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|
| Record Information |
| Record ID |
213 |
| Pubmed ID |
33326254 |
| SNP |
rs3901533 |
| Gene ID |
64581 |
| Protein ID |
Q9BXN2 |
| Vaccine Adverse Events |
grade 3 toxicities, hospitalizations, neuropathy, neuropathic pain, ophthalmoplegia,capillary leak syndrome |
| Vaccine |
GD2/GD3 vaccine |
| Gene Name |
CLEC7A |
| Official Symbol |
C-type lectin domain containing 7A [Homo sapiens (human)] |
| Aliases |
BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2 |
| Other Designations |
C-type lectin domain family 7 member A; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin superfamily member 12; DC-associated C-type lectin 1; beta-glucan receptor; dectin-1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1 |
| Chromosome |
12 |
| Location |
12p13.2 |
| Annotation |
Chromosome 12 NC_000012.12 (10116777..10130304, complement) |
| MIM |
606264 |
| DNA Sequence |
>NC_000012.12:10116777-10130304 Homo sapiens chromosome 12, GRCh38.p14 Primary Assembly
TTTTTTGATAAGAGTTTTTTTTTATTGAAATGAAATCCACATAACATAAAATCATCCATTTTAAACTGCA
TAATTTAGTAAAATTGGTACAATTTCTTTTCACATATTAATCAACATTAGAGGACTGTAAATGCCTCCCT
AGTAATACAGAAATATCCATTGGAAATAAAAATAGCACCAGTGGGAAAGTATGAAAAAAATAAGACAAAT
CAGCACATGAGGAAATATAGTTTCATTCCAATAATACCATTTTACAGTAATTACTGAAAAAAATGGTAAA
AATTGTAAAACAGTACATCACAAAACTAATAAAACATATTCCAAAATGTTAATACTTGTTCCAATGAGGT
TGGTTACTTTTTTATATTCATCATCAGATTTTATGTATTTTTATGTATTTTTGTATTTAAAAAGCAGAAA
ACTTTCCTATGAGAGCAGTTTCCCTACAATTACATATTATACAAGATTCTAGGCTGGGTGCAGTGGCTCA
CGCCTGTAATCCCAGCACTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGAGTTCGGGACTACCC
TGACCGACATGGAGAAACCCTGTCTCTACTAAAAAAATACAAAATTAGCCGGGTGTGGTGGTGCCTGACT
GTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGGGGCGGAGGTTGCGGTGAG
CCGAGATCGTGCCGTTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAAAAAAAAAAAAAA
AAAAAGATTCTATTAGAGATATGGCAGATGTACTCTCTGAGCTATTTAATTGATAAAGAAAAAGTAGGAG
TTCCTGCTTTTTACTAAGATGATAATCATAATTATGATCATACTGATGAAAATAATAAAATTGCTCTGAC
TGTGGTGAAGATTTTTTCCCATTTCTTCATTTAGCTATTCAGAAATATATTTCACCCTCAGTTCATAACT
GATATACTGCTAGAAGTTGAGGGTCAAATCGTGGCAACACACCGTGCACTTCAATGGCATTGTTGAGCAT
GAAACAACTCTGATAGAGCCAGAAATTAAGATTCGCTTATGGCTTACCCAAGGTAAATGCCAAGTCAATG
GCAGAATGAAAATTCAAGCTTGGGGCCAGGTGTGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGC
CAAGGCGGGCAGATCACTTAAGCCCAGGAGTTAGAGACCAGCTTGGTCAACATGGCAAAACCCAGTCTCT
ACAAAAAACACCAAAAATTAGCCTGGCATGGTGGCATGCACCTGTAGTCCCAGCTACTTGAGGGGCTGAG
GCGAGAGATAGCTGCAGTGAGTCGAGATTGTGCCACTGCACTCCAGCCTGGGTAACAAAGTGAGACCCTA
TCTCAAAAAAATAAATAAATAAAAAATAAAAACTCAAGCTTGGCTGCCCTGATTCCATGTCTAGGGATCT
ACTAACTAGAAAAATAATACTAGCCTACCTGTAGGTCGACAAATACAGAAATCACAGCCTCTCCCTTCAA
TTTCTTGGTTAAGATTACAGTTGGCCAAGCTCTCTAAACATTTTCTGCATTTATCTTGACCTCAGCTGTT
ACTCTTTTCTGTTCTGTTTTCTGTCCTCCTTACTACCTCACATATTTCTCTCTCCTTCTCCACCCTTCCT
CTTACATTGAAAACTTCTTCTCACAAATACTATATGAGGGCACACTACACAGTTGGTCATAAATGACTGA
CACGTGAATCCATACACAATTTGGAGATGGGTTTTCTTGGGTAGCTGTGGTTCTGATCTGAAATCTGTTA
AAATAGAATACAGTGAGGTAATTAGAACAAATGTTAAGGAATACTGTCTACATGGCGCACAAATAAATTA
GTAAGGATATTGGTGAAAAGAGTTCTGAAGTGTTTCTATTATTGGAAAAGGAGGCTTAAATCTAAATTGT
TGTGAATCTCAAGTGGTTAAATGAATAGTCTCCATTATTAAGGCAGAAAAACGACTTAATTTTTTTTCAA
GAACTGCTACTAGCTGCATAAACTAAAAAAAAAGTTCCTGACAAAGAAGAAAAATCATTTAATATTCTAT
AAAAAGTTCTTTATATATCTTTCAGCCTATTACTTAAATGTTTCTTTATCAAATCAAGTAACAGTTTAAT
TAAATTATTACTGGATATACTTAATGAGTAGACCAAGCAGAAGCATTAATGCTAAAACAGATCTAGAACT
AAAAAGAGAATCAGAGATGCCCAGGCCATTTAAAGGCAGGGCAAACAACTCTGTATATTTTAATGTATCC
TGGAAGCAGAATTATATTACAATACAATGCTTGACAGTTATGGAAATCAACACTGCTAAATGCAGGCATG
GTCCTGTTCAGTTTGGTCTTCAATCTCCTTAAGTAGCAGTGTTAATGAGTCAAGCTCAAAGAGCATCACT
GACCGTCAGTGCAAAAGCTATGACTTGGCACTCTTTGTCCTGGTTATGTATCTCTCCCTCTTGACCCTGA
GGTTGGAAGATTGAGAAAACTTTGCTTTAGCGATGACTAAGGCTAAGATTAACTACTTAGATTCAGACCT
CAGGGAGAACTCTGACCAGCATTATTCCTTAAAAATTTTCCTTGACCTATAAGTGTTTTGGGGGCATAGA
CACAGCTAGATTAAATAAATGCCACCCGGAAAACAAAAAAGTAGTAACATATCAAAATGTTAACTTGGGC
CCACTTGTGATTATAGAAAGAGTCCTCTAGTCATACATTTAAAATAGCAAGAGAAAACTCAAGACAAACA
AGTACTATAAGAAAGTAGAAAATACATTTGGCTGATAATAAATTCACTGTACTTAGCCTAGTAGAAGTAA
AACAGTTAAGTGATTATGCTCAGCAGTTTGTACTGTTCACACTATTGGGTGAACAGACCTGGTGGTGAGA
ACAGAGGCAAATGAAAAAACACTTCAAATTAATTCTACAAAGATTTTAAGATAAAATGTTAACAACACTA
TAAAAAGCAATCTGACATAAGAGAAAACTAATCAACACAAAAGAAAAATAGTAAAAAAAAAAACAAACAG
AAACAGATACATATAGAAAATTGGAATTATCAGACACAAGCTAAAACAACTATGGTTAGTGTATTCTGAA
AGTTAGAAGACAATACTAAGAATGTTGGAAGAAAAAGTAGAAGTATACGTGTTGAAATAATAGATTTGAG
AAAGAACTAAACTAAAATTATAAAACTGAAAATGTCACCAAACAAAATAAAAGACTTAATAGAGGCTTTT
AATGGTAGATTAGCCACAGATGAGAAAAAATAGATGACCGGAAGATATGTGAAAGGTTATTACATAGATT
GGAGCAAAAAGCTAAAAAAGAATGAAAACACAGGAAAAAGCAAAAGAAACATATAGGATGGTGTCAATGG
GTCTGTAATGAATGTAACTGGGATTCCAGGAGAAGGGAAAAAAGATGGGGAAAAGCAAAATATGAAGCAA
GTATGGCTGAGAATTTTTCAGTGCTGAGTAAACACATTAGTTTTAAAACATATATTACCTTCAAACAGAT
GACCTCTCAAAAACAACAGTAAAAAATAGAAAACAGTGGAATAATATATTTGAGTGGCTGAGAGGAAAAA
CAACAAACCTCTAATTCTATACTTACTGGAAATATCAGTCTTAAGAAAAAATACCTGTAATGTACAGTTG
GAAAGGAAGAAAGAAATAAACAACTAAAATCATAAATATGTGGGCAAATTGAAATGAATACTAACTGCAT
AAATCTGTGCGCCACCTTGTCTGTCTAATTTTTATATCTTTTTTTTTTTTTTGTAGAGATGGGGTTTCAC
CATTTTGGCCAGGCTGGTATCGAACTCCAGAGATCAAGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTG
GGATTATAGGCGTGAGTCCCCGCGCCCGGCCCAAGGGCTAGTTTTTTCTTTTTTCTTTTTCTTTTTTTTT
TTTTTTAATACTGAGTCTGGCTCAGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAC
CTCCGTCTCCCGGGTTGAAGCAATTCTGGTGCCTCAACCTCTGAGTAGCTGGGATTACAGGCGTCCACCA
CCACACCCAGCTGGTGACGCATAGCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATCGCTTGA
ACCCAGGAGGCAGAGGTTGCAGTAGGCCAAGATTGCCCCACTGCACTCCAGCCTGGGCGATAAAATAAAA
ATAAATAAATAAAAATAAATACATTAATATAATAGCATATAAATTGAGGAGAGAGTCAACAGAGTAAAGG
AATGCTCTATGATTTTTATATTGGTCAGGAAGAACATAAAAATGTCAGTTAATGTTAGTCTTTGATGAGT
GAAGTATACATGTGTAATTCCTAGAACAACTACTAAAAGATTAGTAAAAGAGATGTAAAAGACATGAAAG
AGCACATTCCAAATGAACAGAAAAAAAAAACAGAATAAGAAAAAGTGTTAAATCGTCCAAAAAGGAGGAA
AGAAAGGGGAAAAAAAGTAACAATTCTAAATCTTTATGTGCCTGATAACACGGCTTCAACACATCGAATA
AAATGTTTACAGAACTGTAAGTAGAATCGCAGCGGAAGATTTCAACACAATTCTTTTCATATGGAAAGAG
GAAGAAGCACGTAAAAATCACAGAACTACAAGCACGTGGAGCATGTTCTCTGATCACAGTGGAACTAAGC
CTGAAACCTAAAACAAAGAGATAACCAGAAACACATATGTTTGTAAATTAAGAAATGCATTTCTAAATAA
CTCCTGGGTCAAAGAGCAGCTCACAGTGGAAATCAGAAAGTATTTTGAACTGAAAGACAATGAAAATACA
TTAAAATTATAGCCTTAAGTCTACATACTTGAGATAAAGGAAGGCTTAAATTCATGAGGCAAGCACCCAA
TACGAGAAGTTTGAGATGGAATAGCAAATTTAAAACAAATAAATTAGGTCAGGAGATCGAGACCATCCTG
GCTAACACGGTGAAACCCCGTCTCTACTAAATATACAAAAAATTAGCCGGGCATGGTGGTGAGCGCCTGT
AGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTGGCAGTGAGCC
GAGATCGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAATAAAACAAAATAAAA
TAAAAATAAATTAGATGGAAGGAAGTAATACAGATTAGAATAAAAGTTAATGAAAGAAATAATAAAAAGA
CAGAGTCAACAAAGTCAAAAGTTACTTTCTTTGAAAAACCAAATTGAACGGTACTCCTACTGAGACAGAT
GAAAAAACACACACAGGTGTGCACACACACACTAATAATAAGAACTTAAAAGAGACATATTTCATATTCT
GCAGATATTAAAAAGCAAATGAATGACAACAGCAGTGACAGAAACCACATAATAAGGAATAATGTATCAT
CAGGCAAATGTGAAATACGTTTAAAATATCTTTCTAAAATGCAAAATGTGAAAATGTGGTTGCTTTTTAA
CTTAATAATAAGTCTCACACATTAACTATGTACAAGACACTGTGCTAAATTATTTTACTTTTATACCCAT
CTCACAATTCTAAGAGGAAAGCACTCTTTCTTTTTTTCTTTTTTTTTTTTTTTTTTTTTGAGTTGGAGTC
TCACTGGAGTCTCACTCTGTCATCCAGGCTGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCTGT
CTCCCAGGTCCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTTCAGGCAATGCCACCACAC
CCGGCTAAATTTTTAGTGGAGGTGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAA
GTGATCCGCCCACCTGGGCCTCCCAAAGTGCTGGGATTACGGGTGTGAGCCACCACACCTGGCCAAGAGC
ACCTTTCTATTCTTGTTTATGGAAAATGGGACTCAGAGAGGAAAAGTGACTTATCCCCAGTGTCACACAA
TCAGTGAGTGGGGTAATCATTAACCCAAACTGAGGCCTGGCTTCAAAACCCATGCTCTTAACCGGGGAGT
TACACTGACTGACAGTGACTGCTCCTTGCCTGGACAACTTCAAACATGTCGATGCCTCCCTAGTAAGAAA
ACCAGAAGAATATCTGTGTTGATGCTACTAGATGGCCTCACTCTTTTTCACTCTAAGGTCCTCCTCATCT
TTCTCCTCTTGTCCTAGTTCACTCTTTCTCTTCTTCTATATCTTTCTCCCTCTCTTTCTCATATATGGTG
AGCAAATCAGGTTCTTAGCTGCTCGACAGAGGTTTTCATAGATGAGATGGAAACCTCTCTGAGAAAAAGG
ATGAAGCATTGTCTCTCCAAACACTTACAAGTTAGAAGAGAATGTTGATCCATCCTCCCAGAGCCATGGT
ACCTCAGTCTGGGGCCGAGAAAGGCCTATCCAAAATGAATTATCAGGTTGGGAAGACACTTGTTTTACTA
TAAATCCCTGTAATGAAACATATACAAATATATAATAAAGAGAGAGAGAGAGAGAGAAAGAAACTATTAT
CATGGACGCTGAGAAAAAGACAACTGATTGAATCACTTTGGTAAAGAATGCAAGGCCGGGCGCGGTGGCT
CACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTAGATCATGAGGTCAGGAGATCGAGACCATC
CTGGCTAACAAGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGCGGTGGCGGGCGCC
TGTGGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAAGCGGAGCTTGCAGTGA
GCCGAGATTGCGCCACTGCAGTCCGCAGTCCGGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAA
AAAAAGAATGCATGCCTAACCTGACATCAACCTAGAGAGAAGTGCCAATTTTTGAATGTCATTGAATGTC
TCAAAAGGCCTATCTTATTTATTTAAAGTAATTATCATTTAATTTTCCAAAAGAATAGATTTGTAATGTG
AGGACTGTACTGCCTCCATTCAACCTATCTGACAAAATCCCAGATGACAGTCCCCCTAGGCAGTTTTCAT
GGATGATTAGCCATTGTCTTCTCCTCCAATTGAAGAAATAAATTGACGCTACTTTCGTTAAGAAGTACTT
CTCAGAGTTAGGTAACAACTTAAAAATAATTTAGTCCAACTGTATATTTTATGAATATGTAATCTGAGGT
TCAGTGAAGATATCTGAATTGTTTACAAATCTATAACAATTTATTTTCAATTATAGGCTGGCCTAAAAGT
CAGATAGACTTGTAATCCAGTACTCTTTCTTTGCCATATATCTAGTTCCATTAACTTTAATATAAATTAT
TACTACTGGGTAAGACATTACAGAAACAAAAACAAAATAAGAATAGTGAAAGTAGGTGTAGAAGTTATAG
ACTGGTTTAGATTTATAACATAGAATTTTTCCTATTAACCCCTTATCTTACCTCATTGAAGCTCTACCCT
TCATTCATGATGTGTTATAAGTGCCACTTTTTCTGAAAACTTCTTAGGAACACGGGGATCTCTTTAAACT
CCTATAGAATTTATTGCTAATGCCAGATATTTAACTTTTAATAGCTGCTGAGTTGCTTTTTTTTTACTTA
AAAGATTATATGTGTCCTGTGATAGCAGGGTTATGTTTTAACCCTCTTTGCCTTTCCCAGTATCTTGCAA
AGAGTAAATAATTTCTAAACATATATTATCATTGTTGCCATTTTTCTTGATAATTATGATGACAAGGAGA
AGAATTTTCTACTTTACTTCCACCATATTTAAAAATTGAAATACAAACTCACAAAAATGGGTAGTGTCCT
GATTATTGTAGTCATGCATACATGGAGTATGTTTGAAAGGATTTGTTTTAAGGCGAAACACAGTTTTTTA
AATTAGTTAAAAATAAAAGCATATACTATGCACTTTATGTGCTTAAGGCATGCTATGATTATAATTATAG
AGATATTAAAAATGAATTTTGGCCAAGTATGGTGGCTTACACCTGTAATCCCAACACTGGGAGATCGAGG
TAGGCAGATCGCTTGTGCCCAGGATTTTGAGACCAGCCCAGATGATATGGAGAAACCTCGTCTCTATGAA
AAATACAAAAAAACATTAGACGAGTGTGGTGGTGCACCCTGTAGTCCTACCTACTCAGGAAGCTGAGGTG
GGAGGATCACTTGAGCCTGGGATGTCGCGGCTTCACTGCACTCTAGCTTGGGCAACAGAGTGAGACTCTG
CCTCAAAAAAAAAAAAAAAAAAAGACTTCATTTTAGGAAAAATTGTCATTACCTGGAATCTCCCTCTATC
TTCCTTCAGGATACACACCACAGATAATCATAACAGAAGTCTACACTTACCAATTCATTTGAGCTGTCTA
TCTTTAGGAGATTAGAGCCCAGTTGCCAGCATTGTCTTTTACTTCCATCCCAGGAATTTAGTGACATGCT
GAATAGATAACAGCTCTTCTCATATATAATCCAATTAGGAGGACAAGGGCTGGAAAGAACCCCTGGAAAT
AAAAGATTAGTACCATGAGGTTCATAGCATACCAATTCACTCTTTTAGTGTGAACACCATTCATCTTAAG
GACACTTATGAAATAACCAATTAGTTGCCATTTTTATATTTCATTGTCAATTCGAACTACAGGGATATGA
TTTTACAGATGAGAATACATTAAAATCTTCCTATTCATTTAAAATTTAAAAACAAACTAGCTATAAATAG
TATTTTAGGCAGCCAACCATCCTTTTTTTCTTCACTTGTCTTCTATTCCTTCTAATTCAGCTCAAAACTA
CCTTTCTCCTTAATAACTCCTTAAAATAAGTCCACTCACAATCAGTCATTGAGGTACACAGCAATTTCAT
ATTGCTACTTATTTTATGATGTAAGATCTACTTCATAATGTGACTTTCCAAGTGAGAAAAGTATAGGCCA
ATTATTCATATTATACACTATCTCTGTTATATATTATTAGCTACTTAATAAAAATAGTGAGAAGGTATGG
GTCCAGAGATGAAAAATTGAACTGAAAACATTAAGTCATAGTCAATTATGATGCAATTAGAAGTAAAAGT
CAAGTGTGTATAGAATTGTAATTAAGTAAATGAAATTGTATGATTAAACAAATTTGATGAGTTTTCAGGG
ACATGTGTATTAGGTCTACCTCTTTTGTATATTTTTAATATAGCTTCCTTATTCTTGGCAACATTTTCCC
TTCTTTCCTTTCTCCCTGTCATTCTTCCTTTCTAATGTCATATTTCCTATTCTAACTGTATCGCATTTAA
AATGTCAATTCTGTAAGGGGAGAGAACACTTTTCTTTTATTTGTATCAAATTATATGATCTCCTGTAGAT
CTAAGCACATAGCCAGTGATAAATCAGTTACTGATTTTAAAAATTAATAAAGTCCAATTTAGAACTGTCC
AGCCAACTGCATAGGGTACTTATAATTTCACCTTATTGTATATATGACAGGGATACATTACACTAAGGTA
ATACTAATATGTGTATTTGCCTTAAATTTACAATCATTGAATCTAAGTGTTTTTCTTTACACCCCTGCCC
CAGGCTTCAGCACCAAGAATTAACCCTCTTGAGTCAAGATTCCGTCCTTTAACTATGCCCTTGCCTGTGG
TTTTGACAGCTTTGGTAGGAGTCACACTGTCTTCTAAAGATGATTGTGTGGGTTGACTGTGGTTCTCTTT
ATTTCTTGATAGAAAGTAGCCATTCTCCAATGTGTTGCTTCCTGAATTGGATCTCCAAATAGCTTCACAT
ACCAACAATAATAATAGTGACAGAAAAAATGTCATTCTGCTGTGTTTGAAAATTAAAATCCCAAAACCCA
AATGTTATTGGAATAAAAGAATACATTATTGATTAATGATAAATAGATGATATATTGCTGTGGAGAGATA
AAGACGATTGATAGAATAGATGAAAAGAAATACATAACTTTTATAAAGGAGGTATAGTAAAAAAAAAAAA
AGAAAAGAAAAAAGAAGGTGGAGAAGAAGAAATAGAATGAGGGAGGCAGCAAGAGGCAAATGTCATAGAG
TCAATTGGACCCATGACAGATTTGAAATAGCAACATCTTTCACCTTTCTTCTGTTATTTAAAAATGAGAG
ATCCTTGAGAAACTGCCCAGTACCTATAACATAGAACGCACTCAATAAACATTTGACTAATTAAGGAATG
TCATGAAGACTCTCTGAAGGTGACTGACAACAGATTGCATGTGATATAAAATGTAAAAAAAATATTAATC
CATTACAAAATATCGACTTAAGACCAAGTGCCTCAGGAAATTTCTGGTGTATTCAAAGGTGTTTATATTA
AAGATCGGAAATAATTTCCTTAAATAATGTGAATCATAAAAATAGCTTAATGTCCATTTAGTGAATTTAT
TTCATTAGGAAGACAGCACCATATTGTACTTTCTTCTTCAGCTCCGCTTGTTTTCTTCATTAATTTATCC
TTTGAATTCCACAGCTTTGAAACCAGCTATGTAAGGGAGGTAGGAGAGCAATGTAGTTAAGAGTATGAGT
TTTTTAGACAGATCACCCAAATTTCTAATCATGGTCCCACCACTAACTAGCTTATAACCCTGGAAAGGTA
AAATAACCTCTCAGTCTCTCACACCCTTTATAAGTGAAATGGGCATTAACAGCACCAACCCAATACAGAT
AAAACCAGATTATATACAAATTAAAGTAGATTATGCATGTCAAGCCCTTAAAAGAGTGCCTGGCACATAA
TAATTGCTTACTAAATTGTCTGTTGTTAATCTCCTCCACCAAATACTCACCCATGGTACCCAGGACCACA
GCTATCACCAGTATTACCAAGCATAGGATTCCCAAAATTACAGCAATGAGGCGCCAAGGAGGAGATGCAG
CACACGATCCTGAGGAGCCAGAGGGGGCAGAAATGGAATAAAGAAAGAGAATGACGGATGGTGGGGCAGT
TTAATTCTACAGTTCATCAAAAATCTGGCCTTGCACGGTGGCTCACACCTGTAATCCCAGAAGGGAGACT
GAGGTAGGAGGATTGCTTGAGGCCAGAAGCTCAAGACCAGCCTGGGCAACACAGGGAGACCCTGTCCCTA
CCAAAAAAAAAAAAGAAAAACAAAGAAAGAAAAAAAATTTAATTAGCTGGGCATTGTGGTGAGCTCCCGT
AGTCCCAGCTACTCTGGAGGCTGTGGCAGGAGGATCACTTGAGCCTAGGAATTCCAGAGCAGCATAGGCA
AAAAAGTGATACCCTGTTAAAACACACACACACACACACACACACACACACACACACACACCACCAACAA
CAACAACAAAAAATACTGGCAAATTTTTAAGTGAATTATTAATCACTGCCTAGGTTACCTGGTCACCTAG
GATTTGCTGTGCTTCTCCACCAGTAAGGATACCTTCTTCTTCAATTGCTGGAATTGTAATTTCGGCACAT
TGGCTTGATAACTGTATGCTCCTAATTTCAGTTCCACATTGACATCTACAGGTCTTGACATTAGTAGGAT
CCCTGAAATCCCACTGATTCTTAGAGGAAATAGCTTAATGTTGGGGAGATAGCACTGATTACTAAGGGTA
ATTTTCCCTTTTCATATGTTTGTTGCATGACCCTGGGCAAATTACTCCCTTTGTTGTTTTTTATTCCTCT
TTGTGAAACTGGGGTAATAATATCTCAAAGGATTATTGCGGGAATTAAACGAGCTAACACATATAAAAGC
ACCTTGTTTAGAGACTGCTAGCACATGATAGGTGTGTTGTTGCAGGATACCGTTTGCCTACACATATGCA
TAAACATGCGCATGTCTCCCTACCTCTTGCCTCATCCACTTTTTCCACGCTTCCTCAATAGGTTGCCCAA
GAAAAGAATTACATCAGTGCTGAGAGGAAAATATTTGTGCAGTGTGAATAACCAGAAAGCAGAAGAAAGC
AAACTCTGGTGTCAAAACCGACAAATGATCTCTCTCTCTCAAAGATAATAGGGAACTAATTTTGTATGAA
CATTGCCATAACCAGAATGTATTTCTGCTTTCCACTGTGACTAAGCTGTCAGGACATTTCATAGAATTGT
CACATAGGAGAATCGTAGAGTAGGCTAAATCACCCATTCTATGAATACAGAGATCCTCCAATGCCCTTCT
TTCTATTTCATTTCATTTACACTTTGTTTAAGACTCATGTCCTGCTGGTGGGATGTTTTTATCTACCATA
TGTTCATATATTTTCCATCACTGGTATACCAATAATTGTTTTTTGTTTAAAAACAATTTAAATTAATCTC
TTACCACAAAAAAAAAATGTTGTTCATATATATACTTCTTTAAGTTTCCTGGCCTCCATTCGATAATCTA
GCCTTTCTATCAAACAAGCAACAAGTCACTCATACAGAAATCCTTTATCTTTGTGTATTATCCCACTTAT
TACCAATTCCTCACTGATGAAATGTCTATATCTATAGAAAAGAGAAATTCTATTTTCTGCCATCAGACAT
AATTAATTTAAACACTAATAATTGGTCACTGAATAATTTTCATGAAAAAAGGTTTAGGGTGCATTCAATT
TATCTTCAGTGACATCTGAAGCCTTTAAAAGTATATCCATAAAAATATACACATCACGAGGCTCTCAAAT
TTTCTCCCCTTATATCTTTTTGTTTTGTTTTTATTTTTATTTTTTTTCAGAGATGGAGTCTTGCTCTGCC
ACCCAGGCTGGAGTGCATTGGCATGATCTTGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCT
CCTGCCTCAGCCTCCCAAGTACCTGGAACTACAGGCGTGCACCACCATGCCCGGCTAATTTTTGTATTTT
TAGTAGAGACAGAGTTTCACCACGTTAGCCAAGCTGGCCTCGAACTCCTGACCTCAGTCAATCCACCCGC
CTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCTAGCCTCCCCTTATATCTTTTCAA
ACGGGAGAGCTAAAGGCACACATTAGAAAAAACATATATATACCTTTCTCTGAAACAACAGCTATCCTGG
TATTGCTTTGAGAGTCGAAGTGTAATTGAGTATATCCATCTTCATCCAAATTTTCTAAATCAGGATGATA
TTCCATTGTTCTTGAGAGCCCCTGAATAGATATAGCATTTGGGAGCTCTTTTCTTTCTGCTCCTGAGATG
ACTGTCTGTGGACAAAAGAGAATCTCTGAGTCAAATCATGTGGGCTAGGTACTTACCGGAGTTTAACAAA
TTAAGCTTAAGTAGTTCAACCAGATATTCAAGAGCAGGAAATGAAACTATGCTGTGGTAATTTTCCATTT
GTACCTTTAGATCCTGTT
|
| Protein Name |
CLC7A_HUMAN |
| Length |
247 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
12-DEC-2006 |
| Definition |
RecName: Full=C-type lectin domain family 7 member A; AltName: Full=Beta-glucan receptor; AltName: Full=C-type lectin superfamily member 12; AltName: Full=Dendritic cell-associated C-type lectin 1; Short=DC-associated C-type lectin 1; Short=Dectin-1; AltName: CD_antigen=CD369 |
| Primary Accession |
Q9BXN2 |
| Accession Version |
Q9BXN2.1 |
| Other SeqIDs |
sp|Q9BXN2.1|CLC7A_HUMAN,gi|74752433 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Jul 30, 2013 this sequence version replaced gi:74717077, gi:74731406, gi:74736555, gi:74716726, gi:74716966, gi:74717078, gi:74717079, gi:74717080, gi:74717081, gi:74752578.; [FUNCTION] Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). {ECO:0000250|UniProtKB:Q6QLQ4, ECO:0000269|PubMed:11567029, ECO:0000269|PubMed:12423684, ECO:0000269|PubMed:17230442}.; [SUBUNIT] Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens. {ECO:0000250|UniProtKB:Q6QLQ4}.; [SUBUNIT] [Isoform 5]: Interacts with RANBP9. {ECO:0000269|PubMed:16870151}.; [INTERACTION] Q9BXN2; Q9BZ11-2: ADAM33; NbExp=3; IntAct=EBI-3939278, EBI-10303054; Q9BXN2; Q12983: BNIP3; NbExp=3; IntAct=EBI-3939278, EBI-749464; Q9BXN2; O60238: BNIP3L; NbExp=6; IntAct=EBI-3939278, EBI-849893; Q9BXN2; Q9BU27: FAM3A; NbExp=3; IntAct=EBI-3939278, EBI-10298603; Q9BXN2; Q01638: IL1RL1; NbExp=3; IntAct=EBI-3939278, EBI-993762; Q9BXN2; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-3939278, EBI-10266796; Q9BXN2; Q86UP2: KTN1; NbExp=3; IntAct=EBI-3939278, EBI-359761; Q9BXN2; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-3939278, EBI-10317425; Q9BXN2; Q16625: OCLN; NbExp=3; IntAct=EBI-3939278, EBI-2903088; Q9BXN2; P53801: PTTG1IP; NbExp=3; IntAct=EBI-3939278, EBI-3906138; Q9BXN2; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-3939278, EBI-741850; Q9BXN2; Q8N205: SYNE4; NbExp=7; IntAct=EBI-3939278, EBI-7131783; Q9BXN2; Q9BSE2: TMEM79; NbExp=4; IntAct=EBI-3939278, EBI-8649725; Q9BXN2; Q9NRS4-3: TMPRSS4; NbExp=3; IntAct=EBI-3939278, EBI-10312990; Q9BXN2; Q9BRL5; NbExp=3; IntAct=EBI-3939278, EBI-10296986; Q9BXN2-6; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-11989440, EBI-10225815; Q9BXN2-6; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-11989440, EBI-11343438; Q9BXN2-6; P07307-3: ASGR2; NbExp=3; IntAct=EBI-11989440, EBI-12808270; Q9BXN2-6; Q12983: BNIP3; NbExp=3; IntAct=EBI-11989440, EBI-749464; Q9BXN2-6; O60238: BNIP3L; NbExp=3; IntAct=EBI-11989440, EBI-849893; Q9BXN2-6; P19397: CD53; NbExp=3; IntAct=EBI-11989440, EBI-6657396; Q9BXN2-6; P04233-2: CD74; NbExp=3; IntAct=EBI-11989440, EBI-12222807; Q9BXN2-6; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-11989440, EBI-11989440; Q9BXN2-6; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-11989440, EBI-12019274; Q9BXN2-6; Q07325: CXCL9; NbExp=3; IntAct=EBI-11989440, EBI-3911467; Q9BXN2-6; P12314: FCGR1A; NbExp=3; IntAct=EBI-11989440, EBI-2869867; Q9BXN2-6; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-11989440, EBI-12142257; Q9BXN2-6; P08034: GJB1; NbExp=3; IntAct=EBI-11989440, EBI-17565645; Q9BXN2-6; P38484: IFNGR2; NbExp=3; IntAct=EBI-11989440, EBI-3905457; Q9BXN2-6; P26715: KLRC1; NbExp=3; IntAct=EBI-11989440, EBI-9018187; Q9BXN2-6; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-11989440, EBI-3923617; Q9BXN2-6; O14524-2: NEMP1; NbExp=3; IntAct=EBI-11989440, EBI-10969203; Q9BXN2-6; Q8N912: NRAC; NbExp=3; IntAct=EBI-11989440, EBI-12051377; Q9BXN2-6; Q9Y328: NSG2; NbExp=3; IntAct=EBI-11989440, EBI-7101695; Q9BXN2-6; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-11989440, EBI-2804156; Q9BXN2-6; P35372-10: OPRM1; NbExp=3; IntAct=EBI-11989440, EBI-12807478; Q9BXN2-6; P53801: PTTG1IP; NbExp=3; IntAct=EBI-11989440, EBI-3906138; Q9BXN2-6; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-11989440, EBI-3920694; Q9BXN2-6; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-11989440, EBI-8652744; Q9BXN2-6; Q16585: SGCB; NbExp=3; IntAct=EBI-11989440, EBI-5663627; Q9BXN2-6; Q9BZL3: SMIM3; NbExp=4; IntAct=EBI-11989440, EBI-741850; Q9BXN2-6; O43278-2: SPINT1; NbExp=3; IntAct=EBI-11989440, EBI-12078338; Q9BXN2-6; Q96L08: SUSD3; NbExp=3; IntAct=EBI-11989440, EBI-18194029; Q9BXN2-6; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-11989440, EBI-19027521; Q9BXN2-6; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-11989440, EBI-12947623; Q9BXN2-6; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-11989440, EBI-8649725; Q9BXN2-6; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-11989440, EBI-12345267; Q9BXN2-6; O00526: UPK2; NbExp=3; IntAct=EBI-11989440, EBI-10179682; Q9BXN2-6; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-11989440, EBI-744988; Q9BXN2-6; O95159: ZFPL1; NbExp=3; IntAct=EBI-11989440, EBI-718439.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17230442}; Single-pass type II membrane protein {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17230442}.; [SUBCELLULAR LOCATION] [Isoform 5]: Cytoplasm {ECO:0000305}.; [SUBCELLULAR LOCATION] [Isoform 6]: Cytoplasm {ECO:0000305}.; [SUBCELLULAR LOCATION] [Isoform 7]: Cytoplasm {ECO:0000305}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=A; IsoId=Q9BXN2-1; Sequence=Displayed; Name=2; Synonyms=Beta, B; IsoId=Q9BXN2-2; Sequence=VSP_022051; Name=3; Synonyms=C; IsoId=Q9BXN2-3; Sequence=VSP_022053, VSP_022056; Name=4; Synonyms=G; IsoId=Q9BXN2-4; Sequence=VSP_022052, VSP_022057; Name=5; Synonyms=E; IsoId=Q9BXN2-5; Sequence=VSP_022048; Name=6; IsoId=Q9BXN2-6; Sequence=VSP_022051, VSP_022054, VSP_022055; Name=7; Synonyms=D; IsoId=Q9BXN2-7; Sequence=VSP_022051, VSP_022053, VSP_022056; Name=8; Synonyms=F; IsoId=Q9BXN2-8; Sequence=VSP_022049, VSP_022050; Name=9; IsoId=Q9BXN2-9; Sequence=VSP_043298, VSP_043299; Name=10; IsoId=Q9BXN2-10; Sequence=VSP_047589, VSP_047590.; [TISSUE SPECIFICITY] Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269|PubMed:11470510, ECO:0000269|PubMed:11491532, ECO:0000269|PubMed:11567029, ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:12423684}.; [INDUCTION] Up-regulated during differentiation from monocytes into dendritic cells. {ECO:0000269|PubMed:12423684}.; [PTM] Phosphorylated on tyrosine residues in response to beta-glucan binding. {ECO:0000250|UniProtKB:Q6QLQ4}.; [POLYMORPHISM] A stop polymorphism at position 238 may be associated with invasive aspergillosis following hematopoietic stem cell transplantation (PubMed:20807886). The risk is highest when the polymorphism is present in both donors and recipients [MIM:614079] (PubMed:20807886). {ECO:0000269|PubMed:20807886}.; [DISEASE] Candidiasis, familial, 4 (CANDF4) [MIM:613108]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269|PubMed:19864674}. Note=The disease may be caused by variants affecting the gene represented in this entry.; [MISCELLANEOUS] [Isoform 2]: Predominant isoform. {ECO:0000305}. |
| Source Db |
UniProtKB: locus CLC7A_HUMAN, accession Q9BXN2;; class: standard.; extra accessions:B2R861,B7Z494,B7Z5A9,B7Z5B9,Q6IPS7,Q96D32,Q96DR9,Q96LD3,Q96PA4,Q96PA5,Q96PA6,Q96PA7,Q96PA8,Q9H1K3; created: Dec 12, 2006.; sequence updated: Jun 1, 2001.; annotation updated: Oct 12, 2022.; xrefs: AY026769.2, AAK20114.2, AY026770.2, AAK20115.1, AY026771.1, AAK20116.1, AF313468.1, AAK37473.1, AF313469.1, AAK37474.1, AF400595.1, AAL11711.1, AF400596.1, AAL11712.1, AF400597.1, AAL11713.1, AF400598.1, AAL11714.1, AF400599.1, AAL11715.1, AF400600.1, AAL11716.1, AF400601.1, AAL11717.1, AF400602.1, AAL11718.1, AJ312372.1, CAC43846.1, AJ312373.1, CAC43847.1, AY009090.2, AAG33923.2, AY359002.1, AAQ89361.1, AK297028.1, BAH12480.1, AK298679.1, BAH12845.1, AK298724.1, BAH12855.1, AK313247.1, BAG36058.1, AC024224.33, CH471094.1, EAW96144.1, EAW96145.1, EAW96146.1, EAW96150.1, EAW96154.1, BC013385.1, AAH13385.1, BC071746.1, AAH71746.1, BC093829.1, AAH93829.1, BC093831.1, AAH93831.1, NP_072092.2, NP_922938.1, NP_922939.1, NP_922940.1, NP_922941.1, NP_922945.1, XP_006719198.1; xrefs (non-sequence databases): CCDS:CCDS41753.1, CCDS:CCDS41754.1, CCDS:CCDS53744.1, CCDS:CCDS8613.1, CCDS:CCDS8614.1, CCDS:CCDS8617.1, AlphaFoldDB:Q9BXN2, SMR:Q9BXN2, BioGRID:122206, DIP:DIP-61730N, IntAct:Q9BXN2, MINT:Q9BXN2, STRING:9606.ENSP00000302569, ChEMBL:CHEMBL2034810, GlyGen:Q9BXN2, iPTMnet:Q9BXN2, PhosphoSitePlus:Q9BXN2, BioMuta:CLEC7A, DMDM:74752433, jPOST:Q9BXN2, MassIVE:Q9BXN2, PaxDb:Q9BXN2, PeptideAtlas:Q9BXN2, PRIDE:Q9BXN2, ProteomicsDB:79462, ProteomicsDB:79463, ProteomicsDB:79464, ProteomicsDB:79465, ProteomicsDB:79466, ProteomicsDB:79467, ProteomicsDB:79468, ABCD:Q9BXN2, Antibodypedia:23238, DNASU:64581, Ensembl:ENST00000298523.9, Ensembl:ENSP00000298523.5, Ensembl:ENSG00000172243.18, Ensembl:ENST00000304084.13, Ensembl:ENSP00000302569.8, Ensembl:ENST00000310002.4, Ensembl:ENSP00000312089.4, Ensembl:ENST00000349926.9, Ensembl:ENSP00000344723.5, Ensembl:ENST00000353231.9, Ensembl:ENSP00000266456.6, Ensembl:ENST00000396484.6, Ensembl:ENSP00000379743.2, Ensembl:ENST00000465100.5, Ensembl:ENSP00000436923.1, Ensembl:ENST00000529761.5, Ensembl:ENSP00000432876.1, Ensembl:ENST00000531192.5, Ensembl:ENSP00000434392.1, Ensembl:ENST00000533022.5, Ensembl:ENSP00000431461.1, GeneID:64581, KEGG:hsa:64581, MANE-Select:ENST00000304084.13, UCSC:uc001qxe.5, CTD:64581, DisGeNET:64581, GeneCards:CLEC7A, HGNC:14558, HPA:ENSG00000172243, MalaCards:CLEC7A, MIM:606264, MIM:613108, MIM:614079, neXtProt:NX_Q9BXN2, OpenTargets:ENSG00000172243, Orphanet:1334, PharmGKB:PA26581, VEuPathDB:HostDB:ENSG00000172243, eggNOG:KOG4297, GeneTree:ENSGT00940000161161, HOGENOM:CLU_049894_8_0_1, InParanoid:Q9BXN2, OMA:PNWIIHE, PhylomeDB:Q9BXN2, TreeFam:TF336674, PathwayCommons:Q9BXN2, Reactome:R-HSA-5607764, SignaLink:Q9BXN2, BioGRID-ORCS:64581, GeneWiki:CLEC7A, GenomeRNAi:64581, Pharos:Q9BXN2, PRO:PR:Q9BXN2, Proteomes:UP000005640, RNAct:Q9BXN2, Bgee:ENSG00000172243, ExpressionAtlas:Q9BXN2, Genevisible:Q9BXN2, GO:0009986, GO:0005737, GO:0016021, GO:0005886, GO:0001872, GO:0030246, GO:0042802, GO:0046872, GO:0042287, GO:0038187, GO:0061760, GO:0009756, GO:0001775, GO:0008037, GO:0071226, GO:0042832, GO:0016046, GO:0032491, GO:0001879, GO:0006954, GO:0006910, GO:0050850, GO:1903431, GO:0030335, GO:0008284, GO:0043280, GO:1900017, GO:0002732, GO:0051091, GO:0010628, GO:0043123, GO:0032729, GO:0032731, GO:0032733, GO:0032735, GO:0032743, GO:0032747, GO:0032755, GO:0032757, GO:0051712, GO:0051251, GO:0071639, GO:0051092, GO:0045429, GO:0050766, GO:0031334, GO:0060267, GO:0032930, GO:2000318, GO:0032760, GO:0090303, GO:0070884, GO:0043122, GO:0001878, GO:0002223, GO:0042110, CDD:cd03593, Gene3D:3.10.100.10, InterPro:IPR001304, InterPro:IPR016186, InterPro:IPR042808, InterPro:IPR016187, InterPro:IPR033992, PANTHER:PTHR47218, Pfam:PF00059, SMART:SM00034, SUPFAM:SSF56436, PROSITE:PS50041 |
| Sequence |
meyhpdlenldedgytqlhfdsqsntriavvsekgscaasppwrliavilgilclvilviavvlgtmaiwrsnsgsntlengyflsrnkenhsqptqssledsvtptkavkttgvlsspcppnwiiyekscylfsmslnswdgskrqcwqlgsnllkidssnelgfivkqvssqpdnsfwiglsrpqtevpwlwedgstfssnlfqirttatqenpspncvwihvsviydqlcsvpsysicekkfsm |
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