|
|
| Record Information |
| Record ID |
216 |
| Pubmed ID |
29920186 |
| SNP |
|
| Gene ID |
3596 |
| Protein ID |
P35225 |
| Vaccine Adverse Events |
|
| Vaccine |
acellular pertussis vaccines |
| Gene Name |
IL13 |
| Official Symbol |
interleukin 13 [Homo sapiens (human)] |
| Aliases |
IL-13, P600 |
| Other Designations |
interleukin-13 |
| Chromosome |
5 |
| Location |
5q31.1 |
| Annotation |
Chromosome 5 NC_000005.10 (132656522..132661110) |
| MIM |
147683 |
| DNA Sequence |
>NC_000005.10:132656522-132661110 Homo sapiens chromosome 5, GRCh38.p14 Primary Assembly
ACGCGCGGGGGCGCCCCTGCCCACCGCTCCCGGCAGGGCTTTTGGTGGCCATGGGGGATAAGGGGCGTTG
ACTCACCCGGGCGGGGCTCCGGGAGTTGCACAGACCAAGGTAGTTCCCCGCTCCTTCCCCCATCACGGAG
ACCCTGTGGGAGATGCCGTGGGCCCTCTACTACAGATTAGGAAACAGGCCCGTAGAGGGGTCACACGGCC
AAGTAGCGGCACTCCAGGCACTGGGGGCCCTCGAGGGGAAGGGGCAGACTTCTGGGAGTCAGAGCCAGCA
GCTGGGCTGGGAAGCTTCGAGTGTGGACAGAGAGGGTGGGAATGACGTTCCCTGTGGGAAGAGAGGGTGG
GCAAGCCTGGGATGCCTCTGAGCGGGAATCCAGCATGCCTTGTGAGGAGGGTCACAAGCACACCCTTGTG
AGGAGGTTGAGCCCCATCGAGGACAGGACGGAGGGAGCCTGAGCAGGCAGAGAGGGGGCCTGGGGAGGCG
CTGGTTCGGGGAGGAAGTGGGTAGGGGAGAAATCTTGACATCAACACCCAACAGGCAAATGCCGTGGCCT
CTGCTGTGGGGGTTTCTGGAGGACTTCTAGGAAAACGAGGGAAGAGCAGGAAAAGGCGACATGGCTGCAG
GGGCCAAGCCCAGGAGCCGCCCTCCACAGCACTCATTCTGCAGAAGGGAAATTTGAGGCCCCCAGACGGC
AGGGGTTGATCCTGCAGAGACTGGTGAGCAAAGGGGATCACCCCAAGCCCCAGTGGCACTAGGAACACTT
ACAATCTCTGACCTGGACTAAGGCTGCCAGCCTGGCCCAGTTAAGAGTTTCCCAGAAGGATGGCCCATAC
ACTTTAAATTAAAGGGGCCAGACACGTGCACACTACTTCCAGCCACTCTGGAAGCTGAGGTGGGGGGATC
GCTTGAGTCTGGGAGTTGGAGGCCAGCCTAGGCAGGCAACATAGTGAGACCCCATCTCCAAAAAAACAAA
ACAAAACAAAACAAAAAAACACCAAAAAAGCTCCCAGAAAGACCTCTGAATCTTTCTGGATCTCTCAGTG
GAGACCTGGAAATCTGAACTTTGACAATCCCTCTCACAGTGGGGCCAAGGAGGAATTAGGCAAGCCAAAA
GAAGTGAACTTTACTCTTCTATTGCCTGTTTGAATTTTGTATCCAAGCAAGTGTTACTTAAGTAATTTAA
GAGACTGGTTCATCGAAAAAATAAAACTCCCCAAATTCCCATAGCTGGTAGACTGTGGTCACAGCCACAG
TGCACTAAGACTATCTGCTCAGCACTTCTGGTGACCCAAAAGGGTCTGAGGACAGGAGCTCAGAGTTGGG
TCAGCTGTCCAGGTACTCAGGGTTGTCACAGGCAAAACTGCTGGAACTCAGGGCAGCATTGCAAATGCCA
CGCCGCTCTCAGGGCCCCTTGCCTGCCGCTGGAATTAAACCCACCCAGATCTTGGAAACTCTGCCCTGGA
CCCTTCTCAATAAGTCCATGAGAAATCAAACTCTTTCCTTTATGCGACACTGGATTTTCCACAAAGTAAA
ATCAAGATGAGTAAAGATGTGGTTTCTAGATAGTGCCTGAAAAAGCAGAGACCATGGTGTCAGGCGTCAC
CACTTGGGCCTATAAAAGCTGCCACAAGACGCCAAGGCCACAAGCCACCCAGCCTATGCATCCGCTCCTC
AATCCTCTCCTGTTGGCACTGGGCCTCATGGCGCTTTTGTTGACCACGGTCATTGCTCTCACTTGCCTTG
GCGGCTTTGCCTCCCCAGGCCCTGTGCCTCCCTCTACAGCCCTCAGGGAGCTCATTGAGGAGCTGGTCAA
CATCACCCAGAACCAGAAGGTGAGTGTCGGCTAGCCAGGGTCCTAGCTATGAGGGCTCCAGGGTGGGTGA
TTCCCAAGATGAGGTCATGAGCAGGCTGGGCCTGGTCCTAAGATGCCTGTAGGTCAGGAAAAATCTCCAT
GGACCAAGGCCCGGCCCAGCCATGAGGGAGAGAGGAGCTGGGCTGGGGGGCTCAGCACTGTGGATGGACC
TATGGAGGTGTCTGGCAGACTCCCCAGGGACTACCTGCTCTCCTGGCCTGGCCTTGTCTGCCACTGCCAG
CTCCTACTCAGCCATTCCTGAACAGAGGACAGCAGAGAAGGGCCAGCACCCTCCCAGAACCATGTGGCAT
TTGCCAACTGGATTTTGACCATAACAATGCAGCCATTCTCCCCAGCACCATCATAGGCCCGCCCTTACAG
GAGGATTCCTTAGTAGAGTCCGCTCCTTGCCCCACTAGTAACAGCTCACATGTCTGAGCACTGCTTACAC
CAGGCCTGGTGCACGTGCTTTATGTGTCATTTCATCACTGCCAGCCACCTCAAGAGGCAGGTACGATGAA
CCCATTCTGCTAAGGTTCAGTGAGGTTAAGTGACAGAGGCTGGATTCAAGCCAGGCCTGGCCAACACCAG
AGTGTCCATGCTCCTAACTGCAGTGTTCCCTCACCATCAGAAGGCAGGGCATTTAATACACCAGATCCCC
ACCGCCTCCCATCTGATTTGTCTTGGTCAACAGTGGCCCAGGCCACTCCTACTTCACTCGTCCCCACCCT
GGCCCTTCCCGCAGGCCCCTGTCCTCCTGCCCTGACTATGGCAAGCCTTGCATGCAGCTTGTCCCTTACT
AGTGGTGTCAATTTTTTTCTCTCAGCTCCAAGACCCTAAACAGTGGGACCTCACCCCTATGCCTGCTGTT
CAAAGCAGAAAACGAAGCTCAGGAATGCTGAGGGGCTGCCAGGCCTGCCTCTGTGCCACACCAGGGATGC
TTGTGGGGCCTGTGCTGGGGCAGACCTGGCCTGGGCTGCCAGGGCAGGCCCACAACCCCTGCCAGCACTC
TGCTCACTGTCACTTTGCTCCCACAGGCTCCGCTCTGCAATGGCAGCATGGTATGGAGCATCAACCTGAC
AGCTGGCATGGTAAGGACCTTTGGGTGCAGGGAGGATGGGGCAGAGGCTCCAGGCCTTGGGCTTATCTTC
TCTGAGCCTCCCTTCCATGGCTGGGGTTCCAAGCAAGCTTCAAGTGCTCTCCTCCCTCCCGCCATAATCT
GGCCCCTTCCCGCCCACCACCCAGACTCACCTGCGCCAGGCATCTCAGCCCCATCTTCCTGCAGACTCAC
AAAAGGCAGCTGCCCAAGCAGGGCCTGACCCCTCGGTGTCCCCTCCCCACAGTACTGTGCAGCCCTGGAA
TCCCTGATCAACGTGTCAGGCTGCAGTGCCATCGAGAAGACCCAGAGGATGCTGAGCGGATTCTGCCCGC
ACAAGGTCTCAGCTGGGGTAAGGCATCCCCCACCCTCTCACACCCACCCTGCACCCCCTCCTGCCAACCC
TGGGCTCGCTGAAGGGAAGCTGGCTGAATATCCATGGTGTGTGTCCACCCAGGGGTGGGGCCATTGTGGC
AGCAGGGACGTGGCCTTCGGGATTTACAGGATCTGGGCTCAAGGGCTCCTAACTCCTACCTGGGCCTCAA
TTTCCACATCTGTACAGTAGAGGTACTAACAGTACCCACCTCATGGGGACTTCCGTGAGGACTGAATGAG
ACAGTCCCTGGAAAGCCCCTGGTTTGTGCGAGTCGTCCCGGCCTCTGGCGTTCTACTCATGTGCTGACCT
CTTTGTCCTGCAGCAGTTTTCCAGCTTGCATGTCCGAGACACCAAAATCGAGGTGGCCCAGTTTGTAAAG
GACCTGCTCTTACATTTAAAGAAACTTTTTCGCGAGGGACAGTTCAACTGAAACTTCGAAAGCATCATTA
TTTGCAGAGACAGGACCTGACTATTGAAGTTGCAGATTCATTTTTCTTTCTGATGTCAAAAATGTCTTGG
GTAGGCGGGAAGGAGGGTTAGGGAGGGGTAAAATTCCTTAGCTTAGACCTCAGCCTGTGCTGCCCGTCTT
CAGCCTAGCCGACCTCAGCCTTCCCCTTGCCCAGGGCTCAGCCTGGTGGGCCTCCTCTGTCCAGGGCCCT
GAGCTCGGTGGACCCAGGGATGACATGTCCCTACACCCCTCCCCTGCCCTAGAGCACACTGTAGCATTAC
AGTGGGTGCCCCCCTTGCCAGACATGTGGTGGGACAGGGACCCACTTCACACACAGGCAACTGAGGCAGA
CAGCAGCTCAGGCACACTTCTTCTTGGTCTTATTTATTATTGTGTGTTATTTAAATGAGTGTGTTTGTCA
CCGTTGGGGATTGGGGAAGACTGTGGCTGCTAGCACTTGGAGCCAAGGGTTCAGAGACTCAGGGCCCCAG
CACTAAAGCAGTGGACACCAGGAGTCCCTGGTAATAAGTACTGTGTACAGAATTCTGCTACCTCACTGGG
GTCCTGGGGCCTCGGAGCCTCATCCGAGGCAGGGTCAGGAGAGGGGCAGAACAGCCGCTCCTGTCTGCCA
GCCAGCAGCCAGCTCTCAGCCAACGAGTAATTTATTGTTTTTCCTTGTATTTAAATATTAAATATGTTAG
CAAAGAGTTAATATATAGAAGGGTACCTTGAACACTGGGGGAGGGGACATTGAACAAGTTGTTTCATTGA
CTATCAAACTGAAGCCAGAAATAAAGTTGGTGACAGATA
|
| Protein Name |
IL13_HUMAN |
| Length |
146 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-FEB-1994 |
| Definition |
RecName: Full=Interleukin-13; Short=IL-13; Flags: Precursor |
| Primary Accession |
P35225 |
| Accession Version |
P35225.2 |
| Other SeqIDs |
sp|P35225.2|IL13_HUMAN,gi|239938644 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Nov 27, 2009 this sequence version replaced gi:74720385, gi:74753701, P35225.1.; [FUNCTION] Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864). {ECO:0000250|UniProtKB:P20109, ECO:0000250|UniProtKB:P42203, ECO:0000269|PubMed:21622864, ECO:0000269|PubMed:7903680, ECO:0000269|PubMed:8096327, ECO:0000269|PubMed:8097324, ECO:0000269|PubMed:8639787, ECO:0000269|PubMed:8759755, ECO:0000269|PubMed:9013879}.; [SUBUNIT] Interacts with IL13RA2. {ECO:0000269|PubMed:20223216}.; [INTERACTION] P35225; P78552: IL13RA1; NbExp=6; IntAct=EBI-1647828, EBI-1391535; P35225; Q14627: IL13RA2; NbExp=9; IntAct=EBI-1647828, EBI-4320063.; [SUBCELLULAR LOCATION] Secreted.; [DISEASE] Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the IL-4/IL-13 family. {ECO:0000305}.; [CAUTION] It is uncertain whether Met-1 or Met-15 is the initiator. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=AAA36107.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA83738.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAB01681.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC03535.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAK53823.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-13 entry; URL='https://en.wikipedia.org/wiki/Interleukin_13'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il13/'. |
| Source Db |
UniProtKB: locus IL13_HUMAN, accession P35225;; class: standard.; extra accessions:O43644,Q4VB52,Q9UDC7; created: Feb 1, 1994.; sequence updated: Jun 16, 2009.; annotation updated: Oct 12, 2022.; xrefs: X69079.1, CAA48823.1, CAA48824.1, L06801.1, AAA36107.1, U10307.1, AAA83738.1, U31120.1, AAB01681.1, AF377331.2, AAK53823.1, AC004039.1, BC096139.1, AAH96139.1, AF043334.1, AAC03535.1, A47481, NP_002179.2, 1GA3_A, 1IJZ_A, 1IK0_A, 3BPO_A, 3G6D_A, 3L5W_I, 3L5W_J, 3L5X_A, 3LB6_A, 3LB6_B, 4I77_Z, 4PS4_A, 5E4E_A, 5L6Y_C; xrefs (non-sequence databases): CCDS:CCDS4157.1, PDBsum:1GA3, PDBsum:1IJZ, PDBsum:1IK0, PDBsum:3BPO, PDBsum:3G6D, PDBsum:3L5W, PDBsum:3L5X, PDBsum:3LB6, PDBsum:4I77, PDBsum:4PS4, PDBsum:5E4E, PDBsum:5L6Y, AlphaFoldDB:P35225, BMRB:P35225, SMR:P35225, BioGRID:109810, DIP:DIP-3224N, IntAct:P35225, STRING:9606.ENSP00000304915, ChEMBL:CHEMBL3580486, DrugBank:DB05305, DrugBank:DB11914, DrugBank:DB12169, GlyGen:P35225, BioMuta:IL13, DMDM:239938644, MassIVE:P35225, PaxDb:P35225, PeptideAtlas:P35225, PRIDE:P35225, ABCD:P35225, Antibodypedia:14499, DNASU:3596, Ensembl:ENST00000304506.7, Ensembl:ENSP00000304915.3, Ensembl:ENSG00000169194.10, GeneID:3596, KEGG:hsa:3596, UCSC:uc003kxj.2, CTD:3596, DisGeNET:3596, GeneCards:IL13, HGNC:5973, HPA:ENSG00000169194, MalaCards:IL13, MIM:147683, MIM:607154, neXtProt:NX_P35225, PharmGKB:PA199, VEuPathDB:HostDB:ENSG00000169194, eggNOG:ENOG502SZKX, InParanoid:P35225, OrthoDB:1578920at2759, PhylomeDB:P35225, TreeFam:TF336383, PathwayCommons:P35225, Reactome:R-HSA-6785807, Reactome:R-HSA-9012546, SignaLink:P35225, SIGNOR:P35225, BioGRID-ORCS:3596, ChiTaRS:IL13, EvolutionaryTrace:P35225, GeneWiki:Interleukin_13, GenomeRNAi:3596, Pharos:P35225, PRO:PR:P35225, Proteomes:UP000005640, RNAct:P35225, Bgee:ENSG00000169194, ExpressionAtlas:P35225, Genevisible:P35225, GO:0005737, GO:0009897, GO:0005576, GO:0005615, GO:0005125, GO:0005144, GO:0071345, GO:0071260, GO:0006955, GO:0006954, GO:0042116, GO:0001774, GO:1903660, GO:2000352, GO:0050728, GO:1901247, GO:0033861, GO:1901215, GO:0071635, GO:0030890, GO:0120162, GO:0032723, GO:0010628, GO:0002639, GO:0032733, GO:1901251, GO:0043032, GO:0043306, GO:2000231, GO:0050714, GO:0051281, GO:0048661, GO:0042531, GO:0010155, GO:0045471, GO:0032496, GO:0035094, Gene3D:1.20.1250.10, InterPro:IPR009079, InterPro:IPR020470, InterPro:IPR001325, InterPro:IPR018096, Pfam:PF03487, PRINTS:PR01929, SMART:SM00190, SUPFAM:SSF47266, PROSITE:PS00838 |
| Sequence |
mhpllnplllalglmalllttvialtclggfaspgpvppstalrelieelvnitqnqkaplcngsmvwsinltagmycaaleslinvsgcsaiektqrmlsgfcphkvsagqfsslhvrdtkievaqfvkdlllhlkklfregrfn |
|
