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| Record Information |
| Record ID |
226 |
| Pubmed ID |
33244316 |
| SNP |
|
| Gene ID |
3627 |
| Protein ID |
P02778 |
| Vaccine Adverse Events |
fatigue, myalgia, chills,fatigue, headache,pruritus |
| Vaccine |
MVA-B vaccine |
| Gene Name |
CXCL10 |
| Official Symbol |
C-X-C motif chemokine ligand 10 [Homo sapiens (human)] |
| Aliases |
C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 |
| Other Designations |
C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; gamma IP10; interferon-inducible cytokine IP-10; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10; small-inducible cytokine B10 |
| Chromosome |
4 |
| Location |
4q21.1 |
| Annotation |
Chromosome 4 NC_000004.12 (76021118..76023497, complement) |
| MIM |
147310 |
| DNA Sequence |
>NC_000004.12:76021118-76023497 Homo sapiens chromosome 4, GRCh38.p14 Primary Assembly
TTAGTTATAATTACTTTATTAACCTTTTGATCTTTCAACATTTAGATAGTCTTTCTTAATATTTCCAGGA
GAGTACCTCATTTTTATTTTGAAAACCATTCAGCACATTTATCTTATGTAACATGCAGAGCATATATCTA
TCTGTATTTTTAAAATTTTCCTGTTACTCATTGATACATAGTACTTAATTACATGTTATTCCATGTACAC
TGAAAACAATATAGGAAATATATACATCTAAGACTTCTACTTTGTACAGTCTTTCATTAAATAAGAATAC
TTACACATACATTTTCAGATATTTCTACCTTCCTGTATGTGTTTGGAATTGTATGTAGGTAGCCACTGAA
AGAATTTGGGCCCCTTGGGAGGATGGCAGTGGAAGTCCATGAAGTAAAGAGCATTCTTTAAAAAGCAGAT
TTGATTGCATACCTTTTAGTTATTTGAGATTCTGAGAATTCTGATAAACCCCAAAGCAGAAAGATTCCTT
AGTACCCTTGGAAGATGGGAAAGGTGAGGGAAATATTTGAAGCAGGGTCAGAACATCCACTAAGAACATA
GCACCTCAGTAGAGCTTACATTATAGTGCCAGGGTAGAGTTATTACTGAATAGCTTAGGATGATGAACAT
TAACCTTCCTACAGGAGTAGTAGCAGCTGATTTGGTGACCATCATTGGTCACCTTTTAGTGTAACTGCAA
ACTAAGAACAATTATGGCTTGACATATACTCCATGTAGGGAAGTGATGGGAGAGGCAGCCTCTGTGTGGT
CCATCCTTGGAAGCACTGCATCGATTTTGCTCCCCTCTGGTTTTAAGGAGATCTTTTAGACCTGTAAGAA
GAGAAAGGGGATATAAAAGTGTGATAGTCTGACTCTGGCTTCAGATTGGGTTGTGTTTGGAAAGTACCGA
GTTCATAGAATAGATAACTGAGCTTTCCTGCTGCTATGCATTCATTATGGATTATAGGGGTTGCTTTTTT
CAACCATGAAAGACTTGGGGAAAATGTTGTCAGTTTTGCTTAGATAGTTATAGCTGTACTTCAAGGTTGA
CTGGTAATCAGGGTAACTTCTGATACTTATCACACAAGATGGTGCCTCAGCATTTAAATAAATGGAGGTA
GGGGAGGGCGTGGTGGTAACATACTTTTAAACCAGCGATTGCACAGCAAACCACAATGCAAGTATTTCTG
ACTCCCAAGATTGCCGTTTCCTAAAGAGCAATTCTTCTGCAGGCAACAGCAAACCTACCTTTCCTTGCTA
ACTGCTTTCAGTAAATTCTTGATGGCCTTCGATTCTGGATTCAGACATCTCTTCTCACCCTTCTTTTTCA
TTGTAGCACTGTAGAAATAAATAGGGATGAAAATATTTAAAACTGTGTTGGGTCAATAAAACAGATGGCA
TACGCAGTTCTGAAGTCAGACATTTAAGTTTCACTCTGCATGTTTTTGTTTGCTGTACATTAGTTTTAGA
ATCATCACAAACCCTTTACTGATCTTTTTTTATTATCATTACATATTTAATACAGTATATAATTACAACC
AGGGAAGTGATAATCAGATGGGATTTCACTCACATGATCTCAACACGTGGACAAAATTGGCTTGCAGGAA
TAATTTCAAGTTTTTCTAAAGACCTTGGATTAACAGGTTGATTACTAATGCTGATGCAGGTACAGCGTAC
AGTTCTAGAGAGAGGTACTCCTGTAGGAAAAGAGGAACAGCAGAGAAGGTTAGCACAGTGTTCATTTTAG
GCATTTAATGTAGACTGGTGGTATTTAGCAGAACCTATATCCCCATATCAGCAAATAGTCACTTAATCTG
AGGAGGAATGGATCACATCATAACACAACTGTAAATGATTAAAGAGTTGATTATCTGGAAGAAAAGAATT
GCAGCTTGTTGATTATAAAGTCAAACCCTTAAGCACAGTTCATGTGGTTCATTGAGCTTAGTTAGGTAAG
GAAGTATCTGTATCTCATCTCTGTCCGCATTCCCTCACATTTTCTCTCTCTATCCTCCCTCTTCCCCATC
TCTTCTGTCCTCCTTCCCTTTTTCCTTCTCTTTCTCTTATTCTATTTGTTTCTCTCACTTCAATTCATAT
AAGTTTTATGATCTGAGGGAATCTCTATTTATTTCCCTCTTATTTATAAGCATGCAGTGAAACTTTTACA
AATACATTATTTCTGTATTTTTAGAATTTATACCTATTCCTATTTCTCATTTTACAAATTAAGTATCCTT
TGATGTTCCTTACCTTGAATGCCACTTAGAGTCAGAAAGATAAGGCAGCAAATCAGAATGGCAGTTTGAT
TCATGGTGCTGAGACTGGAGGTTCCTCTGCTGTAGGCTCAGAATATGTCTAAGCAATTGAGGAATGTCTC
|
| Protein Name |
CXL10_HUMAN |
| Length |
98 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
21-JUL-1986 |
| Definition |
RecName: Full=C-X-C motif chemokine 10; AltName: Full=10 kDa interferon gamma-induced protein; Short=Gamma-IP10; Short=IP-10; AltName: Full=Small-inducible cytokine B10; Contains: RecName: Full=CXCL10(1-73); Flags: Precursor |
| Primary Accession |
P02778 |
| Accession Version |
P02778.2 |
| Other SeqIDs |
sp|P02778.2|CXL10_HUMAN,gi|21542456 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Mar 15, 2005 this sequence version replaced gi:72111, gi:124493.; [FUNCTION] Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity). {ECO:0000250|UniProtKB:P17515, ECO:0000269|PubMed:11157474, ECO:0000269|PubMed:12663757, ECO:0000269|PubMed:12750173, ECO:0000269|PubMed:19151743, ECO:0000269|PubMed:22652417, ECO:0000269|PubMed:7540647}.; [SUBUNIT] Monomer, dimer, and tetramer (PubMed:12737818). Interacts with CXCR3 (via N-terminus) (PubMed:19151743). {ECO:0000269|PubMed:12737818, ECO:0000269|PubMed:19151743}.; [INTERACTION] P02778; P51671: CCL11; NbExp=2; IntAct=EBI-7815386, EBI-727357; P02778; Q99616: CCL13; NbExp=2; IntAct=EBI-7815386, EBI-725342; P02778; O00585: CCL21; NbExp=2; IntAct=EBI-7815386, EBI-953695; P02778; Q9Y258: CCL26; NbExp=2; IntAct=EBI-7815386, EBI-7783416; P02778; Q9NRJ3: CCL28; NbExp=2; IntAct=EBI-7815386, EBI-7783254; P02778; P13501: CCL5; NbExp=2; IntAct=EBI-7815386, EBI-2848366; P02778; P48061: CXCL12; NbExp=2; IntAct=EBI-7815386, EBI-3913254; P02778; Q07325: CXCL9; NbExp=2; IntAct=EBI-7815386, EBI-3911467; P02778; P27487: DPP4; NbExp=2; IntAct=EBI-7815386, EBI-2871277; P02778; P02776: PF4; NbExp=2; IntAct=EBI-7815386, EBI-2565740.; [SUBCELLULAR LOCATION] Secreted {ECO:0000269|PubMed:21183794}.; [TISSUE SPECIFICITY] Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757). {ECO:0000269|PubMed:11157474, ECO:0000269|PubMed:12663757}.; [INDUCTION] By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.; [PTM] Several proteases can mediate post-secretion cleavages. DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10. This dominant negative form is capable of binding CXCR3 but does not induce signaling. MMP9 cleaves 9 amino acids instead. {ECO:0000269|PubMed:21183794}.; [MASS SPECTROMETRY] [C-X-C motif chemokine 10]: Mass=8641.8; Method=Electrospray; Evidence={ECO:0000269|PubMed:11559369}.; [SIMILARITY] Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=CXCL10 entry; URL='https://en.wikipedia.org/wiki/CXCL10'.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/CXCL10ID40218ch4q21.html'. |
| Source Db |
UniProtKB: locus CXL10_HUMAN, accession P02778;; class: standard.; extra accessions:Q96QJ5; created: Jul 21, 1986.; sequence updated: Jun 20, 2002.; annotation updated: Oct 12, 2022.; xrefs: X02530.1, CAA26370.1, BC010954.1, AAH10954.1, TGHUGI, NP_001556.2, 1LV9_A, 1O7Y_A, 1O7Y_B, 1O7Y_C, 1O7Y_D, 1O7Z_A, 1O7Z_B, 1O80_A, 1O80_B; xrefs (non-sequence databases): CCDS:CCDS43240.1, PDBsum:1LV9, PDBsum:1O7Y, PDBsum:1O7Z, PDBsum:1O80, AlphaFoldDB:P02778, SMR:P02778, BioGRID:109839, DIP:DIP-5893N, IntAct:P02778, MINT:P02778, STRING:9606.ENSP00000305651, BindingDB:P02778, ChEMBL:CHEMBL3712964, DrugBank:DB11338, DrugBank:DB06116, DrugBank:DB04487, iPTMnet:P02778, PhosphoSitePlus:P02778, BioMuta:CXCL10, DMDM:21542456, MassIVE:P02778, MaxQB:P02778, PaxDb:P02778, PeptideAtlas:P02778, PRIDE:P02778, ProteomicsDB:51594, ABCD:P02778, Antibodypedia:6335, CPTC:P02778, DNASU:3627, Ensembl:ENST00000306602.3, Ensembl:ENSP00000305651.1, Ensembl:ENSG00000169245.6, GeneID:3627, KEGG:hsa:3627, MANE-Select:ENST00000306602.3, UCSC:uc003hjl.5, CTD:3627, DisGeNET:3627, GeneCards:CXCL10, HGNC:10637, HPA:ENSG00000169245, MIM:147310, neXtProt:NX_P02778, OpenTargets:ENSG00000169245, PharmGKB:PA35568, VEuPathDB:HostDB:ENSG00000169245, eggNOG:ENOG502S7MM, GeneTree:ENSGT00940000161759, HOGENOM:CLU_143902_2_2_1, InParanoid:P02778, OMA:RNIRCRC, OrthoDB:1548456at2759, PhylomeDB:P02778, TreeFam:TF333433, PathwayCommons:P02778, Reactome:R-HSA-380108, Reactome:R-HSA-418594, Reactome:R-HSA-6783783, SignaLink:P02778, SIGNOR:P02778, BioGRID-ORCS:3627, ChiTaRS:CXCL10, EvolutionaryTrace:P02778, GeneWiki:CXCL10, GenomeRNAi:3627, Pharos:P02778, PRO:PR:P02778, Proteomes:UP000005640, RNAct:P02778, Bgee:ENSG00000169245, Genevisible:P02778, GO:0009897, GO:0005576, GO:0005615, GO:0008603, GO:0042056, GO:0008009, GO:0045236, GO:0048248, GO:0008201, GO:0005102, GO:0007189, GO:0061844, GO:0140374, GO:0008015, GO:0007166, GO:0007267, GO:0034605, GO:0097398, GO:0071222, GO:0098586, GO:0070098, GO:0006935, GO:0042118, GO:0007186, GO:0006954, GO:0031640, GO:0007517, GO:0016525, GO:0045662, GO:1901740, GO:0030593, GO:0008284, GO:0090026, GO:0051281, GO:2000406, GO:0045944, GO:0042981, GO:0042127, GO:1901509, GO:0010819, GO:0010996, GO:0009409, GO:0010332, GO:0033280, GO:0007165, GO:0010818, CDD:cd00273, InterPro:IPR001089, InterPro:IPR018048, InterPro:IPR001811, InterPro:IPR033899, InterPro:IPR036048, PANTHER:PTHR10179, Pfam:PF00048, PRINTS:PR00437, SMART:SM00199, SUPFAM:SSF54117, PROSITE:PS00471 |
| Sequence |
mnqtailicclifltlsgiqgvplsrtvrctcisisnqpvnprslekleiipasqfcprveiiatmkkkgekrclnpeskaiknllkavskerskrsp |
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