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| Record Information |
| Record ID |
237 |
| Pubmed ID |
34484238 |
| SNP |
|
| Gene ID |
5196 |
| Protein ID |
P02776 |
| Vaccine Adverse Events |
vaccineinduced immune thrombotic thrombocytopenia |
| Vaccine |
COVID-19 Vaccine |
| Gene Name |
PF4 |
| Official Symbol |
platelet factor 4 [Homo sapiens (human)] |
| Aliases |
CXCL4, PF-4, SCYB4 |
| Other Designations |
platelet factor 4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; iroplact; oncostatin-A |
| Chromosome |
4 |
| Location |
4q13.3 |
| Annotation |
Chromosome 4 NC_000004.12 (73980811..73982124, complement) |
| MIM |
173460 |
| DNA Sequence |
>NC_000004.12:73980811-73982124 Homo sapiens chromosome 4, GRCh38.p14 Primary Assembly
TTTTTTAAAAGCCATCTGTGTTACTGATATTTATTGGCAAAGGTAATAATAATGGTCAAGGTAAATATGT
AGCTATAAAGTACTGCAATCATGTAAATGCATGAATATGTATCAGCCAACATGTAACACCAAGCATAACC
AGTATTCACACCTTCCTTCAAAATACTTTTTGCTTAAAATACCGGAATTTTTTTCTTCCATGAAATTGTT
ATGTGTCAACACAATTTTTGCACTATTATTAAGAAGTATTTTGACTATACTACAACTTGATTTATTTTGT
TTATTTAAAATCATAAGGATAACACAAATATCAGAAGTTCTTTCACAGTTAGATTGAAACTGGAAAAAAG
AAGTATGCTATATAGCAAATGCACACACGTAGGCAGCTAGTAGCTAACTCTCCAAAAGTTTCTTAATTAT
TTTCTTGTACAGCGGGGCTTGCAGGTCCAAGCAAATTTTCCTTCCATTCTTCAGCGTGGCTCTGGCAGGG
AAAAGAGAAGAGATGTGACTTTCAGTCCTTGGGTTTGCAAATGGCATTAGAAGGGGGAGGGTTGGGCAGA
GGAGGCACGGAGCGGGAGCACTGACAGATGCAGTGCAAGGACTCACATCAGTTGGGCAGTGGGGCAGTGG
GGTCCGGCCTTGATCACCTCCAGGCTGGTGATGTGCCTGGGACGGACCTGGGAGGTGGTCTTCACACACA
GGCACTGCAGGTCCCCATCTTCTTCAGCTTCAGCTGAGGGGGAAATGGAGAGGGTAAGAGAGGAGGAGGG
GAGGGAGTGGTGACTCCATGAGTAGCCAGAGGTACTTTAGGGACTTTTTCCACTACCTTCAGCCTTCTTT
TCCTTACCATAAATCACACCTCCCCCAGACAGAAGTTGTTCTAACCAGGTGGGAGGTGCAGGTGCAGCGC
CTGGCACTGTGGCCAGACACTCAGCAGGCTCTCCGTTAAGTGTGGCTGTGATCATGATCCTAGAGGATTC
CTCCCCAGCCCCAGGGCTTCCCGGACTCCCCCTCGCCGCTGCCAGCCCTCACAGCCTGGCTTCTGCTCTC
ACCGCTGGCGAAGGCGACCACAAGTGGCAGGAGCAGCAACCCCAGGAACAGCAGCCCGGGGCGTGAGGCG
CAGAACCCGGCTGCGGAGCTCATGCTGCGGCAGAGCTTCCAGCAGGATCTCAGTGCTCAGTGCGATGGGA
AACTCGGGCTGGGTCTCTGTGGCCAATGACTCCTGAGCCTCGCCGGCACGTTTTATTCCCGGCTGTCCTT
CCAGTCCGGAAGCCTGAAGTGGACACCGAGGAACTGCGGTGCGGAAACTAAGAT
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| Protein Name |
PLF4_HUMAN |
| Length |
101 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
21-JUL-1986 |
| Definition |
RecName: Full=Platelet factor 4; Short=PF-4; AltName: Full=C-X-C motif chemokine 4; AltName: Full=Iroplact; AltName: Full=Oncostatin-A; Contains: RecName: Full=Platelet factor 4, short form; AltName: Full=Endothelial cell growth inhibitor; Flags: Precursor |
| Primary Accession |
P02776 |
| Accession Version |
P02776.2 |
| Other SeqIDs |
sp|P02776.2|PLF4_HUMAN,gi|130304 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Sep 26, 2008 this sequence version replaced gi:74725529, gi:74720129, gi:74740791, gi:2144899.; [FUNCTION] Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. {ECO:0000269|PubMed:7644496}.; [SUBUNIT] Homotetramer (PubMed:7547867, PubMed:8031770). Interacts with TNFAIP6 (via Link domain) (PubMed:27044744). {ECO:0000269|PubMed:27044744, ECO:0000269|PubMed:7547867, ECO:0000269|PubMed:8031770}.; [INTERACTION] P02776; P02749: APOH; NbExp=2; IntAct=EBI-2565740, EBI-2114682; P02776; P51671: CCL11; NbExp=2; IntAct=EBI-2565740, EBI-727357; P02776; Q99616: CCL13; NbExp=2; IntAct=EBI-2565740, EBI-725342; P02776; Q92583: CCL17; NbExp=2; IntAct=EBI-2565740, EBI-16640146; P02776; P13500: CCL2; NbExp=2; IntAct=EBI-2565740, EBI-1034732; P02776; P78556: CCL20; NbExp=2; IntAct=EBI-2565740, EBI-3913209; P02776; O00585: CCL21; NbExp=2; IntAct=EBI-2565740, EBI-953695; P02776; O15444: CCL25; NbExp=3; IntAct=EBI-2565740, EBI-7783341; P02776; Q9Y258: CCL26; NbExp=3; IntAct=EBI-2565740, EBI-7783416; P02776; Q9NRJ3: CCL28; NbExp=3; IntAct=EBI-2565740, EBI-7783254; P02776; P13501: CCL5; NbExp=6; IntAct=EBI-2565740, EBI-2848366; P02776; PRO_0000005175 [P13501]: CCL5; NbExp=3; IntAct=EBI-2565740, EBI-11712923; P02776; P02778: CXCL10; NbExp=2; IntAct=EBI-2565740, EBI-7815386; P02776; O14625: CXCL11; NbExp=2; IntAct=EBI-2565740, EBI-2871971; P02776; P48061: CXCL12; NbExp=4; IntAct=EBI-2565740, EBI-3913254; P02776; O95715: CXCL14; NbExp=3; IntAct=EBI-2565740, EBI-2798068; P02776; Q6UXB2: CXCL17; NbExp=2; IntAct=EBI-2565740, EBI-16804198; P02776; P19875: CXCL2; NbExp=3; IntAct=EBI-2565740, EBI-2114901; P02776; P80162: CXCL6; NbExp=2; IntAct=EBI-2565740, EBI-9214033; P02776; P10145: CXCL8; NbExp=2; IntAct=EBI-2565740, EBI-3917999; P02776; Q07325: CXCL9; NbExp=3; IntAct=EBI-2565740, EBI-3911467; P02776; P47992: XCL1; NbExp=2; IntAct=EBI-2565740, EBI-10209901; PRO_0000005068; PRO_0000002059 [P02749]: APOH; NbExp=4; IntAct=EBI-11809981, EBI-11809989; PRO_0000005068; P0DTC2: S; Xeno; NbExp=3; IntAct=EBI-11809981, EBI-25474821; PRO_0000351217; P13501: CCL5; NbExp=2; IntAct=EBI-20561364, EBI-2848366; PRO_0000351217; PRO_0000005175 [P13501]: CCL5; NbExp=2; IntAct=EBI-20561364, EBI-11712923.; [SUBCELLULAR LOCATION] Secreted {ECO:0000269|PubMed:7644496}.; [MASS SPECTROMETRY] [Platelet factor 4]: Mass=7765; Method=Electrospray; Evidence={ECO:0000269|PubMed:7644496}.; [MASS SPECTROMETRY] [Platelet factor 4, short form]: Mass=6033; Method=Electrospray; Note=Short form.; Evidence={ECO:0000269|PubMed:7644496}.; [SIMILARITY] Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=CXCL4 entry; URL='https://en.wikipedia.org/wiki/CXCL4'. |
| Source Db |
UniProtKB: locus PLF4_HUMAN, accession P02776;; class: standard.; extra accessions:Q53X61,Q9UC64,Q9UC65; created: Jul 21, 1986.; sequence updated: Jul 1, 1989.; annotation updated: Oct 12, 2022.; xrefs: M25897.1, AAA60066.1, AF349466.1, AAK29643.1, CR407677.1, CAG28605.1, AC097709.3, AAY41003.1, BC093965.1, AAH93965.1, BC112093.1, AAI12094.1, PFHU4, NP_002610.1, 1DN3_A, 1F9Q_A, 1F9Q_B, 1F9Q_C, 1F9Q_D, 1F9R_A, 1F9R_B, 1F9R_C, 1F9R_D, 1F9S_A, 1F9S_B, 1F9S_C, 1F9S_D, 1PFM_A, 1PFM_B, 1PFM_C, 1PFM_D, 1PFN_A, 1PFN_B, 1PFN_C, 1PFN_D, 1RHP_A, 1RHP_B, 1RHP_C, 1RHP_D, 4R9W_A, 4R9W_B, 4R9Y_A, 4R9Y_B, 4R9Y_C, 4R9Y_D, 4RAU_C, 4RAU_F, 4RAU_I, 4RAU_L, 4RAU_O, 4RAU_R, 4RAU_U, 4RAU_X; xrefs (non-sequence databases): CCDS:CCDS3562.1, PDBsum:1DN3, PDBsum:1F9Q, PDBsum:1F9R, PDBsum:1F9S, PDBsum:1PFM, PDBsum:1PFN, PDBsum:1RHP, PDBsum:4R9W, PDBsum:4R9Y, PDBsum:4RAU, AlphaFoldDB:P02776, SMR:P02776, BioGRID:111219, DIP:DIP-56941N, IntAct:P02776, MINT:P02776, STRING:9606.ENSP00000296029, BindingDB:P02776, ChEMBL:CHEMBL3286075, DrugBank:DB00055, DrugBank:DB01109, PhosphoSitePlus:P02776, BioMuta:PF4, DMDM:130304, OGP:P02776, jPOST:P02776, MassIVE:P02776, PaxDb:P02776, PeptideAtlas:P02776, PRIDE:P02776, ProteomicsDB:51593, TopDownProteomics:P02776, ABCD:P02776, Antibodypedia:24586, DNASU:5196, Ensembl:ENST00000296029.4, Ensembl:ENSP00000296029.3, Ensembl:ENSG00000163737.5, GeneID:5196, KEGG:hsa:5196, MANE-Select:ENST00000296029.4, UCSC:uc003hhi.4, CTD:5196, DisGeNET:5196, GeneCards:PF4, HGNC:8861, HPA:ENSG00000163737, MIM:173460, neXtProt:NX_P02776, OpenTargets:ENSG00000163737, PharmGKB:PA33203, VEuPathDB:HostDB:ENSG00000163737, eggNOG:ENOG502TF57, GeneTree:ENSGT00940000163666, HOGENOM:CLU_143902_1_2_1, InParanoid:P02776, OMA:CAVPQLI, OrthoDB:1618797at2759, PhylomeDB:P02776, TreeFam:TF333433, PathwayCommons:P02776, Reactome:R-HSA-114608, Reactome:R-HSA-140875, Reactome:R-HSA-202733, Reactome:R-HSA-380108, Reactome:R-HSA-418594, Reactome:R-HSA-8936459, SignaLink:P02776, BioGRID-ORCS:5196, EvolutionaryTrace:P02776, GeneWiki:Platelet_factor_4, GenomeRNAi:5196, Pharos:P02776, PRO:PR:P02776, Proteomes:UP000005640, RNAct:P02776, Bgee:ENSG00000163737, Genevisible:P02776, GO:0062023, GO:0005737, GO:0005576, GO:0005615, GO:0031093, GO:0008009, GO:0045236, GO:0048248, GO:0008201, GO:0007189, GO:0061844, GO:0071222, GO:0070098, GO:0019221, GO:0042832, GO:0006954, GO:0051873, GO:0031640, GO:0030595, GO:0016525, GO:2001240, GO:0045653, GO:0045347, GO:0030593, GO:0030168, GO:0010628, GO:0010744, GO:0045651, GO:0045944, GO:0032760, GO:0042127, CDD:cd00273, InterPro:IPR001089, InterPro:IPR018048, InterPro:IPR001811, InterPro:IPR033899, InterPro:IPR036048, InterPro:IPR027222, PANTHER:PTHR10179, PANTHER:PTHR10179:SF38, Pfam:PF00048, PRINTS:PR00437, SMART:SM00199, SUPFAM:SSF54117, PROSITE:PS00471 |
| Sequence |
mssaagfcasrpgllflgllllplvvafasaeaeedgdlqclcvkttsqvrprhitslevikagphcptaqliatlkngrkicldlqaplykkiikklles |
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