|
|
| Record Information |
| Record ID |
215 |
| Pubmed ID |
29920186 |
| SNP |
|
| Gene ID |
3567 |
| Protein ID |
P05113 |
| Vaccine Adverse Events |
|
| Vaccine |
acellular pertussis vaccines |
| Gene Name |
IL5 |
| Official Symbol |
interleukin 5 [Homo sapiens (human)] |
| Aliases |
EDF, IL-5, TRF |
| Other Designations |
interleukin-5; B-cell differentiation factor I; T-cell replacing factor; colony-stimulating factor, eosinophil; eosinophil differentiation factor |
| Chromosome |
5 |
| Location |
5q31.1 |
| Annotation |
Chromosome 5 NC_000005.10 (132541445..132556815, complement) |
| MIM |
147850 |
| DNA Sequence |
>NC_000005.10:132541445-132556815 Homo sapiens chromosome 5, GRCh38.p14 Primary Assembly
AACAGTTGTCTATTTTTGTTTTATTAGAACACAACATAACATTAAATAAATACTAATTTACCAAATTCTT
AACCATTTCATAAATACTATTAAGTTAACAGACATTTTACAGAATGTTAAGTTAAATAAGAAAAAAGTAT
ATCAATTTTGCCTGGAGGAAAATACTTCAATGATTCTGATATCTGAAATATATTTTAAGAATTTTATGCT
TTCTGGCAAAGTGTCAGTATGCCTGAAATATTTACTTTCCCTCTGAAGTTAAATTATACTGAAAATTAAG
GCCTGACTCTTTCTTGGCCCTCATTCTCACTGCAGTAAAATGTCCTTCTCCTCCAAAATCTTTGGCTGCA
ACAAACCAGTTTAGTCTCAACTTTCTATTATCCACTCGGTGTTCATTACACCAAGAAACTCTTGCAGGTA
GTCTAGGAATTGGTTTACTCTCCGTCTTTCTTCTCCACACTTTTTCTGTGAAAAAAGAAAAATGACAATA
GGTATTACAGGAAACTGTCAATTCCATAGAAATAGGCACAGCCAGACAAATATAGCTTCCATTGAATGTG
TGTAACTTACTTTTTGGCCGTCAATGTATTTCTTTATTAAGGACAAGTTTTTGAATAGTCTTTCCACAGT
ACCCCCTTGCACAGTTTGACTCTCCAGTGTGCCTATTCCCTGAAAGATTTCTTCAGTGCACAGTTGGTGC
TAAATGAGGAAAATTTTTAAAATGCAAATAATCAAGACAAGGTATAAAAATTTGGTCCATTGTCCATTCT
GCAATGTATACATACTTCAAAACATCATATTGTACACAATAAATATATATACTTTTTAATTCATCAATTA
AAAAATAATTATTAAAACAATTTTGGTCCACAAAGTTAGGCTTTGTTTTGTGGTATTTACATGAGTTCCC
TTCTCCAAAGAGTTTTTTGTTTGTTTTCTAGGCAACAAACCACCACATATTAAGATAAAATTTTCAAAAA
GTAGATGAAGCTTATATGATTACTGAGGAGTTTTATAAAGGATATAACTTAATTATGTAACTGGAAAAAA
ATGTTTTGGAAGTGTAATGCATTATACATTAAACTCATATCAATGTGTTTCTACAGTTCTAGCTGGTAGT
TTTATTCTATTTAGACTAATAAAACTATATATTTTACATTTTAATATGACCAGGACATATTCAAATGCAT
ACAACACCATCATATAGTCATAATTATTTAAGTATGCAGAAATTATTAATATAGGGCATTTGTTATATAT
TTTAATGTCTACTGATCATGGTTCTAAAAATATAATTCTGAGTTGCTAATACTTTCAGAAACACGTTAGA
GTGAGAAAGAGTCAGAACTGCACGGAGACTAGCACGCACCTCTCACTCAGTGTGGAATCCTTCTGGAAAG
AATCCCTGACACGATGCTCTTTGGGAGGCAAACTAACAACATCACCAAAGAGCCTAATCCACTTGTTTAA
AGGATTCTACTTGATAAAAAGTCATTCCTCATATTTATAAGTACAGACATTCACAGCCACCCATATGAAA
ACAAAATATAGAAAATTAAATAGTTCCAATGATAACTAATGATTTACAGCTTAAAACAGGAAATTTACTT
ATTCATGCCATCATTTTACTGAATCATAATTTAACTTACATTTTTATGTACAGGAACAGGAATCCTCAGA
GTCTGGAGAGGAAAGGAAATACAATCATTTTTACAGCACACCAGCATTCATAACTTTTAACAGAATGTTT
GCTGGTGATGTAGTTATCACCCATGTACTAATGTGCTCAGAATCTTATTATTTATAACAGATCTCTATAT
ATAGTAAAGGAACCATCACAAATGATTACCTATGCACTTTACAGACTGTAGGAATCATAAAGAAAATTAC
CTCATTGGCTATCAGCAGAGTTCGATGAGTAGAAAGCAGTGCCAAGGTCTCTTTCACCAATGCACTTGTG
GGAATTTCTGTGGGGATGGCATACACGTAGGCAGCTCCAAGAGCTAGCAAACTCAAATGCAGAAGCATCC
TCATGGCTCTGAAACGTTCTGCGTTTGCCTTTGGCAAAGAAAGTGCATAGTACAAGACTGCGTCCCCAGT
CAATTTATTGTCTGTCTTTGAGGAAATGAATAATTTCTAACAATCAGATAGAGAATGCCTAATAATGGCA
TATCGTGAAACTAAATGTTTCCAATGCCTTATATCTTAAAAAATAAATTTACTTTTATCTTTTAATAATA
AAAATCCCTGTTTCCCCCCTTTAAAAACATTTTCTATTACGAAGAATCTTTGGGTTAATACATCATTGCC
CCACATTTGCATTTCTTAAAATCAGAAAATTAACTTCCTCTTAAAAGATGTGTGCAAAACAAAGTATAAG
GTAGACCACTAAACAGAATTTTATGCTAAAATACATAAATATTGGGAATGTTTTTTTCAGATCGGCTATG
TTCTACTATGACTGTGGCTAGATTAATCTGTCTTAAAAGAAATTGAAAATACTGGTGGGAAGACAGTGAT
TGAAATGGAAACTGCCAAGCCTTGGCAGGGTCGAGTTCTGTTCACTGGGGTCTTGATTAGGATCCTTTCT
GTTGCCAGTGACTAAAAACCTAACCTAAAGTTGTTGAAGATAAAGAGGGAAGGTATTGGCTCATAGAACC
AAACAGTCCAGGAATGGAGGCTCTTTTACATTTTGATGGCTTCAGTGACTCTTCCTTGACTCCATCCTTG
GGCACCTTTCCCATTGAGGTCTCAAGATGATGTCCAGACTCCTGGATCTATATGTATTCTGTTCATGAGC
AGCAGGAAAAAGCAAGCTGTGCTTTTCTGATTGTTTAATCAAAAGCTTTCAAATTCAGTCTCTTTCTGAC
AAGGGTCACATGTTCATCCTTGAACTGTGACCAGGGTGTAGTATATACTGATTGGCTCTCCCTGGAGCTA
GAGGTGACCCTAATCCTACCTCAACTGCATAGCTTAGAAATGTGGGGTCCCAGTAGTAAGGGGGACACAG
ATTCTAGGAAGGCAACCAATAAATATCTGTCACAGATACACAATACATGGATGTGTCCTCTCCTTTATGT
CCCATAAGGGTGGAGGTGTCCTTTCACACCTTGGGCGGGCCATGAAATTAGGGGAATCAGCCTTTGTTCC
TTAGGCTCAGACCTGTAATCCCAGAAAGGTACAAATGAGGCCCCCTCCTAGATCACACACTTCCTTTTTC
CCTGGCCTGAACACATATGATGGAGGTGTATGTGGCTCATTGTTTTTAATAGAGTGCTTCAGTGAGCATC
CCAGAGTGGCTCTATGTTGCAGCCTAGAAGCCTGACTTCAGGCCTGTCTTGAGCGTCAAGAACAGATGGT
ACCAAACACAAACTGTTGCCCAGAACAGTTTTCCAAAGCTAGGTGCAGTTGTGTAGGAGAAGTAGAGGCA
GCTGGGAGGTAGACACACCTTTCATACATACTCAATCCCAGCTCTGCACTGGAAAGATAAAGACAGTCTT
GGATTTCAGTGGCGGCCTTCTTGTACCACGTTTGGTTTTGTTTGTGCTGAAGTTTTGGACTCTTGGTTAG
ATGTGTCTGATTTGCGCACTTGAGAAATGTTTTCCTTGAGAAATGTTTCCTTGAGACTGCAGAAGTTTGG
CTCACTTCAGAAAATCTATCGGGAGTGAGATTTTCGGGAGTAGGAATCACAATAGGCTTGGTCAAAGTGC
TCTTAAAATGGTATTCTCAGAAAAGAAGCTGAGTTCTGGCAGGAGCTTTCTCTTCCCAGAGAATATGAGA
GCGTTCTCTCTGATTCCCCCTGACACCTTTATGTTACACTGAGGAAGTTAGGGCTTAGGTGAAAGTTTCA
GGGGAATTGCCAAATAACTTGTTATTTTAGTACCTTAAATACACAAAGTTCTGAGTGCTTAAATTCTATC
ATAGGAGGCTGGGCAAGGTGGCTCATGCTTGTAATCCCAGCACTTTGGGAGGCTGAAGCAGAAGGATTGC
TTGAGCCCAGGAGTTTGAGACCAGCCCAGGCAACATAGTGAGACTCCATCTCTAGAAAAAATAAAAAATT
GGGCTAAACACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGTAAGCCCAGGCAGTGGATCCCTTGAGC
CCAGGAGTTCAAGACCAGTGAGTGAAATGGGCAGGGTGTAATACATCAAAGCTGGTGGGGGTCACATGAA
ACTATAGCATGCATGATCTGTCTAAAGGTGGCAGGTGCTGCTCAGCTCCAGCTGATGGTTGCCAGGTGAC
ACACCTGGGCTCACATTACCCGATCATTCTGTTTTTCAAAGAAGCCTTTATAAAAATTAGCCAGGCGTGG
TGGTGTGTGCCTGTAATCCCAGTTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACTCAGGAGGCGGA
GGTTGCAGTGAGCTGAGGTTGCACCACTGCACTCCAGCCTGCGCAAGAGAGTGAGACTGTCTCAAAACAA
ACAAACAAACAAAAAAACAAAAAGCACAACAACAACAACAACAACAAAAAAGGAAGGCTGAAATCCTGCT
TATTATATATAATCTCTGGATTTTTCAAATGTTGGCAACTGTATAATGTACCATTTTGCAGCCTCTGTTT
TACAGCAAAACTGTGGGTTCTTATTGGAAGGCTAGTTATAAAAAATACTTCTTATTCAAAATTGTATTTC
TTTTAGAAATGTTTAATTGTGGCAAAATACACATAAAATTTACTATCTTAACCATTTTTTTAAGTGTACA
GCTCAGTAGCCTTAAGTACATTCATAATGTTGTGTGACAAATCTCCAGGACTCTTTTCATCTTGCAAAAC
TGAAACTCTGTACCCATTAAACAACAGCTCCCAACCCCCGCCCCCATTCTCCCAGCACCTTGCAACCACG
CTTCTACTTTCTGTCTTTATGAATTTGATGACTTTAGGTACCTGATATACAGTACTTGGCTTTTTGTGAC
TGGCTTATATCATTTAGCATAATGTCTATTCTCAAGATTCATCCATGTTGTAGCATGTGTCAATTTTCTT
CCTTTTTAAGGCTGAATAATATTTCATTGGATGTCTATACCATGTTTTGTTTATCCATGGTCTGTCGATG
GACACCAATGTTGCTTCCATCCTTTGGCTATTGTGAATAATGCTGCTATGAACATGGGTGTACAAAATTA
AATTTCTTATAAAGTTTTCGTGTCATTAACTTTTCCTCTATAAGTGTGATCTCCCCAACCTGACTGTAAA
CTGTCTCGGAGTTGGACCTGTAAAATAATGTATTTGAAAGAGCTTTATTGGCCAGGCATGGTGGCTCACA
CCTGTAATCTCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACGAGGTCAGGAGATCGAGACCATCCTGG
CTAACACAGTGAAACCCCATCTCCACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCCGGCACCTGT
AGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGTGGATGTTGCAGTGAGCT
GAGATCACGCCACTGCACGCCAGCCTGGGCAACAGAGCGAGACTCCATCTCAAAAAAAAGAAAGAGCTTT
ATTAATGCAAAACTCCAAATAAAAGTTAATGATTTTAATCTCCTGTGCCCAAGAATTCAAAATAATGTAT
GTAGCTACTACACCCTCAAGGAGATGGAACACAACCCCCTTTCATTAAGAGTGGGATATACAGAGTGACT
TTTTAAAAAAGAGAACTGTATGGAAAGGGGAGAATAAGAGGAATAACTTCACAGTGGAGAAACCTGATCA
AACACTACTTCAGCTAGGTGATCCCAGTCAATGGTGGCAGTGAAACATCATGTTAACAGCATGTACCTTT
GATTTGATGTGATAAGAAAGGAACTTTATCCCTGTCATCTTCCTCCCCAAAACCAGTAACCTCTGCCTAA
CCATGACACAAACACTACACATACCCAAATGGAAAGACAAAATGCCTGACCAGTACTCCTTAAAACTGTT
AAGGTCATCAAAAACAAGCACAGTCTGAGAAACTGACACAGCCAGAGAGGCCTCTAAGAGACGTGATGAC
TACATACAATGTGGTATCATGGATGACACTCAGGAACAGAATAAGGACAACGGGCACAACTAAGGGAATT
GGAAAAAGCCTGGAGTTTAGTAATGTACCAATATTAGTTCCTTAGTTGTGACAATTGTACCATAGTAATG
TTAACAATGGGAAACTGGGTGCAGGGCACACTGGAATGCTCTCTAACAGTCTTGAAACTTCTCTATAAAT
CTAAAACTACTTAAAATAAAAAGTGTATTAAAAATAATACTGCGGCGAGGCATGATGGGTCAGGTCTGTA
ACCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATTGGTTGAAGTCAGCAGTTCGAGACCAGCCTGGCCAA
TATGGTGAAACCCTGTTTCTACTAAAATACAAAAATTAGCTAGGCTTGGTGGCTGGCGCCTGTAATCCCA
GCTACTTGGGAGGCTGAGGCAGGAGAATTACTTGAACCCAGGAGGCAGAGGTTGCCGTGAGCTGAGATAG
CGCCACTGCACTCTAGCCTGGGTGACAGAGCGAGATTCCATTTCAAATAAATAAATAAATAAATAATAAT
ACTGCACATTGAAAAAGTTAATGATTGTTTTTACCATTATTATTTAAAAGGCTTTGCTCAGGAGGCTGAG
GCCAGAGGATCAATCGGGCCCAAGAGTTTAAGACTAGCCTGGGCAACATAGTGAGACCCTGTCTCAAAAA
AAAAAAAAAAGCAGAACTTTGAATTCCATGAGTGTAATGCAGTTGGCACCTTTTTATTTCACCAGTAGAC
TATGAGCTCCTTGAGAATAAGGTTTTTATTGAATCGATCTCTTCATCCTTGAGGACTAGCCTATTGTAGA
CAGTAAAATAAAGATTTGTTAAATAACTAACTGAATGAACAAGCAGGCACTTACAACAACTTTATCTTTT
GTTGTACTCGTTGAGTTAATGTGAATACAGCAGGTCCTTGAATAACTTTGCTTAGTTCCACGTTATTTCA
TTATACTGTTGATAAGAAAAACAATCGCTTCCCAGCCAAAGCCATTGTCTATGTGGAGTTTGCACAATCT
CTCACATCCCAAAGATGTGCACGCGAGGTGAATTGGCATGTCTACACAGTCCCAGTCTGTGAGTGTGTGT
GTGTGCGTCTGTGTGTGCGTCTGTGTGCTCTGCAATGGAATGACGCCCTATCCAGGATTGGTGCTCACCT
TGTACCTTGAGCTACCGGGATAAACTCCAGCCATCTTCAACCTTCAACTGGAATAGTTGGGTAAGTTATC
TTACTTGTTTTTATGAATCTTTCTTAAATGTACATATAGCTCATAATTGTTTCAATGTTTAATATTAGAA
GTGTTTGGTCTTTGTTTAGAAGTGTGATGATATTTTTGTGGCCAGAAATATGCCATAGGAATGTAAGCTT
TGTTCATATCAATTCACCTACGGTAAAATTGGTTTTGTTATACATCGTTTCCCTTAAAGTCTGTTTCCAA
GAACCTATTGATGACATTAAGTGAGGATTACTATACTGTGGAAACTCAAGAAGTCTTTTTCTTTTTTTTG
AGACAGAGTCTTGCTCTGTCACCCAGGCTAGAGGGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCGCC
TCCCAGGTTCAAGCGATTCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCACCTGCCACCACGC
CCGGCTAACTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATCTTGGCCAGGCTGGTCTCAAACTCCTG
ACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCCGGCCT
CAAGGAGTCTTTTACCTGCAGCTAGGAGCCTAAAGTAACAAACAACAGGAGTTCTTTGGCAGAACTCCTG
GGCAAAAGAGAGCAAAGCTTTAAAGTTCAGCTACAGAGACGGAGGCAATGTGAACTACCATTTAGATTTT
TTAAAATCCACGTTATTTTAGGGAAATAGAAAGAAATAAACAATTAGTACTTTGATTTTTAAATAATTAC
TGGTTGGTAATTTTATAATTTAAAAAAAGCACTTTGATTAATATTGAAAAGTTACATTGGTGGGTAACAT
CCATCCTTTTGCCCTAAAACTTTTATCTCTATTAGTGGGTAACACATTGGCAACATGTCTTTAAAACTGA
TAACTGTGGTTTTTACTGTGTAGTCCTTAAGGTCAAATGACTTTTCCATGAACTGATTCTAATCAACTGA
GCATGATGCCTCGCAATTTTCATGATGACTAAATGTAAATTGATAACATCTCTTTTTCTTCTTGACTCTA
TTCGAAATTCTATCCTTTCAATCTCCCTTTAATATGATTTTTTAATTGAATAAATAACATTATAGGAAAA
TAAACACAGAATTTCTTGGTATAGCAACTATCAGTTTTTTGAAATCATCTTCTAAACCTTACCAACACAT
AGACAGTTTTACAGTTTTAATCAGTGAATATATGCAGTTTGTATTTATCTTTTTTATGAGTATTTCTTTT
TCACATATCTATACAATTTCCTACTTATTATTTTAGTGATAACCTGCTATTAGATGAAACTGATGTACCA
TAGTTTCCATCACCATTTCCCAACTTTTAGGCACTGGGGTTGTTTCTAGCCTTCCACAATTTTAAACAAT
GCTACTATAAACACCTGTGTAAAATTTTAAAAATTTTCCTTATGCTAATGAACTTGTATAATCATGTTTA
TAGCTTTGTTACATTTTACCAGATTACCCTCTGAAAATATCCAATGCAGAAAAAAGAAATCTTTTTTTTT
TTTTTTTTGAGACAGAGTCTCACTCTGTCGCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAA
GCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCAGAGAAGCTGGGACTAAAGGCACGCGC
CATCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCAACAAGTTGGCCAGGATGGTCTTG
ATCTGTTGACGTCGTGATCTGCCCATCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCAATGCG
CCTGGCCAGAAAAAATAACTCTTATATTTTCACAGGGTTTTACAATTTATAAAGCATTTTCACAAAAATA
GCTTTGTTTAATCTTGATATTAGCACCAGGAGATATATTTCTTTCTCTGAAGGTCCATTAGCACCAGGCT
TTAAAGGTTTTGCTAATGGAGAGCGAATGAACCCAGAAGGAAGAAGTGACGCAGAAGCAGTGGGAATCAA
AGAGTTTGATAAATATGCTGGTAAACCTAAATGAATAATGCTGGTTTAAAAATAACTGATTTCATTTGTT
TTGTTTCTTATTTGAAGACAATGAGGAACAAAAATGCTAAATAGTGATAATGTGGAAGGTGGGGGGTGAT
CTTCTGGCACATTTTACAGTCCTTGTATTGTTCAGAAGGATCCTAATGATATTAACTCTGGACTTCAAAA
TAGTAATGTGAAAAATTTAAGAGTGCCCAGTAAAAGAATAGAAATAGAATGTGTATTTTCCAAATCAGTA
GAGTAAAACAAGGAATAAAGAAAGCTTGGATATTCTACAAAGCAGGAAAGGAGACAAAGAAACAAAGAAA
AAGCACAGGAATAAGACATATGCCTAAATTTACCAGCAATCACAGTAATTGAAAACAGATGAAAGTCATT
TATTAAAAGGCAAATACTATAAAATTGCATTAGAAATCATCTATCAGCTATTTTCAAGAGATACACAATG
CAAAACAACATAGGAAGTTTGGATGCAAAGATACATAGCAGGTCCTAGAATAACTTTGTTATAACATTCA
CGAGAAAACAATAATTAATTCTTGGCCAGGCTGTGTGGAGTTTGCACATTTCCTAATGTCTGTGTGGGGT
TTCTCTGGGTACTCCAGTTTCCTCTCACATCCCAAATATGTGCATGTGAGGTGAATTGGCATGTCTACAT
AGTCCCAGTCTGCGTGTGTGTGTGTGTGCGTGCATGCATGTGTGTGTGTTCTGTGATGGAATGGCATCCT
GTTCAGGGTTGGTGCCCACCTCGCACCCTGAGCTGATGGGAAAAGCTCCAGCCACCTGCAAACTTGAACT
GGAATAGTTGGGCAAATACTTATTTTACTTGCTTTTATGAATCTTTCTTAAATGTATCTATTGCTCACAT
TTGTTTCAATGTTTAATATTGAATAGAAGTGTTTTCATCTTTATTTATAAGTTTGATGATATTTTTATGA
CCAAAAATATGTTCTACGAACTTGTCTCTTGTTTATATCAACTAGGCTATGATAAAATTGGTTTCACTTC
CCTTAAATTGCAATTTCTAAGAACGAATCCATACTAGTCAAAAGAAAGCTCATGTACCAATATTAATATC
AGAAAAAAGGGAGAATTATGTTAGAAAGTATTGTAAGAATAAAGAGGTTCTCAGGCTGGGCGCAGCGGCT
CAAGCCTGTAATCCCAGCACTTTGGGAGGGTGGTTCATGAGGTCAAGAGATCGAGACCATCCTGGCCAAC
ATAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCTTGGTGGTGCACGCCTGTAGTCCCA
GCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTG
CGCCACTGCACTCCAGCCTGGCAACAGAGCGAGACTCTGTCTCAAAAACAAAAACAACAACAACAACAAC
AAAAAACAAAGAATAAAGAAGTTCTCTATTAGGTATAAAACAGTATCTCATAGTAGTTTTATTTTTTATT
TCATTAATTTTAGCACCAGTGAAACTAAATATTTTTTGGAAGTAGTAGTTTACTAAGAAGTGGAGACTTC
ACTGATTTGCCTTTTTATTTTAGGGATTAATCATTTTGATTACAAATCTTTTCCACCCCAATCCTAGAGC
TTTTATCTTAGTTTTATAGTTTCCATTGTTACAAAGTTGAAATTTTTTTGTAATGGAACCTGGTTACCTT
GGCATGTCCATTTTTTTCCTTCAACTCACTATTTTTTTTCTGAAGTATTTTAAATTACAGACAACATGAC
ACACTATCACTAATACTTCCATATGCATCTCAAAAAAGATCATTTTCTTACATAGCAAAATATTATCACA
CCAAATACAATGAAATTAACAAGAATTATTATTATTTTTGAGATAGAGTCCTGCTCTGTCACCCAGGCTG
GAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCTACCTCCCGGGTTCAGCGATTTTCCTGCCTCAGC
CTCCTGAGTAGCTAGGACTACAGGTGCATGCCACCAGGCCCGGCTAATTTTTTGCATTTTTAGTAGAGAC
GGGGTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGGCCTCATGATCCGCCTGCCTCAGAGAATTT
TTTTATTATCTAATTTCCAGTCTACATTGAAATTTCCCTACTTATCTCCCAAATTTCCTTCACACATCTA
TGGCAAAACCAGTTTCCAAACTAGGACCATGCATTCCATTGGGGTGGTATGTATCTCAAATCTCTTAATT
TGCAACAAAATGTTTTTTAATAAGTCTTTTAAAATCTACAATAGTCTTTGCTTTAATGATAATGATCTCC
TGAGAGCCTGTGCCAGTGTCTTGTAACAGTTTCTAGCTTCTGGATTTGCCTTTTCCAACCCTGTGTTGCT
GTTAGCTTAATCCTTGTAATTCCTGTGAACTGAAAGTTACATCTAAAGGTATGATTAGATTCAAGTTCAA
CTTTTTTCCGTTTTTAAGAAAGCAAAACTGCATAAGAGATAATGTTGGGTACTTCATGCTAAGACCAGAG
ACAAGCAATATCTTATCTCAGTGATTGCTAATTTCTTATGCTACTTTGGGTCATAAAATTCCCCTTTAAA
AGTAGAGGTAATTACATTTCTTGCTTCTTCTTTTATTGCTTCCCGAAATATCTTTCTGAAATTTTATCCA
CCAGAACTTACAGTGGTAAGTAAAGTAAAGTGTAGATTTGCTTTTTTCTTCCTACTGATATCCAAGTCTC
CACAGTATTCATTTAAATGGTCTTGGTGGTGGCCGGGCACGCTGGCTCACGCCTGTAATCCCAGCACTTT
GGGAGCCCGAGGCGGGCGGATCGCGAGGTCAGGGGATAGAGACCATCCTGGCTAACACGGTGAAACCCCG
TCTCTACTAAAAATACAAAAATTAGCCGGGCGCGGTGGCGGGCGCCTGTAGTCCCAGCTACAGTCCTCAG
AGGCTGAGGCAGTAGAATGGCGTGAACCCGGGAGGCGGAGCTTCCAGTGAGCTGAGATCGCGCCACTGCA
CTCCAACCTGGGCAACAGAGAGAGACTCCGTCTTAAAAAAAAAAAAAAAAAAAAAAAAAGGTCTTGGTGG
TTTACACAAATGTTTATATTTGCCAAAACACATGGAATTGTACCCTGGAAAAGGGTGAATTTTACTGTAT
GTTAATTATGCTTCAATAAATCTGACTTAAAAAATGGTCTTGGCCAGGCGCAGTGGCTCACACCTGTAAT
CCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTTAGGAGTTCGAGACCAGCTTGACCAACATG
GTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGTGTGGTGCCACGTGCCTGTAATCCCAGC
TACTCAGGAGGCTGAGGCAGAAGAATCACTTGAACGCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCGCA
CCATTGCACTCCAGTCTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAGTCTCCA
CTTGAATAGTCAATTATTCAAAGATACACAAATGGCCAATAAACACATGAAATGATGCTACTAATAATTA
TTGAAATGCAAATCAAAATTACAATGAGGTATCACTTCACACTCATCAGGATGGCTACCATAAAAAAACA
TAAAATAACAAGTGTTGGCAAGCATATGTAGAAATTGAAACCCTTATGCACTATTGGTGGGAATGTCAAA
TGGTACAACCACTGTGGAAAACAGTATGGCAGTTCCTCAAATAATTAAAAATTGAATTACTGTATGATCT
AATAATTCCACTTCTGGGTATATACCCAAAAGAATTGAAAGCAGGGTCCAGAAGTGACATTTGTACACCA
ATATATATAGCCACACTATTCACAATAGCTAAAACGTGAAAGTAACCCAAATGTCCATCAATAGATGGAT
AAGCAAAATGTGATGTGTATTGTAATGAATCTTATTCAACCTTAAAAACGACCTGAATTCTGATATATGC
TACAGTGGTCCCCAACCTTTTTGGCACCAGGGACCAGTCTCACGGAAGACAGTTTTTCCACAGACAGGAG
TGGGGTGATGGTTTTGGGATGAAACTGTTCGACCTCACATCATCAGGCATTAGATTCTCATAAGGAATGG
GCAAGCTAGATCCCTTGCATGGGGCAACCTACATCTTTCTCATGGGCAGTTCAAAATACGGTTTGTGCTC
CTATGAGAATCTAATGCCCCCACTGATCTGAGGCCCAGCTCGGGTGGTAATGTTCACTCACCTGCTGCTC
ACCTCCTACTGTGCCACCAGGTTCCTAACAGGCCAGGTATGCATACTGGTCAGTGACCCAGGGGTTGGGG
ACTGAGCTGCAACATGGATGAACCTTGAGGACATTATAAGTGAAATGAGCCAGTCACAAAAAGATAAATA
CTGTATGATTCCACTTATATGAGGTACTTAGTAAAAAATTATAGAGACAGTAAGTAGAATGTTGGTTGTC
AGGGTTTGGAGGATGTGGGGAGGAAAGGGTTATTGTTTAATGGGTAGTTTGTTTTGCAAAGTGAAAAGAT
TTGTAGAGGTTGAAAGGTGGTGACGGTTGTACGTGAGTATACTTAACACCACTGAAATGTACACTTGGTT
AAGATAGTAAATTCTTTTTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCGGTCTC
GGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCATACTCCTGCCTCAGCCTCCTGAGTAGCTGGGACC
ATCGGCGCCTGCCACCATGCCCGGCTAATTTTTTGTGTTTTCAGTAGAGACGGGGTTTCACCGTGTTAGC
CAGGATGGTCTTCATTTCCTGACCTCGTGATCCACCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGC
GTGAGCCACCGCGCCTGGCCAAGACAGTAAATTTTATGTGTATTTTACAATTTTTAAAATAAAAAAAGGT
CTTTCGTCTTTTCCCATTGTTTTATTACATTTGCTTTGCCAAGTAAGACATTCCTATATAATTTTAATGT
TTTGTTCCATTAGTTATTTTAACTATTTTGTAATAACTGACACTTTCCGGTTTTTTTTAACCTGGTACAG
CAAGAGACTATTTCTCACTGGTCTTCCCCACTTGCATCCTTTGGCACATACATTTATGTATTAGGTTCTG
TAAATTATTTGCTTGGGATTGTATGACTGGAGAAACATTTCCTACATTTTTCCAAGGCAGGCAGAGGCAA
ATTATACCACTACAGTAATTCCAAATTTGTGTTTCATTTAAATGTCCTCCACTATTGTTTCAGTAATTTT
TATGTATGTTTCTCTAGGCCCTTAAATGTGATATCCCTCCATTAAGTTTGTTTCCAAGAAAGCAATATTC
TCAGTTACTTCTGAGACAGGTAACTTCTCTTTCCCTTATTTTTAAAGATATCTATTGCTGGGAGCACTGA
TCGGAATGGATTACCTCTACATTCTTCATATTTGCAGACTGCTTTTAGTTTTAGTTCCCAGACTTTTGGT
CTTAAAGACGCCTTTACACTAAAAAATTACGGGGGACCTCAAAGAGCGTGTACGTGAGTTATAATTATCA
ACATTTACTCAATTAGAAATTAAAATTGGTATTTCTAAGCGCAAGAATACACATGCGCACATTCCATTAA
CCGCCACTGCAATGGCGTCATCACATGTTATGTGATCACTGGAAATTACTACACGAACGTTAGAGAGAGA
ATGAGAATGAAAAGGAAAATAGTTTTGACACGAACTGACCCCGCTTCCTGGGTCTCCAATCCACCCCACC
ACTACCCCCATTCCAGGAGTCCCAGGATCAAGCTTTGGGAAGCGCCATCCGTCACAGGTCTTGGTCTCCC
CTTCCAAAAGTCAGTGCCTCTCCAGGCTGCCCATCCCCAGC
|
| Protein Name |
IL5_HUMAN |
| Length |
134 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
13-AUG-1987 |
| Definition |
RecName: Full=Interleukin-5; Short=IL-5; AltName: Full=B-cell differentiation factor I; AltName: Full=Eosinophil differentiation factor; AltName: Full=T-cell replacing factor; Short=TRF; Flags: Precursor |
| Primary Accession |
P05113 |
| Accession Version |
P05113.1 |
| Other SeqIDs |
sp|P05113.1|IL5_HUMAN,gi|124341 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Apr 6, 2005 this sequence version replaced gi:88021.; [FUNCTION] Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658). Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138). {ECO:0000250|UniProtKB:P04401, ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:22528658, ECO:0000269|PubMed:2653458, ECO:0000269|PubMed:7613138, ECO:0000269|PubMed:9010276}.; [SUBUNIT] Homodimer; disulfide-linked (PubMed:8483502, PubMed:22528658). Interacts with IL5RA (PubMed:1495999, PubMed:22153509). Interacts with CSF2RB (PubMed:1495999). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:22153509, ECO:0000269|PubMed:22528658, ECO:0000269|PubMed:8483502}.; [INTERACTION] P05113; P32927: CSF2RB; NbExp=2; IntAct=EBI-2435811, EBI-1809771; P05113; Q01344: IL5RA; NbExp=2; IntAct=EBI-2435811, EBI-1759442; P05113; Q01344-2: IL5RA; NbExp=4; IntAct=EBI-2435811, EBI-15957545.; [SUBCELLULAR LOCATION] Secreted {ECO:0000269|PubMed:2653458}.; [SIMILARITY] Belongs to the IL-5 family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-5 entry; URL='https://en.wikipedia.org/wiki/Interleukin_5'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il5/'. |
| Source Db |
UniProtKB: locus IL5_HUMAN, accession P05113;; class: standard.; extra accessions:Q13840; created: Aug 13, 1987.; sequence updated: Aug 13, 1987.; annotation updated: Oct 12, 2022.; xrefs: X04688.1, CAA28390.1, J03478.1, AAA74469.1, J02971.1, AAA98620.1, X12705.1, CAA31210.1, X12706.1, CAA31211.1, AF353265.1, AAK19759.1, BC066282.1, AAH66282.1, A28477, NP_000870.1, XP_011541675.1, XP_011541676.1, 1HUL_A, 1HUL_B, 3QT2_C, 3QT2_D, 3QT2_E, 3QT2_F, 3VA2_A, 3VA2_B; xrefs (non-sequence databases): CCDS:CCDS4156.1, PDBsum:1HUL, PDBsum:3QT2, PDBsum:3VA2, AlphaFoldDB:P05113, SMR:P05113, BioGRID:109781, DIP:DIP-28N, IntAct:P05113, STRING:9606.ENSP00000231454, BindingDB:P05113, ChEMBL:CHEMBL1169600, DrugBank:DB06612, DrugBank:DB01411, DrugBank:DB06602, DrugCentral:P05113, GlyGen:P05113, iPTMnet:P05113, PhosphoSitePlus:P05113, BioMuta:IL5, DMDM:124341, PaxDb:P05113, PeptideAtlas:P05113, PRIDE:P05113, ABCD:P05113, Antibodypedia:4146, DNASU:3567, Ensembl:ENST00000231454.6, Ensembl:ENSP00000231454.1, Ensembl:ENSG00000113525.10, GeneID:3567, KEGG:hsa:3567, MANE-Select:ENST00000231454.6, UCSC:uc003kxe.1, CTD:3567, DisGeNET:3567, GeneCards:IL5, HGNC:6016, HPA:ENSG00000113525, MIM:147850, neXtProt:NX_P05113, OpenTargets:ENSG00000113525, PharmGKB:PA29833, VEuPathDB:HostDB:ENSG00000113525, eggNOG:ENOG502RWD8, GeneTree:ENSGT00390000016991, HOGENOM:CLU_156269_0_0_1, InParanoid:P05113, OMA:RWRVKKF, OrthoDB:1469027at2759, PhylomeDB:P05113, TreeFam:TF338422, PathwayCommons:P05113, Reactome:R-HSA-512988, Reactome:R-HSA-5673001, Reactome:R-HSA-912526, SignaLink:P05113, SIGNOR:P05113, BioGRID-ORCS:3567, ChiTaRS:IL5, EvolutionaryTrace:P05113, GeneWiki:Interleukin_5, GenomeRNAi:3567, Pharos:P05113, PRO:PR:P05113, Proteomes:UP000005640, RNAct:P05113, Bgee:ENSG00000113525, ExpressionAtlas:P05113, Genevisible:P05113, GO:0005576, GO:0005615, GO:0005125, GO:0008083, GO:0005137, GO:0019221, GO:0006955, GO:0006954, GO:0018108, GO:0030890, GO:0051091, GO:0045893, GO:0045645, GO:0002639, GO:0050731, GO:0071803, GO:0046427, Gene3D:1.20.1250.10, InterPro:IPR009079, InterPro:IPR000186, Pfam:PF02025, PRINTS:PR00432, SUPFAM:SSF47266 |
| Sequence |
mrmllhlsllalgaayvyaipteiptsalvketlallsthrtllianetlripvpvhknhqlcteeifqgigtlesqtvqggtverlfknlslikkyidgqkkkcgeerrrvnqfldylqeflgvmntewiies |
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