGTAACATTATGCTGGTCACCACAT AGAATGAGTTAATGCATAGAGTTTAGATATGTTAATCTATTTAATCTAGTTTTAACCAGTCTTCAGGTAT CTAAGAAATGCTGTGCTCACACTGGGGTAGTGACTGTGAGAAATATAAAAGCAGCATCAGGTTTGGTTCC TAACCTGATGGTGTATACACTCTGTACACAACTTTTTTGGGACTAGTTTTACAATTACTTTGTACAATAA AGCAATCTGAGAATTTGCAATACATCACGAGACATTTGGAAGGCCAGGAGCCCCAGACACTCAGATGATA ACTTTGTTCATAGAACTGAAAAGCAGACAAAACGTAAAGAAGCCCCAGCACATAAGTAAGCACAAGGAGT GTGTAAATCTAGCATTTATTGAGTGTCTGCTTTGTGCTCAGCACTGCTCAAACACTGTGAGCAAATACAA AAGATTTAAGAGACTGGGTACCCACTTCAGAGGGTGAACATACAGTTGGAATTTCCATTCACTCCACAGT TAGAGAACAGTAGAAATGAGTTTCTATCAGGCATGCTCTGGGAGTTCACGGAGGCCCCTGGCTCTAGTTT TGTGTTGTCAGGGAGATGTTGATCAAGCACCTTGGAAGTGAAAAAGCAATGTCCTCTACCTGTTCCCTGG ATTCTTCTCTCTTTAGACCTGTCACCTTGAAGAAAGCATGATCGATTCCAAACATCACTGTAGGCAAATC ACCATAGTACTTGAACTGAGTTACTGTGAAGAAAGCATGTCATCCTTGACAATGGATTAAATGAAAGTGA GCTAATGCATGCCATTCTCAATCCTTGCAGCTACACCAGTTCCCAGGCACTGTCCTTACAAGTGATCCAT CCATATTCCATACAAGATCCAACACTTGCTCCAATGATATATCCTTGTTTTCAACTTCAGAAATTCAACA GACATTTACATTTAGATTATCCCTGAACAGCCTGTGAGACCAAATACACACTTTCCCTAATATACTCTAA TACAAAATCCTTATTAAGAAACAGAACAGAAGTCAAATCCAGAGACAGAAATAAATACTGAAAGCAATGT CAATGAAGATGCTCTCTCCTTGGCCATGTTGTCTTTGGACAATTTTTTTTCTGAACAGAGTCATAGTTTT GACATTTAATGATATCTTTATCATCTTATATTTTCTATACCATGAAATTAACATTTACATACAACAAAAT CACCTCAAGAGGAAAAACATAGATTTTTCTAAAAGGAGGTCTGAACATCATCAGTGTTTTGGAATCCTGG ATTATTTTCTCCTTTGCTAATATCGATGGAGGCATAAGGATTTTCTCCACTTCTTGCTTTATTTTTCCTG TTAAATAGAGCAAGGTTGCCTTAATATACTTATGTTAAAATCAATCGGACTGATGAAAATCAAAAAGTTT CAGGGGAATCTGTGTTAAGGAGGCTGGGAGGGAGGAACAGGAAGTTTCATAAACTGTTGATGTGAGTATA AATTGGTACAGCCGCTATTGAGGGCAATTTGGCAATATTTATCAAAATTAGCAATTGCACGTATGCTTTC ACCCAGCTTTCCCACTGCTAGGATTCATCTTAAGGGTATATTGGCATACTCAGGAAATTACCTATATTAA GCCATCACTTTTTTTAAGTAAACACAAATGTTTGGAAACAACATAAAAGTTCATCAATAGATGACTGTTT ATCAAAATTACAATCCATTCGTGAAATGGGAAATTATACTGCCAGAAAAAAGGAGAAGTTTTTTGTGCAA CTAATGTGTAATGATCTCTAAAACACATTAAGTGGGCTGGGTGTGGTGGATCACACCTATATAAATAAAA ATTTAAAAAAACCATTAAGTGGAAAACAAAATATGCAGAACATTGTTTATAGCCTGCTAACATTTGTATA CTAAGAAATGAGATATACATATGCACATACACACAAATATACACACTAAAAAAGTATATATTTGTATACT AAAAAGGAGATATATATATATATATATATATATATATATGTCTGAGAAAAAAGAAAAAAGACTGTGTGTG TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATCTCCAAGGAACTGATAATTTTGTTTGGCTTTGGGA AGATAACTTGGAGGCAAAAGGTAATAAGGAAGACTCTTCATGTTCACCTTTGTATTTTTTAATTTTAACC ATATGAATGTATTACACATTGAATGCCTAATATTTTAGATGGAGCTATTTTGGAGAAACGAAAAATCTCT ATAGTGAAGAAAATTGAGCAAAATAGACTAGCAAATATAGAGATTCAATCAAGAATATGTTTAAACAAGC TGAGGTGTGCATAGAGTTTTGTTAGGTGCTATAAAATATTAACCTTCATTCCATAAGCCCAGCAAGAGTC AATTTCTTAAGGACAGAAGAAAAACATCTAGTAGCAAAGCAAGACTAGAAATCAGGTCTCTGGTAATTTA AATCCTCAATGAACTTTGATCTTCAGTTCAGGAACAAATTAGAACGTGCCTAACCATGAACTAAGAGAAT GACATAGAGTCTGAGCTACCCGGTGAGAAATAAAGCTGAGTAAAGAGTAGCAGTTTGGGCAGGGCACGGT GGCTCACGCCTGTAATCCCAGCACTGGAGGGCGAGGCAGGCGGATTGCTTGAACTCAGGAGTTCAAGAAA AGCTTGGGCAACATGACAAAACCCTGTCTCCACAAAAAATACAAAAATTAGCTGGGTGTGGTGGCACACC CCTGTAGTCCCAGCTACTCAGGAAGCTGAGGTGGGACGATCACTTGAGCCTGGGAAATCGAGGTTGCAGT GAACTATGGTTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAACAAACAAACAA ACAAACAAACAAAAAACCAAGAGTAGCAGTTTCAAAGAAATCTCACAGCCCATTCTTGAACAATTTCACG GTTCAAACCCATCAGCAATCCAGTCTCCAGCAATCCAGTCCCCACTTTTAGACTGAAAAGGATTCAGCAG TGAGAGCAGTGAAAACCATTCCCTGAGCCCACCCATACCTGCTGAGTTTGCAGTGCCTCTTTGTAGGAGG GAAATGACACTGTGGCTGGGATGGAGTTTACTAGGGCATGCTAATAAATCCCAGGCCAGATACTTACTGT GTGGGCTTACTAGGAAGATGAACTGCTGATCTATTAAATTTCTAGGGAATGCATCAGAGTATTTAGTTGC AAAATTGTCCAACTAAGTAATTGGTCTATACAATCTACCACTTACTGAAAATTTTCCAGTTACTGTTCTC TAAATCTTTCTATTTTTGGATAGTTAAGTCTAGGAAAGGCCACTTACTTCTTCCGATCTCTGATCCCAGT GAAGATCAGGATGACAATGCCAACCACTATCACTCCCATCACAACTCCAAAAACAATCAGCCATATGGAA ACAGGGGGCTGGTTAGGAGGTCCAAGTGTTGGCTGTATCCCCAGAAACTCTAGGCTGTTGTCATTCAGAC GGAAAGCATCATTGATACGGCTCCGGGACATCCTATTTGCAAAAGCAAAAAACAGCAAAGGGGACACTTA GACAAAATAAAATTGTGTGTAGTTATTTACTGTTTATATCATTGTTCCTGAAAGGATATAATAGAGCTTA TCATAAGAATATACACCTAGCCAGGCATGGTGGCGCATGTCTGTAGTCCCAGCTACTTGGGAGGCTGAGG CAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCCCTCTAGCCT AGGTGACAGAGCAAGACTCTGTTTCAAAAAAAAAAAAAAGGAATATACACCTAAAATCATAAGAGCAAAG TAAATAGGTCTAATTAAAGATATAAGTCTTTGACAATTATGCATCTTTCATGCCTTGCAACCTAGATTAG GTTCATCAACAGCTCCATTGGAAAATTGAGTTGTAAGTGTGGAAATGTATAAATGGTTGGCATTTATTCA TTTGTGACTGCTGTGTTTAAGGGCAAAGTTATCATATTTGGCAAGAATTTCCCTTCTGTCAGAGTACATC TACAATGACTTTATATCAAATAATGGAAACGGATAATTGGATACACCTCTTCTATTATACAAATGAATCA GGTCCTATGACCAAGTCTCTATAGTAGTATTTTCCAAATAAAAGGTATTGGCATTTGGAGGTAGCACTGG GGAGGCACATAAGAAAGGGACCTTTGCCAGTTTCTTCAGCACTGGGATGGGAAATGGCTTACTTTTATGG AGGCAAAAGGATAAAGATTGTTTAAAGAAAAAAAAAAACAATGATATGGAGAACATTCTGGATCAAAGAC CAAAGTGTCTGGCATCTCATCTTCCTACCCTTGGGTATAGCCCAGGTCAGGAGGTCAGAGTCCACCAGAG AGAGAGAGAGAGATCAACGCAGAATTAGTCAGGTAACCCCTGGCAACCTCAGCCAGAAAAGATCTGAAAA GAGTCATCCTGGAAACAGAGAGTCTGAGGTCCCCTGTAGCTTGCAGCTGAGTATCCAGGAAGGCTGAGCT TTTTCATAAAGATCTCAGCCAGAAGTTTTTCCCAAGACAGACACAAGTCTTCTGGAGGAAGTGAGTGAGT CTCTGGGCACAGTTGGGTCATACACTCCAACCAAGCCAGATTTTCTAGGCACACCCTGCCCAGCAGGTCT TAGATCTGCTTCCGAAGTTAAACAGGACTCTGACGCAGCTCGAGAGGGCCACCTAGTGAGCTGCCCAGAA GCAGTAGGTATATTAAGCCTTTTTATAATGACAGGAAACCATCTGCAAGGTCAATCCATTCTTCGCTCCT GCTGTCTGTTGTGGGAAACAATTGAGGCAAATTGGACAAACTGTTTCTTCTAAACATTCATTGCAAGTCC CTCACCTAGCATAGAGGCCAAGCAATATGTAAGGAATCCTGTACTTGCCTACCTTGTTTCAGGATTTGGG CAGTTAAATGAATCCTACATCAAAGTCCTGAGAGCAAATGATGGCAATACCTGTCCACGTCCCTTCTGCA CTTACTATTTTCCATGAGTTCTAGCCAGACTTTCTTCAACCAGCACCTGCTCCCCTTTACCAGAGAGCAT TCTCAGACCACAAGATCTGCCCTGCCTGCAGGGCTGAAATGCTGGGGAATTAATGCCACCTGGAAGCAGT TCTCAGCCAATAACTGATGGGAGGTGGTAAATAAATACCCCAGCTTCCTCAGCCCTCTGATGGGACAATT CAGGTGCACATTCTACACAGTCTCTCCACATTTCCCAGCAGGACTGAGCTCTAGTTGCCCATAGTGGTAA CTTGCTTGATAACATGTAATCTATAGTTTTTCTTCCCTTTTGTAAGAGCCTACATCTGGCGGAACTCAAA TCAAGATTATTCCCCTGCTGTGGGATCCTTCTGGAATTACGTGGAGTTTGTAGCATGAGGTAACACATGT AAATGACTCAGAATAATGCTTGGCACACAGGAAGAACACACAAAATACTGGTTATTGTTGTTGTATTTGG TAACCCCCTCACCCTTAGATGAAAGTAAAATGTCACCTGATGGCCTTTTCAACTTCAGTTCTAGGAATGA TATCAGACACATTTTTAGGTGCAGTGACAAAGAAATTAAAGGAGATTCTTGGTTTCAAATTAGCCACTCG CACATCCTCCTCCCTGTAGAGAAACAAAACAAACATCTTCACTTGTGGCACAGAGGACACAATCAAGAGA ATGAAGACTTCCCCTGCTGGTGAAAAGGAGATTAGAGAGAGAATCACAGGATAGAGAGACATGGGGGAGG GCAAACAATGAGAGGATGTAATTGTCAAAAAAAACATTAATGCTGCCCAAAGCACATGAAATCAACTACA TAAAAATTGTGATATCAAGTTTTGGCACTATTTGTTCTGCCTTTATATAAAACCCACATCTTTTTCAATT ATAGAAAATTTCCAAACTGAAAACAGCAGGAGAATCAACAAGGAATAATCGGTGGCCCAGGATTGTGGCA AACAATGTGGTGGGCAGAAATGGCTGAGTACCACACACGGATTTACACCCACAACCTGGTCCTACCCAGC AGAAAACGTCGTGTTGCACCCATGGATGAAGGTAATGAGTGGGGTCTACCATATGATGTGACAGGACTGT GCTCTCACAGCTGTCAAGCGATCCTAGCACAAAATAAGGTAGATCATGTGGCTCATAGCCCTTGAGTGAC TACTCATCTAACTCAGAATAAAAGCCAAAGTCCTTAGAATGGCCTTCAAGGCCCACATGACCTTTTGTCT CTCCCTCCTTCCTCTATGCCCTAACATCGTCCTGGCCATGTCTCCACTTGTCTTCTAATCTGCTCCAGCC ACACTGGCCTCCTTGCTGTTCCTTTAACAGGCTGAGGATATTCCTTCCTCAGGGTCTGCACCTGCTGTTT CCCCCAGCTGAGACACTTTCCCCATTGTCTGCATTGCTGGCTCTCGCTCTCGCTCTCTCGCTCTCTCGCT CTCTCTCTCCCTCTCTCCTGCTTCATATACTTGTTCAAGTATTAGTGACGTCTTTTCTGACCATTTTGGT TAAAATTGACCTACCCCCTGCCCAACACACACACACACACACCAGCCCTCCCCAGACCCTTTTATATTTT TCTCCTAGCACTTAGTACCTTGTAACTCTATATTTCACTTACATATTACACACATAGACACATACACAAC ATACATACTAGAATATAGGTCAATGAAGGCAGGAAGTTCTGCCTTTTTTTTCTTTCAGTGCTGAGGGTGT ATGAGAGCATTCTGAGAAGAGAGTGACAGCTGTTTAGTAAGAACAATACTCTTGCAATTTACCAGTCAAA TAAGGCACGATCAGCCCTCTATGGAGTCACCCAAATTCCACAATACCAAAGAAGTATAAGTTACTAGGAG ATTTTTATCAATTTCACTTGAAGAAAAGTTTAGGCAGAGTATCTCCTCAGACTCAAGAGTAAGAGAAATC CTAGTTGGAGTAATTTGAGAACCCAGCAAATCAACTCACCCAAAAAGAATCATCTGATTTTTTACTTTTA AAAAGTACTGCCTCATAGCATATGCAACAGATGATCGGAACAGGTACATTTCATTGTCGTTCCATTCATA CTGCAAATTCAGAAGAAAGACACTGCTCAGAGGGACTCGTAAGACACATTTATAATCTGATACTCCTCAA GAATTATTCTTAATATTCCAGAGATTCTTGCTATTCATTAAGTCAGTGACCTTCAATGTAAGTGTGCATC CGTATCACCTGAAGGGTTAGTTACAACACTGAGTGCTGGGTCCACCCCTAGAGCGTCTGATTCAGGAAGC CCGAGATGAAACCCAATAATTTACATCTCTAACAAACTCCCAGGTGGTGGTAATGCTGCTGGTCAGGCAA CCATGCTTTAGGAACCATTGGGTTCACGGGTCCTTTTACTTTAGTTTGATGTAAACTGAAATTAACACCT TGAGTGTAGGTTTACCGATGGGAGTCAAACAAAAGTTGTGGGTTTTGTAGCAAAATGTCTGTACCTTGTG GACAAAATCAGTTTTTACTATTTTTATGGTACGTTCTCAGAAATGTACTTATCTATAAGTGTAAAAGAAA AACTTGACATTCAAATGAAAAATAACACTTTGTAAACAGCAAGCTAATCTGTTTGTTCTTGTTTTCCAGT GCTAAACAAATAGCTTATGTTTGCATAGCTTTTAAAGACTTAAAAGAAAGCATTCACTCTTTCCTCCAGT AGCTGGCAGTAGGAATCAATGAATGGCACTAGTTGTATGTTTCTCCTTTCCCTTTAAAAAATTATAATAT TTCACAAAAGAATTGTTACATTCACTTCAGCTTGGTTTCACCGAGGTTTAGAGGAGTTCCTTTAATAGTA ATAATATTATTAATATTGTTACTAATAACAGTCTGGCTACTATCTCTATAAATATAAAATATAAAAGATT TTAAAGGCTGAGTTCTCAAAATAATGCCATAGATCCATTGGAATTCACCATGAAATAGTTTGAACTGAGC AGATATTCTGACCCTGTTGTGTAGATGCACTAAATATATGATCTCGTTTCATCAAAACAGATTGTTGCTC AGTGAATTGGCCTCAGAACATTACAGAATCAAACCCCCTGAACACTATTTACCAACCCTCACTGCATGGA AAGAGGATGAGTATAAATGTCAAGAAAAAAGATAATTGAAAATATCCTGATCTGCCGAGACTAATTAAAA TGTATTAAGCCAAGGAAGAGCTAATAAAAATATGACAGAGAAATAGTCCCACAATCACCCAATGATTATT ATGAAATAGGAACTTGAACTCTTAATGATTGGAAAGAAATGCACTTCCATTTTCATTTTTTCTTTCTTGA ATGTTCATCTTTTTACTCCTGAGTTATTTATGTTTTGATGTCTTAACTATGAAAATTATACTAAAAGTGT TATTGAATCTTGGACAATGTTTAACTTTTCAGGAAAGGTAAGGGGGTAGAAACACAATCTTTGGATCTAT CCAATGCAGACAACAATTTGCTGTAGCATCTTGGACCATTTTATCCAATAGTCCCAGATTGACTTCTAAC CCTGCAAAGCCTTCAGGGTGTCATACCCACTCTCAGGCTTTTGAGCCCCATCTACCCGAGACTACTCTTT CCTCTCCTCTTTCCCAATCAAAGCTACCACTTCCTCAGACTGGATCATCTGAGACAGGTGTTAACGACAG AGCAATAGCTAAGTAAATAATTCACATTAAGGTGTAAATAACATAATTTCCTGTAAAATATTTTGTTACC CCCAAAATGCATTTCCCTAAATAAGTGGTTCTCAAACTTTGCTGTGACTAGAATCACCTGGGGAGCTTTA AACACTCTTGATGCCCAACTCTTGACTCCATACCCCAGAACAATTAAATCAGAATCTCTGGAGGTGTATA ACCTAGGCATTAATATTTTTTAAACTTCCCATGTGATTCCACTGTGCAGCCAAGTTTGAGAAGCAGTGTT CTAAATTAGAGCTTCCCAGTCTTGATTGTACGTACAAATCACCTGGAGGCTTGCTAAAATGCAGATTCTG ATTAAGTGGTCCAGGGCTAGGCTTGAAATTACGCATTTTTAACAAGCTTCCAGGTGATTCAAATGCTGCT GGACCATGGGCCACACTCTGAGTGAAGCCAGGATACAGGTGATTGACTAAAACAAAACAAACTAAAAAAA CCTAACTGTACCGCTTCTAAAAACAAACTACCTTTCAAAATATAACCATATTCTCTTTCTAGAATAAAAG TAATGGTGACGAGAGTCAATTGAAAGGATTGGTATCTGATATTTAAGGATTGATACAGATATTTTCTCAT TGAAGTTCATAACACCTTCAAGGCAATAAGAAGTAGGAATAGCTTATCCAATAAGGAATAGGTTACTTTA AAAACCCAAAGCCAAAGGCCAGAATCTGGAACTTATAGTTTTGAAAAGAACCACATGGCCTCTCTTCTTT CAGTTCACACTGAAATGGGTTTATTGTGTCCTATTTAAGTGAAGACTGTGCACTCAAAAATAATCAATTC ACTGTCCAGAATACTCACTGCTTTATCTCCAAGAGCTGATTTTAGGCTTATCCTCACTTTGATGCTTTGG TCTGCATCTGATTAAAGAGAAATAGCAGACTGCTGGTTACAGACAACAGATTGCCCACATGTGCTTATTT CCTTTTCCTCCAAAGATCCCACTAAAGTGATAGTAAAGGGATCTTTTAAAGGTATCAACAGGCTTTTGGA AAACGAGAAATGATGAGACAGGGGTAACTGCTTTCTCAGGGACAGGAAGCCATGACCTAATTTGTACACA GAGGAGGCACAGACCCACAAAGAGCCAAAAAATCCAAAAGAGGTTTGGAATTCAAGCACAGGTGAGGGTG GGAAAATAATACTGGGCTGAAAAGAAGAGGAATGGAAGTCAGGGTGTGGTTAAAACCACTTTGGAGAACA GTTGATCCTCCTACCCCTTGTGCCCCTGCTTGGACAGTCTGTGGGAGGCTATGCTCCAGAAAAACAAGAG GTAATCCAAGAAAGAAGACATGGAATCTAGGAAGCAGTGGATTCAACCCAGGAGAACAACAAATGTTGGG AAAGGAGAATATAAGACTCCAAGAGGGAAGTCTCTAGGGAAAAAAAATGAGACTGAAAAGAATAGATATG TTGAAATATTTGGGAGAAAAACAAATACAACGTAGATAGCAAATTAGGTAAGCCGAAAAATTCAGGCAAG TAGAAACTTTGAGACAAACAACAAGCCACATAAGAAAGGACACAAAATAATACATTACTTGGCTCTTCAG GCATAGTGATGTAAACATTGATAACTGTTTTACTAAAAATCATTATAAGGCCTTATTGGAAGAGCAAGAA ATGGAAGTGGAAGAGTAGACCAAAACGAAGGTTTAAAACTGAGCAATAACAAAATAGCAATATAAGAAAA TTATTTAGAAATATGAAAGTGACTGCCAGAAAGAAGAGATAATAGCATTAAAATTGTTTTAAAAAAAGTA TTTGTCTTTGGAAAGCAGGATTCGAGTACAGTTGGTTGGAGACAGTTATAATATGTATTTTAAAGATGAG ACTAATAAAACAGACTTGAAAGAGTACACACTCTTGTATGTGTATGCACACATGTGCATGCATCTGTGTG TGTTTGTCTGTACAGTTGCTTTCACTATGTCTCATACATAGGTGCTCAACAGTTGTGATTTTTCTCCCAT AAAATGGCAGCTGTCACCATAGCAGAGAAAGAAGCAGGTACTATAGAGAAAGAAACATTCTCAGCTGTGT CACAAGTCCTCATGAGACTGGGGCCAAAGGAGACTAGACGAAGTAGACAAGGAATGGGTGTGAAACTTGT CAACTGGGTGTACTCACATGGACTCCAGTCGGTACTCCATCCCACAAAAGAATTCTTGTTCTGGTCTTTC AGCCAGGTAAATAAGGGCTCAAAGTAGTTGAGCAGTGGCCTTACATTCATGTTCTTTGCTCCTACAACAT TTTCCAATGCTAGGGTCCAGGGTTCTGATTTTCCAAGCCTCAGCATATTGCTACACAAAAAAAGGGGGTT CAGGGCCTTTTGAGGGGTTCCAGATGTACATATATTTACATCTATGATCTATGGTTTCTTCTCTTTGACT TGGCTAAATTTGCTTCTGGCAGATAAGAAAAGAATGCATATTAACAGATATATTCCACCCTAAACCGCTC TTTCCTTCCAATTACCAGGAAGAGAGGGCTGTAGTTATGATAGGGAGAAAAGAGGTGGCCCACCCAATTG TTGTATGGTCTAGGTTCCTGTCTGACCACAAATTAAATGTTTGGTTTGTAAATGAGGACATTTTGAGGCC ATAAAATTTTCTTTTTAGAACAAAGAAATCAAATACAAACCTAGGCATGGAAATGAGTAATACTGAATAC TAGGAGAGGTTCAACATTTTGAGGTATTTCTTACAACAGTTTCTGTCCAGCTTCTGTAGAGTTTGAGATG TCACATTTGTGCAGAGGGCCTTCATGTTTAGCTGCTTGACAAAGTGCTTCTTGAAACTGGAATTGGTAAA GGGTCCTTGTGTAATATCTGCACAGGAGACAAAGCAACAAAAAAGCAGTCCCGTGTTTACTTACTGTCTT AGAGTTATAGATTAGGGCATATATTTAAATCTGGAGCCCAAGTAACCAAAGAGATACTGATCAAATCTCT GAAATCTCTTTCTCCAGACATGAACTCTACACTCATCATAACCTATTTGTGTTTTATGTATCTGTTGATA AACATGGCAATATTACTCTGTTAAATGTTAGCTAACATTTGTTTTGTGTTTTACAGATTAATAGCCCTTT CACATAAATGATGCAAATCCATCCTTATAACAGGTCGATAATATTATTTTCATTTTACAAATAAACTGAG CTCCAGCAAATTCAAGGACTGGGGTTACTAGGTGAAGAACATATGTTTTTGGACTTCAAGTTAAAAATTC TCTATCACAATGTACAATAAACTGCCAGTAACAAGAAGACAAAACTACTTTTTATTTCTCCCAATGATAC TATTGATTGCTGATGACGGGGACAAGATCTTACACAAGTTTAATTTAACCCAATAAATTGTGTTAGTTTA AATTGAATTGAAATTGATCATCTATACAGACAGTTCCCAACTTACAACGGTTGGACTTTTGATTTTTCGA CTTTACAATAGCGCTTTCAGCTGTATATGTTAATGGTAAGTACCCAAAGTTTTTCACTTTCAGCACAGTA TTAAATAATTACATGAGATATTGAACACTTTATTATAAAATAAGGTTTGTGTTAGATGATTTTGCCCAAC AGTAGGCTAATGTGAGTGTTCTGAGCATGTTTAGGGTAGACTAGGCTATGCTTTGGTGTACCATAGGTTA GGTGTATTCAGCGCATTCTTAAGGTATTTTCAACTTATGATGAGTTTATTGGGATGTAACCCCATTGTAA AGCAAGGAGCATCTGTATTGAGCTTGGTAGTTATGGGTGGAAATAGAAAAATTATAATTATCACTTCATT TATCCCTACTTTTTGTCGTTATTAGCACAGCTGTCCACAAACCCTAGAAGTTAAACAGAAACAAGAAAAC TGTAATTTACCGAATGAATGAGTAATCATTAGAAACATGGAACAGAGATGCGGGGTCACAGTATGTTTCA TCATGGGGCACAGGTTCCACCACCCCAACTATCTCTCGCCTTTGGGGAGAAAAGAAAACAATACATTAGC TGTGGATCACCCATCACAAGCATCACAAGCAGGTGGGCATAACTAGTGCAGTTTCATCAATCAAATTTTT TTTTTTTTTTTTTGAGACAGGGTCTCACTCCGTCACCCAGGCTGTAGTGCAGTGGCACGATCTTGGCTCA CTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCCATCTCAGCCTCCCAAGTAGCTTGGTTTATAGGT GTGCACCACCACATCTAACTAATTTGTGTATTTTTAATAGAGACAGGGTTTCACCATGTTGGCCAGGCTG GTCTCGAACTCCTGGCCTCAAGTGATCTGCCCACCTCGGCCTCCCAAAATGCTGGAATTACAGGTGCCAC CGTGTCCAGCCAATCAATGGTATTTACATTAGAAATGGTTGTTGGGTGAAATAGAAACAATGTAAAAAAA AATCACCTACAAAAATAAAAAATAAATAAAAATTTTTAAAAAATCAGACAGTAAAGCTCATTATGTAGTT ATCTCTTAGTTTTAATTAATTCAGCCAGAATATACCCTTGGAAAATAGCTATGTCTTCAAAAGACTAATT TAATAACATTCATAAAGTGCATTGCATGGCCAAAAATGTACAGTGAAAGCCCTAATAATTCCTCTCAGGC ACCACACTTCATGTACTCCTGGCAGAGAGAATTTAATAAAATTGAAATCTTACTTATTCTCCACGCCTAC CTAGCTCAAGTGTTCCCTCCTCTGTGAAGCCTGGCCCTGATCCCATCCACCTTCTGGCAGAATTAACCCC TCAATCTCCTTTAGCCTTCTCTAGTTGTGCCTCCTTTGCCATTTATCTCCCCGTTTTGTAGTTATTCAAC TATAGTAACTTCCTGCCCTAGAGACTTGAGCTCCTAGAGGGTGGGGCTGTGTCTTGGTCTTCTCTCTAAT TCCAGTGTCAAACATGGTGCCTGACACTACAGAAAGAATTAATTTATATTTACTGAACAAAGGAACAATT GATGCATTAATGAATCACTCTAAGGATCTGATTCCATGTGCCTTTAAAATAAGCTAAGAGGGGTCAAAAG ATTAATCCAACCAGAAAAAAAGGTAGCAAAATCATGTATTTGGCTTTGATTAAATGGAATACATTTTTCC TTTAAAATTGCAGGATCATTGTAGACATAACTTCAGTAATATTTAAACACTGGCAACAGTTCTTATAGGT GCTGCGTCTTTCCTCCCAAGTACGATTTATGTTAACAGAGAGAATCTTGACAGAAGAAGTGTACTGTTTT AAACCTGTGCATGTGGAACTGCTTGTTACACATGAGTTCTTCACTTCAAAAAGAAAATATAAGAAAAATA AAGAAAGAAATAATTGACCAGGGTCTATGATGGTAAAAAGAAGATAGATTTCTTTCTTGTTTCCATTCTC TCCCTCCCTCTCTCCTTTCTTTTTTTCCTTCTTTTTCTTTTTCTCTTATAATTCCTTCCTCCAAAAACCT ATTTATTTCATACTTGCATGTGACAGGCACAGTGTGAGGCACTTGTGACACAGCAATAAGTAACGTAGTG CTGCAACCATGGAAATGGTCACTGTTGCCCAAATGTGTCAGGTTCTCTCTAGCTTGGAATTCTCTGTGTT CCCCTCTACACCCACACCTTTCTCAGGGCTTAAATGCCTCTCCTCATCTGACACCCCCAGTTGGGCTTTG GATCTCCCCTGGACGCTAACGGACCCTGTACCCTCCCATCACAACACTACAAATTGCAGTGGTTTAATTT TCCACATCCTGCCATAAACTAAACGTTTTTTGGGGTTGAGGACCATACCTGAAATTATTAACATTGGATC CCCAGTGCTTTGCCTAAAATGTGGGGTCACCGTTTTGTTTAAAAGGCTGGATAAAAGAATATGTAAAATG AATAAATTGATCACTTTCAACATAATATCATAGTTTAATGAGTAAGCCAATACTTAAGAATATAGAGTAT GAAGTAGTGTCACCTGACCCAAGGAAATTTTATCTGAGGAGATGGTATCCAAATGGAGACTAAAATATAA AATATAACAAACTAAAAATACAAAAAGTAGTTAGTTAATGTGTGCCTCTGTGTGTGTGTGTACACGCCAG TCAAATGCTTTTAAATACACAGCAAACTCATTAGAAAACATTTTACTGATTGCATATTCATTGACTTACT TCATCTCCCACCACTTTTTCATCCACTGGTCTTTGGGAATTTCCCCTTTAAAGACCATCCACCTCCACTT CTCTAACATGTAAGTAAATGGCAGAGTCCCAACAATCGTGAGTGCTTGTTTGAGCAGGAAGTTTATTTCT GTTTCTGAAAGTAAAATAGAAAAGGATAAATATTACGATGAAGATGACAGTGGATGTTTTGTGTTAAAGA GAATTTTCCTAACCTCAAAATATTATTCCTCAAGATGTACTTACTATAAGGATACATGAGAAAAATTGAC AGTATTCATAATGATATGTATATATTTATTTTCTCAGCTAAGGGATTTGGAGTAGGTTGAAGCCCTGGAA CAGAACAGGTAAATAAAACCCAAAGTTACTTCTAATCCTCATTTTCTTCATTAGTTTCAGTTTCCTCCCT TAAATACCTCTTATCAGAGTTCATTAGAGCTATTTCATCCACTTTCCCAGTCACACTGTTTATTCTGGAA AGCTCCATGAAGTCAGTGACTGTTAATGTCTCATTTAAGACTGTATAACTTAGTCCCATGTCTGCTACGT GATGCCTTCTGTGAGTCTTTGTTAAATAAACAAATACTAAACAGATTCAGTGAAAAGCCTGTAAACCAGG GAGGGGAAATGAAACAAAAGAGCCCTCCTGGAGGGCACTATCCACTGGATGGTGAAAAGTACAATGTACT TTAAATGTAAGGATATCTTCCTTACCAAGAATTTAAAATGCTTTAACAAATCATGTTATTTCATTTTATC CTTTATTAGTGACATAAAGAGGCAGTGGAGTTCATCTCTAGTGTATGAAGGAAATGCATTGAAATGTAAG CAGGGGATGTTATCTACTTTTCACATCACTGTGTCTCCAGTGTCTAGAAAAATGTCTTGCACACAGTATG TGCTCGATAAATATGTTTGGAAGAAGAAAGAAAGAGAAAGAGGGAGGGAGGAATGGAAGGAATAAAGGAA TTTATTTAACATTATTCACAAATCAGGGGCAGAGTCAAGAAAAAAAGCAGGAGTTTTCCAAACCGGTGGT TTAACCATGTCTAATACTATCTTTTTTATAAAAAAAAACAAAAAAAGCTTTTATTTTAGGTTTAGGGGTA TGTGTCCAGGTTTATTATATAGGTAAACTCGTGTCATGGGGTTTGTTGTACAGATTATTTCATCACTGAT CTAATATCATCTTAAGAAACATAGTCATCAACCATTTTTACCTGCTGTCAGGGAATATTTAAAAATAATA AAATATCTGTTCATTGACTTGAATTAATGATATTTTAAAATTAGGAAGCAGGTATGGTTACTGTTAACTA CCTTTGTTTGTTACTGTCTTCATGGGAGGATGCTGCTACTGGTCTGTAATCCACTAGGACTGTGCTTACA GTAACTATTTCAAACATGATGATAGGCTTTACACTGGCTCACTCCCAGGCCCTTGTGGGATCACCAAGTA TCTGGAACCAGAGATCAAGGCAAAGTGAATTGTCTACTCAAGGATGGAGCTCATGACCTTGACCTCATCG ACCAAATGCTCCAGACAGAGGAGCTGATCTTTATGTCACAAATAACTAAAAATAGGGGAGAGAATATACA GAAGAGAAGAAGGTATTAGGCTCTATTTGTCCTCCATTTATGAGGAAGAATCAAAAGCCATGGCATCCTC ACTGAAGAAATTGGATCTCCTGAACATTTGTCATGTTCCATCAAGTCCAAGGCATCTAAAAGGAAATGGG CTGCCTCAGGCAGAAATGTTGAAGGATAGCACAGATCTAAGGGGATGTTACAGGGGAAATTCACGCTTCA GCAGGATGAACAAAATGTTTCAATCCCTTCTAATCTTGATATTAAACACCTGTTCTTTAAGAATTCCAAA ATTTAAAGCTACACTTTGCTTTGCATAATATTATGGAAAAGACTTTAGATTAGGGCTCTTGTTCTGGTTC CGCCACTACATTGCGTTTTGACTTCGGGCTACTTTCCCTCTCTTGTCTTCAGTTTACTCCTCTATAAAAT GGTTTTTAGAATATATTCCAACTCTAAAGTTTTGGGAAGTTTTTACCTAGAACCAGAGGGGTCTAGTTAG AATGCTGACACTAATTGGACAAGCCATTTCAGTTCTGTGAGACTGTTTCATCATCTTTAAGAAAAAAACT TCTGTTAGATATTTCACAGGATCCCAAGTCCATTCATTCAGTTACCTCTCTTATTCCCTTTTCAATAATA CAAAACCAAAAGTTGACATGTTCTGATATATACTTAAATTTTTTCACCAGTAGTAATTTCCAGTTACCCA TAAATACCTCATACCTTATGTGGCAAAAAGTAAATATTTCCTACATAATAAATACCTTTTCCCATATCAG ATTAAAGAACCTCCAAAACAAGCCATGAGAAAATGTCCATACCATTGTCTTCTTGAAAATCGGGTGACAG AAGACCAATGGATTTTAAATGCTTAGGTGTGGCTGCAGAAAGTGACATGATTTCCCCAACAGCTTCATGG AATCCTTCATTAGCTCCATTTCTTAGCAGAAAAGGTTGTGCAGCATATGCCATATCATACTGGATATGCC CCATCTCATGATGAGCTGTCAGGAAGTCGTCCATTGTCACCTTTGTGCACATAAGGATCCTGCATGAAAA TGGACAAGATGAAAATGAATCTCACTGACTTTCATTTAACCATTACAGTGGAGTTGTATGGGGTTTTGGT AGCATGAATCATCTTTCCAAGATTTATTCACCAGTGAATCTTGAGTACCCACCTCTTATGTCCTAGAGAC AATACTAGTTGCTCAATATAAAGCAATGGGCACAGCTGAATCCTGTTCTCTTGCTCATAGACTAACAGGA AGACAGATAAGCAGAGTTCTCCGCTACAAGAACTCTGAGGCAAGTACTCTATAAGTGATCAGTACACACA GCCTTGAGCGTAAAAATGAGTGAATGTAGGCACAGTTCCCTAGAAGCACCAAGAAGGGCATGACTGAGGA TACAATGAGCAATTTGGACCTTAATCAATGTGCAGGAGTTTGCCCGGTAGATGACATGGAAGTTGACGTT CTAGTGCTCAATGAGAAAGGCTTAGGGGCAGGGGGGTGGAAATGTGGCATTCAGGACACTGCACGCTGTT TGGTATTGCCAGGATAGAGAAATAGTAGAAGGGGCTGCAAATTGAAACTTGGGAATCATTAGCATGTAAG TTGGGAAATAGATATGATGGGCCATGGAACAGGAATAGAATGCAAGAAAAGAGGACCAAAGATAAACCTT TAGAAGGTCCAAGTACCTAAGGAGTGGGGAGAGGAAGATTATTCAGGGGAGACGGAGAAAGTACAATCAG AGAGGTCAAGGAAATCTGGAAAAGAATGACAATGTGGAAGTCGGTTAAAAAAAAAAAGCATTTGAAAGAC AACTTGTAAATCTTGTCTAATGCTGCTATAGCCCAGTGGGATAAGAACTGCATTTGGCAATGAGATGGTG GTCCTTTTTAACTTAGCAAGAGCATTTTCATTCAGATGGGTGTAGGGGTCATACATCAGTAGATTCCTAA ATGTATTTCATACCACTTGGATCATGTCACCACCCCCTCCAATATCCTGCGAGGCCTCCTCATTGCTCAA GAATAAACTCAGCCACCTTTTATACACCAATATGACCCTGTAAACCAAAAACTATTTGAGATAGGTCTCA ATCAATTCACAAGTTTATTTTGCCAAGGTTAAGAACATGCCCAGAAGAAAAGAACACAGAATTTATAGAA ACAGTCTGTGGTTTGTGCCTTTCTCCAAAAATAATTTTGAGGGCTTCAACATTTATAGGAGAAAAGTGAG CTGGAGAGGATAGTGGGAGGGCATGGTAATTCACACATTGCAAGAGAAAGGGGGAAGGTAAGGAAATATT CAGTTATGTATTCATCTCATGCTCAGTAAATCTATTTTCCTTTCACAACCCCAACCTACTTTTCTAATTT GGTTTCTCTCTATTCTCTTTTGAAATAATTATAAAAATAACTACTATATATTTACCGCCTACTGTATGTA AGATTCTGTGCTTGAAAACTTACTTATACTTTCTCATTTTTAAGCCTCACTCTAGTACTGGCATCAGTAA ACTATGGCCTGCTGGCCAGCCATTGTTTTTATAAATAAATTTTTATTGGCACACAGCCACATCCATTGGT TTGTGTATTGTCTATGGCTGTTTTCATGTCACAAAGGCAGAGCTGAGTAGTTGTAACAGAGATCTGCAAA GCTTAAACTATTTACTATCTGGCCCTTTACAGAAAAGGACTGTAGATCCAATCCCTACCCTAGTCAATGC TGGTGCGGGCCTGCCAAGACTTTATCCACCATCCCCTAGCTGCCTGAGTCACAGCTGATAAGGGCCTACA GCTGCTCCCTTCACTGCCTTTGGCTAAATGGGGGTTATGCTCCCCCATACTCTGGGGCAGTCCACAGCCA AAGACTGCCTGATATAAAAGGCTAGCCCCCTTGTCTTGAGGTGTGGCCTAGTCTGTGGCTCAAGTTATGC TCCAGAGAGCTTCATGGGATAAGGCTGAGGCCAAGTTTCCAGTAAAGATCACATTCTTACTTACCTCCCT CCTTTGTCCCAGCCTGCTTCCCTCATTCCCCTCTGCCTCAGAGCTCTCCTCAATGAAGCACTTGTAAAAC GATCTCCTTTTCAAGCTAGGGAATCCAACCTAAGGCTCTCACAAGCCTGCAACCTGGGAATTACTATTCT ACTTTATAAAATAAGGAAACTGAAACCAAAGAAAGTTAAATACCTTGTCCAAGGTTGCATAGTCATTAAG TGACACACCTAGGATTCTGAAGCCTGTGCTCATTCTGCCACATTACACAAACTCTCCTTCACTTATTTCT CATTCTAGCCTAACTTGCCGACTTCAGTATGCAGGTCAGGTCCTGCCTCTCTGTATTTGATCCTGCTGTT CTCACAGCTTGGGTCCTCCTCCCGACTCTGTGTATCTGAATCCTTCTTGTCTTTCCAAACCTAATTCAAA TCCCACTTGTAAAGCACGGTCTGATCCTATCTCCTATTGCAAATGTGGTCAGTTTTCTTCCAGTTCTCCA TAGAGCATGCCCTGTGTCTCTCTTACGACATGTACCACTTTCTCCCTTCGATCCAAGCGTATTTATTCAC CTATTCTGTCTCATTCACAAGAGTGAAACATGGAGGGGAAGATCAATGTGTGATTCATATGTCCATCTTC CAAAAATCTTAGCACCAAATCTTTCCTGATATGGGTGCAACCATCCCCATTACCATACAACGCCAATGGA TGCATGATATTTCCAAGAAAGCAGATTGTCCACAGGTTCAAGTTAGAGCCTGCTGGCAATCCTCTTTTCC TGGGAAAACCCAAATGTGCTCTCCTGGACTCCCAGCCTTAGTTCAAGGAGAATTAACTTATCTTTTCTGT GCTCAGAAAAGCAGAGAAAGAATTCAAGTTAAACTTCAGCCTGCCTCTGTTGTCTCCCATTTAGTATCAG TTGTGTAAGTATCAGCCCCACTACCTGAAGTCGCCCTTCCCCAGGTCCCAAGCTGTGGGATGGCAGACTG CTTTCTGAACATTTCCTGGGTCCGTTAGCATGGAATTTTCCCAGAATCCTTGAGTCATATTAGGAAGACC AACAGATACAAAGAACTTCTCGGCCTCCTTGAATATTCTCTGTGCATCCCAGGCCTGGGAAAAGAGAACA GTATTAATTCCAGCATCAAAACAACAGCATTCTTAAATTAAATAAGCCAGGCACCGAAAAACAAATACCA CATGTTCTCACTTATGTGTGGAATCTAAAACAATGGAACTGGTAGAAGCAGAGAGTAGAATGGTGGTTAC AGAGGCTATGGGGTGGGGGCAACGGGGAGATGATGGTCAAAGCGTACAAAGTCTCAAACAGGATGAATAA GTTGGTTTTATTTTTTTGAGATCTACTGCACAGCATAGTAAATATAGTTAATAATAGAACATTGTACATT TTGAAATTGCTAAGAGAGTAAATTTCAAATGTTCTCACTGCAAAAAAAGTATGTGAAGTAATTGATATGT TAATTAGCTTTATTTATTTTTCATTGTATTCATAAATCATGAAATCACCTTGTACCCCATAAATATATAC AATAATAAATGTCAATTTACAATAAAATTTTAAAATGGAAAAAAGTGCTAATGTCATTTTTAAAATAGCA GCATTATTTCTGTTGGATATATACATTGGCATAACCTTTCCAAAAGGTAATTTGATAACACACACGGATA GCATTTGAAATTCTTCTCTTTGTCTCAGTAATGCTGTCTCTAAGGAACTAACCTAAAAAATTATCAGAAA TTAGATTCAACAATTACATTGAGAATTATTTTTAATAGAGAAAAAGTTGAAACGAACATCAGAATGGTTA AATAAATAATGATACCTTTGAAAAATAGAATAATGTGCAGCCACCCAAATTATATTTATGAAAAATTTTT TGGTTTATATCCAAAAGACAGGCAATAACAAATGCTGATGAGGGTGTGGAGAAAAGGGAACCCTCCTACA CTGTTGGAAGGAATGTAAGTTAGTACAACCACTATGGAAAACAGTTTGGAGGTTCCTCAAAAAAGTAAAA ATAGAGCTACCATATGATCCAACAATTCCACTGCTGGGTATATACCCAAAAGAAAGGAAATCAGTATTTT GAAGAGATATCTGCACTCCCATGTTTGTTGCAGCACTATTCACAATAACCAAGATTTGGAAACAACCTAA GTGTCCATCAGTAGATGAATGGATAAAGAAAATGTGGTACACATACAAATTGGAATACTATTCAGCCATA AAAAAACGAAATCCTGCCATTTGCAACAACGTAGATGGAACCGAAGGTCATTATATTAAGTGAAATAAGC CAGGCACAGAAAGACAAACATTACTTGTTCTCACTTATTTATGGCATCTAAAAATCAAAAGAGTTGAACT CATGGACATACAGAGTGGAAGGATGGTTACCAGAGGCTGGAAAGAGTAGTGGGAAGGTGGCAGGGGCAGG TGAGGATGGTTAATTGGTACAAAAAAAACAGAAAGAATGAGGCTGTGTGATTTGTGACTTTGGGCAAATC ATTTACCTGAGCCTCAGTTTCCTCACCTATAGCATGGAGCTGTCACAATACCTATCCTGAGTCAGAGATG ACAATAGAAGAGACGGGTGTAAAAACCCTTTAGAAAGACTAAAAATCTACATCAAGATGGCCCTATACTG CTGCTCAACTTCAAAGTGGAGCTACAACAGCTACAAGAGTTTAGAGGCCCTTGCAGTTTCACTTTTTATT CTGCAGTGGACTTTTCCCAGGAGTATGTTATGTATGTGAAGATGTTCATTGCATTGCTTCTTACAGATGT AAAACTATTAACAAGCAAAGGTTCAGCAATGCACAAATAGTAAATTATGGTGCAATTATCTGAAGAAATT TTATAAGGCAAATAGAAATATGATTAGATATTCTACTCAGAAACGTAGAATTTTAGTTGAATGAACAAAT ATACATAATTATAACTATAATACCATTTCATCAACAGAAGGGAACACAGAGAATTTTTTTTTTTGAGACA GAGTCTCACTTTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCTGCCTCCCG AGTTCAAGTGATTCTCCTGCCTCAGCCTCCTAAATAGCTGGGACTACAGGCGCACACCACTATGCCCAGC TAATTTTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAT CTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGCTGTGAGCCACCGTGCC CGGCCTGATAATTTTTTAATTTTAATTTTAATTTTAATTTTAAATTCAGGGAGTACATGTGCAGGTTTGT TACAAGGGTATATTGTGTGATACTGACGTTGGGTTTCTATTGGTCCTATCAACCAGATATGAACATAGTA CTCAATAGGAAGGTTTGTACTTCTGTGGGATCAGTTGCAATGTCACCTTTGTCATTTCTGATTGTGCTTA TTTGGATCTTCTCTCTTTCTCTGTTAATCTAGCTAGAGGTCTTTCCATCTTGTTTATCCTTTTAAAAAAC TGACTTTTCATTTTGTTGATCCTTTGTATGATTTTTTAGGTCTCAATTTCATTAATTCTGCCCTGATTTT AGTTATCTCTTTTTTTCTAGCTTTGGAACTAGTTTGTTCTTGTTTTTCTAGTTCCTTTAAGTGTGGTGTT AGATTATTAATTTGATATCTTTCTAGGTTCTTGATGTAGGCATTTAGCACTATAAACATTCCTCTTAACA TTGCTTTTGCCACATCCCAGATATGTTGTTGGTATGCTGTGTCTCTGTTTTCATTTGTTTCAAAGAATTT TTTGATATCTGCCTTAATTTCATTGTTTACTCAAAAGTCATTCAGCAATAAGTTGTTCAGTTTCCAGGTT ATTTCATGGTTTTGAGAGTTCCTCCTGGTATTGATTTCTATTTTTATTCTACTGTGGTCTGAGAATATGT TTGGCATAATTTTAATTTTTTGAATTTATTAAGACTTGCTTTATGACTGAGCATGTTGCCAGTCTTAGAG TATGTTTCGTATACAGATGAGAAGAATGTATATTCCATAGCTGTTGGGTGGAATATTCTATAGATGTCTC TTAGGTTCAATTGGTCAAGTGTCAAGTTTAAGTCCAGAATTTCCAGAATTTCTTTGTTAGTTTTCTGCCT CAATGATCTGTATAACACTGTCAGTGGGGTGATGAAGTCCCCCACTATTATTTTCTGGATGTCTAAGTCT TTTCCTAGGTCTAAAAGTGCTATGTTTATGAATCTGGATACTCCAATGTTGGGTGCATATATATTTAGGA TAATTAAGTCTTCTTGTTAAATTGAACCCTTTATCATTATGTAATGACCCTCTTTGTCCTTTTTTACTGT TGTTGGTTTAAAGTCTGTTTTATCTGATACAAGAATAGCAGCCCCCTGCTCTTTTTTGTTTTCTATTTGC ATGATAGATCTTTCTGCATCACTTTACTTTGAGCCCATGGGTGTCATTACACGTGAGATGAATCTCGAAG ACAGTAGAAGGTTAGGTTTTGTTTTTCTCTCCAATTTGCCACTCTCTGTCTGTTAGGTGAAGCGTTCCTG TCATGCTGTTGTTAGCTGGTTGCTTTGTAGTCTCGATTGTGTAGTTGCTTTATTGGGTCCATGGGCTATG TACTTACTTGTGTTTTGAGGAACCTAGCACATTTAAATAATTAAACCAAAGTAGTAATAAAGATGTTACT TAAAATTGTTTTAAAGATTCTTGTAATATTTTTAACACTAATAATTTTTTAAATATGCAAAAATCCCCTC ATAATATTCTTGTTTTTACTATCCATAGAGATTACTGGCTGGTTACTTAGCAATGACAAACTTTGGAATG AGTGATACCAACCAGTTGACAATTCTACATCTTACCGCTTAATGGAAAACTCAGGTAATCTCCATTTCAA ATACCTTTCAATGAGATCAATACTACACCTGCAATTCAAGTTATCTGAGGCCATTGTAAACTGCTTTTCC ATGAAACTATAGCTACATAAGAAATAAATTTCAATTAGCTTAAATTTTTTATTTACATGGTTTCACATAA AAATAAAAATAGAAGGATGACATAAAAATAAATGAAGTTGAGAATTTAGATTTAGTTTTTAAGGGCTCTT TTTCCTACCTGGTCCACCATTGCATCAGTAACATCTATGTTTGGTTTCTGTCCAAAGGGAACTGTCAAAG AGTACAGATTTGTCCAAAATCTACCCCACATATCACCTATATTTAAAAAAGAATCTGTTAGTATATGACA ACACAGCAGAAATGTAGACATAATTTATTAAATATATGGACCATCATTGACACTGTAAATTAGAAAGAGA TTTCTATAATCTACCATCCATGGTACAAAATATTACAAATTAAGCTGTTAGTAATTCCTAGTGTTGGCTT CAAAAGAGATCATATAAGATCATCATTCAGGAACTTCTACTAACTGGTAACTAAATTCCACTTTTATTCC TATATTCGTGTACTTAACTTGGTGACTTTGTAAACATCTCAAACAAATGTTAAGTTGTATTCCAAGGCCA GGGACCATAAAAAAGAAGATGTATCTAGAAAAAGTCAATCCAAGAGCAGGACCAGAATCCTGGTGCCAAA AAAATGGGGCAACAAACTTCATGAAGAGTACTCCTGTAATCCCAGCACTTTGCAGAGCTGAAGCAGGCAG ATCACTTGAGATCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAGCCCTGTCTCTACTAAAAATACA AAAATTAGCTGGGCATGGCGGCTTGAGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGC TTGAACCCAGGAGGCAGAGGTTGCGGTGAGCTGAGATCAGCCACTGCACTCCAGCCTAGGCGACAGAGCG AGACTCTGAAAAAAATAAAAGTACTCCCTAAACTTATATTTTAAAACATAAAATTTAGTAGTGATACATG TGAAGTCCTATGCTTAAATTTTAAAGAAAAACCTATCCATCATAAAAACATATATGTGACATCAGGCTAA AGCACAGTCCACATGTAAAAGACCAAAAATGAGCCAACAAACAGTATGACCTGGCTTCTAAAGCATAAAT GTGAACTTGAGCTAAATCAATAGAAGTATAGTGTCTAGAACAAAGGTAGTCATGGTACCATGTCTTTCTT TATGTTGGTCAAACCTCATCTGGAGTAACTGTTCATCTCTAAGCATGATAATTGAGGAGGGACATTGACA AAGTACAGCTCATTGAAAGGAGAACAATTATAGAAAAGTGAGGTTTTAAGGAATGGTTGATAATGTATAA GATATTTAACTTGACAAAAGAAAATAGGGTAAACATGACAATAACAATAATAGTCACTAAAATGTATTGC ACCAGGTACTATGCTGTATCTTATATGATGGTTCTTTATGAATATCTGGAAGGTCATCTTGTAGAATAGG AATTGACATTCTGGGTAACCTCATAGCATGGAAATAGGGCTAATGAATGGAAGGCATCAGAGGGGTGTTG CTTAAGTTCCACATAAGGTAGAATTGTATTACATTGGTTCCATGTAGCAGTAAATTAGTCTATATTGGAA TGAAGAAATTATCCCATCACACCAGACAGGTTTAAGCAGAAACTGAATTACTAAATAATGCTTGCCATTG ACATTGTAGGAAGGATTTCCATATTACTTTAGAGTTAAAAGCCTCCACAGGTCCTTTCTCCGCATTCTCT CCTGCTGACAGACACGAGGTATGGCTGTGGAGGAGATTAGCTTCCAGCAACTTAGTTTGACTACAGTAGA AATGCTATATATGCATGGCATGAAATTTTCAAATATTTATATTTTATTTGGCCTCAGCTGCTGCGGTGGG AGAGGGGAAGATGGTCACTTTCATTCATTCTTCACTTATACGATTCCAAGCCAAGCACTTTTCAGCAAGA GTAATTGGTGAAGTCTAGAATGAACTTAGGAAGCTTTCGCTCAAGCTATAACCTTCTGTTACCCCTGACC ACCCCCAGCCAACCAAGCTCTGACAATATGATACTAAAATCTCAAATTCCACCTTAAGAGCTTAGCCAAT CAACTTGAATACTAAAAATTATTTTCCCCATTTCCACTCTCATTTGAGCCTGTAATTCTTTCTCTAGTTA TCTTAAATAACCCCTTTATCATTTGAATTGCAGCCAAAATAATAACTCTTTATGTACAAAAAAAGTAATA CAATAGAGAATTGTTTAAAATAGACTTTTGGTTGAAGAAAATGCTTTCAAAATGCGATTTCTACAATGTT ACTAACCACTTACAGAATTTTTCAAAAGTTTTATGTTAAGGCTCACTCAAAAAGGCAATTTTATTGTTAG AAATAACAAAGAGCCAAGTACACGAAGAATTCATGGGGCTTCTTACCAAGCAAATGAGCAGGGAGGCATC CAATTGGACTGATATAGGAAGGATAGGCATTCATCAACTTTGCCCTCACATAGGCATGAAGATGTTCATA TAATGGTTTAATCTGAAAAGCCCAGGAAGAAAGTTTAAGACAAAGAGTAACCAATTCTAATTTCCATTCC ACAACACTAGAAATAGGAGATTCTTTAAACAAGTAGAATTTCCCCAAATTATAATTCTTCTTCTCTCAAA TTTCTGGAAAATTTAAAAGTATTCCTTCTTCCTAGAACTTGATGATAACTCCACTGCATAAACCAATAAA CATACTTGGGAGAACACAGGTCCCAAAATAAAAGCAGATGCAAAAAATATATATTCATTTTTAAGATTGT TACCTACTTCCTTTGTTTTTACATTGAGGTATAATTTACATACTATAAAAGCCACCCATTTTCAAGTGTG TAGTTCCATGAGTTTCAATAAATTAAAACTACCGGGAAACCATCACCACTATCTAGTTTTTTAATATTTC TATAACCACAAAAGGTTTCTTGTAGTCAGTTCCACTCCTATCTCCGGCTACTTTGAGTATATCAGAGTCT GTTTATTCATTCACTAGTTGAAGGACAGCTGGGTTTTCCAGTTTGGGGCTATTATGAATATTGCTGCTAT GAACATTTGTGTATGTCTTTCTATGGATAAGGACACATGTTTTCATTTATTTCATATAGAAACCTAAGAG TCATGGTAAGTGTGTGTTTAACTTTTTAAGAAATCGCCAAACTGTTTTCCAAAGTGACTGCCCCATTTTA CATTTCTTCCTGCACTGTAAGAGGGCTCCAGTGTCTCCACATTCTCCCCAATACTTGGTATTGTCCATCT TTTTAATCATAGCTATCCTGGTGGGTGTGGAGTGGATTTTCATCATAGCTTTAATTTGCATTTCCCTAAT AACTTTTTATTTGCCTATTTGCCATTTGTGTAATTTCTTTGATGATGTACTTATTCAAGTCTTCTTCCCA TTTCCTTTTTGGGGAGTTGTTTGTCTTACTTCCATTTTTGATAGCTCTGCCAAACTATGGCTGTGACAAG GTAACTCACATCAGAAGTTTGAAGGTTCACGTAAAGGGGAGGCATGGGGCCAAAATGAAGGAAAAACATC CATGGGACATTTCTGTTCACAAAACTCTCTCTTCCCTATGAAGACTAGCTTACTCAAAGTAATAGTATCA ATTGTCCTGAGGAAGAAAGCAAAGTCCATAGCTCTGCTAACACAGGAAGACAGTGCCAGCCCCAGGTAGC TCAAGAAGATCATTCCTACTTATAATCTAAAGGACCATTTGTTCTTATAATATTTCATTCTTATAGTCTT TCTATTGGTAATTAATGGTCAGTGACTGAAAGAAGGAGGAAAGCAGCGCAATTCTGATCATCTGTAGGGG CTGTCCTATTATTCTCTAAAATCTTTCAAACTCTAATATTCCATAACTTTATGAGGCCTGGGAATGGCTG ACCAATGTGTTAAGAATGAGCCAGAATGCCTTTAGTCACTGTCCCTCTTTCCCATACACTGCCCCACAAC TGTTTGTGTGTACAGTTCCTTGCTTACCTCTTCAAAGGTATGTTCCACATCTTCAATCAACTGGCCGCGG CTGTAGTCATAGCCATCTACCCCATTTACTTCATAGTCTCCTCTCCAATAATCCCCATAGTCCTCATAAT CTGTTTGTTTTTTTTTTTAAAGAGAAAGGGAAGAACATAAGGGAAAGAAAGAGAGAAAGCACAAAATACA TAGATTAGCCTTGCTGGGAGGTTAAAAGAAATTTAAAGGCTTATCACATTTTTATTGTGATAAACATCAA CTCAAAGGGATGCAAATGAATAATAACATTAAGTAATCTCTGTTTAAGCACTTGCTCTGTGCCAGGAGTT TAAATGTATTATTTTATTTAATAAGCACAAGAACCATACAAGATTGTCATTATTATAACTCCCACTGTGC AGAGTAACAGCCTATGTTTATTTTTAAATAAATTTTATTGTGTATATTTAAGGTGTACAACATGATGTTA TGAGATACTTATATAATAAAATGGTTACTATAGTAAAACAAATTAACATATCCATCATCTCACATAGTTA AGCATTATCCCCCCCATGGAAGAGCAGCTAAAATCTACTCATTTTGCAAAAATCCTGAATACAAAACATT ATTACTAACTACAGTCCTTATGTTGTACATTAGATCTTTAGACTTGTTCATCCTGCATATCTGCTACTTT GTATCCTTTAACCCACTTCTCCCCATATCCCACCCCGCTCCACCTCACCCCTGGTAATCACTATTACTCT ATCTCTGTATATTTGATTTTTTTGTAGAATCCACTTTTGAGTGAGATGATGCCATATTTTTCTTTTTATG TCTGGATTATTTCACTTAGCATAATGTCCTCCAGGTCTATCCATGTTGAGGCAAATGACAGGATCTCCTC TTTTTTAAGGCTGAATAATATCCCATTCCATATACCCACCACGGTTTCTTTATTCATTCATCCCTTGACA AACACTTAGGTTGTTTCCCTATCTTGGCTATTGCGAATAATGCTGCAGTGAACATGGCAGTGTAGATATC TTTATGAAGTGGTAATTTCATCTAATTTAGGTATATACCCAGAAGAGGGATTGCTGGATCATACGGTAAT TCTATTTTTAATTTATTTAGGAATCCTCATACTATTTTTCCATAACAGCTTCACCAGTTTATATTCCCAC CAACAACCTGTGCTTAGAGTGGTTAAATCACTTGTCCAAGATCACACAGCTGGTAAGCGAAAGAAGCACA TTCCTAGTCTCTTAACCCTGGGTGTGTACTCTCTTGATACATCAGTTTGTATCTTTAGCTTTAAAATATG TGACTGGATCTCTAAGTTTTTAAATTCTTCTTTTGTTCATGGCCTTTTATTTTTAGATCAGACCCAACTC ATCTTAGACTTTGCCACAGTGAACCTGTGTTTGTTTGCAAATTATATGTATCAATAGCATGTTTCTATGT GCTTCCTTTAGTATCTCACCATCAGAAAACACAAGCTTGTGTCAGGATATTAGCTAATAAAGTTTGTAAA CATAATTTAATAATTTTTATTTTTACATTCACATTGGCAATTAATGATCAGGAAGATGAGGAGAGAAATA AATATTTGGATGAAAGGACATGCAGGATATTGTTTTAAAAATGGTGATAAGCTATTGTCTCCAGCTTGCC TAAGGCTTAAGAATACTGAATTTAAGTGGCAGTGAAAGAAATGTTAAAACAACAAATGCGGGAAAAAAAT TCTTCCTTACTCAACCTCAGTGGGCAGTAAATCATCAAAGCAAAATGTGAATCATGATTCCATGACTTCA GCTCACTATTCAGGGAAGAGAATAAGTTAAGAGATATGGAAATTCCTTCCTATGTTAAGATTTTTTATGA CCACATAATCTGAGATATAATTACAACTGCAGAAAATAATACATTTCCAGCCTAAACTAATCTGATATTT TTTCTTTCTGGGGTATCACCCTAAGGTAGACACACAAATGACCTTTGAAAGTGAACTGTGGGGGCTTTAG ACAAAAGGCAGTGACTCTGTCTTTCATCCTGAGAAATGGGATTCCCCCCCTTAATCCCCAGACTCCCTCG GGAACTTTTAGGGGCCTGAGATCTTCCTAGATTACTTATAATTCATAATTCCTGGATAATTTACTTTAGG CCTTGTAGTTGAGTCTCATTCTTGAGCTTCTTGAATTGTAGAATGCCAGTGCACCTTTTCTTTTTCCCCA GTAATTTCTTTTGAAAACAGGTAATCTGAATTGTTGAGGACATGATTGTTAATTGAGGGGTATCCCTGAT ATCAAAGGGCAGGCTTGGTAATGCAGAAGAAATAGCCCCGTGGCCACACAGAGAGCTTCAGGACCTCTAC AGATCAGCAAACTTACGATTTGCTCTTGCCATCTCATTTTTCAAGACCACATACTCTTCATATAATGGCC TCAGCTGCTTGCCGACCTCAGATCTCCAGCTTTCCCAAGCCCAGAGCCTCTCATTGTAGTCTAAACTGTT TGCCATTATTTCATTCAAACCTGTTATCCCAAAGCACACAAAGACAAGAAAAGATGCCTTTGTAAAAATT TTATTTGTAAAGAACTACATGAACTTTAAAGAATTAAAAGTAAGGTTGGCAGACATCAGGTCATAAAGTG GTTAAATAAAATCTCATGATTCATTCATGTCCTTGCCCTTATAGTTCCAAAATATGTCTGCAGAGAAAAT AAACCACTGAAATGACTTACTTACTGACTTGATCAAATTAAGTAAATGTGATACAATTTACAAGAAAGTT TTACTAAAAGTTAAAAGAGCATCTATGTGTTGAAACACACATATCTGCAATCATTTTTAAAATCTGAGAG AAAAGTAAATTTCATAATCACTACTAAAAATTAGTAGCCTACCTGGTTCAAGTAATAAGCATTCTTGTGG ATTATCTGGGTTACAAACTTTTCCAGTACTGTAGATGGTGCTCATTGTATTTAGAATTGTGTTCAACTGC AAATTAAAGATAATAAACAATGTTAACAATGGAAATTTTGCTGAAGAGAATGCTAATATAAAGATATCCT TTTGACCACATGATTTTTTGATTACTCAAAATACAGCAATTTACTTCTTTGCCATGTATCTTTCTGTATG TGGAGAAGGAATAGCCCAGTTAAGTTTCCCCACTGTCGACTAGCACAAAGTACTATAAGCACATAATAAA TATATATGGAGTAATTGAAATAACCAGATCTACCAAAACCCAAAGAAGTTTTCTTATCCACACATACACA GAGAGGTGCATTTTTTGTTTCATTCAGCATTTATTGAACCTGGAATATGTCCTACACTCTGACAATTCTG AAGTGAACAAGTCAAAGACCATAAAGTCATAGGACAGTGAGGCAGCCATGAAATCAATAACTATTAATAC ATAACAGAATGACAAGTGCTATAACTGTCACCAAAAAGTGATGCGGTAGTATAGGAGCAGGGAGAAATTA ATAACTAATAACCAGGAGATTCAAGAATGGGTCCAAAGAGAAGGGAAGATAAGAGCTGTGTCTTGGAGAA GAAGTAGGCACTGGTCATGTAGAGAAGGGAGGTAGAGGGAAGAGTCTAAAAGATGGAAGGAGGTTGGAAA AGACAAGGCATTCTCAGGGGACAGTGAGATGTTGAATGAAACTGGAGCAATGGTGTTCATTAGGGGAAAT GAAAGACATGAGAATGGAGAGACAAGCAGGGGCCAGATCACGAGGGACCGTCTATGCCATACCAAAGTTT TTAAACTTTACCCTGCAGATAAAGTGAAGGTGATATAGTGAAGCAGTGCTACTCCAGGTGTAATCCGTGG ACCAGTGCAAGTGACAGTTTGTTTCCATTCTGTGATAAGTACAGGAATTAAGAGAATAAAAGTTTATAAA CTTTGGAGAACAATTTGATATTTCCATGACATCTAAGCATGTAATCAATGAACTTAAGCAAGTATTGATC TGCAATGTATTGGAAATAAAGGAATAAAGGAGGGAGAAAGGAAAGACGGGAGGGAGGAGAGAAGGAGGGA AGGAAGAAGAGAAGAAAGGAAGGAAGGAAGGAAGGAAATGGTTCTCTCCCTCAGATTGATTTAAGAAGCA CTGGATTAAAGGATCTGTTTCTCCTTCTCCTATTTCCCTTTGGTTCTGCCTTGAGAGTCATCCTAAAACA TGAAATAGATCCTATGTTTAAAACTTCCACACGATCCCATAGTCCAAAGGAACAAACCTAAATTCCTTAC CATGGCACAAAACCCCTCATGGTCTCTCTCCAGCTCTTCTTCAATCTCCACGGCTTCCTCTCCATCAAAT CTAAGCAACCTTGAGTCCCTCCTCTTCCCAAACACTTTAAGCTCTTACATGCATTTCAGTGGTTTTCAGT CCTGGCTACACATTAGAATTATCTGGGGATTTTTTAAAAAATAGAATTTCTAGGTTCCACCTAGGCTAGA CCAGATTGTCTATATGCGAATGGGCAAGGTTTCTTATAGTGTCCTTGTTGGGGGAAAAAATGGAGAAACA TAGAATGGATAAAGTAAAGTGCATTGATAATTAGTTGGATAATTGGACCCAAAGAATGCAGAAAAATAAA TGTTAACTTGTAGAAAGATACATTTCACATGGTTTTATCTTTGCCTTTTTGATGCATTTTTATTTTTATA TTCACAGATTAGAACATACAAAGTTCCAGAGGACAAGCAACTGAGAAAGAAGACTTTCTTTTTAAATAGC TAAATATTTTAGGTTAAAAATATTTCAATAGGCTATATCAGAGGTCTGCAAACTGTGTTCTGCAGACCAA ATCCTGTCTGCTGCCTGTTTTTGTAAAGTTTTATTTGAACACAGCCATACTTGTTCATTTATATATTAGC TACAGCTGATTTCCTGATACAACAGCACAGTTGACTAGTTGCAACACAGACAATACCTAAATACACAAAA CCTAAAATATTTACTGTCATCTGTTCCTTTACAGAAAAAAAAGTTTGCTGTTGACATTGTGGACAAGATC ATTCTTTGTTGTTGGGGGCCATCCCATGCATTGTGAAATGTTCTGCAGCATCCCTACCCACTAGATGTCA ACAGTATCCCCATTTGTGGCAACCAAAAACGTCTCCAGACATTGTCAAATATCCCCGGAGGGCTAAATCA CCCCCAGTTGAGAACCACTGACATAAACTAACTGTATTCTTCAGGCTGCCTGATCCTTCAGGAAGGTGAC CTAACACTAGGGGGTGTCCATACACACCACAGTGCCAGGGACAATCTCAGTTTAACTCTGTGTTTGAATA TAATAATTACCAGTGTCTTTCACTCTCAAAGATTCCAGTTTGAATAATAAATTATATGGACACCTTACCT AGGCATAGAGAGAGATTTTTCTAACATCAGCATTACTATTTTTTCAAATAAAGGCAGCTGCTGTGGGTGA TATTAATGTTTAATATTTCCCAAATATTTCAACTCTTGGGATCAATGCTAAAATGTTCACAAACGTACCC GTTTGCTCTTGTCTTCTGAGAGCACTGAAGACCCATTTTGCTGAAGAGCCTGCAGCTGAAGCTTGACTGT GAGATTCTGAATTTCTTGTAGTGGATACATTTGGGCAAGTGTGGACTGTTCCTTTAAAAAGGCAGACCAT TTGTCCCCAGCATTATTCTGAAATGACAGAAAAGAAAATTGAAGTTGGAATGGCATTGCTTGAAGAGATA GAACAGAAGATATAGTCCAAATAATATCTGGTGAAACATTTAATATTTCCTGAGTGATTTAGTCCTCTAC TCCGCTGAAGGTCAAGGTTTAGGTTAAGAGTGACCAGGCCACTTTTGACCACTCTCTCTCTCTCTGTCTC TCTCTGGCCTATTGCCTGGTTTTCCCAAGGGTCTTGTCCCCAGAACTGGAAATGAATTCTCACAGATAAT CCACATTGTGGGGCCCTGGAATTTATAGCCTTAGTGCTGTGACATAGATGAGTTGGCCAAGAATTCAAAG ACGAGTGCTCTAAAAAGAGAATCCAGTAGAGCTCAGAGTGGACTTAATGAGAATACAGCCCCCTAATAAC AATGGAAACCATAAGAAATGAGAACCGGTTCACAGTAACCTCCTAGCTGCCGTGACTTAGCCCAGGGATT TTGATCTTAAGTTAGGATTCCCAAAAAAGGCTTCCCAGAAAATGGCCATTGGTAGCCATGGTGATTTTCT ACCAGCAAAAGAAATCATCAAGCAAGTGATGATGCCAGGACACATTTCCCCCCCTCCTGAATCTTGAACA TCAGTTGGAAAGTGGACTTCTCCAAACTACTGTAGTGTAGTCTTTTCTCAACTTACAAATTCATTTCCAT TTACCAAAGACCAAAATGAGCAACTACTTGGTATATTGTACTGCCCTAGACCACACAAAAGAGATAACGT TTGAGGAAAGTAAGAATTCTGCTCCTGGACTCAAGTACCTTAGCCTCTCTGAGCCACAGTTGTCTTATCT GCAAAATGAAAGTAATAATAGGACTTACCTCCAAGGACTGTTGTAAGGATTTGAAGAAGTAACAAAAAAA TGAAATGCTTACAAGAGTGCCTAACACATCCTAATCATTCAACAAATGTTAGTTATTTTATTATTTATTT ATTATTTATTATGTTATGATTTATTTTATATTTTGTTATGTATAGGGGAAAAGTCGTTGTCCTTAGATTG CTTTCCATTTTATCAGACAGATAAGATATGCATTATAAATGTTTCATTAATGAAACATAAGAGTATATAA TAATGTATAAATTATGAGTGGGCCAAGCAGTTTCTGTTACAAGAAAGAGGAAATTCATGCAGGTGACCAT ACTTGGCCAAGCCCTCATGCAGAAGTTGCAACTTAAGACAGACCTGAAAGTAGGTAGGAGTCAGATGAGT AGAGAATACTTTGCAAAATAATTTACCTCATTTGATTTTCTTAACAACACTATGAGGTAGAAAATCACTC TCTCTCCTTTTTTGTACATACAGAAAGCGGCTGAGAGAAATAAACAGTGGAGCTGGCAATCAGCCACCAG CATTTGATCCTGGCCCTGTGGCAGACAGACTCTAAGAATGCTCCCATGATCTCTGCCTTTGGTGGTCACA CCCTTGTGTGATCCCCTCCCCATAAGTATGAGCAGACCCGTGATTTACTTTCAACCAATAGCATACAACA CAGGTGACAGGATGTCATGTTTACGTTACATAAGATTTTAACTTTAATCTTGATAGAAGACTCTCTCCTT TGCTGACTTGTTGCAGCAAGATGCCACGTTGTGAGCTACCCTATGGAAAAGGCCACATGGCAAATAATTA AAGACGGCCTCTGAGTAATTGCATTGGCTTGGAAGTATATCCATCCCCAGTCAAGCCTCAGAAGAGACCA TAGCTCTAGCCAGCACCTTGAATGCAACCATATGAGACTTAGAAGCAGAAGATCCAGCTGAACTGTGCCT GGACTCCTAGCCCACAGATACTGTGGGATATTAAATATGTGTTGTTTTAATCTGCTAAGCTTGTGGTAAC TTTTTACACAATAGATAACTAGTACAGCTCCCACAGGTAGAACTTCAGGCATGATTGCACTTTCCAGGCC AAGGAATTTCACTTTTACCCTCTGAGAATTAGGCAGTCACTGAGGGTTTTGACTACGCATGTGACATGAT GGAAATGGTGCACAGAAGTGGCAGTAATGAGCCACACAAGAGACAGAGAAAATAATGGCAGTGAAAATGG AAAATAGGCTGTGTGTAGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGAAGATCGC TTGAGCCCAGAAGTTTGAGACAAGCCTGGGCAACAAGGCGAGACCCCATCTCTGCAAATAATACAAAAAC TAGCCAGGTGTGGTGGCTCGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAAGATTGCCTGAG CTTGGGGAAGTCGAGGCGCAGTGAGCCATGATCACGCCACTGCACTCCAGCCTGAATGACAGAATGAGAA TCTGTCTCAAAAAAAAAAAAAAAGGAAAGCAATTTCTTTCTTTACTGAACACTCACAACCTCTCAGAAAC TGCTTTTTCATTAATCTTCACAACAACCTTGTGAGGGAGTTGTTATTGTCTCAACTTTACAAATAAGGGA AATGAGGCACACAGCAGGTAACTTTCCCTAGGTCACACAGCTAGAAATTAGAAGAACCAGGGCATCAACC TAGTGTTTACTTCCGAAGCTAATGCTCTGAACTATTATCCTATAGGTTGTATTTGACACATTCTAGTCTT CTCTCTAACATGCAGGAGTGGGAAGAAGTGAGCTATGGGAAGAGGAGTTTGGTCTGCAGCACAAACTCAT CTATGCAACCCACCTGACTCACTTCTCAATCCCTACCTGGCTTCACCCAATCCAGATGATTTACTGTGAA GCAAAATTTCTGGTAAAACTTTCATACCAAATTATAGGAATAATTTTACTCTCTATCTATAGGAAATAAC TCACTACCTCCCAAAGGCCTCAGTCTTAGAACATTGTTTATCATACTACATGTAGGAATTTTGAGGCTAT CCAATTTTATTTTAGTTATCACTACCATACTACATGTGTTATAATTATATCACCAAAAAAATCACTTTGT GTTGCCTTGCATTTTGGCCCCTGAGGAGGTATTATTCCTTGCCAAGCTATTCTTTTAATATCATTTACAA TTTATTCCGTATCCTTACCCTAGGGCTCCCAAGCCTAAATAAAACAGATAGCTTAGTAGTTATGCAAAGA ATCAGTCAGTTCATGCATACCTATCAGATAATTTAGTGGTTGATAGCTATATTTAGACTGAATGATGAAT GGAATGAAGCATATATAGCAGCTTACATAGCCCCAGGCTTGAAAGGAACCATTACAGATAAAATTGGTGG CATTCCACACTACCTCTGGGCAAAGGCAGGGGAGAAGCAACTAAAACTGCAACAGTTTCTGTAGCCATAC AAGGGAGTTTTGGGAGTAAGGAACACGTTGTTTGAGATAATCACAAGAAATTAAAACAGTCTCTAAATCC CATCCGTAACTGCAATGGATAGCATATTCCCAACTTGAGAGAGATCCTTTGTAATTTCAAGGACTGTAGG CATAAAATCCTAGATTATATTTTAAAACATTCAAAAAGATACTCTGCTCTTTTTGGCCCTAACTATATGC ATAAATTAAATACATGATTTATCAGGCCATAGGTCTGGTTGTCTTTACCCAACTTGTGATAATTGTATTT AAACTATTAAAATCCTTTTGTAAGAAGTTGTTTGAGATTTAAAGTATTGACAACTTATTTTCTCTTTTTC TATAGCTCACTATCACCTAAACCAGGCTATATACTTTTAGTAACCTCTAAACCATTTCTTCCCCTGTAGG TGTGAGAGTTCCATGAAGACAGAAAATGAAAAACTGAATGGAATCTTTAGCATCTATCCAGTACCTTGGA GCCCAAATCTCCCAGGAAAACTTTCACCCTTGGCTCCCATATGCTGGCTCAATTTCCAGATAGAGCTGTC AAAACCGCATCAGGTTCAAAGACAAAAGCTGCCTTGGTTACTTTCTAAATATGCCCAGGTACTTGCATAT TAAAAAAAAAAGTCTTCCATTTAACAAAATAGGTAATGTAAATTATAAGAATGTGAATTCCATAACTCAA GCTTAGGATTTAAGAAATTATTTTTTCTTTATTTTAGATTGGGGGTTTAATATTTTAACATTTAAAATTT TTAATCTGTATGAACATTTTTATTTTTTCCTAACTTTATCTCATGGGAAAAAAAGTGCTCGCCCCTGAAT TTTATTTTATGTGCTGCACAGTGATCTTCCCCGACTTGTACCTGTGTGTAGGTGTTCATGTGTATTAAGG GGCATGGGACAGACTCATTAGAGACAGGGATGAAATTTCCTTGGGTATATACAGAATAGCAGTTTAGAAT TACCCTGGTCTGAGTTCACTGTGACTCTATCCCTGGAGACAGGAATAGGTTCAGAAATGGGGCATGCCCA AGACCCTAGGGACCCTGGCAGCAGGGGGGCTGAAGAAGCTCTAGAGACCACGCAAAGAGTAAGTGTGGTA GGCTAGGTGCAGTGGCTCATGCCTGTCATCCCAGCACTTTGGGAGCCTGAGGCAAGAGGATCACTTGAGC CCAGGAGTTCAAGACCAGCCTGGGAGACAAAGTGAGATCTCATCTCTACAAAAAAAAATGTTAAATGATG CGAGAGGATCATTTGAGCCCAGGAGGTCAAGCTGCAATGAATCATGATCATGCCACTCCATTCCAGCCTG GGCAACAGAGCGAGACCCTTCAAAAAAAAAAAAAAGTATGGGCCTCATGCTCTCTCTTCACAGCTTCTGG TAACTCACCAAGAAATAGCTACAACGTGTCCTTGATTTTGTTTTTTGGCGAGGAATTGCTTGATCCTGAA AGTCTTGTAAGAAAACATGATGAGAAATGGTCAACCACACATACCACAATGGCAGAGAAAGGGAGAGAAC TTTGGAAACCTGTTTTAACCAAGCTTTTTTTTCCATATCTCTATCTGATGGACTTCTCCACACTTCTACA TCAGCAGCTTTATGACACTATACTGATCAAGTTTGGATGCCTTCTATTATTTTGAGGTATATTCTCACAG CTTGACATAAGGATCACCACTTAAGGATACTGTTTTGGGATCTGTGAGAGAAGAAATTCCTAAATCCTTG CACTTGTTAAAGCATCTGGCTTTCCCAGAGCATTCTGATATTTGTCAGAACTGGTTTAATCATAGTTTTT TTGTTGTTTGTTTTTGTTTTTGTTTTGGAGGGCTCTGCCTGGATTCTGTGACCTTTTGGAGTCCCTTGGA GGTCTGTGACAAAGAGGAAAGGAATTCCCAAGTCCAGCCTCACCCAAGCCCTGATTAGCTTAATTACTAG TTCTTTCACTAAGCCTCCAGTTGCATTTTTCAGTTAATATATCATTTGTAGAGAATCTTTAGATATTCCT ATTGATATTGTAGGCTAAAGGAAATTATTAACTCAATAACTTATGGCATTTCCATGAAATGCTTTGAAAT CCTGACTGTGATGAGAATTATGGTGGTAACTTTATAAAGAATATTCTCTTGTTTCCAAGCATCTGGATTG AGACCAGTGAATTATTTTGTAACAATTTTCTGAATGAACCCCAGGGTCAATTAAGTTTAGTTATCTGGGA CTCCAAAATCAGGGATATGGAGGCAAACATCCAATCTCACAACTCAGAGCATTTTTTTTGATTTCCCTTT TCAGTTTCACGGGCAGTAATCTAATCTTTAAGAGGCAACAAATAGCCCAATAGAGCCATGAGAACTCACC ATGTTTTGGACATTCTCTTCAGTAATATTGGTGTTATAATTCCAAGAAGCAAGTGAACTTTGATAGAACA GGTCTTCGGCTTCGTGGTTAAACTTGTCCAAAAATGTCTTGGCCTGTTCCTCAATGGTGGACTGAGCAGC AGTTACAGCAACAAGGCTGAGAAGGAGCCAGGAAGAGCTTGACATCGTCCCCTGTGAGCCAAGATCACAT CCACTGAATGACTTTCCCTAGACTAAAACCTCCTCATGAGATTTTCTCTCTTATCAGCCTTTGAACTTGG GTTGGGCGCTGAGCAGGAAAGACCAAAAAAAGAAAAAGAAGAAGAACACAGTAAACAATCTGCTGAGCCA ATATAAAGTTCATCCTGGAGAGGACAGATATGTAACAGATTTTAGAATAATTTTTTAAAGTGAATCAAAT AAGAATACGTTATTCTTTAATCCTAGAGAACCTTACCTCTCCTGTCACTTTATGGCCAAATCAAAACCGG TACTTTTGGTTAATATTTTCCTAGAAAGCTGTTAAAGATACACGGAAAATGTTATAATTTTACAGTGACC AAAGAGGTCTAGAACTAGGGATCATGAAGATAATGTTGGTGTTTGTATGGTTTTCAGACAATTTCATTAA TAGGTTATCTCACATTTATTTTTATTTCAAGATCATATTCCCAGAAACTCTCTACTTGGGCAACATTTTC CCTTCCAAATACATGACTTTGCCCTTGTCTTTATGGAATTCATATTTCTGATCAGTTTTTTTTTTTTTTT TTTTTTTGAGACTGAGTCTCGGTCTGTCGCCCAGGCTGGAGCACAGTGGCGCGATCTCGGCTCACTGCAA GCTCTGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCAC CACCACGCCCAGCTAAGTTTTTGTATTTTTAATAGAGACGGGGTTTCACCGTGTTAGTCAGGACGGTCTC TATCTCCTGACCTTGTGATCTGCCCAACTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACTGT GCCCAGCCATTTCTGATCAGTTTTAATTTCCATGGCCATTTTTTAAAATTATGACTACTCTCCACTCCAC AGGTCAACTCTCCTGATCTGCCTTTGCAAAACTTAAAAAAGCTCATTTCCTATTTCTCACACTGGTTCTG TGGCTGACTTCTTTGAGTGCCTCCTTCTCCTTCACTTACCTATTCAAAACTCAGTCAAGGTCACGTGGAA GTAAGAAAGCCTCCACATGGTATGAAATCCAAAGAGTATCTATGTCAACTCCTGATCCTCTGTAGCCATG GGATCACAACAACATAGAATTCAAAGAGATTTTAGTGGTTATCTTGTCAAATTTCAGAAGCGAGCTCAGT GTCCTCATTGCCAGAGTGTATGTATGAGTGCCACAGATCAAAGAGAGGAGCACTTTAAATGGCAGGGTTC AAGGGCCTACCTGACGATGATTGTGAAACTCTGACACAGAGAAAATATTTCTTCACCCAGAAAAACAAGT CTTCCAGGTTCAGGTGACATTGCAATAATCAAGCCTTTAAAAAAATGTCCACTGCTTTTCCTTATTCCAA AGTTGTGTATATTATTGTAGAATAGGAAAAAAACAATTATAAGTAACTATTCAAAGTGCTTTGTGTTATA ATATCTCATTTGAGCATCACAAGAAACCTATAGGCAAATATTTTATCACCATTTTATGAATTATGAAACT AAGTTTAAGTAAATTGCTATATCTCACTCAGCTAACAAATGATGGAATCAGAACATGGATCTATGTATTC TGATTCTAGAGTATAGGCTCTTAACTAACTTGTAGTCAACAGTCTAAAAGCAATAGTGGAGGCATAGATA AAATGTGACAGAGGGCCTTGTGCCTCAGTGAAGATGACAGATTTAGTTACACTGCATCAAAAAGAGGTGG ACTCTTACTTCCCTTGATGTGAATCAAAATATACTCTCCTTTTAAAAAAATAAAGCAGCTCACAAATATA AGTAATAATAATAAAGAATTTTAAATGAAAGTGAGATGAGGGTAAAAAAAAAAAATCAGTGCAGAAATTT CAGAAAAGCTCCTCCCACATTCCAGGAAACCTAGATCCACTCACTCCTTGCACACAATAGGAGAAAAAAC AGGCAAGAAAGAGGACAGCACACGAGTATCTGAAGAAAAGGTTGAAATGTTACTGTAATAAAAGCGGAAA TAAATTTCTACACAGGTAAGTTCCTAAATGAAACACGTGGGTTTAGTGGAAAAAATGGGAGTAGTCCAAA TTCAATTCGCTGAGGCAGAAAATACGATTAACTTGATCAAACTGAAATGGAGAAAGCAAGATATAAAATC TGAAAGCTAAGAATAAATGAACAAGGAGCCTGGGACAGCAGTGAGGCAGGCAGGAAAATGCTAGAAGCCA AGAAACTTTGAGAAGCAAGGGAAAAGGGAGAATAGTCTACAGTGATTCTGTAGAAAAACTAGCCCAGAAT GGCCAACTGCAAGCACTGACTGAATTATTGGAATTTTTGTTCACACTTTTTTGAGAAGATATCAATGTTC TGATAGTTCCCCAGAAGCGTTCTCTCTGAGCGCATTCCGAGAATGGAAAGAATTCACTGAAGACTCAGGA GATGAGACCCAGAAAAACAATTGGTCTAAAGGAATGTATTGTCTTTGAGAAAAATTGGAGAATCAGAAAA AATTAGAAGACCAAAGATGCAGGAAAGATGTTCTATGTTTCAAAAAGATTGGAGGAGGGGGTGGATTTCA TAATGGTAAAGGGAAGTTTGACCTTAACACCTAGTAAAGCTATAAAGTAAATTTTTTTTTTTTTGAGACG GAGTCTCGCTTTGTCACCCAGGCTGGAGTGCAGCGGCGCGATCTCCGCTCACTGCAAGCTCCGCCTCCCA GGTTCACGCCATTCTCCTGCCTCGGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCGCAGC TAATATTTTTGTATTTTTAATAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTTCTGACC TCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCGGCCTAAA GTAAAATTTTTAGAATGTGATTTGCACTTGGAAAAATATATCTCTGGTCCATTAGGAATTCACTAGGAAT AAGTCAGATGCTGCCTGCCCTATCTCCTCTCTGATAGAATACAATAGTAAAAAAATATATCCAAAGACGT AGTGTATCTTCCTTTTCAATAAGGGATTTAACAGAATGTAAAATGCTATGACTAGACCCAAATGTCCCCT GAAACAATTACACAGTACAGGATTAGGCAGTCCTCTGGTAAACAACAATTCATGTCCAAAACAACAAGAA TCTTGCTTCAATCATTGTTTATTGAATACCTACTATATGCCAAACACTATTCTAGATTTTGAATGTAAGC TAATAAATATTGTATTATATGAGGTGACAATAGAAGGAAGACAAAAATAGTGATAAATGTCATGACTTAT AATAAGCAAGAAATGGAGGATAGAGAATTATGGGGTGGGGAGAGGGATTTTCTATAAGGAGGGCCTCTCT GAGAAGGTGACGTTTGAGCAAAGACCGGAAAGAAGTGATGAAAGTTGTGCGGATCTCTGGGTGAAGAAGT TTTCCTAGGGAGAGGGAGCAGCAAGTGTAAAGGATGTAGGCAGATTTCAAGAACATCAGAGGTCTTTGTG ACTGGAGCTCAGTGTGCAGGGGAAAGTGGCAGGAGGTGAAGTCAAGGAAGAAGCTAGGGTCACACCAGGG AGGTCTTAAAGACAATTAACTGTGAGACTTCAGCTTTACTCTCAGCAACATGGGAAGACACTGGAAGGCT TCAAGCAGAGAAGTGATCTAGTAGAAGCTTTAGCAGGGTCACTTTGGCTGCTGCTTAGAGAATGGACACT AAAGGGGTAAGGATGGAAGCAGGGAGGCTAGTTAATGAGCTACTGCAGCAGCCCAGTCAAGCTGGTTGAA TAAAAGCTTAGTATGAGCTTCAAGATCCAACTAGGAGGCCCAGTAAAAATTACTGGGCCTATAATTACAT CTTATACTATATTAGACTTTGCTAATATAAGCATTAGATACAAAATAATCTAGACTATAACATTCATTTC TGTGAACCACAATTTTAGAGACGCACAAGAGAGCATCCAGAGGAAAATAAATAGGAGAGCAGATGGATCT AAAATAATATAATTTGGAGAATGGTTTAGATATGGAAGAGAAGACAGGGTGGACAGCTTTCTTCCATCAT GGTACTGCCATTTAGAAGAAGACTTAGCATAGTGGATTTACTCTGCCACTTGTTAGCTGTGTGACCTTAG GCAGGTAATATCCTCCCTGCACCTAATTTATTTCAAGGCCAATGATAGTTTTATATCCATTTCATAGGGA TGTCATATTACTTGAATTAATACATAAGAACACAGAGAGTAATGTTGTAAGCCTAGTAATAAAAGCCACA GAAAATGAAAGGAGCTGTGTAATAATTAGAGAACTTCCACACTGGAATGTTTAATCAAACCATCTGCAAG GTCATCTTTCAGAGACACTGCAGCAGACAGAGACTGGCTGGGAGTTTGACTCAAAGGTCTGTTTGGACTA TAGGATCCTGCATTGTAGGAGAAGTCTGCTAGTTTGTGCTGAAACAGCAGGATGGAGGAGCTCACCAATG GAATGAGTAGAGTCATATATGAAAGGAAAGGGGAGTCAGCCAGTAGTCTACATGAGCCCAGCCATAGAGA ACCTCTCAGCGTGCTTTCATCACCCAGTCATGGTCAGGTCCTGGTATAAAACTTCCTACATACAGAGAAG AGAAAACTTGAGTCTGTCACGCTATCTTGAGGAAGAAGGGGAAAGTCATAAAGGTAAATGACTCCCTCTC AATATTTACAGATGTTGTATTTGTTGGTTGCATATGCTTTGTACCTGCTCCTGTATATAAACTCTTCACA ACAACTTTACAGGTAGAAATAGTGAGATCCATTTTATAATTAAGGAAACCAACTGTTCCCATGATTAATT CAAACTTCCACAACTGATAGGCAATGGGGCTACATTTTGATCCCAGATTGCTTAAGAGACCTTTTCTCTC CACAGAGTCATGGGTTCAGTTATCTGCTAACTTCATGCATGTCTAATAAGTCCTCATCAATCTGTCATAT TCTGAGAATAAGCAGGTCCCCATAAGCAAAATTAAAATGTACTGCTTTGATTACACCAGTTATACATTTT TAAACCGTTTTAGTTAGAAATTTTTCTTCAATATATTCCATCCCGATCGCGATGCTGCCTGGACATTAGT TTAGGGTTATATTTCAGATGACTCAGTGTCATCATCTTAAATAATATTTACTGGCTAAGCTATAATGTGA CAATGTCTTCAAGGCTTTACATTAAATGACTCAACAGCTTTATTGCTATTAATTCTGCTGTTTCTGCACA TTCTGAGTTCACAGTCACAGTATCAACTTTCAGTAGCCCTGCTCTCCACAAGTCCCCTCCCTGTTTCTGA TCTGCTATCTGCTAAAACCTAAATGGAAACTAGATAACCATGGAGTTCAACTAGAAACCTCCCTTTTCAT AGGCTGAAATCCGAGGGTGGGTCTTTATTCTGCTAGAGCAAAGTACATAGACTTTGAAATCCATATTTCC CTTACTGTTCAACTTTTTATATCCTTCCAACTGAGTCACAAATGCTGAGGTTGCCAAATAGCTATAGGAG AAACCTCTTCCAGTTCCCCAAGTTGGGTGGATAACTTTGGTAAACATCAGAAAAGAAAGGATGTTTTGTT CAATTTCTTATTGATTAATACTGCTGACAGAACAAGGAAGGGTATCAGGAACACAATGCATAGAGAAATT CAAAACTTTGCATGGTCAAGAACTATTTGCATTCAGTACAATTGATTTTGACCACATGTTTATCACACAA AGTGAATTTATAAGTGCTTTATAGAAAATAAATAACTAGTTGGGCTTTCAGCCCAAAGGAAAAGCTAAAG CTCTTTCCTGTTTACATTTTTAGTTGCATAGCAGTCCCTTTTTTCCTAAATGTAAAAAGTAAAGTAGAGG TTCCTCTTCAAAGACTTTCCTCCCTGTCTAATTAGGAATAAATAATAGCTTCTCTTAGAAGCAAAATTCA TTCAAAAACCTGTGCTAACATTCTTAAATATCTGCTAGCCATAATAAAAAAAAATCAATGTACTTTATGT TCTTAGCTCCCACAATTTAACCTAAATATTTGCCCTGGCATCCTTAATACTGCTCCAAACAAGCATTAGG TCATAGCCTGTTCCTCTTCCTTATTTGAAGGGGTTTTTACCTTTCTCAACATTCCACAAGTTACTTCCTC CTTCCTTTGTTCTCCTCTGCCTTTGCCTCTTTTAAAAAGTTCTAA
Protein Name	ACE2_HUMAN
Length	805
Moltype	AA
Topology	linear
Division	PRI
Update Date	12-OCT-2022
Create Date	02-AUG-2005
Definition	RecName: Full=Angiotensin-converting enzyme 2; AltName: Full=Angiotensin-converting enzyme homolog; Short=ACEH; AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase; Short=ACE-related carboxypeptidase; AltName: Full=Metalloprotease MPROT15; Contains: RecName: Full=Processed angiotensin-converting enzyme 2; Flags: Precursor
Primary Accession	Q9BYF1
Accession Version	Q9BYF1.2
Other SeqIDs	sp\|Q9BYF1.2\|ACE2_HUMAN,gi\|71658783
Organism	Homo sapiens
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Comment	On or before Oct 11, 2005 this sequence version replaced gi:74738119, gi:74727705, gi:74752917, gi:74720759, gi:7512508.; [FUNCTION] Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). {ECO:0000269\|PubMed:10924499, ECO:0000269\|PubMed:10969042, ECO:0000269\|PubMed:11815627, ECO:0000269\|PubMed:14504186, ECO:0000269\|PubMed:18424768, ECO:0000269\|PubMed:19021774, ECO:0000269\|PubMed:19185582, ECO:0000269\|PubMed:27217402}.; [FUNCTION] (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. {ECO:0000269\|PubMed:14647384, ECO:0000269\|PubMed:15452268, ECO:0000269\|PubMed:15791205, ECO:0000269\|PubMed:15897467, ECO:0000269\|PubMed:19901337, ECO:0000269\|PubMed:24227843, ECO:0000269\|PubMed:32142651, ECO:0000269\|PubMed:32155444, ECO:0000269\|PubMed:32221306, ECO:0000269\|PubMed:32225175, ECO:0000269\|PubMed:33000221, ECO:0000269\|PubMed:33082294, ECO:0000269\|PubMed:33432067}.; [FUNCTION] [Isoform 2]: Non-functional as a carboxypeptidase. {ECO:0000269\|PubMed:33077916}.; [FUNCTION] [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. {ECO:0000269\|PubMed:33077916, ECO:0000269\|PubMed:33432184}.; [CATALYTIC ACTIVITY] Reaction=angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine; Xref=Rhea:RHEA:26554, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:58506, ChEBI:CHEBI:58922; EC=3.4.17.23; Evidence={ECO:0000269\|PubMed:10924499, ECO:0000269\|PubMed:11815627, ECO:0000269\|PubMed:19021774, ECO:0000305\|PubMed:14504186}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26555; Evidence={ECO:0000269\|PubMed:14504186}.; [CATALYTIC ACTIVITY] Reaction=angiotensin I + H2O = angiotensin-(1-9) + L-leucine; Xref=Rhea:RHEA:63532, ChEBI:CHEBI:15377, ChEBI:CHEBI:57427, ChEBI:CHEBI:147350, ChEBI:CHEBI:147351; Evidence={ECO:0000269\|PubMed:10924499, ECO:0000269\|PubMed:10969042, ECO:0000269\|PubMed:11815627, ECO:0000269\|PubMed:19021774}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63533; Evidence={ECO:0000305\|PubMed:10924499, ECO:0000305\|PubMed:10969042, ECO:0000305\|PubMed:11815627, ECO:0000305\|PubMed:19021774}.; [CATALYTIC ACTIVITY] Reaction=bradykinin(1-8) + H2O = bradykinin(1-7) + L-phenylalanine; Xref=Rhea:RHEA:63536, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:133069, ChEBI:CHEBI:147352; Evidence={ECO:0000269\|PubMed:10969042, ECO:0000269\|PubMed:11815627}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63537; Evidence={ECO:0000305\|PubMed:10969042, ECO:0000305\|PubMed:11815627}.; [CATALYTIC ACTIVITY] Reaction=H2O + neurotensin = L-leucine + neurotensin-(1-12); Xref=Rhea:RHEA:63540, ChEBI:CHEBI:15377, ChEBI:CHEBI:57427, ChEBI:CHEBI:147362, ChEBI:CHEBI:147363; Evidence={ECO:0000269\|PubMed:10969042}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63541; Evidence={ECO:0000305\|PubMed:10969042}.; [CATALYTIC ACTIVITY] Reaction=H2O + neurotensin-(1-8) = L-arginine + neurotensin-(1-7); Xref=Rhea:RHEA:63572, ChEBI:CHEBI:15377, ChEBI:CHEBI:32682, ChEBI:CHEBI:147393, ChEBI:CHEBI:147394; Evidence={ECO:0000269\|PubMed:11815627}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63573; Evidence={ECO:0000305\|PubMed:11815627}.; [CATALYTIC ACTIVITY] Reaction=H2O + kinetensin = kinetensin-(1-8) + L-leucine; Xref=Rhea:RHEA:63544, ChEBI:CHEBI:15377, ChEBI:CHEBI:57427, ChEBI:CHEBI:147364, ChEBI:CHEBI:147365; Evidence={ECO:0000269\|PubMed:10969042}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63545; Evidence={ECO:0000305\|PubMed:10969042}.; [CATALYTIC ACTIVITY] Reaction=dynorphin A-(1-13) + H2O = dynorphin A-(1-12) + L-lysine; Xref=Rhea:RHEA:63556, ChEBI:CHEBI:15377, ChEBI:CHEBI:32551, ChEBI:CHEBI:147381, ChEBI:CHEBI:147383; Evidence={ECO:0000269\|PubMed:11815627}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63557; Evidence={ECO:0000305\|PubMed:11815627}.; [CATALYTIC ACTIVITY] Reaction=apelin-13 + H2O = apelin-12 + L-phenylalanine; Xref=Rhea:RHEA:63564, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:147395, ChEBI:CHEBI:147396; Evidence={ECO:0000269\|PubMed:11815627}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63565; Evidence={ECO:0000305\|PubMed:11815627}.; [CATALYTIC ACTIVITY] Reaction=[Pyr1]apelin-13 + H2O = [Pyr1]apelin-12 + L-phenylalanine; Xref=Rhea:RHEA:63604, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:147415, ChEBI:CHEBI:147416; Evidence={ECO:0000269\|PubMed:27217402, ECO:0000269\|PubMed:28293165}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63605; Evidence={ECO:0000269\|PubMed:27217402}.; [CATALYTIC ACTIVITY] Reaction=apelin-17 + H2O = apelin-16 + L-phenylalanine; Xref=Rhea:RHEA:63608, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:147421, ChEBI:CHEBI:147422; Evidence={ECO:0000269\|PubMed:27217402}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63609; Evidence={ECO:0000269\|PubMed:27217402}.; [CATALYTIC ACTIVITY] Reaction=beta-casomorphin-7 + H2O = beta-casomorphin-6 + L-isoleucine; Xref=Rhea:RHEA:63568, ChEBI:CHEBI:15377, ChEBI:CHEBI:58045, ChEBI:CHEBI:147390, ChEBI:CHEBI:147391; Evidence={ECO:0000269\|PubMed:11815627}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63569; Evidence={ECO:0000305\|PubMed:11815627}.; [CATALYTIC ACTIVITY] Reaction=H2O + neocasomorphin = L-isoleucine + neocasomorphin-(1-5); Xref=Rhea:RHEA:63600, ChEBI:CHEBI:15377, ChEBI:CHEBI:58045, ChEBI:CHEBI:147417, ChEBI:CHEBI:147418; Evidence={ECO:0000269\|PubMed:11815627}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63601; Evidence={ECO:0000305\|PubMed:11815627}.; [COFACTOR] Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269\|PubMed:11815627}; Note=Binds 1 zinc ion per subunit. {ECO:0000269\|PubMed:11815627}.; [COFACTOR] Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence={ECO:0000269\|PubMed:11815627}; Note=Binds 1 Cl(-) ion per subunit. {ECO:0000269\|PubMed:11815627}.; ACTIVITY REGULATION: Regulated by chloride and fluoride, but not bromide (PubMed:11815627). Chloride increases angiotensin I and decreases angiotensin II cleavage (PubMed:19021774). Inhibited by MLN-4760, cFP_Leu, and EDTA (PubMed:15231706, PubMed:10924499), but not by the ACE inhibitors lisinopril, captopril and enalaprilat (PubMed:10969042, PubMed:10924499). Highly potent and selective in vitro ACE2 inhibitors were identified (PubMed:12358520). {ECO:0000269\|PubMed:10924499, ECO:0000269\|PubMed:10969042, ECO:0000269\|PubMed:11815627, ECO:0000269\|PubMed:12358520, ECO:0000269\|PubMed:15231706, ECO:0000269\|PubMed:19021774}.; [BIOPHYSICOCHEMICAL PROPERTIES] Kinetic parameters: KM=6.9 uM for angiotensin I {ECO:0000269\|PubMed:11815627}; KM=2.0 uM for angiotensin II {ECO:0000269\|PubMed:11815627}; KM=6.8 uM for apelin-13 {ECO:0000269\|PubMed:11815627}; KM=290 uM for [des-Arg(9)]-bradykinin {ECO:0000269\|PubMed:11815627}; KM=130 uM for Lys-[des-Arg(9)]-bradykinin {ECO:0000269\|PubMed:11815627}; KM=31 uM for beta-casomorphin {ECO:0000269\|PubMed:11815627}; KM=5.5 uM for dynorphin A-(1-13) {ECO:0000269\|PubMed:11815627}; KM=300 uM for neurotensin-(1-8) {ECO:0000269\|PubMed:11815627}; KM=58.6 uM for angiotensin II {ECO:0000269\|PubMed:19021774}; KM=12 uM for [Pyr1]apelin-13 {ECO:0000269\|PubMed:27217402}; KM=19 uM for apelin-17 {ECO:0000269\|PubMed:27217402}; Vmax=28.7 nmol/min/mg enzyme with angiotensin II as substrate {ECO:0000269\|PubMed:19021774}; Note=kcat is 0.034 sec(-1) with angiotensin I as substrate. kcat is 3.5 sec(-1) with angiotensin II as substrate. kcat is 13 sec(-1) with apelin-13 as substrate. kcat is 62 sec(-1) with [des-Arg(9)]-bradykinin as substrate. kcat is 26 sec(-1) with Lys-[des-Arg(9)]-bradykinin as substrate. kcat is 6.8 sec(-1) with beta-casomorphin as substrate. kcat is 16 sec(-1) with dynorphin A-(1-13) as substrate. kcat is 57 sec(-1) with neurotensin-(1-8) as substrate (PubMed:11815627). kcat is 19.1 sec(-1) with [Pyr1]apelin-13 as substrate. kcat is 7.7 sec(-1) with apelin-17 as substrate (PubMed:27217402). {ECO:0000269\|PubMed:11815627, ECO:0000269\|PubMed:27217402}; pH dependence: Optimum pH is 6.5 in the presence of 1 M NaCl. Active from pH 6 to 9. {ECO:0000269\|PubMed:11815627}.; [SUBUNIT] Homodimer (PubMed:32132184). Interacts with the catalytically active form of TMPRSS2 (PubMed:21068237). Interacts with SLC6A19; this interaction is essential for expression and function of SLC6A19 in intestine (By similarity). Interacts with ITGA5:ITGB1 (PubMed:15276642, PubMed:33102950). Probably interacts (via endocytic sorting signal motif) with AP2M1; the interaction is inhibited by phosphorylation of Tyr-781 (PubMed:33436498). Interacts (via PDZ-binding motif) with SLC9A3R1 (via PDZ domains); the interaction may enhance ACE2 membrane residence (PubMed:34189428). {ECO:0000250\|UniProtKB:Q8R0I0, ECO:0000269\|PubMed:15276642, ECO:0000269\|PubMed:21068237, ECO:0000269\|PubMed:32132184, ECO:0000269\|PubMed:33102950, ECO:0000269\|PubMed:33436498, ECO:0000269\|PubMed:34189428}.; [SUBUNIT] (Microbial infection) Interacts with SARS coronavirus/SARS-CoV spike protein. {ECO:0000269\|PubMed:14647384, ECO:0000269\|PubMed:15452268, ECO:0000269\|PubMed:15791205, ECO:0000269\|PubMed:32225175}.; [SUBUNIT] (Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 spike protein. {ECO:0000269\|PubMed:32075877, ECO:0000269\|PubMed:32132184, ECO:0000269\|PubMed:32155444, ECO:0000269\|PubMed:32225175, ECO:0000269\|PubMed:32753553, ECO:0000269\|PubMed:33102950, ECO:0000269\|PubMed:33432067}.; [SUBUNIT] (Microbial infection) Interacts with human coronavirus NL63 spike protein. {ECO:0000269\|PubMed:19901337}.; [SUBUNIT] (Microbial infection) Interacts with human coronavirus NL63/HCoV-NL63 spike glycoprotein. {ECO:0000269\|PubMed:15897467}.; [SUBUNIT] [Processed angiotensin-converting enzyme 2]: (Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 spike protein; the interaction is increased by AVP/Arg-vasopressin with which they may form a complex. {ECO:0000269\|PubMed:33713620}.; [INTERACTION] Q9BYF1; Q9BYF1: ACE2; NbExp=8; IntAct=EBI-7730807, EBI-7730807; Q9BYF1; PRO_0000032457 [P01019]: AGT; NbExp=2; IntAct=EBI-7730807, EBI-25493366; Q9BYF1; PRO_0000032458 [P01019]: AGT; NbExp=5; IntAct=EBI-7730807, EBI-6622938; Q9BYF1; Q96CW1: AP2M1; NbExp=2; IntAct=EBI-7730807, EBI-297683; Q9BYF1; PRO_0000000092 [P05067]: APP; NbExp=3; IntAct=EBI-7730807, EBI-821758; Q9BYF1; Q9H2X3: CLEC4M; NbExp=3; IntAct=EBI-7730807, EBI-1391211; Q9BYF1; PRO_0000417390 [Q01523]: DEFA5; NbExp=4; IntAct=EBI-7730807, EBI-25634589; Q9BYF1; Q14416: GRM2; NbExp=2; IntAct=EBI-7730807, EBI-10232876; Q9BYF1; P11021: HSPA5; NbExp=6; IntAct=EBI-7730807, EBI-354921; Q9BYF1; P05556: ITGB1; NbExp=4; IntAct=EBI-7730807, EBI-703066; Q9BYF1; O60341: KDM1A; NbExp=19; IntAct=EBI-7730807, EBI-710124; Q9BYF1; PRO_0000006688 [P01042]: KNG1; NbExp=5; IntAct=EBI-7730807, EBI-6623273; Q9BYF1; PRO_0000019524 [P30990]: NTS; NbExp=2; IntAct=EBI-7730807, EBI-6655817; Q9BYF1; Q5T2W1: PDZK1; NbExp=3; IntAct=EBI-7730807, EBI-349819; Q9BYF1; P35247: SFTPD; NbExp=2; IntAct=EBI-7730807, EBI-11316157; Q9BYF1; Q9Y566: SHANK1; NbExp=2; IntAct=EBI-7730807, EBI-3442234; Q9BYF1; Q695T7: SLC6A19; NbExp=4; IntAct=EBI-7730807, EBI-25475705; Q9BYF1; O14745: SLC9A3R1; NbExp=7; IntAct=EBI-7730807, EBI-349787; Q9BYF1; Q96L92: SNX27; NbExp=2; IntAct=EBI-7730807, EBI-2514865; Q9BYF1; O15393: TMPRSS2; NbExp=3; IntAct=EBI-7730807, EBI-12549863; Q9BYF1; P08670: VIM; NbExp=4; IntAct=EBI-7730807, EBI-353844; Q9BYF1; P52293: Kpna2; Xeno; NbExp=4; IntAct=EBI-7730807, EBI-3043908; Q9BYF1; A0A6B9WHD3: S; Xeno; NbExp=2; IntAct=EBI-7730807, EBI-25496413; Q9BYF1; A0A6G6A1M4: S; Xeno; NbExp=4; IntAct=EBI-7730807, EBI-26997256; Q9BYF1; A0A6M3G9R1: S; Xeno; NbExp=4; IntAct=EBI-7730807, EBI-26997195; Q9BYF1; P0DTC2: S; Xeno; NbExp=254; IntAct=EBI-7730807, EBI-25474821; Q9BYF1; PRO_0000449647 [P0DTC2]: S; Xeno; NbExp=2; IntAct=EBI-7730807, EBI-25490323; Q9BYF1; P59594: S; Xeno; NbExp=57; IntAct=EBI-7730807, EBI-15582614; Q9BYF1; PRO_0000037209 [P59594]: S; Xeno; NbExp=3; IntAct=EBI-7730807, EBI-25475261; Q9BYF1; Q5GDB5: S; Xeno; NbExp=2; IntAct=EBI-7730807, EBI-25566398; Q9BYF1; Q6Q1S2: S; Xeno; NbExp=9; IntAct=EBI-7730807, EBI-15814420.; [SUBCELLULAR LOCATION] [Processed angiotensin-converting enzyme 2]: Secreted {ECO:0000269\|PubMed:15983030, ECO:0000269\|PubMed:33713620}.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269\|PubMed:18424768}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250\|UniProtKB:Q8R0I0}. Cell projection, cilium {ECO:0000269\|PubMed:33432184}. Apical cell membrane {ECO:0000269\|PubMed:33432184}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250\|UniProtKB:Q8R0I0}.; [SUBCELLULAR LOCATION] [Isoform 2]: Apical cell membrane {ECO:0000269\|PubMed:33432184}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=long {ECO:0000303\|PubMed:33432184}; IsoId=Q9BYF1-1; Sequence=Displayed; Name=2; Synonyms=delta {ECO:0000303\|PubMed:33077916}, dACE2 {ECO:0000303\|PubMed:33077916}, short {ECO:0000303\|PubMed:33432184}; IsoId=Q9BYF1-3; Sequence=VSP_060903.; [TISSUE SPECIFICITY] Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells (at protein level) (PubMed:15141377). Expressed in enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level) (PubMed:15141377). Expressed in the renal proximal tubule and the small intestine (at protein level) (PubMed:18424768). Expressed in heart, kidney, testis, and gastrointestinal system (at protein level) (PubMed:10969042, PubMed:10924499, PubMed:15231706, PubMed:12459472, PubMed:15671045, PubMed:32715618, PubMed:32170560). In lung, expressed at low levels in some alveolar type 2 cells, the expression seems to be individual-specific (at protein level) (PubMed:32425701, PubMed:15141377, PubMed:32715618, PubMed:32170560, PubMed:33432184). Expressed in nasal epithelial cells (at protein level) (PubMed:33432184, PubMed:32333915). Coexpressed with TMPRSS2 within some lung alveolar type 2 cells, ileal absorptive enterocytes, intestinal epithelial cells, cornea, gallbladder and nasal goblet secretory cells (PubMed:32413319, PubMed:32327758, PubMed:32358202). Coexpressed with TMPRSS4 within mature enterocytes (PubMed:32404436). {ECO:0000269\|PubMed:10924499, ECO:0000269\|PubMed:10969042, ECO:0000269\|PubMed:12459472, ECO:0000269\|PubMed:15141377, ECO:0000269\|PubMed:15231706, ECO:0000269\|PubMed:15671045, ECO:0000269\|PubMed:18424768, ECO:0000269\|PubMed:32170560, ECO:0000269\|PubMed:32327758, ECO:0000269\|PubMed:32333915, ECO:0000269\|PubMed:32358202, ECO:0000269\|PubMed:32404436, ECO:0000269\|PubMed:32413319, ECO:0000269\|PubMed:32425701, ECO:0000269\|PubMed:32715618, ECO:0000269\|PubMed:33432184}.; [TISSUE SPECIFICITY] [Isoform 2]: Expressed in nasal and bronchial epithelial cells (at protein level). {ECO:0000269\|PubMed:33432184}.; [INDUCTION] Up-regulated in failing heart (PubMed:14504186, PubMed:15151696, PubMed:15671045). Expression is induced by IFNA and IFNG (PubMed:32413319, PubMed:32425701). Exposure to cigarette smoke increases expression in lungs (PubMed:32425701). Expression is decreased in nasal and bronchial epithelium of individuals with allergy after allergen challenge (PubMed:32333915). IL13 stimulation decreases expression in nasal and bronchial epithelium (PubMed:32333915). {ECO:0000269\|PubMed:14504186, ECO:0000269\|PubMed:15151696, ECO:0000269\|PubMed:15671045, ECO:0000269\|PubMed:32333915, ECO:0000269\|PubMed:32413319, ECO:0000269\|PubMed:32425701}.; [INDUCTION] [Isoform 1]: Not induced by interferons such as IFNA, IFNB and IFNG. {ECO:0000269\|PubMed:33077916}.; [INDUCTION] [Isoform 2]: Expression is induced by interferons such as IFNA, IFNB and IFNG. It seems that isoform 2 is an interferon-stimulated gene (ISG) but not isoform 1. {ECO:0000269\|PubMed:33077916}.; [INDUCTION] (Microbial infection) In airway epithelial cells, expression is increased upon influenza A virus infection (PubMed:32413319). {ECO:0000269\|PubMed:32413319}.; [INDUCTION] [Isoform 2]: (Microbial infection) In airway epithelial cells, expression is induced by viruses such rhinoviruses and influenza virus. {ECO:0000269\|PubMed:33077916, ECO:0000269\|PubMed:33432184}.; [INDUCTION] [Isoform 2]: (Microbial infection) Induced by human coronavirus SARS-CoV-2. {ECO:0000269\|PubMed:33077916}.; [DOMAIN] The extracellular region of the ACE2 enzyme is composed of two domains. The first is a zinc metallopeptidase domain (residues 19-611). The second domain is located at the C-terminus (residues 612-740) and is 48% identical to human collectrin. {ECO:0000269\|PubMed:14754895}.; [DOMAIN] The cytoplasmic tail contains several linear motifs such as LIR, PDZ-binding, PTB and endocytic sorting signal motifs that would allow interaction with proteins that mediate endocytic trafficking and autophagy. {ECO:0000305\|PubMed:33436497, ECO:0000305\|PubMed:33436498}.; [PTM] N-glycosylation on Asn-90 may limit SARS infectivity. {ECO:0000269\|PubMed:10924499, ECO:0000269\|PubMed:14647384, ECO:0000269\|PubMed:14754895, ECO:0000269\|PubMed:15084671, ECO:0000269\|PubMed:19159218}.; [PTM] Proteolytic cleavage by ADAM17 generates a secreted form (PubMed:15983030, PubMed:33713620). Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. {ECO:0000269\|PubMed:15983030, ECO:0000269\|PubMed:21068237, ECO:0000269\|PubMed:21563828, ECO:0000269\|PubMed:24227843, ECO:0000269\|PubMed:32132184, ECO:0000269\|PubMed:33713620}.; [PTM] Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains. {ECO:0000305\|PubMed:33436497, ECO:0000305\|PubMed:33436498}.; [BIOTECHNOLOGY] An engeneered stable, dimeric and secreted receptor with combined mutations that increase the affinity for human coronavirus SARS-CoV-2 spike protein shows potent SARS-CoV and SARS-CoV-2 neutralization in vitro. {ECO:0000269\|PubMed:32753553}.; [SIMILARITY] Belongs to the peptidase M2 family. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=AAQ89076.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/ace2/'.; [WEB RESOURCE] Name=Protein Spotlight; Note=A way in - Issue 223 of March 2020; URL='https://web.expasy.org/spotlight/back_issues/223/'.
Source Db	UniProtKB: locus ACE2_HUMAN, accession Q9BYF1;; class: standard.; extra accessions:A0A7D6JAD5,C7ECU1,Q6UWP0,Q86WT0,Q9NRA7,Q9UFZ6; created: Aug 2, 2005.; sequence updated: Aug 2, 2005.; annotation updated: Oct 12, 2022.; xrefs: AF291820.1, AAF99721.1, AF241254.1, AAF78220.1, AY623811.1, AAT45083.1, AB193259.1, BAD99266.1, AB193260.1, BAD99267.1, AB046569.1, BAB40370.1, E39033.1, GQ262784.1, ACT66268.1, MT505392.1, QLP88822.1, AY358714.1, AAQ89076.1, AY217547.1, AAO25651.1, CH471074.1, EAW98892.1, BC039902.1, AAH39902.1, BC048094.1, AAH48094.2, AL110224.1, CAB53682.1, T14762, NP_068576.1, 1R42_A, 1R4L_A, 2AJF_A, 2AJF_B, 3D0G_A, 3D0G_B, 3D0H_A, 3D0H_B, 3D0I_A, 3D0I_B, 3KBH_A, 3KBH_B, 3KBH_C, 3KBH_D, 3SCI_A, 3SCI_B, 3SCJ_A, 3SCJ_B, 3SCK_A, 3SCK_B, 3SCL_A, 3SCL_B, 6ACG_D, 6ACJ_D, 6ACK_D, 6CS2_D, 6LZG_A, 6M0J_A, 6M17_B, 6M17_D, 6M18_B, 6M18_D, 6M1D_B, 6M1D_D, 6VW1_A, 6VW1_B, 7A91_D, 7A92_D, 7A94_D, 7A95_D, 7A96_D, 7A97_D, 7A97_E, 7A98_D, 7A98_E, 7A98_F, 7BH9_A, 7CT5_D, 7CT5_E, 7CT5_F, 7DDO_A, 7DDP_A, 7DF4_A, 7DMU_A, 7DMU_C, 7DQA_A, 7DRV_A, 7DRV_B, 7DWX_B, 7DWX_D, 7DX4_A, 7DX5_D, 7DX6_D, 7DX7_D, 7DX8_D, 7DX8_E, 7DX9_D, 7DX9_E, 7E7E_A, 7E7E_B, 7EDJ_I, 7EDJ_J, 7EDJ_K, 7EFP_A, 7EFR_A, 7EKC_A, 7EKE_A, 7EKF_A, 7EKG_A, 7EKH_A, 7FDG_A, 7FDH_A, 7FDI_A, 7FEM_D, 7JVO_B, 7KJ2_D, 7KJ3_D, 7KJ3_E, 7KJ4_D, 7KJ4_E, 7KJ4_F, 7KMB_F, 7KMS_D, 7KMS_E, 7KMS_F, 7KMZ_D, 7KMZ_E, 7KNB_D, 7KNE_D, 7KNH_D, 7KNH_E, 7KNI_D, 7KNI_E, 7KNI_F, 7L0N_E, 7L0N_F, 7L7F_B, 7L7F_D, 7LO4_A, 7MJM_D, 7MJM_E, 7MJN_E, 7NXC_A, 7PKI_A, 7R0Z_D, 7R10_D, 7R11_D, 7R12_D, 7R1A_D, 7R1A_E, 7R1A_F, 7RPV_A, 7RPV_B, 7RPV_C, 7RPV_D, 7SN0_A, 7SN0_B, 7SXX_E, 7SXY_E, 7SXZ_E, 7SY0_E, 7SY1_E, 7SY2_E, 7SY3_E, 7SY4_E, 7SY5_D, 7SY5_E, 7SY5_F, 7SY6_E, 7SY7_E, 7SY8_E, 7T9K_D, 7T9K_E, 7T9L_D, 7TEW_E, 7TEX_E, 7TEZ_E, 7TF0_E, 7TN0_E, 7TN0_F, 7U0N_A, 7U0N_B, 7V7Z_D, 7V7Z_E, 7V7Z_F, 7V80_F, 7V81_D, 7V81_E, 7V82_D, 7V82_E, 7V82_F, 7V83_D, 7V83_E, 7V83_F, 7V84_F, 7V85_F, 7V85_H, 7V86_F, 7V86_G, 7V86_H, 7V87_F, 7V88_F, 7V88_G, 7V89_F, 7V89_G, 7V89_H, 7V8A_F, 7V8A_G, 7V8A_H, 7V8B_F, 7VX4_A, 7VX5_A, 7VX9_C, 7VXA_C, 7VXB_C, 7VXC_C, 7VXD_C, 7VXF_C, 7VXK_C, 7VXM_C, 7W98_D, 7W99_B, 7W9B_A, 7W9C_A, 7W9I_A, 7WBL_A, 7WBP_A, 7WBQ_A, 7WBQ_C, 7WK4_A, 7WK5_A, 7WK6_A, 7WPA_D, 7WPB_D, 7WPC_D, 7WVP_A, 7WVQ_A; xrefs (non-sequence databases): CCDS:CCDS14169.1, PDBsum:1R42, PDBsum:1R4L, PDBsum:2AJF, PDBsum:3D0G, PDBsum:3D0H, PDBsum:3D0I, PDBsum:3KBH, PDBsum:3SCI, PDBsum:3SCJ, PDBsum:3SCK, PDBsum:3SCL, PDBsum:6ACG, PDBsum:6ACJ, PDBsum:6ACK, PDBsum:6CS2, PDBsum:6LZG, PDBsum:6M0J, PDBsum:6M17, PDBsum:6M18, PDBsum:6M1D, PDBsum:6VW1, PDBsum:7A91, PDBsum:7A92, PDBsum:7A94, PDBsum:7A95, PDBsum:7A96, PDBsum:7A97, PDBsum:7A98, PDBsum:7BH9, PDBsum:7CT5, PDBsum:7DDO, PDBsum:7DDP, PDBsum:7DF4, PDBsum:7DMU, PDBsum:7DQA, PDBsum:7DRV, PDBsum:7DWX, PDBsum:7DX4, PDBsum:7DX5, PDBsum:7DX6, PDBsum:7DX7, PDBsum:7DX8, PDBsum:7DX9, PDBsum:7E7E, PDBsum:7EDJ, PDBsum:7EFP, PDBsum:7EFR, PDBsum:7EKC, PDBsum:7EKE, PDBsum:7EKF, PDBsum:7EKG, PDBsum:7EKH, PDBsum:7FDG, PDBsum:7FDH, PDBsum:7FDI, PDBsum:7FEM, PDBsum:7JVO, PDBsum:7KJ2, PDBsum:7KJ3, PDBsum:7KJ4, PDBsum:7KMB, PDBsum:7KMS, PDBsum:7KMZ, PDBsum:7KNB, PDBsum:7KNE, PDBsum:7KNH, PDBsum:7KNI, PDBsum:7L0N, PDBsum:7L7F, PDBsum:7LO4, PDBsum:7MJM, PDBsum:7MJN, PDBsum:7NXC, PDBsum:7PKI, PDBsum:7R0Z, PDBsum:7R10, PDBsum:7R11, PDBsum:7R12, PDBsum:7R1A, PDBsum:7RPV, PDBsum:7SN0, PDBsum:7SXX, PDBsum:7SXY, PDBsum:7SXZ, PDBsum:7SY0, PDBsum:7SY1, PDBsum:7SY2, PDBsum:7SY3, PDBsum:7SY4, PDBsum:7SY5, PDBsum:7SY6, PDBsum:7SY7, PDBsum:7SY8, PDBsum:7T9K, PDBsum:7T9L, PDBsum:7TEW, PDBsum:7TEX, PDBsum:7TEZ, PDBsum:7TF0, PDBsum:7TN0, PDBsum:7U0N, PDBsum:7V7Z, PDBsum:7V80, PDBsum:7V81, PDBsum:7V82, PDBsum:7V83, PDBsum:7V84, PDBsum:7V85, PDBsum:7V86, PDBsum:7V87, PDBsum:7V88, PDBsum:7V89, PDBsum:7V8A, PDBsum:7V8B, PDBsum:7VX4, PDBsum:7VX5, PDBsum:7VX9, PDBsum:7VXA, PDBsum:7VXB, PDBsum:7VXC, PDBsum:7VXD, PDBsum:7VXF, PDBsum:7VXK, PDBsum:7VXM, PDBsum:7W98, PDBsum:7W99, PDBsum:7W9B, PDBsum:7W9C, PDBsum:7W9I, PDBsum:7WBL, PDBsum:7WBP, PDBsum:7WBQ, PDBsum:7WK4, PDBsum:7WK5, PDBsum:7WK6, PDBsum:7WPA, PDBsum:7WPB, PDBsum:7WPC, PDBsum:7WVP, PDBsum:7WVQ, AlphaFoldDB:Q9BYF1, SMR:Q9BYF1, BioGRID:121864, ComplexPortal:CPX-5683, ComplexPortal:CPX-5684, ComplexPortal:CPX-5695, DIP:DIP-44689N, IntAct:Q9BYF1, MINT:Q9BYF1, STRING:9606.ENSP00000389326, BindingDB:Q9BYF1, ChEMBL:CHEMBL3736, DrugBank:DB09019, DrugBank:DB00608, DrugBank:DB01611, DrugBank:DB15643, DrugBank:DB05203, GuidetoPHARMACOLOGY:1614, MEROPS:M02.006, TCDB:2.A.22.6.3, TCDB:8.A.139.1.1, GlyConnect:1012, GlyGen:Q9BYF1, iPTMnet:Q9BYF1, PhosphoSitePlus:Q9BYF1, BioMuta:ACE2, DMDM:71658783, jPOST:Q9BYF1, MassIVE:Q9BYF1, PaxDb:Q9BYF1, PeptideAtlas:Q9BYF1, PRIDE:Q9BYF1, ProteomicsDB:79634, ABCD:Q9BYF1, Antibodypedia:344, DNASU:59272, Ensembl:ENST00000252519.8, Ensembl:ENSP00000252519.3, Ensembl:ENSG00000130234.13, Ensembl:ENST00000427411.2, Ensembl:ENSP00000389326.1, Ensembl:ENST00000677282.1, Ensembl:ENSP00000504747.1, Ensembl:ENST00000678073.1, Ensembl:ENSP00000504103.1, Ensembl:ENST00000680121.1, Ensembl:ENSP00000505992.1, GeneID:59272, KEGG:hsa:59272, MANE-Select:ENST00000252519.8, UCSC:uc004cxa.2, CTD:59272, DisGeNET:59272, GeneCards:ACE2, HGNC:13557, HPA:ENSG00000130234, MIM:300335, neXtProt:NX_Q9BYF1, OpenTargets:ENSG00000130234, PharmGKB:PA425, VEuPathDB:HostDB:ENSG00000130234, eggNOG:KOG3690, GeneTree:ENSGT00940000158077, HOGENOM:CLU_014364_3_0_1, InParanoid:Q9BYF1, OMA:EMARANX, OrthoDB:422699at2759, PhylomeDB:Q9BYF1, TreeFam:TF312861, BRENDA:3.4.15.1, BRENDA:3.4.17.23, PathwayCommons:Q9BYF1, Reactome:R-HSA-2022377, Reactome:R-HSA-9678110, Reactome:R-HSA-9679191, Reactome:R-HSA-9694614, SABIO-RK:Q9BYF1, SignaLink:Q9BYF1, SIGNOR:Q9BYF1, BioGRID-ORCS:59272, ChiTaRS:ACE2, EvolutionaryTrace:Q9BYF1, GeneWiki:Angiotensin-converting_enzyme_2, GenomeRNAi:59272, Pharos:Q9BYF1, PRO:PR:Q9BYF1, Proteomes:UP000005640, RNAct:Q9BYF1, Bgee:ENSG00000130234, ExpressionAtlas:Q9BYF1, Genevisible:Q9BYF1, GO:0016324, GO:0031526, GO:0009986, GO:0005929, GO:0030666, GO:0005788, GO:0070062, GO:0005576, GO:0005615, GO:0016021, GO:0016020, GO:0045121, GO:0005886, GO:0004180, GO:0004175, GO:0042802, GO:0004181, GO:0008237, GO:0008241, GO:0001618, GO:0008270, GO:0002003, GO:0003051, GO:0097746, GO:0060135, GO:0061025, GO:0070373, GO:2000272, GO:0048662, GO:0051957, GO:0060452, GO:1903598, GO:1905737, GO:2000379, GO:0019065, GO:0046813, GO:1903779, GO:0042127, GO:0001817, GO:0050727, GO:0003081, GO:0022898, GO:0019229, GO:0015827, GO:0046718, GO:0019058, CDD:cd06461, DisProt:DP02854, InterPro:IPR031588, InterPro:IPR001548, PANTHER:PTHR10514, Pfam:PF16959, Pfam:PF01401, PRINTS:PR00791, PROSITE:PS00142
Sequence	msssswlllslvavtaaqstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadqsikvrislksalgdkayewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtevekairmsrsrindafrlndnsleflgiqptlgppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkknkarsgenpyasidiskgennpgfqntddvqtsf