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| Record Information |
| Record ID |
206 |
| Pubmed ID |
34177914 |
| SNP |
|
| Gene ID |
10578 |
| Protein ID |
P22749 |
| Vaccine Adverse Events |
transient injection site pain, myalgia,fatigue,decreased hemoglobin,injection site pain,hematuria, CPK |
| Vaccine |
replication-deficient Ad39 vaccine |
| Gene Name |
GNLY |
| Official Symbol |
granulysin [Homo sapiens (human)] |
| Aliases |
D2S69E, LAG-2, LAG2, NKG5, TLA519 |
| Other Designations |
granulysin; T-cell activation protein 519; T-lymphocyte activation gene 519; lymphocyte-activation gene 2; lymphokine LAG-2 |
| Chromosome |
2 |
| Location |
2p11.2 |
| Annotation |
Chromosome 2 NC_000002.12 (85694358..85698852) |
| MIM |
188855 |
| DNA Sequence |
>NC_000002.12:85694358-85698852 Homo sapiens chromosome 2, GRCh38.p14 Primary Assembly
AAGCTGCAGGCTCCCTGCCCATAAAACAGGGTGTGAAAGGCATCTCAGCGGCTGCCCCACCATGGCTACC
TGGGCCCTCCTGCTCCTTGCAGCCATGCTCCTGGGCAACCCAGGTAAGGCCTTCCCCTCGGGATCGATCC
TGATGGCCCACCCAGCCTCGCACTCTCAGGCTGGCTGAACCTGGAGCTTGGACTCTGTGGGCACCCAGGT
GCCCCTGCCTCCCCCCGGCCTTCTCCCCCGTCATGGAGGCCTGGCCTCCCCTCAGAGCCAGGCTTAGTCC
AGTGTGCTGCCCAGCCTGTCACTGGCCTGGCCAAGGAGGAGAGACAGGCCAGGGATTCTGGTCCTAACTC
TACTGGCCACACTGTGTGGCCTGAGACCCCCCTTTCCCTCCCAAGCCCCTGCCTCCGCATCTGCGTGGTG
AAGGCCATTGGCCCTCATCGGTGGATCTGCGTTTCCTCGGGCCTACACTGTCTAGGATTGTGCGGGGCTG
GTGAGAGAACAAGATCTCTTCTGTGTTCAAGGCAGACTTCCTGCCCCCTGCACCCTGCTCTCTCCCAGGC
CTTGAGGTCAGTGTGAGCCCCAAGGGCAAGAACACTTCTGGAAGGGAGAGTGGATTTGGCTGGGCCATCT
GGATGGAAGGTAAAAAAAGAAAATCCCTTGAAAGGAGATTGAGGGAAGTTTCTAGACAAACCGACCCCCA
AATCTGTGTTGCTGGGGGAACAGAGGAGAAGAGAGAGTCTCGCCCTCCTGGCTTTCTAGAAGGAACGTGA
GAACACGTGTTTGTGCTGAGAGTGGGTCAGAGCGGCTCCAGGGCAAAGCATGTGGACAGGTATCCTGGCC
CCCTGCAAGGCCCAGCTCCTGTCCTAGGCCCTGGTCACCTCCTGGACTCCCACCAGCCAGGAGAACGGGC
TTTCCCTCTCCTTCCGCCTGCGGAGGGGAAGCTGAAGTCTGGTCTTCCTCAGGTCTGGTCTTCTCTCGTC
TGAGCCCTGAGTACTACGACCTGGCAAGAGCCCACCTGCGTGATGAGGAGAAATCCTGCCCGTGCCTGGC
CCAGGAGGGCCCCCAGGTACGTGTTGGCTCTCTGCTCACCTGCCACAGTCCCTCTCCTTTCCCTCCTCCC
TGGTGGCTCCTGGGGTGAGGTCTGGAGCTCTCTAATGGTCAGGAGGTGGGAGTGGAGGCTGGGCTGTTTC
TGACGATGCTGGTTTTGTTGAATTCATGTCTGGCCAGGAGGGCTACAGGTATCTGGCAGACTCCTCCAGG
AGGATCCTCTGGGGTCTCACCCTCCAAGGAGCCTGGGGCTGCAGAACCCAAATAGGCAGACTCCCCTGGG
AGTTCCTCAATAGGAGAGGGGCAAGTGCAGGGCTGGGAAAGTACTGGGGGTGTGGGAGGCTGTTTCTGGG
GTGTCTCAGAGCCTCTAAGACAAGCAAAAGGGTGGGCAGGGGCCAGGCAGCCAGTTCAGGCCTTCAGTGT
ATCCACGCTCTGGGAAGAGATCACGGACATTCCTGCCGGCCTCAGAAACACAAAGGGCCCCTTTCCTGGG
CACTTTCACGCGCTCCCAGAGTGTCTGAGAGACCATCATAAGGGCTTTCTTTCCTGACAGGGTGACCTGT
TGACCAAAACACAGGAGCTGGGCCGTGACTACAGGACCTGTCTGACGATAGTCCAAAAACTGAAGAAGAT
GGTGGATAAGCCCACCCAGGTGAGGCCAAGGGGCTACAGAGCCTCCTGTCTGCTGCTCAATGGAGGGGCC
AGCCTGTGACCAGGTCGGGGATCGGGGAGCCCGGGGGCACCTTGCACAGTGATCCTGGGGGAGGGCTTCC
TAGAAGGGAATCTGTGAGTCCCCGTGTGTCTGTGGATGAATTTCAGAGAACTTGTGAAATTGTGACTCTC
TGGAACTGTGTAAGTCAGACGGCAGAGTATACATGGTTTTCATCATGTATCCTCAAAGAGGGCTTGTCCC
AGAGAAGTTAGGAATCTTCCCCTAAAGCCCTAACATTTGTGTCCAAGGCAGAGTTTGAGAAGCTAGTTCC
CCAAGAGGCCTGGGTCAGGACTGATAAATCCCAGATCTGCTACTTCCAAGCTGCATGGCCTTGGGCAAGT
CACTTCCACTTTCTGAGCCTCTGTTATCTTATCTTTGAAATGTGATGGATAATAGTCCCTATCTTGCAAG
TTGTCAAACCCTTTTTTTTTTTTTTTCCTTGAGATAGGATCTTACTCTGAGACCCAGGCTGGAGTGCACT
GGTGTGATCTTGGCTCACTGCAACCTCTGCCTCCCTGGCCCAAGCAATTCTCCTGTCTAAGCCTCCTGAG
TACCTGGGGCTCCAGGTGTGCGCCACCATGCCCAGCTAATTTTTGTACTTTTGTAGAAACAGGGTCTCAC
TGTGTTGCCCAGGCTGGTCTCCAACTTCTGAGCTGAAGCAATCCACCTGCCTTGGCCTCCCAAAGTGTGG
GATTACAGGCATGAGCCACTGCACCTGGCTGCTGAAGCTTTTTAAAAGAGCTGAGGGCTGGGATGTACTT
AGCTCCACGTCCAGCACTGAGTAAATGCTTAACGAATGACTGTGTTACTACCAAGAATTATTGTTTCACT
CTCCCTCCTTCCCTCTCCTCTGCTGCCCCAAACTACTCAGCATCCTGGCACTGCAGGCTCGCACTTAGCC
CTGGATACCCAGATTCATCCTCCTCCCCTGGGATGGCATAGAAGAGACTTTAAAACCAAATGAGCCAAGA
CTCCAAGCTCTGACCACACCTCCCACCCCACCAGTCTTCTCTATGCACCCCCTCTATCTGGAGCCCCCAG
CCAGGTCCTGGACCCAGGTAGCTACATGGCAGAGCATTTAATGTGTGCCTGGCAGCCATGGGCACCATTC
TCCACACAGAAGGCAGGGGACAGGTGCACAAGGCGCTGAGACCCCAGCAGGGCTAACTGTCCTTGTCTCA
GGAGCCCTACCTGGCCAGTCTTGGGCCAGGCCTTGGGGACTGGGAGTAGGGGCTGAGCCCCGTCTGTACA
GTCTCTGGCCCCATGGGCACCAGGTGCCAGCTCCTCGCACCCAGTACTCCCATTGCTAGGGCTGCTGGAA
CCTGCAGGGTGGCAGAGCTGGGCAGGACTCACCCTATAACCATGTCCACTGTGGTGCTGCTGCTGCAGAG
AAGTGTTTCCAATGCTGCGACCCGGGTGTGTAGGACGGGGAGGTCACGATGGCGCGACGTCTGCAGAAAT
TTCATGAGGAGGTATCAGTCTAGAGTTACCCAGGGCCTCGTGGCCGGAGAAACTGCCCAGCAGATCTGTG
AGGACCTCAGGTTGTGTATACCTTCTACAGGTGAGTGCAGAGGTGACAGCAGGGATACCTCCTGAGGGTT
GGAGACAGCTTCCCCCAGGATATATCAAAGCTGCCTCCTTACTCCCCCATCTCCCAGCTTGGGAAAGTGT
GGAGAATTGAGCAGATGGACTTTAGCTAGAAATGTTTGAGAAATACTGATTAGAGCTTGGGCTTCAGACA
CAGGTGGTCGTGGAGTAAAATCTGGTCTCCATCTCTCCCTGGCTGTGTGACCTTAAGCAAATAACTTGAC
CTCTCTGAGCTTCAGTTTCTTCATCTGTGAAGGGGAGATAGCAATCCTGATTTTTGAGATTGGAATGAGA
ATTGAAGGAGGTCACCGTGTGTGTGGACCTGACCCTGGGGAAATGTCCTCAGACTGAGGCTATTCAAGGT
CATCAGACCCTCAGTCAAACTCCAATCCCAGCCCAGCACAGGCCCCTGGGGTCGGGAGCTGGGGCCATAT
CCTCCCCCACAATCCTGGGCCCTGAGATCTGGGCTAGGGAACCCTTCAGGCAGGGGAGCATGAGGCCTTT
CCCTCCATGGCTGCCCAGGCTGTGCCTGGAGAGAACAGATCTCGGCTGTAGGAAATGGGGCCAGAAAGGG
GCCTCGGTGATTGGCTCTGGCAGCTCAGCTGGCACTTGCCAATGCTCTGGGATTTTATGCTGGCAGATCG
GGGGTCCCCACCATTTCCTGTCATTGGAGCTTGTGGCTTTTCTATTCAAGGCCCCACAACCTGCTCAGGC
TGCCGACTGGCTTCCAGGATGTGCCTCTGGGTGTGTTCAGTAGGGTCAGGTGGCTCTGGGACCTTAAGCA
AGTAACATTCTGAGTGCCTGCTTCTCCTTGAGGACCCACCACATCTGCCCACAGCTGGCTGTTCTCTCCT
CTCCAGGTCCCCTCTGAGCCCTCTCACCTTGTCCTGTGGAAGAAGCACAGGCTCCTGTCCTCAGATCCCG
GGAACCTCAGCAACCTCTGCCGGCTCCTCGCTTCCTCGATCCAGAATCCACTCTCCAGTCTCCCTCCCCT
GACTCCCTCTGCTGTCCTCCCCTCTCACGAGAATAAAGTGTCAAGCAAGATTTTAGCCGCAGCTGCTTCT
TCTTTGGTGGATTTGAGGGGTGGGTGTCAGTGGCATGCTGGGGTGAGCTGTGTAGTCCTTCAATAAATGT
CTGTCGTGTGTCCCA
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| Protein Name |
GNLY_HUMAN |
| Length |
145 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-AUG-1991 |
| Definition |
RecName: Full=Granulysin; AltName: Full=Lymphokine LAG-2; AltName: Full=Protein NKG5; AltName: Full=T-cell activation protein 519; Flags: Precursor |
| Primary Accession |
P22749 |
| Accession Version |
P22749.3 |
| Other SeqIDs |
sp|P22749.3|GNLY_HUMAN,gi|116242500 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Oct 17, 2006 this sequence version replaced gi:74739115, gi:1709298.; [FUNCTION] Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.; [INTERACTION] P22749; Q07817: BCL2L1; NbExp=3; IntAct=EBI-17844792, EBI-78035; P22749; Q96Q80: DERL3; NbExp=3; IntAct=EBI-17844792, EBI-12831318.; [SUBCELLULAR LOCATION] Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P22749-1; Sequence=Displayed; Name=Short; IsoId=P22749-2; Sequence=VSP_006016.; [TISSUE SPECIFICITY] Expressed in natural killer and T-cells.; [INDUCTION] By T-cell growth factor and IL2/interleukin-2.; [PTM] A 9 kDa form is produced by proteolytic processing of a 15 kDa protein. {ECO:0000269|PubMed:10449094}. |
| Source Db |
UniProtKB: locus GNLY_HUMAN, accession P22749;; class: standard.; extra accessions:P09325,Q6GU08; created: Aug 1, 1991.; sequence updated: Oct 17, 2006.; annotation updated: Oct 12, 2022.; xrefs: X05044.1, CAA28715.1, X54101.1, CAA38035.1, M85276.1, AAA59935.1, CR541859.1, CAG46657.1, BC023576.2, AAH23576.1, A27562, I54504, NP_001289687.1, NP_006424.2, NP_036615.2, 1L9L_A; xrefs (non-sequence databases): CCDS:CCDS1984.1, CCDS:CCDS46354.1, PDBsum:1L9L, AlphaFoldDB:P22749, SMR:P22749, BioGRID:115829, IntAct:P22749, STRING:9606.ENSP00000263863, DrugBank:DB03434, TCDB:1.C.35.3.2, iPTMnet:P22749, PhosphoSitePlus:P22749, BioMuta:GNLY, DMDM:116242500, MassIVE:P22749, PaxDb:P22749, PeptideAtlas:P22749, PRIDE:P22749, ProteomicsDB:54035, ProteomicsDB:54036, Antibodypedia:31957, DNASU:10578, Ensembl:ENST00000263863.9, Ensembl:ENSP00000263863.5, Ensembl:ENSG00000115523.17, Ensembl:ENST00000409696.7, Ensembl:ENSP00000387116.3, GeneID:10578, KEGG:hsa:10578, MANE-Select:ENST00000263863.9, UCSC:uc002sql.5, CTD:10578, DisGeNET:10578, GeneCards:GNLY, HGNC:4414, HPA:ENSG00000115523, MIM:188855, neXtProt:NX_P22749, OpenTargets:ENSG00000115523, PharmGKB:PA28793, VEuPathDB:HostDB:ENSG00000115523, eggNOG:ENOG502ST3Z, GeneTree:ENSGT00390000002975, InParanoid:P22749, OMA:GFDCKIC, OrthoDB:1413739at2759, PhylomeDB:P22749, TreeFam:TF342210, PathwayCommons:P22749, Reactome:R-HSA-6803157, SignaLink:P22749, BioGRID-ORCS:10578, ChiTaRS:GNLY, EvolutionaryTrace:P22749, GeneWiki:GNLY, GenomeRNAi:10578, Pharos:P22749, PRO:PR:P22749, Proteomes:UP000005640, RNAct:P22749, Bgee:ENSG00000115523, ExpressionAtlas:P22749, Genevisible:P22749, GO:0005576, GO:0005615, GO:0097013, GO:0061844, GO:0006968, GO:0042742, GO:0050832, GO:0031640, InterPro:IPR038847, InterPro:IPR011001, InterPro:IPR008139, PANTHER:PTHR15541, SMART:SM00741, SUPFAM:SSF47862, PROSITE:PS50015 |
| Sequence |
matwallllaamllgnpglvfsrlspeyydlarahlrdeekscpclaqegpqgdlltktqelgrdyrtcltivqklkkmvdkptqrsvsnaatrvcrtgrsrwrdvcrnfmrryqsrvtqglvagetaqqicedlrlcipstgpl |
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