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| Record Information |
| Record ID |
217 |
| Pubmed ID |
29920186 |
| SNP |
|
| Gene ID |
3578 |
| Protein ID |
P15248 |
| Vaccine Adverse Events |
|
| Vaccine |
acellular pertussis vaccines |
| Gene Name |
IL9 |
| Official Symbol |
interleukin 9 [Homo sapiens (human)] |
| Aliases |
HP40, IL-9, P40 |
| Other Designations |
interleukin-9; T-cell growth factor p40; cytokine P40; homolog of mouse T cell and mast cell growth factor 40; p40 T-cell and mast cell growth factor; p40 cytokine |
| Chromosome |
5 |
| Location |
5q31.1 |
| Annotation |
Chromosome 5 NC_000005.10 (135892246..135895841, complement) |
| MIM |
146931 |
| DNA Sequence |
>NC_000005.10:135892246-135895841 Homo sapiens chromosome 5, GRCh38.p14 Primary Assembly
ATTTATTTCAAAATAAAGACATACAATGTTAAACAAATAATCACAACTGATACTGATTTAGAGTAGCTTA
CTTGATTTTTAAATTGTAGCAACTTAAAGAGAAAGCTTTTTAAATTTAATAAATAGGATAAATAATATTT
CATCTTCATATCTTGCCTCTCATCCCTCTCATCTTTTCTTTCTGGAAAATTTCCAGAAGACTCTTCAGAA
ATGTCAGCGCGTTGCCTGCCGTGGTTTGGTTGCATGGCTGTTCACAGGAAAAATACTGTGGGGATGAAAG
TTGATAAGGACAGAGTGACTCAAATGATGTAGAGCCAAGCAGCCCCAGAAGCCTACCTGCCAAGAGCCAG
AGTCGGTGGTGAGGATTGTGGGGATGGGAAGGGAAGTGGCTTGAGACACAGAGCAAATAGGTGGGCAGGT
CCAGGCTAGCTCATGTGGTGTAAAGACAGCATAGGTGGTTGACCTCAAATTGGATTTCAGGGGTCTTTAC
ACACACACACACACACACACACACACACACACACACACACACACCCCTATTAAGTGGCCCTAAATCTCTG
CATTAGAGAAAGCCTTTTCTGGGGACTCTTTGAGGCCTAAAATTGTATCATTATCCTTTTAGGTTGTCTT
TCCAAGGTCATTTGACAGTACAATGGCTAAGAGTGGGGCTCTGAGGTCATATAGGCCTGAGTTCAAATCT
CAGCTCTGCCACTTATCAAATATGCAGCCTTAGGCAAATTAGTTAACCTCACTGAGAGTAATAAATTGAA
TAATTGTCCCTAAGGTATGTATTTATTCAGTGAGACAGCATATATTAAGCACTTAGAACTAGATGCCATT
GATGGTAGAAACGCATGCAGCTAAACAGCTGAGCTCAGGGCTTTCAGCCTTCTAGGATCTTGTGTGGAGA
TGCTAATACCCAAAAAACAGAGGGAGGTCACCTCTACCCAACTTGCCATCCCAGTCTGCTGTCAGGGACT
AGGGTATATGCTGAAGAAAAGAATGTGTGGATGGGCATTCAGGATGAGTAGCAAGCTTCCACCTTGACCT
GGGTGCATTGCCCTTTAAATACCTCCTTAATGCAGGCCAGGCATGGTGGCTCACACCTGTCATCCCAGCA
CTTTGGGAGGTCAAGGCGGGCAAATCACTTGAGTTCAGGAGTTGGAGAGCAACCTGGCCAACATGGTGAA
ACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCATGGTGGCACGCACCTGTAATGCCAGCTACTCG
GGAGGCTGAGGCAGGATAATCACTTGAACCCGGGAGGCAGAGGCTGCAGTGAGCTCAGATGGCACCACTG
CACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAACCTCCTTAACCAACAGGAA
AAAAAAATCCCTGTTAACAACATCCATTCAGTTAGTACATTGAATCTCTAGGATAATTTAGTATTATGTG
AGCTACATCCCTGATTCTCTAGATTGTAGCTTCTAATTACACTCAGAAAGGATTCTTTCATTATTCCATA
GTAGAGAGAAGTAAATGGCCTCGTCAGGAACAATGATCTATCTCACTTTAATTCTATTGTTTCAGTGGAT
CTCACTTTAATTATATTACTTCTGATTAAAATTCTTAGATGTCTTTTATCAACCTTGAACTACCAATTCC
AACTTTATCATCCTTTTGTGTTCAAACAGGGTTGGCATCACCATTCACATAGAAATCACCAACAGGAACA
TATCACATATGAAAACAAACTTACTGGACACTTGTTGTTCTTTAGTACTTCAACTGATTTTTTCACCCGA
CTGAAAATCAGTGGGTATCTTGTTTGCATGGTGGTATTGGTCATCTGAGACAGTCTCTCACTGAAGCATG
GTCTGGTGCAGTTGTCCTGGTAAATAGTAAGGATTTATTCAAAGAAATATTCTGAGGACAGCTTTGGAAA
TATATCACAAAGAGCAATATAATAGAGATGATTTTTATTTAATCACCATTACTCAAACTTGCATTATTTT
TAGACAGGTCCCTTGCCAATGTAGGAAGTGATCTCCCGTATTTAAAGGGGATGCCATTTTTCCACAGTGA
CATCCCCTGGAGGAGACTTCCTGTATGTTACATCCAGGAAACATGAGGGCTCTGGGCCCTGAAATAGTCG
GCTCTGAATGTTCTTTTCAACGGGTGCTTCCCGGCTTCAAGGCTTGTAAGTCTGAAAGTGCAGAGTGAGG
AAAAGCCTTTTCACACCAGCTAATGGGATGTGACAATTGAATGCAGCTGGTATTTCAGCAGCAGCTAAAA
ACATGGACGGTACTCCAAGGGACAGGGGCTGTGCTGTCTGCCTGGTTCCTGCCCAGAAGGCACTCTATCC
TCTTCTCATCTAATGGATGGACCGCGATGGGTGCGATGTCTTACCCTAGCCAGGGCAAGAAGCTCAGATT
CTTCAGATTCTCCCAGGCCTTGCATGAGAAAGAATAAAGCACTGCACCTTGGAGAAGTGCCTCCTCCTCA
CCCTAACCAGGAGTTTGAATTAGGAATCAGAACTTTCCTGCCACCCATCCTTCCTGCCGTAGTGGGCAGT
GGCCCTCTGGAAGCCCTCCTTCCACTCACAACCTCAGATCCTCTACCTGCCCAGAGGGCAGCATTCAAAC
CAACAGTCACTCTAATCAGCTAGACAGACAACAGGGTGGTGGGGAGGAAGGGAGGAGGCAGGGAGGGGGA
GGTATAGCGCATAGATCATTCATGACAGATGAAAGATAAGGAGTTGTCATTTTATTTACATTGTTTCACA
ACTCTAGAGTTATCAGTAAATGAGTTAGAAAGCAATATGATATGAGCTACAGCAATTATTATATCCTTAG
TTCCAGTTTTATTTAATTGTGCACATGGCCACCTATCTAAAAAGATATTCAGGATTCTTTTTTTAATGTT
GAAAAGTGTTCAAACTTCTCAAGAGGCATAAAGTTAATTAAATACAAAGAAATGTTCATAATATAGGATT
TCAAGATCGTAGTTTTAAAAGGGAATAATTTGTAACAATGTGGTTTTAACAGGGAATACTAATCTGTAAC
AATTAAATTAAGCAACAATGTATAACATTAAATATTAAATAAAGCAACTTATTTTTACTTAAAAACAAAC
CAAAAAAATCCAAGGTCAACATTATGTTATTTCACTATACTTACAGAGGGAATGCCCAAACAGAGACAAC
TGGTCACCTGCAAGGGAAATTTCAGAGTGAAGATTCCAGATGTGAAAATTAAAATTAATTTGGAAAGTTC
TTAAAGAGCATTCACTCACATTAGCACTGCAGTGGCACTTGGAAGCTGGATCTTCCTAAAGTAGATAGAG
AGATAAGAACCTTTAGTCAGCCCCGAGTTTTTTCATCCTCATACATATTTCACTTTGTCAGTAGCTGTCT
TTCCCATGGGCTCCCCCTGCAGCCTACCTGCATCTTGTTGATGAGGAAGTTGATGTCCAGGATCCCCGCC
AAGGTTGGACACCCCTGGCCTGCCACGGAGCACAGGAGCAGGGCAGAGGTAAGGACCATGGCCAGAAGCA
TCTTGACAGCGGACTGGAGCTCGCTT
|
| Protein Name |
IL9_HUMAN |
| Length |
144 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-APR-1990 |
| Definition |
RecName: Full=Interleukin-9; Short=IL-9; AltName: Full=Cytokine P40; AltName: Full=T-cell growth factor P40; Flags: Precursor |
| Primary Accession |
P15248 |
| Accession Version |
P15248.1 |
| Other SeqIDs |
sp|P15248.1|IL9_HUMAN,gi|124362 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Mar 15, 2005 this sequence version replaced gi:280860.; [FUNCTION] Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:29742432). Affects intestinal epithelial permeability and adaptive immunity (PubMed:29742432). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5. {ECO:0000250|UniProtKB:P15247, ECO:0000269|PubMed:29742432}.; [SUBUNIT] Interacts with IL9R. Interacts with IL2RG. {ECO:0000250|UniProtKB:P15247}.; [SUBCELLULAR LOCATION] Secreted.; [SIMILARITY] Belongs to the IL-7/IL-9 family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-9 entry; URL='https://en.wikipedia.org/wiki/Interleukin_9'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il9/'. |
| Source Db |
UniProtKB: locus IL9_HUMAN, accession P15248;; class: standard.; created: Apr 1, 1990.; sequence updated: Apr 1, 1990.; annotation updated: Oct 12, 2022.; xrefs: M30134.1, AAA36400.1, X17543.1, CAA35581.1, S63356.1, AAB19823.1, M30135.1, AAA35887.1, M86593.1, AAA59161.1, AF361105.1, AAK26666.1, AC002428.1, AAB66904.1, AC004763.1, AAC17735.1, BC066283.1, AAH66283.1, BC066285.1, AAH66285.1, BC066286.1, AAH66286.1, A60480, NP_000581.1; xrefs (non-sequence databases): CCDS:CCDS4189.1, AlphaFoldDB:P15248, BioGRID:109792, DIP:DIP-3155N, STRING:9606.ENSP00000274520, ChEMBL:CHEMBL3712932, GlyGen:P15248, iPTMnet:P15248, PhosphoSitePlus:P15248, BioMuta:IL9, DMDM:124362, PaxDb:P15248, PRIDE:P15248, ABCD:P15248, Antibodypedia:14762, DNASU:3578, Ensembl:ENST00000274520.2, Ensembl:ENSP00000274520.1, Ensembl:ENSG00000145839.2, GeneID:3578, KEGG:hsa:3578, MANE-Select:ENST00000274520.2, UCSC:uc003lbb.1, CTD:3578, DisGeNET:3578, GeneCards:IL9, HGNC:6029, HPA:ENSG00000145839, MIM:146931, neXtProt:NX_P15248, OpenTargets:ENSG00000145839, PharmGKB:PA29845, VEuPathDB:HostDB:ENSG00000145839, eggNOG:ENOG502TDE1, GeneTree:ENSGT00390000015384, HOGENOM:CLU_150120_0_0_1, InParanoid:P15248, OMA:CPFFSCE, OrthoDB:1444257at2759, PhylomeDB:P15248, TreeFam:TF336367, PathwayCommons:P15248, Reactome:R-HSA-8985947, SignaLink:P15248, SIGNOR:P15248, BioGRID-ORCS:3578, GeneWiki:Interleukin_9, GenomeRNAi:3578, Pharos:P15248, PRO:PR:P15248, Proteomes:UP000005640, RNAct:P15248, Bgee:ENSG00000145839, Genevisible:P15248, GO:0005576, GO:0005615, GO:0005125, GO:0008083, GO:0005140, GO:0030183, GO:0042100, GO:0016064, GO:0006954, GO:2001268, GO:0030307, GO:0008284, GO:0032754, GO:0050730, GO:0046425, InterPro:IPR018049, InterPro:IPR020447, PANTHER:PTHR16926, PRINTS:PR01926, PROSITE:PS00255 |
| Sequence |
mllamvltsalllcsvagqgcptlagildinflinkmqedpaskchcsanvtsclclgipsdnctrpcfserlsqmtnttmqtryplifsrvkksvevlknnkcpyfsceqpcnqttagnaltflkslleifqkekmrgmrgki |
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