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| Record Information |
| Record ID |
220 |
| Pubmed ID |
29920186 |
| SNP |
|
| Gene ID |
3605 |
| Protein ID |
Q16552 |
| Vaccine Adverse Events |
|
| Vaccine |
acellular pertussis vaccines |
| Gene Name |
IL17A |
| Official Symbol |
interleukin 17A [Homo sapiens (human)] |
| Aliases |
CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17 |
| Other Designations |
interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin-17 |
| Chromosome |
6 |
| Location |
6p12.2 |
| Annotation |
Chromosome 6 NC_000006.12 (52186375..52190638) |
| MIM |
603149 |
| DNA Sequence |
>NC_000006.12:52186375-52190638 Homo sapiens chromosome 6, GRCh38.p14 Primary Assembly
GTCCATCTCATAGCAGGCACAAACTCATCCATCCCCAGTTGATTGGAAGAAACAACGATGACTCCTGGGA
AGACCTCATTGGTGGTGAGTCCTGCACTAACGTGCGATGCTCTTGCTGATTTGGACCAGATAGTATTTCT
GGACCGTGGGCATGAAACGCTGGGTTCTGACTATGGAGATCCAGGAATACTGTATATGTAGGATAGGAAA
TGAAAGCTTTGGTAGGTATTTAAGTCATTGTGCAGCATTTTCAAGAACTGATACACAGCAGTTTGAAAGA
TAAGATTAAAACTGAAAGATAGCTATATTGGGGCTAAACCACACAAGAAGTGTCACATGATGCTGTGCAG
TAAGAAAGAAAATTTATTGAAAGTCTGTTTTTCTGAGTACAAAGGATTTAATATAATTCTCCCACGGCAT
TTTTCTTTAAAATGGGTCACTATCCTTGAGATTTTGAAAGCCGTAGCAGCAACAACCTTTGTTTCCATTA
TCTCGTACCATATTCTCAGTACATTGAAACTATGTATTCTAACTAAACATAGGTATAACTGTGTTTTAGA
ATAAGTGGGGTTTATATTTTTTAAATATTTAACTTCAAGTATCTTTTTTGAAATCTGATTTTATTACAGA
ATCAATACATGTTAAATTTAGAACAACTGGAAAATATACCTAAGAAAACATGAAGGAGATCGAGTTTTTA
GTTGGATGCCTGCCAGTAGCACCAACAGCACTTCTAGCATGAATATTGATACCACATAGATTTTCTATAG
CTCTTTCTTCCAATGTGAATGTTTGACTTCACGATGAGTTTCACAGAATATGGGACTGAGAACAATGGTG
CAGGAGGATATTTCTACCTAGAAAATCAAGGTTATTATTCCTTCCCAGACCTGACAATGATGCATGTGCT
GATAGGCTAATGACATGCCATGACTTGACATTTTTATTAAAATTATTGCCAACCAATGGATAACATGTCT
TTCCTAAGTCAAAAGGAGAATGTTGAAACTAGTTTTTTTAAAAAAATTTTAAAGCCATGGTGTTAACATT
ATGTTGGTCATCTACCTAGATTTTTCTCTAGCTGATCTGAAAAATGTAGTATAGATTGTCCTGGAACATT
GTGTGTTCTCTATGATTAGCAATGCATCATCATCACAATTAATTTGTCAAAAAGAACCACATAGTAATCT
AATCTCCAACCTCTCTCTCCTTTCCCATTCAATTCTAGTCACTGCTACTGCTGCTGAGCCTGGAGGCCAT
AGTGAAGGCAGGAATCACAATCCCACGAAATCCAGGATGCCCAAATTCTGAGGACAAGAACTTCCCCCGG
ACTGTGATGGTCAACCTGAACATCCATAACCGGAATACCAATACCAATCCCAAAAGGTCCTCAGATTACT
ACAACCGATCCACCTCACCTTGGAATCTCCAGTACGTAAAGCTTCCAGATAAAAATGCTATATTCTTCAT
CCCTCTTATGCATCAGACTGCCAGTTAAATCTCCCTGAGGATGATTTTATTCATTTAGAATTACCAGTCA
AACCTGGAAGGACCACTGTGAAGAGCAATTCTCAAACTTTCTACAGATTTCTTTAACCAAGCACAGGACA
GCCTCCAATAATCCCTATCCTGTTAGATCTAATTGTCACTGACACCAATAATCAACCCAAATTAATTATA
ATCATTATTCTAATATTTATGAGACCCCAAGTCTATTCTTTATTTATTCAAAGAATAGACATTTATCAAA
GAGGATTAATGCTTTTATTATCTTAACCAGAGCTGCCATTGAGAAGATTTATTGCAAATAATTAATAATT
AGGGTTTTTTACTTTTATTCTTTTGCTTATTTTTGTTTTTGAATCCCAGTGGAATAAGTATCACTGGGGT
ATTTCTACCCCTTTGTGTGTTAAATAGTCTTGATCTACTTCCTAACATACCTATGCTTGCTGTATCCTTA
GTATACCCAGTATTTAGACCCCATCAAGGGTTAAATACCAAATGTATTTTGATCATTTGACTTCATACAA
ATAAGTCTCTGTTCTGTGGAGCCTACAGATTGGTCTGATTGTAGGATTTCTTCTCTTCTTCCCATTACTA
GGAAGAGTCAAAATAAATCAATTCAAAAATGCAAGCAAATCATTCACTGATCTAAAAGAGAGAGGGAAGA
GAAGGTCATAGAGACACTTAACCTTTTGTTTCCAGCCCTTTATCTCAGCTCTGGGCTCTGTCCCACGAAT
GTGATCTCAGATAAAATTTTGATGTATTCCCTCTTCAAAGACAGACTTCATCAAGTCAAATAAACAGCTA
TCTTATTCTAGATGGTTCCAAGTCTACTCTTCCTTTGGTCTTCTTCTGTCTGTCAAATGTACCCTAAAAA
AGCTATCATTTGTGTCAAACTTAAATTTTTTCTGTGGCCTCAGTCTATCTTATTTTATTCATTCTTCAAA
TAAATTGGAGAAAAACTGATCACTGTCTTCTTTTCTATAACAATTCACGTGCTTGAAAAAAAAATCCAAT
TTGTCCCCAAAGTTCTTCTTCAAACTAACATCATTTAAAGAATTTGCAATGCCTATAATTTGTCATCCTG
TGAACTTGCCTCTCTTCATGTATTCCTGTTTTATTTCTTTCCCACTTTACCAGGAATTCACTTTCCTCCT
GATTTTTCTCCCCTCTGCAGCCGCAATGAGGACCCTGAGAGATATCCCTCTGTGATCTGGGAGGCAAAGT
GCCGCCACTTGGGCTGCATCAACGCTGATGGGAACGTGGACTACCACATGAACTCTGTCCCCATCCAGCA
AGAGATCCTGGTCCTGCGCAGGGAGCCTCCACACTGCCCCAACTCCTTCCGGCTGGAGAAGATACTGGTG
TCCGTGGGCTGCACCTGTGTCACCCCGATTGTCCACCATGTGGCCTAAGAGCTCTGGGGAGCCCACACTC
CCCAAAGCAGTTAGACTATGGAGAGCCGACCCAGCCCCTCAGGAACCCTCATCCTTCAAAGACAGCCTCA
TTTCGGACTAAACTCATTAGAGTTCTTAAGGCAGTTTGTCCAATTAAAGCTTCAGAGGTAACACTTGGCC
AAGATATGAGATCTGAATTACCTTTCCCTCTTTCCAAGAAGGAAGGTTTGACTGAGTACCAATTTGCTTC
TTGTTTACTTTTTTAAGGGCTTTAAGTTATTTATGTATTTAATATGCCCTGAGATAACTTTGGGGTATAA
GATTCCATTTTAATGAATTACCTACTTTATTTTGTTTGTCTTTTTAAAGAAGATAAGATTCTGGGCTTGG
GAATTTTATTATTTAAAAGGTAAAACCTGTATTTATTTGAGCTATTTAAGGATCTATTTATGTTTAAGTA
TTTAGAAAAAGGTGAAAAAGCACTATTATCAGTTCTGCCTAGGTAAATGTAAGATAGAATTAAATGGCAG
TGCAAAATTTCTGAGTCTTTACAACATACGGATATAGTATTTCCTCCTCTTTGTTTTTAAAAGTTATAAC
ATGGCTGAAAAGAAAGATTAAACCTACTTTCATATGTATTAATTTAAATTTTGCAATTTGTTGAGGTTTT
ACAAGAGATACAGCAAGTCTAACTCTCTGTTCCATTAAACCCTTATAATAAAATCCTTCTGTAATAATAA
AGTTTCAAAAGAAAATGTTTATTTGTTCTCATTAAATGTATTTTAGCAAACTCAGCTCTTCCCTATTGGG
AAGAGTTATGCAAATTCTCCTATAAGCAAAACAAAGCATGTCTTTGAGTAACAATGACCTGGAAATACCC
AAAATTCCAAGTTCTCGATTTCACATGCCTTCAAGACTGAACACCGACTAAGGTTTTCATACTATTAGCC
AATGCTGTAGACAGAAGCATTTTGATAGGAATAGAGCAAATAAGATAATGGCCCTGAGGAATGGCATGTC
ATTATTAAAGATCATATGGGGAAAATGAAACCCTCCCCAAAATACAAGAAGTTCTGGGAGGAGACATTGT
CTTCAGACTACAATGTCCAGTTTCTCCCCTAGACTCAGGCTTCCTTTGGAGATTAAGGCCCCTCAGAGAT
CAACAGACCAACATTTTTCTCTTCCTCAAGCAACACTCCTAGGGCCTGGCTTCTGTCTGATCAAGGCACC
ACACAACCCAGAAAGGAGCTGATGGGGCAGAACGAACTTTAAGTATGAGAAAAGTTCAGCCCAAGTAAAA
TAAAAACTCAATCACATTCAATTCCAGAGTAGTTTCAAGTTTCACATCGTAACCATTTTCGCCC
|
| Protein Name |
IL17_HUMAN |
| Length |
155 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-NOV-1997 |
| Definition |
RecName: Full=Interleukin-17A; Short=IL-17; Short=IL-17A; AltName: Full=Cytotoxic T-lymphocyte-associated antigen 8; Short=CTLA-8; Flags: Precursor |
| Primary Accession |
Q16552 |
| Accession Version |
Q16552.1 |
| Other SeqIDs |
sp|Q16552.1|IL17_HUMAN,gi|2498481 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Nov 27, 2009 this sequence version replaced gi:74744650.; [FUNCTION] Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361). Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:19825828, PubMed:21350122, PubMed:17911633, PubMed:18684971, PubMed:8676080, PubMed:24120361). Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (By similarity). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (By similarity). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection (PubMed:21350122). Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms (By similarity). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). {ECO:0000250|UniProtKB:Q62386, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:8676080}.; [SUBUNIT] Homodimer (PubMed:19835883). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (PubMed:32187518). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex (PubMed:32187518). IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (PubMed:23695682). Heterodimer with IL17F (PubMed:17355969). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (PubMed:32187518). IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:17355969, PubMed:28827714). {ECO:0000269|PubMed:17355969, ECO:0000269|PubMed:19835883, ECO:0000269|PubMed:23695682, ECO:0000269|PubMed:28827714, ECO:0000269|PubMed:32187518}.; [INTERACTION] Q16552; Q9BQC3: DPH2; NbExp=3; IntAct=EBI-10237926, EBI-10237931; Q16552; Q6PIL6: KCNIP4; NbExp=3; IntAct=EBI-10237926, EBI-1051469.; [SUBCELLULAR LOCATION] Secreted {ECO:0000269|PubMed:17763419, ECO:0000269|PubMed:8676080}.; [TISSUE SPECIFICITY] Expressed in memory Th17 cells (at protein level). {ECO:0000269|PubMed:17763419}.; [INDUCTION] Induced upon differentiation of CD4-positive T cells. Up-regulated by IL23A-IL12B (PubMed:17763419). Up-regulated in peripheral blood mononuclear cells upon West Nile virus infection (PubMed:27795421). {ECO:0000269|PubMed:17763419, ECO:0000269|PubMed:27795421}.; [PTM] N-glycosylated. Found both in glycosylated and nonglycosylated forms. {ECO:0000269|PubMed:8676080}.; [SIMILARITY] Belongs to the IL-17 family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-17 entry; URL='https://en.wikipedia.org/wiki/Interleukin_17'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il17/'.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/IL17AID40945ch6p12.html'. |
| Source Db |
UniProtKB: locus IL17_HUMAN, accession Q16552;; class: standard.; extra accessions:Q5T2P0; created: Nov 1, 1997.; sequence updated: Nov 1, 1996.; annotation updated: Oct 12, 2022.; xrefs: Z58820.1, CAA91233.1, U32659.1, AAC50341.1, AY460616.1, AAR23263.1, AL391221.15, CH471081.1, EAX04362.1, BC066251.1, AAH66251.1, BC066252.1, AAH66252.1, BC067503.1, AAH67503.1, BC067504.1, AAH67504.1, BC067505.1, AAH67505.1, NP_002181.1, 2VXS_A, 2VXS_B, 2VXS_C, 2VXS_D, 4HR9_A, 4HR9_B, 4HSA_A, 4HSA_B, 4HSA_D, 4HSA_E, 4QHU_C, 4QHU_D, 5HHV_A, 5HHV_B, 5HHX_A, 5HHX_B, 5HI3_A, 5HI3_B, 5HI4_A, 5HI4_B, 5HI5_A, 5HI5_B, 5N7W_X, 5N7W_Y, 5N92_A, 5NAN_A, 5NAN_D, 5VB9_A, 5VB9_B, 6WIO_C, 6WIR_C, 7WKX_E, 7WKX_F; xrefs (non-sequence databases): CCDS:CCDS4937.1, PDBsum:2VXS, PDBsum:4HR9, PDBsum:4HSA, PDBsum:4QHU, PDBsum:5HHV, PDBsum:5HHX, PDBsum:5HI3, PDBsum:5HI4, PDBsum:5HI5, PDBsum:5N7W, PDBsum:5N92, PDBsum:5NAN, PDBsum:5VB9, PDBsum:6WIO, PDBsum:6WIR, PDBsum:7WKX, AlphaFoldDB:Q16552, SMR:Q16552, BioGRID:109818, DIP:DIP-6014N, IntAct:Q16552, STRING:9606.ENSP00000344192, BindingDB:Q16552, ChEMBL:CHEMBL3390822, DrugBank:DB11569, DrugBank:DB09029, DrugCentral:Q16552, GlyGen:Q16552, iPTMnet:Q16552, PhosphoSitePlus:Q16552, BioMuta:IL17A, DMDM:2498481, PaxDb:Q16552, PeptideAtlas:Q16552, PRIDE:Q16552, ProteomicsDB:60910, ABCD:Q16552, Antibodypedia:17132, DNASU:3605, Ensembl:ENST00000648244.1, Ensembl:ENSP00000497968.1, Ensembl:ENSG00000112115.7, GeneID:3605, KEGG:hsa:3605, MANE-Select:ENST00000648244.1, UCSC:uc003pak.1, CTD:3605, DisGeNET:3605, GeneCards:IL17A, HGNC:5981, HPA:ENSG00000112115, MIM:603149, neXtProt:NX_Q16552, OpenTargets:ENSG00000112115, PharmGKB:PA29794, VEuPathDB:HostDB:ENSG00000112115, eggNOG:ENOG502S5A0, GeneTree:ENSGT00940000161882, HOGENOM:CLU_118641_0_0_1, InParanoid:Q16552, OMA:HHMNSVP, OrthoDB:1469254at2759, PhylomeDB:Q16552, TreeFam:TF314701, PathwayCommons:Q16552, Reactome:R-HSA-448424, Reactome:R-HSA-6785807, Reactome:R-HSA-9705671, SignaLink:Q16552, SIGNOR:Q16552, BioGRID-ORCS:3605, EvolutionaryTrace:Q16552, GeneWiki:IL17A, GenomeRNAi:3605, Pharos:Q16552, PRO:PR:Q16552, Proteomes:UP000005640, RNAct:Q16552, Bgee:ENSG00000112115, Genevisible:Q16552, GO:0009897, GO:0005576, GO:0005615, GO:0005125, GO:0046982, GO:0042803, GO:0002250, GO:0006915, GO:0008219, GO:0007267, GO:0071347, GO:0050832, GO:0050829, GO:0050830, GO:0072537, GO:0097530, GO:0006955, GO:0006954, GO:0045087, GO:0097400, GO:0060729, GO:0007219, GO:0002225, GO:1903348, GO:2000340, GO:1900017, GO:0032731, GO:0032735, GO:0032739, GO:0032747, GO:0032755, GO:0045672, GO:0045944, GO:0032760, Gene3D:2.10.90.10, InterPro:IPR029034, InterPro:IPR020440, InterPro:IPR010345, Pfam:PF06083, PRINTS:PR01932, SUPFAM:SSF57501 |
| Sequence |
mtpgktslvslllllsleaivkagitiprnpgcpnsedknfprtvmvnlnihnrntntnpkrssdyynrstspwnlhrnedperypsviweakcrhlgcinadgnvdyhmnsvpiqqeilvlrrepphcpnsfrlekilvsvgctcvtpivhhva |
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